International Journal of Artificial Organs最新文献

Does low pre-dialysis blood volume increase survival? A call for caution. 低透析前血容量能提高生存率吗？提醒大家要谨慎。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2025-06-19 DOI: 10.1177/03913988251351523

Simon Krenn, Daniel Schneditz, David Keane, Sebastian Mussnig, Manfred Hecking

引用次数: 0

Does absolute blood volume influence long-term survival in chronic hemodialysis patients? 绝对血容量是否影响慢性血液透析患者的长期生存？

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2025-06-19 DOI: 10.1177/03913988251351506

Joachim Kron, Stefanie Broszeit, Til Leimbach, Susanne Kron

引用次数: 0

Heart rate control strategies in patients on veno-venous extracorporeal membrane oxygenation support. 静脉-静脉体外膜氧合支持患者的心率控制策略。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2025-06-01 Epub Date: 2025-06-07 DOI: 10.1177/03913988251346714

Donna Barakeh, Kevin R Donahue, Diane Dreucean, Prakruthi Voore, Celia Morton

{"title":"Heart rate control strategies in patients on veno-venous extracorporeal membrane oxygenation support.","authors":"Donna Barakeh, Kevin R Donahue, Diane Dreucean, Prakruthi Voore, Celia Morton","doi":"10.1177/03913988251346714","DOIUrl":"10.1177/03913988251346714","url":null,"abstract":"Background: Despite veno-venous extracorporeal membrane oxygenation (VV-ECMO) support, hypoxemia may persist due to venous shunting past the ECMO circuit into diseased lungs. Heart rate (HR) control therapy in patients with elevated cardiac output (CO) is one strategy to improve the ratio of ECMO flow to CO and reduce shunting.Methods: This retrospective study examined VV-ECMO patients between June 2019 and June 2023 that received ⩾1 HR control agent within 10 days post-cannulation. Efficacy outcomes included trends in hemodynamics, oxygenation, and ventilator and ECMO parameters within 72 h after HR control initiation. Safety outcomes included incidence of hypotension or bradycardia requiring intervention.Results: Thirty-nine patients were included. The most common HR control strategy was initiation of esmolol infusion with transition to an oral beta-blocker after a median overlap of 6 days. Patients experienced reductions in HR and CO; however, there were no substantial changes in oxygenation parameters. Adverse events were minimal, with only two cases of hypotension requiring intervention.Conclusions: While HR control therapy was well tolerated and effectively reduced HR, it did not seem to improve oxygenation. Larger prospective studies should be designed to ascertain the role of HR control strategies in VV-ECMO patients with elevated CO experiencing refractory hypoxemia.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"399-405"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing stress in LVAD recipients: Development of the LVAD Stress Questionnaire. LVAD受者的压力评估：LVAD压力问卷的编制。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2025-06-01 Epub Date: 2025-05-30 DOI: 10.1177/03913988251337881

Connor Tripp, Laura Palmo, Daria Ebneter, Amanda Bowen, Paul B Tessmann, Qingqing Yin, Eileen J Burker

{"title":"Assessing stress in LVAD recipients: Development of the LVAD Stress Questionnaire.","authors":"Connor Tripp, Laura Palmo, Daria Ebneter, Amanda Bowen, Paul B Tessmann, Qingqing Yin, Eileen J Burker","doi":"10.1177/03913988251337881","DOIUrl":"10.1177/03913988251337881","url":null,"abstract":"Background: Patients receiving left ventricular assist device (LVAD) implantation can experience significant psychological stress that negatively impacts quality of life and treatment outcomes. Assessment of LVAD stress is critical for providing targeted interventions and advancing the relevant literature. The goal of this study was to establish a new measure of LVAD-specific patient stress, the LVAD Stress Questionnaire (LSQ).Methods: The LSQ is an 18-item measure developed by researchers with extensive clinical experience providing psychological assessment and care for LVAD candidates and recipients. In this study, the LSQ was evaluated with a sample of 73 participants post-LVAD implant.Results: Results of factor analysis supported the use of an LSQ full-scale score, also yielding five subscales of distinct areas of stress. Cronbach's alpha indicated that the full scale and subscales had reasonable to good internal consistency. The LSQ full scale score and four of the subscale scores were positively associated with depression and anxiety. Younger age, female gender, and being unpartnered were associated with higher LVAD stress based on one or more subscale scores.Conclusions: The LSQ is a useful tool that treatment teams can utilize to ascertain whether and in which area an LVAD causes stress, thereby informing interventions to maximize patient outcomes.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"393-398"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual concomitant CytoSorb hemoadsorption therapy in severe rhabdomyolysis: A novel approach to myoglobin clearance and organ preservation. 双重联合CytoSorb血液吸附治疗严重横纹肌溶解：肌红蛋白清除和器官保存的新方法。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2025-06-01 Epub Date: 2025-05-16 DOI: 10.1177/03913988251339080

