International Journal of Artificial Organs最新文献

{"title":"Who should make the decision for renal replacement therapy?","authors":"Edip Erkuş, Rojda Kotan, Doğan Nasır Binici","doi":"10.1177/03913988251323758","DOIUrl":"https://doi.org/10.1177/03913988251323758","url":null,"abstract":"<p><strong>Introduction: </strong>In this study, we aimed to evaluate cognitive functions in Stage 4 and 5 CKD patients using the Montreal Cognitive Assessment (MoCA) Scale, which objectively assesses cognitive dysfunction and various cognitive functions, and to compare them with a control group with normal kidney functions.</p><p><strong>Methods: </strong>All participants in our case-control study were administered the Montreal Cognitive Assessment (MoCA) Test, and total scores, subscale scores, and the presence of cognitive dysfunction were recorded.</p><p><strong>Results: </strong>When the groups were compared in terms of cognitive dysfunction (CD), 12.9% of the control group and 37.1% of the case group were found to have CD, which was statistically significant. When the groups were compared in terms of data and scale scores, the visual construction subscale score, naming, delayed recall subscale score, and total MoCA score were found to be significantly lower in the case group compared to the control group.</p><p><strong>Conclusion: </strong>Our study is the first to use the MoCA test with the correct reference range. The significant impairment observed in the cognitive functions of patients with advanced-stage CKD in our study suggests that the decision for renal replacement therapy should not be made by the patient alone, as it may be incorrect.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988251323758"},"PeriodicalIF":1.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to \"Comparison of the use of standard heparin and 0.9% saline as lock solution in hemodialysis catheter: Importance of closure technique.\"","authors":"Daniele Privitera, Davide Giustivi","doi":"10.1177/03913988251322691","DOIUrl":"https://doi.org/10.1177/03913988251322691","url":null,"abstract":"","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988251322691"},"PeriodicalIF":1.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply \"Comparison of the use of standard heparin and 0.9% saline as lock solution in hemodialysis catheters\".","authors":"Fatih Ergül","doi":"10.1177/03913988251325339","DOIUrl":"https://doi.org/10.1177/03913988251325339","url":null,"abstract":"","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988251325339"},"PeriodicalIF":1.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of carboxyhemoglobin and methemoglobin levels with hemolysis during extracorporeal membrane oxygenation.","authors":"Tsubasa Yoshida, Satoshi Kimura, Takanobu Sakura, Tatsuhiko Shimizu, Tomoyuki Kanazawa, Kazuyoshi Shimizu, Tatsuo Iwasaki, Hiroshi Morimatsu","doi":"10.1177/03913988251326398","DOIUrl":"https://doi.org/10.1177/03913988251326398","url":null,"abstract":"<p><strong>Introduction: </strong>Hemolysis, characterized by increased carboxyhemoglobin (COHb) and methemoglobin (MetHb) levels, is a complication of extracorporeal membrane oxygenation (ECMO).</p><p><strong>Methods: </strong>This prospective single-center study aimed to investigate the correlation between COHb and MetHb levels and hemolysis during ECMO. This study included 32 patients requiring ECMO for circulatory or respiratory failure. Plasma-free hemoglobin (pfHb), COHb, and MetHb levels were measured simultaneously within 6 h of ECMO induction, daily during ECMO, within 6 h after decannulation, and 2 days after decannulation unless death occurred before. Patients were classified into hemolysis and non-hemolysis groups based on whether the maximum pfHb level during ECMO was ⩾50 mg/dL.