Pre-spermatorrhea state: a novel therapeutic paradigm for the management of non-organic delayed ejaculation and anejaculation.

Delayed ejaculation (DE) and anejaculation (AE) pose significant clinical challenges in andrology and sexual medicine, with no universally effective or standardized treatments currently available. In clinical practice, management strategies are primarily empirical. Drawing inspiration from the physiological mechanisms underlying nocturnal emissions, we propose a novel therapeutic approach for non-organic DE and AE. This method aims to facilitate ejaculation by enhancing seminal vesicle fluid secretion, thereby increasing prostatic urethral pressure during sexual activity. To this end, we administered Yangjing Capsules, a traditional Chinese herbal formulation with kidney-tonifying properties, to promote seminal vesicles secretory function. Preliminary clinical findings demonstrated an efficacy rate of 83.3% in the treatment group, compared to 40% in the control group treated with ephedrine tablets (RR = 2.083; 95% CI:1.331-3.626; P = 0.0016). We anticipate that this strategy may offer a novel option for the clinical management of non-organic DE and AE and provide new insights into therapeutic development in this field.