International Journal of Impotence Research最新文献

{"title":"Vasectomy in real-world clinical practice: an ideal checklist to improve patient experience and outcomes.","authors":"Jacob O Rust, Thairo A Pereira, Helen L Bernie","doi":"10.1038/s41443-025-01158-8","DOIUrl":"https://doi.org/10.1038/s41443-025-01158-8","url":null,"abstract":"<p><p>Vasectomy is a highly effective method of permanent contraception for men, offering a minimally invasive and cost-efficient alternative to female sterilization. Over 500,000 vasectomies are performed annually in the U.S., making it the most common non-diagnostic procedure conducted by urologists. Despite this, many residents may not gain adequate training in performing vasectomies in residency, and there are several specific patient populations that warrant additional counseling and care in their approach to a vasectomy. This paper provides a comprehensive review and checklist for the physician detailing necessary steps in the evaluation, counseling, treatment, and management of patients seeking a vasectomy. This includes a focus on special patient scenarios like the young, childless male, the expecting couple, or the individual with intellectual disabilities. Additionally, we review surgical techniques, postoperative care, and reimbursement to ensure a structured, effective approach to vasectomy, while addressing potential challenges that may arise with the goal of optimizing the patient experience and outcomes.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual and urological reconstruction following penectomy for penile cancer: phalloplasty","authors":"Andrea Gobbo,&nbsp;Andrew Nim Christopher,&nbsp;Angelo di Giovanni,&nbsp;Abdullah Al-Mitwalli,&nbsp;Karl Pang,&nbsp;David Ralph,&nbsp;Wai Gin Lee","doi":"10.1038/s41443-025-01161-z","DOIUrl":"10.1038/s41443-025-01161-z","url":null,"abstract":"Phalloplasty following penectomy for penile cancer presents a complex reconstructive challenge, requiring restoration of urinary and sexual function while addressing anatomical and psychological sequelae. Unlike gender-affirming phalloplasty, this procedure is complicated by previous surgery and potential anatomical deficits. However, limited data exist to guide reconstruction in this cohort. This narrative review summarises available evidence on phalloplasty post-penectomy. A systematic search identified six relevant studies, including 48 patients, with follow-up ranging from 1 to 150 months. The radial artery free flap (RAP) and anterolateral thigh flap (ALTP) are the preferred techniques, each with distinct advantages and limitations. While RAP offers superior tactile recovery, ALTP reduces donor site morbidity. Complication rates are high, particularly urethral strictures and fistulae, affecting up to 64.3% of cases. Despite these risks, functional outcomes, including standing micturition and sexual activity, are achievable and patient satisfaction remains high. Challenges include extrapolating data from transgender cohorts and managing psychosocial concerns. A multidisciplinary approach is essential for optimising patient selection, counselling, and long-term outcomes. Further research is needed to refine surgical techniques, improve complication management, and explore innovative reconstructive strategies.","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":"37 9","pages":"745-750"},"PeriodicalIF":2.5,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41443-025-01161-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adipose-derived stem cell therapy restores erectile function and promotes endogenous stem cell recruitment in a rat model of cavernous nerve injury.","authors":"H Y He, S B Duan, B L He, B X Lu, J Q Luo, Z Q Liao, X C Zhou, H B Zhang, A Y Wei, S H He","doi":"10.1038/s41443-025-01162-y","DOIUrl":"https://doi.org/10.1038/s41443-025-01162-y","url":null,"abstract":"<p><p>Erectile dysfunction following non-nerve-sparing prostatectomy is prevalent. Although adipose-derived stem cells (ASCs) have shown therapeutic potential for erectile dysfunction, the underlying mechanisms remain unclear. To investigate the therapeutic effects of exogenous stem cells and their recruitment of endogenous stem cells in the context of postprostatectomy erectile dysfunction, we established a bilateral cavernous nerve injury (BCNI) rat model. The rats were divided into the sham surgery, BCNI + PBS, and BCNI+ASCs groups. Intracavernous pressure/mean arterial pressure ratios were compared between groups. In vivo imaging revealed ASC retention in the corpora cavernosa. Penile histomorphology and smooth muscle content were evaluated via Hematoxylin‒eosin and Masson staining. Immunohistochemistry, western blotting, and immunofluorescence were employed to quantify α-SMA, nNOS, caspase-3, vWF, Bax, Bcl-2, and SDF-1 levels and endogenous stem cell recruitment. Compared with the PBS control group, the ASC-treated group presented increased α-SMA, nNOS, and vWF expression and smooth muscle content, as well as reduced caspase-3, Bax, and Bcl-2 levels. Endogenous stem cell recruitment was observed in ASC-treated rats. Our findings demonstrate that exogenous ASCs injection suppresses apoptosis, enhances endothelial function, recruits endogenous stem cells, and alleviates erectile dysfunction in BCNI models. This study elucidates ASC-mediated mechanisms involved in erectile dysfunction recovery, providing insights for clinical translation.