International Journal of General Medicine最新文献

{"title":"Using Pathomics-Based Model for Predicting Positive Surgical Margins in Patients with Esophageal Squamous Cell Carcinoma: A Comparative Study of Decision Tree and Nomogram.","authors":"Ze Tang, Shiyun Feng, Qing Liu, Yunze Ban, Yan Zhang","doi":"10.2147/IJGM.S495296","DOIUrl":"10.2147/IJGM.S495296","url":null,"abstract":"<p><strong>Objective: </strong>Esophageal squamous cell carcinoma (ESCC) has a high incidence and mortality rate. Postoperative positive surgical margins (PSM) often correlate with poor prognosis. This study aims to develop and validate a predictive model for PSM positivity in ESCC patients, with the potential to guide preoperative planning and improve patient outcomes.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 1776 patients who underwent esophageal cancer surgery at the First Affiliated Hospital of Jilin University between January 2015 and December 2023. Patients with visible residual tumors (R2) or microscopic residual tumors (R1) at the surgical margins were classified as having PSM. High-dimensional pathological features were extracted from digital pathological sections using CellProfiler software. The selected features were used to develop a predictive model based on decision trees and generalized linear regression, and the model was validated in an independent cohort. Clinically significant pathological factors (P < 0.05) were included in multivariate logistic regression for further validation. The model's performance was assessed using calibration curves and receiver operating characteristic (ROC) curves, generated with the Bootstrap method. Decision curve analysis (DCA) was employed to evaluate the clinical utility of the predictive model.</p><p><strong>Results: </strong>A total of 229 patients (12.89%) were diagnosed with PSM. Logistic regression analysis identified multifocal lesions, vascular invasion, and pathomics-based features as independent predictors of PSM. The predictive model, represented by a decision tree, demonstrated good discrimination with an area under the ROC curve of 0.899 (95% CI: 0.842-0.956, P < 0.001), and a strong calibration curve between the predicted probability and the actual probability. Additionally, the nomogram demonstrated slightly inferior discrimination with an area under the ROC curve of 0.803 (95% CI: 0.734-0.872, P < 0.001) in the training cohort.</p><p><strong>Conclusion: </strong>Our study successfully established and validated a pathology-based predictive model for PSM risk, which could enhance preoperative evaluation and inform treatment strategies for ESCC.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"17 ","pages":"5869-5882"},"PeriodicalIF":2.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prognostic Value of Systemic Immune-Inflammation Index Supporting Age-Adjusted Charlson Comorbidity Index in Non-Small Cell Lung Cancer Patients with First-Line Platinum-Based Chemotherapy.","authors":"Yi-Yun Sheng, Qing Zhu, Qian-Bin Dai, Yu-Jie Gao, Yun-Xue Bai, Mei-Fang Liu","doi":"10.2147/IJGM.S486674","DOIUrl":"10.2147/IJGM.S486674","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to examine the association between the systemic immune-inflammation index (SII) (ie, neutrophil count × platelet count/lymphocyte count), the age-adjusted Charlson comorbidity index (ACCI), and overall survival (OS) in non-small cell lung cancer (NSCLC) patients undergoing first-line platinum-based chemotherapy (PBC), with a particular emphasis on the role of SII in supporting ACCI.</p><p><strong>Patients and methods: </strong>This retrospective study enrolled 353 cases treated between July 2013 and November 2020. Mann-Whitney <i>U</i>-test and Kruskal-Wallis test were employed to compare parameters between high and low SII groups. The cut-off values for SII and ACCI were determined using the X-tile software. Prognostic significance was evaluated through the utilization of Kaplan-Meier curves and Cox regression analysis.