ChemBioChem最新文献_第3页

RETRACTION: High-Resolution Imaging of Human Cancer Proteins Using Microprocessor Materials. RETRACTION：使用微处理器材料对人类癌症蛋白质进行高分辨率成像。

IF 2.6 4区生物学

ChemBioChem Pub Date : 2024-11-04 DOI: 10.1002/cbic.202400798

{"title":"RETRACTION: High-Resolution Imaging of Human Cancer Proteins Using Microprocessor Materials.","authors":"","doi":"10.1002/cbic.202400798","DOIUrl":"https://doi.org/10.1002/cbic.202400798","url":null,"abstract":"Retraction: M. J. Solares, G. M. Jonaid, W. Y. Luqiu, S. Berry, J. Khadela, Y. Liang, M. C. Evans, K. J. Pridham, W. J. Dearnaley, Z. Sheng and D. F. Kelly, \"High-Resolution Imaging of Human Cancer Proteins Using Microprocessor Materials,\" ChemBioChem, 23, no. 17 (2022), e202200310, https://doi.org/10.1002/cbic.202200310. The above article, published online on 5 July 2022 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Ruben Ragg; and Wiley-VCH GmbH. The retraction has been agreed following a thorough peer review process conducted by the author's institution, Penn State. The editors' own independent investigation confirmed that density map for the p53 dimer does not align well with the model for Figures 2B and S3 A. Furthermore, it was found that the coordinate and map files associated with the article available in the Protein Data Bank [PDB accession codes 8F2I (p53 monomer), 8F2H (p53 dimer)] and Electron Microscopy Data Bank [EMDB accession codes EMD28817 (p53 monomer), EMD28816 (p53 dimer)] exhibit poor alignment throughout. In addition, the authors did not provide original research data, maps and models in question, to justify the findings. The editors' own independent investigation confirmed that the conclusions of this manuscript are not sufficiently supported. Author D. F. Kelly responded to our notice of retraction, but did not state their agreement nor disagreement. Author G. M. Jonaid agrees with the retraction. All other authors did not respond to our notice regarding the retraction.","PeriodicalId":140,"journal":{"name":"ChemBioChem","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142574927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

5'-Methoxyarmillane, a Bioactive Sesquiterpenoid Aryl Ester from the Fungus Armillaria ostoyae. 5'-Methoxyarmillane, a Bioactive Sesquiterpenoid Aryl Ester from the Fungus Armillaria ostoyae.

IF 2.6 4区生物学

ChemBioChem Pub Date : 2024-11-04 Epub Date: 2024-10-08 DOI: 10.1002/cbic.202400168

Axel M Orban, Johanna Eichberg, Michael Marner, Sandra Breuer, Maria A Patras, Ute Mettal, Till F Schäberle, Martin Rühl

{"title":"5'-Methoxyarmillane, a Bioactive Sesquiterpenoid Aryl Ester from the Fungus Armillaria ostoyae.","authors":"Axel M Orban, Johanna Eichberg, Michael Marner, Sandra Breuer, Maria A Patras, Ute Mettal, Till F Schäberle, Martin Rühl","doi":"10.1002/cbic.202400168","DOIUrl":"10.1002/cbic.202400168","url":null,"abstract":"Higher fungi of the genus Armillaria belonging to the phylum Basidiomycota produce bioactive sesquiterpenoid aryl esters called melleolides. A bioactivity-guided discovery process led to the identification of the new melleolide 5'-methoxyarmillane (1) in organic extracts from the mycelium of Armillaria ostoyae. Remarkably, supplementation of rapeseed oil to the culture medium potato dextrose broth increased the production of 1 by a factor of six during the course of the 35 days fermentation. Compound 1 was isolated and its structure elucidated by UHPLC-QTOF-HR-MS/MS and NMR spectroscopy. It showed toxicity against Madin-Darby canine kidney II (MDCK II, IC50 19.2 μg/mL, 44.1 μM) and human lung cancer Calu-3 cells (IC50 15.2 μg/mL, 34.9 μM) as well as moderate bioactivity against Mycobacterium tuberculosis (MIC 8 mg/mL, 18.4 μM) and Mycobacterium smegmatis (MIC 16 mg/mL, 36.8 μM), but not against Staphylococcus aureus, Escherichia coli, Candida albicans, and Septoria tritici. No inhibitory effects of 1 against the influenza viruses H3N2, H1N1pdm, B/Malaysia, and B/Massachusetts were observed.","PeriodicalId":140,"journal":{"name":"ChemBioChem","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140911439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Single Enzyme in Enantiocomplementary Synthesis of β-Nitroalcohols: Bidirectional Catalysis by Hydroxynitrile Lyase. β-硝基丙醇对映体互补合成中的一种单酶：羟基腈裂解酶的双向催化作用。

