International Journal of Artificial Organs最新文献

{"title":"Response to \"Comparison of the use of standard heparin and 0.9% saline as lock solution in hemodialysis catheter: Importance of closure technique.\"","authors":"Daniele Privitera, Davide Giustivi","doi":"10.1177/03913988251322691","DOIUrl":"10.1177/03913988251322691","url":null,"abstract":"","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"219-220"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Encapsulation of trabecular meshwork mesenchymal stem cell using microfluidic system for differentiation into neuron-like cells.","authors":"Sina Rahmani, Samad Nadri, Mehdi Eskandari, Hossein Mostafavi","doi":"10.1177/03913988251333280","DOIUrl":"10.1177/03913988251333280","url":null,"abstract":"<p><strong>Objective: </strong>Neurodegenerative diseases are a class of nervous system disorders characterized by progressive neuronal degeneration and loss of function. Among emerging therapeutic approaches, microfluidic-enabled stem cell encapsulation and transplantation has gained recognition as a promising strategy for mitigating neuronal damage. In this work, human mesenchymal stem cells (MSCs), isolated from trabecular meshwork (TM) tissue, were successfully encapsulated and differentiated into neural-like cells via a microfluidic platform to demonstrate their potential for neural repair applications.</p><p><strong>Materials and methods: </strong>The isolated mesenchymal stem cells were cultured on a microfluidic system (fabricated by soft lithography methods) and treated with medium containing DMEM supplemented with RA, IBMX, and forskolin for 7 days. Quantitative PCR (qPCR) were used to analyze differentiated TM-MSC and their expression of neural-like specific markers such as Nestin and b-tubulin 3.</p><p><strong>Results: </strong>qPCR analysis revealed the presence of genes characteristic of neural cells (Nestin and β-tubulin 3) in cells differentiated both within a microfluidic system and on traditional tissue culture plates (TCPS). qPCR result showed that cells on 1.5% alginate showed higher expression of β-tubulin 3 compared to those on 1% alginate, 2% alginate, and TCPS (<i>p</i> < 0.0001). In contrast, Nestin expression showed no statistically significant differences across all pairwise comparisons (<i>p</i> > 0.05 for all groups).</p><p><strong>Conclusion: </strong>The findings indicate that mesenchymal stem cells derived from the trabecular meshwork (TM-MSCs) may serve as promising candidates for cell-based therapeutic strategies. Furthermore, the microfluidic platform implemented in this study exhibits potential utility as a delivery vehicle for TM-MSCs in therapeutic interventions targeting neurological disorders.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"258-264"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the mechanical properties of bond strength in adhesive systems bonded to HCR silicone facial.","authors":"Marcelo Coelho Goiato, Nayla Caroline Santos Yamamoto, Clóvis Lamartine de Moraes Melo Neto, Emily Vivianne Freitas da Silva, Fernanda Pereira de Caxias, Daniela Micheline Dos Santos","doi":"10.1177/03913988251325680","DOIUrl":"10.1177/03913988251325680","url":null,"abstract":"<p><strong>Objective: </strong>Therefore, this study aimed to evaluate the maximum displacement resistance of silicone samples adhered to human skin using different adhesives. For this purpose, colorless silicone samples (A-4530-HCRA Silicone Gum HCR) pigmented with Functional Intrinsic II Silicone Coloring System were made and distributed into five groups (1. SA specific adhesive for maxillofacial prostheses: Drying Adhesive; 2. GHPG hair prosthesis glue; 3.GFEG semi-permanent fake eyelash glue; 4. GCLG colorless liquid glue; and 5. GDAT and denture adhesive tape). Four times were used, 30 min (<i>T</i>0), 240 (<i>T</i>1), and 480 min (<i>T</i>2) after the samples were adhered to the volunteer's forearm.</p><p><strong>Results: </strong>The maximum silicone displacement force was greater for the Hair Prosthesis Glue group (GHPG) in the <i>T</i>0 and <i>T</i>2 periods.</p><p><strong>Conclusion: </strong>The results show that hair glue (GHPG) would be an alternative option for use in maxillofacial prostheses and denture adhesive tape (GDAT) showed a lack of effective adhesion.