International Journal of Artificial Organs最新文献

Reoperation for the implantation of Corheart 6 biventricular assist devices due to severe right ventricular failure and aortic regurgitation following left ventricular assist device implantation. 由于左心室辅助装置植入后出现严重的右心室衰竭和主动脉反流，再次手术植入Corheart 6双心室辅助装置。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2025-07-23 DOI: 10.1177/03913988251351122

Yafeng Liu, Li Yin, Yiming Liu, Liqiong Xiao, Hongwei Shi, Xiaochun Song, Zhibing Qiu, Xin Chen

{"title":"Reoperation for the implantation of Corheart 6 biventricular assist devices due to severe right ventricular failure and aortic regurgitation following left ventricular assist device implantation.","authors":"Yafeng Liu, Li Yin, Yiming Liu, Liqiong Xiao, Hongwei Shi, Xiaochun Song, Zhibing Qiu, Xin Chen","doi":"10.1177/03913988251351122","DOIUrl":"https://doi.org/10.1177/03913988251351122","url":null,"abstract":"Background: We present the case of a 68-year-old patient who underwent secondary thoracotomy, implantation of a continuous-flow ventricular assist device (VAD) in a biventricular configuration, and aortic valve replacement (AVR) 2 years after receiving a continuous-flow left ventricular assist device (LVAD) and coronary artery bypass grafting (CABG), due to right ventricular failure, moderate aortic insufficiency, and damage to the original LVAD device cable.Case report: The patient initially received a Corheart 6 LVAD, CABG, and tricuspid annuloplasty due to end-stage heart failure resulting from ischemic cardiomyopathy and severe tricuspid regurgitation. Following the surgery, the patient was discharged with favorable outcomes. However, 2 years later, the patient was readmitted with severe right heart failure. Given the current shortage of heart donors, the decision was made to implant a Corheart 6 biventricular VAD (BiVAD) as destination therapy.Conclusion: Severe right ventricular failure is a well-recognized complication following continuous-flow LVAD implantation. In this case, it was successfully managed with BiVADs as destination therapy for this high-risk patient.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988251351122"},"PeriodicalIF":1.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Red blood cell damage during normothermic liver perfusion: A hidden barrier to graft assessment? 常温肝灌注时红细胞损伤：移植评估的隐藏障碍？

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2025-07-15 DOI: 10.1177/03913988251351513

Andres Rivera, Ignacio Fernandez-Lopez, Juan F Del Canizo

{"title":"Red blood cell damage during normothermic liver perfusion: A hidden barrier to graft assessment?","authors":"Andres Rivera, Ignacio Fernandez-Lopez, Juan F Del Canizo","doi":"10.1177/03913988251351513","DOIUrl":"https://doi.org/10.1177/03913988251351513","url":null,"abstract":"Background: Normothermic machine for liver perfusion (NMP) has emerged as a promising technique for dynamic preservation and functional assessment of liver grafts. However, red blood cell hemolysis is a frequently underestimated complication that may impair the interpretation of viability metrics. This study aims to determine the impact of rising free hemoglobin levels (fHb) on hepatic perfusion during NMP.Materials and methods: Fifteen healthy female porcine livers were perfused for 18 hours using a NMP circuit primed with autologous whole blood. Hourly measurements included fHb levels, total hepatic, portal, and arterial flows, as well as biochemical parameters. Correlations between fHb and perfusion parameters were evaluated using Spearman's rank test.Results: All livers were successfully perfused for 18 h. Free hemoglobin levels progressively increased over time. Significant inverse correlations were observed between fHb and portal vein flow (ρ = -0.772) and total hepatic flow (ρ = -0.650). Among biochemical markers, only GGT and CK showed positive correlations with fHb.Conclusion: Progressive hemolysis during NMP is associated with impaired hepatic perfusion, affecting the portal system, and correlates with selective biochemical injury markers. These findings highlight the need for systematic monitoring of fHb in NMP protocols to ensure viability assessment and optimize graft preservation.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988251351513"},"PeriodicalIF":1.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determinants of aortic pulse wave velocity adjusted for age in peritoneal dialysis patients. 腹透患者年龄调整主动脉脉波速度的决定因素。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2025-07-09 DOI: 10.1177/03913988251355085