Marina Pieri, Giada Russo, Claudia Francescon, Evgeny Fominskiy, Pasquale Nardelli, Maria Grazia Calabrò, Annalisa Franco, Sara Fiorito, Silvia Ajello, Anna Mara Scandroglio

{"title":"Dual concomitant CytoSorb hemoadsorption therapy in severe rhabdomyolysis: A novel approach to myoglobin clearance and organ preservation.","authors":"Marina Pieri, Giada Russo, Claudia Francescon, Evgeny Fominskiy, Pasquale Nardelli, Maria Grazia Calabrò, Annalisa Franco, Sara Fiorito, Silvia Ajello, Anna Mara Scandroglio","doi":"10.1177/03913988251339080","DOIUrl":"10.1177/03913988251339080","url":null,"abstract":"Severe rhabdomyolysis, characterized by extensive muscle breakdown and release of myoglobin and creatine kinase (CK), is a life-threatening condition often complicated by acute kidney injury (AKI) and multi-organ failure (MOF). Even when conventional treatments such as fluid resuscitation and renal replacement therapy (RRT) are timely applied, severe cases remain challenging to manage. Among therapies available in this setting, hemadsorption with CytoSorb has the potential not only to treat rhabdomyolysis through removal of circulating molecules but also to limit or even prevent rhabdomyolysis-related renal failure and MOF. In this case series we present a preliminary experience with a novel use CytoSorb hemoadsorption therapy, which encompassed the use of two CytoSorb cartridges running in parallel, to enhance myoglobin and cytokine clearance. Clinical data from the three patients with severe rhabdomyolysis treated with dual concomitant CytoSorb treatments highlighted marked improvements in CK, renal, hepatic, and inflammatory markers, with possible remarkable impact in containing rhabdomyolysis-related organ failure and death. Further investigation is warranted to establish the opportunity of tailored protocols for critically ill patients.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"429-433"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraventricular flow visualization study in continuous aortic valve closure during axial flow pump support. 轴流泵支持下主动脉瓣连续关闭的心室内血流可视化研究。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2025-06-01 Epub Date: 2025-06-04 DOI: 10.1177/03913988251341759

Guang-Mao Liu, Jian-Qiang Hao, Sheng-Shou Hu

{"title":"Intraventricular flow visualization study in continuous aortic valve closure during axial flow pump support.","authors":"Guang-Mao Liu, Jian-Qiang Hao, Sheng-Shou Hu","doi":"10.1177/03913988251341759","DOIUrl":"10.1177/03913988251341759","url":null,"abstract":"When the cardiac function is minimal, LVAD patients' intraventricular blood flow occurs entirely through the LVAD, the aortic valve is continuously closed, this condition significantly alters intraventricular haemodynamics and increases the risk of intraventricular thrombosis. The aim of this study was to analyse intraventricular blood flow patterns in continuous aortic closure, during axial flow pump support. In vitro flow visualization experiments inside a 3D-printed silicone LV model were conducted to emulate the intraventricular hemodynamic parameters inside the LV during LAP31 axial blood pump support, including the distribution of velocity, vorticity and the standard deviation of velocity. The results showed that the intraventricular blood flows directly from the mitral valve to the blood pump inlet at the three instants of the cardiac cycle when the aortic valve is continuously closed, and the standard deviation of the blood flow velocity in the examined cross-section was uniform. Meanwhile, the strong vorticity was observed in the ventricular wall near the blood pump inlet and below the aorta throughout the cardiac cycle, and the location of the strong vorticity region does not change over time. This phenomenon causes intraventricular blood stagnation in the left ventricular outflow tract and the ventricular wall near the blood pump inlet, which increases the risk of thrombus formation in the heart.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"384-392"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac signal classification leveraging spectral optimization with ChebWave and deep blue particle filtering. 心脏信号分类利用ChebWave和深蓝粒子滤波的频谱优化。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2025-06-01 Epub Date: 2025-05-30 DOI: 10.1177/03913988251341756