</p><p><strong>Results: </strong>No significant difference in maximum COHb levels during ECMO (COHb_ECMO) was observed between the hemolysis and non-hemolysis groups (2.15% [interquartile range (IQR) = 1.83, 2.60] vs 1.65% [IQR = 1.40, 2.10], <i>p</i> = 0.159). However, maximum MetHb levels during ECMO (MetHb_ECMO) were significantly higher in the hemolysis group (1.35% [IQR = 1.12, 1.78] vs 1.10% [IQR = 0.90, 1.37], <i>p</i> = 0.045). The Spearman's correlation coefficients for COHb_ECMO and MetHb_ECMO were 0.39 (95% confidence interval [CI] = 0.456-0.649) and 0.66 (95% CI = 0.404-0.820), respectively.</p><p><strong>Conclusion: </strong>Elevated MetHb levels in patients undergoing ECMO may be associated with hemolysis.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988251326398"},"PeriodicalIF":1.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteogenic differentiation of rat bone mesenchymal stem cells cultured on bioceramic scaffolds (alpha-TCP-RL, SiTCP-RL, and SiTCP-RC).","authors":"Ana A Rodrigues, Nilza A Batista, Cecília Ac Zavaglia, Ana Leticia P Rubello, Arnaldo R Santos, William D Belangero","doi":"10.1177/03913988251323395","DOIUrl":"https://doi.org/10.1177/03913988251323395","url":null,"abstract":"<p><p>We evaluated the viability of Vero and the osteogenic differentiation potential of mesenchymal stem cells (MSCs) cells cultured on alpha-TCP-RL, SiTCP-RL, and SiTCP-RC bioceramic scaffolds. Viability of Vero cells and MSCs were evaluated by the MTT assay. The morphological pattern of the two cell types was analyzed by SEM. The functional activity of MSCs was evaluated by a cytochemical assay and osteogenic differentiation by Alizarin red staining and ALP activity. In the MTT assay, Vero cells showed high activity in the extract cytotoxicity test but low activity in the direct contact test. SEM morphological analysis showed the spread of cells with irregular and flattened morphology on the different substrates. We found a smaller number of MSCs than Vero cells on the ceramics. The cytochemical analysis revealed MSCs indicating high functional activity. We observed signs of osteogenic differentiation of MSCs by quantification of ALP activity and formation of mineralized organic matrix.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988251323395"},"PeriodicalIF":1.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the mechanical properties of bond strength in adhesive systems bonded to HCR silicone facial.","authors":"Marcelo Coelho Goiato, Nayla Caroline Santos Yamamoto, Clóvis Lamartine de Moraes Melo Neto, Emily Vivianne Freitas da Silva, Fernanda Pereira de Caxias, Daniela Micheline Dos Santos","doi":"10.1177/03913988251325680","DOIUrl":"https://doi.org/10.1177/03913988251325680","url":null,"abstract":"<p><strong>Objective: </strong>Therefore, this study aimed to evaluate the maximum displacement resistance of silicone samples adhered to human skin using different adhesives. For this purpose, colorless silicone samples (A-4530-HCRA Silicone Gum HCR) pigmented with Functional Intrinsic II Silicone Coloring System were made and distributed into five groups (1. SA specific adhesive for maxillofacial prostheses: Drying Adhesive; 2. GHPG hair prosthesis glue; 3.GFEG semi-permanent fake eyelash glue; 4. GCLG colorless liquid glue; and 5. GDAT and denture adhesive tape). Four times were used, 30 min (<i>T</i>0), 240 (<i>T</i>1), and 480 min (<i>T</i>2) after the samples were adhered to the volunteer's forearm.</p><p><strong>Results: </strong>The maximum silicone displacement force was greater for the Hair Prosthesis Glue group (GHPG) in the <i>T</i>0 and <i>T</i>2 periods.</p><p><strong>Conclusion: </strong>The results show that hair glue (GHPG) would be an alternative option for use in maxillofacial prostheses and denture adhesive tape (GDAT) showed a lack of effective adhesion.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988251325680"},"PeriodicalIF":1.