International Journal of Gynecological Cancer最新文献

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Dermatofibrosarcoma protuberans of the vulva. 外阴隆突性皮肤纤维肉瘤。
IF 4.1 2区 医学
International Journal of Gynecological Cancer Pub Date : 2025-06-01 Epub Date: 2025-02-05 DOI: 10.1016/j.ijgc.2025.101674
José Antonio Pérez-Álvarez, Félix Boria
{"title":"Dermatofibrosarcoma protuberans of the vulva.","authors":"José Antonio Pérez-Álvarez, Félix Boria","doi":"10.1016/j.ijgc.2025.101674","DOIUrl":"10.1016/j.ijgc.2025.101674","url":null,"abstract":"","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":" ","pages":"101674"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is modified radical hysterectomy the answer? 改良根治性子宫切除术是答案吗?
IF 4.1 2区 医学
International Journal of Gynecological Cancer Pub Date : 2025-06-01 Epub Date: 2025-04-22 DOI: 10.1016/j.ijgc.2025.101911
Marie Plante, Nadeem R Abu-Rustum
{"title":"Is modified radical hysterectomy the answer?","authors":"Marie Plante, Nadeem R Abu-Rustum","doi":"10.1016/j.ijgc.2025.101911","DOIUrl":"10.1016/j.ijgc.2025.101911","url":null,"abstract":"","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":"35 6","pages":"101911"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fertility-sparing approach for uterine smooth muscle tumors of uncertain malignant potential. 保留生育力入路治疗恶性潜能不确定的子宫平滑肌肿瘤。
IF 4.1 2区 医学
International Journal of Gynecological Cancer Pub Date : 2025-06-01 Epub Date: 2025-04-11 DOI: 10.1016/j.ijgc.2025.101822
Giorgio Bogani, Sabrina Croce, Giovanni Scambia, Wouter Froyman, Francesco Raspagliesi, Frederic Amant
{"title":"Fertility-sparing approach for uterine smooth muscle tumors of uncertain malignant potential.","authors":"Giorgio Bogani, Sabrina Croce, Giovanni Scambia, Wouter Froyman, Francesco Raspagliesi, Frederic Amant","doi":"10.1016/j.ijgc.2025.101822","DOIUrl":"10.1016/j.ijgc.2025.101822","url":null,"abstract":"<p><strong>Objective: </strong>Uterine smooth muscle tumors of uncertain malignant potential (STUMP) are a category of tumors that present diagnostic/therapeutic challenges since they cannot be assigned to either a benign or a malignant entity. Hysterectomy is the mainstay of treatment of STUMP. However, in most cases, STUMPs represent an incidental diagnosis following myomectomy. The optimal management of young women having an incidental diagnosis of STUMP following myomectomy is unclear. Only a few experiences are reported. This review focuses on the fertility-sparing treatment of STUMPs.</p><p><strong>Methods: </strong>This is a systematic review of studies comparing outcomes of patients undergoing hysterectomy and myomectomy. For this review, we included studies reporting outcomes of patients with STUMPs undergoing myomectomy. Studies reporting data only on radical treatment for STUMPs or focusing on conservative management of other uterine malignancies (including leiomyosarcoma) were excluded.</p><p><strong>Results: </strong>Pooled data of 327 patients (from 9 retrospective studies) were evaluated. Overall, the study included 159 (48.6%) and 168 (51.4%) patients who had myomectomy and hysterectomy, respectively. No differences in recurrence rates were observed after myomectomy and hysterectomy (13.2% vs 9.5%, OR 0.69, 95% CI 0.35 to 1.38, p = .30), after a median follow-up of 44 and 48 months, respectively. Patients treated with myomectomy were more likely to develop STUMP recurrences than patients treated with hysterectomy (11.9% vs 4.1%, OR 2.38, 95% CI 1.04 to 5.44, p = .046). Among 103 patients desiring to conceive, 40 (38.8%) patients achieved at least 1 pregnancy. Pregnancy was not associated with an increased risk of recurrence.</p><p><strong>Conclusions: </strong>These cumulative data suggest that myomectomy might be considered a safe and effective alternative for women who wish to preserve their childbearing potential. Centralization, pathology review based on clinic-pathologic and molecular integration, and multidisciplinary discussion in referral centers are of paramount importance. Multicenter prospective registries are needed.</p>","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":"35 6","pages":"101822"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
INTERLACE in practice. INTERLACE 在实践中的应用
IF 4.1 2区 医学
International Journal of Gynecological Cancer Pub Date : 2025-06-01 Epub Date: 2025-04-17 DOI: 10.1136/ijgc-2024-006098
Gemma Eminowicz, Patricia Diez, Mary McCormack
