International Journal of General Medicine最新文献

{"title":"<i>Aldehyde Dehydrogenase 2</i> rs671 Polymorphism is Associated with Susceptibility of Coronary Atherosclerosis in Patients with Hypertension.","authors":"Haisong Hou, Sina Huang, Wenyi Huang, Lingmei Huang, Zhouhua Zhang, Liu Liang","doi":"10.2147/IJGM.S501396","DOIUrl":"10.2147/IJGM.S501396","url":null,"abstract":"<p><strong>Objective: </strong>Predisposing factors for coronary atherosclerosis in hypertensive individuals are unclear. Atherosclerosis is a chronic inflammatory disease caused by lipid deposition in the blood vessels, and aldehyde dehydrogenase 2 (ALDH2) is involved in this process. The aim of this study was to assess the relationship between <i>ALDH2</i> rs671 polymorphism, serum lipids, peripheral inflammation indices (pan-immune inflammation value (PIV), systemic immune inflammation index (SII), and system inflammation response index (SIRI)) and coronary atherosclerosis risk in hypertensive patients.</p><p><strong>Methods: </strong>A total of 923 patients with hypertension (439 patients with coronary atherosclerosis, and 484 without) who were admitted to Meizhou People's Hospital between January 2019 and February 2024 were retrospectively analyzed. The relationship between <i>ALDH2</i> rs671 polymorphism, serum lipid levels, and peripheral inflammation indices and the risk of coronary atherosclerosis was analyzed.</p><p><strong>Results: </strong>There were 532 (57.6%), 337 (36.5%), and 54 (5.9%) individuals with <i>ALDH2</i> rs671 G/G, G/A, and A/A genotype, respectively. The frequency of the <i>ALDH2</i> rs671 G/A genotype, and the levels of TC, LDL-C, PIV, SII, and SIRI in patients with coronary atherosclerosis were higher than those in controls. Logistic analysis showed that body mass index (BMI) ≥24.0 kg/m² (odds ratio (OR): 1.670, 95% confidence interval (CI): 1.185-2.352, <i>p</i>=0.003), history of smoking (OR: 2.024, 95% CI: 1.263-3.243, <i>p</i>=0.003), <i>ALDH2</i> rs671 G/A genotype (OR: 1.821, 95% CI: 1.280-2.589, <i>p</i>=0.001), high TC (OR: 1.592, 95% CI: 1.021-2.485, <i>p</i>=0.040), high SII (OR: 2.290, 95% CI: 1.386-3.784, <i>p</i>=0.001), and high SIRI (OR: 1.727, 95% CI: 1.126-2.650, <i>p</i>=0.012) were associated with coronary atherosclerosis in patients with hypertension.</p><p><strong>Conclusion: </strong>Overweight (BMI ≥24.0 kg/m²), history of smoking, <i>ALDH2</i> rs671 G/A genotype, high TC, SII, and SIRI levels were associated risk factors for coronary atherosclerosis in patients with hypertension.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"681-690"},"PeriodicalIF":2.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic Challenges of Active Tuberculosis: Prevalence and Risk Factors of Co-Infection in Clinical and Microbiological Characteristics at King Abdulaziz University Hospital, Jeddah, Saudi Arabia.","authors":"Jawahir A Mokhtar, Dalya M Attallah, Asif Ahmad Jiman-Fatani, Mohammed W Al-Rabia, Mona Abdulrahman Alqarni, Bandar Hasan Saleh, Maysaa Mohammed Amboon, Tarfa A Altorki, Khalil K Alkuwaity, Turki Abujamel, Reham Kaki, Taghreed Nassir Albarakati, Hussam Daghistani, Mazen A Ismail, Ohood Alharbi, Ibrahim Ismail Mohammed Abu, Abdelbagi Alfadil, Karem Ibrahem, Mohammed Mufrrih, Ahmad M Sait","doi":"10.2147/IJGM.S494516","DOIUrl":"10.2147/IJGM.S494516","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis (TB) is a major public health issue in Saudi Arabia, particularly impacting the elderly. Immunocompromising conditions, including comorbidities, malignancies, and the use of immunosuppressive agents, are major risk factors for active TB (ATB).</p><p><strong>Objective: </strong>To analyze clinical factors and estimate mortality in TB and drug-resistant cases.</p><p><strong>Methods: </strong>This retrospective study analyzed medical records of 12,494 patients at KAUH (2019-2021), identifying 131 confirmed TB cases with comprehensive data on demographics, clinical features, comorbidities, diagnostics, and outcomes. Data were analyzed using SPSS, with chi-square and logistic regression identifying risk factors. Statistical significance was determined at a threshold of p < 0.05. In our study, logistic regression was employed to identify significant predictors of mortality among TB patients. The results were presented using beta coefficients (B) to quantify the relationship between predictors and the outcome, along with the adjusted odds ratio (AOR) to provide an interpretable measure of the strength of these associations.