International Journal of Artificial Organs最新文献

{"title":"First successful HeartMate 3 in Vietnam: Anatomical challenges of a small, spherical ventricle, and an oval-shaped thoracic morphology.","authors":"Thai Quang Tran, Anh Tuan Ngo, Hung Quoc Nguyen, Duc Viet Dang, Giang Thai Pham, Song Huu Le, Hai Doan Duy Tran, Jan D Schmitto","doi":"10.1177/03913988261469886","DOIUrl":"10.1177/03913988261469886","url":null,"abstract":"<p><p>Advanced heart failure remains a significant global health burden, with limited access to mechanical circulatory support in developing nations. We report the first successful implantation of a HeartMate 3 (HM3) left ventricular assist device (LVAD) in Vietnam, marking a critical milestone in the country's cardiovascular surgery. The patient, a 46-year-old female with stage D heart failure (NYHA class IIIB, INTERMACS profile 4) secondary to dilated cardiomyopathy, presented with dual anatomical constraints. Preoperative imaging revealed a technically challenging, small, and spherical left ventricle (long-axis: 52 mm). Furthermore, thoracic anthropometry demonstrated a distinct oval-shaped chest morphology common in Asian populations, with a low Thoracic Index of 0.67 (AP diameter 206.1 mm; transverse diameter 305.6 mm), significantly restricting the retrosternal space for device housing. Despite these constraints, the HM3 was successfully implanted through a full sternotomy, with meticulous attention to inflow cannula angulation. At the 6-month follow-up, the patient exhibited dramatic functional recovery (NYHA class I). Her Kansas City Cardiomyopathy Questionnaire (KCCQ-12) score surged from 51.04 to 91.67, and the 6-min walking distance improved from 315 to 450 m, without any device-related adverse events. This case confirms the feasibility of the HM3 in restricted anatomical settings and underscores the importance of considering race-specific thoracic morphology in the planning of advanced mechanical circulatory support.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"828-833"},"PeriodicalIF":1.6,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148630191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In vitro</i> replication of relationship between α₁-microglobulin reduction rate and albumin leakage in post-dilution hemodiafiltration.","authors":"Maozhen Li, Hiroyuki Inoue, Satoru Yamaguchi, Takashi Sunohara, Akihiro C Yamashita","doi":"10.1177/03913988261474708","DOIUrl":"https://doi.org/10.1177/03913988261474708","url":null,"abstract":"<p><p>Efficient removal of middle-to-large molecules, such as α₁-microglobulin (α₁-MG, 33 kDa), is essential for mitigating long-term complications in patients undergoing hemodiafiltration (HDF). However, objective evaluation of diafilter performance requires standardized laboratory systems that can reproduce clinical transport characteristics while monitoring albumin leakage. This study established an <i>in vitro</i> experimental system utilizing recombinant α₁-MG to evaluate post-dilution on-line HDF. Two configurations were compared: Circuit#1, featuring an auxiliary pump at the blood outlet, and Circuit#2, where the pump was removed to optimize flow regulation. Results demonstrated that Circuit#1 significantly deviated from clinical benchmarks due to internal pressure accumulation. Conversely, Circuit#2 successfully mirrored clinical trends, showing a strong positive correlation between α₁-MG removal and albumin leakage. Observed clearances in Circuit#2 were slightly higher than clinical averages, likely due to the smaller molecular weight of the recombinant solute (31 vs. 33 kDa), reduced circulation volume, and the absence of α₁ <i>in vitro</i>-MG-IgA dimer binding complexes. This validated model provides a robust and reliable platform for the standardized assessment and development of next-generation blood purification devices.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988261474708"},"PeriodicalIF":1.6,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-therapeutic niraparib-loaded chitosan nanoparticle-alginate hydrogel with adipose-derived stromal cells promotes functional and histological recovery after spinal cord injury.","authors":"Haibo Pei, Yunfei He, Saman Jalili","doi":"10.1177/03913988261470323","DOIUrl":"https://doi.org/10.1177/03913988261470323","url":null,"abstract":"<p><strong>Background: </strong>Spinal cord injury (SCI) triggers oxidative stress, inflammation, and progressive neurodegeneration.</p><p><strong>Methods: </strong>Here, we developed a dual-therapy composite hydrogel that integrates niraparib-loaded chitosan nanoparticles (NICNPs) and adipose-derived stromal cells (ASCs) into a calcium alginate scaffold for sustained drug release and cell delivery.