</p><p><strong>Results: </strong>In a univariate Cox regression analysis, sex, age, TNM, lymph node, therapy, SII, and ACCI were associated with OS. After adjusting for confounders in the multivariate analysis, TNM, SII, and ACCI remained independent prognostic factors for OS. Furthermore, within the ACCI subgroups (ACCI<5 or ACCI≥5), a high SII was significantly associated with an increased risk of death. Patients with both a high ACCI and a high SII had the highest risk of death (<i>p</i> < 0.001), with a loss of approximately ten months of survival during the first three years after treatment.</p><p><strong>Conclusion: </strong>SII was proven to be valuable in predicting OS and, when complemented by ACCI, can help tailor prognostic assessment and treatment strategies in assessing the survival of NSCLC patients with first-line PBC.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"17 ","pages":"5837-5848"},"PeriodicalIF":2.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Glucose-Phosphate Ratio on Admission as a Potential Biomarker for Severity, Functional Outcome, and Recurrence in Acute Ischemic Stroke.","authors":"Jie Li, Wenyang Ma, Wuzhuang Tang, Kaixuan Yang, Hongqiu Gu, Junfeng Shi, Feng Chen, Chenhan Xu, Shiyuan Gu, Yongjun Wang","doi":"10.2147/IJGM.S467156","DOIUrl":"10.2147/IJGM.S467156","url":null,"abstract":"<p><strong>Background and objective: </strong>Raised serum glucose-phosphate ratio on admission is associated with severity and poor outcome of aneurysmal subarachnoid hemorrhage and severe traumatic brain injury. However, its role in acute ischemic stroke (AIS) remains still unknown. Therefore, this prospective study aimed to investigate the association between admission serum glucose-phosphate ratio and the severity and 1-year clinical outcome of AIS.</p><p><strong>Methods: </strong>All the patients with AIS were enrolled from the Third China National Stroke Registry III. Participants were classified into four groups according to quartiles of admission serum glucose-phosphate ratio levels. Multiple regression models and restricted cubic splines were performed to evaluate the association between serum glucose-phosphate ratio and the severity and 1-year outcome of patients with AIS.</p><p><strong>Results: </strong>Among the 5,541 participants, the mean age was 62.3 years, and 69.4% patients were men. As the quartiles of admission serum glucose-phosphate ratio increased, the median NIHSS score raised, the percentage of moderate and severe stroke elevated, and rates of poor functional outcomes and recurrent stroke raised at one-year follow-up. After adjusting conventional risk factors, the highest admission serum glucose-phosphate ratio-level quartile group showed an association of poor functional outcome and stroke recurrence [OR (95% CI): 1.67 (1.28, 2.17) and HR (95% CI): 1.44 (1.08, 1.92), respectively], relative to the lowest group. Restricted cubic splines showed no significant nonlinear relationship between serum glucose-phosphate ratio and adverse outcomes of AIS.</p><p><strong>Conclusion: </strong>Admission serum glucose-phosphate ratio may be a potential blood biomarker for reflecting stroke severity, predicting poor functional outcomes, and stroke recurrence.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"17 ","pages":"5825-5836"},"PeriodicalIF":2.1,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11628315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of CEUS and CECT in the Detection of Liver Metastases of Middle and Low Rectal Cancer.","authors":"Yaoli Liu, Haimei Lun, Xuanzhang Huang, JianYuan Huang, Shangyong Zhu","doi":"10.2147/IJGM.S491165","DOIUrl":"10.2147/IJGM.S491165","url":null,"abstract":"<p><strong>Objective: </strong>To explore the imaging manifestations and clinical application value of contrast-enhanced ultrasound (CEUS) in liver metastases of middle and low rectal cancer by performing CEUS in patients. Additionally, we compared the results of CEUS with those of abdominal contrast-enhanced computed tomography (CECT) to assess the reliability of diagnosing liver metastases in patients with middle and low rectal cancer.</p><p><strong>Methods: </strong>Hepatic CEUS was performed in 1095 patients with middle and low rectal cancer, and all patients underwent abdominal CECT examinations to determine the presence or absence of liver metastases. The results of both examinations were compared to evaluate the value of hepatic CEUS for detecting liver metastases in patients with middle and low rectal cancer.