</p><p><strong>Results: </strong>Of the 131 TB patients involved in this paper, a higher incidence of pulmonary TB was observed among men under 30 years old. This group also showed a higher mortality rate due to comorbidities such as renal failure, human immunodeficiency virus (HIV), and autoimmune disease. The risk of mortality was heightened by 69.47% with drug susceptibility. Additionally, 19.85% of the patients had multidrug-resistant TB (MDR-TB), and 10.69% had extensively drug-resistant TB (XDR-TB). Patients undergoing hemodialysis, and those with respiratory comorbidities, cancer, diabetes, and smoking were found to have a higher mortality hazard, indicating these as significant risk factors for TB.</p><p><strong>Conclusion: </strong>This study highlights TB's prevalence and drug resistance at KAUH, emphasizing high-risk groups, including males and young adults. Effective strategies, targeted interventions, and future research are vital for reducing mortality.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"627-641"},"PeriodicalIF":2.1,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Utility of the Trajectory of Serum Bilirubin and International Normalized Ratio Values in Hepatitis B Virus-Related Acute-on-Chronic Liver Failure.","authors":"Ya-Qi Song, Xin-Yu Fu, Si-Yan Yan, Rong-Bin Qi, Yi-Jing Zhou, Jia-Wei Liang, Jin-Qiu Zhang, Li-Ping Ye, Xin-Li Mao, Shao-Wei Li","doi":"10.2147/IJGM.S490328","DOIUrl":"10.2147/IJGM.S490328","url":null,"abstract":"<p><strong>Background and aim: </strong>Acute-on-chronic liver failure (ACLF) is a rapidly progressive and highly fatal condition. Early identification of critically ill patients is crucial. Hepatitis B virus-related ACLF (HBV-ACLF), the main cause of ACLF in China, is characterized by liver failure and coagulation dysfunction. Dynamic changes in total bilirubin (TB) and international normalized ratio (INR) can reflect disease progression. This study aims to investigate the clinical application of dynamic trajectories of TB and INR in HBV-ACLF patients.</p><p><strong>Methods: </strong>Retrospective data from 194 patients at Taizhou Hospital, China (Jan 2012 - June 2023), meeting COSSH-ACLF criteria, were analyzed. A latent class mixed model (LCMM) identified three trajectory groups (declining, stable, fluctuating) based on bilirubin and INR changes. Clinical applicability of these groups was investigated.</p><p><strong>Results: </strong>The 194 patients were divided into the trajectory groups mentioned above. The declining group had lower predicted scores and a better prognosis. The stable and fluctuating groups had worse prognosis compared to the declining group (P<0.001). Artificial liver support did not improve short-term prognosis for the stable group; instead, it was a risk factor (OR 2.16, 95% CI [0.23-3.79], P=0.007). Subgroup analysis showed no interaction between predictive models and trajectory groups. Additionally, trajectory grouping improved the predictive effectiveness of existing models.</p><p><strong>Conclusion: </strong>Based on our trajectory analysis, patients with a continuous declining in bilirubin and INR values showed the best prognosis, highlighting the clinical significance of trajectory grouping in treatment decisions. Trajectory grouping can complement existing scoring models, improving predictive effectiveness.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"643-658"},"PeriodicalIF":2.1,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Prior Chronic Kidney Disease and Newly Detected eGFR Impairment at Admission on Outcomes and Prognosis of Hospitalized COVID-19 Patients - A Single-Center Cohort Study.","authors":"Michał Kania, Michał Terlecki, Krzysztof Batko, Marek Rajzer, Maciej T Malecki, Marcin Krzanowski","doi":"10.2147/IJGM.S480994","DOIUrl":"10.2147/IJGM.S480994","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>Chronic kidney disease (CKD) is a major prognostic factor in COVID-19. Little is known about the significance of newly detected renal impairment (RI) for COVID-19 patient outcomes. This study assessed the effect of prior CKD and RI at admission on in-hospital mortality in COVID-19 patients.</p><p><strong>Methods: </strong>A total of 5191 consecutive patients with COVID-19 admitted between March 6, 2020 and May 31, 2021, to the University Hospital in Krakow were analyzed. The main outcome was in-hospital death from any cause compared between the three study groups - patients with a prior history of CKD (group A), no history of CKD and eGFR on admission <60 mL/min/1,73 m2 (group B), and no history of CKD and eGFR on admission >60 mL/min/1,73 m2 (group C).</p><p><strong>Results: </strong>Of 5191 patients, 2348 (45.2%) were women and 2409 (46.4%) were older than 65 years (mean age of 61.98±16.66 years). There were 483 (9.3%) patients in group A, 1009 (22.2%) in group B and 3699 (68.5%) in group C. Groups A and B were older and had higher cardiometabolic burden compared to group C. Multivariable logistic regression showed that older age, higher CRP, WBC, D-dimer levels, HF, and being in groups A or B were associated with higher in-hospital mortality. Group B had the highest risk (OR 3.003, CI 2.298-3.926) compared to group A (OR 2.020, CI 1.636-2.494) and group C (reference).