International Journal of Artificial Organs最新文献_第3页

Polyethylene and silicone insoles for patient-specific conditions using computational and experimental methods. 聚乙烯和硅胶鞋垫的病人特定条件下使用计算和实验方法。

IF 1.3 4区医学

International Journal of Artificial Organs Pub Date : 2025-08-01 Epub Date: 2025-07-02 DOI: 10.1177/03913988251355080

Hinpetch Daungsupawong, Viroj Wiwanitkit

引用次数: 0

Development of a novel bifunctional and volume-stable soft tissue substitute for peri-implant soft tissue and bone integration. 一种新型的双功能和体积稳定的软组织替代品，用于种植体周围软组织和骨整合。

IF 1.3 4区医学

International Journal of Artificial Organs Pub Date : 2025-08-01 Epub Date: 2025-07-06 DOI: 10.1177/03913988251355095

Krittaphat Fusang, Prisana Pripatnanont, Jirut Meesane, Jutakan Thonglam, Naruporn Monmaturapoj

{"title":"Development of a novel bifunctional and volume-stable soft tissue substitute for peri-implant soft tissue and bone integration.","authors":"Krittaphat Fusang, Prisana Pripatnanont, Jirut Meesane, Jutakan Thonglam, Naruporn Monmaturapoj","doi":"10.1177/03913988251355095","DOIUrl":"10.1177/03913988251355095","url":null,"abstract":"The collagen-based soft tissue substitutes are popularly used instead of autogenous connective tissue grafts (CTG). However, it has some drawbacks, such as rapid degradation and compromised volume stability. The novel bifunctional and volume-stable soft tissue substitute (BVSS), based on polyvinyl alcohol (PVA), biphasic calcium phosphate (BCP), and fish collagen was developed to overcome those mentioned problems. The physicochemical and mechanical properties were characterized and compared using scanning electron microscopy (SEM), degradation and swelling behavior, Fourier transform infrared spectroscopy(FT-IR), differential scanning calorimetry (DSC), and tensile testing, respectively. The biocompatibility was evaluated with fibroblast and osteoblast cells. The SEM images showed a rough and porous surface with interconnected porous structures. The 3% PVA-based scaffolds showed a suitable degradation rate in collagenase (40%-50%), more than 5% PVA (20%-30%) in 8 weeks. All prepared BVSS presented high water absorption rates. The 5% PVA-based scaffolds showed higher tensile strength than the 3% PVA-based scaffolds. The 3% 8:2 and 5% 8:2 demonstrated good cell proliferation and adhesion of both fibroblast and osteoblast cells on the scaffold. The prepared BVSS is compatible with hard and soft tissues and maintains a volume-stable character, making it ideal as a bifunctional peri-implant tissue scaffold.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"604-621"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of the influence of blade angle distribution on hemodynamic and hemocompatibility performance in a miniature axial blood pump. 叶片角度分布对小型轴向血泵血流动力学和血液相容性影响的研究。

IF 1.3 4区医学

International Journal of Artificial Organs Pub Date : 2025-08-01 Epub Date: 2025-06-25 DOI: 10.1177/03913988251349000

Zhi-Peng He, Shen Lv, Guang-Mao Liu, Sheng-Shou Hu

{"title":"Study of the influence of blade angle distribution on hemodynamic and hemocompatibility performance in a miniature axial blood pump.","authors":"Zhi-Peng He, Shen Lv, Guang-Mao Liu, Sheng-Shou Hu","doi":"10.1177/03913988251349000","DOIUrl":"10.1177/03913988251349000","url":null,"abstract":"High shear stress and turbulence in a miniature axial blood pump are affected by the pump's blade structure. which impacts the pump's hemodynamics and hemocompatibility performance. This study designed blades for a miniature axial blood pump via computational fluid dynamics (CFD). The optimal blade angle distribution must improve hemodynamic and hemocompatibility performance under the designed operating conditions (45,000 rpm rotational speed and 3 L/min flow rate). First, the blade inlet angles β1 were varied from -100° to -220°. Second, using the optimal β1, the blade angle distribution was changed by setting different curvatures at different curvature positions. Finally, the relationships among blade angle distribution parameters and hemodynamic, hemolysis, and thrombosis risk were analyzed. The results indicated that angle distribution should avoid positive curvature, and that \"the absolute value of negative curvature percentage should increase progressively with the increasing of curvature position.\" Compared with the original impeller, the CFD and experimental results revealed an optimized impeller with a 17.4% increase in pressure head, a 2.1% increase in hydraulic efficiency, an 8.4% decrease in hemolysis index, and a 5.3% decrease in volume-averaged scaled activated platelet concentration. CFD-guided blade angle optimization can improve the hemodynamic and hemocompatibility performance of miniature axial blood pumps.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"590-603"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early versus late addition of enteral analgesia and sedation adjuncts in patients on veno-venous extracorporeal membrane oxygenation. 静脉-静脉体外膜氧合患者早期与晚期添加肠内镇痛和镇静辅助药物。

