International Journal of Impotence Research最新文献

{"title":"Nerve graft for erectile dysfunction after radical prostatectomy: animal study and clinical data-a narrative review.","authors":"Tung Shu, Danqing Ren, Yanna Cao, Run Wang","doi":"10.1038/s41443-024-01000-7","DOIUrl":"https://doi.org/10.1038/s41443-024-01000-7","url":null,"abstract":"<p><p>Introduced in the late 1990s, nerve grafting, particularly with sural and genitofemoral nerves, aims to enhance erectile function recovery when neurovascular bundles cannot be preserved following radical prostatectomy. Over the past three decades, researchers have conducted numerous animal and clinical studies to explore the application and clinical effectiveness of this method, with the hope of benefiting patients suffering from erectile dysfunction after radical prostatectomy. Animal studies have demonstrated the potential of various grafting materials, including autologous nerve and vein grafts, and bioengineered grafts, in promoting nerve regeneration and erectile function recovery. Clinical studies, especially those focusing on sural and genitofemoral nerve grafts, have shown mixed results with varied success rates due to methodological weaknesses and small sample sizes. This review thoroughly incorporates current data, explores emerging nerve grafting methods, demonstrates the complexity of nerve grafting outcomes, and emphasizes the necessity for continuous research, including multi-institutional randomized controlled trials, to establish standardized protocols and optimize patient selection for nerve grafting in the management of erectile dysfunction after radical prostatectomy.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of relative fat mass with prevalence of erectile dysfunction in US men: an analysis of NHANES 2001-2004.","authors":"Xingliang Feng, Nuo Ji, Bo Zhang, Wei Xia, Yiming Chen","doi":"10.1038/s41443-024-01003-4","DOIUrl":"https://doi.org/10.1038/s41443-024-01003-4","url":null,"abstract":"<p><p>The high prevalence of erectile dysfunction (ED) underscores the critical importance of interventions and preventive measures targeting potential risk factors, among which obesity stands out. Relative fat mass (RFM) emerges as a superior indicator for quantifying body fat compared to traditional metrics like body mass index (BMI) or waist circumference (WC). However, research on the relationship between RFM and ED is extremely limited. A total of 3627 participants from the National Health and Nutrition Examination Survey 2001-2004 were eligible for analysis. The RFM is calculated using the following formula: RFM = 64-(20×height/WC). Weighted multivariable logistic regression models were utilized to assess the correlation between RFM and ED, supplemented by smooth curve fitting to further explore the linear association. When all potential covariates adjusted, continuous RFM demonstrated a positive association with ED prevalence (odds ratio (OR): 1.11, 95% confidence interval (CI): 1.05-1.18, P = 0.002). When RFM was categorized into tertiles (T1-T3), participants in T3 group exhibited a significantly higher likelihood of ED (OR: 2.19, 95% CI: 1.19, 4.05, P = 0.020) compared to those in T1. Subgroup analyses revealed a stronger correlation among participants aged over 60 years, obese individuals, and those with hypertension, while weaker correlations were observed among those with diabetes and cardiovascular disease (CVD). After sensitivity analysis for severe ED, the aforementioned regression analysis results remained statistically significant. The final ROC analysis demonstrated that the predictive ability of RFM was superior to that of BMI and WC, with an AUC (95% CI) of 0.639 (0.619-0.659). Elevated RFM demonstrated a linear correlation with increased incidence of ED and exhibited strong predictive capability for ED, underscoring the importance of obesity intervention for ED. Future studies with larger clinical samples are necessary to confirm our findings and expand the application value of RFM in assessing ED risk.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perception of orgasmic intensity changes between clitorally and vaginally activated orgasm: a psychometric analysis using the Orgasmometer scale.","authors":"Andrea Sansone, Daniele Mollaioli, Elena Colonnello, Giacomo Ciocca, Erika Limoncin, Tommaso B Jannini, Fiorenza Pesce, Emmanuele A Jannini","doi":"10.1038/s41443-024-00999-z","DOIUrl":"https://doi.org/10.1038/s41443-024-00999-z","url":null,"abstract":"<p><p>Female orgasmic experience and intensity depend on several biological, anatomical, cultural, psychological and relational factors, yet studies have not explored how receptiveness to different stimulations (clitoral, vaginal, or both) affects subjectively perceived orgasmic intensity. Using data from sexually active, heterosexual women in two Italian nationwide surveys from 2021 and 2023, we evaluated orgasmic experience, sexual and psychological well-being using validated psychometric tools (FSFI, Orgasmometer, GAD-7, PHQ-9), also considering several socio-demographic factors, aiming to identify changes in terms of subjectively perceived orgasmic intensity according to different stimulations. The two surveys (Sex@COVID study, from April 7^th to May 4^th, 2020, n = 6821; and the FATHER Study, from May 