</p><p><strong>Conclusion: </strong>COVID-19 patients with prior CKD and newly detected RI have higher odds of in-hospital death compared to those with normal kidney function. Special attention is needed for newly detected RI cases in COVID-19 patients.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"593-602"},"PeriodicalIF":2.1,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11808791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut Microecological Prescription: A Novel Approach to Regulating Intestinal Micro-Ecological Balance.","authors":"Lingping Zhu, Xuefeng Yang","doi":"10.2147/IJGM.S504616","DOIUrl":"10.2147/IJGM.S504616","url":null,"abstract":"<p><p>The intestinal microecology is comprises intestinal microorganisms and other components constituting the entire ecosystem, presenting characteristics of stability and dynamic balance. Current research reveals intestinal microecological imbalances are related to various diseases. However, fundamental research and clinical applications have not been effectively integrated. Considering the importance and complexity of regulating the intestinal microecological balance, this study provides an overview of the high-risk factors affecting intestinal microecology and detection methods. Moreover, it proposes the definition of intestinal microecological imbalance and the definition, formulation, and outcomes of gut microecological prescription to facilitate its application in clinical practice, thus promoting clinical research on intestinal microecology and improving the quality of life of the population.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"603-626"},"PeriodicalIF":2.1,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11807788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting the Degree of Coronary Artery Stenosis Through Retinal Vascular Characteristics and Minimal Clinical Information.","authors":"Gong Zhang, Yaodong Ding, Tong Ma, Sijin Zhou, Bin Wang, Xiangang Chang, Yong Zeng","doi":"10.2147/IJGM.S507016","DOIUrl":"10.2147/IJGM.S507016","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the correlative relationship between fundus vascular characteristics and the severity of coronary artery stenosis.</p><p><strong>Patients and methods: </strong>A total of 1447 patients scheduled for hospitalization at Beijing Anzhen Hospital Union Hospital for coronary angiography to assess coronary artery conditions between February 2022 and December 2022 were selected. Of these, 1418 cases were ultimately obtained, with 29 cases excluded due to failure to complete coronary angiography or fundus photography. Severity of coronary artery stenosis was assessed using Gensini score. Fundus images were obtained via non-dilated fundus photography, and retinal arteriovenous diameters, arteriovenous ratios, curvatures, and dimensions were subsequently measured automatically using a computer program.</p><p><strong>Results: </strong>Pearson's correlation coefficients between the Gensini Score and fundus vascular characteristics were found to be as follows: The diameters of the superior temporal artery (-0.08), The diameters of the superior temporal vein (-0.03), the arteriovenous diameter ratio (-0.10), the retinal arterial dimension (-0.09), the retinal vein dimension (-0.06), the retinal arterial curvature (-0.06), the retinal vein curvature (-0.01). The area under the curve (AUC) for logistic regression modeling with the Gensini Score binarized (dichotomized into two categories based on a cutoff of 4 points) as the dependent variable and fundus vascular characteristics as the independent variable was 0.59 ± 0.05 (95% CI). The AUC for logistic regression modeling with the combination of fundus vascular characteristics and clinical information (sex, age, height, weight, smoking history, creatinine, total cholesterol, fasting blood glucose) yielded an AUC of 0.71 ± 0.07 (95% CI).</p><p><strong>Conclusion: </strong>Coronary stenosis is inversely correlated with fundus vascular characteristics. The combination of fundus vascular characteristics with a limited amount of clinical data (sex, age, height, weight, smoking history, creatinine, total cholesterol, fasting blood glucose) may serve as a non-invasive tool for predicting the presence or absence of severe stenosis in coronary arteries.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"585-591"},"PeriodicalIF":2.