International Journal of Impotence Research最新文献

Comment on: Meeting the growing demand: an operational blueprint for a 1500-case-per-year penile implant center of excellence. 点评：满足日益增长的需求：一个每年1500例阴茎植入的卓越中心的运营蓝图。

IF 2.5 3区医学

International Journal of Impotence Research Pub Date : 2026-05-04 DOI: 10.1038/s41443-026-01280-1

Steven K Wilson, Ahmet Tevfik Albayrak, Wasim Ghani

引用次数: 0

Quality and readability of online penile-cancer information: a Cross-Sectional Web Study. 在线阴茎癌信息的质量和可读性：一项横断面网络研究。

IF 2.5 3区医学

International Journal of Impotence Research Pub Date : 2026-04-29 DOI: 10.1038/s41443-026-01281-0

Juncheng Ma, Ming Wang, Qiushi Liu, Zihang Chen, Renliang Li, Yuxi Huang, Xiansheng Zhang

{"title":"Quality and readability of online penile-cancer information: a Cross-Sectional Web Study.","authors":"Juncheng Ma, Ming Wang, Qiushi Liu, Zihang Chen, Renliang Li, Yuxi Huang, Xiansheng Zhang","doi":"10.1038/s41443-026-01281-0","DOIUrl":"https://doi.org/10.1038/s41443-026-01281-0","url":null,"abstract":"Penile cancer is rare, and patients increasingly rely on the internet for health information. On April 1, 2025, we conducted a cross-sectional evaluation of the quality and readability of the top 100 Google search results; 71 websites were included in the analysis. Overall quality was fair, with a mean DISCERN score of 41.01 ± 13.67, and transparency was limited, with a mean Journal of the American Medical Association (JAMA) benchmark score of 1.69 ± 1.02. Readability was generally suboptimal: the mean Flesch Reading Ease (FRE) score was 52.06 ± 12.05 (fairly difficult), and the Gunning Fog Index and Simplified Measure of Gobbledygook (SMOG) scores (8.48 ± 2.43 and 7.19 ± 2.02, respectively) indicated reading demands above the recommended sixth-grade level. Kruskal-Wallis and Dunn's post hoc tests showed significant differences in DISCERN scores across affiliations, with non-profit websites scoring higher than commercial websites. FRE also differed by affiliation (p = 0.016), although post hoc comparisons were not significant, and sensitivity analyses supported the robustness of these findings. Correlation analysis demonstrated a strong association between DISCERN and JAMA scores (r = 0.662; p < 0.001). These findings support improved disclosure of authorship and update dates and simplification of language for patient education.","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to Comment on: The outcomes of inflatable penile prosthesis implantation in the context of genital gender affirming surgery in assigned female at birth patients: a comparative study between cis-male dacron modified and Zephyr surgical implants 475 female to male penile prosthesis 性别确认手术背景下女性出生患者充气阴茎假体植入的效果：顺式男性涤纶改良和Zephyr手术假体的比较研究475名女性与男性阴茎假体

IF 2.5 3区医学

International Journal of Impotence Research Pub Date : 2026-04-28 DOI: 10.1038/s41443-026-01276-x

Lorenzo Cirigliano, Marco Falcone

引用次数: 0

Correction: Prostatic and pelvic imaging parameters to predict post radical prostatectomy erectile function recovery: a systematic review. 纠正：前列腺和盆腔成像参数预测根治性前列腺切除术后勃起功能恢复：系统回顾。

IF 2.5 3区医学

International Journal of Impotence Research Pub Date : 2026-04-27 DOI: 10.1038/s41443-025-01107-5

Abdullah Al-Mitwalli, Kayhan Tarim, Mudassir Wani, Louise Dickinson, Wai Gin Lee, David Ralph, Zafer Tandogdu

引用次数: 0

Soy isoflavone supplementation and sexual function in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials. 大豆异黄酮补充剂对绝经后妇女性功能的影响：一项随机对照试验的系统回顾和荟萃分析。

IF 2.5 3区医学

International Journal of Impotence Research Pub Date : 2026-04-24 DOI: 10.1038/s41443-026-01278-9

Aysu Yildiz Karaahmet, Elham Sadeghi

{"title":"Soy isoflavone supplementation and sexual function in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials.","authors":"Aysu Yildiz Karaahmet, Elham Sadeghi","doi":"10.1038/s41443-026-01278-9","DOIUrl":"https://doi.org/10.1038/s41443-026-01278-9","url":null,"abstract":"Postmenopausal women often experience sexual dysfunction (e.g., vaginal dryness, dyspareunia) due to estrogen decline. While hormone replacement therapy (HRT) is effective, safety concerns have spurred interest in alternatives like soy isoflavones. This meta-analysis evaluated soy isoflavones' efficacy for sexual function and menopausal symptoms. We systematically searched PubMed, Cochrane, Scopus, and Web of Science through May 2025 per PRISMA guidelines, identifying 13 RCTs (n = 1325) comparing soy isoflavones (40-160 mg/day) with placebo/HRT. Outcomes included Menopause Rating Scale (MRS) scores. Risk of bias (Cochrane ROB-2) and heterogeneity (I²) were assessed. Soy isoflavones significantly improved vaginal dryness (SMD = - 1.88; 95% CI: -3.24 to -0.53; p = 0.006) and urogenital symptoms (SMD = - 0.33; 95% CI: -0.64 to -0.02; p = 0.04), with non-significant trends for vasomotor (p = 0.08) and psychological symptoms (p = 0.06). Effects were dose-dependent (optimal at 50-100 mg/day) and more pronounced in Asian populations. High heterogeneity (I² > 90%) reflected variability in study designs. Soy isoflavones appear safe and moderately effective for urogenital and sexual symptoms, though further standardized trials are needed to confirm long-term benefits.","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effects of panax ginseng against bisphenol a-induced testicular toxicity in rats. 人参对双酚a致大鼠睾丸毒性的保护作用。

