International Journal of General Medicine最新文献

{"title":"Using Radial Shock Wave Therapy to Control Cerebral Palsy-Related Dysfunctions: A Randomized Controlled Trial.","authors":"Hisham M Hussein, Ahmed M Gabr, Monira I Aldhahi, Amsha Alhumaidi Alshammari, Hand Zamel Alshammari, Khulood Khleiwi Altamimi, Abdulaziz Mohammed Alqahtani, Ibrahim M Dewir, Shamekh Mohamed El-Shamy, Ahmed Abdelmoniem Ibrahim","doi":"10.2147/IJGM.S510383","DOIUrl":"10.2147/IJGM.S510383","url":null,"abstract":"<p><strong>Background: </strong>Radial Shock wave Therapy (rSWT) is one of the recent promising modalities that can effectively improve muscle tone, ROM, and enhance functional capacity. It can be used to augment the rehabilitation effectiveness in spastic CP children. So, enhance their engagement in community and participation in social activities and decrease economic burden of rehabilitation.</p><p><strong>Purpose: </strong>To investigate the effect of adding rSWT to standard physical therapy on muscular spasticity, ROM, gross motor function, and planter surface in spastic CP patients.</p><p><strong>Methods: </strong>A total of 70 children (48 girls and 22 boys) with spastic CP were randomly assigned into the control group (n= 35 and average age 8.82±0.91) which received standard physical therapy and the rSWT group (n=35 and average age 9.0±1.81) which received the standard physical therapy plus 1500 rSWT shocks with 2 bar pressure and Hz frequency applied over acupuncture points. Passive ankle ROM, calf muscle tone, gross motor function (D and E categories), plantar surface area (PSA), and peak pressure values at midfoot (PPMF), and hindfoot (PPHF) were assessed at baseline, post-treatment, and three-month follow-up.</p><p><strong>Results: </strong>Between-group comparisons demonstrated post-treatment statistically significant differences in ankle plantar flexion (APF), walking category of the GMFM (GMFM-E), PPHF, and PPMF with medium to high effect size values favoring the rSWTG (p=0.011, <i>d</i>=0.858; p=0.003, <i>d</i>=1.02; p=0.035, <i>d</i>=0.577; p=0.049, <i>d</i>= 0.216, respectively). At follow-up, all outcomes were statistically significantly different (p<0.05).</p><p><strong>Conclusion: </strong>rSWT is an effective addition to the standard physical therapy care for spastic CP children in favor of spasticity, ROM, and function.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1439-1450"},"PeriodicalIF":2.1,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the SOX Regimen on Immune Function and Tumor Markers in Advanced Gastric Cancer.","authors":"Yifen Liu, Jian-Gang Zhao, Guang-Yuan Zhao","doi":"10.2147/IJGM.S509902","DOIUrl":"https://doi.org/10.2147/IJGM.S509902","url":null,"abstract":"<p><strong>Background: </strong>Locally advanced gastric cancer presents significant challenges in treatment, often limiting the effectiveness of surgical interventions. Chemotherapy, especially the SOX regimen (combining oxaliplatin and tegafur/gimeracil/oteracil), has been explored as a potential alternative in the management of advanced gastric cancer. While studies on SOX have been conducted in other regions, its impact on immune function and tumor markers remains inadequately evaluated, particularly in China.</p><p><strong>Objective: </strong>This study aimed to assess the toxicological profile, immune function modulation, and tumor marker reduction of the SOX regimen in patients with advanced gastric cancer.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 100 patients diagnosed with advanced gastric cancer, excluding eight ineligible cases. Based on clinical records, patients were grouped into either the oxaliplatin monotherapy group (reference group) or the SOX regimen group (observation group), with 50 patients in each group. The primary endpoint was clinical effectiveness, while secondary endpoints included immune function, tumor marker levels, and chemotherapy-related toxicity.</p><p><strong>Results: </strong>The SOX regimen demonstrated significantly higher disease control and objective remission rates compared to oxaliplatin monotherapy (P<0.05). In the SOX group, immune function was enhanced, with increased levels of immunoglobulins (IgA, IgG, IgM) and lymphocyte subsets (CD3+, CD4+, NK cells), and a decrease in CD8+ levels (P<0.05). Additionally, tumor markers such as CA125, CEA, MRP14, SDF-1, FSP-1, and CXCR4 showed a significant reduction (P<0.05). The SOX regimen also exhibited a more favorable safety profile, with lower incidences of chemotherapy-related nausea, vomiting, and leukopenia (P<0.05).