Anu Honnashamaiah, Rathnakara Srinivasapandit

{"title":"Cardiac signal classification leveraging spectral optimization with ChebWave and deep blue particle filtering.","authors":"Anu Honnashamaiah, Rathnakara Srinivasapandit","doi":"10.1177/03913988251341756","DOIUrl":"10.1177/03913988251341756","url":null,"abstract":"Electrocardiogram (ECG) signal classification plays a critical role in diagnosing various cardiac conditions by identifying irregularities in heart rhythms. Despite advancements in the field, existing methodologies often rely on basic techniques that inadequately filter noise, leading to degraded performance and misinterpretation of vital features. This study presents the Spectral-Optimized Cardiac Framework (SOCF) approach to enhance the accuracy of ECG classification through advanced noise filtering, comprehensive feature extraction, efficient feature selection and integration of hybrid modelling techniques. The proposed methodology introduces the ChebWave Mean Refinement Filter (CWMRF) for effective noise reduction and to enhance signal clarity while preserving essential characteristics. In feature extraction, the Spectral Essence Extractor (SEE) captures both basic and high order features, providing deeper insights into ECG signals. Additionally, the Deep Blue Particle Optimizer (DBPO) efficiently identify relevant features while mitigating the risk of overfitting. Furthermore, the hybrid architecture of Convolutional neural network (CNN) and long short-term memory (LSTM) enable the model to effectively capture both spatial and temporal dependencies, thereby improving classification accuracy. To optimize performance, the Aquila Optimizer enhances the convergence speed and model efficiency by employing diverse search strategies inspired by the hunting behavior of Aquila bird. By integrating these advanced techniques, the SOCF achieved impressive results on the MIT-BIH dataset and PTB dataset with an accuracy of 99.6% and 99.68%, precision of 99.4% and 99.44%, recall of 99.5% and 99.51%, and F1 score of 99.2% and 99.49%, which significantly improves the robustness and reliability of ECG signal classification, ultimately providing more accurate clinical insights and better patient outcomes.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"406-428"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimization of hemocompatibility metrics in ventricular assist device design using machine learning and CFD-based response surface analysis. 利用机器学习和基于cfd的响应面分析优化心室辅助装置设计中的血液相容性指标。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2025-06-01 Epub Date: 2025-06-06 DOI: 10.1177/03913988251346712

Mohamed Bounouib, Mourad Taha-Janan, Wajih Maazouzi

{"title":"Optimization of hemocompatibility metrics in ventricular assist device design using machine learning and CFD-based response surface analysis.","authors":"Mohamed Bounouib, Mourad Taha-Janan, Wajih Maazouzi","doi":"10.1177/03913988251346712","DOIUrl":"10.1177/03913988251346712","url":null,"abstract":"Ventricular assist devices (VADs) are essential for end-stage heart failure patients, but their design must balance hydraulic efficiency and hemocompatibility to minimize blood damage. This study presents a multi-objective optimization framework integrating computational fluid dynamics (CFD), Random Forest Regression (RFR), and Bayesian optimization to improve VAD rotor hemocompatibility. Seven key design parameters (inlet/outlet blade angles, blade count, rotational speed, clearance gap, blade thickness, and rotor length) were optimized using a D-optimal design of experiments. The RFR surrogate model demonstrated superior performance in handling the complex parameter interactions, achieving high predictive accuracy (R2 > 0.84 for all hemocompatibility metrics). CFD simulations employing a Carreau-Yasuda blood model and rigorous mesh independence analysis evaluated shear stress distributions, exposure times, hemolysis index (HI), and platelet activation state (PAS). The optimized design achieved 97.24% of blood flow with shear stress <50 Pa, a HI of 0.01%, and PAS of 1 × 10-6%, representing significant improvements over baseline configurations. While this computational study provides comprehensive parametric insights, future experimental validation is recommended to confirm these findings under physiological conditions. The proposed framework offers a systematic approach for developing high-performance VADs with enhanced hemocompatibility.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"367-383"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic simulation of a left ventricular assist device under coupled working state with the natural heart. 左心室辅助装置与自然心脏耦合工作状态下的动态仿真。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2025-05-01 Epub Date: 2025-05-30 DOI: 10.1177/03913988251335148

