International Journal of Impotence Research最新文献_第3页

Oral suspension versus tablet sildenafil for erectile dysfunction: a prospective multicenter comparative study on patient satisfaction. 口服悬浮液与片剂西地那非治疗勃起功能障碍：一项患者满意度的前瞻性多中心比较研究。

IF 2.5 3区医学

International Journal of Impotence Research Pub Date : 2026-04-09 DOI: 10.1038/s41443-026-01264-1

Borja García-Gómez, Manuel Alonso-Isa, Esther García-Rojo, Celeste Manfredi, Javier Romero-Otero

{"title":"Oral suspension versus tablet sildenafil for erectile dysfunction: a prospective multicenter comparative study on patient satisfaction.","authors":"Borja García-Gómez, Manuel Alonso-Isa, Esther García-Rojo, Celeste Manfredi, Javier Romero-Otero","doi":"10.1038/s41443-026-01264-1","DOIUrl":"https://doi.org/10.1038/s41443-026-01264-1","url":null,"abstract":"New formulations of sildenafil, such as oral suspension, may improve onset of action and patient acceptability. This prospective, non-randomized, multicenter observational study compared sildenafil oral suspension (SiSUS) and sildenafil tablets (SiTAB) in treatment-naïve men with erectile dysfunction (ED). Patients from four urology centers in Madrid selected either SiSUS (Bandol®, AspargoLabs Inc., NY, USA) or SiTAB after standardized counseling and received on-demand treatment for eight weeks. Primary outcome was patient satisfaction assessed by the Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) questionnaire; secondary outcomes included changes in the International Index of Erectile Function-Erectile Function (IIEF-15) scores, latency to erection, and adverse events. A total of 133 patients completed the study (SiSUS: 64; SiTAB: 69). Both groups showed significant improvement in IIEF-15 scores (mean ΔIIEF-15: 17.41 ± 12.46 vs. 17.33 ± 15.02; p = 0.977). Median EDITS score was similar for both groups (77.27 vs. 61.36; p = 0.1312), with significantly greater satisfaction for SiSUS in those men ≤65 (77.27 vs 52.27, p = 0.0486). Median and interquartile ranges (IQR) times for latency to erection were shorter in the SiSUS group: 30 (30-45) vs. 60 (50-60) min; p < 0.0001). Adverse events were comparable (26.6 vs. 21.7%; p = 0.6547), with headache being the most frequent for both groups (12.5, vs 10.14%, p = 0.3244). Limitations include the observational, non-randomized design, short follow-up, and baseline differences between groups. Sildenafil oral suspension offers similar efficacy and safety to tablets, with a faster onset and higher satisfaction in younger patients, supporting its role in individualized ED management.","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147645089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

External scrotal drainage during three-piece inflatable penile prosthesis implantation: preliminary observations from a prospective randomized experience. 三片式充气阴茎假体植入术中阴囊外引流：前瞻性随机经验的初步观察。

IF 2.5 3区医学

International Journal of Impotence Research Pub Date : 2026-04-09 DOI: 10.1038/s41443-026-01257-0

Marco Falcone, Mirko Preto, Murat Gül, Ali Şahin, Martina Scavone, Liliana Guadagni, Lorenzo Cirigliano, Ilaria Ferro, Natalia Plamadeala, Emanuele Zupo, Paolo Gontero

引用次数: 0

Comment on: Penile vibratory stimulation as rehabilitation of erectile function following nerve-sparing radical prostatectomy: a quantitative pilot study. 评论：阴茎振动刺激作为保留神经的根治性前列腺切除术后勃起功能的康复：一项定量的初步研究。

IF 2.5 3区医学

International Journal of Impotence Research Pub Date : 2026-04-07 DOI: 10.1038/s41443-026-01250-7

Peter N Tsambarlis

引用次数: 0

What are the mechanisms that enable Radio-Frequency therapy to be effective in managing Erectile Dysfunction? A narrative review. 是什么机制使射频治疗是有效的管理勃起功能障碍？叙述性评论

IF 2.5 3区医学

International Journal of Impotence Research Pub Date : 2026-04-01 DOI: 10.1038/s41443-025-01201-8

