International Journal of Gynecological Cancer最新文献

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Clinician perceptions of asynchronous care for patients with ovarian cancer on PARP inhibitor therapy.
IF 4.1 2区 医学
International Journal of Gynecological Cancer Pub Date : 2025-03-21 DOI: 10.1016/j.ijgc.2025.101788
Melissa Kozak, Ainhoa Madariaga, Yuliya Gavrylyuk, Genevieve Bouchard-Fortier, Valerie Bowering, Nazlin Jivraj, Tran Truong, Mike Lovas, Kelly Lane, Soyoun R Kim, Adam Badzynski, Jennifer Catton, Stephanie Lheureux, Alejandro Berlin
{"title":"Clinician perceptions of asynchronous care for patients with ovarian cancer on PARP inhibitor therapy.","authors":"Melissa Kozak, Ainhoa Madariaga, Yuliya Gavrylyuk, Genevieve Bouchard-Fortier, Valerie Bowering, Nazlin Jivraj, Tran Truong, Mike Lovas, Kelly Lane, Soyoun R Kim, Adam Badzynski, Jennifer Catton, Stephanie Lheureux, Alejandro Berlin","doi":"10.1016/j.ijgc.2025.101788","DOIUrl":"https://doi.org/10.1016/j.ijgc.2025.101788","url":null,"abstract":"<p><p>Asynchronous care is an alternative model of care involving information transmission without a simultaneous interaction between people. This study aimed to understand clinician perspectives about providing asynchronous care to patients with ovarian cancer who are clinically stable and receiving poly(adenosine diphosphate-ribose) polymerase inhibitor (PARPi) maintenance therapy at a large academic teaching hospital. The Theoretical Domains Framework (TDF) was used to undertake this study. Interviews were conducted with oncologists, physician assistants, and nurses who actively manage this patient population. Data were analyzed according to TDF domains to generate themes and understand supports, barriers, and buy-in related to this model of care. Overall, 73% of the 15 clinicians (50% of the oncologists) participating in this study were willing to provide asynchronous care to patients on PARPi who were clinically stable. Several themes emerged representing considerations for moving forward with this model of care, including selecting the ideal patients, streamlined access to information, safe and effective escalations, perceived acceptability of the asynchronous model by clinicians, reimbursement, and an opportunity and willingness to innovate. Participants recognized the potential benefits of an asynchronous care model for patients on PARPi therapy who are clinically stable and the opportunity to innovate while optimizing the use of limited clinic resources. Continued work toward discovery and implementation of an asynchronous care model should account for findings uncovered by application of the TDF.</p>","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":"35 5","pages":"101788"},"PeriodicalIF":4.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ISUOG/ESGO Consensus Statement on ultrasound-guided biopsy in gynecological oncology.
IF 4.1 2区 医学
International Journal of Gynecological Cancer Pub Date : 2025-03-21 DOI: 10.1016/j.ijgc.2025.101732
D Fischerova, F Planchamp, J L Alcázar, P Dundr, E Epstein, A Felix, F Frühauf, G Garganese, I Salvesen Haldorsen, D Jurkovic, R Kocian, D Lengyel, F Mascilini, A Stepanyan, M Stukan, S Timmerman, T Vanassche, Z Yuan Ng, U Scovazzi
{"title":"ISUOG/ESGO Consensus Statement on ultrasound-guided biopsy in gynecological oncology.","authors":"D Fischerova, F Planchamp, J L Alcázar, P Dundr, E Epstein, A Felix, F Frühauf, G Garganese, I Salvesen Haldorsen, D Jurkovic, R Kocian, D Lengyel, F Mascilini, A Stepanyan, M Stukan, S Timmerman, T Vanassche, Z Yuan Ng, U Scovazzi","doi":"10.1016/j.ijgc.2025.101732","DOIUrl":"https://doi.org/10.1016/j.ijgc.2025.101732","url":null,"abstract":"<p><p>The International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) with the European Society of Gynaecological Oncology (ESGO) jointly developed clinically relevant and evidence-based statements on performing ultrasound-guided biopsies in gynecological oncology. The objective of this Consensus Statement is to assist clinicians, including gynecological sonographers, gynecological oncologists and radiologists, to achieve the best standards of practice in ultrasound-guided biopsy procedures. ISUOG/ESGO nominated a multidisciplinary international group of 16 experts who have demonstrated leadership in the use of ultrasound-guided biopsy in the clinical management of patients with gynecological cancer. In addition, two early-career gynecological fellows were nominated to participate from the European Network of Young Gynae Oncologists (ENYGO) within ESGO and from ISUOG. The group also included a patient representative from the European Network of Gynaecological Cancer Advocacy Groups. The document is divided into six sections: (1) general recommendations; (2) image-guided biopsy (imaging guidance, sampling methods); (3) indications and contraindications; (4) technique; (5) reporting; and (6) training and quality assurance. To ensure that the statements are evidence-based, the current literature was reviewed and critically appraised. Preliminary statements were drafted based on this review of the literature. During a conference call, the whole group discussed each preliminary statement, and a first round of voting was carried out. The group achieved consensus on all 46 preliminary statements without the need for revision. These ISUOG/ESGO statements on ultrasound-guided biopsy in gynecological oncology, together with a summary of the evidence supporting each statement, are presented herein. This Consensus Statement is supplemented by detailed narrated videoclips presenting different approaches and indications for ultrasound-guided biopsy, a patient leaflet, and an extended version which includes a detailed review of the evidence.</p>","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":" ","pages":"101732"},"PeriodicalIF":4.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A promising partnership? Exploring cyclin-dependent kinase 4/6 inhibition and hormonal therapy in endometrial cancer.