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal design and analysis of a novel magnetic drive blood pump.","authors":"Zina Zhu, Yupeng Zhang, Renyu Wan, Peng Wu, Guohua Cui","doi":"10.1177/03913988251316678","DOIUrl":"10.1177/03913988251316678","url":null,"abstract":"<p><p>Utilizing magnetic coupling to drive the artificial heart blood pump in a non-contact and wireless manner offers a viable solution that can effectively avoid problems such as percutaneous lead infection. However, the existing magnetic drive blood pumps have problems such as low utilization efficiency and limited transmission torque due to significant leakage of permanent magnets. To address these limitations, this paper introduces a magnetic modulation-based magnetic drive blood pump, which uses salient pole iron sheets to modulate the magnetic field generated by permanent magnets, thereby minimizing leakage and enhancing the efficiency of permanent magnet utilization. Through finite element analysis of electromagnetic fields, the magnetic circuit structure of the magnetic modulation type magnetic drive blood pump is optimized. Additionally, the influence of the air gap distance of the magnetic drive blood pump on transmission performance is analyzed. Finally, a comprehensive experimental setup for blood pump is developed. By measuring the load torque and spatial magnetic flux density parameters of the magnetic drive blood pump and comparing them to the simulation outcomes, the effectiveness of the proposed magnetic modulation type blood pump is verified.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"160-169"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of obesity on outcomes in patients receiving extracorporeal membrane oxygenation: A systematic review and meta-analysis.","authors":"Wincy Wing-Sze Ng, Ka-Chun Leung, Rex Wan-Hin Hui, Pauline Yeung Ng, Chun-Wai Ngai, Simon Wai-Ching Sin","doi":"10.1177/03913988251315617","DOIUrl":"10.1177/03913988251315617","url":null,"abstract":"<p><p>Given the growing obesity pandemic, the impact of obesity on outcomes of Extracorporeal Membrane Oxygenation (ECMO) would be increasingly relevant to our daily practise. This meta-analysis aims to evaluate the impact of obesity on ECMO outcomes, integrating the latest evidence. Systematic literature search was conducted from inception until December 2024 on MEDLINE, Embase and the Cochrane Library using the terms 'ECMO', 'obesity', and their related terms. Twenty-eight studies were included from 2013 to 2024, including a total of 74,330 ECMO patients (Mean age 52.84 ± 13.55 years). Obese patients had a similar risk of in-hospital or 30-day mortality when compared to non-obese patients (Risk difference -2%, 95%CI -5% to -1%, <i>I</i>² = 85%, <i>p</i> = 0.25). Subgroup analysis of patients on V-V-ECMO showed a trend towards lower mortality in obese patients which did not reach statistical significance (risk difference -6%, 95%CI -13% to 0%, <i><u>I</u></i>² = 53%, <i>p</i> = 0.06). Subgroup analysis of patients on V-A-ECMO showed significantly higher mortality in obese patients (risk difference 5%, 95%CI 1% to 9%, <i>I</i>² = 54%, <i>p</i> = 0.007). Regarding secondary outcomes, obesity had no significant association with major bleeding or thrombotic complications (Risk difference 0%, 95%CI -1% to 2%, <i>I</i>² = 15%, <i>p</i> = 0.63). Obesity was associated with significantly shorter hospital length-of-stay (Mean difference -2.92 days, 95% CI -5.03 to -0.80, <i>I</i>² = 74%, <i>p</i> = 0.007), but had no impact on ECMO duration (Mean difference 0.35 days, 95%CI -0.03 to 0.74, <i>I</i>² = 41%, <i>p</i> = 0.07). In summary, our meta-analysis showed that obesity was a favourable prognostic factor in V-V-ECMO. However, obesity increased mortality in V-A-ECMO patients. The modality of ECMO support should be taken into consideration when evaluating ECMO candidacy in individual obese patients.