International Journal of Artificial Organs最新文献

The effect of left ventricular assist devices on the propagation of coronary artery disease in explanted hearts. 左心室辅助装置对移植心脏冠状动脉疾病传播的影响。

IF 1.3 4区医学

International Journal of Artificial Organs Pub Date : 2025-10-18 DOI: 10.1177/03913988251385486

Thomas Auen, Laura Lienemann, Adam Burdorf, Scott W Lundgren, Stanley Radio

{"title":"The effect of left ventricular assist devices on the propagation of coronary artery disease in explanted hearts.","authors":"Thomas Auen, Laura Lienemann, Adam Burdorf, Scott W Lundgren, Stanley Radio","doi":"10.1177/03913988251385486","DOIUrl":"https://doi.org/10.1177/03913988251385486","url":null,"abstract":"As a surgical treatment option for heart failure, left ventricular assist devices (LVAD) help to restore function in failing hearts. Recent studies suggest possible negative impacts of this therapy, as LVAD reduces blood flow and allows potential for coronary remodeling and increased intimal alteration. Our study examined patients with clinically diagnosed non-ischemic cardiomyopathy (NICM) and subsequent heart failure necessitating transplantation and the use of LVAD as a bridge to transplant. Surgically explanted heart specimens were identified and both semi-quantitatively scored and quantitatively assessed for the degree of cross-sectional coronary artery luminal narrowing. Non-parametric statistical analysis of semi-quantitative scored cases was conducted to examine differences between the test population and a control population of NICM patients undergoing transplant without the use of LVAD bridge to therapy. Parametric analysis of the quantitative digitally assessed cases was conducted to corroborate these results. The test population demonstrated a statistically significant difference in coronary artery luminal narrowing compared to the control population. Our findings suggest increased coronary artery disease in previous NICM patients receiving LVAD as a bridge to transplantation regardless of the time with the implanted device. Further work is necessary for future correlation, as these findings bear importance for improving transplant patient outcomes.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988251385486"},"PeriodicalIF":1.3,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145312853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to Abdullah Saad's critical appraisal. 对阿卜杜拉·萨阿德批评性评价的回应。

IF 1.3 4区医学

International Journal of Artificial Organs Pub Date : 2025-10-03 DOI: 10.1177/03913988251360556

Zina Zhu, Yupeng Zhang

引用次数: 0

Design and optimization of antithrombogenic surface textures on bileaflet mechanical heart valves. 双肢机械心脏瓣膜抗血栓表面结构的设计与优化。

IF 1.3 4区医学

International Journal of Artificial Organs Pub Date : 2025-09-29 DOI: 10.1177/03913988251377634

Kuilin Meng, Yumiao Wang, Jianye Zhou, Qiwei Liu, Haosheng Chen, Yongjian Li

{"title":"Design and optimization of antithrombogenic surface textures on bileaflet mechanical heart valves.","authors":"Kuilin Meng, Yumiao Wang, Jianye Zhou, Qiwei Liu, Haosheng Chen, Yongjian Li","doi":"10.1177/03913988251377634","DOIUrl":"https://doi.org/10.1177/03913988251377634","url":null,"abstract":"Background: High shear rate and non-physiological turbulent flow caused by bileaflet mechanical heart valves (BMHVs) lead to platelet activation and adhesion, which can cause rapid thrombus growth and severe consequences.Methods: This study employed computational modeling to analyze the effect of surface texture on flow field around the BMHVs. The textures' positional, geometric, and dimensional parameters were optimized based on flow field analysis. The textured BMHVs were then implanted in sheep for 6 months, with pyrolytic carbon BMHVs serving as the control group.Results: The textured BMHVs significantly reduced high-velocity, low-velocity, high turbulent shear stress, and high shear rate regions in the flow field. Post-implantation, the experimental groups with textured BMHVs exhibited lower levels of platelet activation and neither the intrinsic nor extrinsic coagulation cascade reactions were activated in the sheep. Detailed observations revealed an absence of erythrocyte or platelet adhesion within the grooved texture regions, with minimal adhesion at the peripheral edges of the textured areas.Conclusion: The optimized surface textures on BMHVs effectively reduce adverse flow conditions and platelet activation, potentially decreasing the need for anticoagulant therapy and minimizing the associated bleeding risks. These findings are crucial for enhancing the long-term safety and efficacy of BMHV implantation.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988251377634"},"PeriodicalIF":1.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Empowering healthcare: Secure hand gesture authentication in medical IoT with sEMG. 赋能医疗保健：利用肌电图在医疗物联网中保护手势身份验证。