</p><p><strong>Results: </strong>Among 1095 patients with middle and low rectal cancer, 132 were diagnosed with liver metastases of middle and low rectal cancer. 130 cases of liver metastases of rectal cancer were identified using hepatic CEUS, whereas 126 cases were identified using abdominal CECT. The detection rates of hepatic CEUS and abdominal CECT for liver metastases of middle and low rectal cancer showed no statistically significant differences (<i>P</i> > 0.05). The Kappa value for the diagnosis of liver metastases of middle and low rectal cancer between hepatic CEUS and abdominal CECT was 0.974 (<i>P</i> < 0.001), indicating good consistency between the two imaging modalities in detecting liver metastases of middle and low rectal cancer.</p><p><strong>Conclusion: </strong>Hepatic CEUS can be used to diagnose liver metastases in middle and low rectal cancer, providing crucial imaging evidence for clinical treatment planning. It exhibited higher sensitivity than that of abdominal CECT in diagnosing liver metastases of middle and low rectal cancer, enabling the identification of higher number of liver metastases of middle and low rectal cancer cases.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"17 ","pages":"5817-5824"},"PeriodicalIF":2.1,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11627102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Electronic Moxibustion in Patients with IDH: A Randomized Crossover Pilot Study.","authors":"Tai-Jan Liu, Heng-Chih Pan, Chin-Chan Lee, Chun-Yu Chen, I-Wen Wu, Chiao-Yin Sun, Kuo-Su Chen, Heng-Jung Hsu, Yih-Ting Chen, Cheng-Kai Hsu, Yuan-Chieh Yeh","doi":"10.2147/IJGM.S481418","DOIUrl":"10.2147/IJGM.S481418","url":null,"abstract":"<p><strong>Objective: </strong>Intradialytic hypotension (IDH), a common complication of hemodialysis (HD), is associated with increased cardiovascular risk, morbidity, and mortality. Fatigue is one of the most frequent symptoms of IDH, and deteriorates the quality of life of patients. This study aimed to evaluate the efficacy and safety of electronic moxibustion for improving IDH and its associated symptoms.</p><p><strong>Methods: </strong>We prospectively recruited 32 end-stage renal disease patients with IDH who underwent regular HD at our hospital's dialysis center between April 2019 and April 2020. A randomized, controlled, two-arm crossover trial was performed to evaluate the efficacy of adding one-hour electronic moxibustion during HD. The outcome measurements included patients' subjective assessment of the degree of fatigue, recovery time of fatigue from HD, cold intolerance before and after each intervention, frequency of IDH episodes and nursing interventions needed during HD, and blood pressure changes during HD.</p><p><strong>Results: </strong>Thirty (94%) patients completed the study. Intervention with electronic moxibustion improved the degree of fatigue (95% CI, -2.95 to -0.18, p = 0.027), specifically in patients prescribed with midodrine (95% CI, -4.20 to -0.53, p = 0.013). The short-term use of electronic moxibustion during HD did not significantly alter the frequency of IDH or reduce the degree of decrease in blood pressure. Serious adverse effects were not observed. One patient complained of heat, whereas two patients had local transient erythema and pruritus.</p><p><strong>Conclusion: </strong>Electronic moxibustion appears to be safe and efficacious for improving IDH-related fatigue, thus acting as an adjuvant therapy in HD units to enhance patient comfort and treatment adherence. Further studies with larger sample sizes are required to confirm the benefits of this novel technique.