Hui Zhang, Chunlin Wang, Dake Zhu, Andrea Sansone, Elena Colonnello, Tommaso B Jannini, Emmanuele A Jannini, Hui Li, Yan Zhang
{"title":"Masturbation grip strength and perceived intravaginal pressure differential are associated with self-estimated intravaginal ejaculation latency time: a retrospective study.","authors":"Hui Zhang, Chunlin Wang, Dake Zhu, Andrea Sansone, Elena Colonnello, Tommaso B Jannini, Emmanuele A Jannini, Hui Li, Yan Zhang","doi":"10.1038/s41443-026-01358-w","DOIUrl":"https://doi.org/10.1038/s41443-026-01358-w","url":null,"abstract":"<p><p>Although masturbation is common, the association between masturbation-related behaviors and self-estimated intravaginal ejaculation latency time (sIELT) has not been studied. This single-centre retrospective study examined associations between sIELT and masturbatory parameters in 470 male clinic attendees (January 2020-March 2022). sIELT was dichotomised as ≤3 vs >3 min (n = 322 vs 148). Masturbatory grip strength and perceived intravaginal pressure were quantified with a blood-pressure cuff (mmHg; three trials averaged); their differential (G-I) was derived. Hand position was pre-specified as P1-P2 (glans-dominant), P3-P5 (shaft-dominant), or P1-P5 (full-length). The primary analysis used multivariable logistic regression adjusting for age and body mass index (BMI); exploratory sensitivity analyses are reported in the Supplementary Appendix. Compared with the ≤3-min group, the >3-min group had higher G-I (median 5.5 vs 0 mmHg; p < 0.001). Group differences were not significant for grip strength (p = 0.06), perceived intravaginal pressure (p = 0.06), monthly frequency (p = 0.58), duration (p = 0.31), or age at onset (p = 0.05). Shaft-dominant masturbation was more frequent in the >3-min group (55.4 vs 31.4%; p < 0.001) and full-length less frequent (32.4 vs 49.7%; p < 0.001). In multivariable logistic regression adjusted for age and BMI, each 10-mmHg increase in G-I was associated with higher odds of sIELT >3 min (adjusted OR 1.27, 95% CI 1.11-1.44; p < 0.001), and shaft-dominant masturbation was associated with higher odds of sIELT >3 min than full-length masturbation (adjusted OR 2.76, 95% CI 1.77-4.30; p < 0.001). Sensitivity analyses supported the robustness of the main findings; conclusions remain regression-based.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149016549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michelle Leach, Vi Nguyen, Darshan Patel, Tung-Chin Hsieh
{"title":"Male contraception: a historical analysis of the condom, vasectomy, and future innovations.","authors":"Michelle Leach, Vi Nguyen, Darshan Patel, Tung-Chin Hsieh","doi":"10.1038/s41443-026-01354-0","DOIUrl":"https://doi.org/10.1038/s41443-026-01354-0","url":null,"abstract":"<p><p>Male contraception has been utilized for thousands of years and has included abstinence, withdrawal or coitus interruptus, condom usage, and vasectomy. With a rapidly changing reproductive health landscape, there is continued interest and an acute need for new and innovative forms of male contraception. This manuscript aims to look at the history of male contraception as currently used today and to look at future applications. Peer-reviewed and lay literature was examined to discuss the history and to examine the future directions of the field. Barrier male contraception was first recorded in history in 3000 B.C with the use of animal-based penile sheaths in Crete. Charles Goodyear's invention of rubber vulcanization during the Industrial Revolution enabled the mass production of more durable rubber condoms, which were later refined with the introduction of latex in the 1920s. Vasectomy was first explored for use in the treatment of lower urinary tract symptoms of benign prostatic hyperplasia prior to its modern use as contraception. The history of vasectomy is complex, as it was misused in eugenic programs in the United States and other countries during the 19th and 20th centuries. These involuntary sterilization programs, aimed at preventing individuals deemed \"undesirable\" from procreating, were eventually outlawed. Voluntary vasectomy has been a mainstay of permanent male contraception in modern history for decades. Ongoing research continues into novel therapies for male contraception, including both hormonal and non-hormonal methods. With continued interest in providing men with safe and effective forms of contraception, continued research into novel therapies is of the utmost importance.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148968044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carlos A Garcia-Becerra, Maria I Arias-Gallardo, Jesus E Juarez-Garcia, Federico Eskenazi, Juan P Dugarte, Markus A Martinez Holst, Veronica Soltero-Molinar, Natalia Garcia-Becerra, Carlos M Garcia-Gutierrez
{"title":"Response to comment on: cardiovascular and prostate cancer risk associated with testosterone replacement therapy-a systematic review and meta-analysis of 41 randomized controlled trials.","authors":"Carlos A Garcia-Becerra, Maria I Arias-Gallardo, Jesus E Juarez-Garcia, Federico Eskenazi, Juan P Dugarte, Markus A Martinez Holst, Veronica Soltero-Molinar, Natalia Garcia-Becerra, Carlos M Garcia-Gutierrez","doi":"10.1038/s41443-026-01357-x","DOIUrl":"https://doi.org/10.1038/s41443-026-01357-x","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148929523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on: GLP-1 receptor agonists and male sexual health: translating cardiometabolic benefits into erectile outcomes.","authors":"Harrison Smith, Brantley Nelson, Taylor Kohn","doi":"10.1038/s41443-026-01337-1","DOIUrl":"https://doi.org/10.1038/s41443-026-01337-1","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The management of non-infectious complications of penile implant surgery-a narrative review.","authors":"S M Norton, P C Gordon, W G