{"title":"应用光学相干断层扫描血管造影(OCTA)研究症状性腔隙性脑梗死患者黄斑微血管变化。","authors":"Meishuang Li, Huiyu Xi, Rongrong Guan, Yalu Liu, Lina Guan, Dandan Zong, Nuan Wang, Haiyang Liu","doi":"10.2147/IJGM.S534255","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigate retinal and choroidal vascular density (VD) changes in the macular region of patients with symptomatic lacunar cerebral infarction (LI) and assess whether these changes can predict symptomatic LI.</p><p><strong>Methods: </strong>This cross-sectional study included 49 symptomatic LI patients (49 eyes) and 51 healthy controls (51 eyes). OCTA was employed to measure retinal VD in the superficial capillary plexus (SCP) and deep capillary plexus (DCP), as well as the ganglion cell complex (GCC) thickness. Enhanced depth imaging optical coherence tomography (EDI-OCT) was utilized to calculate the choroidal vascular index (CVI).</p><p><strong>Results: </strong>Significant differences were observed in macular VD of the SCP and DCP, GCC thickness, and CVI, systolic pressure, diastolic pressure, between the symptomatic LI and control groups (p < 0.05). Binary logistic regression analysis indicated that lower VD in the SCP and DCP, along with reduced GCC thickness, elevated diastolic blood pressure, were significantly associated with symptomatic LI (OR < 1, p < 0.05). Receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC) was higher for SCP total vessel density and GCC thickness, while the whole VD of SCP+GCC thickness had the highest area under the curve (AUC =0.880, sensitivity =87.80% and specificity =74.50%).</p><p><strong>Conclusion: </strong>In patients with symptomatic LI, reductions in VD within the SCP and DCP, along with decreased GCC thickness and CVI, were observed. These diminished vascular densities in the SCP and reduced GCC thickness may serve as predictive markers for symptomatic LI.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"5243-5256"},"PeriodicalIF":2.0000,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433219/pdf/","citationCount":"0","resultStr":"{\"title\":\"Study of Macular Microvascular Changes in Patients with Symptomatic Lacunar Cerebral Infarction Using Viaoptical Coherence Tomography Angiography (OCTA).\",\"authors\":\"Meishuang Li, Huiyu Xi, Rongrong Guan, Yalu Liu, Lina Guan, Dandan Zong, Nuan Wang, Haiyang Liu\",\"doi\":\"10.2147/IJGM.S534255\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To investigate retinal and choroidal vascular density (VD) changes in the macular region of patients with symptomatic lacunar cerebral infarction (LI) and assess whether these changes can predict symptomatic LI.</p><p><strong>Methods: </strong>This cross-sectional study included 49 symptomatic LI patients (49 eyes) and 51 healthy controls (51 eyes). OCTA was employed to measure retinal VD in the superficial capillary plexus (SCP) and deep capillary plexus (DCP), as well as the ganglion cell complex (GCC) thickness. Enhanced depth imaging optical coherence tomography (EDI-OCT) was utilized to calculate the choroidal vascular index (CVI).</p><p><strong>Results: </strong>Significant differences were observed in macular VD of the SCP and DCP, GCC thickness, and CVI, systolic pressure, diastolic pressure, between the symptomatic LI and control groups (p < 0.05). Binary logistic regression analysis indicated that lower VD in the SCP and DCP, along with reduced GCC thickness, elevated diastolic blood pressure, were significantly associated with symptomatic LI (OR < 1, p < 0.05). Receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC) was higher for SCP total vessel density and GCC thickness, while the whole VD of SCP+GCC thickness had the highest area under the curve (AUC =0.880, sensitivity =87.80% and specificity =74.50%).</p><p><strong>Conclusion: </strong>In patients with symptomatic LI, reductions in VD within the SCP and DCP, along with decreased GCC thickness and CVI, were observed. These diminished vascular densities in the SCP and reduced GCC thickness may serve as predictive markers for symptomatic LI.</p>\",\"PeriodicalId\":14131,\"journal\":{\"name\":\"International Journal of General Medicine\",\"volume\":\"18 \",\"pages\":\"5243-5256\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-09-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433219/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of General Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/IJGM.S534255\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of General Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/IJGM.S534255","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Study of Macular Microvascular Changes in Patients with Symptomatic Lacunar Cerebral Infarction Using Viaoptical Coherence Tomography Angiography (OCTA).
Objective: To investigate retinal and choroidal vascular density (VD) changes in the macular region of patients with symptomatic lacunar cerebral infarction (LI) and assess whether these changes can predict symptomatic LI.
Methods: This cross-sectional study included 49 symptomatic LI patients (49 eyes) and 51 healthy controls (51 eyes). OCTA was employed to measure retinal VD in the superficial capillary plexus (SCP) and deep capillary plexus (DCP), as well as the ganglion cell complex (GCC) thickness. Enhanced depth imaging optical coherence tomography (EDI-OCT) was utilized to calculate the choroidal vascular index (CVI).
Results: Significant differences were observed in macular VD of the SCP and DCP, GCC thickness, and CVI, systolic pressure, diastolic pressure, between the symptomatic LI and control groups (p < 0.05). Binary logistic regression analysis indicated that lower VD in the SCP and DCP, along with reduced GCC thickness, elevated diastolic blood pressure, were significantly associated with symptomatic LI (OR < 1, p < 0.05). Receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC) was higher for SCP total vessel density and GCC thickness, while the whole VD of SCP+GCC thickness had the highest area under the curve (AUC =0.880, sensitivity =87.80% and specificity =74.50%).
Conclusion: In patients with symptomatic LI, reductions in VD within the SCP and DCP, along with decreased GCC thickness and CVI, were observed. These diminished vascular densities in the SCP and reduced GCC thickness may serve as predictive markers for symptomatic LI.
期刊介绍:
The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas.
A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal.
As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.