International Journal of General Medicine最新文献

{"title":"Influence of Prone Position on the Survival of COVID-19 Patients Undergoing Invasive Mechanical Ventilation: A Propensity Score Matching Study.","authors":"Yuwei Zheng, Chaochao Chen, Xiaojie Bi, Xiaowei Li, Jing Wang, Yufen Zheng, Yuan Yuan, Yongpo Jiang, Bo Shen, Yinghe Xu","doi":"10.2147/IJGM.S543206","DOIUrl":"10.2147/IJGM.S543206","url":null,"abstract":"<p><strong>Purpose: </strong>The role of prone position (PP) in critically ill patients diagnosed with coronavirus disease 2019 (COVID-19) undergoing invasive mechanical ventilation remains unclear. This study aimed to evaluate the potential prognostic benefits of PP.</p><p><strong>Patients and methods: </strong>This retrospective study included data from 289 critically ill patients with COVID-19 who underwent invasive mechanical ventilation in a multicenter setting. Propensity score matching was used to match 156 patients (78 PP-treated, 78 non-PP-treated) after adjusting for age, sex, underlying disease, and Sequential Organ Failure Assessment score. Between-group comparisons of clinical data, laboratory results, and prognosis were performed. Kaplan-Meier (K-M) survival curve and univariate and multivariate Cox regression analyses were used to explore the relationship between PP and prognosis.</p><p><strong>Results: </strong>Prone positioning improved oxygenation (oxygenation index in the PP group increased consistently, with the greatest improvement observed on days 12-13 compared with the non-PP group [48 vs 32 mmHg; P < 0.001]) and increased hospital survival (80.8% vs 65.4%; P = 0.047). K-M survival curve analysis revealed that patients treated with PP had a more favorable prognosis (P = 0.025). Multivariate Cox regression revealed that PP was linked to lower risk of death (HR 0.389 [95% CI 0.173-0.878]), while age (HR 1.053 [95% CI 1.012-1.096]), Acute Physiology and Chronic Health Evaluation II score (HR 1.055 [95% CI 1.006-1.107]), and troponin T levels (HR 2.028 [95% CI 1.222-3.367]) were linked to higher risk of death in the overall survival of patients with COVID-19.</p><p><strong>Conclusion: </strong>PP improved oxygenation and increased the survival rate of critically ill patients with COVID-19 undergoing invasive mechanical ventilation. Adopting PP as much as possible during nursing care may enhance patient survival.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5367-5377"},"PeriodicalIF":2.0,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality Analysis of Unplanned Readmissions Using Fishbone Diagram and Pareto Chart in a Chinese Tertiary Hospital.","authors":"Wen Hu, Li Ma, Shan Xiong, Sifeng Li, Xiaocheng Wang, Min Liu, Zhenni Chen","doi":"10.2147/IJGM.S540011","DOIUrl":"10.2147/IJGM.S540011","url":null,"abstract":"<p><strong>Purpose: </strong>Existing research on unplanned readmissions has primarily focused on department- or disease-specific analyses, yet it lacks a systematic hospital management perspective. This study employs quality improvement tools to analyze causes of unplanned readmissions, identify key drivers, and lay the groundwork for interventions that reduce readmission rates, alleviate patient burdens, and optimize healthcare resource utilization.</p><p><strong>Patients and methods: </strong>This retrospective study included 341 patients who were readmitted within 31 days due to the same or related diseases. These patients were identified at a public tertiary Grade A general hospital in Chengdu between January 1, 2023, and December 31, 2024. Fishbone diagram was used to analyze the root causes of unplanned readmissions, while Pareto chart was employed to determine the distribution of the primary causes. Data were sourced from the hospital's information management system.</p><p><strong>Results: </strong>The overall unplanned readmission rate was 0.38%. In surgical patients, unplanned readmissions were predominantly attributed to surgical complications (75.79%), which primarily included surgical site infections, respiratory infections, postoperative hemorrhage or hematoma, thromboembolic events, and impaired wound healing. Preventing the above-mentioned surgical complications is a key measure to reduce readmissions among surgical patients. For non-surgical patients, disease exacerbation constituted the primary cause of unplanned readmissions (72.19%), with pancreatitis, chronic obstructive pulmonary disease, cardiac arrhythmia, and fungal pneumonia identified as high-risk diseases leading to readmissions. Strengthening the management of these high-risk diseases is crucial for preventing readmissions among non-surgical patients.