International Journal of Artificial Organs最新文献_第2页

The pattern of cytokine profile in children received extracorporeal blood purification.

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2025-01-24 DOI: 10.1177/03913988251313885

Wun Fung Hui, Renee Wan Yi Chan, Chun Kwok Wong, Wing Lum Cheung, Shu Wing Ku, Kam Lun Hon

{"title":"The pattern of cytokine profile in children received extracorporeal blood purification.","authors":"Wun Fung Hui, Renee Wan Yi Chan, Chun Kwok Wong, Wing Lum Cheung, Shu Wing Ku, Kam Lun Hon","doi":"10.1177/03913988251313885","DOIUrl":"https://doi.org/10.1177/03913988251313885","url":null,"abstract":"We reported the cytokine profile in children <18 years old who received extracorporeal blood purification (EBP) for sepsis, rhabdomyolysis, hyperbilirubinaemia, acute respiratory distress syndrome or cytokine storm, and determined the factors affecting the cytokine removal kinetics. Plasma levels of 38 types of cytokine/chemokine were measured at pre-EBP, 12 and 24 h after initiating EBP. Altogether there were 11 eligible episodes admitted between April 2021 and December 2023. 72.7% were male with a median (25th, 75th percentile) age of 8.7 (5.4, 15.7) years old. The overall mortality rate was 45.5% but there was no EBP-associated mortality. EBP modalities included Cytosorb® haemoadsorption (63.6%) and Oxiris® haemodiafiltration (36.4%). Thirty-seven (97.4%) cytokines exhibited a concentration reduction following EBP, and 60.5% achieved a ≥50% concentration reduction. The median removal ratio was 35.0 (21.0, 53.7)% at 12 h and 55.0 (42.1, 83.1)% at 24 h. Survivors showed a significantly higher number of cytokines with ⩾50% removal ratio at 24 h (28 vs 7, p = 0.017) and better removal ratio of anti-inflammatory cytokines at 12 h (67.9% vs 0%, p = 0.030). A higher pre-EBP cytokine concentration and higher blood flow rate were significantly associated with better removal in 16 (42.1%) and 32 (84.2%) cytokines respectively. Our study demonstrated that both devices can safely and effectively reduce the cytokine and chemokine levels in critically ill children with various conditions.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988251313885"},"PeriodicalIF":1.4,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on the effectiveness and safety of artificial intermittent infusion hemodiafiltration in MHD patients with intradialytic hypotension. 人工间歇输注血液滤过治疗MHD伴溶性低血压的有效性和安全性研究。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2025-01-08 DOI: 10.1177/03913988241310985

YanNa Fan, Fen Wang, Menglin Zou, Laimin Luo, Ying Wang

{"title":"Study on the effectiveness and safety of artificial intermittent infusion hemodiafiltration in MHD patients with intradialytic hypotension.","authors":"YanNa Fan, Fen Wang, Menglin Zou, Laimin Luo, Ying Wang","doi":"10.1177/03913988241310985","DOIUrl":"https://doi.org/10.1177/03913988241310985","url":null,"abstract":"Objective: To evaluate the effectiveness and safety of artificial intermittent infusion hemodiafiltration (I-HDF) in maintenance hemodialysis (MHD) patients with intradialytic hypotension (IDH), and to determine the optimal infusion dosage.Methods: This single-center, prospective, self-controlled study included 30 MHD patients with IDH, treated from December 2022 to July 2023. Patients underwent three sessions of I-HDF as treatment group and conventional hemodialysis as control group. Comparisons were made between the two groups regarding changes in blood pressure, hypotension symptoms, changes in body water content, and achievement of infusion doses.Results: 1. The fluctuation amplitude of SBP in the treatment group was 18.96 ± 10.400, while in the control group it was 27.4 ± 11.796. There was a significant difference between the two groups (p < 0.05). 2. During 90 sessions of dialysis, 39 interventions were needed in the treatment group, compared to 59 interventions in the control group. The treatment group required fewer interventions, with a significant difference (p < 0.05). 3. No hypotension symptoms occurred in the treatment group, whereas six cases were observed in the control group, which was significantly higher (p < 0.05). 4. One patient in the 250 ml infusion group experienced chest tightness. Among the three infusion groups, the 250 ml group had the greatest fluctuation in DBP, with a significant difference (p < 0.05). 5. Among the three infusion volumes groups, there was a significant difference between the theoretical and actual infusion volumes in the 150 and 200 ml groups (p < 0.05).Conclusion: The artificial I-HDF mode effectively improves the occurrence of IDH. An infusion dose of 150-200 ml is deemed appropriate.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988241310985"},"PeriodicalIF":1.4,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of early rehabilitation on therapeutic outcomes in ICU patients on mechanical ventilation: A meta-analysis. 早期康复对ICU机械通气患者治疗结果的影响：一项meta分析。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2025-01-08 DOI: 10.1177/03913988241311816