IF 1.3 4区医学

International Journal of Artificial Organs Pub Date : 2025-08-01 Epub Date: 2025-07-27 DOI: 10.1177/03913988251359132

Aliya Abdulla, Mariah Sigala, Diane Dreucean, Kevin R Donahue, Prakruthi Voore, Celia Morton

{"title":"Early versus late addition of enteral analgesia and sedation adjuncts in patients on veno-venous extracorporeal membrane oxygenation.","authors":"Aliya Abdulla, Mariah Sigala, Diane Dreucean, Kevin R Donahue, Prakruthi Voore, Celia Morton","doi":"10.1177/03913988251359132","DOIUrl":"10.1177/03913988251359132","url":null,"abstract":"Purpose: Patients on veno-venous extracorporeal membrane oxygenation (VV ECMO) have shown to have higher intravenous (IV) sedation requirements and prolonged mechanical ventilation (MV) time. Literature suggests that early extubation and mobility improve survival; however, inability to wean IV analgosedation is a barrier. A strategy to decrease IV sedation is the use of adjunct enteral sedative, anxiolytic, and analgesic agents, although there is limited supportive data. The objective of this study was to assess the impact of early versus late (⩽72 h vs >72 h from time of cannulation) addition of enteral adjunct agents on continuous sedation/analgesic requirements in VV ECMO patients.Major findings: The study included 61 patients in the early group and 59 patients in the late. There was no difference in the primary outcome of time to ⩽1 continuous infusion analgosedation agent from ECMO cannulation. Incidence of adverse drug events were not shown to be increased between groups. No difference was seen in MV duration; however, early initiation of adjuncts resulted in a shorter intensive care unit length of stay.Conclusion: While early adjunct use did not impact weaning of IV sedation, the lack of major safety events and potential benefits seen may support adjunct use in this patient population.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"581-589"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and validation of machine learning predictive models for assessing dialysis adequacy in dialysis patients. 用于评估透析患者透析充分性的机器学习预测模型的开发和验证。

IF 1.3 4区医学

International Journal of Artificial Organs Pub Date : 2025-08-01 Epub Date: 2025-07-28 DOI: 10.1177/03913988251355082

Jie Zhou, Hao Wu, Linge Zhang, Qiaona Zhang, Jie Wang, Hang Zhao, Yongqi Dang, Shiyu Zhang, Lu Li

{"title":"Development and validation of machine learning predictive models for assessing dialysis adequacy in dialysis patients.","authors":"Jie Zhou, Hao Wu, Linge Zhang, Qiaona Zhang, Jie Wang, Hang Zhao, Yongqi Dang, Shiyu Zhang, Lu Li","doi":"10.1177/03913988251355082","DOIUrl":"10.1177/03913988251355082","url":null,"abstract":"Purpose: The assessment of dialysis adequacy is of great clinical importance. However, it depends on the nonlinear effects of numerous confounding factors and is therefore difficult to predict using traditional statistical methods. In this study, we used Random Forest (RF), Extreme Gradient Boosting (XGBoost), and Least Absolute Shrinkage and Selection Operator Regression (LASSO) to assess dialysis adequacy.Methods: A training set (70%) and a test set (30%) were randomly selected from the 264 dialysis patient case records collected for this study. We compared the machine learning models with statistical logistic regression prediction models. In addition, we performed fivefold cross internal validation and external validation.Results: The test dataset showed sensitivity values of 0.86 (95% CI = 0.75-0.96), 0.81 (95% CI = 0.69-0.93), and 0.72 (95% CI = 0.58-0.85) for the RF, XGBoost, and LASSO models, respectively. The matched specificity was 0.73 (95% CI = 0.58-0.87), 0.81 (95% CI = 0.67-0.93), and 0.83 (95% CI = 0.71-0.95). Accuracy was 0.80 (95% CI = 0.71-0.89), 0.81 (95% CI = 0.72-0.90), and 0.77 (95% CI = 0.68-0.86). F1 scores were 0.83 (95% CI = 0.72-0.90), 0.82 (95% CI = 0.73-0.91), and 0.78 (95% CI = 0.67-0.87). The receiver operating characteristic curves (AUROC) were 0.88 (p < 0.05, 95% CI = 0.70-0.88), 0.86 (p = 0.12, 95% CI = 0.72-0.90), and 0.88 (p < 0.05, 95% CI = 0.69-0.86). The mean absolute errors (MAE) of the calibration curves were 0.15, 0.11, and 0.07. In addition, the decision curve analysis (DCA) showed wide intervals of net clinical benefit for the models.Conclusion: Machine learning can be used to predict dialysis adequacy for optimal RF performance.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"557-565"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Left ventricular assist device exchanges: A safe and effective strategy in the era of limited organ availability. 左心室辅助装置交换：在器官供应有限的时代一种安全有效的策略。