IF 4.1 2区 医学
International Journal of Gynecological Cancer Pub Date : 2025-03-14 DOI: 10.1016/j.ijgc.2025.101769
Mariana Carvalho Gouveia, Marina Acevedo Zarzar de Melo, Renata Colombo Bonadio, Mariana Scaranti
{"title":"A promising partnership? Exploring cyclin-dependent kinase 4/6 inhibition and hormonal therapy in endometrial cancer.","authors":"Mariana Carvalho Gouveia, Marina Acevedo Zarzar de Melo, Renata Colombo Bonadio, Mariana Scaranti","doi":"10.1016/j.ijgc.2025.101769","DOIUrl":"https://doi.org/10.1016/j.ijgc.2025.101769","url":null,"abstract":"","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":"35 5","pages":"101769"},"PeriodicalIF":4.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neoadjuvant chemotherapy in stage IB2 to IB3 cervical cancer: because we can or because we must? IB2 至 IB3 期宫颈癌的新辅助化疗:因为我们可以还是因为我们必须?
IF 4.1 2区 医学
International Journal of Gynecological Cancer Pub Date : 2025-03-14 DOI: 10.1016/j.ijgc.2025.101770
Philippe Morice, Sebastien Gouy, Marie Plante, Nadeem Abu-Rustum
{"title":"Neoadjuvant chemotherapy in stage IB2 to IB3 cervical cancer: because we can or because we must?","authors":"Philippe Morice, Sebastien Gouy, Marie Plante, Nadeem Abu-Rustum","doi":"10.1016/j.ijgc.2025.101770","DOIUrl":"https://doi.org/10.1016/j.ijgc.2025.101770","url":null,"abstract":"","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":" ","pages":"101770"},"PeriodicalIF":4.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sentinel SENECA risk factors for unsuccessful bi-lateral sentinel lymph node mapping in endometrial cancer.
IF 4.1 2区 医学
International Journal of Gynecological Cancer Pub Date : 2025-03-14 DOI: 10.1016/j.ijgc.2025.101771
Félix Boria, Enrique Chacón, R Rajagopalan Iyer, Francesco Fanfani, Francesca Falcone, Petra Bretová, Ana Luzarraga Aznar, Robert Fruscio, Marcin Jedryka, Richard Tóth, Artem Stepanyan, Gurkan Kiran, Cecilia Darin, Agnieszka Rychlik, Ester Miralpeix, Meriem Koual, Roberto Berretta, Natalia Anna Palasz, Duska Beric, Dimitrios Tsolakidis, Soledad Fidalgo, Richard Schwameis, Somashekhar Sp, Ibrahim Yalcin, Radovan Pilka, Cagatay Taskiran, Despoina Myoteri, Estibaliz Iza Rodriguez, Dariusz G Wydra, Silvia Catot, Mathias Fehr, Frederic Goffin, Maria Ercilia Ibarra, Stamatios Petousis, Enrique Moratalla Bartolomé, Mareike Bommert, Alfonso Quesada, Shamistan Aliyev, José Ángel Mínguez, Luis Chiva
{"title":"Sentinel SENECA risk factors for unsuccessful bi-lateral sentinel lymph node mapping in endometrial cancer.","authors":"Félix Boria, Enrique Chacón, R Rajagopalan Iyer, Francesco Fanfani, Francesca Falcone, Petra Bretová, Ana Luzarraga Aznar, Robert Fruscio, Marcin Jedryka, Richard Tóth, Artem Stepanyan, Gurkan Kiran, Cecilia Darin, Agnieszka Rychlik, Ester Miralpeix, Meriem Koual, Roberto Berretta, Natalia Anna Palasz, Duska