Saisai Li, Xiulu Xu, Jingjing Hu, Yuexia Wang

{"title":"The effect of early rehabilitation on therapeutic outcomes in ICU patients on mechanical ventilation: A meta-analysis.","authors":"Saisai Li, Xiulu Xu, Jingjing Hu, Yuexia Wang","doi":"10.1177/03913988241311816","DOIUrl":"https://doi.org/10.1177/03913988241311816","url":null,"abstract":"Objective: To evaluate the effect of early rehabilitation on therapeutic outcomes of patients in the ICU requiring mechanical ventilation.Methods: Electronic databases up to June 15, 2024 were searched. Randomized controlled trials (RCTs) that compared early rehabilitation with standard rehabilitation for patients in the ICU on mechanical ventilation were included. The effects of early rehabilitation on outcomes such as duration of mechanical ventilation (days), ICU length of stay (days), hospital length of stay (days), ICU and in-hospital mortality, and ICU-acquired weakness (ICU-AW) were evaluated using a random-effects model.Results: Nineteen RCTs met the inclusion criteria for this study, involving 3076 patients in the ICU on mechanical ventilation. Meta-analysis based on the random-effects model showed that early rehabilitation significantly reduced the duration of mechanical ventilation, ICU-AW risk, ICU length of stay, and total hospital length of stay. Analysis of the timing of early rehabilitation indicated that implementing early rehabilitation within ⩽48 or ⩽72 h after ICU admission or mechanical ventilation had varying effects on the duration of mechanical ventilation, ICU length of stay, and total hospital length of stay.Conclusion: Early rehabilitation can improve the therapeutic outcomes for ICU patients on mechanical ventilation. The optimal time for implementing early rehabilitation appears to be 48-72 h after ICU admission or initiation of mechanical ventilation, but further research is needed.Clinical trial number: INPLASY202470068.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988241311816"},"PeriodicalIF":1.4,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is preloading with amikacin a measure able to mitigate sequestration? A preliminary in vitro study. 预加载阿米卡星是一种能够减轻封存的措施吗？初步体外研究。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2025-01-06 DOI: 10.1177/03913988241310043

Pascal Houzé, Jean-Herlé Raphalen, Valentin Maulet, Lionel Lamhaut, Frédéric J Baud

{"title":"Is preloading with amikacin a measure able to mitigate sequestration? A preliminary in vitro study.","authors":"Pascal Houzé, Jean-Herlé Raphalen, Valentin Maulet, Lionel Lamhaut, Frédéric J Baud","doi":"10.1177/03913988241310043","DOIUrl":"https://doi.org/10.1177/03913988241310043","url":null,"abstract":"Introduction: Amikacin is sequestered in polyacrylonitrile filters. Methods mitigating sequestration are unknown. Amikacin elimination in a polyacrylonitrile-derived filter preloaded with amikacin was studied in a preliminary study.Methods: Amikacin concentrations were determined using an immunochemical method. Prismaflex™, Baxter-Gambro, and the ST™150 filter were used. Sessions were performed in a continuous diafiltration mode. Diafiltration flow rate was set to 2500 mL/h and filtration to 500 mL/h pre- and 1000 mL/h post-dilution. Net loss was set to zero. In sessions with preload, a 150 mg dose of amikacin was injected in the first 1 L bag of physiological saline when starting the priming. NeckEpur® method was used for pharmacokinetic calculations.Results: In the central compartment (CC), the mean initial concentration in the sessions without and with preload was 81.8 ± 6.0 mg/L. There were no significant differences in the AUCcc and AUCinlet without or with preload. The preloading dose induced a significant increase in the AUCoutlet. Compared with sessions without preload, the clearance from the CC in sessions with preload decreased from 4.94 ± 0.43 to 3.75 ± 0.32 L/h, respectively. The elimination rates by diafiltration and sequestration in the sessions without and with preload were 82.3 ± 6.2/17.8 ± 6.2% and 125 ± 9.2%/0 ± 0%, respectively. The 150 mg loading dose was eliminated by diafiltration (42.5%) and by sequestration (57.5%).Conclusion: Preloading filter with amikacin modifies the disposition of amikacin by preventing further sequestration. Studies are needed to define an efficient preloading dosage regimen in actual condition of use.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988241310043"},"PeriodicalIF":1.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the use of standard heparin and 0.9% saline as lock solution in hemodialysis catheter: Importance of closure technique. 标准肝素与0.9%生理盐水作为血液透析导管锁膜液的比较：锁膜技术的重要性。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2025-01-03 DOI: 10.1177/03913988241310759

