International Journal of Impotence Research最新文献

{"title":"Comment on: GLP-1 receptor agonists and male sexual health: translating cardiometabolic benefits into erectile outcomes.","authors":"Nicholas Sellke, Michael L Eisenberg","doi":"10.1038/s41443-026-01325-5","DOIUrl":"https://doi.org/10.1038/s41443-026-01325-5","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Quality assessment of artificial intelligence responses in erectile dysfunction: a comparative study based on EAU recommendations.","authors":"Mohamed Eldaneen, Karl H Pang","doi":"10.1038/s41443-026-01375-9","DOIUrl":"https://doi.org/10.1038/s41443-026-01375-9","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative fever with incidental Epstein-Barr virus reactivation after complex penile prosthesis reimplantation.","authors":"Matteo Covre, Michele Rizzo, Venera Costantino, Arianna Biasatti, Massimo Capone, Paolo Umari, Giovanni Liguori","doi":"10.1038/s41443-026-01380-y","DOIUrl":"https://doi.org/10.1038/s41443-026-01380-y","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to establish a prosthetic urology center of excellence.","authors":"Koenraad van Renterghem","doi":"10.1038/s41443-026-01367-9","DOIUrl":"https://doi.org/10.1038/s41443-026-01367-9","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The outcomes of non-surgical and surgical penile augmentation procedures: a systematic review and meta-analysis.","authors":"Lee Smith, Lucille Ridgell, José Francisco López-Gil, Damiano Pizzol, Masoud Rahmati, Nicola Veronese, Tom S Decates, Dong Keon Yon, Jiseung Kang, Eric W Anderson, Bassel H Al Wattars, Barbara Pierscionek, Julia Gawronska, Sherif Wakil, Burak Onal, Ege Can Serefoglu, Angelica Stellato, Roshan Ravindran, Petre Cristian Ilie","doi":"10.1038/s41443-026-01373-x","DOIUrl":"https://doi.org/10.1038/s41443-026-01373-x","url":null,"abstract":"<p><p>Despite the growing popularity of penile augmentation procedures, evidence on benefits and risks across techniques remains limited. This systematic review and meta-analysis aimed to evaluate changes in penile dimensions and adverse events following penile augmentation procedures. Five databases (PubMed, PsycINFO, CINAHL, Web of Science, and Embase) were searched from inception to 16 September 2025, following PRISMA and MOOSE reporting standards. Random-effects meta-analyses were performed using restricted maximum likelihood estimation. Pooled mean differences are reported with 95% confidence intervals and 95% prediction intervals. Thirty studies comprising 2554 participants were included. Given extreme between-study heterogeneity, inference for girth was based primarily on technique-specific estimates. Penile girth increased after non-autologous injectable fillers by a pooled mean of 1.88 cm (95% CI 1.53-2.23; 95% prediction interval 0.27-3.49; k = 18; I² = 100%) and after autologous surgical grafts by a pooled mean of 1.99 cm (95% CI 0.90-3.08; 95% prediction interval -1.73-5.70; k = 5; I² = 99.2%). An exploratory overall girth estimate pooling all techniques was 1.86 cm (95% CI 1.55-2.17; 95% prediction interval 0.13-3.59; k = 29; I² = 100%). Flaccid penile length increased by a pooled mean of 2.20 cm (95% CI 1.79-2.61; 95% prediction interval 0.93-3.46; k = 7; I² = 81.7%). Erect penile length increased by a pooled mean of 1.36 cm (95% CI 0.18-2.53; 95% prediction interval -2.58-5.30; k = 4; I² = 92.3%). Prediction intervals, not pooled means, should guide expectations for a future patient. Magnitude and safety differ by modality. Prospective studies with standardised measurement, validated patient-reported outcomes, and consistent complication grading are required.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: predicting sperm retrieval success in salvage testicular sperm extraction: a machine learning perspective.","authors":"Massimiliano Raffo, Edoardo Pozzi, Fausto Negri, Marco Falcone, Francesco Montorsi, Andrea Salonia","doi":"10.1038/s41443-026-01378-6","DOIUrl":"https://doi.org/10.1038/s41443-026-01378-6","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149207009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring extracts from Wendlandia Uvariifolia Subsp. Chinensis (Merr.) Cowan as natural phosphodiesterase type 5 inhibitors with preclinical anti-erectile dysfunction activity.","authors":"Wenhui Gu, Lingyu Wu, Zhiguo Yang, Zhongbin Cheng, Wenwen Liu, Yi-You Huang, Dan Liu, Faliang An, Jian Li, Qian Zhou, Baoli Li, Hai-Bin Luo","doi":"10.1038/s41443-026-01363-z","DOIUrl":"https://doi.org/10.1038/s41443-026-01363-z","url":null,"abstract":"<p><p>Wendlandia uvariifolia subsp. chinensis (Merr.) Cowan is a traditional medicinal plant used by the Li ethnic group in Hainan Province, China, for the treatment of herpes zoster. However, its pharmacological properties remain unclear. This study aimed to evaluate its phosphodiesterase type 5 inhibitory activity, identify the active components, and explore its therapeutic potential for erectile dysfunction. Through high-throughput screening of 1200 traditional