International Journal of Artificial Organs最新文献

{"title":"Impact of continuous renal replacement therapy and Cytosorb on cefiderocol pharmacokinetics: \"One size does not fit all\".","authors":"Gabriella Bottari, Guzzo Isabella, Cecchetti Corrado, Sara Cairoli, Marco Marano, Federica Galaverna, Francesca Stoppa, Emilia Boccieri, Raffaella Labbadia, Andrea Cappoli, Simeoli Raffaele, Bianca Maria Goffredo","doi":"10.1177/03913988251322702","DOIUrl":"https://doi.org/10.1177/03913988251322702","url":null,"abstract":"<p><p>Cefiderocol, a novel broad-spectrum cephalosporin, exhibits promising efficacy against carbapenem-resistant Gram-negative bacteria via a \"Trojan horse\" mechanism. Its pharmacokinetics (PK) and pharmacodynamics (PD) in critically ill patients, particularly under extracorporeal therapies such as Continuous Renal Replacement Therapy (CRRT) and hemoadsorption (HA), remain underexplored. This case report evaluates the PK/PD profile of cefiderocol in a 16-year-old male with relapsed B-cell leukemia, multi-organ failure, and septic shock treated with Continuous Venous-Venous Hemodiafiltration (CVVHDF) and Cytosorb® HA. Cefiderocol clearance and drug removal were monitored using Therapeutic Drug Monitoring (TDM). Data demonstrated that cefiderocol was susceptible to removal during CVVHDF and HA, with variable clearance rates and removal percentages across time points. HA displayed significant cefiderocol removal during the initial 120-180 min, tapering thereafter, while CVVHDF exhibited a fluctuating clearance pattern influenced by effluent rates. Despite achieving PK/PD efficacy targets (C_min/MIC ⩾ 4) in 71.4% of cases, variability was observed. Findings highlight the need for personalized antibiotic dosing in critically ill patients undergoing extracorporeal therapies. Adjustments such as additional dosing during early HA or extended cefiderocol infusion (2-3 h) at shorter intervals (every 6 h) may optimize therapeutic outcomes. These insights underscore the critical role of TDM in ensuring effective PK/PD target attainment, though further research is required to substantiate these preliminary observations.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988251322702"},"PeriodicalIF":1.4,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of carboxyhemoglobin and methemoglobin levels with hemolysis during extracorporeal membrane oxygenation.","authors":"Tsubasa Yoshida, Satoshi Kimura, Takanobu Sakura, Tatsuhiko Shimizu, Tomoyuki Kanazawa, Kazuyoshi Shimizu, Tatsuo Iwasaki, Hiroshi Morimatsu","doi":"10.1177/03913988251326398","DOIUrl":"https://doi.org/10.1177/03913988251326398","url":null,"abstract":"<p><strong>Introduction: </strong>Hemolysis, characterized by increased carboxyhemoglobin (COHb) and methemoglobin (MetHb) levels, is a complication of extracorporeal membrane oxygenation (ECMO).</p><p><strong>Methods: </strong>This prospective single-center study aimed to investigate the correlation between COHb and MetHb levels and hemolysis during ECMO. This study included 32 patients requiring ECMO for circulatory or respiratory failure. Plasma-free hemoglobin (pfHb), COHb, and MetHb levels were measured simultaneously within 6 h of ECMO induction, daily during ECMO, within 6 h after decannulation, and 2 days after decannulation unless death occurred before. Patients were classified into hemolysis and non-hemolysis groups based on whether the maximum pfHb level during ECMO was ⩾50 mg/dL.</p><p><strong>Results: </strong>No significant difference in maximum COHb levels during ECMO (COHb_ECMO) was observed between the hemolysis and non-hemolysis groups (2.15% [interquartile range (IQR) = 1.83, 2.60] vs 1.65% [IQR = 1.40, 2.10], <i>p</i> = 0.159). However, maximum MetHb levels during ECMO (MetHb_ECMO) were significantly higher in the hemolysis group (1.35% [IQR = 1.12, 1.78] vs 1.10% [IQR = 0.90, 1.37], <i>p</i> = 0.045). The Spearman's correlation coefficients for COHb_ECMO and MetHb_ECMO were 0.39 (95% confidence interval [CI] = 0.456-0.649) and 0.66 (95% CI = 0.404-0.820), respectively.</p><p><strong>Conclusion: </strong>Elevated MetHb levels in patients undergoing ECMO may be associated with hemolysis.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988251326398"},"PeriodicalIF":1.