International Current Pharmaceutical Journal最新文献_第10页

Thymoquinone-loaded PLGA nanoparticles: antioxidant and anti-microbial properties 百里醌负载PLGA纳米颗粒:抗氧化和抗菌性能

International Current Pharmaceutical Journal Pub Date : 2013-11-14 DOI: 10.3329/ICPJ.V2I12.17017

Ilaiyaraja Nallamuthu, A. Parthasarathi, F. Khanum

{"title":"Thymoquinone-loaded PLGA nanoparticles: antioxidant and anti-microbial properties","authors":"Ilaiyaraja Nallamuthu, A. Parthasarathi, F. Khanum","doi":"10.3329/ICPJ.V2I12.17017","DOIUrl":"https://doi.org/10.3329/ICPJ.V2I12.17017","url":null,"abstract":"The aim of the present study was to synthesize and characterize the Thymoquinone (TQ) encapsulated PLGA (poly (dl-lactide-co-glycolide) nanoparticles, and further evaluate for its antioxidant and anti-bacterial activities. TQ is a potential active ingredient of Nigella sativa seed and possess a spectrum of therapeutic properties. Nanoparticles were prepared according to solid-in-oil-in-water (s/o/w) solvent evaporation method. Dynamic laser light scattering (DLS) and SEM studies indicated a mean particle size of < 200 nm. The success of encapsulation was confirmed by FTIR technique, and the encapsulation efficiency (EE) of TQ was determined to be 62%. In vitro drug release study showed a maximum release of TQ at 75% and 54 % respectively for artificial intestinal and gastric juices over the period of 7 days. DPPH radical scavenging activity of the nanoparticles was found to be 71% at 1 mg/ml concentration. It also exhibited antibacterial property against E. coli, Staphylococcus aureus and Salmonella typhi strains, tested using well diffusion method. In conclusion, our study shows that PLGA encapsulated TQ nanoparticle with sustained release property has preserved antioxidant as well as anti-microbial activity, and therefore suggesting its therapeutic applications in various food samples. DOI: http://dx.doi.org/10.3329/icpj.v2i12.17017 International Current Pharmaceutical Journal, November 2013, 2(12): 202-207","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"105 1","pages":"202-207"},"PeriodicalIF":0.0,"publicationDate":"2013-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74494839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 64

Prevalence of multidrug resistance in human pathogenic Staphylococcus aureus and their sensitivity to Allamanda cathartica L. leaf extract 人致病性金黄色葡萄球菌多药耐药率及其对泻泻草叶提取物的敏感性

International Current Pharmaceutical Journal Pub Date : 2013-10-08 DOI: 10.3329/ICPJ.V2I11.16525

MD AL Nayem Chowdhury, Nazmul Hossain, Mahbubur Rahman, Ashrafuzzaman

{"title":"Prevalence of multidrug resistance in human pathogenic Staphylococcus aureus and their sensitivity to Allamanda cathartica L. leaf extract","authors":"MD AL Nayem Chowdhury, Nazmul Hossain, Mahbubur Rahman, Ashrafuzzaman","doi":"10.3329/ICPJ.V2I11.16525","DOIUrl":"https://doi.org/10.3329/ICPJ.V2I11.16525","url":null,"abstract":"Staphylococcus aureus is one of the major pathogen responsible for skin infection, urinary tract infection (UTI) and endocarditis in human. The study was performed to determine the prevalence of multidrug resistant S. aureus in human clinical sample and to evaluate their sensitivity to Allamanda cathartica L. leaf extract. A total of 12 isolates were identified belongs to S. aureus by performing several physiological and biochemical tests. The isolates exhibited highest resistant (75%) to streptomycin and lowest (33.33%) against co-trimoxazole followed by disc diffusion assay of eight antibiotics tested. The other four antibiotics such as azithromycin, chloramphenicol, gentamycin and erythromycin exhibited 50 to 66.67% resistant to present isolates. Here we found that 75% of S. aureus isolates were multidrug-resistant (MDR). The crude leaf extract of A. cathartica L. found to possess antibacterial properties at the rate of 83.33% against S. aureus isolates with 12-22 mm zone of inhibition. Results of TLC states that Benzene : Ethyl acetate (1:1) solvent system was more effective for initial separation of compound from crude leaf extract resulted three distinct bands with different Rf values ranging from 0.53 to 0.89. The result of this study refers that A. cathartica L. leaf extract would be useful to develop effective drugs that would reduce the higher prevalence of multidrug resistance S. aureus causing clinical infection in human.","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"39 1","pages":"185-188"},"PeriodicalIF":0.0,"publicationDate":"2013-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74814294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative effects of different fractions of crude aqueous extract of Ficus exasperata leaves on blood pressure 恼怒榕叶粗水提物不同组分对血压的影响比较

