International Current Pharmaceutical Journal最新文献

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Process optimisation, characterisation and evaluation of resveratrol-phospholipid complexes using Box-Behnken statistical design. 使用Box-Behnken统计设计对白藜芦醇-磷脂复合物进行工艺优化、表征和评价。
International Current Pharmaceutical Journal Pub Date : 2014-06-07 DOI: 10.3329/ICPJ.V3I7.19079
A. Agarwal, Vandana Kharb, V. Saharan
{"title":"Process optimisation, characterisation and evaluation of resveratrol-phospholipid complexes using Box-Behnken statistical design.","authors":"A. Agarwal, Vandana Kharb, V. Saharan","doi":"10.3329/ICPJ.V3I7.19079","DOIUrl":"https://doi.org/10.3329/ICPJ.V3I7.19079","url":null,"abstract":"With the advent of 21 st century, researchers worldwide have extensively reviewed herbs and botanicals for their marked clinical efficacy. It has been estimated that most of the newly discovered compounds offer poor bioavailability due to their low aqueous solubility. Phospholipid complexation of the drug often helps to improve its water solubility and enhance the bioavailability. This study includes optimization of resveratrol-phospholipid complexes using a 3-factor, 3-level box-behnken design (15 batches). Three independent variables i.e. phospholipid-resveratrol ratio, refluxing temperature and reflux time were optimized for two dependent variables, i.e. yield and entrapment efficiency (EE). Complexes were prepared by refluxing stoichiometric ratio of Phospholipon 90G and resveratrol in dichloromethane and retrieved by precipitation with n-hexane. Complexation was confirmed by Fourier Transform Infra-Red (FTIR) spectroscopy. The data was suitably used to explore quadratic response surfaces and construct second order polynomial models with Design Expert®. Formulation with highest desirability (D=0.994) was selected as optimum and prepared using 1.5:1 Phospholipon 90G-resveratrol ratio (X1) at 59.4°C temperature (X2) and 4 h time (X3) to give maximum yield and entrapment efficiency. Analysis of variance (ANOVA) was also found to be significant for both the responses. Complexes were optimised for good yield and EE. The partition coefficient was lowered to 2.25 hypothesizing good passive absorption. DOI:  http://dx.doi.org/10.3329/icpj.v3i7.19079 International Current Pharmaceutical Journal, June 2014, 3(7): 301-308","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"197 1","pages":"301-308"},"PeriodicalIF":0.0,"publicationDate":"2014-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75703398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 29
Development and validation of stability-indicating RP-UPLC method for simul-taneous estimation of thiocolchicoside and aceclofenac in combined dosage form. 稳定性指示RP-UPLC同时测定硫代秋糖苷和乙酰氯芬酸联合剂型的方法的建立与验证。
International Current Pharmaceutical Journal Pub Date : 2014-06-07 DOI: 10.3329/ICPJ.V3I7.19078
P. Balan, N. Kannappan
{"title":"Development and validation of stability-indicating RP-UPLC method for simul-taneous estimation of thiocolchicoside and aceclofenac in combined dosage form.","authors":"P. Balan, N. Kannappan","doi":"10.3329/ICPJ.V3I7.19078","DOIUrl":"https://doi.org/10.3329/ICPJ.V3I7.19078","url":null,"abstract":"A stability indicating RP-UPLC method was developed and validated for the simultaneous determination of Thiocolchicoside (TCC) and Aceclofenac (ACF) in tablet dosage form. The chromatographic separation was carried out by Thermo Scientific UPLC Instrument, Accela 1250 Pump, auto sampler with PDA detector, using column Thermo Scientific hypersil gold C 18 , (50 x 2.1mm) particle size 1.9µm using 5% ammonium acetate buffer and methanol in the ratio of 40:60, pH was adjusted to 5 with ortho phosphoric acid as mobile phase at a flow rate of 250 µl/min with the detection at 276nm. The run times of the TCC and ACF were about 0.697 and 1.125 minutes, respectively. The detector response is linear from 4.8 µg/ml to 7.2 µg/ml and 63.8 µg/ml to 96 µg/ml concentrations for TCC and ACF respectively. The linear regression equation was found to be y = 20620x-677.68 (r 2 = 0.9996) for TCC and y= 50931x-319.3 (r 2 = 0.9997) for ACF. The detection limit and quantification limit was 0.076µg and 0.23µg for TCC and 0.27µg and 0.71µg for ACF. The percentage of assay of TCC and ACF were about 99.50% and 99.96% respectively. The stability indicating capability was established by forced degradation experiments. The method was satisfactorily validated as per the ICH guidelines. DOI:  http://dx.doi.org/10.3329/icpj.v3i7.19078 International Current Pharmaceutical Journal, June 2014, 3(7): 296-300","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"62 1","pages":"296-300"},"PeriodicalIF":0.0,"publicationDate":"2014-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82379428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Effect of cigarette smoking on liver functions: a comparative study conducted among smokers and non-smokers male in El-beida City, Libya 吸烟对肝功能的影响:在利比亚El-beida市吸烟者和非吸烟者男性中进行的比较研究