Jamie Beverstock, Andrew Davenport

{"title":"Determinants of aortic pulse wave velocity adjusted for age in peritoneal dialysis patients.","authors":"Jamie Beverstock, Andrew Davenport","doi":"10.1177/03913988251355085","DOIUrl":"https://doi.org/10.1177/03913988251355085","url":null,"abstract":"Background: Pulse wave velocity (PWV) is a recognised risk factor for mortality and cardiovascular disease in peritoneal dialysis (PD) patients. However, debate continues as to which factors increase PWV. We reviewed the effect of volume overload and calcium balance on PWV.Methods: Aortic PWV (aoPWV) was measured in PD patients attending for routine assessments of peritoneal membrane function, with assessments of extracellular water with bioimpedance and cardiac biomarkers.Results: A total of 122 patients were included (55.6% male; mean age = 64.8 ± 15.3 years; 36.1% diabetic; median dialysis vintage = 19.5 (7.9-37.3) months; weight = 72.7 ± 16.4 kg; mean aoPWV = 9.9 ± 2.2 m/s). Patients with elevated aoPWV (>2 standard deviations above the age-adjusted mean) were compared to those within the expected range. We found that increased adjusted aoPWV was associated on receiver operator curves (ROC) with younger age (ROC = 0.15, p < 0.001), higher sodium removal (ROC = 0.69, p = 0.002), greater use of hypertonic dialysates (ROC = 0.68, p = 0.04), higher PD ultrafiltration (ROC = 0.68, p = 0.005) and elevated N-terminal probrain natriuretic peptide (NTproBNP; ROC = 0.62, p = 0.38), but with lower residual kidney function (KtVurine; 0.34, p = 0.023). On multivariable analysis, both younger age (OR = 0.90; 95% confidence interval (CI) = 0.86-0.95; p < 0.001) and higher log-transformed NTproBNP (OR = 3.24; 95% CI = 1.05-9.96; p = 0.04) remained independently associated with a raised adjusted aoPWV.Conclusions: This study demonstrates that, after adjusting for age, elevated aoPWV is associated with an increased NTproBNP, suggesting that volume overload increases arterial stiffness. These results reinforce the importance of improving volume control in PD patients to reduce cardiovascular risk.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988251355085"},"PeriodicalIF":1.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organ-on-chip models for reconstructive tissue engineering: An evolutionary plastic surgery advance. 用于重建组织工程的器官芯片模型：整形外科的进化进展。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2025-07-06 DOI: 10.1177/03913988251355075

Muhammad Talha, Maliha Khalid

引用次数: 0

Development of a novel bifunctional and volume-stable soft tissue substitute for peri-implant soft tissue and bone integration. 一种新型的双功能和体积稳定的软组织替代品，用于种植体周围软组织和骨整合。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2025-07-06 DOI: 10.1177/03913988251355095

Krittaphat Fusang, Prisana Pripatnanont, Jirut Meesane, Jutakan Thonglam, Naruporn Monmaturapoj

{"title":"Development of a novel bifunctional and volume-stable soft tissue substitute for peri-implant soft tissue and bone integration.","authors":"Krittaphat Fusang, Prisana Pripatnanont, Jirut Meesane, Jutakan Thonglam, Naruporn Monmaturapoj","doi":"10.1177/03913988251355095","DOIUrl":"https://doi.org/10.1177/03913988251355095","url":null,"abstract":"The collagen-based soft tissue substitutes are popularly used instead of autogenous connective tissue grafts (CTG). However, it has some drawbacks, such as rapid degradation and compromised volume stability. The novel bifunctional and volume-stable soft tissue substitute (BVSS), based on polyvinyl alcohol (PVA), biphasic calcium phosphate (BCP), and fish collagen was developed to overcome those mentioned problems. The physicochemical and mechanical properties were characterized and compared using scanning electron microscopy (SEM), degradation and swelling behavior, Fourier transform infrared spectroscopy(FT-IR), differential scanning calorimetry (DSC), and tensile testing, respectively. The biocompatibility was evaluated with fibroblast and osteoblast cells. The SEM images showed a rough and porous surface with interconnected porous structures. The 3% PVA-based scaffolds showed a suitable degradation rate in collagenase (40%-50%), more than 5% PVA (20%-30%) in 8 weeks. All prepared BVSS presented high water absorption rates. The 5% PVA-based scaffolds showed higher tensile strength than the 3% PVA-based scaffolds. The 3% 8:2 and 5% 8:2 demonstrated good cell proliferation and adhesion of both fibroblast and osteoblast cells on the scaffold. The prepared BVSS is compatible with hard and soft tissues and maintains a volume-stable character, making it ideal as a bifunctional peri-implant tissue scaffold.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988251355095"},"PeriodicalIF":1.4,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical efficacy of acupoint massage combined with auricular points plaster therapy on sleep and quality of life in patients undergoing maintenance hemodialysis. 穴位按摩联合耳穴贴敷对维持性血液透析患者睡眠及生活质量的影响。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2025-07-06 DOI: 10.1177/03913988251355087

