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A Selenylation-Isocyanation-Amine Addition Strategy Targeting Prenylated Derivatives to Disrupt Oncogenic Rat Sarcoma Level. 硒化-异氰化-胺添加策略靶向戊烯基化衍生物破坏癌变大鼠肉瘤水平。
IF 2.8 4区 生物学
ChemBioChem Pub Date : 2025-10-07 DOI: 10.1002/cbic.202500393
Xiaoqian Chen, Minxin Zhou, Yuyang Guo, Rui Wang
{"title":"A Selenylation-Isocyanation-Amine Addition Strategy Targeting Prenylated Derivatives to Disrupt Oncogenic Rat Sarcoma Level.","authors":"Xiaoqian Chen, Minxin Zhou, Yuyang Guo, Rui Wang","doi":"10.1002/cbic.202500393","DOIUrl":"https://doi.org/10.1002/cbic.202500393","url":null,"abstract":"<p><p>In recent years, significant strides have been made in protein prenylation research, a critical post-translational modification essential for modulating cellular signaling. Central to this advancement is the selenylation-isocyanation-amine Addition strategy, which employs amine-functionalized fluorescent or biotin-tagged probes to selectively label or isolate prenylated molecules. Herein, Rat Sarcoma (RAS) protein regulation in HCT116 cell lines through the development of a novel prenylation labeling method is investigated. This approach provides insights into the functional dynamics of prenylated proteins and enables targeted manipulation of these molecules. While this work primarily establishes a methodological advance, it lays the foundation for future studies to elucidate RAS-related oncogenic signaling pathways and explore therapeutic strategies targeting prenylation-dependent processes.</p>","PeriodicalId":140,"journal":{"name":"ChemBioChem","volume":" ","pages":"e202500393"},"PeriodicalIF":2.8,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145237465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondria-Targeted Delivery of siRNA by Amphiphilic Nanovectors Self-Assembled from a Cationic [4]Helicene-Squalene Ester. 由阳离子b[4]螺旋烯-角鲨烯酯自组装的两亲性纳米载体在线粒体靶向递送siRNA。
IF 2.8 4区 生物学
ChemBioChem Pub Date : 2025-10-07 DOI: 10.1002/cbic.202500537
Lamiaa M A Ali, Dan-Dan Su, Rebecca Mucci, Kévin Martin, Mihail Barboiu, Jérôme Lacour, Nadir Bettache, Sébastien Ulrich
{"title":"Mitochondria-Targeted Delivery of siRNA by Amphiphilic Nanovectors Self-Assembled from a Cationic [4]Helicene-Squalene Ester.","authors":"Lamiaa M A Ali, Dan-Dan Su, Rebecca Mucci, Kévin Martin, Mihail Barboiu, Jérôme Lacour, Nadir Bettache, Sébastien Ulrich","doi":"10.1002/cbic.202500537","DOIUrl":"https://doi.org/10.1002/cbic.202500537","url":null,"abstract":"<p><p>The active delivery of therapeutic nucleic acids with subcellular precision is an open challenge. Herein, a small conjugate molecule, combining a cationic [4]helicene moiety with a lipophilic squalene tail, yields amphiphilic nanoassemblies capable of effectively complexing siRNA within the mitochondria. A proof-of-concept in HCT 116 colorectal cancer cells was evidenced by Western blot for the delivery of siRNA silencing the protein expression of the mitochondria-encoded cytochrome c oxidase subunit 1 gene.</p>","PeriodicalId":140,"journal":{"name":"ChemBioChem","volume":" ","pages":"e202500537"},"PeriodicalIF":2.8,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145237470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functionalizing Injectable Hydrogels with Cobalt-Based Metallacarboranes for Targeted Delivery in Triple-Negative Breast Cancer. 钴基金属硼烷功能化可注射水凝胶用于三阴性乳腺癌的靶向递送。
IF 2.8 4区 生物学
ChemBioChem Pub Date : 2025-10-07 DOI: 10.1002/cbic.202500589
Neville Murphy, Roberto González-Gómez, Nivethitha Ashok, Enda O'Connell, Howard Fearnhead, William J Tipping, Karen Faulds, Wenming Tong, Abhay Pandit, Róisín M Dwyer, Duncan Graham, Pau Farràs
{"title":"Functionalizing Injectable Hydrogels with Cobalt-Based Metallacarboranes for Targeted Delivery in Triple-Negative Breast Cancer.","authors":"Neville Murphy, Roberto González-Gómez, Nivethitha Ashok, Enda O'Connell, Howard Fearnhead, William J Tipping, Karen Faulds, Wenming Tong, Abhay Pandit, Róisín M Dwyer, Duncan Graham, Pau Farràs","doi":"10.1002/cbic.202500589","DOIUrl":"https://doi.org/10.1002/cbic.202500589","url":null,"abstract":"<p><p>Cobalt-based metallacarboranes have emerged as potential candidates for cancer treatment owing to their unique structural properties. In this study, a biocompatible delivery platform is developed by noncovalently incorporating