IF 1.3 4区医学

International Journal of Artificial Organs Pub Date : 2025-08-01 Epub Date: 2025-06-25 DOI: 10.1177/03913988251351116

Nandini Nair, Kenny Nguyen, Dongping Du, Aditya Mahesh, Behzad Soleimani, Balakrishnan Mahesh

{"title":"Left ventricular assist device exchanges: A safe and effective strategy in the era of limited organ availability.","authors":"Nandini Nair, Kenny Nguyen, Dongping Du, Aditya Mahesh, Behzad Soleimani, Balakrishnan Mahesh","doi":"10.1177/03913988251351116","DOIUrl":"10.1177/03913988251351116","url":null,"abstract":"Background: Ongoing donor-organ shortage has limited transplantation making LVADs an effective alternative therapy for patients with end-stage heart failure. When LVAD-associated complications arise device exchange is a feasible and safe alternative. This study addresses the factors that impact survival post-LVAD exchange.Methods: Our decoded database was constructed retrospectively. Surgical details, device features, and re-intervention information were studied. The primary outcome was mortality. Kaplan-Meier estimators were used for post-pump exchange survival analysis. Pairwise log-rank tests compare the survivals between different groups within each variable. p-Value <0.05 was considered significant. Backward-stepwise regression was used to construct the multivariable model using a subset of variables, retaining only variables with a p-value <0.1. Hazard ratios, their 95% confidence intervals, and p-values of the significant variables were reported.Results: Analysis of factors impacting survival post-pump exchange study showed a poor survival probability of only primary midline-sternotomy/redo (p = 0.005). Multivariable analysis showed that bridging with ECMO was protective with a hazard ratio of 0.16 (0.03-0.86, p = 0.03).Conclusions: The overall survival probability is 50% at 4 years post-pump exchange. This study highlights the differences in post-exchange outcomes depending on the device types and surgical approaches used. LVAD exchange for device-related complications can be performed in high-risk patients as a viable alternative to heart transplantation in the setting of the current heart allocation prioritization systems.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"566-574"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12332217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Red blood cell damage during normothermic liver perfusion: A hidden barrier to graft assessment? 常温肝灌注时红细胞损伤：移植评估的隐藏障碍？

IF 1.3 4区医学

International Journal of Artificial Organs Pub Date : 2025-08-01 Epub Date: 2025-07-15 DOI: 10.1177/03913988251351513

Andres Rivera, Ignacio Fernandez-Lopez, Juan F Del Canizo

{"title":"Red blood cell damage during normothermic liver perfusion: A hidden barrier to graft assessment?","authors":"Andres Rivera, Ignacio Fernandez-Lopez, Juan F Del Canizo","doi":"10.1177/03913988251351513","DOIUrl":"10.1177/03913988251351513","url":null,"abstract":"Background: Normothermic machine for liver perfusion (NMP) has emerged as a promising technique for dynamic preservation and functional assessment of liver grafts. However, red blood cell hemolysis is a frequently underestimated complication that may impair the interpretation of viability metrics. This study aims to determine the impact of rising free hemoglobin levels (fHb) on hepatic perfusion during NMP.Materials and methods: Fifteen healthy female porcine livers were perfused for 18 hours using a NMP circuit primed with autologous whole blood. Hourly measurements included fHb levels, total hepatic, portal, and arterial flows, as well as biochemical parameters. Correlations between fHb and perfusion parameters were evaluated using Spearman's rank test.Results: All livers were successfully perfused for 18 h. Free hemoglobin levels progressively increased over time. Significant inverse correlations were observed between fHb and portal vein flow (ρ = -0.772) and total hepatic flow (ρ = -0.650). Among biochemical markers, only GGT and CK showed positive correlations with fHb.Conclusion: Progressive hemolysis during NMP is associated with impaired hepatic perfusion, affecting the portal system, and correlates with selective biochemical injury markers. These findings highlight the need for systematic monitoring of fHb in NMP protocols to ensure viability assessment and optimize graft preservation.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"550-556"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Critical appraisal of Zhu et al.'s magnetic drive blood pump: Toward clinical translation. 对朱等人的磁驱动血泵的批判性评价：走向临床翻译。