</p><p><strong>Results: </strong>NICNPs demonstrated comparable encapsulation efficiencies across formulations (44.97% ± 7.23%, 41.54% ± 4.70%, and 44.67% ± 8.81% for 1%, 3%, and 5% loading, respectively), with biphasic sustained drug release over 168 h. All hydrogels supported ASC viability; under oxidative stress, NICNP hydrogels significantly improved cell survival compared with ASC-only hydrogels. In vitro, NICNP-ASC constructs markedly reduced LPS-induced cytokines (TNF-α, IL-6, and IL-1β). In vivo, in a rat SCI model, NICNP-ASC hydrogels significantly reduced lesion volume and enhanced gray and white matter preservation compared to other formulations and the control group. Alginate hydrogel incorporating ASCs and niraparib-loaded chitosan nanoparticles at 5% w/w drug loading (HY-ASC-NICNPs-5) demonstrated maximal efficacy, showing robust parenchymal bridging, dense myelin preservation, and angiogenesis. Behavioral recovery improved significantly, with BBB scores highest in HY-ASC-NICNPs-5 at both 4 and 8 weeks. ELISA confirmed elevated neurotrophic factors and antioxidant enzymes alongside reduced inflammatory cytokines in NICNP-ASC groups, particularly in the 5% formulation.</p><p><strong>Conclusion: </strong>Overall, these dual-functional hydrogel systems created a pro-regenerative microenvironment, attenuated secondary injury cascades, and restored hindlimb motor function.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988261470323"},"PeriodicalIF":1.6,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149136633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of HA60 hemoperfusion on inflammatory markers and organ function in critically ill children with septic shock.","authors":"Serhat Emeksiz, Serhan Ozcan, Furkan Ozturk, Alper Oglakcioglu, Aydın Bozkurt, Sadik Kaya, Esra Kockuzu Direk","doi":"10.1177/03913988261491718","DOIUrl":"https://doi.org/10.1177/03913988261491718","url":null,"abstract":"<p><strong>Objective: </strong>In this study, the efficacy and safety of HA60 hemoadsorption in pediatric sepsis/septic shock and multiple organ dysfunction were evaluated.</p><p><strong>Methods: </strong>Eight patients who underwent HA60 hemoperfusion were analyzed. In addition to standard sepsis treatment, all patients received a single 6-h session with the HA60 filter. Along with the vasoactive inotropic score (VIS), CRP, IL-6, PCT, ferritin, lactate, AST, ALT, LDH, and bilirubin levels were evaluated at 0, 24, 48, and 72 h.</p><p><strong>Results: </strong>The median age was 44.5 months, and 62.5% of the patients were male; 75% had underlying heart disease, all patients received invasive mechanical ventilation and CRRT, and 62.5% required ECMO. Following HA60, a significant decrease in CRP was observed up to 72 h (from 224.7 to 113.4 mg/dL; <i>p</i> < 0.001), together with significant reductions in IL-6, PCT, and ferritin; IL-6 decreased by 71.7%, PCT by 79.7, and ferritin by 70.6% (all <i>p</i> < 0.001). Lactate levels decreased from 3.5 to 2.4 mmol/L (<i>p</i> < 0.001), and significant reductions were detected in AST, ALT, and LDH levels (<i>p</i> < 0.001). A decrease in VIS was observed between the pre-filter and 72 h (from 55 to 45; <i>p</i> = 0.034), and no procedure-related adverse events or hemodynamic instability were observed.</p><p><strong>Conclusion: </strong>In our study, HA60 hemoadsorption was associated with reductions in inflammatory markers, improvements in organ function parameters, and a decrease in vasoactive inotropic scores in critically ill children with septic shock. These findings are preliminary; prospective controlled studies are needed to establish the efficacy and optimal use of HA60 in pediatric septic shock.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988261491718"},"PeriodicalIF":1.6,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Collagen hydrogel incorporated with ginsenoside Rg1-loaded chitosan nanoparticles and adipose-derived stem cells enhances nasal bone fracture healing in rats.","authors":"Xiaoman Wang, Rongrong Diao","doi":"10.1177/03913988261461129","DOIUrl":"10.1177/03913988261461129","url":null,"abstract":"<p><p>Facial bone fractures are extremely common with nasal bone fractures being among the most frequently fractured bones in the body. However, therapeutic approaches for nasal bone fracture treatment have focused primarily on mechanical reduction and stabilization of the fracture site without biologically stimulating tissue repair. The goal of this study was to engineer a nanocomposite collagen hydrogel therapeutic system loaded with ginsenoside Rg1-loaded chitosan nanoparticles (G.Rg1-CNPs) and adipose-derived stem cells (ASCs) to enhance nasal bone fracture healing. To accomplish this objective, G. Rg1-CNPs were synthesized by ionotropic gelation and characterized for encapsulation efficiency, drug loading capacity, release kinetics, and particle morphology. These nanoparticles were combined with collagen hydrogels with and without ASCs to create the hydrogel system. In vitro characterization evaluated included scanning electron microscopy (SEM), cell viability assay, degradation profile, and radical scavenging assay. In vivo evaluations were conducted using rat nasal bone fracture model and included histology, histomorphometry, and ELISA-based biomarker analysis. Following