Comparative effects of different fractions of crude aqueous extract of Ficus exasperata leaves on blood pressure

International Current Pharmaceutical Journal Pub Date : 2013-10-08 DOI:10.3329/ICPJ.V2I11.16534

A. K. Amonkan, A. B. Konan, L. K. Kouakou, M. N. Bleyere, M. K. Bouafou, S. Kati-coulibaly

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引用次数: 2

Abstract

Ficus exasperata has been extensively used in folk medicine for the treatment of many ailments. The aqueous extract of leaves of this herb reduced blood pressure through its cholinomimetic effect. In this study, different fractions of the crude extract of F. exasperata leaves (FEFIX) were evaluated on blood pressure. Fractionated extracts were obtained by successive use of different solvents on the total crude extract. Phytochemical analysis was performed for each fraction and increasing doses (0.25 to 40 mg / kg b.w.) were administered intravenously. The phytochemical screening showed that alkaloids and phenols were found in ethanol fraction (FE-FEFIX) and methanol fraction (FM-FEFIX). Saponins and tannins have been identified only in the aqueous fraction (FA-FEFIX). Decreases in blood pressure were 40.02 ± 3.08 mm Hg for the ethanol fraction (FE-FEFIX), 9.95 ± 2.09 mm Hg for the methanol fraction (FM-FEFIX) and 5.26 ± 1.46 mm Hg in the aqueous fraction (FA-FEFIX). Hypotension induced by ethanol fraction is found to be greater than those induced by the other two fractions. In conclusion, this study showed that the hypotensive effect of F. exasperata leaves was greater with its ethanol extract. Alkaloids and phenols present in this extract may be involved in the hypotensive effect. DOI: http://dx.doi.org/10.3329/icpj.v2i11.16534 International Current Pharmaceutical Journal, October 2013, 2(11): 193-195

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恼怒榕叶粗水提物不同组分对血压的影响比较

恼怒榕在民间医学中被广泛用于治疗许多疾病。这种草药叶子的水提取物通过其胆碱模拟作用降低血压。在本研究中，研究了恼怒草叶粗提物(FEFIX)不同部位对血压的影响。通过对总粗提物连续使用不同的溶剂，得到了分馏提取物。对每个部分进行植物化学分析，并增加静脉注射剂量(0.25至40 mg / kg b.w.)。植物化学筛选表明，乙醇组分(FE-FEFIX)和甲醇组分(FM-FEFIX)中均含有生物碱和酚类物质。皂苷和单宁仅在水馏分(FA-FEFIX)中被鉴定出来。乙醇馏分(FE-FEFIX)血压降低40.02±3.08 mm Hg，甲醇馏分(FM-FEFIX)血压降低9.95±2.09 mm Hg，水馏分(FA-FEFIX)血压降低5.26±1.46 mm Hg。发现乙醇馏分引起的低血压明显高于其他两种馏分引起的低血压。综上所述，本研究表明，恼怒草叶乙醇提取物的降压作用更大。这种提取物中存在的生物碱和酚类物质可能参与降压作用。DOI: http://dx.doi.org/10.3329/icpj.v2i11.16534国际现代医药杂志，2013年10月，2(11):193-195

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International Current Pharmaceutical Journal

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