International Current Pharmaceutical Journal Pub Date : 2013-10-08 DOI: 10.3329/ICPJ.V2I11.16534

A. K. Amonkan, A. B. Konan, L. K. Kouakou, M. N. Bleyere, M. K. Bouafou, S. Kati-coulibaly

{"title":"Comparative effects of different fractions of crude aqueous extract of Ficus exasperata leaves on blood pressure","authors":"A. K. Amonkan, A. B. Konan, L. K. Kouakou, M. N. Bleyere, M. K. Bouafou, S. Kati-coulibaly","doi":"10.3329/ICPJ.V2I11.16534","DOIUrl":"https://doi.org/10.3329/ICPJ.V2I11.16534","url":null,"abstract":"Ficus exasperata has been extensively used in folk medicine for the treatment of many ailments. The aqueous extract of leaves of this herb reduced blood pressure through its cholinomimetic effect. In this study, different fractions of the crude extract of F. exasperata leaves (FEFIX) were evaluated on blood pressure. Fractionated extracts were obtained by successive use of different solvents on the total crude extract. Phytochemical analysis was performed for each fraction and increasing doses (0.25 to 40 mg / kg b.w.) were administered intravenously. The phytochemical screening showed that alkaloids and phenols were found in ethanol fraction (FE-FEFIX) and methanol fraction (FM-FEFIX). Saponins and tannins have been identified only in the aqueous fraction (FA-FEFIX). Decreases in blood pressure were 40.02 ± 3.08 mm Hg for the ethanol fraction (FE-FEFIX), 9.95 ± 2.09 mm Hg for the methanol fraction (FM-FEFIX) and 5.26 ± 1.46 mm Hg in the aqueous fraction (FA-FEFIX). Hypotension induced by ethanol fraction is found to be greater than those induced by the other two fractions. In conclusion, this study showed that the hypotensive effect of F. exasperata leaves was greater with its ethanol extract. Alkaloids and phenols present in this extract may be involved in the hypotensive effect. DOI: http://dx.doi.org/10.3329/icpj.v2i11.16534 International Current Pharmaceutical Journal, October 2013, 2(11): 193-195","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"94 1","pages":"193-195"},"PeriodicalIF":0.0,"publicationDate":"2013-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83113410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Process optimization and eco-friendly/greener synthesis of some n-aryl/heteryl acetoacetamides 一些n-芳基/杂基乙酰乙酰胺的工艺优化及环保合成

International Current Pharmaceutical Journal Pub Date : 2013-10-08 DOI: 10.3329/ICPJ.V2I11.16533

K. Sirisha, I. Rajyalaxmi, S. Olivia

{"title":"Process optimization and eco-friendly/greener synthesis of some n-aryl/heteryl acetoacetamides","authors":"K. Sirisha, I. Rajyalaxmi, S. Olivia","doi":"10.3329/ICPJ.V2I11.16533","DOIUrl":"https://doi.org/10.3329/ICPJ.V2I11.16533","url":null,"abstract":"N-aryl/heteryl acetoacetamides are the intermediates used in the synthesis of various heterocyclic compounds like 1,4-dihydropyridines, pyrimidines etc. Three different substituted N-aryl/heteryl acetoacetamide derivatives (I-III) have been prepared from the reaction of ethylacetoacetate and three different aryl/heteryl primary amines under solvent free conditions using potassium tert- butoxide as catalyst. The reactions were carried out by two different methods ( viz. , Conventional and Microwave irradiation) and they are simple, eco-friendly and economical. All reactions were processed for optimization with different ratios of aryl/heteryl amine and ethylacetoacetate like1:1,1:1.2,1:1.4,1:1.6,1:1.8,1:2 and a comparison was made between the percentage yields with each ratio. Highest percentage yield was observed with 1:1.8 ratio for I & II and 1:1.6 ratio for III in both the methods. However, the microwave irradiation method was found to be superior to the conventional method. The newly synthesized compounds have been purified by recrystallization and characterized by physical and spectral data. DOI: http://dx.doi.org/10.3329/icpj.v2i11.16533 International Current Pharmaceutical Journal, October 2013, 2(11): 189-192","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"77 1","pages":"189-192"},"PeriodicalIF":0.0,"publicationDate":"2013-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74202601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Formulation development and evaluation of voriconazole sustained release tablets 伏立康唑缓释片的处方研制与评价

