International Journal of Impotence Research最新文献

{"title":"The outcomes of inflatable penile prosthesis implantation in the context of Genital Gender Affirming Surgery in Assigned Female At Birth patients: A comparative study between cis-male Dacron modified and Zephyr Surgical Implants 475 Female To Male Penile Prosthesis.","authors":"Marco Falcone, Federica Peretti, Mirko Preto, Lorenzo Cirigliano, Ilaria Ferro, Natalia Plamadeala, Martina Scavone, Emanuele Zupo, Paolo Gontero","doi":"10.1038/s41443-025-01137-z","DOIUrl":"10.1038/s41443-025-01137-z","url":null,"abstract":"<p><p>The ideal device to be implanted into a neophallus has yet to be identified. Since 2016 Zephyr Surgical Implant 475 Female To Male (ZSI 475 FtM, Switzerland) series penile prosthesis (PP) have been proposed as \"ad hoc\" device. The aim of the study is to compare the outcomes of cis-male Dacron modified PP with ZSI 475 FTM PP. A single-center prospective study was performed between March 2011 and April 2024. Patients received either the implantation of a cis-male Dacron modified PP or ZSI 475 FTM PP. The primary endpoint was the comparison of the surgical outcomes. The secondary endpoint was the evaluation of device survival. 47 assigned female at birth (AFAB) patients were included in: 29 underwent a cis-male Dacron modified PP, 18 received ZSI 475 FTM PP. The median follow-up was 36 months (IQR 13-70). A significantly shorter operative time was observed in ZSI FTM PP group when compared to cis-male Dacron modified PP group (mean value of 85 (IQR 78-97) VS. 105 (IQR 89-150) minutes, p 0.001). No statistically significant differences were found regarding the rate of postoperative complications, although the cis-male Dacron-modified PP appeared to have a higher tendency for infection (24.1% vs. 5.6%) and mechanical failure (31% vs. 22.2%, p = 0.09 and p = 0.51, respectively) compared with the ZSI 475 FTM PP. Explantation free survival (EFS) at 12 months was higher in the ZSI 475 FTM PP group (100 VS. 79.3%, p-value 0.039). However, at 24 months, this advantage was lost (94.4% VS. 72.4%, p value 0.062). Both cis-male Dacron modified and ZSI 475 FTM PP may guarantee satisfactory surgical outcomes. High powered prospective trials are warranted to confirm the data.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variations in diagnostic criteria for male hypogonadism: is there a need for standardizing specialist society guidelines?","authors":"Georgios Tsampoukas, Sourabh Karna, Afonso Morgado, Suks Minhas","doi":"10.1038/s41443-025-01128-0","DOIUrl":"10.1038/s41443-025-01128-0","url":null,"abstract":"<p><p>Male hypogonadism or testosterone deficiency is characterized by impaired testicular function resulting in reduced androgen production and altered spermatogenesis. The prevalence of late-onset hypogonadism is approximately 2.1% among men aged 40-79 years but it can reach 30% in specific populations. Despite its clinical impact and a market projected to reach $5.1 billion by 2030, there are discrepancies among specialist societies regarding nomenclature, diagnostic cutoffs, and classification. This narrative review discusses the guidance from: the European Association of Urology (EAU), American Urological Association (AUA), Endocrine Society (EnS), Society for Endocrinology (SfE), European Academy of Andrology (EAA), British Society for Sexual Medicine (BSSM), Italian Society of Andrology and Sexual Medicine (SIAMS), Italian Society of Endocrinology (SIE), and the International Society for Sexual Medicine (ISSM). Societies approach the condition differently in terms of nomenclature (Male Hypogonadism vs Testosterone Deficiency), classification, biochemical criteria, and follow-up protocols. Some organizations, including the EAU, SfE, SIAMS & SIE, favour \"male hypogonadism,\" spotlighting diminished testicular function in both testosterone and sperm production. Others, like the AUA, BSSM, and ISSM, prefer \"Testosterone Deficiency,\" emphasizing symptomatic low Testosterone levels. Classifications often distinguish primary from secondary causes, but several guidelines adopt categories such as functional or compensated hypogonadism. Finally, divergent diagnostic cutoffs for total and free testosterone create \"gray zones\" and differing follow-up recommendations-particularly around Prostatic Specific Antigen (PSA) and haematocrit (Hct)-underscore the need for standardization. As these inconsistencies may affect clinical practice and research, consensus-based, collaborative efforts from international expert panels are needed to establish universally accepted guidelines that address the current variability in male hypogonadism.