</p><p><strong>Conclusion: </strong>Employing integrated fishbone diagram and Pareto chart analyses, this study systematically deciphered the root causes and dominant contributors to unplanned readmissions. These findings enabled the formulation of targeted evidence-based management strategies. This study provides novel insights and methodologies for hospital management practices, serving as a valuable reference for other healthcare institutions seeking to reduce unplanned readmission rates and enhance operational efficiency.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5295-5302"},"PeriodicalIF":2.0,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pan-Immune-Inflammation Value (PIV) and Prognostic Nutritional Index (PNI) are Associated with Distant Metastasis in Colorectal Cancer with <i>KRAS</i> Mutation but Not in Those with <i>KRAS</i> Wild-Type.","authors":"Yunlin Li, Yuwen Zeng","doi":"10.2147/IJGM.S541575","DOIUrl":"10.2147/IJGM.S541575","url":null,"abstract":"<p><strong>Background: </strong>Pan-immune-inflammation value (PIV) and prognostic nutritional index (PNI) have values in the prognosis assessment of tumors. However, their relationship with the distant metastasis risk of colorectal cancer (CRC) remains unclear. The aim of our study was to explore the relationship between PIV and PNI and the risk of distant metastasis in CRC patients with and without <i>KRAS</i> mutation.</p><p><strong>Methods: </strong>The clinical data (age, gender, body mass index (BMI), cigarette smoking, alcoholism, and diabetes mellitus, family history of tumor, tumor stage, and <i>KRAS/NRAS</i> mutation status) of 2408 CRC patients were retrospectively collected and analyzed. The optimal thresholds of PIV and PNI were evaluated by receiver operating characteristic (ROC) curve analysis. Logistic regression analysis was used to reveal the relationship of PIV and PNI and distant metastasis in CRC with and without <i>KRAS</i> mutation, respectively.</p><p><strong>Results: </strong>The average levels of PIV and PNI was 327.62 (183.19, 590.36) and 46.70 (43.10, 50.90). There were 825 (34.3%) patients with distant metastasis and 1583 (65.7%) without. The optimal threshold of PIV and PNI was 339.50 and 45.53 by ROC analysis. Logistic regression analysis showed that stage T3-T4 (odds ratio (OR): 2.967, 95% confidence interval (CI): 1.804-4.880, <i>p</i><0.001), and stage N2-N3 (OR: 5.109, 95% CI: 3.886-6.717, <i>p</i><0.001) were associated with distant metastasis in CRC with <i>KRAS</i> wild-type; while stage T3-T4 (OR: 5.963, 95% CI: 2.897-12.273, <i>p</i><0.001), and stage N2-N3 (OR: 7.094, 95% CI: 5.070-9.926, <i>p</i><0.001), high PIV (OR: 2.867, 95% CI: 2.119-3.879, <i>p</i><0.001), and low PNI (OR: 1.620, 95% CI: 1.184-2.215, <i>p</i>=0.003) were associated with distant metastasis in CRC with <i>KRAS</i> mutation.</p><p><strong>Conclusion: </strong>Stages T3-T4 and N2-N3 were associated with distant metastasis in CRC with and without <i>KRAS</i> mutation. High PIV and low PNI were associated with distant metastasis in CRC patients with <i>KRAS</i> mutation, but not in patients without <i>KRAS</i> mutation.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5315-5327"},"PeriodicalIF":2.0,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prognostic Significance of Visceral Adiposity Indices in Conjunction with Plasma Trace Elements in Newly Diagnosed Crohn's Disease.","authors":"Jiakai Luo, Gengfeng Li, Wen Hu, Keren Shen, Xiaoxu Huang, Xiaoying Wang, Dingting Xu, Yan Ma, Minfang Lv, Shuyan Li, Yan Chen, Qiao Yu","doi":"10.2147/IJGM.S523034","DOIUrl":"10.2147/IJGM.S523034","url":null,"abstract":"<p><strong>Purpose: </strong>Visceral adipose tissue (VAT) is integral to the pathology of Crohn's disease (CD). While trace element imbalances affect both adipose tissue function and CD progression, their interplay remains poorly characterized. This study aimed to examine whether trace element status affects CD outcomes and whether this relationship is moderated by visceral adiposity.</p><p><strong>Patients and methods: </strong>The data were collected retrospectively based on a prospective cohort of 300 patients newly diagnosed with CD from July 2019 to June 2022. Baseline plasma trace element levels were assessed, and VAT was measured via computed tomography (CT) scans at the time of diagnosis. Logistic regression analyses were performed.