International Current Pharmaceutical Journal Pub Date : 2013-09-14 DOI: 10.3329/ICPJ.V2I10.16410

M. Rangasamy, Venkata Krishna Reddy Palnati, Lakshmi Narayana Rao Bandaru

{"title":"Formulation development and evaluation of voriconazole sustained release tablets","authors":"M. Rangasamy, Venkata Krishna Reddy Palnati, Lakshmi Narayana Rao Bandaru","doi":"10.3329/ICPJ.V2I10.16410","DOIUrl":"https://doi.org/10.3329/ICPJ.V2I10.16410","url":null,"abstract":"The present study involves in the formulation and evaluation of sustained release tablets of Voriconazole (250mg). The objective of the present study was to formulate Voriconazole sustained release tablets by wet granulation method by using natural (Xanthan gum, Karaya gum) and semi synthetic polymers (HPMC K100M). Lactose was used as diluting agent, Magnesium stearate was used as a lubricant and Talc was used as a glident. These sustained release tablets can release the drug up to 12 hours in predetermined rate. The formulated powder blend was evaluated for bulk density, tapped density, compressibility index and angle of repose. The formulated tablets were evaluated for physical characteristics of sustained release tablets such as thickness, hardness, friability, weight variation and drug content. The results of the formulations found to be within the limits specified in official books. The tablets were evaluated for In-vitro drug release studies by using USP type I dissolution test apparatus. The dissolution test was performed in 0.1 N HCL for 2 hr and phosphate buffer pH 6.8 for 10hrs. The in-vitro cumulative drug release profile of all formulations F1-F10 at 12 hours showed 84.25% to 99.82% drug release, respectively. From the data it was clear that by increasing the amount of polymer in the formulation the amount of drug release was decreased. Hence, Formulation F9 was the most promising formulation as it gives satisfactory release (99.82%) for 12 hours and F9 found to be the best formulation. DOI: http://dx.doi.org/10.3329/icpj.v2i10.16410 International Current Pharmaceutical Journal, September 2013, 2(10): 165-169","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"17 1","pages":"165-169"},"PeriodicalIF":0.0,"publicationDate":"2013-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78898810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Pyrethrin from Tanacetum cineriifoliun as repellent against mosquitoes 除虫菊酯的驱蚊作用

International Current Pharmaceutical Journal Pub Date : 2013-09-14 DOI: 10.3329/ICPJ.V2I10.16411

P. Amrutha, B. S. Priya, S. Lakshmanasenthil, A. Jenifer, L. Pillai, G. Suja, T. Vinothkumar

{"title":"Pyrethrin from Tanacetum cineriifoliun as repellent against mosquitoes","authors":"P. Amrutha, B. S. Priya, S. Lakshmanasenthil, A. Jenifer, L. Pillai, G. Suja, T. Vinothkumar","doi":"10.3329/ICPJ.V2I10.16411","DOIUrl":"https://doi.org/10.3329/ICPJ.V2I10.16411","url":null,"abstract":"The present study is conducted to find the efficacy of plant extracts to act as mosquito repellents. Initially, the larvicidal activity of the extracts and the toxicity study was conducted. From the results, the extracts with maximum larvicidal activity and the minimum toxicity were used for the further analysis. The least toxicity was observed with the ethanol extracts of Lantana camara , Tagetes erecta and Tanacetum cineriifolium . The Lanatana camara and Tanacetum cineriifolium showed the maximum larvicidal activity. The DNA sugar damage assay is performed and read at 532 nm. The hemolytic activity of the extract is conducted and the results indicate that the extracts showed no hemolytic activity at the concentration of 100 and 200mg/L. Only the flower extracts of Tagaetes erecta, Lantana camara and Tanacetum cineriifolium showed moderate hemolytic activity at 500 and 1000 mg/L. Finally, the HPLC analysis of the extracts showed that the ethanol extracts of Lantana camara and Tanacetum cineriifloium revealed the presence of marker compound. Therefore the ethanol extracts of Lantana camara and Tanacetum cineriifolium were taken up for the membrane stabilization assay. The skin irritation potential of the cream prepared using the ethanol extract of Tanacetum cineriifolium was analysed, the cream showed no irritation. DOI: http://dx.doi.org/10.3329/icpj.v2i10.16411 International Current Pharmaceutical Journal, September 2013, 2(10): 170-176","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"20 1","pages":"170-176"},"PeriodicalIF":0.0,"publicationDate":"2013-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81604458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Pharmacist interventions throughout care transitions: a review of current practices. 药剂师干预整个护理过渡:目前的做法回顾。

