{"title":"Response to comment on: protective effects of Panax ginseng against bisphenol A-induced testicular toxicity in rats.","authors":"Dogancan Dorucu, Kamil Cam","doi":"10.1038/s41443-026-01372-y","DOIUrl":"https://doi.org/10.1038/s41443-026-01372-y","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Romeq Bm Giezen, Layana Al Matarneh, Dalia Al Dhamin, Rawan Haroun, Wadad Alameh, Hassan Hamze
{"title":"The impact of microplastics on the human reproductive system: a narrative review.","authors":"Romeq Bm Giezen, Layana Al Matarneh, Dalia Al Dhamin, Rawan Haroun, Wadad Alameh, Hassan Hamze","doi":"10.1038/s41443-026-01374-w","DOIUrl":"https://doi.org/10.1038/s41443-026-01374-w","url":null,"abstract":"<p><p>Microplastics (MPs), plastic particles smaller than 5 mm, are ubiquitous environmental contaminants and have been reported in human blood, placenta, semen, testis, ovarian follicular fluid, and penile tissue. This narrative review examines evidence relevant to reproductive and sexual health, with emphasis on endocrine signaling, oxidative stress, inflammation, and possible multigenerational effects. Human studies currently demonstrate tissue detection and, in cross-sectional semen studies, associations with selected semen parameters; they do not establish causation. In rodents, fish, invertebrates, and in vitro systems, MP exposure has been associated with impaired spermatogenesis and steroidogenesis, ovarian granulosa-cell injury, altered oocyte maturation, placental dysfunction, and reduced erectile function. Evidence concerning pregnancy outcomes and assisted reproductive technology (ART) remains predominantly experimental or hypothetical. The available literature therefore supports biological plausibility and the need for standardized exposure assessment and longitudinal human studies, but not firm clinical risk estimates or causal conclusions.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Edward L Gheiler, Boris V Klopukh, Adam Cohen, Fernando J Bianco
{"title":"Infection outcomes after primary inflatable penile prosthesis implantation in ambulatory and hospital outpatient settings: a single-surgeon descriptive cohort.","authors":"Edward L Gheiler, Boris V Klopukh, Adam Cohen, Fernando J Bianco","doi":"10.1038/s41443-026-01364-y","DOIUrl":"https://doi.org/10.1038/s41443-026-01364-y","url":null,"abstract":"<p><p>Device infection after inflatable penile prosthesis implantation typically mandates explantation and follows 1-3% of primary implants, a central concern as prosthetic surgery migrates to ambulatory surgery centers. We retrospectively studied all primary implantations by one surgeon while the practice operated an ambulatory program (October 2021-February 2024; the ambulatory program ended for non-clinical administrative reasons). Device, systemic prophylaxis, no-touch technique, and incision were identical between the ambulatory center and a contemporaneous hospital outpatient comparison; intraoperative irrigation was concordant between the ambulatory center and its principal hospital comparator but not across all hospital facilities. Device infection was defined as reoperation for infection within 90 days; reoperation at any interval was also screened. Of 547 primary implantations (ambulatory 218; hospital 329), no infections occurred in the ambulatory arm (0.00%, 95% confidence interval 0.00-1.68%); the hospital rate was 0.61% and the overall rate 0.37% (p = 0.52). Assignment to setting was not random, and the covariates ordinarily governing it - American Society of Anesthesiologists class, body mass index, anticoagulation, cardiopulmonary risk - were unavailable, so baseline risk cannot be assumed equal. With two events these data cannot establish non-inferiority or superiority; they characterize outcomes under one standardized protocol in two settings. These preliminary findings suggest that primary inflatable penile prosthesis implantation may be performed in an ambulatory setting without an apparent increase in infection risk when a standardized infection-prevention protocol is adopted; however, larger prospective studies are required.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fausto Negri, Theresa A Zwaschka, Michael L Eisenberg
{"title":"Comment on: Rising vasectomy volume following reversal of federal protections for abortion rights in the United States.","authors":"Fausto Negri, Theresa A Zwaschka, Michael L Eisenberg","doi":"10.1038/s41443-026-01366-w","DOIUrl":"https://doi.org/10.1038/s41443-026-01366-w","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Subcutaneous penile silicone sleeve implants for penile augmentation: a systematic review and meta-analysis.","authors":"Hao Yang, Wenming Xiao, Hongquan Wang, Guoqiang Tang","doi":"10.1038/s41443-026-01368-8","DOIUrl":"https://doi.org/10.1038/s41443-026-01368-8","url":null,"abstract":"<p><p>Subcutaneous silicone penile sleeve implants, including Penuma and Himplant, are used to increase flaccid penile dimensions and for selected reconstructive indications, but the magnitude of dimensional change and complication profile have not been systematically quantified. This systematic review and single-arm meta-analysis evaluated clinical outcomes after Penuma/Himplant implantation. Cohort studies with clearly defined denominators and extractable outcome data were included in the quantitative synthesis, whereas reports addressing special indications or complications were summarized narratively. Twelve publications from 2018 to 2026 met the inclusion criteria, of which four cohort studies were suitable for primary meta-analysis. The pooled mean increase was 3.77 cm in flaccid girth and 2.94 cm in flaccid length. Pooled complication rates were 3.03% for infection, 5.03% for seroma, 5.12% for erosion or implant exposure, 3.53% for revision, and 7.08% for explantation or implant removal. These descriptive findings are limited to flaccid penile dimensions and do not establish comparative effectiveness; data on erect dimensions and patient-reported outcomes were limited, with validated instruments rarely used. Prospective comparative studies using standardized penile measurements, formal psychological assessment, validated outcome instruments, and longer follow-up are required.