IF 2.5 3区医学

International Journal of Impotence Research Pub Date : 2026-04-23 DOI: 10.1038/s41443-026-01277-w

Dogancan Dorucu, Goksel Sener, Seren Ede Pazarbasi, Burcin Irem Abas, Yasemin Cesur, Ozge Cevik, Feriha Ercan, Tarik Emre Sener, Kamil Cam

{"title":"Protective effects of panax ginseng against bisphenol a-induced testicular toxicity in rats.","authors":"Dogancan Dorucu, Goksel Sener, Seren Ede Pazarbasi, Burcin Irem Abas, Yasemin Cesur, Ozge Cevik, Feriha Ercan, Tarik Emre Sener, Kamil Cam","doi":"10.1038/s41443-026-01277-w","DOIUrl":"https://doi.org/10.1038/s41443-026-01277-w","url":null,"abstract":"Bisphenol A (BPA) is an endocrine-disrupting chemical known to cause testicular toxicity through oxidative stress and apoptosis. Panax ginseng (PG) is a natural product with anti-inflammatory effects. This study aimed to evaluate the protective effect of PG against BPA-induced testicular damage in rats. Thirty-two Wistar Albino rats aged 10-12 weeks were divided into four groups: Control, PG, BPA, and BPA + PG. BPA (50 mg/kg/day) and PG (100 mg/kg/day) were orally administered for 6 weeks. BPA significantly increased serum total oxidant status and decreased antioxidant status (p < 0.001, p < 0.001). Also, the levels of superoxide dismutase (an antioxidant enzyme) (p = 0.0005) and androgen receptor-mRNA (an androgen signaling marker) decreased (p = 0.014). However, caspase 3 (an apoptosis marker) (p = 0.0067), 8-hydroxy-2'-deoxyguanosine (a marker of oxidative DNA damage) (p < 0.001), and tumor necrosis factor-α (a proinflammatory cytokine) (p < 0.001) levels increased in testicular tissues. Rats treated with PG showed improvements in all oxidative and inflammatory markers and significantly restored androgen receptor expression. Histopathological examination revealed degeneration in seminiferous tubules and reduced spermatozoa in the BPA group, while the BPA + PG group showed marked improvement. These findings suggest that PG may alleviate oxidative stress-related testicular damage at both molecular and histological levels and may offer insights for future clinical studies.","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes of adult acquired buried penis (AABP) reconstruction: a multicentre cohort study 成人获得性埋藏阴茎（AABP）重建的结果：一项多中心队列研究

IF 2.5 3区医学

International Journal of Impotence Research Pub Date : 2026-04-23 DOI: 10.1038/s41443-026-01269-w

Natalia Plamadeala, Wai Gin Don Lee, Antonio Ruffo, Mirko Preto, Angelo Di Giovanni, Parth Tagdiwala, Fabio Esposito, Paolo Gontero, David Ralph, Marco Falcone

{"title":"Outcomes of adult acquired buried penis (AABP) reconstruction: a multicentre cohort study","authors":"Natalia Plamadeala, Wai Gin Don Lee, Antonio Ruffo, Mirko Preto, Angelo Di Giovanni, Parth Tagdiwala, Fabio Esposito, Paolo Gontero, David Ralph, Marco Falcone","doi":"10.1038/s41443-026-01269-w","DOIUrl":"10.1038/s41443-026-01269-w","url":null,"abstract":"Adult Acquired Buried Penis(AABP) is a debilitating condition often requiring surgical correction. This multicentre retrospective study, the largest of its kind in Europe to date, evaluated outcomes of 204 patients who underwent AABP repair between June 2011 and January 2025, with a median follow-up of 18.0 months(IQR 7.0–46.0). Surgical complexity was classified according to the Pariser system; 70.6% underwent high-complexity procedures(Pariser≥III). Body Mass Index ≥30 kg/m² was the leading etiological factor(45.1%), more prevalent in the high-complexity group(p < 0.001), followed by lichen sclerosus(23.0%), more prevalent in the low-complexity group(p = 0.011) and genital lymphoedema(20.1%). Main presenting complaints included sexual dysfunction(50.5%), aesthetic concerns(40.7%) and urinary problems(36.3%). Skin grafts were used in 44.6% of cases, more often in low-complexity procedures(p < 0.001). The overall complication rate was 27.0%, significantly higher in the high-complexity group(32.6% vs. 13.3%, p = 0.005), with high-complexity surgery independently predicting complications(p = 0.013). Recurrence occurred in 12.7%, with a recurrence-free survival rate of 91.5% and 83.7% at 12 and 24 months, respectively. Hematoma(p < 0.001) was associated with an increased risk of recurrence, whereas higher surgical complexity(p = 0.018) was associated with a reduced risk of recurrence. Postoperative gains included an increase in stretched penile length by 3.0 cm, improved urinary and sexual function(p < 0.001) and high satisfaction rates(86.8%). While high-complexity surgery leads to higher immediate complication rates, the comprehensive surgical approach, when tailored to the patient, offers durable results and significant improvements in function and quality of life.","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":"38 4","pages":"354-362"},"PeriodicalIF":2.5,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41443-026-01269-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health consequences of anabolic steroids: a sexual-medicine perspective. 合成代谢类固醇对健康的影响：性医学的观点。

