International Journal of Impotence Research最新文献

{"title":"Long-term outcomes and risk factors for erectile dysfunction and penile curvature after surgical penile fracture repair.","authors":"Samet Senel, Huseyin Gultekin, Giray Ozgirgin, Lutfi Ihsan Boyaci, Melih Biyikoglu, Kazim Ceviz, Hasan Batuhan Arabaci, Emre Uzun, Antonios Koudonas","doi":"10.1038/s41443-025-01146-y","DOIUrl":"10.1038/s41443-025-01146-y","url":null,"abstract":"<p><p>Long-term outcomes of penile fracture (PF) include erectile dysfunction (ED) and penile curvature. In this study, we aimed to present the functional and anatomical results of 182 patients who underwent PF repair surgery and to reveal the risk factors for ED and penile curvature in a relatively long follow-up period. Thirty (16.5%) patients suffered from ED and 18 (9.9%) patients had penile curvature, respectively in a median follow-up period of 66 (39-111) months. Presence of bilateral fractures (OR = 7.806; 95% CI = 2.083-29.261; p = 0.002), larger tunical defect size (OR = 1.099; 95% CI = 1.036-1.164; p = 0.002) and longer time between fracture and surgery (OR = 1.095; 95% CI = 1.036-1.157; p = 0.001) were stated as the independent risk factors for ED. Only larger tunical defect size was found as an independent risk factor for penile curvature (OR = 1.14; 95% CI = 1.063-1.221; p < 0.001). The cut-off values for predicting ED were 18.5 mm for tunical defect size, 14.5 h for time between fracture and surgery, and 41 years for age. The cut-off value for tunical defect size was 18.5 mm for penile curvature. Risk of ED increases among patients with extended tunical rupture and delayed surgical repair. Penile curvature manifests less frequently and seems to be associated with the size of the tunical defect.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reservoir migration in inflatable penile prostheses: a systematic review and development of a clinical decision algorithm.","authors":"Erin Curran, Christopher Love","doi":"10.1038/s41443-025-01139-x","DOIUrl":"10.1038/s41443-025-01139-x","url":null,"abstract":"<p><p>The three-piece inflatable penile prosthesis (IPP) offers durable functional outcomes for men with medication-refractory erectile dysfunction. While rare, IPP reservoir migration can be significant. This systematic review aims to characterize the incidence of reservoir migration, assess migration outcomes across various placement techniques, and propose a clinical decision-making algorithm for reservoir placement. A comprehensive search of PubMed and the Cochrane Library was conducted on April 7, 2025, without filters. Eligible English-language studies reporting migration-related outcomes of functional IPP reservoirs were included. Data extraction and risk-of-bias assessments were performed using validated tools. Thirty-five studies were included: 19 case reports, 10 case series, and 6 cohort studies. A meta-analysis of proportions using a random-effects model was performed on 9 case series and 6 cohort studies (5783 patients), yielding a pooled migration rate of 0.2% (95% CI: 0.0%-0.6%) with moderate heterogeneity (I² = 54.2%). Sensitivity analyses yielded consistent results. The evidence is limited by small sample sizes, retrospective designs, and reporting variability. Migration risk is low but clinically significant and especially relevant in patients with altered pelvic anatomy. Based on findings, we propose a clinical algorithm incorporating patient risk factors to guide reservoir placement decisions.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revision rates of the AMS 800 artificial urinary sphincter: how it stacks up against other implants placed in men.","authors":"Steven K Wilson, John J Mulcahy, Ahmet T Albayrak, M David Schwalb","doi":"10.1038/s41443-025-01134-2","DOIUrl":"10.1038/s41443-025-01134-2","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of intravascular papillary endothelial hyperplasia (Masson’s tumor) of the penis","authors":"Muhammed A. M. Hammad,&nbsp;Elia Abou Chawareb,&nbsp;Jeffrey Lee,&nbsp;Mohammed Mahdi,&nbsp;Maryam Ahmadi,&nbsp;Giovanna Giannico,&nbsp;Faysal A. Yafi","doi":"10.1038/s41443-025-01136-0","DOIUrl":"10.1038/s41443-025-01136-0","url":null,"abstract":"Intravascular papillary endothelial hyperplasia (IPEH), or Masson’s tumor, is an uncommon, benign vascular lesion that can mimic malignant neoplasms. Although commonly found in the skin and soft tissues, its occurrence in the penis is extremely rare. We report the case of a 51-year-old male who presented with a painless, progressively enlarging penile mass. Imaging suggested a benign etiology, and the patient underwent surgical excision. Histopathological analysis confirmed the diagnosis of Masson’s tumor, revealing papillary endothelial proliferation within a thrombotic background. The postoperative course was uneventful, with satisfactory wound healing and no recurrence at follow-up. While rare, penile Masson’s tumor should be considered in the differential diagnosis of vascular penile lesions to avoid misdiagnosis and overtreatment. Surgical excision remains the definitive