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteogenic differentiation of rat bone mesenchymal stem cells cultured on bioceramic scaffolds (alpha-TCP-RL, SiTCP-RL, and SiTCP-RC).","authors":"Ana A Rodrigues, Nilza A Batista, Cecília Ac Zavaglia, Ana Leticia P Rubello, Arnaldo R Santos, William D Belangero","doi":"10.1177/03913988251323395","DOIUrl":"https://doi.org/10.1177/03913988251323395","url":null,"abstract":"<p><p>We evaluated the viability of Vero and the osteogenic differentiation potential of mesenchymal stem cells (MSCs) cells cultured on alpha-TCP-RL, SiTCP-RL, and SiTCP-RC bioceramic scaffolds. Viability of Vero cells and MSCs were evaluated by the MTT assay. The morphological pattern of the two cell types was analyzed by SEM. The functional activity of MSCs was evaluated by a cytochemical assay and osteogenic differentiation by Alizarin red staining and ALP activity. In the MTT assay, Vero cells showed high activity in the extract cytotoxicity test but low activity in the direct contact test. SEM morphological analysis showed the spread of cells with irregular and flattened morphology on the different substrates. We found a smaller number of MSCs than Vero cells on the ceramics. The cytochemical analysis revealed MSCs indicating high functional activity. We observed signs of osteogenic differentiation of MSCs by quantification of ALP activity and formation of mineralized organic matrix.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988251323395"},"PeriodicalIF":1.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post COVID symptom burden in patients supported with extracorporeal membrane oxygenation: A prospective 2-year follow-up analysis.","authors":"Rayan Cheaban, Anna L Rogge, Katharina E Schaeper, Nicole Weinrautner, Thomas Kirschning, Frank Bruenger, Maria R Serrano, Markus Rudloff, Iris Barndt, Marcus Wiemer, René Schramm, Jan F Gummert, Sabina Pw Guenther","doi":"10.1177/03913988251322710","DOIUrl":"https://doi.org/10.1177/03913988251322710","url":null,"abstract":"<p><strong>Objectives: </strong>A systematic characterization of the long-term sequelae after the severest form of COVID-19 requiring ECMO-therapy is lacking. Here, we present 2-year follow-up data of COVID-19 ECMO survivors, and analyze the cardiopulmonary, neurocognitive, psychological, and functional status, plus health-related quality of life (HRQL).</p><p><strong>Methods: </strong>From 04/2020 to 09/2021, 60 COVID patients were supported with ECMO. Survival to discharge was 40.0% (<i>n</i> = 24), and 6-month survival was 33.3% (<i>n</i> = 20). Follow-ups were performed via phone and mail using validated tools. Six-month outcomes have been published before.</p><p><strong>Results: </strong>At 2 years, 20 patients were alive. N = 19 agreed to participate in this study (median age 57.0 (45.0-63.0) years, 21.1% female). The cardiopulmonary status was satisfactory (78.9% in NYHA level I-II). Altogether, 84.2% were vastly independent in daily life. However, 47.4% still showed cognitive impairment, 21.1% moderate, 15.8% severe depression, and 15.8% posttraumatic stress disorder symptoms. HRQL subscale results were similar to 6 months, but patients self-rated their overall health significantly better (70.0% (50.0%-80.0%) vs 50.0% (30.0%-80.0%), <i>p</i> = 0.04). The number of patients working was increasing. Social life remained markedly affected.</p><p><strong>Conclusions: </strong>Two-year outcomes in COVID-19 ECMO patients were stable to improving as compared to 6-month results. However, long-term impairments affected all aspects of life. Long COVID specifically, and post ECMO sequelae in general need to be characterized further to enable maximum recovery.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988251322710"},"PeriodicalIF":1.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the mechanical properties of bond strength in adhesive systems bonded to HCR silicone facial.","authors":"Marcelo Coelho Goiato, Nayla Caroline Santos Yamamoto, Clóvis Lamartine de Moraes Melo Neto, Emily Vivianne Freitas da Silva, Fernanda Pereira de Caxias, Daniela Micheline Dos Santos","doi":"10.1177/03913988251325680","DOIUrl":"https://doi.org/10.1177/03913988251325680","url":null,"abstract":"<p><strong>Objective: </strong>Therefore, this study aimed to evaluate the maximum displacement resistance of silicone samples adhered to human skin using different adhesives. For this purpose, colorless silicone samples (A-4530-HCRA Silicone Gum HCR) pigmented with Functional Intrinsic II Silicone Coloring System were made and distributed into five groups (1. SA specific adhesive for maxillofacial prostheses: Drying Adhesive; 2. GHPG hair prosthesis glue; 3.GFEG semi-permanent fake eyelash glue; 4. GCLG colorless liquid glue; and 5. GDAT and denture adhesive tape). Four times were used, 30 min (<i>T</i>0), 240 (<i>T</i>1), and 480 min (<i>T</i>2) after the samples were adhered to the volunteer's forearm.</p><p><strong>Results: </strong>The maximum silicone displacement force was greater for the Hair Prosthesis Glue group (GHPG) in the <i>T</i>0 and <i>T</i>2 periods.</p><p><strong>Conclusion: </strong>The results show that hair glue (GHPG) would be an alternative option for use in maxillofacial prostheses and denture adhesive tape (GDAT) showed a lack of effective adhesion.