International Journal of General Medicine最新文献

筛选
英文 中文
Application and Evaluation of Spiral CT in the Diagnosis of Congenital Heart Disease in Children. 螺旋CT在儿童先天性心脏病诊断中的应用与评价。
IF 2.1 4区 医学
International Journal of General Medicine Pub Date : 2025-04-23 eCollection Date: 2025-01-01 DOI: 10.2147/IJGM.S506437
Wenjuan Chen, Peng Pan
{"title":"Application and Evaluation of Spiral CT in the Diagnosis of Congenital Heart Disease in Children.","authors":"Wenjuan Chen, Peng Pan","doi":"10.2147/IJGM.S506437","DOIUrl":"https://doi.org/10.2147/IJGM.S506437","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to explore the application of spiral CT in the diagnosis of congenital heart disease in children and evaluate its clinical value.</p><p><strong>Methods: </strong>The study included children diagnosed and treated at our hospital from January 2021 to October 2023 as research subjects. After excluding children who did not meet the complete inclusion criteria, a total of 60 cases were finally included. General data of all children were collected and summarized. Spiral CT and echocardiography were performed on all children, and the diagnostic results of both were compared with surgical findings to analyze and evaluate their application effectiveness.</p><p><strong>Results: </strong>Spiral CT detected 39 cases of intracardiac anomalies, 30 cases of abnormal connections of the great vessels, and 66 cases of extracardiac vascular anomalies, while echocardiography detected 33 cases of intracardiac anomalies, 29 cases of abnormal connections of the great vessels, and 43 cases of extracardiac vascular anomalies. Compared with surgical results, the detection rate of extracardiac vascular anomalies (98.59%) and the overall cardiovascular anomaly detection rate (98.54%) by spiral CT were significantly higher than those by echocardiography, with P<0.05.</p><p><strong>Conclusion: </strong>Spiral CT is a high-resolution, rapid, and safe imaging technique. Compared with traditional echocardiography, it is not only superior in diagnostic accuracy but also faster in imaging speed. It can clearly display the anatomical structure and spatial relationships of lesions, making it of great value in the diagnosis of congenital heart disease in children. It is suitable for clinical promotion and use.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2217-2224"},"PeriodicalIF":2.1,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Nomogram for Predicting the Risk of Death in Patients with Prolonged Hospital Stays in Internal Medicine Wards: A Retrospective Study. 预测内科病房长时间住院患者死亡风险的Nomogram:一项回顾性研究。
IF 2.1 4区 医学
International Journal of General Medicine Pub Date : 2025-04-23 eCollection Date: 2025-01-01 DOI: 10.2147/IJGM.S515677
Huiqing Pan, Xinran Liu, Bing Wang, Hua Hang, Sheng Ye
{"title":"A Nomogram for Predicting the Risk of Death in Patients with Prolonged Hospital Stays in Internal Medicine Wards: A Retrospective Study.","authors":"Huiqing Pan, Xinran Liu, Bing Wang, Hua Hang, Sheng Ye","doi":"10.2147/IJGM.S515677","DOIUrl":"https://doi.org/10.2147/IJGM.S515677","url":null,"abstract":"<p><strong>Objective: </strong>Prolonged hospital length of stay (PLOS) is associated with adverse outcomes, including increased healthcare costs, higher risk of complications, and increased mortality. This study aimed to investigate the relationship between PLOS and mortality among patients hospitalized in internal medicine wards and to develop a nomogram to predict the risk of death in this patient population.</p><p><strong>Methods: </strong>This retrospective study included patients hospitalized for more than 30 days in internal medicine wards between January 1, 2022, and December 31, 2022. Multivariate logistic regression analysis was used to identify independent risk factors for in-hospital mortality. The nomogram was constructed based on the independent factors. Calibration curves and receiver operating characteristic (ROC) curves were used to evaluate the predictive performance of the nomogram, and decision curve analysis (DCA) was conducted to assess its clinical utility.