12^th to June 12^th, 2023, n = 1845) were hosted on a dedicated website and were advertised through social media, radio broadcast, and interviews on national newspapers. Among 1,799 women meeting inclusion criteria, 40.7% primarily experienced clitorally activated orgasms (CAO, n = 733), 18% vaginally activated orgasms (VAO, n = 324), and 41.2% both types (Clitorally and Vaginally Activated Orgasms, CaVAO, n = 742). Significant psycho-sexological differences between the two studies were observed, with additional evidence suggesting the impact of lockdown and social distancing on sexual outcomes. Women experiencing CaVAO attained the highest FSFI and Orgasmometer scores, followed by those with VAO, and lastly, those with CAO (p < 0.001 for both). Regression analysis confirmed the same trend for Orgasmometer scores (R² = 0.247, p < 0.001), also highlighting the relevance of sexual dysfunction (according to FSFI, β = -1.34 ± 0.08, p < 0.001) for orgasmic intensity. Lastly, women preferring masturbation to partnered sexual activity had lower orgasmic intensity (β = -0.41 ± 0.07, p < 0.001). Age, psychological status and relationship status had no significant effect on the model. Despite some limitations, this is the first study addressing the association between receptiveness to different stimulations and orgasmic intensity on a large sample using validated psychometric instruments.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to comment on: can AI Chatbots accurately answer patient questions regarding vasectomies?","authors":"Edwin Mouhawasse, Christopher W Haff, Preet Kumar, Justin M Dubin","doi":"10.1038/s41443-024-00996-2","DOIUrl":"https://doi.org/10.1038/s41443-024-00996-2","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The often missed diagnosis of somatic symptom disorder in sexual dysfunction: recognizing symptoms and management tips for clinicians.","authors":"Paraskevi-Sofia Kirana","doi":"10.1038/s41443-024-00994-4","DOIUrl":"https://doi.org/10.1038/s41443-024-00994-4","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peri-transplant testosterone levels amongst lung transplant recipients: a call for national collaboration.","authors":"Austin Thompson, Danly Omil-Lima, Nannan Thirumavalavan","doi":"10.1038/s41443-024-00987-3","DOIUrl":"https://doi.org/10.1038/s41443-024-00987-3","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: endocrine effect of phthalates metabolites and a butterfly effect of prenatal exposure to androgens on qualitative aspects of female sexual response- an initial survey.","authors":"Alessandra Logoteta, Dake Zhu, Emmanuele A Jannini","doi":"10.1038/s41443-024-00993-5","DOIUrl":"10.1038/s41443-024-00993-5","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Safety of penile prosthesis implantation in solid organ transplant recipients: a systematic review.","authors":"Edoardo Pozzi, Ranjith Ramasamy","doi":"10.1038/s41443-024-00995-3","DOIUrl":"10.1038/s41443-024-00995-3","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of diagnosis and treatment of penile cancer on intimacy: a qualitative assessment.","authors":"Camille Roumieux, Laurence Royakkers, Maarten Albersen, Eline Dancet","doi":"10.1038/s41443-024-00992-6","DOIUrl":"https://doi.org/10.1038/s41443-024-00992-6","url":null,"abstract":"<p><p>Penile cancer is a rare malignancy (0.5-0.93/100,000 in Western countries) with significant psychosocial and sexual repercussions. This qualitative study explored the impact of penile cancer diagnosis and treatment on intimacy. A convenience sample was identified of 20 potential candidates who were at least 5 months post penile cancer surgery at a hospital centralizing penile cancer care. Participants were recruited by telephone and admitted until data saturation was reached, resulting in a sample of nine men (44-74 years old), none withdrew from participation. All interviews were performed by the same female researcher with no prior relationship to the men. The one-time interviews (35-61 min) followed a semi-structured interview guide, were audio-recorded and transcribed verbatim. Three researchers analysed the data independently using descriptive phenomenological analysis, resulting in a gradually drawn up coding tree mapping out the patient's journey. The central themes that emerged were: (1) Intimate area led to diagnostic delays, intensified diagnosis and induced secrecy; (2) Impact on sexuality prior to surgery; (3) The voyage of sexual re-discovery; (4) A partnered voyage of sexual discovery; (5) Care needs related to intimate area. This study highlights the need for comprehensive and personalized care, including pre-surgical information provision and post-surgical psychosexual support. Addressing the current unmet needs of men with penile cancer requires guidelines for psychosexual interventions and proactive efforts to reduce stigma and to raise awareness.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Penile prosthesis implantation is safe and effective in Peyronie’s Disease patients with and without erectile dysfunction","authors":"Matthew Ziegelmann","doi":"10.1038/s41443-024-00977-5","DOIUrl":"10.1038/s41443-024-00977-5","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":"37 1","pages":"101-102"},"PeriodicalIF":2.8,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}