Ilan Gruenwald

{"title":"What are the mechanisms that enable Radio-Frequency therapy to be effective in managing Erectile Dysfunction? A narrative review.","authors":"Ilan Gruenwald","doi":"10.1038/s41443-025-01201-8","DOIUrl":"https://doi.org/10.1038/s41443-025-01201-8","url":null,"abstract":"This article examines the potential mechanisms by which radiofrequency (RF) therapy may affect penile tissues, particularly the tunica albuginea (TA), corpus cavernosum, and related structures, based on known RF effects in other tissues. While current data mostly comes from non-penile studies, this review highlights how similar cellular processes in penile tissues associated with erectile dysfunction (ED) could be influenced by RF. RF has shown promise in stimulating collagen regeneration, enhancing blood flow, promoting tissue healing, and reducing oxidative stress. These mechanisms may support smooth muscle relaxation, nerve regeneration, and improve endothelial function - all critical for erectile function. RF-induced vasodilation and improved penile blood flow could increase oxygenation, while collagen restoration may strengthen the TA, supporting the Veno-occlusive Mechanism (VOM) which is essential for erection. In ED, oxidative stress, impaired nitric oxide (NO) synthesis, and protein misfolding lead to dysfunction in the corpora cavernosa. RF may activate protective pathways such as heat shock proteins (HSP's) and the ubiquitin-proteasome system, reducing oxidative damage and enhancing cellular resilience. Though direct evidence on RF's effects in penile tissues is limited, early clinical improvements in erectile function using RF suggest it could offer a non-pharmacological approach for managing ED. This article reviews these mechanisms and outlines RF's potential therapeutic applications for ED.","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147591862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meeting the growing demand: an operational blueprint for a 1500-case-per-year penile implant center of excellence. 满足日益增长的需求：每年1500例阴茎植入卓越中心的运营蓝图。

IF 2.5 3区医学

International Journal of Impotence Research Pub Date : 2026-03-31 DOI: 10.1038/s41443-026-01260-5

Mohammed Hamdan, Mohammad Ghassab Deameh, Amged Sadeq

{"title":"Meeting the growing demand: an operational blueprint for a 1500-case-per-year penile implant center of excellence.","authors":"Mohammed Hamdan, Mohammad Ghassab Deameh, Amged Sadeq","doi":"10.1038/s41443-026-01260-5","DOIUrl":"10.1038/s41443-026-01260-5","url":null,"abstract":"The global demand for inflatable penile prosthesis (IPP) surgery continues to rise, yet little guidance exists on how mature, ultra-high-volume centers sustain efficiency, safety, and workflow at scale. Drawing on the experience of a single-surgeon center that performed more than 1500 primary inflatable penile prosthesis (IPP) implantations, this perspective outlines the operational philosophy and practical architecture that enabled such volume. The model relies on extreme task specialization within a 13-member team, a streamlined triage and consultation pathway, strict pre-operative standardization, and tightly choreographed surgical logistics using two dedicated operating rooms. Long-standing collaboration among team members enables procedure times of approximately 40 min and supports a daily schedule of 7-15 cases. Prospective patient tracking and consistent postoperative protocols contribute to exceptionally low infection and mechanical revision rates. By describing the elements that enable this level of surgical throughput, rather than presenting these practices as a rigid template, this Perspective aims to stimulate discussion on how high-volume principles can be adapted to diverse clinical environments and how procedural specialization may shape the future of prosthetic urology.","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147591828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calculating foreskin surface area based on glans measurements of 143 men using a simplified geometrical model of the foreskin. 使用简化的包皮几何模型，基于143名男性的包皮头测量计算包皮表面积。

IF 2.5 3区医学

International Journal of Impotence Research Pub Date : 2026-03-30 DOI: 10.1038/s41443-026-01255-2

Guido Hegazy, Manasseh Seidenberg, Holger Erb, Joerg Syllwasschy

{"title":"Calculating foreskin surface area based on glans measurements of 143 men using a simplified geometrical model of the foreskin.","authors":"Guido Hegazy, Manasseh Seidenberg, Holger Erb, Joerg Syllwasschy","doi":"10.1038/s41443-026-01255-2","DOIUrl":"https://doi.org/10.1038/s41443-026-01255-2","url":null,"abstract":"Dimensions of male genitalia have received considerable scientific attention, but the foreskin has been largely omitted from these efforts. To calculate the foreskin surface area based on measurements of patients or voluntary study participants, we describe the foreskin in a simplified model as a tube of elastic tissue with a minimum length corresponding to that of the glans, and a minimum diameter corresponding to that of the corona in flaccid or erect state. To apply our model, we re-analysed previously collected data from a study of penile measurements. In this study from 2001, genitalia of 143 men aged 18 - 68 were measured in flaccid and erect state. Participants were recruited from secondary schools and hospitals, and penile measurements were performed once on a single day by a single medical doctor. We used this set of data to calculate the foreskin surface area and added 10% to the raw glans measurements to account for functional tissue elasticity. We found a median surface area of 79.8 cm2 (Q1 = 63.8 cm2, Q3 = 86.6 cm2) and a mean foreskin surface area of 76.2 cm2 ± 18.9 cm2 (Range 37.6 cm2 - 136.8 cm2). We assume that our approximation is rather an underestimation as we did not include the frenulum and foreskin overhang in our calculation. Our re-evaluation of data from an earlier descriptive study using a simplified geometrical model allows an estimation of foreskin surface area, e.g. as a tissue source for reconstructive surgeries. In summary, we present an estimated reference value of 80 cm2 (rounded median value) and a simple calculation model for the male foreskin surface area.","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147581407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Breaking barriers in Men's health: how a free movember screening campaign encouraged men to visit a urologist. 纠正：打破男性健康的障碍：一个免费的十一月筛查活动如何鼓励男性去看泌尿科医生。

