International Journal of Artificial Organs最新文献

{"title":"Comparison of everolimus with calcineurin inhibitors in maintenance immunosuppression.","authors":"Abdulkadir Yılmaz, Doğan Emre Sert, Ümit Kervan, Sinan Sabit Kocabeyoglu, Enis Burak Gül, Murat Gevrek, Şeref Alp Küçüker, Mehmet Ali Özatik, Erol Şener","doi":"10.1177/03913988261429909","DOIUrl":"10.1177/03913988261429909","url":null,"abstract":"<p><strong>Purpose: </strong>The conventional triple immunosuppressive regimen administered following heart transplantation typically comprises a calcineurin inhibitor, an antiproliferative agent, and corticosteroids. Everolimus has emerged as a viable alternative to calcineurin inhibitors. This study aims to evaluate the immunosuppressive efficacy and adverse effect profile of everolimus when introduced after the first post-transplant year, in comparison to continued calcineurin inhibitor therapy.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 90 heart transplant recipients under regular follow up. Patients were categorized into two groups: those who maintained calcineurin inhibitor therapy beyond the first year post-transplant (<i>n</i> = 45), and those who transitioned to everolimus after the first year (<i>n</i> = 45). The groups were compared in terms of rejection incidence and side effects.</p><p><strong>Results: </strong>Following the treatment modification, the everolimus group showed a significant improvement in serum urea and creatinine levels (<i>p</i> < 0.05). Rejection rates after the first year were found to be similar between the two groups.</p><p><strong>Conclusion: </strong>Everolimus provides effective immunosuppression with a lower rate of side effects.It demonstrates a favorable impact on renal function without increasing the risk of rejection.The first year may be recommended as the optimal timing, considering both safe wound healing and the risk of rejection.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"235-240"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147616151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decompensated heart failure in an adolescent with Naxos syndrome managed with central ECMO and HeartMate III LVAD: A case report.","authors":"Mustafa Akdi, Abdulkadir Yılmaz, Sinan Sabit Kocabeyoğlu, Ümit Kervan","doi":"10.1177/03913988261435548","DOIUrl":"10.1177/03913988261435548","url":null,"abstract":"<p><strong>Background: </strong>Advanced heart failure in inherited arrhythmogenic cardiomyopathies poses significant therapeutic challenges, particularly in pediatric patients. Naxos syndrome represents a rare form of such cardiomyopathy, in which mechanical circulatory support may be required.</p><p><strong>Case description: </strong>We present a case of a 14-year-old girl with Naxos syndrome who developed refractory cardiac decompensation complicated by malignant ventricular arrhythmia, necessitating central veno-arterial extracorporeal membrane oxygenation (VA-ECMO) followed by implantation of a HeartMate III left ventricular assist device (LVAD).</p><p><strong>Conclusion: </strong>This report highlights the multidisciplinary management, surgical decision-making, and perioperative challenges encountered during treatment, emphasizing the role of central ECMO as an effective bridge to durable LVAD support and heart transplantation in young patients with complex cardiomyopathies.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"258-263"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Citrate doubles CRRT filter lifespan: A real-world Chinese cohort study.","authors":"Qing Ou, Dan He, Xiuying Shi, Wenjuan Yan, Lengzhen Zhang, Zhili Liang, Li Tang, Yanan Liu, Hongyun Wei","doi":"10.1177/03913988261439936","DOIUrl":"10.1177/03913988261439936","url":null,"abstract":"<p><strong>Background: </strong>Continuous renal replacement therapy (CRRT) plays a crucial role in the management of acute kidney injury (AKI) and fluid overload among critically ill patients. Despite its clinical significance, comprehensive real-world evidence from the Chinese population regarding the clinical application of CRRT, including anticoagulation strategies and factors influencing therapeutic efficacy, remains scarce.