International Current Pharmaceutical Journal最新文献_第7页

Biological studies concerning the antioxidant and antimicrobial activities of Pelargonium species cultivated in Egypt (Family-Geraniaceae). 埃及天竺葵属植物抗氧化和抗菌活性的生物学研究。

International Current Pharmaceutical Journal Pub Date : 2015-01-07 DOI: 10.3329/ICPJ.V4I2.21481

A. Singab, Hala M. El-Hefnawy, D. G. El-Kolobby

{"title":"Biological studies concerning the antioxidant and antimicrobial activities of Pelargonium species cultivated in Egypt (Family-Geraniaceae).","authors":"A. Singab, Hala M. El-Hefnawy, D. G. El-Kolobby","doi":"10.3329/ICPJ.V4I2.21481","DOIUrl":"https://doi.org/10.3329/ICPJ.V4I2.21481","url":null,"abstract":"Plant-derived pharmaceuticals have become prominent in the market place, making it a favored healthcare choice. In this study, air dried samples of aerial parts of Pelargonium X fragrans Willd. and Pelargonium peltatum L’Herit. were separately extracted using successive extraction with a soxhlet apparatus. Each extract was tested for its antimicrobial activity using two Gram-negative bacterial strains (Pseudomonas aeruginosa and Escherichia coli), two Gram-positive bacterial strains (Bacillus subtillus and Staphyllococcus aureus), and clinical fungal isolates (Aspergillus niger and Candida albicans). Also, their antioxidant activity was tested using a DPPH free radical assay. The ethyl acetate, n-Butanol and the total extracts showed moderate activity against the tested microorganisms with significant high activity against E. coli. The free radical scavenging property was found to be in a concentration dependent manner in all the tested fractions. The most effective antioxidant fractions in both spp. was the n-Butanol fraction (85% and 85.2%) at the concentration of 0.375µg/ml followed by the total ethanolic extracts (78.1% and 84.62%), respectively, with the same concentration compared to the standard reference ascorbic acid which showed a significant radicals scavenging potential (79.1%) in the concentration of 1µg/ml.","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"94 1","pages":"340-342"},"PeriodicalIF":0.0,"publicationDate":"2015-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81244049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antidiabetic and hypolipidemic potential of Rhazya stricta Decne extract and its fractions 榛叶提取物及其组分的降糖尿病和降血脂作用

International Current Pharmaceutical Journal Pub Date : 2015-01-07 DOI: 10.3329/ICPJ.V4I2.21484

Asma Ahmed, M. Asad, M. Ahmad, R. Qureshi, Syed Imam Shah, H. Gul, M. Gulfraz

{"title":"Antidiabetic and hypolipidemic potential of Rhazya stricta Decne extract and its fractions","authors":"Asma Ahmed, M. Asad, M. Ahmad, R. Qureshi, Syed Imam Shah, H. Gul, M. Gulfraz","doi":"10.3329/ICPJ.V4I2.21484","DOIUrl":"https://doi.org/10.3329/ICPJ.V4I2.21484","url":null,"abstract":"Diabetes mellitus is the most common human disease and there is growing interest for plant based therapy in managing diabetes mellitus specifically in the developing world. In the present study, Rhazya stricta Decne extract was analysed for its antidiabetic activities . Crude methanolic extracts of different plant parts were tested in vivo on albino mice Balb-C, for the reduction of blood glucose, urea, cholesterol, triacylglycerides and glycosylated haemoglobin. Results obtained showed that leaves of R. stricta have best antidiabetic effect by reducing blood glucose level, Glycosylated haemoglobin, triacylglycerides and Cholesterol in hyperglycaemic mice. The R. stricta leaves extract being most active was further fractionated by solvent extraction using n- Hexane, ethyl acetate, chloroform and water and all fractions were tested for same activities. It was found that ethyl acetate fraction is most effective in the reduction of blood glucose level at fasting and random conditions and blood glucose reduction was comparable to Glucophage, a standard antidiabetic drug. The present study suggests that Rhazya stricta leaves extract and its ethyl acetate fraction has great potential for development of antidiabetic drug. DOI: http://dx.doi.org/10.3329/icpj.v4i2.21484 International Current Pharmaceutical Journal, January 2015, 4(2): 353-361","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"20 1","pages":"353-361"},"PeriodicalIF":0.0,"publicationDate":"2015-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75854592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Microbiological evaluation of antibacterial potentiality of some edible plant extracts against multidrug resistant (MDR) human pathogens 一些食用植物提取物对多重耐药(MDR)人类病原体抑菌潜力的微生物学评价