</p><p><strong>Conclusion: </strong>The SOX regimen is an effective and promising treatment option for advanced gastric cancer, offering significant improvements in clinical outcomes, immune function, and tumor marker reduction, with fewer chemotherapy-related toxicities. This study provides valuable insights into the application of the SOX regimen in Chinese patients with advanced gastric cancer.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1415-1422"},"PeriodicalIF":2.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intramyocardial Hemorrhage in Patients with Acute Myocardial Infarction Without Reperfusion Therapy: A Prospective Study.","authors":"Muzheng Li, Zhijian Wu, Ilyas Tudahun, Kun Zhang","doi":"10.2147/IJGM.S501504","DOIUrl":"https://doi.org/10.2147/IJGM.S501504","url":null,"abstract":"<p><strong>Background and aims: </strong>IMH commonly presents in STEMI patients receiving reperfusion therapy and is considered as an ischemic reperfusion injury. However, it is unclear whether IMH occurs in AMI patients without reperfusion therapy.</p><p><strong>Methods and results: </strong>We prospectively enrolled 40 patients with STEMI and 41 patients with NSTEMI admitted to the CCU of the Second Xiangya Hospital of Central South University from April 2020 to November 2021, all of whom did not receive reperfusion therapy. In the STEMI group, 16 patients were detected with IMH by CMR. However, in the NSTEMI group, only 3 patients were detected. The incidence of IMH was significantly higher in patients with STEMI than NSTEMI (16/40 vs 3/41, P < 0.001). Among patients with STEMI, the incidence of IMH was not significantly different between patients who underwent primary percutaneous coronary intervention and those who did not (16/40 vs 27/65, P = 0.876). Patients in the spontaneous reperfusion group had a higher incidence of IMH than patients in the non-spontaneous reperfusion group (11/23 vs 5/17, P = 0.240). Similarly, in patients with STEMI who did not receive reperfusion therapy, the incidence of MACE was higher in the IMH-present group than in the IMH-absent group (5/16 vs 2/24, P = 0.063).</p><p><strong>Conclusion: </strong>The incidence of IMH is comparable in patients with STEMI with or without reperfusion therapy, but considerably higher than that in NSTEMI patients. Patients with STEMI can present with IMH even when infarct-related vessel flow is not restored.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1393-1401"},"PeriodicalIF":2.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Diagnostic Value of Serum MCP-1 Combined with OPN Detection for Early Renal Injury in Gout Patients.","authors":"Haiying Chang, Jing Lv, Yinglin Zheng, Dongsheng Li, Yi Li","doi":"10.2147/IJGM.S508220","DOIUrl":"https://doi.org/10.2147/IJGM.S508220","url":null,"abstract":"<p><strong>Objective: </strong>To explore the changes in serum Monocyte chemoattractant protein-1 (MCP-1) and Osteopontin (OPN) in gout patients and their diagnostic value for early renal injury.</p><p><strong>Methods: </strong>In this research, 174 gout patients (January 2022-October 2024) were divided into the early renal injury group (50 cases) and non-early renal injury group (124 cases). Additionally, 169 healthy individuals were included as controls. Clinical indicators such as serum creatinine, cystatin C (CysC), and GFR were recorded. MCP-1 and OPN levels were measured using ELISA. Pearson's correlation was used to analyze relationships; Logit regression was applied to identify influencing factors, and ROC curves assessed diagnostic value, with AUC comparisons via Z-test.</p><p><strong>Results: </strong>Serum MCP-1 and OPN levels were significantly higher in the gout group compared to controls (P<0.05) and further elevated in the early renal injury group (P<0.05). MCP-1 and OPN correlated positively with creatinine and CysC and negatively with GFR (P<0.05). Logit regression identified MCP-1 (OR: 2.765, 95% CI: 1.308-5.846) and OPN (OR: 3.019, 95% CI: 1.468-6.210) as independent risk factors (P<0.05). The AUC for diagnosing early renal injury was 0.775 (MCP-1), 0.827 (OPN), and 0.938 (combined), with the combination significantly outperforming either marker alone (Z=3.075, 2.273, P<0.05).</p><p><strong>Conclusion: </strong>The combination of serum MCP-1 and OPN in gout patients has a higher diagnostic value for early renal injury, it is obviously higher than the individual diagnosis of each indicator, and demonstrates significant clinical implications.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1423-1429"},"PeriodicalIF":2.