optimization, nanoparticles exhibited moderate encapsulation efficiency and loading capacity with burst release kinetics initially transitioning to sustained release profiles until 72 h. SEM imaging was used to confirm nanoparticle morphology and demonstrated porous interconnected microstructures formed when collagen gels were allowed to polymerize. Metabolic activity assays revealed ASCs incorporated into hydrogels maintained cellular viability and metabolism up to 7 days in vitro. Degradation studies indicated all hydrogel groups experienced steady degradation throughout the 12-day period. Antioxidant capacity studies showed G.Rg1-CNPs had significantly higher activity compared to blank nanoparticles. Animal studies demonstrated hydrogels containing ASCs and G.Rg1-CNPs had the highest overall healing response with improved tissue organization, collagen deposition, new bone formation, decreased expression of pro-inflammatory cytokines, increased anti-inflammatory cytokines, and angiogenic/osteogenic growth factor biomarkers when compared to all other treatment groups. Overall, this nanocomposite hydrogel system enhanced nasal bone fracture healing by creating an optimal regenerative microenvironment.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"735-751"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"The effect of extracorporeal blood purification therapies on mortality in the treatment of septic shock in the intensive care unit\".","authors":"","doi":"10.1177/03913988261468407","DOIUrl":"10.1177/03913988261468407","url":null,"abstract":"","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"752"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148520135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and in vitro evaluation of a parallel gas-exchange chambers oxygenator with reduced hemolysis and pressure drop.","authors":"Yuan Liu, Junwen Yu, Yuanfei Zhu, Huaiyuan Guo, Zhexin Lu, Ming Yang","doi":"10.1177/03913988261462526","DOIUrl":"10.1177/03913988261462526","url":null,"abstract":"<p><strong>Background: </strong>Hemolytic complications remain a major limitation of membrane oxygenators in clinical support. Compared with human lungs, most commercial oxygenators generate substantial pressure drops and high shear stress, increasing the risks of hemolysis. Therefore, we aimed to develop a membrane oxygenator that reduces pressure drop and shear-induced blood damage while maintaining the oxygen transfer rate.</p><p><strong>Methods: </strong>We propose a parallel gas exchange chamber (PGEC) oxygenator in which the blood flow is divided into two identical gas exchange chambers connected in parallel. The computational fluid dynamics (CFD) model was used to design and analyze the oxygenators. The oxygen transfer rate and blood damage parameters of the PGEC and conventional oxygenator were evaluated by in vitro tests at a blood flow rate of 900 mL/min. Oxygen transfer rate, pressure drop, plasma free hemoglobin concentration, and thrombin-antithrombin complex (TAT) concentration were measured (<i>n</i> = 3).</p><p><strong>Results: </strong>Under the present identical in vitro test conditions, the oxygen transfer rate of the PGEC oxygenator (18.15 ± 0.69 mL/min) was not significantly different from that of the conventional oxygenator (17.73 ± 0.73 mL/min). The PGEC design reduced pressure drop by 42% and decreased the normalized index of hemolysis (NIH) by 63% (<i>p</i> = 0.028), while TAT concentrations did not differ significantly between the two circuits.</p><p><strong>Conclusions: </strong>The parallel design of the gas exchange chambers decreases blood velocity in the hollow fiber membrane region, thereby lowering pressure drop and hemolysis while maintaining oxygen transfer rate under the tested conditions.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"715-724"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148535882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic plasma exchange added to CRRT combined with hemoperfusion in wasp sting-associated AKI: A multicenter retrospective cohort study.","authors":"Rong Li, Nan Huang, Dongju Zhang, Chunyan Song, Zhishuang Zhai, Xiaoli Cheng, Jing Wang, Peng Zhang","doi":"10.1177/03913988261456903","DOIUrl":"10.1177/03913988261456903","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate whether adding therapeutic plasma exchange (PE) to continuous renal replacement therapy plus hemoperfusion (CRRT + HP) could improve renal recovery with wasp sting-associated acute kidney injury (AKI).</p><p><strong>Methods: </strong>We conducted a multicenter retrospective cohort study in three tertiary hospitals in the Qinling region of China (July 2015-December 2024). Patients received either CRRT + HP or CRRT + HP + PE within a 72-h exposure window. The primary endpoint was renal recovery, which was analyzed in a competing-risk framework with death as the competing event. Cumulative incidence of renal recovery were compared using Gray's test, and fine-Gray models estimated subdistribution hazard ratios (sHR). Longitudinal changes in key laboratory variables and SOFA scores were assessed with linear mixed-effects models.