International Journal of Impotence Research最新文献

{"title":"Seminal vesicles - an overlooked pair of accessory glands in male sexual dysfunction: a narrative review.","authors":"Dawei Gao, Chuyu Li, Yihan Jin, Dalin Sun, Yugui Cui, Weiping Chen, Baofang Jin","doi":"10.1038/s41443-024-01011-4","DOIUrl":"https://doi.org/10.1038/s41443-024-01011-4","url":null,"abstract":"<p><p>The seminal vesicles (SVs) have long been recognized for their role in male fertility, yet their contribution to male sexual function is often underestimated. In recent decades, studies have gradually unveiled an association between SVs and various male sexual dysfunctions (SDs), including diminished libido, erectile dysfunction, premature ejaculation, delayed ejaculation, and orgasmic disorder. We conducted a comprehensive literature search of publications up until April 2024 in PubMed, Google Scholar, and CNKI, focusing on original studies, case reports, and reviews addressing the relationship between SVs and male SDs. The aim was to explore the pathophysiological mechanisms, clinical evaluation, and management of this relationship, providing urologists and andrologists with new insights into diagnosing and treating complex male SDs. Current research suggests that SVs may play a role in male sexual function, but the evidence remains limited. Future large-scale, rigorously designed studies are needed to further validate this relationship.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in penile prosthetics: current trends and future directions in erectile dysfunction treatment","authors":"Wayne J. G. Hellstrom","doi":"10.1038/s41443-024-01010-5","DOIUrl":"10.1038/s41443-024-01010-5","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":"37 1","pages":"1-3"},"PeriodicalIF":2.8,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41443-024-01010-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The assessment and aetiology of drug-induced ischaemic priapism.","authors":"Divyen Moodley, Anja Badenhorst, Yahya Choonara, Ahmed Adam","doi":"10.1038/s41443-024-01006-1","DOIUrl":"https://doi.org/10.1038/s41443-024-01006-1","url":null,"abstract":"<p><p>Ischaemic priapism is a urological emergency characterised by a prolonged, painful erection unrelated to sexual stimulation. While several aetiological factors contribute to this condition, the pharmacological causes have gained significant attention in recent years. This narrative review aims to comprehensively assess ischaemic priapism, specifically focusing on its pharmacological aetiology. We propose an approach and assessment strategy to the numerous factors associated with pharmacologically induced ischaemic priapism. By enhancing our understanding of the pharmacological causes of this condition, healthcare professionals can improve patient management and reduce the long-term complications associated with ischaemic priapism.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are young men attempting to achieve paternity through intracytoplasmic sperm injection candidates for general health screenings?","authors":"Michael Kitlinski, Aleksander Giwercman, Yvonne Lundberg Giwercman, Angel Elenkov","doi":"10.1038/s41443-024-01009-y","DOIUrl":"https://doi.org/10.1038/s41443-024-01009-y","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Does every transgender person want gender affirming surgery? A survey of transgender individuals in the Midwestern United States.","authors":"Gökhan Çeker","doi":"10.1038/s41443-024-01007-0","DOIUrl":"10.1038/s41443-024-01007-0","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between serum homocysteine and erectile dysfunction: a systematic review and meta-analysis.","authors":"Peng Cheng, Hui-Min Li, Ya-Jun Shen, Yun-Wu Wang, Xiao-Lei Tang","doi":"10.1038/s41443-024-00978-4","DOIUrl":"https://doi.org/10.1038/s41443-024-00978-4","url":null,"abstract":"<p><p>The aim of this meta-analysis was to determine the relationship between erectile dysfunction (ED) and serum homocysteine (Hcy) levels. A comprehensive search was performed using databases such as Web of Science, PubMed, and the Cochrane Library to identify suitable studies published by July 2023. The statistical analysis involved calculating the standardized mean differences (SMDs) and 95% confidence intervals (CIs) using STATA software. Twelve studies with 1766 ED patients and 2340 non-ED control participants were included in this meta-analysis. The pooled results indicated that the Hcy levels of ED patients were obviously greater than those of control participants (SMD (95% CI) = 0.97 (0.51,1.43), p < 0.001). Subgroup analysis revealed a greater SMD in ED patients aged>40 years, overweight status, those with a mild-moderate International Index of Erectile function (IIEF) score, and those living in Mediterranean countries, (1.18 (0.61, 1.75), p < 0.001; 1.27 (0.72, 1.82), p < 0.001;1.63 (1.04, 2.22), p < 0.001; 1.18 (0.61, 1.75), p < 0.001, respectively). Our meta-analysis indicated that subjects with ED exhibit higher levels of serum Hcy. However, due to the existence of publication bias, more rigorous and large-sample studies are needed.