</p><p><strong>Methods: </strong>This retrospective cohort study was performed to examine all CRRT treatments administered in the ICU of a tertiary Grade A hospital from July 1 to August 31, 2025. A total of 238 CRRT sessions fulfilling the inclusion criteria were analyzed. Data collected encompassed patient demographics, illness severity scores (APACHE II and SOFA), CRRT treatment parameters, anticoagulation strategies, laboratory indicators, and causes leading to treatment discontinuation. The primary outcome comprised filter survival time, which was analyzed using Kaplan-Meier analysis and Cox proportional hazards models.</p><p><strong>Results: </strong>The analysis included 238 sessions derived from 187 patients (median age 67; 61.3% male). CVVH was the most commonly applied modality (55.9%). Meanwhile, citrate anticoagulation was employed in 49.6% of sessions, followed by heparin (28.2%). The predominant reason for discontinuation was filter clotting (33.6%). Multivariable analysis revealed that the use of citrate anticoagulation was associated with a significantly reduced risk of filter clotting compared to heparin (HR = 0.49, 95% CI 0.29-0.81, <i>p</i> = 0.006). Likewise, a blood flow rate exceeding 150 mL/min was associated with a protective effect (HR = 0.65, 95% CI 0.43-0.98, <i>p</i> = 0.039), whereas mechanical ventilation was associated with an increased risk of filter clotting (HR = 2.15, 95% CI 1.16-3.99, <i>p</i> = 0.015). Finally, median filter survival was 38.5 h for citrate, 18.0 h for heparin, and 26.0 h for nafamostat (log-rank <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>This real-world study demonstrates a strong association between citrate anticoagulation and extended filter lifespan during CRRT, supporting its role as the preferred anticoagulation approach in this setting. Moreover, maintaining adequate blood flow rates and adopting customized anticoagulation management for mechanically ventilated patients may further enhance CRRT efficacy. These findings collectively provide valuable real-world evidence to inform clinical decision-making.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"250-257"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic factors for in-hospital mortality in elderly patients undergoing emergency intubation and invasive mechanical ventilation.","authors":"Xiao Liu, Zhaoxing Tian","doi":"10.1177/03913988261429899","DOIUrl":"10.1177/03913988261429899","url":null,"abstract":"<p><strong>Background: </strong>Elderly patients requiring emergency intubation and invasive mechanical ventilation (IMV) in the emergency department (ED) face substantial mortality risk. However, prediction models utilizing only ED-obtainable variables for early prognostication remain limited.</p><p><strong>Objective: </strong>To develop and internally validate a prognostic model using variables available at ED intubation to predict in-hospital mortality in elderly patients.</p><p><strong>Methods: </strong>This retrospective cohort study included 273 patients aged ⩾ 65 years who underwent emergency intubation and IMV initiation in the ED of a tertiary hospital between June 2019 and June 2024. Candidate predictors included demographics, comorbidities, Glasgow Coma Scale (GCS), vasopressor use, admission lactate, PaO2/FiO2 ratio, shock index, and baseline laboratory values. Multiple imputation addressed missing data. Least absolute shrinkage and selection operator (LASSO) logistic regression identified optimal predictors, followed by multivariate logistic regression. Internal validation employed bootstrap resampling (1000 iterations). Model performance was assessed via discrimination (<i>C</i>-statistic), calibration (calibration plot, Brier score), and clinical utility (decision curve analysis).</p><p><strong>Results: </strong>The overall in-hospital mortality rate was 72.2% (197/273). After LASSO selection and clinical adjudication, the final model included age, GCS score, admission lactate, and vasopressor requirement as independent predictors. The model demonstrated excellent discrimination (<i>C</i>-statistic 0.834, 95% CI: 0.784-0.884), good calibration, and superior net benefit across threshold probabilities of 0.3-0.8 compared to default strategies. Bootstrap-corrected optimism was minimal (optimism-corrected <i>C</i>-statistic 0.827). Sensitivity analyses confirmed model robustness.