{"title":"The role of vacuum erection device and penile traction therapy in the patients after radical prostatectomy: a narrative review.","authors":"Tung Shu, Danqing Ren, Run Wang","doi":"10.1038/s41443-025-01092-9","DOIUrl":"https://doi.org/10.1038/s41443-025-01092-9","url":null,"abstract":"<p><p>Radical prostatectomy (RP) is a common treatment for localized prostate cancer, which unfortunately often results in sexual dysfunction, including, but not limited to erectile dysfunction (ED), penile atrophy and penile fibrosis. Various therapies have been used to manage these side effects associated with RP, including vacuum erection devices (VEDs) and penile traction therapy (PTT). This review focuses on the mechanisms, efficacy, and clinical applications of VED and PTT in post-RP patients. VED, a well-established, non-invasive modality, enhances penile blood flow, preserves tissue integrity, and facilitates early engagement in sexual activity. Although VED has been shown to help maintain penile length and improve sexual function, its effectiveness in accelerating spontaneous erectile function recovery remains uncertain. PTT, originally developed for Peyronie's disease, has recently been explored for post-RP patients. Preliminary studies suggest its potential in mitigating penile shortening and supporting functional recovery, though long-term efficacy data remain limited. Both therapies face challenges, including lack of standardized protocols, adherence issues, and encouraging, but limited evidence on their combined use with pharmacological interventions. Additionally, factors such as patient education, treatment accessibility, and psychological support play critical roles in therapy adherence and overall success. Further research is needed to optimize treatment protocols, improve patient compliance, and establish the role of VED and PTT in comprehensive post-RP care through large-scale, well-designed clinical trials.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Camille Roumieux, Kaat Vandermaesen, Eline Dancet, Maarten Albersen
{"title":"Penile cancer treatment and sexuality: a narrative review.","authors":"Camille Roumieux, Kaat Vandermaesen, Eline Dancet, Maarten Albersen","doi":"10.1038/s41443-025-01095-6","DOIUrl":"https://doi.org/10.1038/s41443-025-01095-6","url":null,"abstract":"<p><p>Penile squamous cell carcinoma is a rare malignancy that poses a significant concern to those affected due to its aggressive nature and profound impact on patients' quality of life. This review examines the evidence on the impact of penile cancer and its various treatments on the sexual health of patients. Men's post-surgical sexual functioning has mainly been assessed with the International Index of Erectile Functioning. Some studies asked men to report retrospectively on pre-surgical sexual functioning or compared surgical techniques with non-randomized samples. Studies on patient's perspectives on sexual sensations and appearance are emerging, however reliable assessments of sexual wellbeing are missing. Penile cancer significantly impacts patients' sexual activity, sexual function, sexual sensations, cosmesis and sexual wellbeing. Considerable proportions of patients resume sexual activity following treatments, including organ-sparing procedures, partial or total penectomy, and adjuvant therapies. While organ-sparing surgeries can largely preserve sexual functioning, more invasive treatments like partial or total penectomy result in greater declines, with the impact on sexual wellbeing remaining underexplored. Rigorous prospective studies assessing valid and reliable patient reported outcome measures for sexual wellbeing besides sexual functioning are needed in order to fully understand and address the impact of penile cancer treatment on sexual health.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of sleep quality and chronotype on self-reported erectile function in young adults presenting with erectile complaints: a prospective observational study.","authors":"Ali Nebioğlu, Mert Başaranoğlu, Selahittin Çayan","doi":"10.1038/s41443-025-01089-4","DOIUrl":"https://doi.org/10.1038/s41443-025-01089-4","url":null,"abstract":"<p><p>Erectile complaints are prevalent among young adults, with various factors potentially affecting sexual function and quality of life. This study investigates the impact of sleep quality and chronotype on erectile function in young adults who present with self-reported erectile difficulties. In this prospective study, 249 men with ED were included, assessed from January 2023 to July 2024. Sociodemographic and clinical data were collected for all participants, including age, body mass index (BMI), comorbid diseases, and hormonal parameters. All patients completed the following questionnaires: International Index of Erectile Function (IIEF-5), Pittsburgh Sleep Quality Index (PSQI), Morningness-Eveningness Questionnaire (MEQ), Depression Anxiety Stress Scales-42 (DASS-42), and General Health Questionnaire-28 (GHQ-28). Statistical analyses, including Spearman's correlation and Kruskal-Wallis tests, evaluated the relationships between sleep quality, chronotype, and ED. The average age was 31.03 ± 8.06 years. Significant correlations were found: Poor sleep quality was linked to lower erectile function (r = -0.379, p < 0.001), while morning chronotype correlated with better erectile function (r = 0.424, p < 0.001). Regression analysis confirmed these as significant predictors of ED (R<sup>2</sup> = 0.200, p < 0.001). Sleep quality and chronotype are crucial factors in ED management, suggesting targeted interventions could be beneficial.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Global prevalence of erectile dysfunction in 2025: a call for updated epidemiological data.","authors":"Gang Chen","doi":"10.1038/s41443-025-01094-7","DOIUrl":"https://doi.org/10.1038/s41443-025-01094-7","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"\"Rare sexual disorders\": shedding light on the unspoken spectrum of male sexual health.","authors":"Murat Gül","doi":"10.1038/s41443-025-01090-x","DOIUrl":"https://doi.org/10.1038/s41443-025-01090-x","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rare but real: clinical insights and take-home messages from the special issue on rare male sexual disorders.","authors":"Murat Gül, Suks Minhas","doi":"10.1038/s41443-025-01091-w","DOIUrl":"https://doi.org/10.1038/s41443-025-01091-w","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anthony Bettencourt, Jordan Wu, Joseph A Borrell, Thiago P Furtado, Jesse N Mills, Rajiv Jayadevan, Sriram V Eleswarapu