International Current Pharmaceutical Journal Pub Date : 2014-12-06 DOI: 10.3329/ICPJ.V4I1.21162

M. El-Sayed, B. Refaat, M. Sharaf

{"title":"Microbiological evaluation of antibacterial potentiality of some edible plant extracts against multidrug resistant (MDR) human pathogens","authors":"M. El-Sayed, B. Refaat, M. Sharaf","doi":"10.3329/ICPJ.V4I1.21162","DOIUrl":"https://doi.org/10.3329/ICPJ.V4I1.21162","url":null,"abstract":"Antimicrobial resistance is a subject of great concern in public health and also in the designing of strategies for current therapeutic protocols all over the world. Plants used for traditional medicine contain a wide range of substances which can be used to treat various infectious diseases. Hence, antibacterial activities of aqueous extracts of 10 plant species were studied against 25 multidrug resistant (MDR) clinical isolates using the agar well diffusion method. The most resistant organisms were Acinetobacter baumanii (A. baumanii) (resistant to 16 different antibiotics), Enterococcus faecium (E. faecium) (resistant to 15 different antibiotics), Pseudomonas aeruginosa (P. aeruginosa) (resistant to 15 antibiotics), Gemella morbillorum (G. morbillorum) (resistant to 14 different antibiotics), Enterobacter cloacae (E. cloacae) (resistant to 13 different antibiotics) respectively. Among the tested plant extracts, only extracts of Allium cepa, Allium sativum, Foeniculum vulgare, Matricaria chmomilla, Salvia offcinalis and Thymus Vulgaris showed strong antibacterial activity against MDR isolates with inhibition zones ranging from 8.33 to 26 mm. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the most active plant extracts; Allium cepa and Foeniculum vulgare were ranged from 0.062 to 0.25 mg/ml and 0.031 to 0.125 mg/ml, respectively . Foeniculum vulgare extract was bactericidal for all bacteria while Allium cepa extract was bacteriostatic. Hence, the discovered compounds from these plants can use as templates for the development of new antibacterial agents. DOI: http://dx.doi.org/10.3329/icpj.v4i1.21162 International Current Pharmaceutical Journal, December 2014, 4(1): 336-339","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"68 1","pages":"336-339"},"PeriodicalIF":0.0,"publicationDate":"2014-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90594867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Formulation and evaluation of dexamethasone loaded stearic acid nanoparticles by hot homogenization method. 热均质法制备负载地塞米松的硬脂酸纳米颗粒。

International Current Pharmaceutical Journal Pub Date : 2014-11-08 DOI: 10.3329/ICPJ.V3I12.20829

S. Parvin, Abu Shuaib Rafshanjani, A. Kader

{"title":"Formulation and evaluation of dexamethasone loaded stearic acid nanoparticles by hot homogenization method.","authors":"S. Parvin, Abu Shuaib Rafshanjani, A. Kader","doi":"10.3329/ICPJ.V3I12.20829","DOIUrl":"https://doi.org/10.3329/ICPJ.V3I12.20829","url":null,"abstract":"Dexamethasone is a type of steroid medication having anti-inflammatory and immunosuppressant effects. One of the major problems with this drug is its low solubility in water which results into poor bioavailability after oral administration. So the objective of the present work is to improve the solubility and dissolution rate of dexamethasone using its solid lipid nano particles (SLNPs) with stearic acid as solid lipid, lutrol F-68 as surfactant and tween-80 as stabilizer. SLNPs are prepared by hot homogenization method at different ratio of drug, lipid, surfactant and stabilizer and designated as DNP1 to DNP6. In vitro dissolution study was performed using the USP type II apparatus (paddle method) at 50 rpm to a temperature of 37°±0.5°C in distilled water containing 0.75% w/v SLS (sodium lauryl sulfate). The absorbance of sample was measured spectrophotometrically at λ max 239nm on a UV-Visible spectrophotometer. Release pattern of drug was found to follow zero order, first order and Korsmeyer-Peppas equations. Improvement of dissolution was observed in all the solid lipid nano particles as compared to pure drug. Pure drug showed only 27.25% release in 50 min whereas the dexamethasone SLNPs showed faster (66.19%) in vitro drug release. Hence, this finding indicates that dexamethasone SLNPs prepared by hot homogenization method can be used to enhance the dissolution rate and to show novel application to this drug delivery system. DOI: http://dx.doi.org/10.3329/icpj.v3i12.20829 International Current Pharmaceutical Journal, November 2014, 3(12): 331-335","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"24 1","pages":"331-335"},"PeriodicalIF":0.0,"publicationDate":"2014-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90062568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Preliminary evaluation of the suspending properties of Brachystegia eurycoma gum on metronidazole suspension 甲硝唑悬浮液对短齿木桉胶悬浮性能的初步评价