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988251325680"},"PeriodicalIF":1.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between systemic coagulation-inflammation index and proximal upper-extremity arteriovenous graft thrombosis in hemodialysis patients.","authors":"Demir Cetintas, Hakan Guven","doi":"10.1177/03913988251323733","DOIUrl":"https://doi.org/10.1177/03913988251323733","url":null,"abstract":"<p><strong>Introduction: </strong>To the best of our knowledge, the potential predictive association between systemic coagulation-inflammation index (SCI) and arteriovenous graft (AVG) thrombosis following proximal upper-extremity AVG surgery has not yet been investigated. Thus, in this study, we investigated the predictive value of SCI on postoperative early-term AVG thrombosis in patients undergoing proximal upper-extremity AVG surgery for hemodialysis access.</p><p><strong>Methods: </strong>A total of 118 hemodialysis patients undergoing proximal upper-extremity AVG surgery were enrolled to this retrospective observational cohort study. The patients were categorized into two groups in accordance with whether postoperative early-term AVG thrombosis developed; as thrombosed AVG group (<i>n</i> = 37) and non-thrombosed AVG group (<i>n</i> = 81). Basic clinical features and laboratory test results of the patients were recorded and compared between the groups.</p><p><strong>Results: </strong>Patients in thrombosed AVG group were significantly older than those in non-thrombosed AVG group. The mean WBC and neutrophil counts were significantly lower whereas the mean fibrinogen and median SCI values were significantly higher in thrombosed AVG group compared to non-thrombosed AVG group. In terms of other basic clinical features and laboratory tests, there were no significant differences between both groups in univariate analyses. In multivariate logistic regression analysis, only age and SCI maintained their statistical significance and thus were accepted as independent predictors of AVG thrombosis. ROC analysis demonstrated that SCI of 47 g/L constituted the optimum cut-off value with 94.6% sensitivity and 88.9% specificity rates in predicting AVG thrombosis.</p><p><strong>Conclusion: </strong>Our study revealed for the first time in the literature that SCI independently predicted postoperative early-term AVG thrombosis in hemodialysis patients undergoing proximal upper-extremity AVG surgery.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988251323733"},"PeriodicalIF":1.4,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Veno-arterial ECMO support for severe amlodipine toxicity combined with cardiogenic shock: A case report.","authors":"Yi Sun, Tingting Wang, Jiading Xia, Liwei Hua, Shuchen Cao, Kun Zhang","doi":"10.1177/03913988251321620","DOIUrl":"https://doi.org/10.1177/03913988251321620","url":null,"abstract":"<p><strong>Introduction: </strong>Management of severe circulatory collapse in the setting of amlodipine toxicity can be challenging. High doses of vasopressors and conventional therapies fail to improve hemodynamics, resulting in the use of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) to treat severe cardiogenic shock and peripheral vasodilatation. Therapeutic plasma exchange (TPE), which helps remove plasma protein-bound toxins and significantly reduces mortality, may be a useful adjunct to invasive hemodynamic support in severe cases of amlodipine poisoning.</p><p><strong>Case summary: </strong>A 32-year-old female with a history of intentional consumption of ninety 5-mg amlodipine tablets (totaling 450 mg) was admitted to our intensive care unit (ICU) after 3 h. Her amlodipine serum concentration was 147 ng/mL. She presented with cardiogenic shock and fatal vasoplegia and received VA-ECMO and TPE. The patient was weaned off ECMO after 4 days and discharged home on Day 10 of hospitalization.</p><p><strong>Conclusion: </strong>Amlodipine toxicity can result in severe cardiac failure with circulatory collapse. We describe the case of a patient with cardiovascular collapse who successfully bridged to recovery from refractory shock secondary to severe amlodipine toxicity as a result of ECMO and TPE treatment.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988251321620"},"PeriodicalIF":1.