IF 1.3 4区医学

International Journal of Artificial Organs Pub Date : 2025-09-01 Epub Date: 2025-09-15 DOI: 10.1177/03913988251370224

P Venkateswari, R Nagendran, M Rohini, S Oswalt Manoj

{"title":"Empowering healthcare: Secure hand gesture authentication in medical IoT with sEMG.","authors":"P Venkateswari, R Nagendran, M Rohini, S Oswalt Manoj","doi":"10.1177/03913988251370224","DOIUrl":"10.1177/03913988251370224","url":null,"abstract":"Enhancing information security via reliable user authentication in wireless body area network (WBAN)-based Internet of Things (IoT) applications has garnered increasing attention. Traditional biometric methods, like fingerprint recognition, carry significant privacy risks because they cannot be cancelled or changed. Once a biometric template is exposed, it cannot be replaced, leading to potential privacy violations. Addressing these challenges, this study proposes a novel Secure EMG Framework, a cancellable biometric modality using surface electromyogram (sEMG) signals encoded by hand gesture passwords for user authentication. sEMG signals are collected from the forearm muscles, specifically the flexor carpi ulnaris (FCU), during hand gestures, forming a unique and secure biometric token. This proposed method enhances security and reliability through a multi-stage process that involves data capture, pre-processing, feature extraction, and machine learning-based computation of matching scores. A cancellable biometric token is generated through the collection of sEMG data during 16 static wrist and hand movements, increasing authentication diversity and security. To ensure signal clarity within the critical frequency range of 5-500 Hz, a Pure Frequency Hamming Filter is used to reduce noise and artifacts in the raw sEMG data. Key time-domain parameters are then extracted to form a 16-length feature vector, enhancing gesture discrimination. To further improve classification accuracy, a Tuned Boost Perfect Classifier is implemented, addressing overfitting and minimizing errors. The matching score computation enables the evaluation of input and registered signal similarity, allowing users to reset compromised biometric tokens. Experimental results validate the method, achieving an accuracy of 99.72%, an F1-score of 96.0%, and an Equal Error Rate (EER) of 0.0037.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"698-714"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anticoagulation in the setting of concomitant temporary mechanical circulatory support: Experience from a quaternary care center in the Middle East and review of the literature. 伴随临时机械循环支持的抗凝治疗：来自中东一家四级护理中心的经验和文献综述。

IF 1.3 4区医学

International Journal of Artificial Organs Pub Date : 2025-09-01 Epub Date: 2025-08-03 DOI: 10.1177/03913988251359952

Omar El Khatib, Mohamed Hisham, Salma Al Shaqfa, Hussam H Ghalib, Shreya Pai, Iyad Ghazal, Bassam Atallah

