Survival outcomes in patients with recurrent mixed sex cord-stromal tumors of the ovary.

IF 4.7 2区医学 Q1 OBSTETRICS & GYNECOLOGY

International Journal of Gynecological Cancer Pub Date : 2025-10-01 Epub Date: 2025-07-25 DOI:10.1016/j.ijgc.2025.102018

Elio Tahan, Allison L Brodsky, Naomi R Gonzales, Alexandra Bercow, Anil K Sood, Lois M Ramondetta, David M Gershenson, R Tyler Hillman

{"title":"Survival outcomes in patients with recurrent mixed sex cord-stromal tumors of the ovary.","authors":"Elio Tahan, Allison L Brodsky, Naomi R Gonzales, Alexandra Bercow, Anil K Sood, Lois M Ramondetta, David M Gershenson, R Tyler Hillman","doi":"10.1016/j.ijgc.2025.102018","DOIUrl":null,"url":null,"abstract":"Objective: Mixed sex cord-stromal tumors of the ovary contain combinations of granulosa cell tumor components-either adult or juvenile subtypes-and/or Sertoli-Leydig cell tumor elements. The objective of this study is to evaluate survival outcomes in recurrent mixed sex cord-stromal tumors.Methods: This is a retrospective cohort study of recurrent mixed ovarian sex cord-stromal tumors identified through the MD Anderson Rare Gynecologic Malignancy Registry between 2000 and 2025. Comparative cohorts with recurrent, histologically uniform adult granulosa cell tumors, juvenile granulosa cell tumors, and Sertoli-Leydig cell tumors were included. Demographic and clinical characteristics were compared using descriptive statistics. Progression-free survival after first recurrence and overall survival from first recurrence were assessed using Kaplan-Meier methods and compared using log-rank tests.Results: Sixteen patients with recurrent mixed ovarian sex cord-stromal tumors were identified: 6 (37.5%) with adult granulosa cell plus Sertoli-Leydig cell tumors, 4 (25%) with juvenile granulosa cell plus Sertoli-Leydig cell tumors, and 6 (37.5%) with adult plus juvenile granulosa cell tumors. When comparing adult granulosa cell tumors to adult plus juvenile granulosa cell tumors, significant differences in median progression-free survival-2 (21.2 vs 8.7 months, p = .03) and overall survival (181.9 vs 83.8 months, p = .001) were observed. No significant differences in progression-free survival-2 (p = .7) or overall survival (p = .8) were noted between juvenile granulosa cell tumors and adult plus juvenile granulosa cell tumors. Among tumors with molecular testing results, 25% (1 of 4) of adult plus juvenile granulosa cell tumors, 25% (1 of 4) of adult granulosa cell plus Sertoli-Leydig cell tumors, and 33% (1 of 3) of juvenile granulosa cell plus Sertoli-Leydig cell tumors were positive for the c.C402G FOXL2 mutation.Conclusions: Recurrent adult plus juvenile granulosa cell tumors may exhibit more aggressive clinical behavior than uniform adult granulosa cell tumors, aligning more closely with juvenile granulosa cell tumors in recurrence outcomes.","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":"35 10","pages":"102018"},"PeriodicalIF":4.7000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Gynecological Cancer","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ijgc.2025.102018","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/25 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: Mixed sex cord-stromal tumors of the ovary contain combinations of granulosa cell tumor components-either adult or juvenile subtypes-and/or Sertoli-Leydig cell tumor elements. The objective of this study is to evaluate survival outcomes in recurrent mixed sex cord-stromal tumors.

Methods: This is a retrospective cohort study of recurrent mixed ovarian sex cord-stromal tumors identified through the MD Anderson Rare Gynecologic Malignancy Registry between 2000 and 2025. Comparative cohorts with recurrent, histologically uniform adult granulosa cell tumors, juvenile granulosa cell tumors, and Sertoli-Leydig cell tumors were included. Demographic and clinical characteristics were compared using descriptive statistics. Progression-free survival after first recurrence and overall survival from first recurrence were assessed using Kaplan-Meier methods and compared using log-rank tests.