</p><p><strong>Results: </strong>A total of 1042 patients were included in this study, resulting in a mortality rate of 10.17%. Multivariate logistic regression analysis showed that age (<i>OR</i>=1.043, 95% CI: 1.026-1.061, <i>P</i><0.001), tumor (<i>OR</i>=2.274, 95% CI: 1.441-3.589, <i>P</i><0.001), blood transfusion (<i>OR</i>=4.667, 95% CI: 2.932-7.427, <i>P</i><0.001), ADL score (<i>OR</i>=0.966, 95% CI: 0.952-0.981, <i>P</i><0.001) and MNA-SF score (<i>OR</i>=0.825, 95% CI: 0.760-0.895, <i>P</i><0.001) as independent risk factors for mortality among patients hospitalized in internal medicine wards. The nomogram constructed using these factors demonstrated well discriminatory ability, with an AUC of 0.803 (95% CI: 0.761-0.846). Decision curve analysis further validated the clinical utility of the nomogram, highlighting its potential to improve risk assessment and guide clinical decision-making.</p><p><strong>Conclusion: </strong>This nomogram effectively evaluates the risk of death for prolonged hospitalization of patients in internal medicine wards and holds significant potential for promotion in clinical practice.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2225-2235"},"PeriodicalIF":2.1,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Low-Energy and High-Energy Early Enteral Nutrition Strategies on Patient Outcomes in Acute Kidney Injury. 低能量和高能量早期肠内营养策略对急性肾损伤患者预后的影响。
IF 2.1 4区 医学
International Journal of General Medicine Pub Date : 2025-04-21 eCollection Date: 2025-01-01 DOI: 10.2147/IJGM.S505545
Ajuan Hou, Caiping Zhao
{"title":"Impact of Low-Energy and High-Energy Early Enteral Nutrition Strategies on Patient Outcomes in Acute Kidney Injury.","authors":"Ajuan Hou, Caiping Zhao","doi":"10.2147/IJGM.S505545","DOIUrl":"https://doi.org/10.2147/IJGM.S505545","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the impact of different early enteral nutrition (EEN) strategies on nutritional indicators and immune function in patients with acute kidney injury (AKI) undergoing continuous renal replacement therapy (CRRT).</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 60 CRRT-treated AKI patients from January 2020 to March 2024, divided into a control group (high-energy EEN) and an observation group (low-energy EEN). Nutritional indicators (albumin, prealbumin, hemoglobin), immune function indicators (CD4+, CD8+, immunoglobulin A, G, M), and clinical outcomes (ICU stay duration, CRRT duration, gastric retention) were compared.</p><p><strong>Results: </strong>Before treatment, there were no significant differences in nutritional indicators between the two groups (P > 0.05). After 7 days of treatment, the observation group showed significantly greater improvements in all nutritional indicators (P < 0.05). Immune function indicators also improved significantly in the observation group (P < 0.05). Additionally, the observation group had significantly shorter ICU and CRRT durations compared to the control group (P < 0.05).</p><p><strong>Conclusion: </strong>Compared to high-energy EEN guidance, low-energy EEN guidance significantly improves nutritional status and enhances immune function in CRRT-treated AKI patients.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2207-2215"},"PeriodicalIF":2.1,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12024476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Sevoflurane Combined with Propofol Anesthesia on Hemodynamics and Pain in Elderly Patients Undergoing Radical Surgery for Malignant Tumors. 七氟醚联合异丙酚麻醉对老年恶性肿瘤根治术患者血流动力学和疼痛的影响。
IF 2.1 4区 医学
International Journal of General Medicine Pub Date : 2025-04-18 eCollection Date: 2025-01-01 DOI: 10.2147/IJGM.S509897
Ling Qi, Xue-Cai Yi, Chen Li, Yan Li