Fatih Ergül, Mikail Dağ, Beyza Doğan, Edip Erkuş, Ibrahim Guney, Süleyman Karaköse

{"title":"Comparison of the use of standard heparin and 0.9% saline as lock solution in hemodialysis catheter: Importance of closure technique.","authors":"Fatih Ergül, Mikail Dağ, Beyza Doğan, Edip Erkuş, Ibrahim Guney, Süleyman Karaköse","doi":"10.1177/03913988241310759","DOIUrl":"https://doi.org/10.1177/03913988241310759","url":null,"abstract":"Background: Bleeding and thrombotic occlusion are complications of Central venous catheters. When selecting a catheter lock solution, factors such as bleeding, thrombotic occlusion, infection, and cost-effectiveness must be considered.Methods: The study included 35 patients who used heparin as a locking solution and 35 patients who used 0.9% saline, retrospectively. In our center, after injecting the solution equal to the catheter lumen volume from the syringe, approximately 1 cc of locking solution is left in the syringe, the catheter is locked and the syringe is removed from the catheter after locking. Intergroup complications were observed.Results: No significant difference was observed between the groups concerning the catheter insertion site (p = 0.143 and 0.143). Additionally, no significant differences were found between the groups in terms of thrombosis and bleeding complications (p = 0.314 and 0.239, respectively).Conclusion: Our study concluded that heparin locking is not superior to normal saline locking in terms of catheter dysfunction. We aimed to emphasize that the technique of catheter locking is more important than the type of lock solution used.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988241310759"},"PeriodicalIF":1.4,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of power-based control on the haemodynamics and valve function of the biventricular assist circulation system. 动力控制对双心室辅助循环系统血流动力学和瓣膜功能的影响。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2025-01-01 Epub Date: 2025-01-17 DOI: 10.1177/03913988241309186

Fangqun Wang, Chenyang He, Yiliang Ren, Fan Xu, Litao Ding, Mengping Li

{"title":"The effect of power-based control on the haemodynamics and valve function of the biventricular assist circulation system.","authors":"Fangqun Wang, Chenyang He, Yiliang Ren, Fan Xu, Litao Ding, Mengping Li","doi":"10.1177/03913988241309186","DOIUrl":"10.1177/03913988241309186","url":null,"abstract":"Biventricular assist devices (BiVAD) are capable of providing mechanical support to the left and right ventricles to improve blood supply in heart failure, thereby maintaining patients' lives and improving their quality of life. But there is evidence that the incidence of aortic valve incompetence and other valvular pathologies is related to BiVAD support. Such as constant speed (CS) control may cause the valve to close completely and lose its normal valve function. The valve function is related to the percentage of valve opening which is approximately 30% of the cardiac cycle. This study developed a power-based control model for BiVAD that could regulate motors' speed by altering the power to satisfy objectives of keeping valve function and restoring physiologic perfusion. The effects of the power-based controller on the hemodynamics and valve function were investigated by simulating BiVAD under constant power and variable power controls. Different heart failure and activity levels were also mimicked under variable power control to obtain the BiVAD's critical parameters and the assist ratios. The results show that the power-based control can help the BiVAD to assist a patient with heart failure, and the power settings should comprehensively consider objectives of valve function and physiologic perfusion.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3-14"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparing mental health and substance use disorders in patients receiving durable VADs versus transplants: A TriNetX database analysis. 比较接受持久vad与移植患者的精神健康和物质使用障碍：TriNetX数据库分析