IF 2.5 3区医学

International Journal of Impotence Research Pub Date : 2026-03-30 DOI: 10.1038/s41443-026-01256-1

Romeq Bm Giezen, Basheer Basheer, Rawan Haroun, Jessie Nila Magoncia Bagolor, Franzyn Mondejar, Ledio Zeneli, Michael Fakih, Ranjith Ramasamy

引用次数: 0

Comment on: Zero infection protocol in inflatable penile prosthesis surgery: a prospective cohort study using chlorhexidine-alcohol skin preparation and fibrin sealant hemostasis 评论：充气阴茎假体手术中的零感染方案：一项使用氯己定-酒精皮肤制剂和纤维蛋白密封胶止血的前瞻性队列研究。

IF 2.5 3区医学

International Journal of Impotence Research Pub Date : 2026-03-20 DOI: 10.1038/s41443-026-01258-z

Robert J. Valenzuela, Fernanda Saverio-Rodriguez

引用次数: 0

Self-reported variations in ejaculatory latency time in premature ejaculation: insights into contextual and behavioural factors. 早泄中射精潜伏期的自我报告变化：对背景和行为因素的见解。

IF 2.5 3区医学

International Journal of Impotence Research Pub Date : 2026-03-18 DOI: 10.1038/s41443-026-01253-4

Elena Colonnello, Juanhui Ye, Chunlin Wang, Zhuo Jie Liu, Dake Zhu, Andrea Sansone, Emmanuele A Jannini, Yan Zhang

{"title":"Self-reported variations in ejaculatory latency time in premature ejaculation: insights into contextual and behavioural factors.","authors":"Elena Colonnello, Juanhui Ye, Chunlin Wang, Zhuo Jie Liu, Dake Zhu, Andrea Sansone, Emmanuele A Jannini, Yan Zhang","doi":"10.1038/s41443-026-01253-4","DOIUrl":"https://doi.org/10.1038/s41443-026-01253-4","url":null,"abstract":"Intravaginal ejaculation latency time (IELT) is traditionally considered a stable parameter in premature ejaculation (PE), although recent findings suggest that physiological, behavioural and contextual factors may influence it. This cross-sectional study assessed intraindividual variations in self-reported IELT among 119 men with PE, examining the effects of time of day, sexual position, alcohol consumption, condom use and foreplay duration. Participants completed validated questionnaires and provided IELT estimates across multiple conditions. Masturbation latency (MELT) was significantly longer than vaginal IELT (Z = 7.53, p = 3.0 × 10⁻¹⁴). Daily longest and morning IELT were significantly higher than the \"average\" IELT (Z = 4.06, p = 4 × 10⁻⁵; Z = 3.95, p = 8 × 10⁻⁵), whereas the shortest IELT did not differ significantly (Z = -1.26, p = 0.206). No sexual position emerged as significantly more likely to be associated with the longest or shortest IELT, although position-related IELT differences were reported (longest IELT: Z = 4.97, p = 6.7 × 10⁻⁷; shortest IELT: Z = -6.00, p = 2.0 × 10⁻⁹). IELT increased significantly after alcohol consumption (Z = 4.84, p = 1.3 × 10⁻⁶) and condom use (Z = 4.56, p = 5.1 × 10⁻⁶), while foreplay duration showed minimal impact (p = 9.3 × 10⁻⁸). These findings challenge the assumption of IELT as a fixed diagnostic parameter and highlight the influence of contextual and behavioural factors.","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GLP-1 receptor agonists and male sexual health: Translating cardiometabolic benefits into erectile outcomes. GLP-1受体激动剂与男性性健康：将心脏代谢益处转化为勃起结果

IF 2.5 3区医学

International Journal of Impotence Research Pub Date : 2026-03-16 DOI: 10.1038/s41443-026-01254-3

Jarrett Noakes, Marshall Daffner, James T Burns, Alexander K Bishop, Tate Valerio, Lucas Biondi, Syed Sarwar, Rosstin Afsahi

引用次数: 0