IF 2.6 4区生物学

ChemBioChem Pub Date : 2024-11-04 Epub Date: 2024-09-12 DOI: 10.1002/cbic.202400618

Sukadev Rana, Ayon Chatterjee, Santosh Kumar Padhi

引用次数: 0

A Water-Soluble Multifunctional Probe for Colorimetric Copper Sensing, Lysosome Labelling and Live-Cell Imaging. 用于比色铜传感、溶酶体标记和活细胞成像的水溶性多功能探针

IF 2.6 4区生物学

ChemBioChem Pub Date : 2024-11-04 Epub Date: 2024-09-12 DOI: 10.1002/cbic.202400377

Carmela Bonaccorso, Lorena Maria Cucci, Vanessa Sanfilippo, Cristina Munzone, Cosimo G Fortuna, Cristina Satriano

引用次数: 0

Integrating Biocatalysts into Metal-Organic Frameworks: Disentangling the Roles of Affinity, Molecular Weight, and Size. 将生物催化剂融入金属有机框架：厘清亲和力、分子量和尺寸的作用。

IF 2.6 4区生物学

ChemBioChem Pub Date : 2024-11-04 Epub Date: 2024-10-24 DOI: 10.1002/cbic.202400625

Raphael Greifenstein, Dhana Röhrs, Tim Ballweg, Juliana Pfeifer, Eric Gottwald, Masanari Takamiya, Matthias Franzreb, Christof Wöll

引用次数: 0

Electrochemical/Electrochemiluminescence Sensors Based on Vertically-Ordered Mesoporous Silica Films for Biomedical Analytical Applications. 基于垂直有序介孔二氧化硅薄膜的电化学/电化学发光传感器，用于生物医学分析应用。

IF 2.6 4区生物学

ChemBioChem Pub Date : 2024-11-04 Epub Date: 2024-08-02 DOI: 10.1002/cbic.202400320

Xue Fan, Jiayi Wu, Tongtong Zhang, Jiyang Liu

引用次数: 0

Redox-Activated Substrates for Enhancing Activatable Cyclopropene Bioorthogonal Reactions. 增强可活化环丙烯生物正交反应的氧化还原活化底物。

IF 2.6 4区生物学

ChemBioChem Pub Date : 2024-11-04 Epub Date: 2024-10-23 DOI: 10.1002/cbic.202400304

Wei-Siang Kao, Wei Huang, Yunlei Zhang, Kangqiao Wen, Andrea Meyer, Jorge Escorihuela, Scott T Laughlin

{"title":"Redox-Activated Substrates for Enhancing Activatable Cyclopropene Bioorthogonal Reactions.","authors":"Wei-Siang Kao, Wei Huang, Yunlei Zhang, Kangqiao Wen, Andrea Meyer, Jorge Escorihuela, Scott T Laughlin","doi":"10.1002/cbic.202400304","DOIUrl":"10.1002/cbic.202400304","url":null,"abstract":"Bioorthogonal chemistry has become a mainstay in chemical biology and is making inroads in the clinic with recent advances in protein targeting and drug release. Since the field's beginning, a major focus has been on designing bioorthogonal reagents with good selectivity, reactivity, and stability in complex biological environments. More recently, chemists have imbued reagents with new functionalities like click-and-release or light/enzyme-controllable reactivity. We have previously developed a controllable cyclopropene-based bioorthogonal ligation, which has excellent stability in physiological conditions and can be triggered to react with tetrazines by exposure to enzymes, biologically significant small molecules, or light spanning the visual spectrum. Here, to improve reactivity and gain a better understanding of this system, we screened diene reaction partners for the cyclopropene. We found that a cyclopropene-quinone pair is 26 times faster than reactions with 1,2,4,5-tetrazines. Additionally, we showed that the reaction of the cyclopropene-quinone pair can be activated by two orthogonal mechanisms: caging group removal on the cyclopropene and oxidation/reduction of the quinone. Finally, we demonstrated that this caged cyclopropene-quinone can be used as an imaging tool to label the membranes of fixed, cultured cells.","PeriodicalId":140,"journal":{"name":"ChemBioChem","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142054326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selective Dissolution of Calcium Pyrophosphate Dihydrate Crystals Using a Pyrophosphate Specific Receptor. 使用焦磷酸特异性受体选择性溶解二水焦磷酸钙晶体

IF 2.6 4区生物学

ChemBioChem Pub Date : 2024-11-04 Epub Date: 2024-09-09 DOI: 10.1002/cbic.202400319