{"title":"The Effect of Sevoflurane Combined with Propofol Anesthesia on Hemodynamics and Pain in Elderly Patients Undergoing Radical Surgery for Malignant Tumors.","authors":"Ling Qi, Xue-Cai Yi, Chen Li, Yan Li","doi":"10.2147/IJGM.S509897","DOIUrl":"https://doi.org/10.2147/IJGM.S509897","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the effects of sevoflurane combined with propofol anesthesia on hemodynamics, stress response, pain, and cognitive function in elderly patients undergoing radical surgery for malignant tumors.</p><p><strong>Methods: </strong>A retrospective analysis was performed on 100 elderly patients undergoing radical surgery for malignant tumors at our hospital from February 2023 to June 2024. The patients were divided into two groups based on anesthesia method: the control group (n=50, propofol anesthesia) and the observation group (n=50, sevoflurane combined with propofol anesthesia). Anesthesia parameters, stress response indicators (norepinephrine, epinephrine, renin), hemodynamic indicators (heart rate, mean arterial pressure, systolic and diastolic blood pressure), pain levels (visual analog scale), cognitive function (Mini-Mental State Examination), and adverse reactions were compared between the two groups.</p><p><strong>Results: </strong>The observation group showed significantly shorter times to loss of consciousness, awakening, and extubation compared to the control group (P < 0.05). Stress markers (norepinephrine, epinephrine, renin) were less elevated in the observation group compared to the control group five minutes after extubation (P < 0.05). Hemodynamic parameters (heart rate, mean arterial pressure, systolic and diastolic blood pressure) were more stable in the observation group (P < 0.05). The visual analog scale (VAS) scores were lower in the observation group at 12 and 24 hours postoperatively compared to the control group (P < 0.05). Mini-Mental State Examination (MMSE) scores were significantly higher in the observation group at 4 and 8 hours postoperatively (P < 0.05). The incidence of adverse reactions was similar between the two groups (P > 0.05).</p><p><strong>Conclusion: </strong>Sevoflurane combined with propofol anesthesia is more effective than propofol anesthesia alone in elderly patients undergoing radical surgery for malignant tumors. It better alleviates stress responses, maintains hemodynamic stability, improves postoperative pain and cognitive function, and does not increase the risk of adverse reactions.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2197-2206"},"PeriodicalIF":2.1,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Depression in Linking Sleep Quality and Life Quality in OSAHS Patients. 抑郁症在OSAHS患者睡眠质量和生活质量之间的关系
IF 2.1 4区 医学
International Journal of General Medicine Pub Date : 2025-04-16 eCollection Date: 2025-01-01 DOI: 10.2147/IJGM.S516422
Jinglan Chen, Shiqi Xie, Jianrong Zhou, Yi Wen, Xia Yang, Feng Xing, Xirong Wu
{"title":"The Role of Depression in Linking Sleep Quality and Life Quality in OSAHS Patients.","authors":"Jinglan Chen, Shiqi Xie, Jianrong Zhou, Yi Wen, Xia Yang, Feng Xing, Xirong Wu","doi":"10.2147/IJGM.S516422","DOIUrl":"https://doi.org/10.2147/IJGM.S516422","url":null,"abstract":"<p><strong>Purpose: </strong>OSAHS patients' quality of life is significantly impacted by poor sleep. This study examines the mediating role of depression in the relationship between sleep quality and life quality among OSAHS patients.</p><p><strong>Patients and methods: </strong>Convenience sampling was applied to gather participants at a Chongqing tertiary hospital. Participants filled out questionnaires measuring their quality of life, depression, and sleep quality. Sleep quality was gauged by the Pittsburgh Sleep Quality Index (PSQI), depression was assessed by the Patient Health Questionnaire (PHQ-9), and quality of life was assessed by the Quebec Sleep Questionnaire (QSQ). Mediation analysis was performed via SPSS PROCESS.