Beric, Dimitrios Tsolakidis, Soledad Fidalgo, Richard Schwameis, Somashekhar Sp, Ibrahim Yalcin, Radovan Pilka, Cagatay Taskiran, Despoina Myoteri, Estibaliz Iza Rodriguez, Dariusz G Wydra, Silvia Catot, Mathias Fehr, Frederic Goffin, Maria Ercilia Ibarra, Stamatios Petousis, Enrique Moratalla Bartolomé, Mareike Bommert, Alfonso Quesada, Shamistan Aliyev, José Ángel Mínguez, Luis Chiva","doi":"10.1016/j.ijgc.2025.101771","DOIUrl":"https://doi.org/10.1016/j.ijgc.2025.101771","url":null,"abstract":"<p><strong>Objective: </strong>Our study aims to assess the risk factors associated with bi-lateral sentinel lymph node (SLN) mapping failure in endometrial cancer.</p><p><strong>Methods: </strong>The SENECA study was a retrospective multi-center international observational study that reviewed data from 2139 women with clinical stage I-to-II endometrial cancer across 64 centers in 17 countries. Between January 2021 and December 2022, patients underwent surgical treatment with SLN assessment, following the guidelines of the European Society of Gynaecological Oncology. Risk factors associated with the absence of bi-lateral mapping were analyzed using χ<sup>2</sup> and t tests. All factors that showed statistical associations were included in a multi-variate regression analysis.</p><p><strong>Results: </strong>Among the 2139 patients, the bi-lateral lymph node detection rate was 82.7%, whereas the unilateral detection rate was 97.3%. In multi-variate analysis, 5 risk factors remained statistically associated with unsuccessful bi-lateral lymph node mapping: high-grade histology (OR 1.35, 95% CI 1.02 to 1.79, p = .03), myometrial invasion >50% (OR 1.37, 95% CI 1.07 to 1.75, p = .012), low-volume surgeon <20 cases/year (OR 2.11, 95% CI 1.55 to 2.89, p < .01), open surgical approach (OR 1.72, 95% CI 1.06 to 2.78 , p = .03), and non-indocyanine green tracer (OR 4.59, 95% CI 2.64 to 7.99, p < .01). The addition of bi-lateral pelvic lymphadenectomy and/or paraaortic lymphadenectomy to SLN biopsy caused an increased rate of intra-operative complications (2% vs 8.4%, p < .01) and all-grade post-operative complications (4.1% vs 11.2%, p < .01).</p><p><strong>Conclusions: </strong>Our study identifies 5 risk factors associated with unsuccessful lymph node mapping in endometrial cancer. Efforts should be made to perform this technique with indocyanine green, through minimally invasive surgery, and performed or supervised by an experienced surgeon with ≥20 endometrial cancer cases per year.</p>","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":" ","pages":"101771"},"PeriodicalIF":4.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes of low-risk endometrial cancer with isolated tumor cells in the sentinel lymph nodes: a prospective, multi-center, single-arm, observational study (ENDO-ITC study).
