International Journal of Impotence Research最新文献

{"title":"A small case series on the use of decellularized cadaveric dermal allograft (DermaPure®) for revisions following gender-affirming vaginoplasty.","authors":"John B Smith, Jose Quesada-Olarte, Ervin Kocjancic, Omer Acar","doi":"10.1038/s41443-025-01088-5","DOIUrl":"https://doi.org/10.1038/s41443-025-01088-5","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Female urethral stricture disease: a narrative review on diagnosis, surgical techniques and outcomes.","authors":"Beatrice Turchi, Nicolaas Lumen, Wesley Verla, Marjan Waterloos","doi":"10.1038/s41443-025-01079-6","DOIUrl":"https://doi.org/10.1038/s41443-025-01079-6","url":null,"abstract":"<p><p>Female urethral stricture (FUS) disease is a rare condition occurring in 4-20% of women with refractory LUTS due to bladder outflow obstruction (BOO). Due to the rarity of this condition, standardization of definition as well as diagnostic criteria and treatment outcomes are lacking. A non-systematic review was conducted exploring the available literature on PubMed and EMBASE databases to identify publications related to the management of FUS between January 2019 and June 2024. Overall, 22 studies were identified. Diagnostic work-up appeared heterogeneous among authors: uroflowmetry (UFM), post-voiding residual of urine (PVR), (video-) urodynamic study (UDS), voiding cystourethrogram (VCUG), urethral calibrations (UC) and urethrocystoscopy (UCS) are the mostly employed tests. Primary treatment consists of urethral dilatation (UD) or urethrotomy. A variety of different reconstructive techniques are currently available such as meatoplasty, flap urethroplasty and graft urethroplasty. Outcome measures varied widely among authors. Patient-reported outcomes (PROMs) were assessed, with a focus on sexual function (FSFI), symptoms and QoL (AUA-ss, IPSS, PGI-I, ICIQ-FLUTS, ICIQ-FLUTSsex, ICIQ-S, UDI, SF-36), demonstrating general improvement. Success rates reported in literature appear to fairly agree amongst authors, but the variability of outcome measures reduces the significance of comparisons between studies. Efforts should be put into pursuing a homogeneity of definitions and criteria. PROMs are promisingly being employed in post-surgical evaluation and should be integrated into standardized follow-up protocols.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional and individual care pathways in gender-affirming healthcare for transgender and gender-diverse individuals - results from the ENIGI follow-up study.","authors":"Andreas Koehler, Inga Becker-Hebly, Els Elaut, Baudewijntje Kreukels, Peer Briken, Gunter Heylens, Thomas D Steensma, Timo Nieder","doi":"10.1038/s41443-025-01085-8","DOIUrl":"https://doi.org/10.1038/s41443-025-01085-8","url":null,"abstract":"<p><p>Treatment requests in transgender healthcare are heterogenous and not all transgender and gender-diverse individuals want to undergo the various transition-related medical interventions offered. This study aims to explore demographic and treatment-related predictors associated with different transgender care pathways in a multicenter, multinational clinical setting. In this follow-up study, 539 adult participants from Belgium, Germany, and the Netherlands took part and were categorized as following a 'traditional' care pathway (i.e., undergoing all transition-related interventions), an 'individual' care pathway (i.e. any course of treatment deviating from the traditional pathway), or 'no care' pathway (i.e. not seeking transition-related medical interventions.). We analyzed differences in demographic (e.g., gender identity) and clinical variables (e.g., treatment satisfaction), conducting logistic regression analysis and descriptive subgroup analysis. Participants with a non-binary gender were 6.7 times more likely to follow an individual care pathway, while participants with higher treatment satisfaction were less likely to follow an individual care pathway (Odds Ratio: 0.6). We identified four patterns of individual transgender care pathways, some as a function of the sex assigned at birth. The present study provides valuable insights into demographic and treatment-related predictors associated with different transgender care pathways. Healthcare providers should be aware of individual transgender care pathways and the association with (non)-binary genders to provide tailored transgender healthcare and ensure individualized, high-quality service provision.