Results: Sixteen patients with recurrent mixed ovarian sex cord-stromal tumors were identified: 6 (37.5%) with adult granulosa cell plus Sertoli-Leydig cell tumors, 4 (25%) with juvenile granulosa cell plus Sertoli-Leydig cell tumors, and 6 (37.5%) with adult plus juvenile granulosa cell tumors. When comparing adult granulosa cell tumors to adult plus juvenile granulosa cell tumors, significant differences in median progression-free survival-2 (21.2 vs 8.7 months, p = .03) and overall survival (181.9 vs 83.8 months, p = .001) were observed. No significant differences in progression-free survival-2 (p = .7) or overall survival (p = .8) were noted between juvenile granulosa cell tumors and adult plus juvenile granulosa cell tumors. Among tumors with molecular testing results, 25% (1 of 4) of adult plus juvenile granulosa cell tumors, 25% (1 of 4) of adult granulosa cell plus Sertoli-Leydig cell tumors, and 33% (1 of 3) of juvenile granulosa cell plus Sertoli-Leydig cell tumors were positive for the c.C402G FOXL2 mutation.

Conclusions: Recurrent adult plus juvenile granulosa cell tumors may exhibit more aggressive clinical behavior than uniform adult granulosa cell tumors, aligning more closely with juvenile granulosa cell tumors in recurrence outcomes.

查看原文本刊更多论文

卵巢混合性索间质肿瘤复发患者的生存结局。

目的：卵巢混合性索间质肿瘤包含颗粒细胞肿瘤成分（成人或青少年亚型）和/或支持间质细胞肿瘤成分的组合。本研究的目的是评估复发性混合性索间质肿瘤的生存结局。方法：这是一项回顾性队列研究，通过2000年至2025年MD安德森罕见妇科恶性肿瘤登记处发现的复发性混合卵巢性索间质肿瘤。包括复发的、组织学上一致的成人颗粒细胞肿瘤、青少年颗粒细胞肿瘤和支持-间质细胞肿瘤的比较队列。统计学和临床特征采用描述性统计进行比较。使用Kaplan-Meier方法评估首次复发后的无进展生存期和首次复发后的总生存期，并使用log-rank检验进行比较。结果：16例复发性卵巢性索间质混合肿瘤患者中，成人颗粒细胞+支持间质细胞肿瘤6例（37.5%），幼年颗粒细胞+支持间质细胞肿瘤4例（25%），成人+幼年颗粒细胞肿瘤6例（37.5%）。当将成人颗粒细胞肿瘤与成人+青少年颗粒细胞肿瘤进行比较时，观察到中位无进展生存期-2（21.2个月vs 8.7个月，p = 0.03）和总生存期（181.9个月vs 83.8个月，p = 0.001）的显著差异。少年颗粒细胞瘤和成人+少年颗粒细胞瘤的无进展生存期-2 （p = 0.7）或总生存期（p = 0.8）无显著差异。在分子检测结果的肿瘤中，25%（1 / 4）的成人+少年颗粒细胞肿瘤，25%（1 / 4）的成人颗粒细胞+ Sertoli-Leydig细胞肿瘤，33%（1 / 3）的少年颗粒细胞+ Sertoli-Leydig细胞肿瘤的c.C402G FOXL2突变阳性。结论：复发的成人和青少年颗粒细胞肿瘤可能比单一的成人颗粒细胞肿瘤表现出更强的临床行为，在复发结局上与青少年颗粒细胞肿瘤更接近。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Gynecological Cancer 医学-妇产科学

CiteScore

6.60

自引率

10.40%

发文量

280

审稿时长

3-6 weeks

期刊介绍： The International Journal of Gynecological Cancer, the official journal of the International Gynecologic Cancer Society and the European Society of Gynaecological Oncology, is the primary educational and informational publication for topics relevant to detection, prevention, diagnosis, and treatment of gynecologic malignancies. IJGC emphasizes a multidisciplinary approach, and includes original research, reviews, and video articles. The audience consists of gynecologists, medical oncologists, radiation oncologists, radiologists, pathologists, and research scientists with a special interest in gynecological oncology.