International Journal of Impotence Research最新文献

{"title":"Comparison of erectile and ejaculatory functional outcomes between unilateral and bilateral cavernosal rupture in penile fractures","authors":"Emin Taha Keskin, Osman Can, Yiğit Can Filtekin, Harun Özdemir, Mehmet Şahin, Gökhan Çeker, Cemal Topal, Halil Lütfi Canat","doi":"10.1038/s41443-024-00940-4","DOIUrl":"10.1038/s41443-024-00940-4","url":null,"abstract":"This study aimed to compare the erectile and ejaculatory functional outcomes of unilateral and bilateral ruptures of the corpus cavernosum in penile fractures. Sixty patients’ data were analyzed retrospectively between June 2020 and January 2023. The patients were divided into two groups based on the affected corpus cavernosum (unilateral and bilateral). Preoperative and postoperative 3rd-, 6th-, and 12th-month self-estimated intravaginal-ejaculation-latency-time (IELT), and international index of erectile function-erectile function (IIEF-EF) scores as well as the presence of urethral injury were compared. Bilateral corpus cavernosum fractures were detected in 18.3% of the patients. The IIEF-EF scores of both groups at 3rd-, 6th-, and 12th-month were found to be significantly lower than the preoperative scores (unilateral group:24.1 ± 2.7 vs 23.2 ± 3.5 and 23.3 ± 3.4, respectively, p = 0.011 and 0.014, respectively; bilateral group: 24 ± 1.9 vs 23 ± 1.8 and 23.2 ± 1.5, respectively, p = 0.027 and 0.047, respectively). No significant difference was found between the preoperative and the postoperative 12th month IIEF-EF scores in either group (unilateral group: 24.1 ± 2.7 vs 23.4 ± 3.6, p = 0.207;bilateral group:24 ± 1.9 vs 23.2 ± 1.5, p = 0.057). The self-estimated IELTs of both groups at the postoperative 3rd, 6th, and 12th months demonstrated a significant increase from the preoperative values (unilateral group: 221.6 ± 81.8 vs 252 ± 94.6, 256.5 ± 97.6, and 250.5 ± 104.8, respectively, p < 0.001; bilateral group:241.8 ± 61.6 vs 278.1 ± 55.4, 281.8 ± 56.1, and 283.6 ± 54.2, respectively, p = 0.041, 0.030, and 0.047, respectively). The changes in self-estimated IELTs and IIEF-EF scores between the preoperative period and the postoperative 3rd, 6th, and 12th-months were compared, and no statistical difference was found between patients with unilateral and bilateral corpus cavernosum fractures (p > 0.05). In conclusion, no significant difference in erectile function was found in either group at the 12-month follow-up, and the self-estimated IELTs were found to be prolonged in both groups. Furthermore, no difference was noted between the groups at any follow-up. To explain the effects of unilateral and bilateral injuries on erectile and ejaculatory functions, further studies with a larger-number of patients are necessary.","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41443-024-00940-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141450391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Patient out-of-pocket costs for guideline-recommended treatments for erectile dysfunction: a medicare cost modeling analysis.","authors":"Rosemary Iwuala, Omer A Raheem","doi":"10.1038/s41443-024-00899-2","DOIUrl":"https://doi.org/10.1038/s41443-024-00899-2","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence of sexual problems in the divorced population and the prevalence of separation in populations with sexual problems: a meta-analysis.","authors":"Saeedeh Zenoozian, Fatemeh Bayat, Ali Soltani, Mohammad Mehdi Mirloo, Roghieh Kharaghani","doi":"10.1038/s41443-024-00918-2","DOIUrl":"https://doi.org/10.1038/s41443-024-00918-2","url":null,"abstract":"<p><p>The prevalence of divorce has significantly increased in the world, and scattered studies reveal that one of the main causes of divorce is sexual problems. The present study aimed to review the existing studies on the prevalence of sexual problems in separated people such as divorce applicants and people separated due to sexual problems. Another aim of this study was to find the prevalence of separation in patients with diseases affecting sexual function. A wide range of articles were searched in electronic databases until 21 April, 2023. The studies on both sexual problems and separation were included. From among 4110 studies, the data of 14 studies were reviewed and meta-analyzed. The prevalence of sexual problems was found to be 47% (CI: 29-64%) in separated people, 43% (CI: 18-68%) in women, and 52% (CI: 25-79%) in men and the prevalence of separation was 16% (CI: 6-26%) in people with sexual problems, 27% (CI: 21-33%) in women, and 11% (CI: -1-23%) in men. Moreover, the prevalence of separation in patients with diseases affecting sexual function was 4% (CI: 2-6%), 2% (CI: 0-3%) in women, and 5% (CI: 2-8%) in men. A considerably high rate of separations could be attributed to sexual problems.