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Fatigue in Inflammatory Bowel Disease: A Narrative Review.","authors":"Dan-Dan Wang, Shi-Guang Ren, Rui Hu, Hui-Lan Zhai, Fen Xie, Lu Jiang, Wen-Lei Huang, Xue-Qin Li","doi":"10.2147/IJGM.S502142","DOIUrl":"https://doi.org/10.2147/IJGM.S502142","url":null,"abstract":"<p><p>Inflammatory bowel disease (IBD) encompasses chronic inflammatory conditions of the digestive tract, including Crohn's disease and ulcerative colitis. Fatigue is one of the common and important extraintestinal symptoms in IBD patients, which significantly affects the patient's ability to work, daily life, social activities, emotional state, and cognitive function. Although the impact of fatigue on patients' quality of life cannot be ignored, medical professionals still have limited knowledge of its concepts, assessment tools, influencing factors, and non-pharmacological interventions, which may lead to neglect and inadequate management of the symptoms. The purpose of this article is to review the definition and epidemiological characteristics of IBD-related fatigue and to discuss the application of four commonly used fatigue assessment tools in patients with IBD. In addition, we will analyze the multiple factors that affect fatigue in IBD patients from three levels: physiological, psychological, and sociodemographic. Finally, we will assess the effectiveness of different non-pharmacological interventions in alleviating fatigue in people with IBD and make corresponding clinical recommendations.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1403-1413"},"PeriodicalIF":2.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11908391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Global Immune-Nutrition Inflammation Index for Predicting Coronary Slow Flow Phenomenon in Patients with Angina and No Obstructive Coronary Arteries.","authors":"Jiang Guo, Zhi-Zhen Xiang, Dan-Dan Ma","doi":"10.2147/IJGM.S516108","DOIUrl":"10.2147/IJGM.S516108","url":null,"abstract":"<p><strong>Background: </strong>Chronic inflammatory responses are involved in the initiation and development of the coronary slow flow phenomenon (CSFP). However, as a newly developed immuno-nutritional inflammation indicator, the global immune-nutrition inflammation index (GINI) has not been well elaborated for predicting CSFP in patients with angina and no obstructive coronary arteries (ANOCA).</p><p><strong>Methods: </strong>A total of 1422 individuals with ANOCA were consecutively included in this study, of whom 93 developed CSFP (CSFP group). We selected 186 (1:2 matched) age- and sex-matched patients with ANOCA and angiographically proven normal coronary blood flow as the controls (the control group). Multivariate logistic regression analysis was used to investigate predictors of CSFP in patients with ANOCA. The optimal cutoff values for GINI were calculated.</p><p><strong>Results: </strong>In total, 93 patients developed CSFP, including 29% (27) in one vessel, 28% (26) in two vessels, and 43% (40) in three vessels. Patients with CSFP had an elevated CRP level, white blood cell (WBC) count, neutrophil count, GINI, fasting blood glucose (FBG) level, and a lower lymphocyte count (P<0.05). Multivariate logistic analysis showed that the GINI and FBG levels were independent predictors of CSFP in patients with ANOCA. Moreover, we found that the more vessels affected by CSFP, the higher the GINI level. The receiver operating characteristic (ROC) showed that GINI had a better predictive value than indicators alone. When the GINI AISI was >84.1, the sensitivity and specificity were 88.2% and 58.7%, respectively [The Area Under the ROC curve (AUC): 0.774; 95% CI: 0.721-0.827; P < 0.001].</p><p><strong>Conclusion: </strong>Elevated GINI is a reliable predictor of CSFP in patients with ANOCA. Moreover, GINI had a superior predictive value compared to the indicators alone. As a newly developed inflammatory indicator, GINI can be used for further risk stratification of patients with ANOCA.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1325-1332"},"PeriodicalIF":2.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic Resonance Imaging Radiomics-Based Model for Prediction of Lymph Node Metastasis in Cervical Cancer.","authors":"Zhenjie Shi, Longlong Lu","doi":"10.2147/IJGM.S491986","DOIUrl":"10.2147/IJGM.S491986","url":null,"abstract":"<p><strong>Background: </strong>Cervical cancer remains a major cause of mortality among women globally, with lymph node metastasis (LNM) being a critical determinant of patient prognosis.