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"211-215"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post COVID symptom burden in patients supported with extracorporeal membrane oxygenation: A prospective 2-year follow-up analysis.","authors":"Rayan Cheaban, Anna L Rogge, Katharina E Schaeper, Nicole Weinrautner, Thomas Kirschning, Frank Bruenger, Maria R Serrano, Markus Rudloff, Iris Barndt, Marcus Wiemer, René Schramm, Jan F Gummert, Sabina Pw Guenther","doi":"10.1177/03913988251322710","DOIUrl":"10.1177/03913988251322710","url":null,"abstract":"<p><strong>Objectives: </strong>A systematic characterization of the long-term sequelae after the severest form of COVID-19 requiring ECMO-therapy is lacking. Here, we present 2-year follow-up data of COVID-19 ECMO survivors, and analyze the cardiopulmonary, neurocognitive, psychological, and functional status, plus health-related quality of life (HRQL).</p><p><strong>Methods: </strong>From 04/2020 to 09/2021, 60 COVID patients were supported with ECMO. Survival to discharge was 40.0% (<i>n</i> = 24), and 6-month survival was 33.3% (<i>n</i> = 20). Follow-ups were performed via phone and mail using validated tools. Six-month outcomes have been published before.</p><p><strong>Results: </strong>At 2 years, 20 patients were alive. N = 19 agreed to participate in this study (median age 57.0 (45.0-63.0) years, 21.1% female). The cardiopulmonary status was satisfactory (78.9% in NYHA level I-II). Altogether, 84.2% were vastly independent in daily life. However, 47.4% still showed cognitive impairment, 21.1% moderate, 15.8% severe depression, and 15.8% posttraumatic stress disorder symptoms. HRQL subscale results were similar to 6 months, but patients self-rated their overall health significantly better (70.0% (50.0%-80.0%) vs 50.0% (30.0%-80.0%), <i>p</i> = 0.04). The number of patients working was increasing. Social life remained markedly affected.</p><p><strong>Conclusions: </strong>Two-year outcomes in COVID-19 ECMO patients were stable to improving as compared to 6-month results. However, long-term impairments affected all aspects of life. Long COVID specifically, and post ECMO sequelae in general need to be characterized further to enable maximum recovery.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"146-154"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are there any session-to-session changes in ventilation during a weekly hemodialysis cycle?","authors":"Mauro Pietribiasi, John K Leypoldt, Monika Wieliczko, Malgorzata Debowska, Jolanta Malyszko, Jacek Waniewski","doi":"10.1177/03913988251314664","DOIUrl":"10.1177/03913988251314664","url":null,"abstract":"<p><p>Significant changes in pre-dialytic partial pressure of CO₂ (pCO₂) during a week-long cycle of hemodialysis (HD) can be an effect of the intermittent supplementation of bicarbonate to correct chronic acidosis in patients. Mathematical modeling efforts carried out using the same parameters before each HD session might fail to produce accurate predictions of pCO₂ and plasma bicarbonate concentration (C_Bic) because of this variability. A numerical model describing acid-base equilibrium changes during HD was applied to predict pCO₂, pH, and C_Bic in 24 chronic HD patients, using both fixed parameters for the whole week and estimating a new value of minute ventilation (V_E) and net acid generation rate (G_H) for each interdialytic interval. Dialysances of bicarbonate and dissolved CO₂ were also estimated independently for each HD session. The error of the model compared to the pre-dialytic data of C_Bic and pCO₂ significantly decreased when V_E and G_H were estimated piecewise throughout the week. To fit the data, V_E changed from 3.9 ± 1.0 mL/min before HD1, to 3.8e1 mL/min after HD1, 3.6 ± 1.0 mL/min after HD2, and 3.9 ± 1.1 mL/min after HD3 (<i>p</i> < 0.05). G_H changes after each session were not statistically significant. V_E values strongly correlated with pre-dialytic pCO₂ (Spearman's ρ = -0.97), but G_H only weakly correlated with pre-dialytic C_Bic (ρ = -0.30). Acid-base equilibrium is extremely sensitive to respiratory regulation. When attempting to predict the evolution of pCO₂ a C_Bic during the HD cycle, changes in the respiration parameters must be accounted for by the model, at the risk of a significant loss of prediction accuracy.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"180-187"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}