{"title":"INTERLACE in practice.","authors":"Gemma Eminowicz, Patricia Diez, Mary McCormack","doi":"10.1136/ijgc-2024-006098","DOIUrl":"10.1136/ijgc-2024-006098","url":null,"abstract":"","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":" ","pages":"101835"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modified radical hysterectomy for stage IB1 (≤2 cm) cervical cancer: assessment of temporal trends and oncologic outcomes in the United States. 改良根治性子宫切除术治疗IB1期(≤2 cm)宫颈癌:美国时间趋势和肿瘤预后评估
IF 4.1 2区 医学
International Journal of Gynecological Cancer Pub Date : 2025-06-01 Epub Date: 2025-02-01 DOI: 10.1016/j.ijgc.2025.101676
Koji Matsuo, Joel Agarwal, Ling Chen, Christian Pino, Mihiri S Karunaratne, Katelyn B Furey, Maximilian Klar, Lynda D Roman, Jason D Wright
{"title":"Modified radical hysterectomy for stage IB1 (≤2 cm) cervical cancer: assessment of temporal trends and oncologic outcomes in the United States.","authors":"Koji Matsuo, Joel Agarwal, Ling Chen, Christian Pino, Mihiri S Karunaratne, Katelyn B Furey, Maximilian Klar, Lynda D Roman, Jason D Wright","doi":"10.1016/j.ijgc.2025.101676","DOIUrl":"10.1016/j.ijgc.2025.101676","url":null,"abstract":"<p><strong>Objective: </strong>The oncologic safety of less-radical surgery for early-stage cervical cancer is currently being actively investigated. Given the paucity of data, this study assessed the temporal trends and oncologic outcomes associated with modified radical hysterectomy for stage IB1 (≤2 cm) cervical cancer in the United States.</p><p><strong>Methods: </strong>This retrospective cohort study used data from the Commission-on-Cancer's National Cancer Database. The study population was 2902 patients with clinical stage IB1 (≤2 cm) cervical cancer from 2010 to 2020. Temporal trends based on hysterectomy modality (radical hysterectomy, modified radical hysterectomy, and simple hysterectomy) were assessed using linear segmented regression with log-transformation, and the overall survival was assessed using a multivariable Cox proportional hazard regression model.</p><p><strong>Results: </strong>There was a statistically significant increase in modified radical hysterectomy from 2013 to 2020 (annual percentage rate increase 4.4, 95% CI 0.7 to 16.0, p=.040) and a decrease in simple hysterectomy from 2012 to 2020 (-2.3, 95% CI -3.7 to -1.3, p<.001). The lymphovascular space invasion rates (26.8%, 26.8%, and 23.1% for the radical, modified radical, and simple hysterectomy groups, respectively, p=.10) and pathological nodal metastasis rates (5.0%, 4.4%, and 4.0%, respectively, p=.54) were similar among the 3 groups. The use of adjuvant radiotherapy was higher in the simple hysterectomy group (13.0%, 13.0%, and 18.2% in the radical, modified radical, and simple hysterectomy groups, respectively, p<.001). The 5-year overall survival rates for radical hysterectomy, modified radical hysterectomy, and simple hysterectomy were 96.6%, 96.3%, and 95.8%, respectively (p=.66). In multivariable analysis, modified radical hysterectomy (adjusted HR 1.23, 95% CI 0.73 to 2.06) and simple hysterectomy (adjusted HR 1.02, 95% CI 0.70 to 1.48) were not associated with decreased overall survival compared with radical hysterectomy.</p><p><strong>Conclusions: </strong>The results of this cohort study in the United States suggest that modified radical hysterectomy for stage IB1 (≤2 cm) may not be associated with overall survival. This observed survival association warrants further investigation for stage IB1 (≤2 cm) cervical cancer that does not meet the low-risk criteria.</p>","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":" ","pages":"101676"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Revolutionizing first-line cervical cancer treatment: bevacizumab, immunotherapy, and emerging insights. 革命性的一线宫颈癌治疗:贝伐单抗,免疫疗法和新兴见解。
IF 4.1 2区 医学
International Journal of Gynecological Cancer Pub Date : 2025-06-01 Epub Date: 2025-01-28 DOI: 10.1016/j.ijgc.2025.101661
Wesley Antonio Lopes de Lima, Mariana Carvalho Gouveia, Louize Caroline Marques Oliveira, Mariana Scaranti
{"title":"Revolutionizing first-line cervical cancer treatment: bevacizumab, immunotherapy, and emerging insights.","authors":"Wesley Antonio Lopes de Lima, Mariana Carvalho Gouveia, Louize Caroline Marques Oliveira, Mariana Scaranti","doi":"10.1016/j.ijgc.2025.101661","DOIUrl":"10.1016/j.ijgc.2025.101661","url":null,"abstract":"","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":" ","pages":"101661"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Providing tertiary gynecologic oncology care for Quebec's indigenous population in Montreal. 提供三级妇科肿瘤护理魁北克的土著居民在蒙特利尔。
