Best original research presented at the 26th European Congress on Gynaecological Oncology: Best of ESGO 2025.

The Best of ESGO 2025 manuscript highlights a selection of the best original research presented at the 26th Congress of the European Society of Gynaecological Oncology (ESGO), held in Rome, Italy on February 20 to 23, 2025. Of the 1583 abstracts submitted, the ESGO scientific program committee chairs and authors from the European Network of Young Gynae Oncologists selected 32 high-impact studies for inclusion in this compilation. This included 15 best oral sessions abstracts, 8 mini oral sessions abstracts, 7 young investigator session abstracts, and 2 best 3-minute presentations abstracts. The key research themes this year included surgical optimization in primary and recurrent ovarian cancer, advances in immunotherapy and maintenance strategies for endometrial and cervical cancer, patient-centered outcomes and quality of life, biomarker-driven approaches for treatment personalization, novel screening and diagnostic tools, and emerging targeted therapies for rare or treatment-resistant sub-types. Through this publication, the ESGO and European Network of Young Gynae Oncologists aimed to promote awareness and visibility of the most promising advances in gynecologic oncology research among clinicians, researchers, patients, patient advocacy groups, and allied professionals across Europe and worldwide.