{"title":"Anticoagulation in the setting of concomitant temporary mechanical circulatory support: Experience from a quaternary care center in the Middle East and review of the literature.","authors":"Omar El Khatib, Mohamed Hisham, Salma Al Shaqfa, Hussam H Ghalib, Shreya Pai, Iyad Ghazal, Bassam Atallah","doi":"10.1177/03913988251359952","DOIUrl":"10.1177/03913988251359952","url":null,"abstract":"Background: The combination of VA-ECMO and Impella®, known as \"ECpella\" offers an alternative to the method of left ventricle unloading with intra-aortic balloon pump (IABP). Limited information is available to inform anticoagulation management in cases of concomitant use of Mechanical Circulatory Support (MCS) devices.Methods: This retrospective study included 34 patients receiving hemodynamic support through concomitant MCS for cardiogenic shock for a duration exceeding 24 h. Data collection included patients' demographics, comorbidities, transfusion requirements, anticoagulation protocol, time within therapeutic anticoagulation range, and incidence of bleeding or ischemic events.Results: Survival to discharge was 32.4% (11 out of 34). Of the 34 patients, 28 patients were treated with a combination of VA-ECMO and IABP (82.4%), while 6 patients (17.6%) were supported with the ECpella. Patients in the VA-ECMO with IABP group had a longer hospital stay (median = 30 days, IQR = 20-43.5) when compared to the ECpella group (median = 21.5 days, IQR = 6-63). Bleeding was documented in a similar proportion in both arms of the investigation (89% in the VA-ECMO with IABP group and 83% in the ECpella group). Thrombosis was more common in the VA-ECMO with IABP group (17.9%) as compared to the ECpella group (16.7%).Conclusion: Cardiogenic shock requiring concomitant MCS which includes VA-ECMO presents a challenging clinical scenario where the risks of bleeding and thrombosis have to be balanced. Our experience, and review of the literature, highlight the need for further investigation via large retrospective registry analysis as well as randomized controlled trials.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"686-697"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does low pre-dialysis blood volume increase survival? A call for caution. 低透析前血容量能提高生存率吗？提醒大家要谨慎。

IF 1.3 4区医学

International Journal of Artificial Organs Pub Date : 2025-09-01 Epub Date: 2025-06-19 DOI: 10.1177/03913988251351523

Simon Krenn, Daniel Schneditz, David Keane, Sebastian Mussnig, Manfred Hecking

引用次数: 0

Decreasing the hemoadsorption adsorber change interval does not improve time to shock reversal in sepsis: A retrospective study. 缩短血液吸附器更换间隔并不能改善脓毒症休克逆转的时间：一项回顾性研究。

IF 1.3 4区医学

International Journal of Artificial Organs Pub Date : 2025-09-01 Epub Date: 2025-09-16 DOI: 10.1177/03913988251360555

Thomas Köhler, Elke Schwier, Eva Duppre, Janina Hollmann, Carmen Kirchner, Günther Winde, Dietrich Henzler

{"title":"Decreasing the hemoadsorption adsorber change interval does not improve time to shock reversal in sepsis: A retrospective study.","authors":"Thomas Köhler, Elke Schwier, Eva Duppre, Janina Hollmann, Carmen Kirchner, Günther Winde, Dietrich Henzler","doi":"10.1177/03913988251360555","DOIUrl":"10.1177/03913988251360555","url":null,"abstract":"Introduction: One goal of therapeutic efforts in sepsis/septic shock is rapid shock reversal that might be enhanced by adjunctive hemoadsorption by CytoSorb®. We hypothesized that shortening the time the adsorbers are used, reduces the time to shock reversal.Methods: In a retrospective study, we compared two groups of 16 and 17 patients with sepsis/septic shock treated with short change interval (sci) of 14.2 (12.9, 15.2) h/adsorber or long change interval (lci) of 21.7 (17.6, 24.0) h/adsorber.Results: Time to shock reversal, defined as the time from hemoadsorption start to the end of norepinephrine treatment, was similar between groups (sci: 5 (3.8, 12.7), lci: 10.8 (6.5, 18.5) days; p = 0.210) and did not correlate with the change interval. At baseline, the change interval correlated inversely with interleukin-6 (IL-6; p < 0.001). From baseline to day 5 the significant decrease of thrombocytes was more pronounced in the sci group.Discussion: Shortening the CytoSorb® change interval did not promote faster shock reversal, but imbalances in baseline imply patients in the sci group to have been sicker. Hemodynamic instability and high IL-6 levels prompted intensivists to use shorter change intervals. Possibly the increased number of adsorber binding sites was too low to be effective, or the observed spread between the short and lci was ineffective, or shortening of the change interval improved the outcomes of patients with higher risk profiles at baseline. The calculation of an effective hemoadsorption dose, be it by the amount of blood purified, or binding sites, or a combination hereof, remains speculative.Trial registration: Not applicable.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"653-664"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct transauricular ProtekDuo implantation technique by mini thoracotomy. 小开胸直接经耳ProtekDuo植入术。