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2025-01-01 Epub Date: 2024-12-26 DOI: 10.1177/03913988241305309

Chloe Grzyb, Dongping Du, Balakrishnan Mahesh, Nandini Nair

{"title":"Comparing mental health and substance use disorders in patients receiving durable VADs versus transplants: A TriNetX database analysis.","authors":"Chloe Grzyb, Dongping Du, Balakrishnan Mahesh, Nandini Nair","doi":"10.1177/03913988241305309","DOIUrl":"10.1177/03913988241305309","url":null,"abstract":"Ventricular assist device (VAD) and cardiac transplant patients experience significant strain on their physical and mental wellbeing postoperatively. Mental health and substance use disorders (MHDs and SUDs) have substantial effects on the quality of life and compliance of transplant and VAD patients. In this study, we compare and characterize MHDs and SUDs between VAD and cardiac allograft patients and transplant list patients with and without VADs. This study compares the incidence of MHDs and SUDs between VAD and cardiac transplant patients. Cohorts were defined using ICD-10 codes in TriNetX, a large public database. Patient characteristics were matched by using propensity score matching. Incidence was analyzed using the log-rank test. Statistical significance was set at p < 0.05. Survival analysis showed a statistically significant impact of adjustment disorder, nicotine dependence, and mood disorder in VAD patients as compared to cardiac allograft recipients. Depression and opioid use disorder had a significantly higher incidence in post-transplant patients compared to their VAD counterparts. Survival analysis showed that PTSD and mood disorder had a statistically significant effect on the patients waiting on transplant wait list without VADs as compared to those with VADs. MHDs and SUDs have profound implications on quality of life, survival, and medication compliance. The incidence of MHDs and SUDs differed between VAD versus cardiac transplant patients as well as the patients on the transplant waitlist with and without VADs. Mental health resources should be tailored to address risk factors that may be unique to each group of patients.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"15-22"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Establishment of an inflammation-related acute lung injury/acute respiratory distress syndrome rat model supported by venovenous extracorporeal membrane oxygenation. 静脉-静脉体外膜氧合支持炎症相关性急性肺损伤/急性呼吸窘迫综合征大鼠模型的建立

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2025-01-01 Epub Date: 2024-12-11 DOI: 10.1177/03913988241305085

Wenli Li, Yuansen Chen, Duo Li, Haiwang Wang, Yanqing Liu, Yongnan Li, Haojun Fan

{"title":"Establishment of an inflammation-related acute lung injury/acute respiratory distress syndrome rat model supported by venovenous extracorporeal membrane oxygenation.","authors":"Wenli Li, Yuansen Chen, Duo Li, Haiwang Wang, Yanqing Liu, Yongnan Li, Haojun Fan","doi":"10.1177/03913988241305085","DOIUrl":"10.1177/03913988241305085","url":null,"abstract":"Background: The major concerns for patients who have acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) associated with coronavirus disease 2019 or sepsis and undergone successful venovenous extracorporeal membrane oxygenation (VV ECMO) include a low survival rate and an uncontrollable inflammatory response. This study aimed to introduce an inflammation-related ALI/ARDS rat model supported by VV ECMO that is more suitable for clinical application to assess the immune response and thereby further improve survival after VV ECMO.Methods: Rats were randomly divided into three groups: the sham group, the lipopolysaccharide (LPS) group, and the LPS + ECMO group. ALI/ARDS was induced via intratracheal instillation of LPS in rats. A 5.5 F specially designed bicaval cannulation was placed in the external jugular vein for drainage and reflux. Femoral artery cannulation was used to monitor blood pressure during surgery. Arterial blood gas was measured at baseline and 3 h after VV ECMO support. Finally, lung tissue, bronchoalveolar lavage fluid (BALF) and blood samples were harvested for further evaluation.Results: All LPS-induced ALI/ARDS rats were successfully supported by VV ECMO. The rats survived during the supporting process and maintained effective blood pressure and electrocardiogram (ECG) activity. Compared with the LPS group, VV ECMO support provided oxygen supply to restore lung function and reduced lung injury.Conclusion: We successfully established an inflammation-related ALI/ARDS rat model supported by VV ECMO, in which VV ECMO support alleviated lung injury. Our rat model provides a new tool for immunological research on inflammation-related ALI/ARDS during VV ECMO.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"32-39"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Establishing an interhospital ECMO-transport program during a pandemic: Key lessons learned. 在大流行期间建立医院间ecmo运输规划：吸取的主要经验教训。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2025-01-01 Epub Date: 2024-12-01 DOI: 10.1177/03913988241300860