Bihong Lai, Li Shen, Xiaocui Guo, Xia Shen, Lin Zhao, Shuiying Ye, Dongchi Zhou, Xiaowen Tang, Jindong Tong

{"title":"Clinical efficacy of acupoint massage combined with auricular points plaster therapy on sleep and quality of life in patients undergoing maintenance hemodialysis.","authors":"Bihong Lai, Li Shen, Xiaocui Guo, Xia Shen, Lin Zhao, Shuiying Ye, Dongchi Zhou, Xiaowen Tang, Jindong Tong","doi":"10.1177/03913988251355087","DOIUrl":"https://doi.org/10.1177/03913988251355087","url":null,"abstract":"Objective: To explore the clinical efficacy of acupoint massage combined with auricular points plaster therapy on sleep quality and quality of life in patients undergoing Maintenance Hemodialysis (MHD).Methods: One hundred and twenty insomnia patients undergoing MHD from January 2022 to December 2024 were selected and randomly divided into an observation group (n = 60) and a control group (n = 60). The control group was given conventional treatment, while the observation group received acupoint massage combined with auricular points plaster therapy in addition to conventional treatment, with an intervention period of 4 weeks. After 4 weeks, the pre- and post-treatment Pittsburgh Sleep Quality Index (PSQI) and World Health Organization Quality of Life-BREF (WHOQOL-BREF) scores were compared, along with the Newcastle Nursing Satisfaction Scale (NSNS) scores between the two groups.Results: After 4 weeks of intervention, the observation group showed significant efficacy in TCM syndrome differentiation, with a response rate of 80.0%. The total PSQI and WHOQOL scores decreased (p < 0.05), with an overall response rate of 90.0%. Meanwhile, after 4 weeks of intervention, the observation group demonstrated significant efficacy in TCM syndrome differentiation after intervention for 4 weeks, with an overall response rate of 90.0%. Additionally, the PSQI score remarkably decreased (p < 0.05) and the WHOQOL-BREF score substantially increased (p < 0.05), with the NSNS score being markedly higher than that of the control group (p < 0.05).Conclusion: The selection of acupoints for acupoint massage combined with auricular points plaster therapy can improve sleep quality, quality of life, and nursing satisfaction in patients undergoing MHD.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988251355087"},"PeriodicalIF":1.4,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyethylene and silicone insoles for patient-specific conditions using computational and experimental methods. 聚乙烯和硅胶鞋垫的病人特定条件下使用计算和实验方法。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2025-07-02 DOI: 10.1177/03913988251355080

Hinpetch Daungsupawong, Viroj Wiwanitkit

引用次数: 0

Establishment of liver cancer disease model via normothermic machine perfusion. 恒温机灌注肝癌模型的建立。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2025-06-27 DOI: 10.1177/03913988251351519

Mingxi Zhang, Ming Liu, Youyuan Chen, Yefu Li, Qiang Zhao, Xiaoshun He

{"title":"Establishment of liver cancer disease model via normothermic machine perfusion.","authors":"Mingxi Zhang, Ming Liu, Youyuan Chen, Yefu Li, Qiang Zhao, Xiaoshun He","doi":"10.1177/03913988251351519","DOIUrl":"https://doi.org/10.1177/03913988251351519","url":null,"abstract":"Purpose: To date, there are no effective therapeutic strategies for hepatocellular carcinoma (HCC). Traditionally, researches on HCC were carried out using hepatocellular carcinoma cells, organoids, and animal models. However, these models cannot accurately replicate the pathophysiological conditions underlying the onset and progression of human HCC. Therefore, more effective disease models are needed to study HCC.Methods: Ten disease livers from HCC patients who underwent transplantation were subjected to normothermic machine perfusion (NMP) via the hepatic artery and portal vein in vitro. Perfusion parameters, blood gas levels, and contrast-enhanced ultrasound (CEUS) were continuously monitored to assess alterations in tumor activity. RNA sequencing (RNA-seq) and next-generation sequencing (NGS) of circulating tumor DNA (ctDNA) were employed to assess the preservation of hepatic tissue integrity and tumor mutational profiles during in vitro perfusion. Oxaliplatin +5-FU was used to conduct the liver cancer treatment research.Results: Normothermic machine perfusion successfully maintained liver survival for 92 h in vitro. Contrast-enhanced ultrasound can be used to assess alterations in tumor and liver activity during normothermic machine perfusion. The sequencing analysis revealed that normothermic machine perfusion (NMP) effectively preserved hepatic tissue integrity while retaining tumor genomic stability. The normothermic machine perfusion model of HCC can be used for the study of anti-cancer therapy.Conclusions: Contrast-enhanced ultrasound can monitor alterations in tumor and liver activity, while normothermic machine perfusion can sustain the long-term survival of the liver in vitro, thus maintaining normal tumor characteristics. Therefore, this model provides a novel approach for studying tumor therapy.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988251351519"},"PeriodicalIF":1.4,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of the influence of blade angle distribution on hemodynamic and hemocompatibility performance in a miniature axial blood pump. 叶片角度分布对小型轴向血泵血流动力学和血液相容性影响的研究。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2025-06-25 DOI: 10.1177/03913988251349000