</p><p><strong>Results: </strong>Lower zinc and magnesium levels predicted clinical outcomes including intestinal complications and surgery (OR = 0.51, <i>P</i> = 0.002; OR = 0.52, <i>P</i> = 0.001), and poorer treatment response (OR = 0.39, <i>P</i> < 0.001; OR = 0.57, <i>P</i> = 0.004). Elevated copper levels were associated with clinical outcomes (OR = 1.68, <i>P</i> = 0.012). Notably, stratified analysis revealed that magnesium's protective effect was significant exclusively in patients with visceral-to-subcutaneous adipose tissue ratio (VAT/SAT) ≥ 1, whereas the effect of copper was significant solely in the VAT/SAT < 1 group concerning clinical outcomes.</p><p><strong>Conclusion: </strong>Dysregulated trace element homeostasis at baseline independently predicts adverse clinical outcomes in CD. The intricate relationship between trace elements and VAT could influence disease progression, suggesting potential targets for personalized treatment.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5283-5294"},"PeriodicalIF":2.0,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of Macular Microvascular Changes in Patients with Symptomatic Lacunar Cerebral Infarction Using Viaoptical Coherence Tomography Angiography (OCTA).","authors":"Meishuang Li, Huiyu Xi, Rongrong Guan, Yalu Liu, Lina Guan, Dandan Zong, Nuan Wang, Haiyang Liu","doi":"10.2147/IJGM.S534255","DOIUrl":"10.2147/IJGM.S534255","url":null,"abstract":"<p><strong>Objective: </strong>To investigate retinal and choroidal vascular density (VD) changes in the macular region of patients with symptomatic lacunar cerebral infarction (LI) and assess whether these changes can predict symptomatic LI.</p><p><strong>Methods: </strong>This cross-sectional study included 49 symptomatic LI patients (49 eyes) and 51 healthy controls (51 eyes). OCTA was employed to measure retinal VD in the superficial capillary plexus (SCP) and deep capillary plexus (DCP), as well as the ganglion cell complex (GCC) thickness. Enhanced depth imaging optical coherence tomography (EDI-OCT) was utilized to calculate the choroidal vascular index (CVI).</p><p><strong>Results: </strong>Significant differences were observed in macular VD of the SCP and DCP, GCC thickness, and CVI, systolic pressure, diastolic pressure, between the symptomatic LI and control groups (p < 0.05). Binary logistic regression analysis indicated that lower VD in the SCP and DCP, along with reduced GCC thickness, elevated diastolic blood pressure, were significantly associated with symptomatic LI (OR < 1, p < 0.05). Receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC) was higher for SCP total vessel density and GCC thickness, while the whole VD of SCP+GCC thickness had the highest area under the curve (AUC =0.880, sensitivity =87.80% and specificity =74.50%).</p><p><strong>Conclusion: </strong>In patients with symptomatic LI, reductions in VD within the SCP and DCP, along with decreased GCC thickness and CVI, were observed. These diminished vascular densities in the SCP and reduced GCC thickness may serve as predictive markers for symptomatic LI.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5243-5256"},"PeriodicalIF":2.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenesis of HIV-Associated Metabolic Syndrome and Clinical Management Recommendations.","authors":"Lichao Ge, Xianjiang Tian, Chunfeng Sun, Piao Hu, Mei Yu","doi":"10.2147/IJGM.S528870","DOIUrl":"10.2147/IJGM.S528870","url":null,"abstract":"<p><p>The phenomenon of metabolic syndrome in patients with HIV infection has attracted increasing attention. HIV infection increases the risk of metabolic complications, including cardiovascular diseases and diabetes. Meanwhile, the potential metabolic side effects of antiretroviral therapy in HIV patients have emerged as a new clinical challenge. This study delineates the potential mechanisms underlying HIV-associated metabolic syndrome, encompassing inflammation and immune activation, glucose and lipid metabolism disorders, mitochondrial and vascular endothelial abnormalities, gut microbiota dysbiosis, epigenetic alterations, and the application of certain antiretroviral drugs. These mechanisms interact and exacerbate each other, with inflammation and immune activation playing a pivotal role. This study also discusses the potential associations between HIV infection and various metabolic diseases, and consolidates clinical management recommendations for HIV-associated metabolic syndrome, including diet, exercise, and lipid, glucose, and blood pressure management.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5213-5232"},"PeriodicalIF":2.