IF 1.3 4区医学

International Journal of Artificial Organs Pub Date : 2025-09-01 Epub Date: 2025-08-16 DOI: 10.1177/03913988251365564

Manuel Pérez-Guillén, Carlos Domínguez-Massa, Tomás Heredia-Cambra, Ana María Bel-Mínguez, Salvador Torregrosa-Puerta, Juan Bautista Martínez-León

引用次数: 0

Determinants of aortic pulse wave velocity adjusted for age in peritoneal dialysis patients. 腹透患者年龄调整主动脉脉波速度的决定因素。

IF 1.3 4区医学

International Journal of Artificial Organs Pub Date : 2025-09-01 Epub Date: 2025-07-09 DOI: 10.1177/03913988251355085

Jamie Beverstock, Andrew Davenport

{"title":"Determinants of aortic pulse wave velocity adjusted for age in peritoneal dialysis patients.","authors":"Jamie Beverstock, Andrew Davenport","doi":"10.1177/03913988251355085","DOIUrl":"10.1177/03913988251355085","url":null,"abstract":"Background: Pulse wave velocity (PWV) is a recognised risk factor for mortality and cardiovascular disease in peritoneal dialysis (PD) patients. However, debate continues as to which factors increase PWV. We reviewed the effect of volume overload and calcium balance on PWV.Methods: Aortic PWV (aoPWV) was measured in PD patients attending for routine assessments of peritoneal membrane function, with assessments of extracellular water with bioimpedance and cardiac biomarkers.Results: A total of 122 patients were included (55.6% male; mean age = 64.8 ± 15.3 years; 36.1% diabetic; median dialysis vintage = 19.5 (7.9-37.3) months; weight = 72.7 ± 16.4 kg; mean aoPWV = 9.9 ± 2.2 m/s). Patients with elevated aoPWV (>2 standard deviations above the age-adjusted mean) were compared to those within the expected range. We found that increased adjusted aoPWV was associated on receiver operator curves (ROC) with younger age (ROC = 0.15, p < 0.001), higher sodium removal (ROC = 0.69, p = 0.002), greater use of hypertonic dialysates (ROC = 0.68, p = 0.04), higher PD ultrafiltration (ROC = 0.68, p = 0.005) and elevated N-terminal probrain natriuretic peptide (NTproBNP; ROC = 0.62, p = 0.38), but with lower residual kidney function (KtVurine; 0.34, p = 0.023). On multivariable analysis, both younger age (OR = 0.90; 95% confidence interval (CI) = 0.86-0.95; p < 0.001) and higher log-transformed NTproBNP (OR = 3.24; 95% CI = 1.05-9.96; p = 0.04) remained independently associated with a raised adjusted aoPWV.Conclusions: This study demonstrates that, after adjusting for age, elevated aoPWV is associated with an increased NTproBNP, suggesting that volume overload increases arterial stiffness. These results reinforce the importance of improving volume control in PD patients to reduce cardiovascular risk.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"665-671"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does absolute blood volume influence long-term survival in chronic hemodialysis patients? 绝对血容量是否影响慢性血液透析患者的长期生存？

IF 1.3 4区医学

International Journal of Artificial Organs Pub Date : 2025-09-01 Epub Date: 2025-06-19 DOI: 10.1177/03913988251351506

Joachim Kron, Stefanie Broszeit, Til Leimbach, Susanne Kron

引用次数: 0