</p><p><strong>Results: </strong>Among 176 eligible patients (CRRT + HP, <i>n</i> = 103; CRRT + HP + PE, <i>n</i> = 73), baseline severity was higher in the PE group before matching but was well balanced after propensity score matching. In the matched cohort, the CRRT + HP+PE group had a higher 30 days cumulative incidence of renal recovery than CRRT + HP (54.2% vs 32.2%). Overall renal recovery CIF curves favored CRRT + HP+PE (Gray's test, χ² = 6.277, <i>p</i> = 0.0122). In univariable fine-Gray analysis, PE was associated with increased renal recovery (sHR = 1.56, 95% CI 1.07-2.27; <i>p</i> = 0.021), and the association remained significant after multivariable adjustment (sHR 3.97, 95% CI 1.59-10.08; <i>p</i> < 0.001). 90-day mortality was numerically lower with PE but not statistically significant. Serum creatinine, total bilirubin, and SOFA score trajectories were improved faster in the CRRT + HP + PE group.</p><p><strong>Conclusions: </strong>For patients with AKI caused by wasp stings, the addition of PE to CRRT + HP can improve early renal recovery and yield more favorable laboratory trajectories.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"679-688"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148375804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Foot care behaviors and perceived exercise benefits and barriers in diabetic hemodialysis patients.","authors":"Medine Yucesoy Isler, Elif Bulbul","doi":"10.1177/03913988261455770","DOIUrl":"10.1177/03913988261455770","url":null,"abstract":"<p><strong>Purpose: </strong>To examine foot care behaviors, perceived benefits and barriers to exercise, and the relationships between these factors among diabetic patients undergoing hemodialysis.</p><p><strong>Major findings: </strong>This study included 151 adults with type 2 diabetes receiving hemodialysis in Istanbul. Data were collected using the Foot Care Behavior Scale, the Diabetic Foot Care Self-Efficacy Scale, and the Exercise Benefits/Barriers Scale for Dialysis Patients. Descriptive statistics, <i>t</i>-tests, ANOVA, correlation analyses, and linear regression were conducted. Higher education and health literacy were associated with improved foot care behaviors and greater perceived benefits of exercise. Fatigue, comorbidities, and lack of knowledge were identified as major barriers to exercise. Regression analysis showed that gender, age, albumin level, and exercise status significantly influenced perceived benefits and barriers.</p><p><strong>Conclusions: </strong>Nursing interventions should focus on patient education, strengthening self-efficacy, and providing individualized exercise guidance to improve outcomes among diabetic hemodialysis patients. These findings highlight the critical role of nurses in promoting self-care behaviors and physical activity among diabetic hemodialysis patients.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"689-696"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148375835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of clinical characteristics to mortality in acute respiratory failure patients treated with ECCO₂R.","authors":"Ravindranath Tiruvoipati, Alexandra May, Ary Serpa Neto, Bindu Akkanti, Kha Dinh, Nicholas A Barrett, Steven A Conrad","doi":"10.1177/03913988261461123","DOIUrl":"10.1177/03913988261461123","url":null,"abstract":"<p><strong>Background: </strong>Low flow extracorporeal carbon dioxide removal (ECCO₂R) is used to assist in lung protective ventilation. The objective of this study was to compare the characteristics of patients who died in-hospital to those who survived and identify variables pre and during the first 24 h of ECCO₂R support independently associated with hospital mortality.</p><p><strong>Methods: </strong>This study is a multicenter, multinational, retrospective review of data from the Hemolung Registry between April 2013 and June 2021. The primary outcome was hospital mortality.</p><p><strong>Results: </strong>Of the 242 included patients 115 (48%) survived. Prior to ECCO₂R initiation and during the first 24 h of ECCO₂R therapy, patients who died had a lower PaO₂/FiO₂ ratio but higher FiO₂, respiratory rate (RR), and tidal volumes. Age ((OR: 1.51 (95% CI: 1.06-2.14); <i>p</i> = 0.022), RR (1.92 (1.28-2.87); <i>p</i> = 0.002), and FiO₂ (2.33 (1.50-3.62); <i>p</i> < 0.001) were independently associated with increased risk of mortality.</p><p><strong>Conclusions: </strong>Age, respiratory rate, and FiO₂ during the first 24 h of ECCO₂R therapy were independently associated with increased risk of hospital mortality. An ongoing high FiO₂ (>0.7) and respiratory rate ⩾25 during the first 24 h is independently associated with higher risk of hospital mortality.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"725-734"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148411762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}