IF 1.3 4区医学

International Journal of Artificial Organs Pub Date : 2025-07-30 DOI: 10.1177/03913988251360563

Abdullah Saad

引用次数: 0

The effect of bioactive compounds extracted from natural rubber serum on wound healing: An in vitro study. 天然橡胶血清中提取的生物活性化合物对伤口愈合的影响：体外研究。

IF 1.3 4区医学

International Journal of Artificial Organs Pub Date : 2025-07-30 DOI: 10.1177/03913988251360554

Prisana Pripatnanont, Kawintip Prasongyuenyong, Jutakan Thonglam, Kanokporn Santavalimp, Thanawat Pitakpornpreecha, Aratee Aroonkesorn

{"title":"The effect of bioactive compounds extracted from natural rubber serum on wound healing: An in vitro study.","authors":"Prisana Pripatnanont, Kawintip Prasongyuenyong, Jutakan Thonglam, Kanokporn Santavalimp, Thanawat Pitakpornpreecha, Aratee Aroonkesorn","doi":"10.1177/03913988251360554","DOIUrl":"https://doi.org/10.1177/03913988251360554","url":null,"abstract":"Background: Wound healing is a complex process that involves a sequential interplay of inflammation, cell proliferation, and migration. Natural rubber extracts have been explored in cell migration and proliferation, playing a pivotal role in tissue regeneration.Objectives: This study identified and fractionated bioactive elements in natural rubber serum and investigated their effect on wound healing capacity.Methods: The fractions were obtained through anion exchange chromatography, acetone precipitation, and ammonium sulfate precipitation. Wound healing effects were studied in vitro through fibroblast cell proliferation, scratch assay, and fibroblast cytotoxicity by live-dead cell staining.Results: Specific fractions R10k0.2, R10k0.4, R1k1, R1k0.6, and R1k0.8 were obtained through anion chromatography. Only the R1k-unbound, R1k0.6, and R1k0.8 promoted fibroblast proliferation, and those fractions were further extracted by acetone precipitation and ammonium sulfate. These fractions expedited wound gap closure in migration assays. Sugar compounds and carbohydrates were primarily identified in the fractions from anion exchange chromatography, while protein constituents were found from ammonium sulfate precipitation.Conclusions: The bioactive fractions from natural rubber serum primarily consisted of sugar compounds with trace amounts of proteins. The carbohydrates extracted enhanced fibroblast proliferation and migration with no toxicity to the cells. These compounds possessed potential applications in wound healing and tissue regeneration.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988251360554"},"PeriodicalIF":1.3,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro assessment of cefepime adsorption in filters used during renal replacement therapy. 肾替代治疗中使用的过滤器对头孢吡肟吸附的体外评估。

IF 1.3 4区医学

International Journal of Artificial Organs Pub Date : 2025-07-28 DOI: 10.1177/03913988251356124

Valentin Maulet, Jessica Le Ven, Louis Fonlupt, Céline Mory, Solange Corriol-Rohou, Frederic J Baud, Alban Le Monnier

{"title":"In vitro assessment of cefepime adsorption in filters used during renal replacement therapy.","authors":"Valentin Maulet, Jessica Le Ven, Louis Fonlupt, Céline Mory, Solange Corriol-Rohou, Frederic J Baud, Alban Le Monnier","doi":"10.1177/03913988251356124","DOIUrl":"https://doi.org/10.1177/03913988251356124","url":null,"abstract":"Introduction: Renal replacement therapy efficiently eliminates cefepime. A published in vitro study concluded to minimal adsorption of cefepime in a polysulfone derived filter. We aimed at assessing cefepime adsorption in filters used in critically ill patients.Methods: Two filters were used, ST™150 and AV™1000. Adsorption was assessed in two modes, including diafiltration and filtration set to flow rates of from 2.5 to 1 L/h, respectively. Routes of elimination were assessed using NeckEpur® method for 6-h session duration.Results: The mean initial concentration in the 5-L central compartment (CC) in the 10 sessions was 47.7 ± 2.9 mg/L. Using the diafiltration mode, the mean adsorption rates in the ST™150 and AV™1000 were 1.3 ± 2.3% and 19.7 ± 1.2% (n = 3), respectively. Using the filtration mode at 1 L/h, the mean adsorption rates in the ST™150 and AV™1000 were 1.7% (n = 2) and 18.5% (n = 2), respectively.Conclusion: ST™150 filter sequestrated very limited quantities of cefepime. In the diafiltration and filtration modes, AV™1000 sequestered cefepime at about 19%. The adsorption rate seems independent of the flow rate. Further studies would be needed to assess, in particular, the clinical relevance of these results in adults as well as drug adsorption in the pediatric population.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988251356124"},"PeriodicalIF":1.3,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0