</p><p><strong>Conclusions: </strong>A parsimonious model incorporating age, GCS score, admission lactate, and vasopressor use accurately predicts in-hospital mortality in elderly patients undergoing emergency intubation and IMV, using only variables readily available at the time of ED presentation. This tool has the potential to facilitate early, evidence-informed shared decision-making.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"267-280"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147591906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical analysis of composite bone plates for tibial oblique fracture repair using finite element analysis.","authors":"Ramananda Sengupta, Raja Dhason, Ali Merdji, Sandipan Roy, Projjal Basu","doi":"10.1177/03913988261439939","DOIUrl":"10.1177/03913988261439939","url":null,"abstract":"<p><p>Tibial fractures are a common type of long bone injuries, requiring solid fixation for quicker bone healing and functional recovery. Metallic plates, although widely use, have been associated to stress shielding due to their enhanced stiffness, which can prevent callus formation and adversely affect the long-term outcomes. This study develops and assesses composite bone plates reinforced with unidirectional carbon fibres in different stacking sequences, comparing their biomechanical performance with titanium plates through finite element (FE) analysis. A 3D model of the tibia with a 1 mm oblique fracture gap was reconstructed from scanned bone data and simulated under physiological axial loading (700 N). Stress distribution within cortical and cancellous bone, plates and screws, as well as axial and shear displacements at the fracture site, were analyzed. Results demonstrated that composite plates (particularly configurations C4, C10 and C11) exhibited higher stress transfer to bone and greater controlled fracture gap movements compared with titanium, thereby minimizing stress shielding and promoting favorable conditions for callus formation. Axial and shear displacements with carbon/epoxy plates were 88% and 48% higher, respectively, than titanium plates, without compromising fixation stability. These findings suggest that carbon fibre-reinforced composites offer a promising alternative to metallic implants by balancing flexibility and stability, though further validation with nonlinear material models, cyclic loading and clinical trials is required.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"281-289"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147689995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-shaped nanoporous poly(methyl methacrylate) fibers for selective adsorption of β₂-microglobulin and other middle-molecular-weight proteins.","authors":"Hiroaki Fujieda, Tomoaki Osuka, Masaru Nakada, Junko Kanda, Tatsuya Kishikawa, Hirokazu Sakaguchi, Masaki Fujita, Masahiro Osabe, Toru Sugata, Hiroyuki Sugaya, Yoshiyuki Ueno","doi":"10.1177/03913988261429904","DOIUrl":"10.1177/03913988261429904","url":null,"abstract":"<p><strong>Background: </strong>Dialysis-related amyloidosis (DRA) is a serious complication in chronic kidney disease patients on long-term dialysis, caused by β₂-microglobulin (β₂-MG) accumulation, and remains challenging owing to the growing dialysis population and extended treatment duration.</p><p><strong>Objectives: </strong>To develop and evaluate stereocomplex poly(methyl methacrylate) (PMMA) adsorbent fibers with optimized cross-sectional and nanoporous structures for efficient, selective β₂-MG removal.</p><p><strong>Methods: </strong>Structured PMMA fibers were fabricated via dry-wet spinning. The adsorption performance of optimized fibers was evaluated with serum containing β₂-MG and other solutes, using scanning electron microscopy (SEM), three-dimensional transmission electron microscopy (3D-TEM), and time-of-flight secondary ion mass spectrometry (TOF-SIMS). Pressure loss simulations compared fiber- and bead-packed columns.