</p><p><strong>Methods: </strong>In this study, MRI scans from 153 cervical cancer patients between January 2018 and January 2024 were analyzed. The patients were assigned to two groups: 103 in the training cohort; 49 in the validation cohort. Radiomic features were extracted from T2-weighted imaging (T2WI) and apparent diffusion coefficient (ADC) maps. The ITK-SNAP software enabled three-dimensional manual segmentation of the tumor regions in cervical cancer to identify regions of interest (ROIs). The collected data was divided for the training and validation of the Support Vector Machine (SVM) model.</p><p><strong>Results: </strong>The combined T2WI and ADC-based radiomics model exhibited robust diagnostic capabilities, achieving an area under the curve (AUC) of 0.804 (95% CI [0.712-0.890]) in the training cohort and an AUC of 0.811 (95% CI [0.721-0.902]) in the validation cohort. The nomogram that includes radiomic features, International Federation of Gynecology and Obstetrics (FIGO) stage, and LNM has a C-index of 0.895 (95% CI [0.821-0.962]) in the training cohort and a C-index of 0.916 (95% CI [0.825-0.987]) in the validation cohort. The C-statistics are all above 0.80, and the predicted variables are nearly aligned with the 45-degree line, consistent with the results shown in the calibration plot. This indicates that our model demonstrates good discrimination ability and satisfactory calibration.</p><p><strong>Conclusion: </strong>The MRI radiomics model, leveraging T2WI combined with ADC maps, offers an effective method for predicting LNM in cervical cancer patients.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1371-1381"},"PeriodicalIF":2.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Value of Monocyte to High-Density Lipoprotein Cholesterol Ratio for Target Lesion Revascularization in Patients With Drug-Eluting Stent Implantation.","authors":"He Meng, Xiujun Zhou, Lushan Li, Yuanying Liu, Yujie Liu, Ying Zhang","doi":"10.2147/IJGM.S502386","DOIUrl":"10.2147/IJGM.S502386","url":null,"abstract":"<p><strong>Background: </strong>Severe in-stent restenosis (ISR) following the implantation of drug-eluting stent (DES) can lead to recurrent angina pectoris or even acute myocardial infarction, thereby necessitating target lesion revascularization (TLR). Prior studies have confirmed the correlation between the monocyte to high-density lipoprotein cholesterol ratio (MHR) and ISR after DES implantation. The potential of MHR to predict TLR following DES implantation remains an area of ongoing research and may have significant clinical implications.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on a consecutive series of 474 patients undergoing DES implantation and follow-up coronary angiography between December 1, 2014 and December 1, 2022. The patients were categorized into two distinct groups according to their exposure to TLR. To assess the predictive performance of the MHR with respect to TLR, we utilized multivariate logistic regression analysis and receiver operating characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>The study revealed a significant elevation in the MHR value within the TLR group compared to the non-TLR group (12.34 vs 8.97; P < 0.001). MHR was identified as an independent predictor of TLR (Odds Ratio [OR] = 1.162; 95% Confidence Interval [CI]: 1.102-1.225). The area under the curve (AUC) was found to be 0.712 (95% CI: 0.664-0.759). When the MHR exceeded 10.98, the specificity for predicting TLR was 75.8%, and the sensitivity was 58.0%. When the MHR was incorporated into the predictive model comprising established risk factors, there was a notable improvement in the AUC, from 0.689 to 0.749 (P < 0.001). Additionally, there was a significant categorical net reclassification improvement (NRI) of 0.183 (P < 0.001) and an integrated discrimination improvement (IDI) of 0.074 (P < 0.001).</p><p><strong>Conclusion: </strong>The MHR functions as a predictor for TLR subsequent to DES implantation. Incorporating MHR into the predictive model improves the model's accuracy, indicating its potential value for clinical application.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1383-1391"},"PeriodicalIF":2.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Impact Factors and Efficacy of N-Butylphthalide (NBP) on Functional Outcomes Following Mechanical Thrombectomy in Stroke Patients.","authors":"Xinxing Wang, Doudou Shi, Yali Liu, Yifan Liu","doi":"10.2147/IJGM.S506806","DOIUrl":"10.2147/IJGM.S506806","url":null,"abstract":"<p><strong>Background: </strong>Ischemic stroke was a major cause of mortality and disability worldwide. Mechanical thrombectomy (MT) has improved acute ischemic stroke treatment by restoring blood flow in large vessel occlusions. Yet, reperfusion injury remains a challenge, necessitating adjunctive neuroprotective strategies to enhance recovery. N-butylphthalide (NBP), with its anti-inflammatory and antioxidative properties, may improve functional outcomes post-MT.