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"275-279"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An innovative model of <i>en bloc</i> liver-pancreas-kidney preservation via ex vivo hypothermic acellular machine perfusion.","authors":"Ruy J Cruz, Flavio Fh Galvao, Anderson Benicio","doi":"10.1177/03913988251330084","DOIUrl":"10.1177/03913988251330084","url":null,"abstract":"<p><strong>Background: </strong>Liver machine perfusion (MP) has emerged as a promising organ preservation modality. Recent studies have shown that the addition of the kidneys to the circuit improves the biochemical environment and could benefit liver preservation. The aim of this study was to explore the technical and anatomical feasibility of <i>en bloc</i> liver-pancreas-kidney MP. We also examined the safety of ex vivo perfusion with a nonoxygen carrier solution and its effects on acid-base and metabolic parameters using this novel multivisceral perfusion platform.</p><p><strong>Methods: </strong>Five multivisceral allografts, including liver, pancreas, duodenum, and kidney, were perfused for 4 h with acellular perfusate. Hemodynamic and laboratory data were evaluated throughout the experiment.</p><p><strong>Results: </strong>No system failure was reported. There were minimal changes in the acid-base parameters during the experiment. Lactate and glucose levels were stable throughout hypothermic perfusion. There was a mild increase in liver function parameters in the last hour of hypothermic perfusion. No changes in creatinine levels were observed throughout the study. The urine output increased steadily during the experiment, with an average of 155.6 mL/h.</p><p><strong>Conclusion: </strong>We described an innovative multivisceral MP technique that could be further used as a platform for physiological studies and targeted therapeutic interventions. Further investigations are necessary to evaluate this ex vivo perfusion technique and provide insights into the feasibility of hypothermic acellular multivisceral MP in clinical scenarios.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"241-249"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between systemic coagulation-inflammation index and proximal upper-extremity arteriovenous graft thrombosis in hemodialysis patients.","authors":"Demir Cetintas, Hakan Guven","doi":"10.1177/03913988251323733","DOIUrl":"10.1177/03913988251323733","url":null,"abstract":"<p><strong>Introduction: </strong>To the best of our knowledge, the potential predictive association between systemic coagulation-inflammation index (SCI) and arteriovenous graft (AVG) thrombosis following proximal upper-extremity AVG surgery has not yet been investigated. Thus, in this study, we investigated the predictive value of SCI on postoperative early-term AVG thrombosis in patients undergoing proximal upper-extremity AVG surgery for hemodialysis access.</p><p><strong>Methods: </strong>A total of 118 hemodialysis patients undergoing proximal upper-extremity AVG surgery were enrolled to this retrospective observational cohort study. The patients were categorized into two groups in accordance with whether postoperative early-term AVG thrombosis developed; as thrombosed AVG group (<i>n</i> = 37) and non-thrombosed AVG group (<i>n</i> = 81). Basic clinical features and laboratory test results of the patients were recorded and compared between the groups.</p><p><strong>Results: </strong>Patients in thrombosed AVG group were significantly older than those in non-thrombosed AVG group. The mean WBC and neutrophil counts were significantly lower whereas the mean fibrinogen and median SCI values were significantly higher in thrombosed AVG group compared to non-thrombosed AVG group. In terms of other basic clinical features and laboratory tests, there were no significant differences between both groups in univariate analyses. In multivariate logistic regression analysis, only age and SCI maintained their statistical significance and thus were accepted as independent predictors of AVG thrombosis. ROC analysis demonstrated that SCI of 47 g/L constituted the optimum cut-off value with 94.6% sensitivity and 88.9% specificity rates in predicting AVG thrombosis.