{"title":"Response to comment on: Pre-spermatorrhea state: a novel therapeutic paradigm for the management of non-organic delayed ejaculation and anejaculation.","authors":"Dawei Gao, Wenxiu Zhang, Chuyu Li, Yihan Jin, Weimin Deng, Dalin Sun, Baofang Jin","doi":"10.1038/s41443-026-01249-0","DOIUrl":"https://doi.org/10.1038/s41443-026-01249-0","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147456997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Novel application of drug-coated balloon in external urethral meatus stricture: urinary and sexual outcomes.","authors":"Mattia Lo Re, Marta Pezzoli, Andrea Cocci","doi":"10.1038/s41443-026-01228-5","DOIUrl":"https://doi.org/10.1038/s41443-026-01228-5","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147457056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexander van Renterghem, Lien Verbeke, Helene De Bruyn, Caroline Jamaer, Evert Baten, Koenraad van Renterghem
{"title":"Response to Comment on: The penoscrotal approach is a viable alternative to the perineal approach for artificial urinary sphincter implantation: A retrospective cohort study.","authors":"Alexander van Renterghem, Lien Verbeke, Helene De Bruyn, Caroline Jamaer, Evert Baten, Koenraad van Renterghem","doi":"10.1038/s41443-026-01248-1","DOIUrl":"https://doi.org/10.1038/s41443-026-01248-1","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147432659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ryan L. Frazier, David W. Barham, Jay Simhan, Faysal A. Yafi, Martin S. Gross
{"title":"Comment on: Zero infection protocol in inflatable penile prosthesis surgery: a prospective cohort study using chlorhexidine-alcohol skin preparation and fibrin sealant hemostasis","authors":"Ryan L. Frazier, David W. Barham, Jay Simhan, Faysal A. Yafi, Martin S. Gross","doi":"10.1038/s41443-026-01244-5","DOIUrl":"10.1038/s41443-026-01244-5","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":"38 4","pages":"372-373"},"PeriodicalIF":2.5,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41443-026-01244-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147344127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to comment on: zero infection protocol in inflatable penile prosthesis Surgery: a prospective cohort study using chlorhexidine-alcohol skin preparation and fibrin sealant hemostasis","authors":"Ali Fathollahi, Shirin Razdan, Sanjay Razdan","doi":"10.1038/s41443-026-01245-4","DOIUrl":"10.1038/s41443-026-01245-4","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":"38 4","pages":"374-375"},"PeriodicalIF":2.5,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41443-026-01245-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147344153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chunlin Wang, Dake Zhu, Andrea Sansone, Elena Colonnello, Erika Limoncin, Daniele Mollaioli, Yan Zhang, Emmanuele A Jannini
{"title":"The Orgasmometer-m: validation in Mandarin and measurement of orgasmic intensity in the Han population affected by premature ejaculation.","authors":"Chunlin Wang, Dake Zhu, Andrea Sansone, Elena Colonnello, Erika Limoncin, Daniele Mollaioli, Yan Zhang, Emmanuele A Jannini","doi":"10.1038/s41443-026-01233-8","DOIUrl":"https://doi.org/10.1038/s41443-026-01233-8","url":null,"abstract":"<p><p>This cross-sectional study aimed to validate the male version of the Orgasmometer in Mandarin and to examine whether Chinese men with premature ejaculation (PE) experience reduced orgasmic intensity. From September 2020 to January 2023, a group of 230 men with PE (mean age=28.2 ± 4.8) and 107 men without sexual dysfunction (mean age= 35.1 ± 6.7), who were seeking help from the Department of Infertility and Sexual Medicine, underwent a detailed assessment from the andrologist and completed a questionnaire that included the Mandarin Orgasmometer (Orgasmometer-m), the Premature Ejaculation Diagnostic Tool (PEDT), and the erectile function domain of the International Index of Erectile Function (IIEF-6). Orgasmometer-m scores were 5.0 (4.0) in the PE group and 8.0 (3.0) in the non-PE group; PEDT scores were 14.8 ± 2.5 and 3.3 ± 2.4, and IIEF-6 scores were 27.9 ± 1.6 and 29.1 ± 1.2, respectively (p < 0.001). The Orgasmometer demonstrated good discriminative validity, with an area under the curve (AUC) of 0.8296 (95% CI: 0.7873-0.8719, p < 0.0001). A score of ≤6 was identified as the optimal cutoff for distinguishing low from high orgasm intensity, yielding 66.1% sensitivity and 86.9% specificity. These findings support the reliability of the Orgasmometer-m and suggest that men with PE report diminished orgasmic experiences.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147305557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The role of sleep stages in the regulation of erectile function: impacts of REM sleep fragmentation.","authors":"Monica Levy Andersen, Sergio Tufik","doi":"10.1038/s41443-026-01240-9","DOIUrl":"https://doi.org/10.1038/s41443-026-01240-9","url":null,"abstract":"<p><p>Erectile function is a complex neurovascular process influenced by multiple physiological systems, including autonomic regulation, vascular integrity, and endocrine balance. Sleep-related erections (SRE), which occurs predominantly during rapid eye movement sleep (REM), plays a critical role in maintaining erectile physiology by ensuring periodic oxygenation of penile tissue and preventing fibrosis. Sleep fragmentation, particularly disruption of REM sleep, has been increasingly recognized as a contributing factor to erectile dysfunction (ED), with mechanisms involving heightened sympathetic activity, impaired parasympathetic vasodilation, and neuroendocrine dysregulation. Sleep disorders, such as obstructive sleep apnea and chronic sleep deprivation are associated with reduced SRE frequency, increased oxidative stress, and decreased nitric oxide bioavailability, all of which contribute to endothelial dysfunction and erectile impairment. Ageing exacerbates these issues by further reducing SRE occurrence and increasing the prevalence of sleep disturbances. Therapeutic strategies aimed at optimizing sleep architecture and its quality, including pharmacological, hormonal, and neuromodulatory interventions, may provide promising avenues for mitigating ED and promoting healthy ageing. This review highlights the interplay between sleep physiology, erectile function, and therapeutic implications, underscoring the importance of sleep optimization in ED management.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147283565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marie Juul-Haslund, Mikkel Fode, Christian Fuglesang S Jensen
{"title":"Comment on: Men with delayed ejaculation report lower sexual satisfaction and more depressive symptoms than those with premature ejaculation: findings from a cross-sectional study.","authors":"Marie Juul-Haslund, Mikkel Fode, Christian Fuglesang S Jensen","doi":"10.1038/s41443-025-01219-y","DOIUrl":"10.1038/s41443-025-01219-y","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Azamjon Makhmudov, Azamjon Tulaboev, David Rowland, Sarvar Aliev
{"title":"Illustration of the perils of relying solely on patient self-identification for the diagnosis of premature ejaculation.","authors":"Azamjon Makhmudov, Azamjon Tulaboev, David Rowland, Sarvar Aliev","doi":"10.1038/s41443-026-01239-2","DOIUrl":"https://doi.org/10.1038/s41443-026-01239-2","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147276017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}