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"17 ","pages":"5793-5805"},"PeriodicalIF":2.1,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping Knowledge Landscapes and Evolving Trends of Clinical Hypnotherapy Practice: A Bibliometrics-Based Visualization Analysis.","authors":"Fei-Yi Zhao, Li Li, Peijie Xu, Gerard A Kennedy, Zhen Zheng, Yan-Mei Wang, Wen-Jing Zhang, Li-Ping Yue, Yuen-Shan Ho, Qiang-Qiang Fu, Russell Conduit","doi":"10.2147/IJGM.S497359","DOIUrl":"10.2147/IJGM.S497359","url":null,"abstract":"<p><strong>Background and aims: </strong>Increasing interest in hypnotherapy's application for a wide range of health conditions has spurred a rise in global research and publications. This study aims to visualize development patterns and current research hotspots in clinical hypnotherapy practice using scientometric methods, and to predict future research directions based on the keyword trending topics analysis.</p><p><strong>Methods: </strong>Data on hypnotherapy applications and mechanisms in clinical settings between 1994 and 2023 were gathered from Scopus, Web of Science, and PubMed, followed by analysis and visualization using the VOSviewer, <i>Bibliometrix</i> package in <i>R</i>, and CiteSpace.</p><p><strong>Results: </strong>A total of 1,549 publications were examined, indicating a steady annual increase with an average growth rate of 8.5%, reaching a high of 134 publications in 2022. The United States was the primary research hub. Collectively, 1,464 distinct institutions involving 3,195 scholars contributed to this research theme. Collaboration was predominantly confined to the same country, institution, and/or research team. High-frequency keywords included \"Pain\", \"Irritable Bowel Syndrome (IBS)\", and \"Anxiety\". Systematic review and/or meta-analysis have emerged as favored research methods. fMRI and EEG were commonly used techniques for exploring the neuropsychological mechanisms underlying hypnotherapy. \"Self-Hypnosis\", \"Virtual Reality\", and \"Meditation\" were predicted as trending topics, indicating that patients' self-managed hypnosis practice, virtual reality hypnotherapy, and exploration of the variations in mechanisms between meditation and hypnotherapy might be emerging topics and/or future key research directions within the current field.</p><p><strong>Conclusion: </strong>The use of hypnotherapy for diverse clinical issues, particularly pain, IBS, and comorbid anxiety, is garnering global attention. The evidence-based approach is widely used to assess the quality of clinical evidence for hypnotherapy. Researchers are keen on innovating traditional hetero-hypnosis, with a shift towards more cost-effective self-hypnosis and immersive virtual reality hypnotherapy. Promoting and reinforcing collaborative research efforts across countries, institutions, and teams is warranted.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"17 ","pages":"5773-5792"},"PeriodicalIF":2.1,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Correlators of Anxiety and Depression in Premature Coronary Artery Disease.","authors":"Cangtuo Li, Qiqi Hou, Quanle Han, Yuan Zhang, Jie Yu, Jianmei Wu, Hui Yang, Nan Wang, Jiawei Zhang, Kangbo Li","doi":"10.2147/IJGM.S480357","DOIUrl":"10.2147/IJGM.S480357","url":null,"abstract":"<p><strong>Purpose: </strong>The present study assessed the correlation between anxiety and depression in young and middle-aged Chinese patients with coronary artery disease (CAD).</p><p><strong>Patients and methods: </strong>This study included 313 patients diagnosed with premature CAD at the Department of Cardiology between January and July 2023. The Zung Self-Rating Anxiety/Depression Scale (SAS/SDS) was used as a standardized scale to assess mental health symptoms. A binary logistic regression model (backward) was used to analyze the correlation between anxiety and depression in premature CAD.</p><p><strong>Results: </strong>Anxiety was observed in 154 persons with a prevalence of 49.20%, with a median SAS score of 53.0 (52.00-54.00). Depression was observed in 91 patients, with a prevalence of 29.07%, with a median SDS score was 55.00 (54.00-57.00). A total of 63 (20.13%) patients had comorbid anxiety and depression. Multivariate logistic regression analysis revealed that anxiety was positively associated with severe coronary artery stenosis, systolic blood pressure (SBP), body mass index, and snoring. However, it is negatively associated with high-income levels. Depression was positively associated with age, severe coronary artery stenosis, and snoring. However, it was negatively associated with SBP. Comorbid anxiety and depression were positively associated with age, severe coronary artery stenosis, and snoring.