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melatonin and erectile dysfunction: addressing research gaps and proposing future investigations.","authors":"Amin Sharifan","doi":"10.1038/s41443-024-01002-5","DOIUrl":"https://doi.org/10.1038/s41443-024-01002-5","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142728198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sympathetic hypoactivity leads to hypocontractility of the corpus cavernosum in sickle cell mice: a mechanism contributing to priapism.","authors":"Tammyris Helena Rebecchi Silveira, Dalila Andrade Pereira, Fabiano Beraldi Calmasini, Fernando Ferreira Costa, Arthur L Burnett, Fábio Henrique Silva","doi":"10.1038/s41443-024-00997-1","DOIUrl":"https://doi.org/10.1038/s41443-024-00997-1","url":null,"abstract":"<p><p>Priapism, a prevalent complication in sickle cell disease (SCD) patients, manifests as prolonged and painful erections unrelated to sexual arousal. The detailed mechanisms contributing to this condition, especially regarding sympathetic function in the corpus cavernosum that maintains penile flaccidity, remain to be elucidated. In this study, it was hypothesized that the pathways of the sympathetic nervous system would be down-regulated, thereby contributing to the development of ischemic priapism in sickle cell disease. This study aimed to investigate the contractions induced by stimulation of sympathetic terminals and the expression of tyrosine hydroxylase in the corpora cavernosa of Berkeley SCD mice. C57BL/6 mice (wild-type, WT) and Berkeley SCD mice were used. A total of 22 mice were used in this study, with 11 allocated to the WT group and 11 to the SCD group. Mice corpus cavernosum was dissected free and mounted in 7-mL organ baths containing Krebs solution. Noradrenergic contractions were obtained using electrical-field stimulation (4-32 Hz) in corpus cavernosum strips from WT and SCD mice. Measurements of tyrosine hydroxylase phosphorylated at Ser-31 and total tyrosine hydroxylase protein expressions in cavernosal tissues were also measured by western blot. The neurogenic contractions were significantly lower (P < 0.05) in the SCD group compared to WT group at all tested frequencies. The protein expression of both total tyrosine hydroxylase and tyrosine hydroxylase phosphorylated at Ser-31 was significantly decreased by approximately 46.28% (P = 0.01) and 55.32% (P = 0.03) in cavernosal tissues from the SCD group compared to the control group, respectively. In conclusion, sympathetic hypoactivity characterized by the downregulation of tyrosine hydroxylase contributes to the hypocontractility of the corpus cavernosum in Berkeley SCD mice. This suggests an impairment in the mechanism responsible for maintaining penile flaccidity, potentially predisposing to erections without sexual stimulation, similar to those observed in ischemic priapism. Pharmacological treatments aiming to restore sympathetic tone in the penis might hold promise for addressing ischemic priapism in SCD.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142728202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflatable penile prosthesis implantation in the outpatient setting is safe and feasible: a prospective, singe center study.","authors":"Maximilian G Fidel, Jainik Shah, Dhiraj S Bal, Connor Roque, Yool Ko, Harliv Dhillon, Robert Bard, Alagarsamy Pandian, Jasmir G Nayak, Premal Patel","doi":"10.1038/s41443-024-01004-3","DOIUrl":"https://doi.org/10.1038/s41443-024-01004-3","url":null,"abstract":"<p><p>Inflatable penile prosthesis (IPP) implantations are commonly performed in hospital settings which accommodate an overnight stay and are increasingly being performed as day procedures in outpatient settings with same-day discharge. This study sought to investigate the safety and feasibility of day surgery insertion of an IPP. Surgical parameters and incidence of postoperative complications including infection, hospital admission, emergency room visitation, and additional analgesia were investigated. This prospective study included all adult patients undergoing day surgery insertion of an IPP at an ambulatory surgical center classified as ASA 1-3, between February 2023 and April 2024. All procedures were performed via infrapubic approach under spinal anesthesia or deep sedation with local anesthesia. 52 patients were enrolled with a mean age of 62.5 ± 3.1 [43-79] years. All procedures were performed successfully with no intra-operative complications. The mean surgery duration was 65.2 ± 17.9 [35-130] minutes. The mean recovery time was 115.9 ± 58.2 [50-323] minutes. No patients required hospital admission or had acquired a post-operative infection. One patient required emergency room visitation, which was unrelated to the surgery. 5.9% (n = 3) of patients required additional postoperative analgesia. Our results demonstrate the safety and feasibility of performing an IPP implantation in an outpatient setting.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Priapism in the paediatric and adolescent population.","authors":"Anah Mushtaq, Sudhindra Jayasimha, Wilson King Lim To, Imran Mushtaq","doi":"10.1038/s41443-024-00998-0","DOIUrl":"https://doi.org/10.1038/s41443-024-00998-0","url":null,"abstract":"<p><p>This study aimed to review the current knowledge on priapism in the paediatric and adolescent population through a review of the current literature. Priapism is defined as a prolonged and persistent penile erection lasting over 4 h, unassociated with a sexual stimulus or persisting after ejaculation and orgasm. It has an incidence of 0.3-1.5 per 100,000 per annum in males of all ages, and comprises 3 main types: ischaemic, non-ischaemic and stuttering. The most common cause of priapism in children is sickle cell disease, and these individuals usually have the ischaemic type of priapism, which is a true urological emergency. We discuss in this article the management pathways for children and young adults, with the main emphasis being on accurate diagnosis and emergent management. Erectile dysfunction is the main consequence of delayed management.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}