International Current Pharmaceutical Journal Pub Date : 2014-10-25 DOI: 10.3329/ICPJ.V3I11.20727

M. Uhumwangho, Ikechukwu Louis Ileje

{"title":"Preliminary evaluation of the suspending properties of Brachystegia eurycoma gum on metronidazole suspension","authors":"M. Uhumwangho, Ikechukwu Louis Ileje","doi":"10.3329/ICPJ.V3I11.20727","DOIUrl":"https://doi.org/10.3329/ICPJ.V3I11.20727","url":null,"abstract":"The aim of this study was to evaluate the suspending properties of Brachystegia eurycoma gum on metronidazole suspension. The suspending properties of Brachystegia eurycoma gum (family leguminosae ) were evaluated comparatively with that of compound tragacanth powder at concentration range of 2.5 – 10.0%w/v in metronidazole suspension. The following parameters were determined; sedimentation volume (%), viscosity, pH and re-dispersion number. The values obtained were used as basis for comparison of the suspending agents studied. Brachystegia eurycoma and compound tragacanth gums had a pH range between 4.7 to 4.9 and between 3.9 to 4.1 respectively which indicates that they are slightly acidic. Particles suspended with tragacanth gum at concentration ≤ 7.5%w/w redispersed easily than those formulated with the Brachystegia eurycoma gum at ≤ 10% w/w. It was observed that with increase in concentration of the gum the viscosity of the suspension increased correspondingly. For instance, at concentration of 2.5%w/w viscosities of the suspensions are 490 poise ( Brachystegia eurycoma gum) and 603 poise (compound tragacanth gum) while at concentrations of 7.5%w/w their viscosities were 914 poise ( Brachystegia eurycoma gum) and 1709 poise (compound tragacanth gum). There was a direct proportionality between viscosity of the gums at different concentrations and the sedimentation rate of the suspensions, as the viscosity of the gum increases, the rate of sedimentation of the suspension decreases. Brachystegia eurycoma gum at predetermined concentration can be exploited as an alternative excipient in the formulation of pharmaceutical suspensions of insoluble substances. DOI: http://dx.doi.org/10.3329/icpj.v3i11.20727 International Current Pharmaceutical Journal, October 2014, 3(11): 328-330","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"6 1","pages":"328-330"},"PeriodicalIF":0.0,"publicationDate":"2014-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82437667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Microbicidal activity of crude extracts from Sargassum wightii against Bacillus cereus 马尾草粗提物对蜡样芽孢杆菌的杀菌活性研究

International Current Pharmaceutical Journal Pub Date : 2014-09-05 DOI: 10.3329/ICPJ.V3I10.20338

Amritha Krishna Bhuvaneshwari Venugopal, V. Thirumalairaj, Geetha Durairaj, M. Vijayan, N. Lazar, Kavya Kurumboor Sathyan, Amrutha Chacko, Rincy Yesudas, Shasna Kadheeja, Ishara Kumari John David, S. J. Damascene