International Current Pharmaceutical Journal Pub Date : 2013-09-14 DOI: 10.3329/ICPJ.V2I10.16409

Julie A. Testman, A. Teichman, Stephen J. Cook, Angel M. Kimble, Brittany L. Riley, Jessica M. Robinson, B. Snodgrass

{"title":"Pharmacist interventions throughout care transitions: a review of current practices.","authors":"Julie A. Testman, A. Teichman, Stephen J. Cook, Angel M. Kimble, Brittany L. Riley, Jessica M. Robinson, B. Snodgrass","doi":"10.3329/ICPJ.V2I10.16409","DOIUrl":"https://doi.org/10.3329/ICPJ.V2I10.16409","url":null,"abstract":"Transitions of care occur each time a patient moves from one healthcare provider or care setting to another. Challenges that have been identified include: failure of the patient to keep appointments for outpatient chronic care; inability for smooth transfer of information between various healthcare providers; and failure to find appropriate placement for patients who can no longer manage independent living. As pharmacists representing an array of practice settings, these authors here present the models of contributions made by pharmacy services within such multifaceted approaches. An initial literature search was conducted using the National Library of Medicine via PubMed. Studies conducted in the United States that included at least one pharmacy service within the methods of intervention were selected for review. Where there are published findings from each setting, we include the measured impact, if reported. Although pharmacists represent the most skilled healthcare professionals in medication reconciliation and management, the best processes for tapping that expertise have yet to be fully elucidated. We present this review of current practices with the continued hope that the pharmacy profession will, not only continue to be the quiet patient advocate for best medication use, but also to open our minds to the need to measure, adjust, and measure again, the systems and processes we use to best integrate our knowledge for the overall benefit of the patient. DOI: http://dx.doi.org/10.3329/icpj.v2i10.16409 International Current Pharmaceutical Journal, September 2013, 2(10): 159-164","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"132 1","pages":"159-164"},"PeriodicalIF":0.0,"publicationDate":"2013-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80506640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial effect of fucoidan from Sargassum wightii against the chosen human bacterial pathogens 马尾藻褐藻聚糖对人体病原菌的抑菌作用

International Current Pharmaceutical Journal Pub Date : 2013-09-14 DOI: 10.3329/ICPJ.V2I10.16408

T. Marudhupandi, T. T. A. Kumar

引用次数: 65

Oral multiunit pellet extended release dosage form: A review 口服多单位微丸缓释剂型研究进展

International Current Pharmaceutical Journal Pub Date : 2013-09-14 DOI: 10.3329/ICPJ.V2I10.16413

V. Sachdeva, Shoaib Alam, Ramesh Kumar, M. Kataria

引用次数: 9

Assessment of analgesic and antipyretic activity of traditional formula used in the treatment of seasonal infections 传统方剂治疗季节性感染的镇痛解热作用评价

International Current Pharmaceutical Journal Pub Date : 2013-08-04 DOI: 10.3329/ICPJ.V2I9.16075

K. Parthiban, S. Natesan, G. Sekar, Krishnamoorthi Mahalakshm

{"title":"Assessment of analgesic and antipyretic activity of traditional formula used in the treatment of seasonal infections","authors":"K. Parthiban, S. Natesan, G. Sekar, Krishnamoorthi Mahalakshm","doi":"10.3329/ICPJ.V2I9.16075","DOIUrl":"https://doi.org/10.3329/ICPJ.V2I9.16075","url":null,"abstract":"Traditional treatments and medicines are the main sometimes the only source of health care for millions of people living in rural areas of developing countries. The aim of the present study is to investigate the analgesic and antipyretic activity of individual plant extracts and poly-herbal formula [PHF] made in to liquid dosage form of three different doses in albino rats. The plant materials were extracted in boiling distilled water for six hours, filtered, concentrated and dried. The aqueous extracts were prepared in to poly-herbal liquid dosage form by using water, glycerol mixture and acacia 2% in three different preparation of varying extract doses.1ml of above preparations orally fed for investigation. Pentozocine and paracetamol was used as standard drugs respectively. For individual plants the extracts were suspended in 2% acacia solution and performed. The results of analgesic and anti-pyretic activity of PHF 1 and PHF 2 showed significant results (P<0.01 and P<0.05 respectively) and PHF3 did not show any significant results. In the individual plant extracts slightly significant activity (P<0.05) was observed. DOI: http://dx.doi.org/10.3329/icpj.v2i9.16075 International Current Pharmaceutical Journal, August 2013, 2(9): 143-147","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"1553 ","pages":"143-147"},"PeriodicalIF":0.0,"publicationDate":"2013-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91457097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1