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Male sexual dysfunction associated with GLP-1 receptor agonists: a cross-sectional analysis of FAERS data","authors":"Edoardo Pozzi,&nbsp;Gabriele Birolini,&nbsp;Simona De Luca,&nbsp;Andrea Salonia","doi":"10.1038/s41443-025-01126-2","DOIUrl":"10.1038/s41443-025-01126-2","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":"37 8","pages":"691-692"},"PeriodicalIF":2.5,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for the special issue on “Endocrine system and sexology”","authors":"Emmanuele A. Jannini","doi":"10.1038/s41443-025-01117-3","DOIUrl":"10.1038/s41443-025-01117-3","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":"37 8","pages":"573-573"},"PeriodicalIF":2.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41443-025-01117-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Male sexual dysfunction associated with GLP-1 receptor agonists: a cross-sectional analysis of FAERS data","authors":"Taylor P. Kohn,&nbsp;Larry I. Lipshultz","doi":"10.1038/s41443-025-01121-7","DOIUrl":"10.1038/s41443-025-01121-7","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":"37 8","pages":"686-687"},"PeriodicalIF":2.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative complication severity prediction in penile prosthesis implantation: a machine learning-based predictive modeling study.","authors":"Ali Ünal, Ali Şahin, Mesut Altan, İhsan Batuhan Demir, İyimser Üre, Hazım Alparslan Mazlum, Lorenzo Cirigliano, Mirko Preto, Marco Falcone, Murat Gül","doi":"10.1038/s41443-025-01135-1","DOIUrl":"https://doi.org/10.1038/s41443-025-01135-1","url":null,"abstract":"<p><p>Prediction of postoperative complications is crucial in surgical care, particularly for penile prosthesis implantation. We retrospectively evaluated demographic, clinical, laboratory, and surgical data from patients who underwent penile prosthesis implantation between 2015 and 2023. Six machine learning algorithms-Gradient Boosting (GB), AdaBoost, Support Vector Machine (SVM), Random Forest (RF), XGBoost (XGB), and Naive Bayes (NB)-were trained to predict the occurrence and severity of postoperative complications. Model performance was assessed using accuracy, F1 score, sensitivity, specificity, Youden Index, and AUC value, and statistical comparisons identified the most effective approach. The GB model achieved the highest F1 score (0.86 ± 0.09; 95% CI, 0.84-0.87), significantly outperforming other models. Sensitivity was greatest for GB and XGB (0.78 ± 0.13; 95% CI, 0.75-0.80), with GB superior to AdaBoost and SVM (p < 0.001). RF demonstrated the highest specificity (1.00 ± 0.00; 95% CI, 1.00-1.00), exceeding AdaBoost, SVM, and NB (p < 0.001). GB best predicted mild complications (0.74 ± 0.14; 95% CI, 0.72-0.77), while NB excelled for severe complications (0.94 ± 0.17; 95% CI, 0.90-0.98). Overall accuracy was 0.90 ± 0.04 (95% CI, 0.89-0.90) for both GB and RF. Feature analysis highlighted HbA1c, total testosterone, and urea as key predictors. Implementing GB-based machine learning may enhance surgical decision-making in this setting.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of solid organ transplantation on sexual dysfunction and infertility in older men and women: A Claims Based Study.","authors":"Obinna Obuekwe, Haley Clark, Gal Saffati, Tatyana Yatsenko, Laura Oscar-Thompson, Carlos Riveros, Akhil Muthigi","doi":"10.1038/s41443-025-01127-1","DOIUrl":"10.1038/s41443-025-01127-1","url":null,"abstract":"<p><p>Solid organ transplantation (SOT) restores organ function and prolongs survival, but its impact on sexual dysfunction and infertility is underexplored. This study evaluated changes in their prevalence before and after transplantation across organ types. We conducted a retrospective cohort study using TriNetX, including 64 932 U.S. adults (≥18 years) who underwent heart, kidney, liver, lung, or pancreas transplants within the past 20 years. Sexual dysfunction (e.g., erectile dysfunction, dyspareunia) and infertility were identified using ICD-10 codes. Pre-post analysis assessed relative and absolute risk reduction (ARR). Analyses were stratified by sex and organ type. SOT was associated with reduced sexual dysfunction (ARR 1.40%, p < 0.001) and infertility (ARR 0.10%, p = 0.013). Males experienced a greater reduction in sexual dysfunction (ARR 2.11%, p < 0.001) than females (ARR 0.20%, p = 0.035). Sexual dysfunction declined following heart (ARR 2.21%, p = 0.001), kidney (ARR 1.42%, p < 0.001), lung (ARR 1.24%, p = 0.042), and liver (ARR 0.74%, p = 0.003) transplants. No difference was seen following pancreas transplantation, and infertility prevalence did not differ across SOT types. These findings suggest SOT may improve sexual health, particularly in men, though effects on infertility remain limited.