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal design and analysis of a novel magnetic drive blood pump.","authors":"Zina Zhu, Yupeng Zhang, Renyu Wan, Peng Wu, Guohua Cui","doi":"10.1177/03913988251316678","DOIUrl":"https://doi.org/10.1177/03913988251316678","url":null,"abstract":"<p><p>Utilizing magnetic coupling to drive the artificial heart blood pump in a non-contact and wireless manner offers a viable solution that can effectively avoid problems such as percutaneous lead infection. However, the existing magnetic drive blood pumps have problems such as low utilization efficiency and limited transmission torque due to significant leakage of permanent magnets. To address these limitations, this paper introduces a magnetic modulation-based magnetic drive blood pump, which uses salient pole iron sheets to modulate the magnetic field generated by permanent magnets, thereby minimizing leakage and enhancing the efficiency of permanent magnet utilization. Through finite element analysis of electromagnetic fields, the magnetic circuit structure of the magnetic modulation type magnetic drive blood pump is optimized. Additionally, the influence of the air gap distance of the magnetic drive blood pump on transmission performance is analyzed. Finally, a comprehensive experimental setup for blood pump is developed. By measuring the load torque and spatial magnetic flux density parameters of the magnetic drive blood pump and comparing them to the simulation outcomes, the effectiveness of the proposed magnetic modulation type blood pump is verified.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988251316678"},"PeriodicalIF":1.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of surface coatings on endothelialization and biofilm in PTFE vascular grafts.","authors":"Muhammet Hüseyin Erkan, Mehmet Boğa, Hanife Salih, Emin Barbarus, Ömer Faruk Rahman, Sarhan Sakarya","doi":"10.1177/03913988251316438","DOIUrl":"https://doi.org/10.1177/03913988251316438","url":null,"abstract":"<p><p>Polytetrafluoroethylene (PTFE) grafts are of great importance for vascular surgery and many methods have been developed to improve their biocompatibility. The most important of these methods is the coating of the inner surfaces of the grafts. In this study, the effects of surface coatings used in vascular grafts on endothelialization and bacterial biofilm formation were investigated. Three different PTFE graft types, heparin coated, carbon coated and uncoated, were compared. HUVEC cell culture was used for endothelialization experiments and Staphylococcus aureus strain was used for biofilm formation. Endothelialization was evaluated by inverted microscopy and scanning electron microscopy (SEM). Heparin-coated grafts showed more biofilm formation than other graft types (<i>p</i> < 0.01). Moderate biofilm formation was observed in carbon-coated grafts (<i>p</i> < 0.05). When evaluating endothelialization, heparin-coated grafts showed more cell adhesion in the first days, but lagged behind the other graft types in the following days. Carbon-coated grafts showed more endothelial cell proliferation in the long term. While biofilm formation was high in heparin-coated grafts, carbon-coated grafts provided better endothelialization. Our study showed that the coating of PTFE grafts significantly affects biocompatibility and infection risk.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988251316438"},"PeriodicalIF":1.4,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Collagen as a biomaterial for skin wound healing: From structural characteristics to the production of devices for tissue engineering.","authors":"Luciana P Giorno, Sonia M Malmonge, Arnaldo R Santos","doi":"10.1177/03913988251316437","DOIUrl":"10.1177/03913988251316437","url":null,"abstract":"<p><p>Collagen is an abundant component in the human body and plays a fundamental role in the integrity and function of various tissues, including skin, bones, joints, and connective tissues. This natural polymer also contributes to physiological balance and individual health. Within this context, this article reviews the structure of collagen, describing intrinsic characteristics that range from its molecular composition to its organization into bundles. Additionally, the review highlights some of the applications of collagen in tissue engineering, particularly its mimicry of the skin's extracellular matrix. For this review, searches were performed in PubMed, Scopus, and Web of Sciences. The inclusion criteria were established based on the relevance of the studies for the objectives of the review and methodological quality. After selection of the articles, a critical analysis of their content was conducted and the information was synthesized and presented concisely. Analysis of the properties of collagen revealed its key importance for the design of bioactive materials in regenerative applications. However, challenges such as the need for improvement of the integration of implanted materials and a better understanding of the underlying biological processes remain.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988251316437"},"PeriodicalIF":1.4,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}