{"title":"Microbicidal activity of crude extracts from Sargassum wightii against Bacillus cereus","authors":"Amritha Krishna Bhuvaneshwari Venugopal, V. Thirumalairaj, Geetha Durairaj, M. Vijayan, N. Lazar, Kavya Kurumboor Sathyan, Amrutha Chacko, Rincy Yesudas, Shasna Kadheeja, Ishara Kumari John David, S. J. Damascene","doi":"10.3329/ICPJ.V3I10.20338","DOIUrl":"https://doi.org/10.3329/ICPJ.V3I10.20338","url":null,"abstract":"The present study was investigated to explore the antibacterial activity of four different solvent (petroleum ether, chloroform, acetone and ethanol) crude extracts of marine brown seaweed Sargassum wightti. Crude extracts were screened against human pathogen Bacillus cereus. The antibacterial efficiency was performed by agar well diffusion, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) methods . The results revealed that the crude extract of petroleum ether showed prominent inhibiting activity against B. cereus and other crude extracts showed below detectable level. The highest microbicidal activity (zone of inhibition) 9.0 ± 0.32 mm was obtained at the concentration of 250 μg /ml and the lowest activity was 3 ± 0.20 mm at 31.25 μg /ml concentration. The MIC and MBC values were found to be 125 and 250 μg /ml respectively. Results of this study suggested that the compounds present in the crude extracts of petroleum ether showed high activity against B. cereus and further studies are required to purify the active principles. DOI: http://dx.doi.org/10.3329/icpj.v3i10.20338 International Current Pharmaceutical Journal, September 2014, 3(10): 326-327","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"9 1","pages":"326-327"},"PeriodicalIF":0.0,"publicationDate":"2014-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87791824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Potential antibacterial activity of crude extracts and silver nanoparticles synthesized from Sargassum wightii 马尾藻粗提物及纳米银的潜在抗菌活性研究

International Current Pharmaceutical Journal Pub Date : 2014-09-05 DOI: 10.3329/ICPJ.V3I10.20337

V. Thirumalairaj, M. Vijayan, Geetha Durairaj, Lakshmanasenthil Shanmugaasokan, Rincy Yesudas, Suja Gunasekaran

{"title":"Potential antibacterial activity of crude extracts and silver nanoparticles synthesized from Sargassum wightii","authors":"V. Thirumalairaj, M. Vijayan, Geetha Durairaj, Lakshmanasenthil Shanmugaasokan, Rincy Yesudas, Suja Gunasekaran","doi":"10.3329/ICPJ.V3I10.20337","DOIUrl":"https://doi.org/10.3329/ICPJ.V3I10.20337","url":null,"abstract":"The present work investigates the antibacterial activity of silver nanoparticles (Ag-NPs) synthesized by biological method using Sargassum wightii . The fresh live seaweed was collected from the Mandapam coast of Tamilnadu, India. Solvent extract was prepared using acetone, petroleum ether and methanol. Aqueous extract of the seaweed was also used for the synthesis of silver Ag-NPs. Seaweed extract is used as a reducing agent of 2mM silver nitrate solution for the synthesis of Ag-NPs. Periodical monitoring of reaction mixture was done using UV-vis spectroscopy at 300-750 nm. The scanning electron microscopy (SEM) of the sample confirms the presence of Ag-NPs. The antibacterial activity of solvent extract was done by Minimal inhibitory concentration (MIC) assay. The methanol extract of the seaweed at a concentration of 250µg/ml exhibited potent antimicrobial activity against the test microorganism. The zone of inhibition ranging from 8-14 mm was observed with different extracts. The antibacterial activity of the synthesized Ag-NPs against the organism was also done by MIC test. The MIC of Ag-NPs was found to be 130µg/ml for all pathogenic microorganisms selected for the study. The zone of inhibition against Bacillus cereus, Bacillus anhtracis, Staphylococcus aureus and Vibrio alginoyticus were found to be 10, 8, 10 and 9 mm, respectively. The synthesized Ag-NPs exhibited significant antimicrobial activity against the selected microorganisms than the solvent extract of seaweed. DOI: http://dx.doi.org/10.3329/icpj.v3i10.20337 International Current Pharmaceutical Journal, September 2014, 3(10): 322-325","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"1 1","pages":"322-325"},"PeriodicalIF":0.0,"publicationDate":"2014-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76386678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Drug utilization study in orthopaedic units: Antibiotics prescribed in hospital out-patients in Dhaka, Bangladesh 骨科单位的药物利用研究:孟加拉国达卡医院门诊病人的抗生素处方

International Current Pharmaceutical Journal Pub Date : 2014-08-06 DOI: 10.3329/ICPJ.V3I9.19896