IF 4.1 2区 医学
International Journal of Gynecological Cancer Pub Date : 2025-03-07 DOI: 10.1016/j.ijgc.2025.101764
Luigi A De Vitis, Giorgio Bogani, Francesco Raspagliesi, Octavio Arencibia Sanchez, Beatriz Navarro, Francesco Multinu, Vanna Zanagnolo, Glauco Baiocchi, Louise De Brot, Francesco Fanfani, Ilaria Capasso, Sabrina Piedimonte, Lara DeGuerke, Alessandro Buda, Jessica Mauro, Manuela Alessio, Federica Filipello, Mario Beiner, Yfat Kadan, Andrea Papadia, Giuseppe Vizzielli, Stefano Restaino, Tommaso Grassi, Fabio Landoni, Tommaso Bianchi, Christoph Grimm, Stephan Polterauer, Giulio Ricotta, Alejandra Martinez, Paul Buderath, Rainer Kimmig, Vito Chiantera, Behrouz Zand, Ignacio Zapardiel, Alicia Hernandez, Stephanie Gill, Allan Covens, Christian Dagher, Tommaso Meschini, Giuseppe Cucinella, Gabriella Schivardi, Tommaso Occhiali, Antonio Lembo, Emilia Palmieri, Maryam Shahi, Angela J Fought, Michaela E McGree, Vera J Suman, Nadeem R Abu-Rustum, Pedro T Ramirez, Andrea Mariani, Gretchen E Glaser
{"title":"Outcomes of low-risk endometrial cancer with isolated tumor cells in the sentinel lymph nodes: a prospective, multi-center, single-arm, observational study (ENDO-ITC study).","authors":"Luigi A De Vitis, Giorgio Bogani, Francesco Raspagliesi, Octavio Arencibia Sanchez, Beatriz Navarro, Francesco Multinu, Vanna Zanagnolo, Glauco Baiocchi, Louise De Brot, Francesco Fanfani, Ilaria Capasso, Sabrina Piedimonte, Lara DeGuerke, Alessandro Buda, Jessica Mauro, Manuela Alessio, Federica Filipello, Mario Beiner, Yfat Kadan, Andrea Papadia, Giuseppe Vizzielli, Stefano Restaino, Tommaso Grassi, Fabio Landoni, Tommaso Bianchi, Christoph Grimm, Stephan Polterauer, Giulio Ricotta, Alejandra Martinez, Paul Buderath, Rainer Kimmig, Vito Chiantera, Behrouz Zand, Ignacio Zapardiel, Alicia Hernandez, Stephanie Gill, Allan Covens, Christian Dagher, Tommaso Meschini, Giuseppe Cucinella, Gabriella Schivardi, Tommaso Occhiali, Antonio Lembo, Emilia Palmieri, Maryam Shahi, Angela J Fought, Michaela E McGree, Vera J Suman, Nadeem R Abu-Rustum, Pedro T Ramirez, Andrea Mariani, Gretchen E Glaser","doi":"10.1016/j.ijgc.2025.101764","DOIUrl":"https://doi.org/10.1016/j.ijgc.2025.101764","url":null,"abstract":"<p><strong>Background: </strong>It is unclear whether isolated tumor cells (ITCs) in sentinel lymph nodes (SLNs) adversely affect prognosis, especially in low-risk endometrial cancer. In a retrospective study, we showed a worse recurrence-free survival for low-risk endometrial cancer with ITCs than the node-negative group.</p><p><strong>Primary objective: </strong>Our aim is to evaluate whether the likelihood of disease recurrence differs between a prospective cohort of patients with low-risk endometrial cancer with ITCs and an historical cohort with negative SLNs.</p><p><strong>Study hypothesis: </strong>We hypothesize that patients with low-risk endometrial cancer and ITCs will have a worse recurrence-free survival than patients who are node-negative.</p><p><strong>Trial design: </strong>This is a prospective, multi-center, single-arm observational study. Consecutive patients with low-risk endometrial cancer with ITCs in the SLNs will be accrued. Observation only will be suggested after surgery.</p><p><strong>Major inclusion/exclusion criteria: </strong>We will include patients with endometrial cancer undergoing pelvic SLN biopsy and ultra-staging with the following characteristics: endometrioid histology, grades 1 to 2, <50% myometrial invasion, without substantial/extensive lympho-vascular space invasion. ITCs in SLNs are defined as tumor cell aggregates ≤0.2 mm or <200 cells.</p><p><strong>Primary end point: </strong>The primary end point is recurrence-free survival, measured from the date of surgery to the date of recurrence, death, or last disease evaluation.</p><p><strong>Sample size: </strong>With a sample size of 132 women with low-risk endometrial cancer and ITCs, a 1-sided log-rank test achieves 85% power at a 0.05 significance level to detect an HR of 2.1. The expected number of events during the study is 17.3.</p><p><strong>Estimated dates for completing accrual and presenting results: </strong>The study duration will be 60 months: 24 for enrollment and 36 for follow-up. The results are expected in 2029.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov: NCT06689956.</p>","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":" ","pages":"101764"},"PeriodicalIF":4.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The unresolved dilemma of lymphovascular space invasion in endometrial cancer: keeping the debate open.
IF 4.1 2区 医学
International Journal of Gynecological Cancer Pub Date : 2025-03-07 DOI: 10.1016/j.ijgc.2025.101762
Luigi De Vitis, Emilia Palmieri, Andrea Mariani
{"title":"The unresolved dilemma of lymphovascular space invasion in endometrial cancer: keeping the debate open.","authors":"Luigi De Vitis, Emilia Palmieri, Andrea Mariani","doi":"10.1016/j.ijgc.2025.101762","DOIUrl":"https://doi.org/10.1016/j.ijgc.2025.101762","url":null,"abstract":"","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":" ","pages":"101762"},"PeriodicalIF":4.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correspondence on Laparoscopic bariatric surgery with hysterectomy for endometrial cancer to improve long-term outcomes: A review article by Goddard et al.