IF 2.5 3区医学

International Journal of Impotence Research Pub Date : 2026-04-23 DOI: 10.1038/s41443-026-01272-1

Ahmad Majzoub, Onder Canguven

{"title":"Health consequences of anabolic steroids: a sexual-medicine perspective.","authors":"Ahmad Majzoub, Onder Canguven","doi":"10.1038/s41443-026-01272-1","DOIUrl":"https://doi.org/10.1038/s41443-026-01272-1","url":null,"abstract":"Nonmedical anabolic-androgenic steroid (AAS) use is increasingly encountered in sexual medicine practice, often presenting through sexual symptoms or fertility concerns rather than overt systemic illness. This review summarizes the major health consequences of AAS abuse with emphasis on sexual and reproductive sequelae and provides a pragmatic approach to evaluation and recovery after cessation. AAS exposure commonly suppresses the hypothalamo-pituitary-gonadal axis, leading to hypogonadism and hormonal imbalance that may manifest as reduced libido, erectile dysfunction, gynecomastia, and impaired spermatogenesis ranging from severe oligozoospermia to azoospermia. Recovery after discontinuation is heterogeneous: endocrine parameters frequently normalize earlier than semen parameters, and prolonged/high-dose exposure is associated with delayed or incomplete recovery in a clinically meaningful subset. Beyond sexual and reproductive harm, convergent observational evidence supports increased cardiovascular risk (remodeling, dysfunction, and adverse events), hepatic injury (particularly with 17α-alkylated agents), hematologic/prothrombotic changes, tendon pathology, neuropsychiatric symptoms, and dermatologic complications, with risk shaped by dose, duration, and polypharmacy. In the absence of robust randomized trials, management should prioritize AAS cessation and relapse prevention. Clinicians should actively screen for organ-specific sequelae and individualize follow-up based on symptom burden, hormonal status, fertility goals, and time since last exposure, with selective use of pharmacological induction of recovery when clinically appropriate.","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infection prevention strategies in penile prosthesis implantation: a narrative review. 阴茎假体植入术中感染预防策略的综述。

IF 2.5 3区医学

International Journal of Impotence Research Pub Date : 2026-04-22 DOI: 10.1038/s41443-026-01270-3

Pedro Ramos, Simão Abreu, Afonso Morgado, Nuno Tomada

{"title":"Infection prevention strategies in penile prosthesis implantation: a narrative review.","authors":"Pedro Ramos, Simão Abreu, Afonso Morgado, Nuno Tomada","doi":"10.1038/s41443-026-01270-3","DOIUrl":"https://doi.org/10.1038/s41443-026-01270-3","url":null,"abstract":"Infection remains one of the most feared complications of penile prosthesis implantation (PPI), with implications for patient morbidity, psychological burden, and healthcare costs. Although infection rates have declined due to advances in device coatings, surgical techniques and perioperative care, emerging pathogens and antibiotic resistance continue to challenge clinical outcomes. This narrative review explores recent infection-preventing strategies, including antibiotic prophylaxis (APX), across the preoperative, intraoperative, and postoperative phases of PPI. Key themes include comorbidity optimization, urine culture management, and preoperative antiseptic protocols. Intraoperative innovations such as the no-touch technique, targeted irrigation regimens, and antimicrobial-coated implants have shown significant infection reduction. However, evidence for routine postoperative antibiotic use remains inconclusive, and conservative management of infections is limited to select cases. With changing microbial patterns-including increasing fungal and gram-negative organisms-tailored antibiotic approaches and emerging tools like next-generation sequencing may help refine treatment. A multidisciplinary, evidence-based strategy remains essential to further reduce infection rates and optimize patient outcomes in PPI.","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced genital reconstructive surgery: evolving techniques, expanding indications and future directions 先进的生殖器官重建手术：不断发展的技术，扩大适应症和未来的方向

IF 2.5 3区医学

International Journal of Impotence Research Pub Date : 2026-04-21 DOI: 10.1038/s41443-026-01265-0

Marco Falcone

引用次数: 0