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Penile prosthesis implantation is safe and effective in Peyronie's disease patients with and without erectile dysfunction.","authors":"Ignacio Moncada, Pramod Krishnappa, Claudia Zaccaro, Augustin Fraile, Javier Romero-Otero, Juan Ignacio Martinez-Salamanca, Enrique Lledó-Garcia","doi":"10.1038/s41443-024-00938-y","DOIUrl":"https://doi.org/10.1038/s41443-024-00938-y","url":null,"abstract":"<p><p>Penile prosthesis (PP) is the mainstay of treatment in Peyronie's disease (PD) with co-existent refractory erectile dysfunction (ED). This study aimed to assess the clinical outcomes of patients who underwent PP as the first-line surgical treatment in PD without ED. A total of 636 patients underwent PP for PD from 2012 to 2022, but only 168 patients who underwent PP as first-line surgical management for PD with or without ED were included in the study. The mean (SD) age of 168 patients was 56.3 years (12.4). The mean curvature of the \"PD with ED\" group and the \"PD without ED\" group were 38.2 (5.6) degrees and 42.2 (5.9) degrees. The median (IQR) follow-up was 56.0 months (34.5- 61.4). Most (86.9%) patients underwent 3-piece inflatable PP. An important finding is that 33 patients (19.6%) without ED had undergone PP. Mechanical failure requiring revision surgery was less common in the 'without ED' group than in the ED group (6.8% vs. 10.2%, p 0.04). Most PD patients without ED (87.9%, 29/33) and with ED (88.9%, 120/135) were \"satisfied\" after PP implantation at six months, as defined by a score of ≥4 on a 5-point Likert scale. If surgery is offered in PD, PP may be considered a safe and effective first-line surgical treatment regardless of the ED, given the acceptable complications and high satisfaction rates. However, this new concept warrants further research.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141440463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Therapeutic outcomes and analysis of Doppler findings in 25 patients with non-ischemic priapism.","authors":"Conrad von Stempel, Rohaan Shahzad, Miles Walkden, Fabio Castiglione, Asif Muneer, David Ralph, Alex Kirkham","doi":"10.1038/s41443-024-00936-0","DOIUrl":"https://doi.org/10.1038/s41443-024-00936-0","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141436883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Explicit measures for emotional congruence with children are related to sexual interests in a male community sample, but not implicit measures.","authors":"Dahlnym Yoon, Miriam J Hofmann, Andreas Mokros, Jonas Krüppel","doi":"10.1038/s41443-024-00911-9","DOIUrl":"https://doi.org/10.1038/s41443-024-00911-9","url":null,"abstract":"<p><p>This study sought to disentangle several phenotypic correlates of pedophilic sexual interests, such as emotional congruence with children and lack of empathy. We utilized Implicit Association Tests and self-report questionnaires for emotional congruence with children and analyzed the psychometric properties of these measures. Further, we analyzed the associations between these measures and self-reported pedophilic sexual interests and empathy. The sample consisted of 110 adult community males (prevalence of sexual interest in children at least to some extent: 5.5%) with or without child-related jobs (43.6% vs. 56.4%) recruited online in the general population. Overall, we found equivocal parameters for reliability of the implicit and explicit measures of emotional congruence with children (α = 0.29 to 0.76). The self-reported emotional congruence with children was only weakly linked to the implicit positive evaluations of children (r = 0.170, p = 0.039), not linked to empathy except for distress in social interactions (r = 0.199, p = 0.019), and moderately linked to deviant sexual interests in children (r = 0.321 to 0.404, p < 0.001), especially in men working with children (R² = 0.04, p = 0.027). Further studies are warranted to expand the sample to the offender population and explore the more complex network of constructs related to pedophilia.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141431935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hard-Flaccid syndrome: a survey of sexual medicine practitioners' knowledge and experience.","authors":"Gustavo Gryzinski, Muhammed Moukhtar Hammad, Laith Alzweri, Babak Azad, David Barham, Supanut Lumbiganon, Ege Can Serefoglu, Faysal Yafi","doi":"10.1038/s41443-024-00917-3","DOIUrl":"https://doi.org/10.1038/s41443-024-00917-3","url":null,"abstract":"<p><p>Hard-flaccid syndrome (HFS) is a poorly understood condition of male sexual dysfunction (MSD) that has more recently become a new topic of discussion in online forums and sexual medicine conferences. There has been limited research looking into HFS and consequently there are no evidence-based guidelines for its work-up and management. In order to identify the current level of understanding of HFS in the sexual medicine community, a survey was distributed at a national urologic conference focusing on pertinent management strategies employed by practitioners, and their own thoughts on HFS. This showed that nearly one-third of those surveyed had never seen HFS in their practice. Of those that had, diagnosis was mainly made via clinical history as well as patient self-diagnosis. Additionally, only about half of the respondents who had seen HFS were confident in its legitimacy as a real medical syndrome. This analysis is one of the first of its kind, and highlights the ongoing lack of familiarity of HFS among the sexual medicine community. There were limitations, most notably its survey format as well as low sample size, however, it importantly emphasizes the critical need for continued education and research into HFS to improve diagnostic accuracy, enhance patient care, and develop effective treatment strategies.