Mustafa Mert Ozgur, Ece Altınay, Halide Ogus, Hakan Hançer, Hakan Yusuf Koksal, Uzeyir Yılmaz, Tanıl Ozer, Mehmet Aksut, Ozge Altas, İsmail Yerli, Mine Simsek, Atakan Erkilic, Sabit Sarıkaya, Kaan Kırali

{"title":"Establishing an interhospital ECMO-transport program during a pandemic: Key lessons learned.","authors":"Mustafa Mert Ozgur, Ece Altınay, Halide Ogus, Hakan Hançer, Hakan Yusuf Koksal, Uzeyir Yılmaz, Tanıl Ozer, Mehmet Aksut, Ozge Altas, İsmail Yerli, Mine Simsek, Atakan Erkilic, Sabit Sarıkaya, Kaan Kırali","doi":"10.1177/03913988241300860","DOIUrl":"10.1177/03913988241300860","url":null,"abstract":"Background: The emergence of COVID-19 has amplified the importance of efficient patient transfer, leading to the idea of inter-hospital ECMO transport programs. However, there are limited studies on ECMO transfer protocols and experiences during COVID pandemic. This study aimed to evaluate the effectiveness our transport program and provide insights into establishing and maintaining ECMO programs.Methods: Over the period from April 2020 to December 2021, 76 patients with severe hypoxic COVID-19 ARDS were transferred to our center under a veno-venous ECMO support. The transfers were performed by the experienced transport ECMO-team, covering both intracity and intercity transports from various hospitals in Istanbul and the Marmara Region.Results: Mean age was 44 (34-54) years. Time until ECMO initiation was 6 (3-11.2) days. The average transport distance was 36.6 ± 58.7 km. Average intracity and intercity transport distance were 17.5 ± 15.7 and 121 ± 96.6 km, respectively. ECMO wean rate was 40.7% and survival to discharge (home) was 38.1%. No major adverse events occurred during the transfer process. In one transport, the oxygen tank was instantly replenished on the road due to the decrease in the oxygen level in the tank.Conclusion: In conclusion, this study contributed to the knowledge surrounding ECMO transport programs during pandemics, emphasized the importance of expert coordination and careful patient management with demonstrating feasibility of mobile ECMO program .","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"40-47"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing ventricular assist device rotor design parameters through computational fluid dynamics and design of experiments. 通过计算流体动力学和实验设计优化心室辅助装置转子的设计参数。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2025-01-01 Epub Date: 2024-11-25 DOI: 10.1177/03913988241300851

Mohamed Bounouib, Hamza Isksioui, Hind Benakrach, Mourad Taha-Janan, Wajih Maazouzi

{"title":"Optimizing ventricular assist device rotor design parameters through computational fluid dynamics and design of experiments.","authors":"Mohamed Bounouib, Hamza Isksioui, Hind Benakrach, Mourad Taha-Janan, Wajih Maazouzi","doi":"10.1177/03913988241300851","DOIUrl":"10.1177/03913988241300851","url":null,"abstract":"Heart failure is among the most widespread diseases globally. With the rapid rise in the number of affected individuals and the significant disparity between organ demand and supply, the relevance of implantable devices has grown each year. However, these devices face various regulatory restrictions, and obtaining approval requires outstanding performance. This paper focuses on optimizing the design parameters of a rotor for an axial flow ventricular assist device (VAD) currently under development. The parameters investigated include splitters, inlet blade angle, outlet blade angle, blade count, rotational speed, clearance gap, blade thickness, and rotor length. The study aims to maximize pressure rise and hydraulic efficiency while minimizing the torque required to drive the rotor. The D-optimal method was employed to create an experimental design for the simulations. By comparing R², adjusted R², and RMS error across different regression models, the quadratic regression model emerged as the most effective for deriving a suitable mathematical model from the numerical results. The validity of these models was confirmed through the consistency between predicted and observed outcomes.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"23-31"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0