</p><p><strong>Methods: </strong>This retrospective study analyzed 120 ischemic stroke patients treated with MT at a single institution from December 2020 to December 2022. Patients were divided into a routine care group (n = 56) and an NBP treatment group (n = 64). Baseline characteristics, comorbidities, and biochemical profiles were assessed. Functional outcomes were measured by the modified Rankin Scale (mRS) at 90 days. Statistical analysis included correlation and logistic regression to identify factors influencing recovery.</p><p><strong>Results: </strong>Among the NBP group, a significantly higher percentage achieved favorable mRS scores (0-2) compared to the routine care group (62.50% vs 37.50%, P = 0.006). Smoking (OR 0.320, P = 0.021), diabetes (OR 0.246, P = 0.022), and elevated hs-CRP levels (OR 0.407, P = 0.004) were identified as negative predictors of functional recovery. Conversely, NBP treatment significantly improved outcomes (OR 3.248, P = 0.008).</p><p><strong>Conclusion: </strong>The study supports the potential of NBP as an effective adjunctive therapy in improving recovery following MT in ischemic stroke patients. Modifiable factors such as smoking and diabetes, along with elevated hs-CRP, negatively influence outcomes, highlighting the importance of comprehensive management.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1311-1324"},"PeriodicalIF":2.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune Cell Crisis and Excess Histopathological Features During the Development and Progression of <i>H. pylori</i> Infection in the Gastric Mucosa.","authors":"Su-Nan Wang, Yang-Kun Wang, Ping Li, Ling-Chao Kong, Wei-Yi Deng, Bo Jiang, Ying-Ying Li","doi":"10.2147/IJGM.S474925","DOIUrl":"10.2147/IJGM.S474925","url":null,"abstract":"<p><strong>Objective: </strong>To investigate immune cell crisis and excess histopathological features during the development and progression of <i>H. pylori</i> infection in the gastric mucosa.</p><p><strong>Methods: </strong>One thousand two hundred and seventy-six cases of <i>H. pylori</i> infection were examined by endoscopic biopsy and endoscopic submucosal dissection (ESD) resection. The relationship between epithelial cells and immune cells and the pathological features of immune cell dysfunction and excess tissue were observed. The 1276 cases of mucosal biopsy of <i>H. pylori</i> infection and ESD resection were included. Among them, 39 were ESD excision and 1237 were gastric mucosal biopsy specimens. Among them, there were 896 cases of antrum infection, 274 cases of stomach body infection, and 106 cases of infection in antrum and body of stomach. Three to five pieces of mucosal tissue were extracted from each site. There were 789 males (61.8%) and 454 females (35.6%). There were 724 cases (56.7%) with age ≤60 and 552 cases (43.3%) with age >60.</p><p><strong>Results: </strong>During the occurrence and development of <i>H. pylori</i> infection, there were not only spider-like vacuolar degeneration of surface epithelial cells, compensatory cervical mucous cell proliferation, proliferation disorder of stem cells in proliferating areas, and neoplastic proliferation of gastric mucosal epithelial cells, but also morphological changes of immune cells in the process of occurrence and development of <i>H. pylori</i> infection. First, neutrophils that rapidly respond and attack the infection; however, neutrophils quickly display functional deficiencies, forming mucosal erosion and micro-abscesses. Then, it enters a phase of immune cell crisis. The immune defense is adjusted. The rapid proliferation of lymphocytes leads to the formation of lymphocyte immunity and the formation of lymphocyte follicle-like structures. In this stage, the lesions are wide and deep, the duration is long, and the number of patients is large. Persistent <i>H. pylori infection</i> can result in abnormal proliferation and transformation of gastric mucosal epithelial cells and immune cells and gastric adenocarcinoma and MALT lymphoma.</p><p><strong>Conclusion: </strong>Understanding the immune cell crisis and excess histopathological features during the occurrence and development of <i>H. pylori</i> infection is important for controlling the occurrence and development of gastric cancer and lymphoid system tumors via immune intervention.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"1345-1357"},"PeriodicalIF":2.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}