</p><p><strong>Results: </strong>The study found that depressive symptoms (r=-0.705, p<0.01) and sleep quality (r=-0.578, p<0.01) were adversely associated with quality of life in OSAHS patients. Depressive symptoms were found to significantly mediate the relationship between sleep quality and quality of life in OSAHS patients (Bootstrap 95% CI -0.0992, -0.0483), with 49.55% of the effect size attributable to the pathway from sleep quality to depression to quality of life.</p><p><strong>Conclusion: </strong>Sleep quality and depressive symptoms are important indicators of quality of life in OSAHS patients. Depression serves as a partial mediator (In this study, the mediating factor refers to the element that controls the association between quality of life and sleep quality) in the relationship between sleep quality and quality of life. Interventions aimed at enhancing sleep quality and alleviating depressive symptoms may lead to an improved quality of life for OSAHS patients.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2185-2195"},"PeriodicalIF":2.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Trimetazidine Combined with Atorvastatin on Cardiac Function in Patients with Stable Angina Pectoris of Coronary Heart Disease. 曲美他嗪联合阿托伐他汀对稳定型冠心病心绞痛患者心功能的影响。
IF 2.1 4区 医学
International Journal of General Medicine Pub Date : 2025-04-16 eCollection Date: 2025-01-01 DOI: 10.2147/IJGM.S515436
Na Zhang, Yuanyuan Ren, Donghui Qin, Xue Yang, Zhuo Chen, Li Zhao
{"title":"Effects of Trimetazidine Combined with Atorvastatin on Cardiac Function in Patients with Stable Angina Pectoris of Coronary Heart Disease.","authors":"Na Zhang, Yuanyuan Ren, Donghui Qin, Xue Yang, Zhuo Chen, Li Zhao","doi":"10.2147/IJGM.S515436","DOIUrl":"https://doi.org/10.2147/IJGM.S515436","url":null,"abstract":"<p><strong>Objective: </strong>Growing evidence suggests that metabolic modulation combined with lipid-lowering therapy may provide synergistic benefits in coronary heart disease (CHD). This study aimed to evaluate the effects of trimetazidine combined with atorvastatin on cardiac function and inflammatory responses in stable angina pectoris.</p><p><strong>Methods: </strong>This retrospective study analyzed 100 CHD patients with stable angina (2019 ESC criteria) treated at the Third Affiliated Hospital of Qiqihar Medical College from 2021-2024. Patients were categorized into two groups based on prescription records, control group (n=50), receiving atorvastatin 20 mg/day, and an observation group (n=50), receiving atorvastatin 20 mg/day plus trimetazidine 20 mg TID. Outcomes included angina characteristics, lipid profile, endothelial function (NO/ET-1), specified inflammatory markers (hs-CRP, TNF-α), cardiac function (LVEF, NT-proBNP), and safety.</p><p><strong>Results: </strong>The observation group had a significantly higher overall response rate (94.0% vs 80.0%, P<0.05). Both groups showed reduced angina frequency and duration post-treatment, with more pronounced improvements in the observation group (P<0.05). Chest pain severity (VAS) also decreased more significantly in the observation group, indicating superior efficacy (P<0.05). Lipid metabolism improved in both groups, with greater reductions in TC, TG, and LDL-C and a more substantial HDL-C increase in the observation group (P<0.05). Endothelial function markers improved, with lower ET-1, TNF-α, and hs-CRP levels and higher NO levels, showing more significant changes in the observation group (P<0.05). Cardiac function parameters improved in both groups, with greater reductions in LVEDD and NT-proBNP and greater increases in LVEF and 6MWD in the observation group (P<0.05). Adverse effects were low and comparable between groups (8.0% vs 6.0%, P>0.05).</p><p><strong>Conclusion: </strong>The trimetazidine-atorvastatin combination demonstrates synergistic effects in improving angina symptoms, lipid metabolism, and cardiac function in stable CHD, with additional benefits in endothelial protection and measured inflammatory regulation. These findings support its consideration as adjunctive therapy, though further validation of broader inflammatory impacts is warranted.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2173-2183"},"PeriodicalIF":2.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Significance of RUNX3 Expression Levels in the Prognosis of Severe Acute Pancreatitis. RUNX3表达水平在重症急性胰腺炎预后中的意义