Shulei Li, Xingmin Gui, Donghai Jin, Chengxuan Su, Guangmao Liu, Xihang Jiang

{"title":"Dynamic simulation of a left ventricular assist device under coupled working state with the natural heart.","authors":"Shulei Li, Xingmin Gui, Donghai Jin, Chengxuan Su, Guangmao Liu, Xihang Jiang","doi":"10.1177/03913988251335148","DOIUrl":"10.1177/03913988251335148","url":null,"abstract":"Background: The left ventricular assist device (LVAD) goes through a counterclockwise dynamic characteristic loop under heart-pump coupled working state. However, few studies have investigated the underlying physical mechanisms from the flow field perspective.Method: Computational fluid dynamic (CFD) methods are used for unsteady flow field simulations and hemolytic possibility predictions in one cardiac cycle. The pressure boundary conditions are set based on the prior in vitro experiment.Results: Flow blockage started at the inlet guide vanes (IGVs) and affected the downstream flow field at early systole, and occurred mainly at the outlet guide vanes (OGVs) during diastole. At a typical flow-rate, the residence time in IGVs accounted for 42.55% of all parts during systole whereas only 18.75% during diastole.Conclusion: The dynamic characteristic loop is closely related to the movement of vortices within the pump, as the low-speed vortices failing to respond in time to the changes in boundary conditions. An increased likelihood of adverse events is anticipated at early systole.Significance: This study reveals the physical mechanisms underlying the flow field changes within the pump during coupled working. The detailed hemolytic analysis at different cardiac events helps the subsequent real-time intelligent pump adjust strategies.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"332-347"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing the precision of in vitro hemolysis testing for blood pumps: A review. 提高血泵体外溶血检测精度的研究进展。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2025-05-01 Epub Date: 2025-05-16 DOI: 10.1177/03913988251338141

Xu Mei, Liudi Zhang

{"title":"Enhancing the precision of in vitro hemolysis testing for blood pumps: A review.","authors":"Xu Mei, Liudi Zhang","doi":"10.1177/03913988251338141","DOIUrl":"10.1177/03913988251338141","url":null,"abstract":"In vitro hemolysis, assessed through the normalized hemolysis index (NIH) and the modified hemolysis index (MIH), serves as a critical indicator of the hemocompatibility of rotary blood pump designs. Despite the widespread application of the American Society for Testing and Materials (ASTM) standards in conducting in vitro hemolysis testing, the NIH and MIH values for a specific pump can vary considerably across different research centers or even between individual tests. To reduce this variability and facilitate global comparisons of hemolysis levels, this article reviews the underlying theory, existing literature, and empirical knowledge, alongside the practices implemented at the authors' facility. The reviewed factors influencing the variability of the hemolysis index encompass the selection of blood donor species, the source and method of blood withdrawal, blood handling and regulation, the choice of anticoagulants, the configuration of the circulation loop, local flow conditions within the loop, and the measurement of plasma-free hemoglobin. Detailed justifications and recommendations for each factor within a standardized testing framework are provided. The three primary factors that may yield more reliable and universally comparable results include enhancing clinical relevance, minimizing additional blood damage, and preventing blood clot formation. By regulating the associated parameters, it is possible to minimize measurement variance even in the absence of a predictive device.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"283-292"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0