treatment, with excellent prognosis.","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":"37 9","pages":"794-796"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging innovation and integration: reflections on ESGURS-ESAU25 at University of Torino and the evolving landscape of reconstructive urology and andrology.","authors":"M Falcone, C Bettocchi, D Ralph, P Gontero","doi":"10.1038/s41443-025-01144-0","DOIUrl":"10.1038/s41443-025-01144-0","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in activation pumps for three-piece penile prostheses: a narrative review.","authors":"Mattia Lo Re, Marta Pezzoli, Esther Garcia Rojo, Manuel Alonso Isa, Celeste Manfredi, Bruno Bucca, Andrea Cocci, Francesco Sessa, Agustin Fraile Poblador, Andrea Minervini, Javier Romero-Otero","doi":"10.1038/s41443-025-01130-6","DOIUrl":"10.1038/s41443-025-01130-6","url":null,"abstract":"<p><p>The evolution of penile prosthesis pumps marks a significant milestone in the management of erectile dysfunction. Originating in the early 1970s, the development of multi-component hydraulic penile implants by Dr. F. Brantley Scott, Dr. Gerald Timm, and Dr. William Bradley laid the foundation for modern penile prostheses. Since the late 20th century, continuous advancements in inflatable penile prostheses have been introduced by various manufacturers, focusing on enhancing usability, minimizing complications, and improving patient satisfaction. These refinements have particularly emphasized the importance of pumps, critical to device functionality and overall patient experience. Recent innovations in prosthesis technology underscore the progress made in surgical techniques and the integration of advanced materials, leading to better clinical outcomes and heightened user satisfaction. This paper reviews the historical development, technological advancements, and current trends in penile prosthesis pumps. Although numerous studies have examined pump-related complications and patient satisfaction, a more comprehensive and systematically designed prospective research initiative is needed to investigate these challenges further.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Astaxanthin mitigates radiation-induced erectile dysfunction: protective effects on corpus cavernosum in a rat model.","authors":"Tarik Emre Sener, Omer Faruk Asker","doi":"10.1038/s41443-025-01140-4","DOIUrl":"10.1038/s41443-025-01140-4","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel rat model for investigating erectile function after nerve-sparing radical prostatectomy.","authors":"Yashou Guo, Ronggui Tao, Zhongyu Wang, Dali Jiang, Zejun Ren, Hengtong Fan, Xiaofeng Xu, Guoxiong Liu, Lin Yang, Dalin He","doi":"10.1038/s41443-025-01142-2","DOIUrl":"10.1038/s41443-025-01142-2","url":null,"abstract":"<p><p>The rehabilitation of erectile function post-radical prostatectomy remains a great challenge in clinical practice. We aimed to develop a novel rat model suitable for investigating erectile dysfunction (ED) following nerve-sparing radical prostatectomy (NSRP) and to validate its applicability. Thirty-two male Sprague-Dawley rats were randomly assigned to undergo either a novel NSRP modeling procedure or sham surgery. The surgical protocol for the NSRP group included identification and dissection of the major pelvic ganglia and cavernous nerve, prostatectomy, and reconstruction of the lower urinary tract. Mean arterial pressure (MAP) and intracavernous pressure (ICP) were assessed at 1 and 2 weeks postoperatively. Subsequently, the penis tissues were collected for histopathological analyses. The results showed that rats in the NSRP group exhibited significantly lower maximum ICP/MAP ratios (0.39 ± 0.17 vs 0.77 ± 0.08, P < 0.0001) and areas under the ICP curve (2090.13 ± 1050.15 vs 4326.08 ± 1042.08, P = 0.0001) compared to the sham-operated group at 1 week postoperatively. By 2 weeks postoperatively, the NSRP group showed a significant improvement in both the maximum ICP/MAP ratio (0.73 ± 0.09 vs 0.39 ± 0.17, P < 0.0001) and the area under the ICP curve (3654.40 ± 679.28 vs 2090.13 ± 1050.15, P = 0.005) compared to the 1-week post-NSRP group. However, the area under the ICP curve in the NSRP group remained significantly lower than that in the sham-operated group at 2 weeks postoperatively (3654.40 ± 679.28 vs 5259.10 ± 951.48, P = 0.003). Similarly, histological staining suggested that smooth muscle atrophy and collagen deposition in the penis gradually improved over time post-NSRP. However, significant differences in the ratio of smooth muscle to collagen remained between the NSRP and sham-operated groups at 2 weeks postoperatively (0.22 ± 0.03 vs 0.27 ± 0.05, P = 0.011). In conclusion, this study established a novel rat model for investigating post-NSRP ED and validated its utility through erectile function monitoring and histological analysis. Further promising preclinical studies using this model are necessary to explore underlying mechanisms and evaluate the efficacy of treatments for post-NSRP ED.