Antioxidant, cytotoxic and analgesic activities of the methanolic fruit extract of Terminalia chebula Retz.

International Current Pharmaceutical Journal Pub Date : 2013-12-09 DOI:10.3329/ICPJ.V3I1.17296

Shammy Sarwar, Asif Malik, Muhammad Ashikur Rahman, Md Zakiur Rahman, M. Rana

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引用次数: 5

Abstract

The present study was aimed to investigate antioxidant, analgesic and cytotoxic activity of the methanolic extract of Terminalia chebula Retz. fruits. Antioxidant potential of the extract was evaluated by using nitric oxide scavenging assay, reducing power and total antioxidant capacity. The extract showed significant activities in all antioxidant assays compared to ascorbic acid in a dose dependent mode. In nitric oxide scavenging assay, the IC 50 value of the extract was found to be 51.3 µg/mL while the IC 50 value of ascorbic acid was 77.4 µg/mL. In addition to strong reducing power, total antioxidant activity of the extract was also found to increase in a dose dependent manner. The analgesic activity was evaluated using acetic acid-induced writhing test in mice. The extract, at a dose of 500 mg/kg, showed a maximum of 44.17 % inhibition ( p < 0.05) of writhing reaction compared to the reference drug diclofenac-sodium (66.96 %). The extract also showed moderate cytotoxic activity in brine shrimp lethality bioassay and the LC 50 value was found to be 97.36 µg/mL. DOI: http://dx.doi.org/10.3329/icpj.v3i1.17296 International Current Pharmaceutical Journal, December 2013, 3(1): 219-222

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慈母果甲醇提取物的抗氧化、细胞毒和镇痛活性。

本研究旨在探讨慈脑甲醇提取物的抗氧化、镇痛和细胞毒活性。水果。通过一氧化氮清除率、还原力和总抗氧化能力评价提取物的抗氧化潜力。与抗坏血酸相比，该提取物在所有抗氧化试验中均显示出显著的剂量依赖性。在一氧化氮清除实验中，发现提取物的IC 50值为51.3µg/mL，抗坏血酸的IC 50值为77.4µg/mL。除了较强的还原能力外，总抗氧化活性也呈剂量依赖性增加。用醋酸致小鼠扭体实验评价其镇痛活性。与对照药双氯芬酸钠(66.96%)相比，当剂量为500 mg/kg时，提取物对扭体反应的抑制率最高为44.17% (p < 0.05)。在盐水对虾致死生物试验中，该提取物具有中等的细胞毒活性，其lc50值为97.36µg/mL。DOI: http://dx.doi.org/10.3329/icpj.v3i1.17296国际现代医药杂志，2013年12月，3(1):219-222

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International Current Pharmaceutical Journal

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