International Current Pharmaceutical Journal最新文献_第9页

Selection of an optimal method for the preparation of dual loaded flavono polymeric nanoparticle using analytical hierarchy process 用层次分析法选择制备双负载黄酮聚合物纳米颗粒的最佳方法

International Current Pharmaceutical Journal Pub Date : 2014-03-07 DOI: 10.3329/ICPJ.V3I4.18264

Senthilkumar Chinnamaruthu, M. Sellappan

{"title":"Selection of an optimal method for the preparation of dual loaded flavono polymeric nanoparticle using analytical hierarchy process","authors":"Senthilkumar Chinnamaruthu, M. Sellappan","doi":"10.3329/ICPJ.V3I4.18264","DOIUrl":"https://doi.org/10.3329/ICPJ.V3I4.18264","url":null,"abstract":"In this study, analytical hierarchy process was used to select an optimal method for the preparation of dual loaded flavono polymeric nanoparticles. Analytical hierarchy process involves structuring multiple choice criteria into a hierarchy, assessing the relative importance of criteria, comparing alternatives for each criterion and determining an overall ranking of the alternatives. Hierarchy model was developed with the goal in the first level, 10 criteria in the second level and methods for the preparation of polymeric nanoparticles in the third level. To assess the relative importance of criteria, all criteria were compared with each other using Saaty’s scale. To compare the methods, all the methods for the preparation of polymeric nanoparticles were compared with each other for each criterion using Saaty’s scale, which leads to the formation of pair-wise comparison matrixes and consistency ratio was calculated for the each pair-wise comparison matrix. The study result showed that the consistency ratio of each pair-wise comparison matrix were well within acceptable limits. Of 10 criteria, reproducible results received the maximum overall priority weight followed by desirable size. Of 10 methods, nanoprecipitation method received the maximum overall priority weight followed by supercritical fluid technology. Analytical hierarchy process has identified reproducible results as criteria preference and nanoprecipitation as an optimal method for the preparation of dual loaded flavono polymeric nanoparticles. The study concludes that the analytical hierarchy process has played a vital role in selecting an optimal method for the preparation of dual loaded flavono polymeric nanoparticles. DOI: http://dx.doi.org/10.3329/icpj.v3i4.18264 International Current Pharmaceutical Journal, March 2014, 3(4): 247-253","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"53 1","pages":"247-253"},"PeriodicalIF":0.0,"publicationDate":"2014-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86845886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Effect of synthetic super disintegrants and natural polymers in the preparation of donepezil hydrochloride fast disintegration films 合成强力崩解剂和天然聚合物对盐酸多奈哌齐快速崩解膜制备的影响

International Current Pharmaceutical Journal Pub Date : 2014-02-05 DOI: 10.3329/ICPJ.V3I3.17892

P. Lakshmi, D. Lavanya, M. Ali

{"title":"Effect of synthetic super disintegrants and natural polymers in the preparation of donepezil hydrochloride fast disintegration films","authors":"P. Lakshmi, D. Lavanya, M. Ali","doi":"10.3329/ICPJ.V3I3.17892","DOIUrl":"https://doi.org/10.3329/ICPJ.V3I3.17892","url":null,"abstract":"The main aim of the present research was to develop a fast dissolving oral polymeric film with good mechanical properties, faster disintegration and dissolution when placed on tongue. Donepezil hydrochloride (DPH) is prescribed in the treatment of mild to moderate Alzheimer’s disease (AD). The polymers selected for preparing films were sodium alginate (SA), poly vinyl alcohol (PVA) and guar gum (GG). Three batches of films were prepared by solvent casting method with sodium alginate, sodium alginate & PVA and with the combination of sodium alginate & guar gum. From these three batches, three optimized film formulations S3, SP7 and SG8 were selected based on disintegration time. To these three selected film formulations, superdisintegrants sodium starch glycolate (SSG), cross carmellose sodium (CCS) and cross povidone (CP) were added at a concentration of 4% w/w of polymer to improve the disintegration time. The films prepared with or without superdisintegrants were compared for fast releasing properties. Based on DT and in vitro dissolution data, S3CP was selected as the best formulation among the all formulations. DOI: http://dx.doi.org/10.3329/icpj.v3i3.17892 International Current Pharmaceutical Journal, February 2014, 3(3): 243-246","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"26 1","pages":"243-246"},"PeriodicalIF":0.0,"publicationDate":"2014-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89690012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Extraction, separation and identification of compounds from leaves of Solanum elaeagnifolium Cav. (Solanaceae) 龙葵叶中化合物的提取、分离与鉴定。(茄科)

International Current Pharmaceutical Journal Pub Date : 2014-02-05 DOI: 10.3329/ICPJ.V3I3.17890