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial/Ethnic differences in male reproductive health: a systematic review and meta-analysis of semen parameters and hormonal profiles in the United States.","authors":"Hojat Dehghanbanadaki, Bryan Kim, Kiarad Fendereski, Joshua J Horns, Joemy M Ramsay, Masaya Jimbo, Kelli X Gross, Alexander W Pastuszak, James M Hotaling","doi":"10.1038/s41443-025-01084-9","DOIUrl":"https://doi.org/10.1038/s41443-025-01084-9","url":null,"abstract":"<p><p>We conducted systematic review and meta-analysis of differences in semen parameters and reproductive hormones between White, Black, Asian, Hispanic, and non-Hispanic men in the United States. We systematically searched PubMed, Scopus, and Web of Science. Of 2624 studies identified, 25 studies were included for meta-analysis. The pooled analysis revealed that White men compared to Black men had higher sperm concentration of +26.43 million/ml (95%CI = 7.81, 45.05; I² = 98.98%), higher total sperm count of +128.35 million (95%CI = 82.10, 174.60; I² = 98.46%), lower age-adjusted free testosterone of -15.12 pmol/L (95%CI = -29.89, -0.35; I² = 99.55%), lower age-adjusted estradiol of -15.23 pmol/L (95%CI = -27.61, -2.85; I² = 99.96%), and lower age-adjusted SHBG of -1.52 nmol/L (95%CI = -2.60, -0.44; I² = 95.65%). Compared to Asian men, White men had higher age-adjusted estradiol of +0.97 pmol/L (95%CI = 0.81, 1.14; I² = 0%) and Black men had higher SHBG of +2.93 nmol/L (95%CI = 2.63, 3.23; I² = 0%). Hispanic compared to non-Hispanic men had higher sperm concentration of +5.12 million/ml (95%CI = 4.17, 6.06; I² = 60.67%) and higher total motility of +5.28% (95%CI = 0.49, 10.07; I² = 93.11%), lower age-adjusted total testosterone of -0.77 nmol/L (95%CI = -1.22, -0.33; I² = 98.51%), lower age-adjusted estradiol of -12.54 pmol/L (95%CI = -23.26, -1.81; I² = 99.82%), and lower age-adjusted SHBG of -2.08 nmol/L (95%CI = -4.13, -0.02; I² = 99.57%). In conclusion, this meta-analysis found ethnic variations in male reproductive parameters in the United States.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: The effectiveness of electrical stimulation in the treatment of erectile dysfunction: a systematic review of randomized controlled trials.","authors":"Umadhevan Kanapathy, Ranjith Ramasamy","doi":"10.1038/s41443-025-01083-w","DOIUrl":"10.1038/s41443-025-01083-w","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early complications after penile prosthesis surgery: findings from the PHOENIX multicenter registry.","authors":"Koenraad Van Renterghem, Helene De Bruyn, Alvaro Yebes, Ross Calopedos, Federico Deho, Jose Torremadé, Maurizio D'Anna, Carlo Bettocchi, Borja García Gomez, Christien Caris, Wim Witjes, Ignacio Moncada, David Ralph","doi":"10.1038/s41443-025-01080-z","DOIUrl":"https://doi.org/10.1038/s41443-025-01080-z","url":null,"abstract":"<p><p>Erectile dysfunction is a prevalent condition that may impact psychosocial health and quality of life. While various treatment modalities exist, penile prosthesis implantation offers a permanent solution. Surgery, however, carries inherent risks and potential complications. The aim of this study was to determine the incidence and risk factors of early postoperative complications after penile prosthesis surgery in a large, multicenter, prospective, cohort study. Data was analyzed from patients participating in the PHOENIX registry, an international study on penile prosthesis surgery conducted by the EAU Research Foundation. Patients were operated on from November 2021 until august 2024 in 30 centers from 8 countries. Our study was not limited to one device or brand, all available inflatable and malleable devices were eligible for inclusion. Postoperative complications were registered at different time points, up to 2 years post-surgery. For this analysis we studied complications that occurred within 2 weeks after surgery. Data on early complications after penile prosthesis surgery of 1072 patients were analyzed. Median age was 62 (range 24-88) years old at time of surgery. A total of 639 (59.6%) patients received a drain perioperatively. A total of 49 