IF 2.1 4区 医学
International Journal of General Medicine Pub Date : 2025-04-15 eCollection Date: 2025-01-01 DOI: 10.2147/IJGM.S508172
Ya-Hui Cheng, Lun-Fei Cao
{"title":"The Significance of RUNX3 Expression Levels in the Prognosis of Severe Acute Pancreatitis.","authors":"Ya-Hui Cheng, Lun-Fei Cao","doi":"10.2147/IJGM.S508172","DOIUrl":"https://doi.org/10.2147/IJGM.S508172","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the expression levels of RUNX3 in patients with severe acute pancreatitis (SAP) and its impact on disease progression.</p><p><strong>Methods: </strong>Healthy individuals undergoing physical examinations during the same period were selected as a control group. General patient data were analyzed and compared. Enzyme-linked immunosorbent assay (ELISA) was used to detect the expression levels of RUNX3, and differences in RUNX3 levels between the groups were compared.</p><p><strong>Results: </strong>Comparison of general characteristics showed no statistically significant differences in sex, age, body mass index (BMI), history of diabetes, hypertension, coronary artery disease, etiology, or prevalence of fatty liver among the groups (P > 0.05). The time from onset to admission and the length of hospital stay were significantly higher in the severe group compared to the mild group (P = 0.001). The severe group also exhibited significantly higher white blood cell counts (WBC), procalcitonin (PCT), C-reactive protein (CRP), lipase (LPS), and APACHE II scores (P = 0.001). RUNX3 levels were 97.67 ± 31.03 in the SAP group, significantly lower than 137.22 ± 53.07 in the mild group and 217.55 ± 76.59 in the control group (P < 0.05). Pearson correlation analysis revealed a negative correlation between RUNX3 levels and APACHE II scores in patients with acute pancreatitis (r = -0.613, P < 0.0152). RUNX3 levels in the poor prognosis group were significantly lower than those in the good prognosis group (P < 0.05). ROC curve analysis indicated that the area under the curve for RUNX3 levels in predicting the prognosis of acute pancreatitis was 0.835, with an optimal cutoff value of 162.31 pg/mL, a sensitivity of 90.00%.</p><p><strong>Conclusion: </strong>RUNX3 expression levels are significantly reduced in patients with SAP and are negatively correlated with disease severity, making them a potential biomarker for assessing and predicting the prognosis of acute pancreatitis.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2133-2139"},"PeriodicalIF":2.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Follow-Up in Primary Care After Ischemic Stroke - Insights From the Nor-COAST Study. 缺血性卒中后初级保健的随访——来自norcoast研究的见解。
IF 2.1 4区 医学
International Journal of General Medicine Pub Date : 2025-04-15 eCollection Date: 2025-01-01 DOI: 10.2147/IJGM.S508154
Ingvild Svorkdal Sande, Kamilla Lind Helgheim, Ingvild Saltvedt, Tove Garåsen Røsstad, Olav Spigset, Hanne Ellekjær, Mari Nordbø Gynnild
{"title":"Follow-Up in Primary Care After Ischemic Stroke - Insights From the Nor-COAST Study.","authors":"Ingvild Svorkdal Sande, Kamilla Lind Helgheim, Ingvild Saltvedt, Tove Garåsen Røsstad, Olav Spigset, Hanne Ellekjær, Mari Nordbø Gynnild","doi":"10.2147/IJGM.S508154","DOIUrl":"https://doi.org/10.2147/IJGM.S508154","url":null,"abstract":"<p><strong>Background: </strong>There is limited information on follow-up routines for adequate poststroke care after discharge from hospital.</p><p><strong>Purpose: </strong>This study aimed to assess the likelihood of general practitioner (GP) follow-up within 18 months after an ischemic stroke and to identify clinical factors influencing follow-up frequency.