Fakhri A. Elabbar, Nawil M. A. Bozkeha, Ashraf T.M. El-Tuonsia

{"title":"Extraction, separation and identification of compounds from leaves of Solanum elaeagnifolium Cav. (Solanaceae)","authors":"Fakhri A. Elabbar, Nawil M. A. Bozkeha, Ashraf T.M. El-Tuonsia","doi":"10.3329/ICPJ.V3I3.17890","DOIUrl":"https://doi.org/10.3329/ICPJ.V3I3.17890","url":null,"abstract":"Aim of the present study was to identify some phenolic compounds isolated from the dried powder leaves of Solanum Elaeagnifolium Cav. (Solanaceae family) collected from Benghazi area, Libya originally native in the Americas. The extraction was carried out with methanol at room temperature and treated by acidification (H 2 SO 4 , pH = 4) & basification (NH 4 OH, pH = 10). The compounds were separated by chromatographic method through a wet glass silica gel column and purification by medium pressure liquid chromatography (MPLC). The experiment yielded one novel compound named 2-(2-hydroxyphenoxy)-3,6,8-trihydroxy-4H-chromen-4-one [A 3 ] and three previously known phenolic which were isolated for the first time from this plant under study (Quercetin [A 1 ], Rutin [A 2 ] & Mangiferin [A 4 ]). The structures were determined using modern spectroscopic techniques (IR, EI-mass, 1 H-NMR, 13 C-NMR, APT, HMQC & COSY) using DMSO-d 6 solvent in magnetic resonance application. DOI: http://dx.doi.org/10.3329/icpj.v3i3.17890 International Current Pharmaceutical Journal, February 2014, 3(3): 234-239","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"37 1","pages":"234-239"},"PeriodicalIF":0.0,"publicationDate":"2014-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75847782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Effect of various extracts of Tabernaemontana divaricata on haloperidol induced catalepsy in rats 不同提取物对氟哌啶醇致大鼠猝厥的影响

International Current Pharmaceutical Journal Pub Date : 2014-02-05 DOI: 10.3329/ICPJ.V3I3.17891

C. Raj, A. Balasubramaniam, Sayyed Nadeem

引用次数: 2

Formulation and evaluation of potash alum as deodorant lotion and after shaving astringent as cream and gel 碳酸钾明矾除臭洗剂和剃须后收敛剂乳膏和凝胶的配方及评价

International Current Pharmaceutical Journal Pub Date : 2014-01-02 DOI: 10.3329/ICPJ.V3I2.17512

Abdulkarim K. Y. Alzomor, Ahmad Safe Moharram, N. Absi

{"title":"Formulation and evaluation of potash alum as deodorant lotion and after shaving astringent as cream and gel","authors":"Abdulkarim K. Y. Alzomor, Ahmad Safe Moharram, N. Absi","doi":"10.3329/ICPJ.V3I2.17512","DOIUrl":"https://doi.org/10.3329/ICPJ.V3I2.17512","url":null,"abstract":"Potash alum has different traditional application including deodorant and astringent. In order to wide advancement in development of pharmaceutical and cosmetic industries we preferred to work in this field as well as for improvement of safety and efficacy of traditionally used natural products. The aim of the present study was to formulate deodorant potash alum as lotion dosage form and astringent as cream and gel dosage forms. The activity of potash alum against axillaries normal microbiota was tested in vitro using wells diffusion agar method for different concentrations (0.1% to 9%) on Mueller Hinton (MH) agar and the minimum inhibitory concentration (MIC) was determined as 2% and also subculture was done to determine the activity of potash alum as bacteriostatic. Alum powder has wide traditional usage as astringent to prevent bleeding from minor cuts and for its accelerated healing. Therefore, a more appropriate dosage form was designed in a suitable concentration (2% gel) to elongate its astringent activity by its higher retention time due to highly viscous nature of gel. Using suitable excipients, 2% lotion and gel were prepared by dispersion method while emulsification was used for preparation of the potash alum cream of same strength. The above formulations were evaluated by comparing their pH, viscosity, spreadability, contents uniformity and in vitro diffusion. The stability study was carried out at 25°C for 3 months and at 40°C with 75±5% RH for one month. pH, viscosity, spreadability, extrudability and consistency of the products were evaluated at the end of the studies. The results indicated no change in the formulations demonstrating their stable nature as a dosage form and suitability as a commercial product line. DOI: http://dx.doi.org/10.3329/icpj.v3i2.17512 International Current Pharmaceutical Journal, January 2014, 3(2): 228-233","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"27 1","pages":"228-233"},"PeriodicalIF":0.0,"publicationDate":"2014-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77814010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Protective effect of Oroxylum indicum on acetaminophen induced liver injury in rat 芡实对对乙酰氨基酚所致大鼠肝损伤的保护作用