cobalt metallacarborane (CoSAN) into hyaluronic acid (HA) functionalized with lysine (Lys). HA-Lys 2 enables the electrostatic interaction of CoSAN while retaining its cytotoxic activity, as confirmed by cellular assays using MDA-MB-231 triple-negative breast cancer cells. Elemental mapping via energy-dispersive X-ray spectroscopy (EDX) confirms the successful and homogeneous incorporation of CoSAN to lead HA-Lys-CoSAN 3, and the composite is further characterized using diffusion-ordered nuclear magnetic resonance (NMR) spectroscopy (DOSY). Stimulated Raman scattering (SRS) microscopy data demonstrate comparable cellular uptake in MDA-MB-231 cells of free and HA-loaded CoSAN. Additionally, release studies under physiologically relevant conditions show a sustained release profile over 24 h with pH dependency to mimic normal and tumor microenvironments. The present study describes a viable method for integrating metallacarboranes into a polymeric drug delivery system without compromising their anticancer properties, thereby advancing their potential for future therapeutic use.</p>","PeriodicalId":140,"journal":{"name":"ChemBioChem","volume":" ","pages":"e202500589"},"PeriodicalIF":2.8,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145237479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ThiF-Like Enzyme Chemistry in Primary and Secondary Metabolism. thif类酶化学在初级和次级代谢中的作用。
IF 2.8 4区 生物学
ChemBioChem Pub Date : 2025-10-06 DOI: 10.1002/cbic.202500460
Keelie S Butler, Anshul Rajput, Jonathan R Chekan
{"title":"ThiF-Like Enzyme Chemistry in Primary and Secondary Metabolism.","authors":"Keelie S Butler, Anshul Rajput, Jonathan R Chekan","doi":"10.1002/cbic.202500460","DOIUrl":"https://doi.org/10.1002/cbic.202500460","url":null,"abstract":"<p><p>ThiF-like proteins are members of the widespread E1-like enzyme superfamily. The eponymous ThiF enzyme was first described in thiamin biosynthesis as part of Escherichia coli's primary metabolism, and homologous proteins have been subsequently discovered in secondary metabolism. These ThiF-like enzymes are united in their defining ability to perform nucleotidylation of a carboxyl group to generate an activated, electrophilic intermediate, a feature it shares with the structurally related ubiquitin-activating enzymes. From here, an array of different nucleophiles are used across distinct biosynthetic pathways to yield diverse structural scaffolds. In this review, we discuss various ThiF-like enzymes that perform nucleotidylation to facilitate a diverse array of interesting and rare chemistry on different types of substrates, as well as showcase some of the shared structural features.</p>","PeriodicalId":140,"journal":{"name":"ChemBioChem","volume":" ","pages":"e202500460"},"PeriodicalIF":2.8,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145230980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Front Cover: Recent Advances in the Photochemical Biology of Serotonin (ChemBioChem 19/2025) 封面：5 -羟色胺光化学生物学研究进展（ChemBioChem 19/2025）
IF 2.8 4区 生物学
ChemBioChem Pub Date : 2025-10-06 DOI: 10.1002/cbic.70062
Claire E. Nieder, Michael A. Kienzler
{"title":"Front Cover: Recent Advances in the Photochemical Biology of Serotonin (ChemBioChem 19/2025)","authors":"Claire E. Nieder,&nbsp;Michael A. Kienzler","doi":"10.1002/cbic.70062","DOIUrl":"https://doi.org/10.1002/cbic.70062","url":null,"abstract":"<p>The Front Cover depicts a cell surface with a human serotonin transporter protein, illuminated by the spectrum of visible light and surrounded by several photochemical tools. The molecular structures are, from left to right, azo-5HT1, azo-escitalopram, RuBi-5-HT, and SERTlight. Each represents a different group of compounds discussed in the Review Artilce by Michael A. Kienzler and co-workers (DOI: 10.1002/cbic.202500276). The other proteins on the cell surface are various human serotonin receptors.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":140,"journal":{"name":"ChemBioChem","volume":"26 19","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/cbic.70062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reaction Engineering of In Vitro Natural Product Biosynthesis: Challenges and Strategies. 体外天然产物生物合成的反应工程：挑战与策略。
IF 2.8 4区 生物学
ChemBioChem Pub Date : 2025-10-06 DOI: 10.1002/cbic.202500571
Elsa Sánchez-García, Stephan Lütz, Markus Nett