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hard-flaccid syndrome: a systematic review of aetiopathophysiology, clinical presentation and management.","authors":"Karl H Pang, Jiarong Feng, Yan Zhang","doi":"10.1038/s41443-025-01118-2","DOIUrl":"https://doi.org/10.1038/s41443-025-01118-2","url":null,"abstract":"<p><p>Hard-flaccid syndrome (HFS) is a rare condition characterised by a semi-rigid penis in the flaccid state, often accompanied by perineal and urinary symptoms. It may also induce psychological distress, which can exacerbate physical symptoms, creating a vicious cycle. There is currently no standardised treatment for HFS, and management typically focuses on addressing both the underlying causes and presenting symptoms. A systematic review of the literature identified 8 eligible studies. Although the exact aetiopathogenesis remains unclear, it is hypothesised that an initial penile trauma may trigger a cascade of neurovascular and inflammatory events. The associated psychological impact may further perpetuate symptoms, reinforcing the cycle of dysfunction. Common symptoms include perineal pain, urinary disturbances, and erectile and ejaculatory dysfunction. Evaluation involves a comprehensive clinical history, relevant blood and radiological investigations to exclude other pathologies, and the use of symptom questionnaires. Reported treatments include phosphodiesterase-5 inhibitors, anxiolytics, low-intensity shockwave therapy, pelvic floor physical therapy, spinal surgery, and biopsychosocial therapy. Management should be individualised, with a focus on relieving symptoms and breaking the self-perpetuating cycle of HFS. Further evidence-based studies are needed to better understand the pathophysiology of HFS, as well as to develop clear diagnostic criteria and management guidelines.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silicone penile prosthesis without suprapubic lipectomy for buried penis: a pilot study on the efficacy of Himplant^TM.","authors":"James Elist, Keon Amirazodi, Kambiz Tajkarimi, Adam De Fazio, Britney L Atwater, Steven K Wilson","doi":"10.1038/s41443-025-01125-3","DOIUrl":"https://doi.org/10.1038/s41443-025-01125-3","url":null,"abstract":"<p><p>Adult acquired buried penis (AABP) is a condition where the penile shaft becomes concealed by surrounding tissues, often due to obesity, leading to significant physical and psychological distress. This pilot study evaluates the efficacy of Himplant^TM (International Medical Devices Inc., Beverly Hills, CA, USA), a subcutaneous silicone penile prosthesis, for correcting AABP without concurrent manipulation of suprapubic fat. Twelve adult patients (mean age 39.1 ± 10.8 years) underwent Himplant^TM insertion between January 2023 and May 2024. Standardized pre- and postoperative measurements showed a mean increase of 3.52 ± 0.41 cm in flaccid dorsal length and 2.78 ± 0.54 cm in midshaft girth (p < 0.0001). A non-validated follow-up questionnaire revealed that 85.7% of respondents (6/7) reported improved self-confidence in both daily life and sexual activity. The overall complication rate was low and limited to minor, conservatively managed issues; there were no penile infections, penile skin erosions, or other cases requiring implant removal. Notably, no recurrences of AABP were observed during a median follow-up period of 16.5 months. These findings suggest that Himplant^TM may offer a safe, effective, and minimally invasive surgical solution for AABP, improving both functional outcomes and psychosocial well-being.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dimensions of sexual self-concept and sexual dysfunctions in middle-aged men: results of the Bavarian Men's Health-Study.","authors":"Valentin H Meissner, Victoria A Söhne, Andreas Dinkel, Matthias Jahnen, Stefan Schiele, Martina Kron, Jürgen E Gschwend, Kathleen Herkommer","doi":"10.1038/s41443-025-01119-1","DOIUrl":"https://doi.org/10.1038/s41443-025-01119-1","url":null,"abstract":"<p><p>Sexual self-concept is multidimensional and a key construct in understanding people's sexuality. The etiology as well as the relationship and causal direction between its different dimensions and sexual dysfunctions are not fully understood. A population-based cohort (N = 5665) of 50-year-old men completed questionnaires on dimensions of sexual self-concept (toughness, body image, sexual self-esteem, and perceived pressure with regard to sexuality) and sexual dysfunctions. Associations were assessed using multivariable linear regression analyses. Erectile dysfunction (ED), lifelong/acquired and subjective/variable premature ejaculation (PE), and low libido (LL) were associated with a more negative body image (p < 0.001), lower sexual self-esteem (p < 0.001), and higher perceived pressure with regard to sexuality (p < 0.001). ED, lifelong/acquired and subjective/variable PE were associated with toughness (p < 0.001), an association with LL could not be shown. A negative sexual self-concept was independently associated with sexual dysfunctions in middle-aged men highlighting that sexual self-concept represents a relevant factor in the biopsychosocial conception of sexual dysfunctions. The causal direction of this relationship needs to be determined in longitudinal studies.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}