Clinicopathological Analysis of Patients with Isolated Hematuria and/or Mild Proteinuria.

Abstract

Objective: This investigation aimed to explore the clinicopathological features of patients with isolated hematuria and/or mild proteinuria in kidney disease.

Materials and methods: We conducted a retrospective review of the clinical and pathological information of patients initially diagnosed with chronic nephritis syndrome in the Nephrology Department of Yuebei People's Hospital.

Results: In total, 227 participants were recruited for the study, including 79 patients (34.8%) in the group with isolated hematuria and/or mild proteinuria and 148 patients (65.2%) in the group with medium-large amounts of proteinuria. There were 29 cases (36.7%) of IgA nephropathy, seven cases (8.9%) of focal segmental glomerulosclerosis, six cases (7.6%) of membranous nephropathy, and six cases (7.9%) of acute renal tubular injury in the group with isolated hematuria and/or mild proteinuria. The common pathological types in the medium-large proteinuria group were membranous nephropathy in 68 cases (45.9%), minimal change nephropathy in 25 cases (16.9%), and IgA nephropathy in 20 cases (13.5%).

Conclusion: IgA nephropathy is the main pathological type in the group with isolated hematuria and/or mild proteinuria, while membranous nephropathy is the common pathological type in the group with moderate to severe proteinuria. There was a significantly stronger correlation between the level of hematuria/proteinuria and both BMI and MAP.