{"title":"Reaction Engineering of In Vitro Natural Product Biosynthesis: Challenges and Strategies.","authors":"Elsa Sánchez-García, Stephan Lütz, Markus Nett","doi":"10.1002/cbic.202500571","DOIUrl":"https://doi.org/10.1002/cbic.202500571","url":null,"abstract":"<p><p>Natural products are widely used as pharmaceuticals and agrochemicals, or as active ingredients in food and cosmetics. Their biosynthesis typically involves a series of enzyme-controlled reactions in dedicated liquid environments. The reconstruction of these multistep transformations under in vitro conditions bears significant potential for technical utilization. However, the concurrent operation of multiple enzymes in a single reaction flask or reactor is often associated with major challenges. Herein, the difficulties in reaching high substrate conversion and product yields with in vitro enzyme cascades are summarized. Furthermore, both established and emerging concepts for improving their performance are discussed.</p>","PeriodicalId":140,"journal":{"name":"ChemBioChem","volume":" ","pages":"e202500571"},"PeriodicalIF":2.8,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145230955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glycosaminoglycans as Polyelectrolytes: Charge, Interactions, and Applications. 作为聚电解质的糖胺聚糖：电荷、相互作用和应用。
IF 2.8 4区 生物学
ChemBioChem Pub Date : 2025-10-06 DOI: 10.1002/cbic.202500418
Gergo Peter Szekeres, Eunjin Moon, Johanna K Elter, Bryce Roper, Jayachandran Narayanan Nair Kizhakkedathu, Matthias Ballauff, Rainer Haag, Kevin Pagel
{"title":"Glycosaminoglycans as Polyelectrolytes: Charge, Interactions, and Applications.","authors":"Gergo Peter Szekeres, Eunjin Moon, Johanna K Elter, Bryce Roper, Jayachandran Narayanan Nair Kizhakkedathu, Matthias Ballauff, Rainer Haag, Kevin Pagel","doi":"10.1002/cbic.202500418","DOIUrl":"https://doi.org/10.1002/cbic.202500418","url":null,"abstract":"<p><p>Glycosaminoglycans (GAGs) are linear, negatively charged biopolymers that modulate complex biological processes, such as blood coagulation, immune regulation, or viral entry. Their sulfation pattern and chain length govern how strongly they bind to other physiologically relevant species. Most of these interactions rely on electrostatic forces facilitated by the strong polyanionic properties of GAGs; therefore, considering these from a polyelectrolyte vantage point can help understand how such charge-based, often transient interactions contribute to physiological and pathological processes. While the different GAG classes share key electrostatic properties, they exhibit unique structural features that shape their function. Here, it is highlighted on how modern separation and analytical tools exploit the polyanionic character of GAGs to dissect subtle structural details. For these, the fundamental description of their charge-charge interactions is crucial. With this knowledge, modified GAGs, synthetic GAG mimetics, or GAG-binding molecules can be designed that replicate or refine their key properties and show promise for therapeutic and biomedical applications. Altogether, recognizing the importance of GAGs as polyelectrolytes provides vital knowledge on how their charge distribution mediates crucial biomolecular interactions in health and disease, and thus it helps complete our knowledge on fundamentally important biopolymers.</p>","PeriodicalId":140,"journal":{"name":"ChemBioChem","volume":" ","pages":"e202500418"},"PeriodicalIF":2.8,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145230947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Molecule to Meaning: Click and Bioorthogonal Chemical Reporters for Plant Systems, Biological Imaging, and Artistic Expression. 从分子到意义：点击和生物正交化学报告植物系统，生物成像，和艺术表达。
IF 2.8 4区 生物学
ChemBioChem Pub Date : 2025-10-03 DOI: 10.1002/cbic.202500518
Marie Hinnebo, Clémence Simon, Adèle Tilouine, Corentin Spriet, Christophe Biot