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11804228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Advances in Natural Plant Molecules for Allergic Rhinitis Immunomodulation in Vivo and in Vitro.","authors":"Bingquan Li, Boyang Dong, Liangzhen Xie, Yan Li","doi":"10.2147/IJGM.S493021","DOIUrl":"10.2147/IJGM.S493021","url":null,"abstract":"<p><p>Allergic rhinitis (AR) is a prevalent allergic disease that imposes significant economic burdens and life pressures on individuals, families, and society, particularly in the context of accelerating globalization and increasing pathogenic factors. Current clinical therapies for AR include antihistamines, glucocorticoids administered via various routes, leukotriene receptor antagonists, immunotherapy, and several decongestants. These treatments have demonstrated efficacy in alleviating clinical symptoms and pathological states. However, with the growing awareness of AR and rising expectations for improvements in quality of life, these treatments have become associated with a higher incidence of side effects and an elevated risk of drug resistance. Furthermore, the development of AR is intricately associated with dysregulation of the immune system, yet the underlying pathogenetic mechanisms remain incompletely understood. In contrast, widely available natural plant molecules offer multiple targeting pathways that uniquely modify the typical pathophysiology of AR through immunomodulatory processes. This review presents a comprehensive analysis of both in vivo and in vitro studies on natural plant molecules that modulate immunity for treating AR. Additionally, we examine their specific mechanisms of action in animal models to provide new insights for developing safe and effective targeted therapies while guiding experimental and clinical applications against AR.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"529-565"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11796455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Trends in Serum Homer1 Levels and Their Prognostic Implications in Aneurysmal Subarachnoid Hemorrhage: A Prospective Cohort Study.","authors":"Junxia Dai, Qun Lin, Liangzhi Ye, Xiaoxiang Chen, Zhiwei Li, Chuan Lu, Maohua Chen, Huajun Ba, Jun Sun, Jianyong Cai","doi":"10.2147/IJGM.S508325","DOIUrl":"10.2147/IJGM.S508325","url":null,"abstract":"<p><strong>Background: </strong>Homer scaffold protein 1 (homer1) may harbor neuroprotective effects against acute brain injury. This study aimed to investigate the prognostic role of serum homer1 in human aneurysmal subarachnoid hemorrhage (aSAH).</p><p><strong>Methods: </strong>A total of 209 patients with aSAH and 100 controls were encompassed in this prospective cohort study. Serum homer1 levels were quantified at admission in all patients, on post-aSAH days 1, 3, 5, 7, 10, and 14 in 83 patients and at recruitments in controls. The modified Fisher scale (mFisher) and World Federation of Neurological Surgeons Scale (WFNS) were used for severity assessment. Glasgow Outcome Scale (GOS) scores of 1-3 at post-aSAH 90 days indicated poor prognosis.</p><p><strong>Results: </strong>Serum homer1 levels of patients were abruptly elevated at admission, peaked at day 3, and afterwards decreased from day 5 until day 14 after aSAH, and were markedly higher during 14 days than those of controls. Serum homer1 levels were linearly and independently correlated with WFNS scores, mFisher scores, continuous GOS scores, ordinal GOS scores, poor prognosis risk and delayed cerebral ischemia (DCI) likelihood. DCI partially mediated association of serum homer1 levels with poor prognosis. The prognosis model was composed of the four independent predictors, that is serum homer1 levels, DCI, WFNS scores and mFisher scores. As demonstrated by a series of statistical methods, the model had a good performance.</p><p><strong>Conclusion: </strong>Serum homer1 levels are significantly elevated in acute phase after aSAH, and are strongly related to heightened bleeding intensity, poor 90-day prognosis and DCI. Nevertheless, associational mechanism of serum homer1 and poor prognosis mediated by DCI needs to be further deciphered.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"567-584"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11796440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relative Fat Mass and Physical Indices as Predictors of Gallstone Formation: Insights From Machine Learning and Logistic Regression.","authors":"Laifu Deng, Shuting Wang, Daiwei Wan, Qi Zhang, Wei Shen, Xiao Liu, Yu Zhang","doi":"10.2147/IJGM.S507013","DOIUrl":"10.2147/IJGM.S507013","url":null,"abstract":"<p><strong>Purpose: </strong>Gallstones (GS), a prevalent disorder of the biliary tract, markedly impair patients' quality of life. This study aims to construct predictive models employing diverse machine learning algorithms to elucidate risk factors linked to gallstone formation.