</p><p><strong>Results: </strong>Fibers with 12-15 nm pores exhibited maximal β₂-MG adsorption. Cross-shaped fibers exhibited the highest blood-contact surface area and adsorption capacity. A thin surface-dense layer (<0.1 μm) improved β₂-MG diffusion while limiting albumin uptake. TOF-SIMS confirmed uniform β₂-MG penetration, with albumin confined near the fiber surface. Adsorption exceeded 50% for mid-weight proteins (~52 kDa), including IL-6, α₁-microglobulin (α₁-MG), and TNF-α. Pressure loss simulations showed that fiber-packed columns had lower resistance than bead-packed columns.</p><p><strong>Conclusions: </strong>Optimized cross-shaped PMMA fibers enable efficient, selective β₂-MG removal and favorable flow dynamics for hemoperfusion therapies targeting mid-weight uremic toxins.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"167-175"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there a difference in dialysis sessional calcium balance between haemodiafiltration and highflux haemodialysis sessions.","authors":"Roohi Chhabra, Haalah Shaaker, Priyanka Khatri, Andrew Davenport","doi":"10.1177/03913988261429917","DOIUrl":"10.1177/03913988261429917","url":null,"abstract":"<p><strong>Background: </strong>The number of kidney dialysis patients treated by haemodiafiltration continues to increase. Previous studies have suggested that more calcium is removed during haemodiafiltration (HDF) sessions than haemodialysis (HD), particularly with pre-dilution haemodiafiltration (pre-HDF). So, we investigated whether there were differences between post-haemodiafiltration (post-HDF), pre-HDF and high flux HD treatments.</p><p><strong>Methods: </strong>We collected a continuous aliquot of effluent dialysate during dialysis sessions, and calculated dialysis calcium mass balance by the difference between the amount of calcium delivered in fresh dialysate and that lost in effluent dialysate.</p><p><strong>Results: </strong>Effluent dialysate was collected during 244 dialysis sessions (post-HDF (70.9%), HD (20.1%), pre-HDF (9.0%)) from 154 patients, 99 male (64.3%) median dialysis vintage of 21.4 (11.0-55.3) months. Although the total amount of calcium delivered was significantly greater with pre-HDF (168.9 (150.1-203.9) versus post-HDF (141.9 (127.2-165.1) versus HD (125.7 (119.4-127.2) mmol), as was calcium in the effluent dialysate, so the over-all sessional calcium balances were similar (pre-HDF 5.5 (-4.3 to 14), post-HDF (5.6 (-1.1 to 11.9) and HD 6.1 (-3.5 to 11.2) mmol. Calcium balance was predominantly dependent on dialysate calcium concentration (rho 0.59, <i>p</i> < 0.001), and in a multivariable model higher dialysate calcium concentration (odds ratio: 35,509, 95% CI: 280-4.5 × 10⁶, <i>p</i> < 0.001), whereas ultrafiltration lowered calcium balance (odds ratio: 0.35, 95% CI: 0.18-0.67, <i>p</i> = 0.002).</p><p><strong>Conclusion: </strong>We found no difference in dialysis sessional calcium balance between the different modes. When switching patients from HD to HDF, the choice of dialysate calcium should be individualised according to bone-mineral health rather than the dialysis modality.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"176-183"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemodynamic effects of IABP placement on heart and visceral organs due to postcardiotomy shock.","authors":"Huseyin Durmaz, Mustafa Dagli, Mustafa Cunety Cicek, Semiha Durmaz, Abdullah Degirmen, Kadir Durgut","doi":"10.1177/03913988261432159","DOIUrl":"10.1177/03913988261432159","url":null,"abstract":"<p><strong>Introduction: </strong>Postcardiotomy shock is a condition characterized by a very high mortality rate in patients with low output following cardiac surgery. Providing mechanical circulatory support using an intra-aortic balloon pump (IABP) is one treatment option for this condition. IABP is known to have a positive hemodynamic effect on some organs. However, significant hemodynamic studies on end-organs are not yet available in the literature.</p><p><strong>Methods: </strong>This retrospective study included 75 patients who underwent coronary artery bypass grafting (IABP) at the Cardiovascular Surgery Clinic of Konya City Hospital between December 2020 and July 2025 and underwent postcardiotomy shock. Patients were divided into two groups based on IABP location. Laboratory findings were used to analyze the hemodynamic effects of IABP location on end organs and the heart.