International Journal of Impotence Research最新文献

{"title":"Botulinum toxin a combined with penile traction therapy for the treatment of penile retraction: a retrospective single-arm pilot study.","authors":"Zihao Li, Hailong He, Tao Xu, Xiaowei Zhang","doi":"10.1038/s41443-026-01345-1","DOIUrl":"https://doi.org/10.1038/s41443-026-01345-1","url":null,"abstract":"<p><p>This retrospective single-arm pilot study evaluated a novel minimally invasive approach combining Botulinum Toxin A injection with penile traction therapy for the treatment of penile retraction. This study was conducted in 168 men with retractile penis treated between October 2023 and June 2025. Flaccid penile length was measured in the standing position with the penis in a naturally dependent state after a resting period in a room-temperature environment, using a rigid ruler from the pubic symphysis to the tip of the glans with compression of the suprapubic fat pad. Psychological outcomes were assessed using the Self-Esteem and Relationship questionnaire and the Index of Male Genital Image, while erectile function was evaluated using the five-item International Index of Erectile Function. Mean baseline flaccid penile length was 4.4  ±  0.66 cm, increasing significantly to 6.9  ±  0.81 cm at 6 months (P < 0.001). Improvements were also observed under thermal stimulation and in the penile retraction reduction ratio, which decreased from 27.3-11.6% at 6 months (P < 0.001). Erectile penile length and five-item International Index of Erectile Function scores showed no significant changes. Psychological outcomes improved significantly, with Self-Esteem and Relationship and Index of Male Genital Image scores increasing from 28.8  ±  4.3 and 39.3  ±  5.7-54.4  ±  5.6 and 59.0  ±  7.3, respectively (P < 0.001). Mild transient injection-site pain occurred in 11.3% of patients without other complications. This combined therapy may represent a feasible minimally invasive option for selected patients with penile retraction and reduced visible flaccid penile exposure. However, it does not confer true anatomical penile elongation, and given the exploratory single-arm design, the findings should be interpreted with caution. Further prospective randomized controlled studies using standardized penile measurements and longer follow-up are needed to clarify the durability of treatment effects and the independent contribution of each treatment component.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148758174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: SAPOC technique for length restoration in complex Peyronie's disease and erectile dysfunction at the time of penile prosthesis placement.","authors":"Liliana Guadagni, Marco Falcone","doi":"10.1038/s41443-026-01340-6","DOIUrl":"https://doi.org/10.1038/s41443-026-01340-6","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148712359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: soft glans after penile prosthesis surgery: a patient-reported study of prevalence and clinical impact.","authors":"Çağrı Şevik, Gökhan Çeker, Halil Lutfi Canat","doi":"10.1038/s41443-026-01341-5","DOIUrl":"https://doi.org/10.1038/s41443-026-01341-5","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality assessment of artificial intelligence responses in erectile dysfunction: a comparative study based on EAU recommendations.","authors":"Gökhan Çeker, Afonso Morgado, Giorgio Ivan Russo, Marco Falcone, Esther García Rojo, Celeste Manfredi, Omar Almidani, Rashed Rowaiee","doi":"10.1038/s41443-026-01339-z","DOIUrl":"10.1038/s41443-026-01339-z","url":null,"abstract":"<p><p>Artificial intelligence (AI)-based language models are increasingly explored as tools for interpreting and applying clinical guideline recommendations. In urology, the European Association of Urology (EAU) recently introduced a guideline-specific chatbot; however, its comparative performance relative to contemporary general-purpose large language models (LLMs) remains unclear. In this structured comparative study, five AI systems-the EAU Guidelines Bot, ChatGPT-5, Gemini 2.5 Pro, Copilot - Smart GPT-5, and Perplexity Pro-were evaluated using 13 clinical questions derived directly from strongly recommended statements in the EAU erectile dysfunction (ED) guidelines. Responses were independently assessed by three senior reviewers across five predefined domains: relevance, clarity, structure, clinical utility, and factual accuracy, using a 5-point Likert scale. The primary outcome of the study was the composite performance score, which was calculated as the mean of the five domain scores. Inter-rater reliability was calculated using ICC(2,k), and differences among models were analyzed with the Friedman test followed by Holm-adjusted Wilcoxon post-hoc comparisons. Significant performance differences were observed across all domains (all p < 0.001). The highest composite scores were observed for Gemini 2.5 Pro [4.60 (4.40-4.73)] and the EAU Guidelines Bot [4.53 (4.47-4.80)], followed by ChatGPT-5 [4.27 (4.07-4.47)]. Lower composite scores were observed for Copilot - Smart GPT-5 [3.73 (3.40-3.87)] and Perplexity Pro [3.60 (3.47-3.80)]. Domain-level analysis showed consistently high median scores (≥ 4) for factual accuracy among top-performing models, whereas variability was more pronounced in clarity, structure, and clinical utility. These findings suggest that both guideline-specific systems and advanced general-purpose LLMs may generate responses broadly consistent with guideline-based recommendations in structured ED scenarios. However, variability across domains-particularly in structure and clinical utility-and modest differences in composite performance suggest that these models should be interpreted as supportive tools rather than definitive clinical decision-making systems, requiring further validation in real-world settings.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148689159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Outcomes of adult acquired buried penis (AABP) reconstruction: a multicentre cohort study.","authors":"Josep Torremadé, Alfonso Bruzzone, Maurizio D Anna","doi":"10.1038/s41443-026-01338-0","DOIUrl":"https://doi.org/10.1038/s41443-026-01338-0","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148684443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: protective effects of Panax Ginseng against bisphenol A-induced testicular toxicity in rats.","authors":"Burak Onal, Ilkay Alp Yildirim","doi":"10.1038/s41443-026-01336-2","DOIUrl":"10.1038/s41443-026-01336-2","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148602529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Early complications after penile prosthesis surgery: findings from the PHOENIX multicenter registry.","authors":"Koenraad Van Renterghem, Helene De Bruyn, Alvaro Yebes, Ross Calopedos, Federico Deho, Jose Torremadé, Maurizio D'Anna, Carlo Bettocchi, Borja García Gomez, Christien Caris, Wim Witjes, Ignacio Moncada, David Ralph","doi":"10.1038/s41443-026-01235-6","DOIUrl":"https://doi.org/10.1038/s41443-026-01235-6","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to comment on: penile prosthesis implantation for patients with comorbid severe premature ejaculation and erectile dysfunction: a pilot cohort study.","authors":"Gabriele Antonini, Sara Baldini, Riccardo Terruzzi, Piergiorgio Tuzzolo, Paolo Capogrosso, Alessio Villano, Matteo Coschignano, Ilaria Elena Zais, Nicolò Schifano, Antonio Aversa, Federico Dehò","doi":"10.1038/s41443-026-01334-4","DOIUrl":"https://doi.org/10.1038/s41443-026-01334-4","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: The effect of stress on testosterone and sexual function.","authors":"Andrea Sansone, Elena Colonnello, Emmanuele A Jannini","doi":"10.1038/s41443-026-01330-8","DOIUrl":"https://doi.org/10.1038/s41443-026-01330-8","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Cardiovascular and prostate cancer risk associated to testosterone replacement therapy - a systematic review and meta-analysis of 41 randomized controlled trials.","authors":"Amin Sharifan","doi":"10.1038/s41443-026-01333-5","DOIUrl":"10.1038/s41443-026-01333-5","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}