Seheli Sejuti Bithi, Md. Minhazur Rahman Khan, A. Khan

{"title":"Drug utilization study in orthopaedic units: Antibiotics prescribed in hospital out-patients in Dhaka, Bangladesh","authors":"Seheli Sejuti Bithi, Md. Minhazur Rahman Khan, A. Khan","doi":"10.3329/ICPJ.V3I9.19896","DOIUrl":"https://doi.org/10.3329/ICPJ.V3I9.19896","url":null,"abstract":"Antibiotics are generally prescribed for both as prophylactically (before orthopaedics surgery etc.) or to treat ongoing infection (like septic arthritis, osteomyelitis etc.) in the orthopaedics department. But if antibiotics are not use rationally then there will be increase chances of resistance of bacteria as also as deteriorate the patients’ disease condition which ultimately increase the total cost of treatment. The goal of this study was to see the antibiotics utilization pattern. A prospective cross-sectional, multicentre drug utilization study was conducted for a period of 3 months to evaluate the pattern of antibiotics use in orthopaedic unit of various hospitals of Dhaka City, Bangladesh. A total of 498 prescriptions were studied; in which 160 prescriptions contained mono-antibiotic therapy (51.79%) and 147 prescriptions contained poly-antibiotics therapy (48.21%) and the beta-lactam antibiotics were most commonly prescribed (81.68%). Mono-antibiotics prescriptions were the common pattern than combination and brand name has been prescribed frequently than generic. To minimize cost, it is advisable to promote prescription of generic drugs. Also justifying efforts are needed to improve appropriateness of antimicrobial therapy and minimize the development of antimicrobial resistance. Hence the results of the study showed that there is a considerable scope for improvement in the prescription pattern. DOI: http://dx.doi.org/10.3329/icpj.v3i9.19896 International Current Pharmaceutical Journal, August 2014, 3(9): 318-321","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"29 1","pages":"318-321"},"PeriodicalIF":0.0,"publicationDate":"2014-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72739523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Curriculum and Pharmacy practice experience offered for Pharm-D in Pakistan: needs and possibilities. 为巴基斯坦药学博士提供的课程和药学实践经验:需求和可能性。

International Current Pharmaceutical Journal Pub Date : 2014-07-05 DOI: 10.3329/ICPJ.V3I8.19406

M. Madiha, ChangYun Yang

引用次数: 6

Guideline adherence and control of diabetes mellitus with or without co-morbidities in various wards of a tertiary hospital in Malaysia 指南依从性和控制糖尿病有或没有合并症在马来西亚三级医院的各个病房

International Current Pharmaceutical Journal Pub Date : 2014-07-05 DOI: 10.3329/ICPJ.V3I8.19405

M. Iqbal, M. Iqbal, D. Nicholas, J. Awang, A. Khan, S. Sulaiman

{"title":"Guideline adherence and control of diabetes mellitus with or without co-morbidities in various wards of a tertiary hospital in Malaysia","authors":"M. Iqbal, M. Iqbal, D. Nicholas, J. Awang, A. Khan, S. Sulaiman","doi":"10.3329/ICPJ.V3I8.19405","DOIUrl":"https://doi.org/10.3329/ICPJ.V3I8.19405","url":null,"abstract":"To assess the adherence of physicians involved in the management of diabetes mellitus with or without co-morbidities with reference to Clinical Practice Guideline 2009given by Ministry of Health Malaysia in the tertiary care hospital, Pinang General Hospital Malaysia. Cross-sectional study was done at tertiary care hospital, Penang, Malaysia. The total 51physicians and 1020 patient’s prescriptions written by same physicians were taken from the record of the Penang General Hospital (20 prescriptions for each enrolled physician). All 1020 patients were suffering from diabetes mellitus with or without co-morbidities. These patients were recruited from the different wards of the Penang General Hospital. Depending on the recommendations of CPG 2009 the prescriptions of patients were divided into adherent and non-adherent prescriptions. The overall good level of physician adherence was seen with respect to the recommendations of CPG2009 in all prescriptions. A statistically significant negative association (Ф= 0.094, pvalue=0.003) was observed between diabetes mellitus control and co-morbidities. CPG adherent had statistically weak negative association (Ф= - 0.081, p-value=0.010) with patients having co-morbidities. No statistically significant association was observed between CPG adherence and any other co-morbidity. The study explored the several features of prescription pattern of physicians involved in the management of diabetes mellitus with or without co-morbidities and recognized the need for improvement in their prescription pattern for treating the diabetes mellitus.","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"30 1","pages":"309-312"},"PeriodicalIF":0.0,"publicationDate":"2014-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79540727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1