</p><p><strong>Conclusion: </strong>Our study revealed for the first time in the literature that SCI independently predicted postoperative early-term AVG thrombosis in hemodialysis patients undergoing proximal upper-extremity AVG surgery.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"222-228"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply \"Comparison of the use of standard heparin and 0.9% saline as lock solution in hemodialysis catheters\".","authors":"Fatih Ergül","doi":"10.1177/03913988251325339","DOIUrl":"10.1177/03913988251325339","url":null,"abstract":"","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"221"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Who should make the decision for renal replacement therapy?","authors":"Edip Erkuş, Rojda Kotan, Doğan Nasır Binici","doi":"10.1177/03913988251323758","DOIUrl":"10.1177/03913988251323758","url":null,"abstract":"<p><strong>Introduction: </strong>In this study, we aimed to evaluate cognitive functions in Stage 4 and 5 CKD patients using the Montreal Cognitive Assessment (MoCA) Scale, which objectively assesses cognitive dysfunction and various cognitive functions, and to compare them with a control group with normal kidney functions.</p><p><strong>Methods: </strong>All participants in our case-control study were administered the Montreal Cognitive Assessment (MoCA) Test, and total scores, subscale scores, and the presence of cognitive dysfunction were recorded.</p><p><strong>Results: </strong>When the groups were compared in terms of cognitive dysfunction (CD), 12.9% of the control group and 37.1% of the case group were found to have CD, which was statistically significant. When the groups were compared in terms of data and scale scores, the visual construction subscale score, naming, delayed recall subscale score, and total MoCA score were found to be significantly lower in the case group compared to the control group.</p><p><strong>Conclusion: </strong>Our study is the first to use the MoCA test with the correct reference range. The significant impairment observed in the cognitive functions of patients with advanced-stage CKD in our study suggests that the decision for renal replacement therapy should not be made by the patient alone, as it may be incorrect.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"229-234"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal design and analysis of a novel magnetic drive blood pump.","authors":"Zina Zhu, Yupeng Zhang, Renyu Wan, Peng Wu, Guohua Cui","doi":"10.1177/03913988251316678","DOIUrl":"10.1177/03913988251316678","url":null,"abstract":"<p><p>Utilizing magnetic coupling to drive the artificial heart blood pump in a non-contact and wireless manner offers a viable solution that can effectively avoid problems such as percutaneous lead infection. However, the existing magnetic drive blood pumps have problems such as low utilization efficiency and limited transmission torque due to significant leakage of permanent magnets. To address these limitations, this paper introduces a magnetic modulation-based magnetic drive blood pump, which uses salient pole iron sheets to modulate the magnetic field generated by permanent magnets, thereby minimizing leakage and enhancing the efficiency of permanent magnet utilization. Through finite element analysis of electromagnetic fields, the magnetic circuit structure of the magnetic modulation type magnetic drive blood pump is optimized. Additionally, the influence of the air gap distance of the magnetic drive blood pump on transmission performance is analyzed. Finally, a comprehensive experimental setup for blood pump is developed. By measuring the load torque and spatial magnetic flux density parameters of the magnetic drive blood pump and comparing them to the simulation outcomes, the effectiveness of the proposed magnetic modulation type blood pump is verified.