In vitro assessment of cefepime adsorption in filters used during renal replacement therapy.

IF 1.3 4区医学 Q4 ENGINEERING, BIOMEDICAL

International Journal of Artificial Organs Pub Date : 2025-07-28 DOI:10.1177/03913988251356124

Valentin Maulet, Jessica Le Ven, Louis Fonlupt, Céline Mory, Solange Corriol-Rohou, Frederic J Baud, Alban Le Monnier

{"title":"In vitro assessment of cefepime adsorption in filters used during renal replacement therapy.","authors":"Valentin Maulet, Jessica Le Ven, Louis Fonlupt, Céline Mory, Solange Corriol-Rohou, Frederic J Baud, Alban Le Monnier","doi":"10.1177/03913988251356124","DOIUrl":null,"url":null,"abstract":"Introduction: Renal replacement therapy efficiently eliminates cefepime. A published in vitro study concluded to minimal adsorption of cefepime in a polysulfone derived filter. We aimed at assessing cefepime adsorption in filters used in critically ill patients.Methods: Two filters were used, ST™150 and AV™1000. Adsorption was assessed in two modes, including diafiltration and filtration set to flow rates of from 2.5 to 1 L/h, respectively. Routes of elimination were assessed using NeckEpur® method for 6-h session duration.Results: The mean initial concentration in the 5-L central compartment (CC) in the 10 sessions was 47.7 ± 2.9 mg/L. Using the diafiltration mode, the mean adsorption rates in the ST™150 and AV™1000 were 1.3 ± 2.3% and 19.7 ± 1.2% (n = 3), respectively. Using the filtration mode at 1 L/h, the mean adsorption rates in the ST™150 and AV™1000 were 1.7% (n = 2) and 18.5% (n = 2), respectively.Conclusion: ST™150 filter sequestrated very limited quantities of cefepime. In the diafiltration and filtration modes, AV™1000 sequestered cefepime at about 19%. The adsorption rate seems independent of the flow rate. Further studies would be needed to assess, in particular, the clinical relevance of these results in adults as well as drug adsorption in the pediatric population.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988251356124"},"PeriodicalIF":1.3000,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Artificial Organs","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1177/03913988251356124","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Renal replacement therapy efficiently eliminates cefepime. A published in vitro study concluded to minimal adsorption of cefepime in a polysulfone derived filter. We aimed at assessing cefepime adsorption in filters used in critically ill patients.

Methods: Two filters were used, ST™150 and AV™1000. Adsorption was assessed in two modes, including diafiltration and filtration set to flow rates of from 2.5 to 1 L/h, respectively. Routes of elimination were assessed using NeckEpur^® method for 6-h session duration.

Results: The mean initial concentration in the 5-L central compartment (CC) in the 10 sessions was 47.7 ± 2.9 mg/L. Using the diafiltration mode, the mean adsorption rates in the ST™150 and AV™1000 were 1.3 ± 2.3% and 19.7 ± 1.2% (n = 3), respectively. Using the filtration mode at 1 L/h, the mean adsorption rates in the ST™150 and AV™1000 were 1.7% (n = 2) and 18.5% (n = 2), respectively.

Conclusion: ST™150 filter sequestrated very limited quantities of cefepime. In the diafiltration and filtration modes, AV™1000 sequestered cefepime at about 19%. The adsorption rate seems independent of the flow rate. Further studies would be needed to assess, in particular, the clinical relevance of these results in adults as well as drug adsorption in the pediatric population.

查看原文本刊更多论文

肾替代治疗中使用的过滤器对头孢吡肟吸附的体外评估。

肾脏替代疗法能有效消除头孢吡肟。一项已发表的体外研究表明，聚砜衍生过滤器对头孢吡肟的吸附最小。我们的目的是评估危重患者使用的过滤器对头孢吡肟的吸附。方法：采用ST™150和AV™1000两种滤光器。在两种模式下对吸附进行了评估，分别为过滤和过滤，流速分别为2.5至1 L/h。使用NeckEpur®方法评估6小时疗程的消除途径。结果：10个疗程5-L中央室（CC）平均初始浓度为47.7±2.9 mg/L。采用滤除模式，ST™150和AV™1000的平均吸附率分别为1.3±2.3%和19.7±1.2% （n = 3）。在1 L/h的过滤模式下，ST™150和AV™1000的平均吸附率分别为1.7% （n = 2）和18.5% （n = 2）。结论：ST™150滤池对头孢吡肟的分离量非常有限。在滤过和过滤模式下，AV™1000对头孢吡肟的隔离率约为19%。吸附速率似乎与流速无关。需要进一步的研究来评估，特别是这些结果在成人中的临床相关性以及在儿科人群中的药物吸附。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Artificial Organs 医学-工程：生物医学

CiteScore

3.40

自引率

5.90%

发文量

审稿时长

3 months

期刊介绍： The International Journal of Artificial Organs (IJAO) publishes peer-reviewed research and clinical, experimental and theoretical, contributions to the field of artificial, bioartificial and tissue-engineered organs. The mission of the IJAO is to foster the development and optimization of artificial, bioartificial and tissue-engineered organs, for implantation or use in procedures, to treat functional deficits of all human tissues and organs.