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angiotensin-Converting Enzyme Inhibitors Mitigate Development of Chronic Persistent Cardiac Dysfunction Following Fulminant Myocarditis: A Multicenter Retrospective Study in China.","authors":"Hong Yang, Wuyun Qidamugai, Luyun Wang, FuYang Liu, Yi He, Zheng Xu, Li Zhang, Fan Li, Hong Wang, Jiangang Jiang","doi":"10.2147/IJGM.S543878","DOIUrl":"10.2147/IJGM.S543878","url":null,"abstract":"<p><strong>Background: </strong>Although temporary mechanical circulatory supports (tMCS) combined with immunoregulatory therapy (IT) can reduce the mortality of patients with fulminant myocarditis (FM), a considerable proportion still progress to chronic persistent cardiac dysfunction. It is unclear if angiotensin-converting enzyme (ACE) inhibitors can further prevent such dysfunction under tMCS combined with IT.</p><p><strong>Methods: </strong>This multicenter, retrospective, observational study included 124 FM patients with a left ventricular ejection fraction (LVEF) ≤ 40%. Among them, 90 (72.58%) received ACE inhibitors and 34 (27.42%) did not. Patients had echocardiography during follow-up. Logistic regression analysis, subgroup analysis, and restricted cubic spline modeling were used to identify clinical variables associated with the primary outcome.</p><p><strong>Results: </strong>The primary outcome was defined as an LVEF < 55% at the last follow-up. The median follow-up was 12 (6, 18) months. 46 patients (37.1%) had an LVEF < 55% at the last follow-up. Among them, 25 (27.78%) received ACE inhibitors and 21 (61.76%) did not. In the non-ACE inhibitors group, LVEF declined from baseline over 24 months. Among the 49 patients (39.52%) with a left ventricular end-diastolic dimension (LVEDD) ≥ 5cm at admission, 29 (59.18%) had an LVEF < 55% at the last follow-up. 15 patients (51.72%) took ACE inhibitors and 14 (48.28%) did not. Multivariate logistic regression analysis revealed that ACE inhibitors (HR = 0.19, 95% CI: 0.04-0.96, P = 0.045) and LVEDD (HR = 9.18, 95% CI: 2.73-30.83, P < 0.001) were independently associated with an LVEF < 55% at the last follow-up, and the risk increased linearly with LVEDD (P for nonlinear > 0.05).</p><p><strong>Conclusion: </strong>ACE inhibitors may improve left ventricular (LV) function and prevent chronic persistent cardiac dysfunction in FM patients. Although they can partially reverse LV remodeling, increased LVEDD during long-term follow-up may reduce their therapeutic benefits.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5267-5281"},"PeriodicalIF":2.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Static Balance in Prediabetic Subjects: Correlation Study Involving Glucose Indicators, Insulin Resistance and Postural Stability Indices.","authors":"Zhishan Wang, Yihang Chen, Weijun Yang, Yuanya Xie, Miaoyun Li, Jingran Liang, Xingyu Li, LingJing Gao, Dehong Pan, Xiaoling Wang, Shujiao Chen","doi":"10.2147/IJGM.S547267","DOIUrl":"10.2147/IJGM.S547267","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationship between different glycemic parameters and static balance function in prediabetic patients.</p><p><strong>Patients and methods: </strong>A total of 92 prediabetic patients who attended The Third Affiliated Hospital of Fujian University of Traditional Chinese Medicine from October 2023 to February 2024 were enrolled in this observational study. All patients underwent assessments of glucose parameters, insulin resistance, and static balance function parameters. Spearman rank correlation test was used to analyze the correlations between these indices.</p><p><strong>Results: </strong>Among the 92 participants, age, gender, height, weight, BMI, FIns, 2hPG, HOMA-IR, and HbA1c were correlated with static balance function. Specifically, age was negatively correlated with visual and vestibular function; height and weight were negatively correlated with proprioception; and BMI was negatively correlated with proprioception, vision, and vestibular function. 2hPG and HbA1c were negatively correlated with vestibular function and proprioception, respectively, while HOMA-IR and FIns were negatively correlated with vestibular function and vision. For patients with poorly controlled 2hPG or HbA1c, emphasis is recommended on coronal plane postural control training; for those with poorly controlled HOMA-IR or FIns, priority should be given to sagittal plane postural control training.</p><p><strong>Conclusion: </strong>Through multi-indicator correlation analysis, this study preliminarily identifies the potential mechanisms underlying the association between abnormal glucose metabolism and static balance dysfunction in prediabetic patients. These findings provide a reference for further exploration of clinical research on combined \"glycemic control-balance training\" interventions.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5233-5242"},"PeriodicalIF":2.