</p><p><strong>Conclusion: </strong>For the first time, we investigated the prevalence and correlators of anxiety and depression in premature CAD. Therefore, the correlators of emotional status should be routinely evaluated in both primary and specialized care services.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"17 ","pages":"5807-5815"},"PeriodicalIF":2.1,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Effects of Bevacizumab Combined with Chemoradiotherapy on VEGF, bFGF, and Let-7 Levels in Non-Small Cell Lung Cancer and the Factors Influencing Therapeutic Efficacy: A Retrospective Cohort Study.","authors":"Xiang-Chong Luo, Peng Tang, Pei-Xiong Zhong","doi":"10.2147/IJGM.S488849","DOIUrl":"10.2147/IJGM.S488849","url":null,"abstract":"<p><strong>Objective: </strong>To explore the influence of bevacizumab combined with chemoradiotherapy on VEGF, bFGF, and Let-7 in patients with non-small cell lung cancer (NSCLC), and to analyze the factors affecting its efficacy.</p><p><strong>Methods: </strong>Totally 150 patients with non-small cell lung cancer (NSCLC) treated in our hospital from November 2018 to November 2023 were retrospectively analyzed. The serum levels of VEGF, bFGF, and Let-7 were collected and compared. Patients were divided into good efficacy and poor efficacy groups based on short-term efficacy, and logistic regression analysis was used to analyze the factors affecting efficacy.</p><p><strong>Results: </strong>Before treatment, there was no significant difference in the levels of VEGF, bFGF, and Let-7 between the two groups (P>0.05). After treatment, the levels of VEGF, bFGF, and Let-7 in both groups improved compared to before treatment, and compared with the control group, the study group had lower levels of VEGF and bFGF, and higher levels of Let-7, with statistically significant differences (all P<0.05). Multifactorial logistic regression analysis revealed that the course of disease, tumor diameter, and treatment regimen were independent factors influencing the therapeutic efficacy of NSCLC (all P<0.05).</p><p><strong>Conclusion: </strong>For patients with NSCLC, the treatment regimen of bevacizumab combined with chemoradiotherapy can achieve better efficacy, with a higher objective response rate, effectively reduce the level of vascular endothelial growth factor, increase Let-7 level, and ensure safety. In addition, disease course, tumor diameter, and treatment regimen are independent factors affecting the efficacy of NSCLC. Therefore, these factors should be comprehensively considered when formulating treatment plans to ensure the best therapeutic effect.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"17 ","pages":"5727-5735"},"PeriodicalIF":2.1,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Narrative Nursing Intervention on Patients with Specific Digestive Tract Malignancies (Esophageal, Gastric, and Intestinal Cancers): A Retrospective Study.","authors":"Yan Zheng","doi":"10.2147/IJGM.S489001","DOIUrl":"10.2147/IJGM.S489001","url":null,"abstract":"<p><strong>Objective: </strong>To explore the effect of narrative nursing intervention on patients with esophageal, gastric, and intestinal cancers.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the clinical data of 103 patients with digestive tract malignant tumors admitted to our hospital from January 2022 to January 2024. According to the nursing intervention received by the patients, they were divided into a control group (n=51) and an observation group (n=52). The control group received routine nursing intervention, while the observation group received narrative nursing intervention in addition to the routine nursing intervention. The compliance behavior, negative emotional status, self-perceived burden, quality of life, and adverse reactions of the two groups were compared.</p><p><strong>Results: </strong>After intervention, the observation group showed higher scores in medication, exercise, dietary, and emotional regulation adherence than the control group (P<0.05). Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) for negative emotions decreased in both groups, with a greater reduction in the observation group (P<0.05). Economic, physical, and emotional burden levels also decreased more in the observation group (P<0.05). Quality of life scores in physiological, social/family, emotional, and functional conditions improved more in the observation group (P<0.05). Adverse reactions, including nausea, vomiting, fatigue, pain, gastrointestinal reactions, and insomnia, were less frequent in the observation group than in the control group (P<0.05).</p><p><strong>Conclusion: </strong>Narrative nursing intervention for patients with digestive tract malignant tumors can effectively improve patient compliance behavior, alleviate negative emotions, reduce self-perceived burden, promote the improvement of patient quality of life, and reduce the occurrence of related adverse reactions. However, the study is limited by its small sample size and single-center design, which may affect the generalizability of the findings. Further research with larger and more diverse populations is recommended.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"17 ","pages":"5747-5756"},"PeriodicalIF":2.1,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological and Clinical Insights into <i>Acinetobacter baumannii</i>: A Six-Year Study on Age, Antibiotics, and Specimens.","authors":"Yousef Almoghrabi, Hussam Daghistani, Hanouf A Niyazi, Hatoon A Niyazi, Hind AbdulMajed, Noha A Juma, Noura Daffa, Noof R Helmi, Mohammed W Al-Rabia, Jawahir A Mokhtar, Bandar Hasan Saleh, Dalya M Attallah, Maram Matar, Hani Ahmed Shukri, Shahd A Moqaddam, Sara Alamoudi, Khalil K Alkuwaity, Turki Abujamel, Ahmad M Sait, Mohammed Mufrrih, Ibrahim A Al-Zahrani, Stephen O'hagan, Mazen A Ismail, Ohood S Alharbi, Hattan Jamal Momin, Ibrahim Mohammed Abu, Abdelbagi Alfadil, Karem Ibrahem","doi":"10.2147/IJGM.S489514","DOIUrl":"10.2147/IJGM.S489514","url":null,"abstract":"<p><strong>Background: </strong>This six-year retrospective study provides an in-depth analysis of the epidemiological and clinical patterns associated with <i>Acinetobacter baumannii</i> (<i>A. baumannii</i>) infections, focusing on age distribution, antibiotic resistance profiles, and specimen types.</p><p><strong>Aim: </strong>The research examines the incidence and characteristics of <i>both</i> non-Multi-Drug Resistant (non-MDR) and Multi-Drug Resistant (MDR) <i>A. baumannii</i> strains by reviewing patient records from January 2016 to December 2022.</p><p><strong>Methods: </strong>Through a statistical analysis, the study highlights the incidence rates across diverse age groups and explores the impact of antibiotic treatment regimens on infection outcomes. Additionally, it identifies the primary clinical specimen types for each strain, noting an association between non-MDR <i>A. baumannii</i> and midstream urine samples, while MDR <i>A. baumannii</i> strains were more frequently found in respiratory, wound, peripheral, and central line swaps/specimens.</p><p><strong>Results: </strong>The results indicate that in 2016, non-MDR <i>A. baumannii</i> infections were notably more frequent compared to MDR <i>A. baumannii</i> cases. However, a significant shift occurred in 2021 and 2022, with a marked decrease in non-MDR <i>A. baumannii</i> cases and an increase in MDR <i>A. baumannii</i> infections. Antibiotic susceptibility testing revealed that non-MDR strains were commonly tested against cefazolin, ceftazidime, ciprofloxacin, gentamicin, nitrofurantoin, oxacillin, piperacillin/tazobactam, and trimethoprim/sulfamethoxazole. In contrast, MDR strains were frequently tested against amikacin, cefepime, colistin, meropenem, imipenem, and tigecycline.</p><p><strong>Conclusion: </strong>This study enhances the understanding of <i>A. baumannii</i> clinical behaviour and resistance patterns, offering valuable insights to support future research and inform strategies for infectious disease management and control.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"17 ","pages":"5715-5725"},"PeriodicalIF":2.1,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11625184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}