</p><p><strong>Patients and methods: </strong>This study integrated data from the National Health and Nutrition Examination Survey (NHANES) with a cohort of 7868 participants from Wuxi People's Hospital and Wuxi Second People's Hospital, including 830 individuals diagnosed with gallstones. To develop our predictive model, we employed four algorithms-Logistic Regression, Gaussian Naive Bayes (GNB), Multi-Layer Perceptron (MLP), and Support Vector Machine (SVM). The models were validated internally through k-fold cross-validation and externally using independent datasets. Furthermore, we substantiated the link between relative fat mass (RFM) and gallstone formation by employing four logistic regression models, conducting subgroup analyses, and applying restricted cubic spline (RCS) curves.</p><p><strong>Results: </strong>The logistic regression algorithm demonstrated superior predictive capability for all risk factors associated with gallstone occurrence compared to other machine learning models. SHAP analysis identified RFM, weight-to-waist index (WWI), waist circumference (WC), waist-to-height ratio (WHtR), and body mass index (BMI) as prominent predictors of gallstone occurrence, with RFM emerging as the primary determinant. A fully adjusted multivariate logistic regression analysis revealed a robust positive association between RFM and gallstones. Subgroup analysis further indicated that subgroup factors did not alter the positive relationship between RFM and gallstone prevalence.</p><p><strong>Conclusion: </strong>Among the four algorithmic models, logistic regression proved most effective in predicting gallstone occurrence. The model developed in this study offers clinicians a valuable tool for identifying critical prognostic factors, facilitating personalized patient monitoring and tailored management.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"509-527"},"PeriodicalIF":2.1,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11794386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoarthritis and Degree of Fatigue are Associated with Pain Levels in Patients with Fibromyalgia Syndrome: A Cross-Sectional Study of 394 Patients.","authors":"Zihan Wang, Tianyi Lan, Yuqiao Zhang, Zijia Guo, Hongwei Yu, Guiyao Sun, Zhitian Wang, Zeran Yan, Qingwen Tao, Yuan Xu","doi":"10.2147/IJGM.S503902","DOIUrl":"10.2147/IJGM.S503902","url":null,"abstract":"<p><strong>Objective: </strong>To observe how osteoarthritis (OA) and degree of fatigue affect are associated with pain levels in patients with fibromyalgia syndrome (FMS).</p><p><strong>Methods: </strong>A cross-sectional study was conducted involving FMS patients. Data regarding the clinical features of the patients, including scores for pain-Visual Analogue Scale (VAS), Fatigue Scale-14 (FS-14) and other patient information, was collected. A multivariable logistic regression model was constructed to determine whether there is a true association between OA, degree of fatigue, and pain level in FMS patients. Restricted cubic spline (RCS) analysis was used to explore a potential non-linear relationship between degree of fatigue scores and pain levels in FMS patients. An interaction analysis based on the main regression model was performed to examine the interaction between OA and degree of fatigue.</p><p><strong>Results: </strong>Among the FMS patients, the presence of OA was identified as a risk factor associated with higher pain-VAS scores (OR=2.777, 95% CI=1.377-5.601, P=0.004); furthermore, higher degree of fatigue scores on the FS-14 were found to be significantly associated with high pain level (OR=1.145, 95% CI=1.054-1.243, P=0.001). The RCS analysis demonstrated a linear relationship between increasing FS-14 scores and an elevated risk of high pain levels among FMS patients (P-non-linear=0.119, P-overall=0.008). The interaction analyses revealed a significant association between OA and degree of fatigue, which were related to the pain level of patients with FMS synergistically.</p><p><strong>Conclusion: </strong>Patients with FMS experience coexisting OA and a high degree of fatigue, which interact synergistically, being correlated with increased pain levels.</p><p><strong>Trial registration: </strong>The study was approved by the Clinical Research Ethics Committee of the China-Japan Friendship Hospital (2022-KY-079) and registered on ClinicalTrials.gov (NCT05508516) on August 17th, 2022.</p>","PeriodicalId":14131,"journal":{"name":"International Journal of General Medicine","volume":"18 ","pages":"497-507"},"PeriodicalIF":2.1,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}