IF 4.1 2区 医学
International Journal of Gynecological Cancer Pub Date : 2025-03-07 DOI: 10.1016/j.ijgc.2025.101763
Francesco Mezzapesa, Pierandrea De Iaco, Anna Myriam Perrone
{"title":"Correspondence on Laparoscopic bariatric surgery with hysterectomy for endometrial cancer to improve long-term outcomes: A review article by Goddard et al.","authors":"Francesco Mezzapesa, Pierandrea De Iaco, Anna Myriam Perrone","doi":"10.1016/j.ijgc.2025.101763","DOIUrl":"https://doi.org/10.1016/j.ijgc.2025.101763","url":null,"abstract":"","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":" ","pages":"101763"},"PeriodicalIF":4.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HPV-associated and HPV-independent vulvar squamous cell carcinoma: is there an impact of resection margins on local recurrence?
IF 4.1 2区 医学
International Journal of Gynecological Cancer Pub Date : 2025-03-05 DOI: 10.1016/j.ijgc.2025.101757
Marilyn Boo, Lynn Sadler, Susan Bigby, Lois Eva
{"title":"HPV-associated and HPV-independent vulvar squamous cell carcinoma: is there an impact of resection margins on local recurrence?","authors":"Marilyn Boo, Lynn Sadler, Susan Bigby, Lois Eva","doi":"10.1016/j.ijgc.2025.101757","DOIUrl":"https://doi.org/10.1016/j.ijgc.2025.101757","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the impact of resection margins on the first local recurrence of vulvar squamous cell carcinoma, stratified by human papillomavirus (HPV) status: HPV-associated (HPV-A) and HPV-independent (HPV-I). It also investigated the association between precursor lesions of vulvar squamous cell carcinoma at the resection margins and the risk of first local vulvar squamous cell carcinoma recurrence.</p><p><strong>Methods: </strong>This was a retrospective single-center clinicopathological case note review of patients treated with primary surgery for vulvar squamous cell carcinoma between January 1990 and December 2020, with follow-up until February 2024. The impact of pathological margins on first local recurrence was assessed for HPV-A and HPV-I tumors separately in univariable and multi-variable survival analyses.</p><p><strong>Results: </strong>A total of 360 vulvar squamous cell carcinoma cases were identified. Local recurrences were reported in 12 of 166 (7.2%) HPV-A and 53 of 194 (27.3%) HPV-I tumors (p < .001). Pathological margins <8 mm were significantly associated with increased local recurrence in HPV-I vulvar squamous cell carcinoma, with both univariable (HR 2.34, 95% CI 1.33-4.10, p = .003) and multi-variable analysis (adjusted HR 2.06, 95% CI 1.14 to 3.71, p = .0017) confirming this association. No significant association was observed in HPV-A vulvar squamous cell carcinoma (HR 0.70, 95% CI 0.22 to 2.24, p = .55). The number of HPV-A recurrences precluded multi-variable analysis. After stratifying by HPV sub-type, there was no association between precursors at the margins and local recurrence.</p><p><strong>Conclusions: </strong>Local recurrences are more common in HPV-I than HPV-A vulvar squamous cell carcinoma. Surgical margins may not influence the risk of local recurrence in HPV-A vulvar squamous cell carcinoma. However, in HPV-I vulvar squamous cell carcinoma, narrow resection margins of <8 mm appear to increase the risk of local recurrence. Therefore, HPV status should be incorporated into management protocols to risk-stratify follow-up care.</p>","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":" ","pages":"101757"},"PeriodicalIF":4.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correspondence on "Effect of uterine manipulator on oncologic outcome in early-stage, low-grade endometrial cancer" by Ye et al.
IF 4.1 2区 医学
International Journal of Gynecological Cancer Pub Date : 2025-03-05 DOI: 10.1016/j.ijgc.2025.101761
Fazil Avci
{"title":"Correspondence on \"Effect of uterine manipulator on oncologic outcome in early-stage, low-grade endometrial cancer\" by Ye et al.","authors":"Fazil Avci","doi":"10.1016/j.ijgc.2025.101761","DOIUrl":"https://doi.org/10.1016/j.ijgc.2025.101761","url":null,"abstract":"","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":" ","pages":"101761"},"PeriodicalIF":4.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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