International Current Pharmaceutical Journal Pub Date : 2014-01-02 DOI: 10.3329/ICPJ.V3I2.17511

M. Bharali, H. Konya, Luk Bahadur Chetry

引用次数: 11

Antioxidant, cytotoxic and analgesic activities of the methanolic fruit extract of Terminalia chebula Retz. 慈母果甲醇提取物的抗氧化、细胞毒和镇痛活性。

International Current Pharmaceutical Journal Pub Date : 2013-12-09 DOI: 10.3329/ICPJ.V3I1.17296

Shammy Sarwar, Asif Malik, Muhammad Ashikur Rahman, Md Zakiur Rahman, M. Rana

{"title":"Antioxidant, cytotoxic and analgesic activities of the methanolic fruit extract of Terminalia chebula Retz.","authors":"Shammy Sarwar, Asif Malik, Muhammad Ashikur Rahman, Md Zakiur Rahman, M. Rana","doi":"10.3329/ICPJ.V3I1.17296","DOIUrl":"https://doi.org/10.3329/ICPJ.V3I1.17296","url":null,"abstract":"The present study was aimed to investigate antioxidant, analgesic and cytotoxic activity of the methanolic extract of Terminalia chebula Retz. fruits. Antioxidant potential of the extract was evaluated by using nitric oxide scavenging assay, reducing power and total antioxidant capacity. The extract showed significant activities in all antioxidant assays compared to ascorbic acid in a dose dependent mode. In nitric oxide scavenging assay, the IC 50 value of the extract was found to be 51.3 µg/mL while the IC 50 value of ascorbic acid was 77.4 µg/mL. In addition to strong reducing power, total antioxidant activity of the extract was also found to increase in a dose dependent manner. The analgesic activity was evaluated using acetic acid-induced writhing test in mice. The extract, at a dose of 500 mg/kg, showed a maximum of 44.17 % inhibition ( p < 0.05) of writhing reaction compared to the reference drug diclofenac-sodium (66.96 %). The extract also showed moderate cytotoxic activity in brine shrimp lethality bioassay and the LC 50 value was found to be 97.36 µg/mL. DOI: http://dx.doi.org/10.3329/icpj.v3i1.17296 International Current Pharmaceutical Journal, December 2013, 3(1): 219-222","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"28 1","pages":"219-222"},"PeriodicalIF":0.0,"publicationDate":"2013-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82004053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Validated TLC-densitometry method for determination of cetirizine dihydrochloride in tablet dosage form 用薄层色谱密度法测定片剂中盐酸西替利嗪的含量

International Current Pharmaceutical Journal Pub Date : 2013-12-09 DOI: 10.3329/ICPJ.V3I1.17294

Nia Kristiningrum, Ellsy Novita Martyanti

{"title":"Validated TLC-densitometry method for determination of cetirizine dihydrochloride in tablet dosage form","authors":"Nia Kristiningrum, Ellsy Novita Martyanti","doi":"10.3329/ICPJ.V3I1.17294","DOIUrl":"https://doi.org/10.3329/ICPJ.V3I1.17294","url":null,"abstract":"A rapid, reproducible and accurate TLC method was developed for the determination of Cetirizine Dihydrochloride in tablet. The analytes were dissolved with ethanol 70% and chromatographed on silica Gel GF 254 TLC plate using chloroform : methanol : ethyl acetate in the ratio of 2 : 7 : 3 (v/v) as mobile phase. Quantitative analysis was done through densitometric measurement at wavelength 234 nm. Method was found linear over the concentration range of 400 – 1600 ng/spot with the correlation coefficient of 0.996. Specificity showed calculation of purity and identity more than 0.99. The limit of detection (LOD) and the limit of quantification (LOQ) of the method were 75.54 and 226.64 ng/spot. The relative standard deviation of this method was 0.86% whereas the means of the recovery data was 100.54 ± 0.11%. The proposed method has been applied to the determination of Cetirizine Dihydrochloride in commercial tablet formulations and the result were 96.97 ± 0.86 % for brand A and 100.57 ± 1.17 % for brand B. The developed method was successfully used for the assay of Cetirizine Dihydrochloride. This method is simple, sensitive and precise; it can be used for the routine quality control testing of marketed formulations. DOI: http://dx.doi.org/10.3329/icpj.v3i1.17294 International Current Pharmaceutical Journal, December 2013, 3(1): 208-210","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"24 2 1","pages":"208-210"},"PeriodicalIF":0.0,"publicationDate":"2013-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82683321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Evaluation of cytotoxicity, anti-herpes simplex virus type 1 (HSV-1) and antibacterial activities of Ficus vasta and phytoconstituents 榕树及其植物成分的细胞毒性、抗1型单纯疱疹病毒(HSV-1)及抗菌活性评价