patients (4.6%) reported complications within 2 weeks after surgery. Infection occurred in 4 patients and penoscrotal hematoma occurred in 6 patients within 2 weeks post-surgery. A total of 5 patients underwent early revision surgery. There was no significant effect of diabetes mellitus on development of an early postoperative infection (0.4% vs. 0.4%, p = 1.00). We found no significant impact of drain placement on hematoma development (0.3% vs. 0.3%, p = 0.69). We did find that early hematoma occurred more frequently in low-volume versus high-volume centers (1.3% vs. 0.1%, p = 0.02). This large international study confirms that penile prosthesis surgery is a safe procedure with a low rate of early postoperative complications.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Older age and low testosterone levels are independently associated with kidney stone prevalence in men: results from a large cross-sectional study.","authors":"Jung Yoon Kang, Jun Ho Lee, Yeasol Kwon, In-Chang Cho, Tag Keun Yoo, Dong-Gi Lee, Jun Baek Park, Jae Duck Choi","doi":"10.1038/s41443-025-01081-y","DOIUrl":"https://doi.org/10.1038/s41443-025-01081-y","url":null,"abstract":"<p><p>We aimed to evaluate the relationship between serum testosterone levels and kidney stone prevalence in men. We examined cross-sectional data from 3234 men who participated in a health examination (2010-2020). A full metabolic work-up, including serum testosterone levels, was performed. Combined ultrasonography with KUB radiography was used for stone detection. The participants' median age and testosterone concentration were 53.0 years and 4.7 ng/mL, respectively. A total of 178 men had kidney stones. A cutoff value for determining the presence of kidney stones was a testosterone concentration <3.33 ng/mL ng/mL. After adjusting for confounders, only age and a testosterone concentration <3.33 ng/mL were significantly related to the presence of kidney stones. However, body mass index, blood pressure, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, creatinine, blood urea nitrogen, HbA1c, uric acid, hs-CRP, calcium, aspartate transaminase, alanine aminotransferase, and albumin were not significantly and independently related to kidney stones. The odds ratios (95% confidence intervals) for kidney stones according to age and testosterone concentration <3.33 ng/mL were 1.029 (1.010-1.04) and 1.655 (1.071-2.556), respectively. Our study revealed that the prevalence of kidney stones significantly and independently increased when the serum testosterone was less than 3.33 ng/mL in men.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prostatic and pelvic imaging parameters to predict post radical prostatectomy erectile function recovery: a systematic review.","authors":"Abdullah Al-Mitwalli, Tarim Kayhan, Mudassir Wani, Louise Dickinson, Wai Gin Lee, David Ralph, Zafer Tandogdu","doi":"10.1038/s41443-025-01047-0","DOIUrl":"https://doi.org/10.1038/s41443-025-01047-0","url":null,"abstract":"<p><p>With radical prostatectomy for prostate cancer, there may be associated long-term postoperative sequalae: urinary incontinence and erectile dysfunction (ED). It is important to predict the functional recovery of erections for better patient counselling and timely treatment of ED. This systematic review looks at imaging parameters to predict the recovery of erectile function (EF) after laparoscopic or robotic prostatectomy. A systematic search was performed to capture publications from January 2000 up to December 2023 (PROSPERO; Registrations ID CRD 42022359557). The considered studies applied an imaging parameter obtained by any form of imaging modality and in any operative phase (pre- or intraoperative) to assess the potential impact on EF after surgery. An essential criterion was a formal EF assessment at both baseline and postoperatively, by means of a validated questionnaire. A total of 8 studies met our inclusion criteria. We categorised the studies based on the imaging modality into three groups: MRI (n = 4), diffusion tensor imaging (DTI) (n = 2), and intraoperative ultrasonography (n = 2). Preoperative MRI parameters were, firstly, dynamic contrast enhancement of prostatic tissue measured as ratio of change of contrast from baseline to 120 s (Ratio120) showing weak correlation to postoperative IIEF5 