Lee","doi":"10.1038/s41443-026-01353-1","DOIUrl":"https://doi.org/10.1038/s41443-026-01353-1","url":null,"abstract":"<p><p>Penile implant surgery is a well-established treatment for erectile dysfunction. While patient and partner satisfaction rates are high, any non-infectious complication can significantly affect functional outcomes, revision rates and long-term device survival. This narrative review synthesises contemporary evidence on the prevention, recognition and management of non-infectious complications across the pre-operative, intra-operative and post-operative phases of penile implant surgery. A structured search of PubMed from 1980 to 2024 identified 38 relevant articles. Infectious complications were excluded as they represent a distinct clinical entity with separate diagnostic and therapeutic pathways and have been extensively reviewed elsewhere. This narrative review aims to provide a consolidated, practical resource for penile prosthetic surgeons by integrating anatomical considerations, technical pitfalls and evidence-based versus expert-based recommendations with prevention strategies and early recognition of non-infectious complications, the key component in optimizing long-term outcomes.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
William A Langbo, Morgan R Sturgis, Daniel F Roadman, Laurence Levine
{"title":"Perception and Reality of Postoperative Penile Length in Men Undergoing Plaque Excision and Grafting for Peyronie's Disease.","authors":"William A Langbo, Morgan R Sturgis, Daniel F Roadman, Laurence Levine","doi":"10.1038/s41443-026-01352-2","DOIUrl":"https://doi.org/10.1038/s41443-026-01352-2","url":null,"abstract":"<p><p>Partial plaque excision and grafting (PEG) is the gold standard treatment for patients with severe Peyronie's Disease (PD) with preserved erectile function and deformity refractory to conservative management. Post-PEG satisfaction rates are highly variable, with many patients attributing dissatisfaction to penile shortening. We aim to explore patient-reported penile shortening in the pre- and postoperative period. A retrospective chart review and telephone survey was conducted for 137 patients who underwent PEG at a single institution from February 2007 - November 2022. Overall, 75.2% of patients had measured increased or stable stretched penile length (SPL) following PEG, with a mean gain of 1.5 ± 0.9 cm in those who objectively gained length. 75.9% of patients reported preoperative perceived shortening; 46.0% reported postoperative perceived shortening. Perceived preoperative shortening was associated with perceived postoperative shortening (84.1% vs 68.9%, p = 0.03). There was no significant association between perceived postoperative shortening and objective change in SPL (p = 0.38). Subjective postoperative shortening was associated with lower satisfaction rates (38.1% vs 58.1%, p = 0.002) and shorter median follow-up (21 vs 53 months, p = 0.007). Although PEG generally results in SPL gain, managing expectations is critical, with emphasis that the goal of PEG is to achieve functional straightness and rigidity, not necessarily restore penile length lost to PD.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohamed Mubarak, Elia Abou Chawareb, Muhammed A M Hammad, Mohammed Mahdi, Jay Simhan, Faysal A Yafi, Martin Gross, Ian Pearce, Vaibhav Modgil
{"title":"The 50 most-cited primary studies in penile prosthesis surgery: An all-time bibliometric analysis.","authors":"Mohamed Mubarak, Elia Abou Chawareb, Muhammed A M Hammad, Mohammed Mahdi, Jay Simhan, Faysal A Yafi, Martin Gross, Ian Pearce, Vaibhav Modgil","doi":"10.1038/s41443-026-01355-z","DOIUrl":"https://doi.org/10.1038/s41443-026-01355-z","url":null,"abstract":"<p><p>Penile prosthesis (PP) surgery represents a cornerstone intervention for erectile dysfunction (ED). Despite extensive literature, the most-cited primary studies across the full history of the field have not been comprehensively characterized. We aimed to identify and evaluate the 50 most-cited primary studies in PP surgery, describing citation trends, research themes, and academic contributions using bibliometric methods. The Web of Science Core Collection was searched from database inception through 21 April 2025 using predefined PP-related terms. Study design and level of evidence were independently assessed by two reviewers using the Oxford Centre for Evidence-Based Medicine (OCEBM) framework, with disagreements resolved by consensus. The 50 studies (1977-2017) accrued 5652 citations (median, 105; range, 75-215). Most were retrospective observational studies (82.0%) and were assigned Level 4 evidence (56.0%). The Journal of Urology published 28 studies (56.0%). Steven K. Wilson was the most prolific contributor, authoring or co-authoring 10 studies. Non-mutually exclusive themes included surgical outcomes (n = 38), infection (n = 12), and special populations (n = 6). The findings describe the historical development of PP research and highlight the continued need for geographically diverse, prospective, and higher-quality studies.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on: Challenging the paradigm: What is vasculogenic erectile dysfunction? Vasculogenic erectile dysfunction: a continuum perspective.","authors":"Dimitris Hatzichristou","doi":"10.1038/s41443-026-01347-z","DOIUrl":"https://doi.org/10.1038/s41443-026-01347-z","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148828234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to Comment on: Targeting the acute phase of Peyronie's disease: Preliminary experience with Perovial®, a novel hyaluronic acid formulation.","authors":"Massimiliano Raffo, Marco Falcone","doi":"10.1038/s41443-026-01356-y","DOIUrl":"https://doi.org/10.1038/s41443-026-01356-y","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148817943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}