Zhi-Peng He, Shen Lv, Guang-Mao Liu, Sheng-Shou Hu

{"title":"Study of the influence of blade angle distribution on hemodynamic and hemocompatibility performance in a miniature axial blood pump.","authors":"Zhi-Peng He, Shen Lv, Guang-Mao Liu, Sheng-Shou Hu","doi":"10.1177/03913988251349000","DOIUrl":"https://doi.org/10.1177/03913988251349000","url":null,"abstract":"High shear stress and turbulence in a miniature axial blood pump are affected by the pump's blade structure. which impacts the pump's hemodynamics and hemocompatibility performance. This study designed blades for a miniature axial blood pump via computational fluid dynamics (CFD). The optimal blade angle distribution must improve hemodynamic and hemocompatibility performance under the designed operating conditions (45,000 rpm rotational speed and 3 L/min flow rate). First, the blade inlet angles β1 were varied from -100° to -220°. Second, using the optimal β1, the blade angle distribution was changed by setting different curvatures at different curvature positions. Finally, the relationships among blade angle distribution parameters and hemodynamic, hemolysis, and thrombosis risk were analyzed. The results indicated that angle distribution should avoid positive curvature, and that \"the absolute value of negative curvature percentage should increase progressively with the increasing of curvature position.\" Compared with the original impeller, the CFD and experimental results revealed an optimized impeller with a 17.4% increase in pressure head, a 2.1% increase in hydraulic efficiency, an 8.4% decrease in hemolysis index, and a 5.3% decrease in volume-averaged scaled activated platelet concentration. CFD-guided blade angle optimization can improve the hemodynamic and hemocompatibility performance of miniature axial blood pumps.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988251349000"},"PeriodicalIF":1.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Left ventricular assist device exchanges: A safe and effective strategy in the era of limited organ availability. 左心室辅助装置交换：在器官供应有限的时代一种安全有效的策略。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2025-06-25 DOI: 10.1177/03913988251351116

Nandini Nair, Kenny Nguyen, Dongping Du, Aditya Mahesh, Behzad Soleimani, Balakrishnan Mahesh

{"title":"Left ventricular assist device exchanges: A safe and effective strategy in the era of limited organ availability.","authors":"Nandini Nair, Kenny Nguyen, Dongping Du, Aditya Mahesh, Behzad Soleimani, Balakrishnan Mahesh","doi":"10.1177/03913988251351116","DOIUrl":"https://doi.org/10.1177/03913988251351116","url":null,"abstract":"Background: Ongoing donor-organ shortage has limited transplantation making LVADs an effective alternative therapy for patients with end-stage heart failure. When LVAD-associated complications arise device exchange is a feasible and safe alternative. This study addresses the factors that impact survival post-LVAD exchange.Methods: Our decoded database was constructed retrospectively. Surgical details, device features, and re-intervention information were studied. The primary outcome was mortality. Kaplan-Meier estimators were used for post-pump exchange survival analysis. Pairwise log-rank tests compare the survivals between different groups within each variable. p-Value <0.05 was considered significant. Backward-stepwise regression was used to construct the multivariable model using a subset of variables, retaining only variables with a p-value <0.1. Hazard ratios, their 95% confidence intervals, and p-values of the significant variables were reported.Results: Analysis of factors impacting survival post-pump exchange study showed a poor survival probability of only primary midline-sternotomy/redo (p = 0.005). Multivariable analysis showed that bridging with ECMO was protective with a hazard ratio of 0.16 (0.03-0.86, p = 0.03).Conclusions: The overall survival probability is 50% at 4 years post-pump exchange. This study highlights the differences in post-exchange outcomes depending on the device types and surgical approaches used. LVAD exchange for device-related complications can be performed in high-risk patients as a viable alternative to heart transplantation in the setting of the current heart allocation prioritization systems.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988251351116"},"PeriodicalIF":1.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0