</p><p><strong>Results: </strong>No statistically significant differences were observed between the IABP placement site and age, BMI, duration of IABP use, or any preoperative and postoperative laboratory parameters. While the preoperative AST/ALT ratio did not differ significantly between the two groups, the postoperative AST/ALT ratio was found to be significantly higher in the supradiaphragmatic IABP placement group compared with the infradiaphragmatic IABP placement group.</p><p><strong>Conclusion: </strong>The IABP is one of the mechanical support devices used to manage postcardiotomy shock after coronary bypass surgery. Although it is used for its beneficial effects on cardiac hemodynamics, it can also cause changes in visceral organs in some cases.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"199-205"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formatted water-soluble ribbon for roll porous scaffold 3D bioprinting.","authors":"Vyacheslav R Shulunov, Sergey A Stelmakh, Mariya N Grigor'eva","doi":"10.1177/03913988261422332","DOIUrl":"10.1177/03913988261422332","url":null,"abstract":"<p><p>Progress of breakthrough Roll Porous Scaffold (RPS) 3D Bioprinting technology with great potential for personalized medicine, targeted therapy and overcoming the shortage of organs for implantation achieves first physical confirmation. The efficiency of RPS for the formation of solid organoid can exceed liters per hour with ~10-35 µm cells in 5, 18, and 84 pL drops due to significantly increased print exposure for cell filtration and based on the lines of many usual Kyocera inkjet printheads \"KJ4B-1200,\" \"KJ4C-0360,\" and \"KJ4A-0300, KJ4B-0300\" with resolution of 1200, 360, and 300 DPI accordingly. Films samples were made and a method was developed to control the formation of an object inside a roll not by one, but by two parameters. After laser perforation of these ribbons with 1200 DPI precision, holes size of ~60-120 µm and boundaries of ~20-45 µm respectively, the MTT (methylthiazolyl tetrazolium) assay with 8 replicates for each experimental group according to GOST ISO 10993-5:2023 showed good cell viability of >78%-97%. An additional parameter for formatting the reinforcing tape from a durable incompressible material, which determines the thickness of the wind layer, allows taking into account its uneven height when forming a 3D model of the organoid.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"218-224"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolonged intermittent high-volume hemofiltration in severe septic shock.","authors":"Rodrigo A Sepúlveda, Cristián Juanet, Juan P Huidobro, María E Espinoza, Eduardo Kattan, Eric Roessler","doi":"10.1177/03913988261422328","DOIUrl":"10.1177/03913988261422328","url":null,"abstract":"<p><strong>Background: </strong>Septic shock is a life-threatening condition. Prolonged intermittent high-volume hemofiltration (HVHF) has been used as a hemodynamic support and immunomodulation strategy for patients with severe septic shock.</p><p><strong>Methods: </strong>We studied a retrospective cohort of patients with severe septic shock who received HVHF, evaluating the response to this therapy and the factors associated with mortality.</p><p><strong>Results: </strong>We analyzed 63 patients with severe septic shock (age 62.8 ± 13.8 years, 57.1% female, maximum SOFA 16.1 ± 3.4). Mortality was significantly associated with male sex, medical pathology at admission, chronic critical illness condition, elevated SOFA, and high doses of norepinephrine at the end of HVHF. Patients whose HVHF was performed within 24 h after surgery had lower mortality (<i>p</i> = 0.025). Norepinephrine dose decreased significantly with HVHF (<i>p</i> = 0.038). Mortality in our study was 73%, significantly lower than the predicted mortality by SOFA score: 80%-90% (<i>p</i> = 0.008).</p><p><strong>Conclusion: </strong>HVHF could facilitate the management of critically ill patients with severe septic shock, especially women and surgical patients. It would allow for immunomodulation and hemodynamic support, providing time to control infection and improve the poor prognosis for these patients.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"193-198"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147283642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}