International Current Pharmaceutical Journal Pub Date : 2013-12-09 DOI: 10.3329/ICPJ.V3I1.17295

Kh. Rashed, L. Ono

{"title":"Evaluation of cytotoxicity, anti-herpes simplex virus type 1 (HSV-1) and antibacterial activities of Ficus vasta and phytoconstituents","authors":"Kh. Rashed, L. Ono","doi":"10.3329/ICPJ.V3I1.17295","DOIUrl":"https://doi.org/10.3329/ICPJ.V3I1.17295","url":null,"abstract":"This study deals with the evaluation of in vitro cytotoxicity of the methanol 80% extract of Ficus vasta aerial parts in Vero cells, anti-HSV-1 and antibacterial activities and the determination of the phytochemical content of the F. vasta methanol extract. The extract was tested for its cytotoxicity in Vero cells and for anti-HSV-1 and against bacterial strains as S. aureus , S. epidermidis , E. coli and P. aeruginosa and also phytochemical constituents were detected. The results showed that this extract presented a CC 50 value of 389 µg/mL, an intermediate value taking into account other researchers reported for some Moraceae species. Regarding the other biological activities, antiviral effect was not demonstrated by a HSV-1 challenge dilution of 100x tissue culture infective dose 50% (TCID 50 ) and also by the disk-diffusion method at the higher non-toxic concentration of the extract (119 µg/mL). Phytochemical analysis of the methanol extract proved the presence of carbohydrates, tannins, flavonoids, coumarins, alkaloids and triterpenes. Chromatographic separation of the methanol extract resulted in the isolation and identification of β -sitosterol, stigmasterol, lupeol, ursolic acid, naringenin, luteolin , quercetin, vitexin, quercetin 3- O-β -glucoside and rutin. The results indicated that F. vasta aerial parts methanol extract is potential candidate for experiments of biological activity screening that are not anti-HSV-1 or antibacterial against the strains evaluated in this study, to be carried on in the future. DOI: http://dx.doi.org/10.3329/icpj.v3i1.17295 International Current Pharmaceutical Journal, December 2013, 3(1): 211-218","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"20 1","pages":"211-218"},"PeriodicalIF":0.0,"publicationDate":"2013-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75408476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Formulation development and evaluation of Glibenclamide loaded Eudragit RLPO microparticles 载格列本脲的芡实RLPO微粒的研制与评价

International Current Pharmaceutical Journal Pub Date : 2013-11-14 DOI: 10.3329/ICPJ.V2I12.17016

B. P. Kumar, I. S. Chandiran, K. N. Jayaveera

{"title":"Formulation development and evaluation of Glibenclamide loaded Eudragit RLPO microparticles","authors":"B. P. Kumar, I. S. Chandiran, K. N. Jayaveera","doi":"10.3329/ICPJ.V2I12.17016","DOIUrl":"https://doi.org/10.3329/ICPJ.V2I12.17016","url":null,"abstract":"The objective of the present investigation was to formulate and evaluate microencapsulated Glibenclamide produced by the emulsion – solvent evaporation method. Microparticles were prepared using Eudragit RLPO by emulsion solvent evaporation method and characterized for their micromeritic properties, encapsulation efficiency, particle size, drug loading, FTIR, DSC, SEM analysis. In vitro release studies were performed in phosphate buffer (pH 7.4). Stability studies were conducted as per ICH guidelines. The resulting microparticles obtained by solvent evaporation method were free flowing in nature. The mean particle size of microparticles ranges from 134.49 – 179.72 µm and encapsulation efficiency ranges from 92.30-98.32%. The infrared spectra and differential scanning calorimetry thermographs confirmed the stable character of Glibenclamide in the drug-loaded microparticles. Scanning electron microscopy revealed that the microparticles were spherical in nature. In vitro release studies revealed that the drug release was sustained up to 12 hrs. The release kinetics of Glibenclamide from optimized formulation followed zero-order and peppas mechanism. The mechanism of drug release from the microparticles was found to be non-Fickian type. Eudragit RLPO microparticles containing Glibenclamide could be prepared successfully by using an emulsion solvent evaporation technique, which will not only sustain the release of drug but also manage complicacy of the diabetes in a better manner. DOI: http://dx.doi.org/10.3329/icpj.v2i12.17016 International Current Pharmaceutical Journal, November 2013, 2(12): 196-201","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"59 1","pages":"196-201"},"PeriodicalIF":0.0,"publicationDate":"2013-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78268223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10