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"160-169"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of obesity on outcomes in patients receiving extracorporeal membrane oxygenation: A systematic review and meta-analysis.","authors":"Wincy Wing-Sze Ng, Ka-Chun Leung, Rex Wan-Hin Hui, Pauline Yeung Ng, Chun-Wai Ngai, Simon Wai-Ching Sin","doi":"10.1177/03913988251315617","DOIUrl":"10.1177/03913988251315617","url":null,"abstract":"<p><p>Given the growing obesity pandemic, the impact of obesity on outcomes of Extracorporeal Membrane Oxygenation (ECMO) would be increasingly relevant to our daily practise. This meta-analysis aims to evaluate the impact of obesity on ECMO outcomes, integrating the latest evidence. Systematic literature search was conducted from inception until December 2024 on MEDLINE, Embase and the Cochrane Library using the terms 'ECMO', 'obesity', and their related terms. Twenty-eight studies were included from 2013 to 2024, including a total of 74,330 ECMO patients (Mean age 52.84 ± 13.55 years). Obese patients had a similar risk of in-hospital or 30-day mortality when compared to non-obese patients (Risk difference -2%, 95%CI -5% to -1%, <i>I</i>² = 85%, <i>p</i> = 0.25). Subgroup analysis of patients on V-V-ECMO showed a trend towards lower mortality in obese patients which did not reach statistical significance (risk difference -6%, 95%CI -13% to 0%, <i><u>I</u></i>² = 53%, <i>p</i> = 0.06). Subgroup analysis of patients on V-A-ECMO showed significantly higher mortality in obese patients (risk difference 5%, 95%CI 1% to 9%, <i>I</i>² = 54%, <i>p</i> = 0.007). Regarding secondary outcomes, obesity had no significant association with major bleeding or thrombotic complications (Risk difference 0%, 95%CI -1% to 2%, <i>I</i>² = 15%, <i>p</i> = 0.63). Obesity was associated with significantly shorter hospital length-of-stay (Mean difference -2.92 days, 95% CI -5.03 to -0.80, <i>I</i>² = 74%, <i>p</i> = 0.007), but had no impact on ECMO duration (Mean difference 0.35 days, 95%CI -0.03 to 0.74, <i>I</i>² = 41%, <i>p</i> = 0.07). In summary, our meta-analysis showed that obesity was a favourable prognostic factor in V-V-ECMO. However, obesity increased mortality in V-A-ECMO patients. The modality of ECMO support should be taken into consideration when evaluating ECMO candidacy in individual obese patients.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"211-215"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are there any session-to-session changes in ventilation during a weekly hemodialysis cycle?","authors":"Mauro Pietribiasi, John K Leypoldt, Monika Wieliczko, Malgorzata Debowska, Jolanta Malyszko, Jacek Waniewski","doi":"10.1177/03913988251314664","DOIUrl":"10.1177/03913988251314664","url":null,"abstract":"<p><p>Significant changes in pre-dialytic partial pressure of CO₂ (pCO₂) during a week-long cycle of hemodialysis (HD) can be an effect of the intermittent supplementation of bicarbonate to correct chronic acidosis in patients. Mathematical modeling efforts carried out using the same parameters before each HD session might fail to produce accurate predictions of pCO₂ and plasma bicarbonate concentration (C_Bic) because of this variability. A numerical model describing acid-base equilibrium changes during HD was applied to predict pCO₂, pH, and C_Bic in 24 chronic HD patients, using both fixed parameters for the whole week and estimating a new value of minute ventilation (V_E) and net acid generation rate (G_H) for each interdialytic interval. Dialysances of bicarbonate and dissolved CO₂ were also estimated independently for each HD session. The error of the model compared to the pre-dialytic data of C_Bic and pCO₂ significantly decreased when V_E and G_H were estimated piecewise throughout the week. To fit the data, V_E changed from 3.9 ± 1.0 mL/min before HD1, to 3.8e1 mL/min after HD1, 3.6 ± 1.0 mL/min after HD2, and 3.9 ± 1.1 mL/min after HD3 (<i>p</i> < 0.05). G_H changes after each session were not statistically significant. V_E values strongly correlated with pre-dialytic pCO₂ (Spearman's ρ = -0.97), but G_H only weakly correlated with pre-dialytic C_Bic (ρ = -0.30). Acid-base equilibrium is extremely sensitive to respiratory regulation. When attempting to predict the evolution of pCO₂ a C_Bic during the HD cycle, changes in the respiration parameters must be accounted for by the model, at the risk of a significant loss of prediction accuracy.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"180-187"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}