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141426788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of microplastics in the human penis.","authors":"Jason Codrington, Alexandra Aponte Varnum, Lars Hildebrandt, Daniel Pröfrock, Joginder Bidhan, Kajal Khodamoradi, Anke-Lisa Höhme, Martin Held, Aymara Evans, David Velasquez, Christina C Yarborough, Bahareh Ghane-Motlagh, Ashutosh Agarwal, Justin Achua, Edoardo Pozzi, Francesco Mesquita, Francis Petrella, David Miller, Ranjith Ramasamy","doi":"10.1038/s41443-024-00930-6","DOIUrl":"10.1038/s41443-024-00930-6","url":null,"abstract":"<p><p>The proliferation of microplastics (MPs) represents a burgeoning environmental and health crisis. Measuring less than 5 mm in diameter, MPs have infiltrated atmospheric, freshwater, and terrestrial ecosystems, penetrating commonplace consumables like seafood, sea salt, and bottled beverages. Their size and surface area render them susceptible to chemical interactions with physiological fluids and tissues, raising bioaccumulation and toxicity concerns. Human exposure to MPs occurs through ingestion, inhalation, and dermal contact. To date, there is no direct evidence identifying MPs in penile tissue. The objective of this study was to assess for potential aggregation of MPs in penile tissue. Tissue samples were extracted from six individuals who underwent surgery for a multi-component inflatable penile prosthesis (IPP). Samples were obtained from the corpora using Adson forceps before corporotomy dilation and device implantation and placed into cleaned glassware. A control sample was collected and stored in a McKesson specimen plastic container. The tissue fractions were analyzed using the Agilent 8700 Laser Direct Infrared (LDIR) Chemical Imaging System (Agilent Technologies. Moreover, the morphology of the particles was investigated by a Zeiss Merlin Scanning Electron Microscope (SEM), complementing the detection range of LDIR to below 20 µm. MPs via LDIR were identified in 80% of the samples, ranging in size from 20-500 µm. Smaller particles down to 2 µm were detected via SEM. Seven types of MPs were found in the penile tissue, with polyethylene terephthalate (47.8%) and polypropylene (34.7%) being the most prevalent. The detection of MPs in penile tissue raises inquiries on the ramifications of environmental pollutants on sexual health. Our research adds a key dimension to the discussion on man-made pollutants, focusing on MPs in the male reproductive system.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141418812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative outcomes of partial versus total penectomy for penile carcinoma: A retrospective cohort study on demographics and postoperative complications.","authors":"David A Velasquez, Allison Liu, Senthooran Kalidoss, Clinton Yeaman, Darren Bryk, Judy N Fustok, Thomas M Shelton, Hasan Alhameedi, Nalin Payakachat, Mohamed Kamel, Braian R Ledesma, Mahmoud I Khalil, Ryan Smith, Omer Raheem","doi":"10.1038/s41443-024-00935-1","DOIUrl":"https://doi.org/10.1038/s41443-024-00935-1","url":null,"abstract":"<p><p>When feasible from an oncologic standpoint, partial penectomy (PP) is often preferred to total penectomy (TP) for penile cancer treatment, for the preservation of functional urinary outcomes. However, to date, there has not been a direct comparison of perioperative outcomes between PP and TP. Comparing treatments for penile cancer has proven difficult due to the rarity of penile cancer in the United States. We aimed to report differences in pre-operative risk factors, intra-operative outcomes, and postoperative outcomes between TP and PP for penile cancer. Using the National Surgical Quality Improvement Program database, we conducted a retrospective cohort review of penile cancer patients enlisted in the database between the years 2006-2016 using the International Classification of Diseases clinical modification 9th revision codes. A total of 260 patients, 67 TP and 193 PP patients, were included. PP patients were less likely to be transferred patients (p = 0.002), diabetic (p = 0.026), and were more likely to have preoperative laboratory values within normal limits. PP patients also had shorter lengths of stay in the hospital (p < 0.001) and operating time (p < 0.001). Significant differences were also found for inpatient stay (p < 0.001), 30-day post-surgery complications (p < 0.001), deep incisional surgical site infection (SSI) (p = 0.017), wound disruption (p = 0.017), intraoperative or postoperative transfusion (p = 0.029), and sepsis (p < 0.005). Finally, PP patients required fewer concurrent surgical procedures (p < 0.001). Demographic differences between PP and TP patients may reflect patients presenting with more advanced oncologic disease. PP is associated with fewer postoperative complications, shorter surgeries, shorter hospital stays, fewer concurrent surgical procedures, and comorbid conditions compared to TP. A gap remains in the reported data pertaining to postoperative sexual function and erectile outcomes for PP at a national level.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141418810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Comment on \"The post-finasteride syndrome: possible etiological mechanisms and symptoms\".","authors":"Michael A Perelman","doi":"10.1038/s41443-024-00916-4","DOIUrl":"https://doi.org/10.1038/s41443-024-00916-4","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141418811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}