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of life outcomes following penile prosthesis insertion in the post-ischaemic priapism setting.","authors":"Isabel Dighero, Katy Naylor, Aisling Looney, Fiona Holden, Chloe Mount, Mark Johnson, Wai Gin Lee, David Ralph, Philippa Sangster","doi":"10.1038/s41443-025-01073-y","DOIUrl":"https://doi.org/10.1038/s41443-025-01073-y","url":null,"abstract":"<p><p>Penile prosthesis insertion is recommended for long-duration ischaemic priapism patients with refractory erectile dysfunction. There is a paucity of published data focusing on long term outcomes and quality of life reporting for patients in this setting. We contacted patients who had a post-ischaemic priapism penile prosthesis inserted in our department via telephone and conducted the previously validated Quality of Life and Sexuality with Penile Prosthesis (QoLSPP) questionnaire. Question items were answered on a Likert scale from 0-5 with satisfactory scores ≥3. Two-tailed Z-tests were used to determine satisfactory scores at significant levels (p < 0.05). We chose to add two additional questions on regret and feelings towards living the rest of their lives with a penile prosthesis. 167 patients had penile prostheses inserted post- ischaemic priapism between 2002-2022. Of these, 39 (23.4%; implants between 2007-2021) completed our questionnaire. The median age was 56 years (IQR 50-63) with a median time to questionnaire post-ischaemic priapism of 9 years (IQR 3-11). Analysing the QoLSPP mean item responses, the penile prosthesis resulted in satisfactory scores in 7 of 16 QoLSPP questionnaire items: device adequacy, device rapidity, device duration, meeting expectations, contentment with life, general well-being and sexual experience. The pooled mean score by domain was 3.7 ± 1.2 for functional, 3.3 ± 1.4 for relational, 3.2 ± 1 for social and 3.4 ± 1.1 for personal. Sub-group analysis demonstrated no significant difference in mean score by prosthesis type (inflatable versus malleable). Ten respondents cited specific reasons for how the penile prosthesis caused dissatisfaction. All 39 respondents (100%) answered 'yes', they did not regret penile prosthesis insertion as a treatment option and that they would be satisfied living the remainder of their lives with a device in situ. This study can be used to inform patient counselling, that penile prosthesis insertion is a suitable surgical technique to maintain sexual function post-ischaemic priapism.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Men with delayed ejaculation report lower sexual satisfaction and more depressive symptoms than those with premature ejaculation: findings from a cross-sectional study.","authors":"Fausto Negri, Christian Corsini, Edoardo Pozzi, Massimiliano Raffo, Alessandro Bertini, Gabriele Birolini, Alessia d'Arma, Luca Boeri, Francesco Montorsi, Michael L Eisenberg, Andrea Salonia","doi":"10.1038/s41443-025-01131-5","DOIUrl":"10.1038/s41443-025-01131-5","url":null,"abstract":"<p><p>Delayed ejaculation (DE) is among the most challenging male sexual dysfunctions. We aim to explore and compare socio-demographic and clinical characteristics of men with self-reported DE and primary premature ejaculation (PE). Data from 555 consecutive men seeking first medical help for DE or primary PE were retrospectively analyzed. Socio-demographic, clinical, laboratory data, and self-reported symptoms of anxiety and depression were collected. Patients completed International Index of Erectile Function (IIEF) and Beck Depression Inventory (BDI). We excluded men who had undergone pelvic surgery. Descriptive statistics compared clinical and socio-demographic characteristics. Linear regression models tested the association between depressive symptoms and baseline IIEF domain scores among men with DE. Of 555 patients, 479(86.3%) and 76(13.7%) had PE and DE, respectively. Men with DE were significantly older than those with PE [47(34-63.5) vs. 44(33-53), P = 0.01]. Conversely, men with PE depicted a CCI ≥ 1 more frequently compared to those with DE [17(22.4%) vs. 53(11.1%); P = 0.01]. The two groups did not differ regarding relational status, BMI, waist circumference, and hormonal milieu. Men with DE reported more frequently symptoms referable to anxiety and depression (P = 0.001) along with higher median (IQR) baseline BDI scores [8(4.8-14.3) vs. 6(2-10); P = 0.01], lower median IIEF-orgasmic function (OF) [6(5-9) vs. 9(6-10); P = 0.003] and IIEF-sexual desire (SD) [7(5.8-8) vs. 8(6-9); P = 0.001] domain scores compared to men with PE. At linear regression analysis, in men with DE, the higher the BDI score the lower the IIEF-overall satisfaction [β = -1.57, CI(-2.60, -0.53), P = 0.004], and the lower the IIEF-intercourse satisfaction [β = -0.76, CI(-1.29, -0.16), P = 0.01] domain scores. Conversely, no association between BDI and IIEF-OF, -SD, and -erectile function domain scores were found. Of men complaining of ejaculatory disorders, one out of ten reports DE. Patients with DE have higher chances to report clinically significant depression which can significantly impact their overall sexual satisfaction.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}