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Triglyceride-Glucose Index and Gout in Young Adults in China.","authors":"Cong Huang, Xiaodong Gu, Sudong Liu, Honghui Luo, Yiqun Luo, Yu Zhang","doi":"10.2147/IJGM.S550057","DOIUrl":"10.2147/IJGM.S550057","url":null,"abstract":"<p><strong>Objective: </strong>Gout is a common inflammatory arthritis with a rising prevalence among young adults in China, imposing a substantial burden on patients and society. This study aims to examine the association between the triglyceride-glucose (TyG) index and the presence of gout among young Chinese adults.</p><p><strong>Methods: </strong>We conducted a retrospective, age- and sex-matched (1:4) case-control study at Meizhou People's Hospital (2019-2023). Continuous variables were summarized as mean ± SD or median (IQR) and compared with Student's <i>t</i> test or the Mann-Whitney <i>U</i>-test. The association between the TyG index and prevalent gout was examined using multivariable logistic regression; multicollinearity was assessed. The diagnostic performance of the TyG index was evaluated by receiver operating characteristic, and Spearman correlation assessed TyG vs uric acid (UA), white blood cell count (WBC), systemic immune-inflammation index (SII), and high-density lipoprotein cholesterol (HDL-C).</p><p><strong>Results: </strong>The study included 447 gout patients and 1788 controls (average age 34.5 ± 6.9 years). Median TyG was higher in the gout group than in controls (4.86 [0.44] vs 4.63 [0.40]; <i>P</i> < 0.001). In multivariable logistic regression, higher TyG was independently associated with gout (adjusted OR = 2.454; 95% CI: 1.496-4.026, <i>P</i> < 0.001). TyG yielded an AUC of 0.709 (95% CI: 0.683-0.736), with an optimal cutoff of 4.735 (sensitivity 0.669; specificity 0.638). TyG correlated positively with UA (<i>r</i> = 0.3393), WBC (<i>r</i> = 0.3250), and SII (<i>r</i> = 0.2069) and inversely with HDL-C (<i>r</i> = -0.4913); all <i>P</i> < 0.001.</p><p><strong>Conclusion: </strong>In this cross-sectional study of young Chinese adults, higher TyG was independently associated with the presence of gout and showed acceptable discrimination. As a routinely available metric, TyG may aid risk stratification and case-finding; prospective studies are needed to define actionable thresholds and clarify temporality.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5257-5266"},"PeriodicalIF":2.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamics of Conventional Metabolic Indices in Relation to Endometriosis Severity: A Retrospective Analysis.","authors":"Xiaolin Zhong, Weihong Lu, Qi Zhang, Jie Dong, Hongyang Xiao, Ruiqin Tu","doi":"10.2147/IJGM.S537848","DOIUrl":"10.2147/IJGM.S537848","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate the association between the dynamics of routine metabolic markers and endometriosis severity.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on patients diagnosed with endometriosis at Zhongshan Hospital, Xiamen, affiliated with Fudan University. The collected data encompassed demographic details and biochemical indicators related to lipid, hepatobiliary, renal metabolism, and electrolyte balance. Independent influencing factors were screened by univariate logistic regression and statistically significant variables were included in the model for adjustment. Restricted cubic spline (RCS) models were also plotted to analyze the nonlinear relationship between factors and endometriosis severity. The receiver operating characteristic (ROC) curve was used to validate the discriminative ability of independent influencing factors.</p><p><strong>Results: </strong>Ninety-four patients were enrolled in the study, including 32 at stage IV as classified by the American Society for Reproductive Medicine (ASRM) staging. Univariate analysis identified fasting blood glucose (FBG), total protein, direct bilirubin, total bilirubin (TBil) and glutamic-pyruvic transaminase (ALT) as significant metabolic indicators. Additionally, carbohydrate antigen 125 (CA125) and human epididymal protein 4 (HE4) emerged as significant covariates. The RCS analysis revealed a nonlinear association between most metabolic indicators and outcome measures. ROC curve analysis showed that the area under the curve (AUC) of the alanine transaminase (ALT) was above 0.6.</p><p><strong>Conclusion: </strong>ALT had a negative correlation with the severity of endometriosis and was an independent influencing factor with statistical significance. This finding could offer clinicians non-invasive biomarkers for early detection and precise monitoring of disease progression.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5183-5193"},"PeriodicalIF":2.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}