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical approaches for distal urethral strictures after failed hypospadias repair: a systematic review and meta-analysis.","authors":"Vladimir Kojovic, Marko Marjanovic, Predrag Ilic, Ana Cvetinovic, Sava Cvetinovic, Emre Cico","doi":"10.1038/s41443-025-01167-7","DOIUrl":"https://doi.org/10.1038/s41443-025-01167-7","url":null,"abstract":"<p><p>Urethral stricture is a frequent complication following hypospadias repair, often complicated by scarring, anatomical distortion, and poor tissue vascularity. This systematic review and meta-analysis evaluated outcomes of single-stage versus staged urethroplasty for distal urethral strictures after failed hypospadias repair. A total of 20 studies were analyzed. Data were extracted regarding surgical techniques, success rates, complications, and duration of follow-up. Meta-analysis showed a pooled success rate of 78.1% (95% CI: 70.2-84.4%) for single-stage and 76.2% (95% CI: 52.1-90.4%) for staged procedures. The difference in efficacy was not statistically significant. Single-stage repairs were generally associated with shorter treatment durations, while staged approaches were preferred in cases with severe fibrosis or poor tissue quality. Complication rates ranged from 10% to 50%. In staged procedures, the use of buccal mucosa grafts yielded better outcomes compared to skin flaps or other grafts. Significant heterogeneity was observed (I² = 65.2% for single-stage, I² = 90.1% for staged; p < 0.01), likely due to variability in surgical techniques, patient demographics, and follow-up protocols. No publication bias was detected (Egger's test p = 0.398 and 0.388, respectively). Further standardized, prospective studies are necessary to optimize treatment selection and to enhance surgical outcomes.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: A novel rat model for investigating erectile function after nerve-sparing radical prostatectomy.","authors":"Leonidas Karapanos, Ahmet Tevfik Albayrak","doi":"10.1038/s41443-025-01163-x","DOIUrl":"https://doi.org/10.1038/s41443-025-01163-x","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145053111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Removal rate and mechanical failure in penile prosthesis implantation: A systematic review.","authors":"Mattia Lo Re, Marta Pezzoli, Andrea Cocci, Anna Cadenar, Andrea Minervini, Esther Garcia Rojo, Innocent Nzeyimana, Javier Romero Otero, Manuel Alonso Isa, Borja Garcia Gomez","doi":"10.1038/s41443-025-01165-9","DOIUrl":"https://doi.org/10.1038/s41443-025-01165-9","url":null,"abstract":"<p><p>Erectile dysfunction affects around 40% of men and is increasingly prevalent with age and comorbid conditions like cardiovascular disease and depression. Inflatable penile prostheses could be considered one of the definitive treatments for this condition. This systematic review aims to compare the safety and durability of AMS 700® (Boston Scientific), Coloplast Titan® (Coloplast), Rigicon Infla 10® (Rigicon), and Zephyr ZSI 475® (Zephyr) inflatable penile prostheses, focusing on infection rates, removals, and mechanical failures. A systematic review following PRISMA guidelines was conducted. The search identified studies on penile prostheses safety and patient satisfaction. Inclusion criteria were studies on adult males undergoing three-component penile prosthesis implantation for erectile dysfunction reporting data on removal rates, causes, and mechanical failures. Studies on implantation of two-component or malleable penile prosthesis were excluded. After the screening, 30 studies published between 1994 and 2023 were included. The median follow-up duration ranged from 12 to 206 months. Removal rates ranged from 0% to 52.9%, generally below 10%, with infection rates typically under 5%. AMS 700® devices had removal rates from 0.3% to 52.9%, while Coloplast Titan® devices ranged from 0% to 6.2%. Rigicon Infla 10® showed a low mechanical failure rate of 2-3% over short follow-up periods. Zephyr ZSI 475® had high initial mechanical failure rates (25.7%). Mechanical failures varied widely, with AMS® reporting rates from 0 to 37.3%, Coloplast Titan® from 0 to 9.1% but with median shorter follow-up durations. Most inflatable penile prostheses demonstrate good long-term tolerance and durability. While AMS 700® and Coloplast Titan® prostheses are well-established, the low mechanical failure rates of the Rigicon Infla 10®, although promising, need to be confirmed by further studies with a longer follow-up. Preliminary Zephyr® data are inconclusive but highlight the need for further evaluations. Rigorous long-term follow-up and comparative studies are essential to confirm these findings and guide clinical decision-making.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145053155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Depression and Anxiety are Associated with Increased Complications after Penile prosthesis surgery: a retrospective cohort study.","authors":"Ahmet Tevfik Albayrak, Sung Hun Park","doi":"10.1038/s41443-025-01170-y","DOIUrl":"https://doi.org/10.1038/s41443-025-01170-y","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The evolution of penile reconstructive techniques in urology.","authors":"Mehmet Hamza Gultekin, Abdullah Al-Mitwalli, Wai Gin Lee, David Ralph","doi":"10.1038/s41443-025-01141-3","DOIUrl":"https://doi.org/10.1038/s41443-025-01141-3","url":null,"abstract":"<p><p>The need to enhance the quality of life and functionality of patients with a number of diseases, such as congenital abnormalities, traumas, and gender incongruence, has contributed to a significant development in the field of male genital reconstructive surgery. This article highlights the roots of penile reconstructive surgeries over history, emphasizing innovative achievements that have shaped modern practices. Critical advancements that have improved surgical accuracy and post-operative care are examined, including new imaging modalities, penile prosthesis implantation, and complete phallic reconstruction. In terms of future improvements in genital reconstructive surgery, the combination of tissue engineering and microsurgery offers the potential to further improve the field.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incorporating regenerative therapies in the management of erectile dysfunction and Peyronie's disease.","authors":"Zaed Jaber, Iurii Vasilievich Kastrikin, Joanna Ebenezer Jayakumar, Shiney James, Ranjith Ramasamy","doi":"10.1038/s41443-025-01168-6","DOIUrl":"https://doi.org/10.1038/s41443-025-01168-6","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Variations in diagnostic criteria for male hypogonadism: is there a need for standardizing specialist society guidelines?","authors":"Edoardo Pozzi, Ranjith Ramasamy","doi":"10.1038/s41443-025-01164-w","DOIUrl":"https://doi.org/10.1038/s41443-025-01164-w","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}