{"title":"From Molecule to Meaning: Click and Bioorthogonal Chemical Reporters for Plant Systems, Biological Imaging, and Artistic Expression.","authors":"Marie Hinnebo, Clémence Simon, Adèle Tilouine, Corentin Spriet, Christophe Biot","doi":"10.1002/cbic.202500518","DOIUrl":"https://doi.org/10.1002/cbic.202500518","url":null,"abstract":"<p><p>Chemical biology has reshaped the ability to investigate complex biological systems at the molecular level. In this context, chemical reporters have become important tools for labeling and tracking biomolecules in living systems with spatial and temporal precision. In plant biology, they provide an alternative to genetic approaches and allow the study of dynamic processes in species or organs that are not easily accessible. Through the use of click and bioorthogonal chemistry, small-molecule probes can be metabolically incorporated into specific molecular scaffolds such as sugars, monolignols, amino acids, and lipids. These probes make it possible to follow events like glycosylation, lignification, lipid turnover, or protein synthesis in living plant tissues. This review presents an overview of current chemical reporter strategies, from molecular design and synthetic considerations to their application in plant imaging. Herein, how these tools have contributed to the development of plant chemical biology by enabling precise and modular investigations of plant structure and metabolism is described. Herein, it is also examined how chemical reporters have entered interdisciplinary contexts, including collaborations between science and the arts. By converting molecular-level information into visual and sensory formats, these approaches open new perspectives for research, education, and communication across scientific and creative disciplines.</p>","PeriodicalId":140,"journal":{"name":"ChemBioChem","volume":" ","pages":"e202500518"},"PeriodicalIF":2.8,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances and Challenges in Bioprocess Optimization for the Synthesis of Sugar Nucleotides. 糖核苷酸合成生物工艺优化研究进展与挑战。
IF 2.8 4区 生物学
ChemBioChem Pub Date : 2025-10-03 DOI: 10.1002/cbic.202500434
Tom L Roberts, Sebastian C Cosgrove, Gavin J Miller
{"title":"Advances and Challenges in Bioprocess Optimization for the Synthesis of Sugar Nucleotides.","authors":"Tom L Roberts, Sebastian C Cosgrove, Gavin J Miller","doi":"10.1002/cbic.202500434","DOIUrl":"https://doi.org/10.1002/cbic.202500434","url":null,"abstract":"<p><p>Sugar nucleotides represent the cornerstone building blocks for glycan biosynthesis. While methods to access these crucial biomolecules using traditional batch synthetic chemistry and enzymatic approaches have blossomed, uptake using flow-based synthesis is burgeoning. This perspective analyzes recent advances concerning enzyme immobilization and continuous flow biocatalysis for sugar nucleotide production and usage. Evaluation of related technologies is also discussed, highlighting new enzyme immobilization approaches, novel reactor design, and improved downstream processing as areas that must evolve to enable wider, scalable access to sugar nucleotides as commodity chemicals.</p>","PeriodicalId":140,"journal":{"name":"ChemBioChem","volume":" ","pages":"e202500434"},"PeriodicalIF":2.8,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Advances on Dehydroalanine-Specific Modification and Diversification of Peptides and Proteins. 肽和蛋白的脱氢丙氨酸特异性修饰和多样化研究进展。
IF 2.8 4区 生物学
ChemBioChem Pub Date : 2025-10-01 DOI: 10.1002/cbic.202500349
Changjun Yu, Guangjun Bao, Wangsheng Sun
{"title":"Recent Advances on Dehydroalanine-Specific Modification and Diversification of Peptides and Proteins.","authors":"Changjun Yu, Guangjun Bao, Wangsheng Sun","doi":"10.1002/cbic.202500349","DOIUrl":"10.1002/cbic.202500349","url":null,"abstract":"<p><p>In recent years, chemical modification techniques based on dehydroalanine (Dha) have become a prominent area in the functionalization of peptides and proteins due to their high efficiency and site selectivity. This article reviews the recent advancements in the modification of Dha-containing peptides and proteins. Focusing on the chemical properties of Dha, the advantages of nucleophilic addition reactions, free radical chemistry, metal-catalyzed cross-coupling reactions, and cycloaddition reactions in peptide and protein modification are discussed, as well as their applicability in the development of novel biocompatible methods. Additionally, the article explores the current limitations of these techniques and highlights future challenges that need to be addressed.</p>","PeriodicalId":140,"journal":{"name":"ChemBioChem","volume":" ","pages":"e202500349"},"PeriodicalIF":2.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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