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniar Osmonov, Tillmann Heinze, Steven K Wilson, Allen Morey, Axel Stuart Merseburger, Marie Christine Roesch, Hendrik Eike Fender, Koenraad van Renterghem, Ahmed Ragheb, Berk Hazir, Thilo Wedel, Marvin Heimke
{"title":"Surgical steps and relevant anatomical landmarks for the implantation of an inflatable penile prosthesis reservoir placed in the retropubic and submuscular abdominal (\"ectopic\") space.","authors":"Daniar Osmonov, Tillmann Heinze, Steven K Wilson, Allen Morey, Axel Stuart Merseburger, Marie Christine Roesch, Hendrik Eike Fender, Koenraad van Renterghem, Ahmed Ragheb, Berk Hazir, Thilo Wedel, Marvin Heimke","doi":"10.1038/s41443-026-01361-1","DOIUrl":"https://doi.org/10.1038/s41443-026-01361-1","url":null,"abstract":"<p><p>Surgical implantation of an inflatable penile prosthesis is considered the gold-standard treatment for severe erectile dysfunction. Reservoir placement is one of the most challenging steps of this procedure and requires knowledge of the related anatomy. To meet these demands, we have established a postgraduate masterclass program on penile prosthesis implantation that identifies the essential anatomical landmarks demonstrated in predissected anatomical specimens and offers a step-by-step surgical training carried out in body donors under tutored guidance. The main focus of this study is the technical application of our didactic and educational approach by providing high-quality descriptive anatomical illustrations. Surgical steps and anatomical structures relevant for reservoir placement in both the retropubic (\"traditional\") and submuscular abdominal (\"ectopic\") spaces are described and visualized. Anatomical dissections were performed by clinical anatomists in close collaboration with high-volume implanters and reconstructive surgeons. This unique cooperation between theoretical and practical disciplines allowed a detailed focus on shared anatomical targets, providing a comprehensive understanding of the key landmarks in the context of reservoir placement. These technical guidelines and anatomical considerations are indispensable prerequisites for minimizing the risk of complications associated with reservoir placement.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on: From fibrosis to restoration: the multimodal 3 Ts protocol for Peyronie's disease.","authors":"Sam Ward","doi":"10.1038/s41443-026-01362-0","DOIUrl":"10.1038/s41443-026-01362-0","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on: History of testosterone therapy through the ages.","authors":"Jakob Adolf","doi":"10.1038/s41443-026-01365-x","DOIUrl":"https://doi.org/10.1038/s41443-026-01365-x","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Zero-touch technique: a new paradigm in penile prosthesis surgery enabled by a sterile genital barrier system.","authors":"Ahmad Shamsodini, Ibrahim Alnadhari","doi":"10.1038/s41443-026-01335-3","DOIUrl":"10.1038/s41443-026-01335-3","url":null,"abstract":"<p><p>Penile prosthesis (PP) implantation remains the most definitive treatment for medication-refractory erectile dysfunction (ED). Despite reductions in infection rates achieved through improved PP coatings, antimicrobial protocols, and refined surgical techniques, PP infection continues to impose clinical and economic burdens. To overcome these intrinsic constraints, we introduce the Zero-Touch Technique (ZTT), a fundamentally new operative paradigm enabled by a purpose-designed sterile genital barrier system. This system consists of an anatomically contoured non-adhesive penile sheath, an adhesive scrotal and suprapubic isolation layer, and lateral anchoring wings that create a 360-degree sealed sterile field. Applied immediately after antiseptic preparation and before incision, the barrier completely isolates the penis and scrotum, allowing all subsequent steps-including exposure, dilation, implantation, pump placement, and device cycling-to occur without contact with hair-bearing genital skin. ZTT has the potential to improve infection prevention in PP surgery and may contribute to establishing a new sterility standard pending further validation.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149080929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marjan Waterloos, Nicolaas Lumen, Carlo Bettocchi, David Ralph
{"title":"Preview of the ESGURS/ESAU meeting, Ghent September 26.","authors":"Marjan Waterloos, Nicolaas Lumen, Carlo Bettocchi, David Ralph","doi":"10.1038/s41443-026-01359-9","DOIUrl":"https://doi.org/10.1038/s41443-026-01359-9","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149016537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}