Chinese herbal medicines, this plant was identified as a potential phosphodiesterase type 5 inhibitor. Bioactivity-guided fractionation and gas chromatography-mass spectrometry analysis identified the petroleum ether fraction as the most active fraction, while phytol, one of its identified constituents, inhibited phosphodiesterase type 5 in vitro with an IC₅₀ value of 2.5 ± 0.1 μmol/L. In H₂O₂-injured endothelial cells, petroleum ether fraction significantly restored nitric oxide production. In a paroxetine-induced erectile dysfunction rat model, the fraction improved sexual behavior parameters, restored NO/cGMP signaling, and alleviated pathological remodeling and fibrosis in the corpus cavernosum. In a diabetes mellitus-associated erectile dysfunction rat model, the fraction also improved corpus cavernosum architecture, increased smooth muscle content, and reduced fibrosis, although the increase in the intracavernous pressure/mean arterial pressure ratio did not reach statistical significance. Overall, the results suggest the preclinical anti-erectile dysfunction potential of petroleum ether fraction and support its further mechanistic, pharmacokinetic, safety, and translational evaluation.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149193379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient satisfaction after penile prosthesis implantation in men aged ≥80 years: a single-center retrospective descriptive study.","authors":"Ahmed Al Saeedi, Onder Canguven, Khalid AlKubaisi","doi":"10.1038/s41443-026-01371-z","DOIUrl":"https://doi.org/10.1038/s41443-026-01371-z","url":null,"abstract":"<p><p>Penile prosthesis implantation is an established treatment for medically refractory erectile dysfunction, but patient-reported outcomes in men aged ≥80 years remain underexplored. This retrospective single-center study descriptively evaluated satisfaction, functional device use, and postoperative complications among men aged ≥80 years who underwent penile prosthesis implantation between January 2015 and September 2025. Patients aged 75-79 years were included only to provide clinical context rather than to establish comparative equivalence. Satisfaction was assessed during in-person follow-up using a single non-validated 5-point ordinal item. Among 36 included patients, 13 were aged ≥80 years and 23 were aged 75-79 years. In the ≥80-year group, mean satisfaction was 4.54 ± 1.13, median satisfaction was 5.0 (interquartile range 5.0-5.0), 10 of 13 patients (76.9%) selected the maximum score, 11 of 13 (84.6%) reported full functional use, and 3 of 13 (23.1%) experienced any recorded complication. Contextual between-group estimates were imprecise: the mean satisfaction difference was -0.24 points (95% confidence interval -0.95 to 0.47), and the risk difference for maximum satisfaction was -5.7 percentage points (95% confidence interval -34.8 to 19.0). The clustering of scores at 5 indicates a substantial ceiling effect that limits discrimination by the satisfaction item. Selected men aged ≥80 years reported favorable satisfaction and functional use; however, the small, selected cohort, short and variable follow-up, non-validated single-item measure, and wide confidence intervals preclude conclusions regarding equivalence or broader effectiveness.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Top ten surgical tricks: infrapubic inflatable penile prothesis implantation.","authors":"Edoardo Pozzi, Paolo Capogrosso, Federico Dehò, Francesco Montorsi, Paul Perito, Gabriele Antonini","doi":"10.1038/s41443-026-01370-0","DOIUrl":"https://doi.org/10.1038/s41443-026-01370-0","url":null,"abstract":"<p><p>The infrapubic penile prosthesis implantation approach represents a surgical variant to the traditional penoscrotal approach, characterized by a distinctive incision site used to maintain excellent surgical exposure for a penile prosthesis implantation. Its peculiar features include short operative time, minimally invasive nature, low-reported infection rate, and a direct line of sight for reservoir placement; its specific technical challenges include preservation of the dorsal neurovascular bundle, a restricted working space, and a non-negligible learning curve. In the present manuscript, we describe ten surgical tips covering patient selection and positioning, incision placement, fascial dissection, corporotomy and corporal dilation, reservoir dissection and placement, scrotal pump positioning, hemostasis and drain management, intra-operative device testing, tubing routing, and postoperative care. Each tip is supported, where available, by published evidence and is otherwise drawn from surgical experience.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The evolving landscape of prosthetic urology: a special issue overview.","authors":"Daniar Osmonov","doi":"10.1038/s41443-026-01360-2","DOIUrl":"https://doi.org/10.1038/s41443-026-01360-2","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149136511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}