Pathogenesis of HIV-Associated Metabolic Syndrome and Clinical Management Recommendations.

IF 2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
International Journal of General Medicine Pub Date : 2025-09-09 eCollection Date: 2025-01-01 DOI:10.2147/IJGM.S528870
Lichao Ge, Xianjiang Tian, Chunfeng Sun, Piao Hu, Mei Yu
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Abstract

The phenomenon of metabolic syndrome in patients with HIV infection has attracted increasing attention. HIV infection increases the risk of metabolic complications, including cardiovascular diseases and diabetes. Meanwhile, the potential metabolic side effects of antiretroviral therapy in HIV patients have emerged as a new clinical challenge. This study delineates the potential mechanisms underlying HIV-associated metabolic syndrome, encompassing inflammation and immune activation, glucose and lipid metabolism disorders, mitochondrial and vascular endothelial abnormalities, gut microbiota dysbiosis, epigenetic alterations, and the application of certain antiretroviral drugs. These mechanisms interact and exacerbate each other, with inflammation and immune activation playing a pivotal role. This study also discusses the potential associations between HIV infection and various metabolic diseases, and consolidates clinical management recommendations for HIV-associated metabolic syndrome, including diet, exercise, and lipid, glucose, and blood pressure management.

Abstract Image

hiv相关代谢综合征的发病机制和临床管理建议。
HIV感染者的代谢综合征现象越来越受到人们的关注。艾滋病毒感染增加了代谢并发症的风险,包括心血管疾病和糖尿病。同时,抗逆转录病毒治疗对HIV患者潜在的代谢副作用已经成为一个新的临床挑战。这项研究描述了hiv相关代谢综合征的潜在机制,包括炎症和免疫激活、葡萄糖和脂质代谢紊乱、线粒体和血管内皮异常、肠道微生物群失调、表观遗传改变和某些抗逆转录病毒药物的应用。这些机制相互作用并相互加剧,炎症和免疫激活起着关键作用。本研究还讨论了HIV感染与各种代谢性疾病之间的潜在关联,并整合了针对HIV相关代谢综合征的临床管理建议,包括饮食、运动、脂质、葡萄糖和血压管理。
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来源期刊
International Journal of General Medicine
International Journal of General Medicine Medicine-General Medicine
自引率
0.00%
发文量
1113
审稿时长
16 weeks
期刊介绍: The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.
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