IF 4.1 2区 医学
International Journal of Gynecological Cancer Pub Date : 2025-06-01 Epub Date: 2025-04-25 DOI: 10.1016/j.ijgc.2025.101900
Gabriel Levin, Reitan Ribeiro, Lucy Gilbert, Shuk On Annie Leung, Joanne Power, Xing Zeng
{"title":"Providing tertiary gynecologic oncology care for Quebec's indigenous population in Montreal.","authors":"Gabriel Levin, Reitan Ribeiro, Lucy Gilbert, Shuk On Annie Leung, Joanne Power, Xing Zeng","doi":"10.1016/j.ijgc.2025.101900","DOIUrl":"10.1016/j.ijgc.2025.101900","url":null,"abstract":"","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":"35 6","pages":"101900"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence of lymph node metastases in patients with apparent early-stage endometrioid ovarian carcinoma. 早期子宫内膜样卵巢癌患者淋巴结转移的发生率。
IF 4.1 2区 医学
International Journal of Gynecological Cancer Pub Date : 2025-06-01 Epub Date: 2025-04-22 DOI: 10.1016/j.ijgc.2025.101897
Dimitrios Nasioudis, Stefan Gysler, Nawar A Latif, Robert L Giuntoli, Sarah H Kim, Emily M Ko
{"title":"Incidence of lymph node metastases in patients with apparent early-stage endometrioid ovarian carcinoma.","authors":"Dimitrios Nasioudis, Stefan Gysler, Nawar A Latif, Robert L Giuntoli, Sarah H Kim, Emily M Ko","doi":"10.1016/j.ijgc.2025.101897","DOIUrl":"10.1016/j.ijgc.2025.101897","url":null,"abstract":"<p><p>The incidence of lymph node metastases for apparent early-stage endometrioid ovarian carcinoma is not well-known. We accessed the National Cancer Database and selected patients with apparent stage I endometrioid ovarian carcinoma undergoing surgery between 2004 and 2015. The rate of lymphadenectomy was 76.9%, with a median of 12.5 lymph nodes removed. The overall incidence of lymph node metastasis was 2.2%, specifically, 1.2% for grade 1, 2.2% for grade 2, and 5.1% for grade 3 tumors (p < .001). After controlling for disease sub-stage, patients with grade 2 tumors were nearly twice (OR 1.78, 95% CI 1.20 to 2.63), and patients with grade 3 tumors were nearly 4 times (OR 4.1, 95% CI 2.74 to 6.22) as likely as those with grade 1 tumor to have lymph node metastases. Surgical staging identifies a very low rate of lymph node metastases for patients with apparent early-stage grade 1 endometrioid ovarian carcinoma, suggesting that lymphadenectomy can be omitted for these patients.</p>","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":"35 6","pages":"101897"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-port robotic fertility-sparing surgery for clear cell ovarian carcinoma. 透明细胞卵巢癌单孔机器人保生育手术。
IF 4.1 2区 医学
International Journal of Gynecological Cancer Pub Date : 2025-06-01 Epub Date: 2025-04-22 DOI: 10.1016/j.ijgc.2025.101899
Filippo Maria Capomacchia, Benedetta Alberghetti, Giacomo Guidi, Francesco Fanfani, Giovanni Scambia, Anna Fagotti, Luigi Carlo Turco
{"title":"Single-port robotic fertility-sparing surgery for clear cell ovarian carcinoma.","authors":"Filippo Maria Capomacchia, Benedetta Alberghetti, Giacomo Guidi, Francesco Fanfani, Giovanni Scambia, Anna Fagotti, Luigi Carlo Turco","doi":"10.1016/j.ijgc.2025.101899","DOIUrl":"10.1016/j.ijgc.2025.101899","url":null,"abstract":"","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":"35 6","pages":"101899"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radical parametrial resection with nerve-sparing approach: selective systematic nerve-sparing type C2 radical hysterectomy. 保留神经的宫旁根治性切除术:选择性系统性保留神经的 C2 型根治性子宫切除术。
IF 4.1 2区 医学
International Journal of Gynecological Cancer Pub Date : 2025-06-01 Epub Date: 2025-04-17 DOI: 10.1136/ijgc-2024-006079
Ilker Selcuk, Stoyan Kostov, Hakan Rasit Yalcin
{"title":"Radical parametrial resection with nerve-sparing approach: selective systematic nerve-sparing type C2 radical hysterectomy.","authors":"Ilker Selcuk, Stoyan Kostov, Hakan Rasit Yalcin","doi":"10.1136/ijgc-2024-006079","DOIUrl":"10.1136/ijgc-2024-006079","url":null,"abstract":"","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":" ","pages":"101834"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142371810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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