{"title":"Ejaculatory function after robotic waterjet ablation for the treatment of benign prostatic hyperplasia: a systematic review.","authors":"Anthony Bettencourt, Jordan Wu, Joseph A Borrell, Thiago P Furtado, Jesse N Mills, Rajiv Jayadevan, Sriram V Eleswarapu","doi":"10.1038/s41443-025-01087-6","DOIUrl":"https://doi.org/10.1038/s41443-025-01087-6","url":null,"abstract":"<p><p>Robotic waterjet ablation (RWJA), known by the trade name of Aquablation, is a minimally invasive, heat-free technique for treating benign prostatic hyperplasia (BPH) that offers comparable efficacy to transurethral resection of the prostate (TURP). Unlike TURP, RWJA utilizes targeted tissue mapping, potentially enhancing the preservation of sexual function, particularly antegrade ejaculation. This systematic review evaluated sexual outcomes following RWJA, emphasizing ejaculatory dysfunction and antegrade ejaculation preservation. A literature search conducted through January 1, 2025, in PubMed, Embase, and Cochrane databases identified 15 studies involving 1533 patients. Preservation rates of antegrade ejaculation post-RWJA ranged from 72 to 99.6%. Erectile function remained stable across all reviewed studies. Notably, a randomized controlled trial comparing RWJA to TURP demonstrated significantly lower rates of ejaculatory dysfunction in the RWJA group, maintained for up to five years. Despite promising findings indicating durable preservation of ejaculatory function, there remain limitations due to a scarcity of randomized controlled trials and limited long-term follow-up beyond 12 months. Future comparative studies evaluating RWJA against other minimally invasive BPH treatments are needed to further validate these findings and better define the sexual function outcomes associated with this innovative procedure.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sally Suharyani, Bella Amanda, Jesselyn Angellee, William William, Timotius Ivan Hariyanto, Reny I'tishom
{"title":"Tribulus terrestris for management of patients with erectile dysfunction: a systematic review and meta-analysis of randomized trials.","authors":"Sally Suharyani, Bella Amanda, Jesselyn Angellee, William William, Timotius Ivan Hariyanto, Reny I'tishom","doi":"10.1038/s41443-025-01086-7","DOIUrl":"https://doi.org/10.1038/s41443-025-01086-7","url":null,"abstract":"<p><p>Tribulus terrestris is a medicinal herb purported to enhance reproductive function, particularly in instances of erectile dysfunction (ED). This study aims to assess the effectiveness and safety of administering Tribulus terrestris to patients with ED. We performed a systematic literature review in the Cochrane Library, Medline, Scopus, and Europe PMC databases utilizing particular keywords. The primary endpoint in this study is International Index of Erectile Function, that may be in abridged form (IIEF-5) or full form (IIEF-15). The outcomes of continuous variables were aggregated into the mean difference (MD) with corresponding 95% confidence intervals (95% CI) utilizing random-effects models. Eight studies were selected for inclusion. After the intervention with Tribulus terrestris, the IIEF-5 [MD 4.21, p < 0.00001] and IIEF-15 scores [MD 15.88, p = 0.0004] were markedly elevated compared to their pre-supplementation levels, as per our comprehensive analysis. Additionally, on both the IIEF-5 [MD 3.23 (95%CI 1.89, 4.58), p < 0.00001] and IIEF-15 [MD 14.44 (95%CI 5.75, 23.14), p = 0.001], Tribulus terrestris outperformed placebo. However, the two groups were not significantly different in terms of total testosterone levels. We observed no difference in the incidence of adverse events between Tribulus terrestris and placebo. Tribulus terrestris supplementation may offer benefits in improving erectile function among patients with ED with a relatively good safety profile.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Samuel Ivan, Jessica Pryor, Fenizia Maffucci, Jay Simhan
{"title":"Reservoir placement options: a state of the art review.","authors":"Samuel Ivan, Jessica Pryor, Fenizia Maffucci, Jay Simhan","doi":"10.1038/s41443-025-01082-x","DOIUrl":"https://doi.org/10.1038/s41443-025-01082-x","url":null,"abstract":"<p><p>Reservoir placement for the inflatable penile prosthesis has evolved over time with surgical safety and functional outcomes driving innovative changes. This state of the art review describes contemporary placement options for the inflatable penile prosthesis reservoir, including traditional space of Retzius placement and other alternate reservoir placements. The space of Retzius remains a familiar location for virgin placements while submuscular placement has gained popularity for its versatility and lower risk of visceral injury. The lateral retroperitoneal location can be considered for a patient with a hostile pelvis. A comparison of complications and functional outcomes highlights benefits and drawbacks of each location. This review aims to equip the prosthetic urologist with modern techniques and a surgical armamentarium that can address any reservoir placement.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
John B Smith, Jose Quesada-Olarte, Ervin Kocjancic, Omer Acar
{"title":"A small case series on the use of decellularized cadaveric dermal allograft (DermaPure®) for revisions following gender-affirming vaginoplasty.","authors":"John B Smith, Jose Quesada-Olarte, Ervin Kocjancic, Omer Acar","doi":"10.1038/s41443-025-01088-5","DOIUrl":"https://doi.org/10.1038/s41443-025-01088-5","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}