scores (r = 0.31; p = 0.044), and secondly, area of neurovascular bundle (NVB) was a predictor of EF recovery on univariate analysis (odds ratio = 1.30; P = 0.001). Bony pelvic dimensions, prostate surface area, and fascial thickness measured on MRI did not show correlation with EF scores. Two studies using DTI were included, with one showing the change in the number of periprostatic nerve fibres before and after surgery, which also demonstrated a correlation with the change in EF scores (r = 0.35; P < 0.05). While the other study using DTI showed the change direction of the periprostatic nerve fibres before and after surgery measured as a value of functional anistropy, it showed a weak negative correlation to postoperative EF scores on the left (r = -0.66120; p = 0.0006) and right (r = -0.420068; p = 0.0456). Additionally, intraoperative ultrasound assessment of the NVB, such as the number of visible vessels within the NVB, has also been shown to correlate (r = 0.34, p = 0.0001) with postoperative EF. Our systematic review could not identify an imaging parameter strongly correlated with EF recovery. Enhancement of the prostate on mpMRI and intraoperative ultrasound might be worth investigating through better-designed studies. More research is needed to establish which parameters can reliably predict EF post-prostatectomy to best inform the patient and mitigate the risk.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In continuation of \"Top-cited articles in andrology journals from 2013-2022: a bibliometric analysis\".","authors":"Waseem Hassan, Antonia Eliene Duarte","doi":"10.1038/s41443-024-00948-w","DOIUrl":"10.1038/s41443-024-00948-w","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":"409-410"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141491878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual desire and erotic fantasies questionnaire: development and validation of the sexual desire scale (SDEF1).","authors":"Filippo Maria Nimbi, Roberta Galizia, Giacomo Ciocca, Aleša Bratina Zimic, Emmanuele Angelo Jannini, Chiara Simonelli, Renata Tambelli","doi":"10.1038/s41443-024-00942-2","DOIUrl":"10.1038/s41443-024-00942-2","url":null,"abstract":"<p><p>The evolution in conceptualization of sexual desire has stimulated many attempts to measure it. However measures able to assess multiple expressions of desire in all sexual identities are still lacking. The main aim of the present study was to test the psychometric properties of the Sexual Desire and Erotic Fantasies questionnaire - Part 1 Sexual Desire (SDEF1), developed as a sex-positive measure of different sexual desire expressions. The SDEF1 was assessed in 1773 participants from the Italian general population (1105 women, 645 men, and 23 other genders; ranged between 18-78 years old, mean age 29.31 ± 10.35) on an online survey, together with the Sexual Desire Inventory - 2, the International Index of Erectile Function, the Female Sexual Function Index, and the Marlowe-Crowne Social Desirability Scale-Short Form. Results support a factorial structure of six dimensions, including 28 items and accounting for 58.11% of the total variance: sexual desire, negative feelings to sexual desire, autoerotic desire, regular partner desire, attractive person desire, and responsive desire. The confirmatory factorial analysis showed satisfactory indexes (RMSEA = 0.042 [90% CI = 0.039-0.045]; GFI = 0.97; NFI = .96; and CFI = 0.97). Regression coefficients ranged from 0.39 to 0.94 and were all statistically significant (p < 0.001). The SDEF1 showed good psychometric properties such as internal reliability, construct, and discriminant validity, and to differentiate women and men with and without sexual difficulties. Men reported significantly higher levels of desire than women in all areas except for desire for a regular partner, were no gender difference was detected. Desire for autoerotic activity was the factor accounting for more variance explained among genders (11.7%). The SDEF1 could be a useful measure to assess different areas of sexual desire and its use could be recommended for clinical and research purposes.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":"394-406"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141456640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}