Zachary H Paine, Mayank Sharma, Simon H Friedman

{"title":"Selective Dissolution of Calcium Pyrophosphate Dihydrate Crystals Using a Pyrophosphate Specific Receptor.","authors":"Zachary H Paine, Mayank Sharma, Simon H Friedman","doi":"10.1002/cbic.202400319","DOIUrl":"10.1002/cbic.202400319","url":null,"abstract":"Pseudo-gout is caused by the deposition of highly insoluble calcium pyrophosphate dihydrate (CPPD) crystals in the joints of sufferers. This leads to inflammation and ultimately joint damage. The insolubility of CPPD is driven by the strong attraction of di-cationic calcium ions with tetra-anionic pyrophosphate ions. One of the challenges of dissolving CPPD is that a related mineral, hydroxy apatite (HA) is present in larger amounts in the form of bone and also contains strongly interacting calcium and phosphate ions. Our aim in this work was to selectively dissolve CPPD in preference to HA. To accomplish this, we used a known receptor for pyrophosphate that contains two complexed zinc ions that are ideally spaced to interact with the tetra-anion of pyrophosphate. We hypothesized that such a molecule could act as a preorganized tetra-cation that would be able to outcompete the two calcium ions present in the crystal lattice of CPPD. We demonstrate both visually and through analysis of released phosphorous that this molecule is able to preferentially dissolve CPPD over the closely related HA and thus can form the basis for a possible approach for the treatment of pseudo-gout.","PeriodicalId":140,"journal":{"name":"ChemBioChem","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142152685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemoenzymatic Cyclization by Vanadium Chloroperoxidase for Synthesis of 4-Hydroxyisochroman-1-ones. 利用氯过氧化钒酶的化学合成环化作用合成 4-羟基异苯并二氢吡喃-1-酮。

IF 2.6 4区生物学

ChemBioChem Pub Date : 2024-11-03 DOI: 10.1002/cbic.202400697

Chisanu Krongyut, Nittaya Wiriya, Worakrit Saiyasombat, Kantapat Chansaenpak, Sineenat Sripattanakul, Anyanee Kamkaew, Rung-Yi Lai

引用次数: 0

Distinct Effects of SARS-CoV-2 Protein Segments on Structural Stability, Amyloidogenic Potential, and α-Synuclein Aggregation. SARS-CoV-2 蛋白段对结构稳定性、淀粉样蛋白生成潜能和 α-突触核蛋白聚集的不同影响

IF 2.6 4区生物学

ChemBioChem Pub Date : 2024-10-31 DOI: 10.1002/cbic.202400598

Vince St Dollente Mesias, Jianing Zhang, Hongni Zhu, Xin Dai, Jixi Li, Jinqing Huang

{"title":"Distinct Effects of SARS-CoV-2 Protein Segments on Structural Stability, Amyloidogenic Potential, and α-Synuclein Aggregation.","authors":"Vince St Dollente Mesias, Jianing Zhang, Hongni Zhu, Xin Dai, Jixi Li, Jinqing Huang","doi":"10.1002/cbic.202400598","DOIUrl":"10.1002/cbic.202400598","url":null,"abstract":"Amyloidosis is characterized by the abnormal accumulation of misfolded proteins, called amyloid fibrils, leading to diverse clinical manifestations. Recent studies on the amyloidogenesis of SARS-CoV‑2 protein segments have raised concerns on their potential link to post-infection neurodegeneration, however, the mechanisms remain unclear. Herein, we investigated the structure, stability, and amyloidogenic propensity of a nine-residue segment (SK9) of the SARS-CoV-2 envelope protein and their impact on neuronal protein α-synuclein (αSyn) aggregation. Specifically, the amino acid sequence of the SK9 wildtype has been modified from a basic and positively charged peptide (SFYVYSRVK), to a nearly neutral and more hydrophobic peptide (SAAVASAVK, labelled as SK9 var1), and to an acidic and positively charged peptide (SFYVYSRVK, labelled as SK9 var2). Our findings reveal that the SK9 wildtype exhibited a pronounced amyloidogenic propensity due to its disordered and unstable nature, while the SK9 variants possessed more ordered and stable structures preventing the amyloid formation. Significantly, the SK9 wildtype demonstrated distinct effect on αSyn aggregation kinetics and aggregate morphology to facilitate the formation of αSyn aggregates with enhanced resistance against enzymatic degradation. This study highlights the potential of modifying short peptide sequences to fine-tune their properties, providing insights into understanding and regulating viral-induced amyloid aggregations.","PeriodicalId":140,"journal":{"name":"ChemBioChem","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142556509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0