</p><p><strong>Patients and methods: </strong>Home-dwelling patients admitted to St. Olavs University Hospital with ischemic stroke between 2015 and 2017 were included. Follow-up was assessed by linkage to administrative health data, tracking GP visits over the 18-month period post discharge.</p><p><strong>Results: </strong>In total, 278 of the 302 patients included (92%) had at least one consultation, with a mean time to first consultation of 64 days (SD 96). Of these 278 patients, the cumulative probability of a consultation within 30, 90, 365, and 540 days was 56%, 81%, 96%, and 100%, respectively. The mean number of consultations during the 18-month follow-up was 6.2 (SD 6.7). Factors associated with a lower probability of consultation within the first 90 days included use of home care services (HR 0.56, 95% CI 0.41-0.77), disability (HR 0.70, 95% CI 0.61-0.79), frailty (HR 0.82, 95% CI 0.72-0.94), and cognitive impairment (HR 0.85, 95% CI 0.75-0.97). Additionally, older age (coefficient -0.09 per year, 95% CI -0.16 to -0.02), use of home care services (coefficient -2.34, 95% CI -4.52 to -0.15), and cognitive impairment (coefficient -0.77, 95% CI -1.46 to -0.09) were associated with fewer consultations.</p><p><strong>Conclusion: </strong>Most patients had at least one GP consultation within 18 months poststroke. However, vulnerable patients with advanced age, frailty, disability, and cognitive impairment may be at risk of suboptimal follow-up after ischemic stroke.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2141-2150"},"PeriodicalIF":2.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms of Resistance to ALK Inhibitors and Corresponding Treatment Strategies in Lung Cancer. 肺癌对ALK抑制剂的耐药机制及治疗策略
IF 2.1 4区 医学
International Journal of General Medicine Pub Date : 2025-04-15 eCollection Date: 2025-01-01 DOI: 10.2147/IJGM.S512395
Jiajun Xie, Yinghao Gao, Weiguo Xu, Jing Zhu
{"title":"Mechanisms of Resistance to ALK Inhibitors and Corresponding Treatment Strategies in Lung Cancer.","authors":"Jiajun Xie, Yinghao Gao, Weiguo Xu, Jing Zhu","doi":"10.2147/IJGM.S512395","DOIUrl":"https://doi.org/10.2147/IJGM.S512395","url":null,"abstract":"<p><p>Lung cancer continues to be a leading cause of cancer-related mortality and morbidity worldwide. The echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) fusion gene accounts for approximately 3%-5% of gene mutation types. Targeted therapies for ALK mutations have made significant advancements in recent decades, enabling a considerable number of patients to achieve the goal of five-year survival benefits. However, overcoming the drug resistance that arises with current ALK tyrosine kinase inhibitors (TKIs) remain a major challenge in ALK-targeted therapies. In this review, we briefly discuss the primary and secondary mechanisms of resistance to ALK-TKIs, and explore treatment strategies based on progressive resistance models. Meanwhile, novel drugs and combination therapies are being actively researched and developed to address these challenges. The aim is to offer new insights into the mechanisms of resistance and the corresponding treatment strategies to ALK inhibitors.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2151-2171"},"PeriodicalIF":2.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum: KRT19 is a Promising Prognostic Biomarker and Associates with Immune Infiltrates in Serous Ovarian Cystadenocarcinoma [Corrigendum]. KRT19是一种有希望的预后生物标志物,与浆液性卵巢囊腺癌的免疫浸润有关[勘误]。
IF 2.1 4区 医学
International Journal of General Medicine Pub Date : 2025-04-14 eCollection Date: 2025-01-01 DOI: 10.2147/IJGM.S533631
{"title":"Erratum: KRT19 is a Promising Prognostic Biomarker and Associates with Immune Infiltrates in Serous Ovarian Cystadenocarcinoma [Corrigendum].","authors":"","doi":"10.2147/IJGM.S533631","DOIUrl":"https://doi.org/10.2147/IJGM.S533631","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.2147/IJGM.S419235.].</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"2131-2132"},"PeriodicalIF":2.1,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12008559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信