International Current Pharmaceutical Journal Pub Date : 2014-06-07 DOI: 10.3329/ICPJ.V3I7.19077
K. S. Alsalhen, Rahab Dawood Abdalsalam
{"title":"Effect of cigarette smoking on liver functions: a comparative study conducted among smokers and non-smokers male in El-beida City, Libya","authors":"K. S. Alsalhen, Rahab Dawood Abdalsalam","doi":"10.3329/ICPJ.V3I7.19077","DOIUrl":"https://doi.org/10.3329/ICPJ.V3I7.19077","url":null,"abstract":"Tobacco use is widely spread throughout the world. The effect of smoking on human health are serious and in many cases, deadly. The present study was done to investigate the effect of cigarette smoking on some liver functions in male population in El-beida city, Libya. The study was carried out on thirty Libyan male smokers, who smoked at least 10 cigarettes per day for at least15 years. The group includes smokers with age range between 30-60 years. Non-smokers, (control, n= 30) group were collected with the same range of age for statistical comparison. The whole blood samples were drawn by venipuncture from each member and liver functions test were estimated by a kit method on automatic analyzer (Beckman BUN analyzer, USA). The results of the study revealed a significant increase of malondialdehyde (MDA), which is an indicator of lipid peroxidation and oxidative stress significantly increased in cigarette smokers in groups when compared with control group. While the plasma level of total protein, albumin and total bilirubin decreased during smoking. Cigarette smoking raised alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), plasma total cholesterol and triglycerides in smoker group when compared with non-smoker group. To conclude, cigarette smoking leads to oxidative stress by free radical generation by the mechanism of lipid peroxidation. Smoking exerts negative influence on liver functions test should be carefully interpreted, and further study on the mechanism of the effects is warranted. DOI:  http://dx.doi.org/10.3329/icpj.v3i7.19077 International Current Pharmaceutical Journal, June 2014, 3(7): 291-295","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"4 1","pages":"291-295"},"PeriodicalIF":0.0,"publicationDate":"2014-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72714755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 28
Development and in vitro evaluation of polyurethane microparticles as carrier for bevacizumab: an alternative treatment for retinopathy of prematurity. 聚氨酯微颗粒作为贝伐单抗载体的开发和体外评价:早产儿视网膜病变的替代治疗。
International Current Pharmaceutical Journal Pub Date : 2014-05-03 DOI: 10.3329/ICPJ.V3I6.18759
R. Albulescu, F. Borcan, C. Paul, I. Velea, M. Puiu
{"title":"Development and in vitro evaluation of polyurethane microparticles as carrier for bevacizumab: an alternative treatment for retinopathy of prematurity.","authors":"R. Albulescu, F. Borcan, C. Paul, I. Velea, M. Puiu","doi":"10.3329/ICPJ.V3I6.18759","DOIUrl":"https://doi.org/10.3329/ICPJ.V3I6.18759","url":null,"abstract":"Retinopathy of prematurity (ROP) is known as an abnormal development of the blood capillaries from the eyes’ retina, and it is met to those infants that were born too early (premature) as its name suggests. Bevacizumab or Avastin belongs to the class of monoclonal antibodies and it is a possible treatment for those patients who have been diagnosed with a recurrent malignant glioma or other cancers due to its behavior to bind selectively to vascular endothelial growth factor (VEGF). In this study, eye drops based on a polyurethane carrier used for bevacizumab were obtained and the degradation of this carrier was studied for three weeks in two different media: simulated body fluid (SBF) and phosphate buffered saline (PBS); the influence of ultrasounds on the degradation of polyurethane carrier was also evaluated. The obtained results suggest that the polyurethane carrier presents a very slow degradation which is beneficial for drugs which require low release rates and on the other hand, the concentrations of the degradation products remain at a low level. DOI:  http://dx.doi.org/10.3329/icpj.v3i6.18759 International Current Pharmaceutical Journal, May 2014, 3(6): 275-279","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"26 1","pages":"275-279"},"PeriodicalIF":0.0,"publicationDate":"2014-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84807584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Pharmacognostic and phytochemical investigation of young leaves of Triticum aestivum Linn. 小麦幼叶的生药学和植物化学研究。
International Current Pharmaceutical Journal Pub Date : 2014-05-03 DOI: 10.3329/ICPJ.V3I6.18760
G. Jain, A. Argal
{"title":"Pharmacognostic and phytochemical investigation of young leaves of Triticum aestivum Linn.","authors":"G. Jain, A. Argal","doi":"10.3329/ICPJ.V3I6.18760","DOIUrl":"https://doi.org/10.3329/ICPJ.V3I6.18760","url":null,"abstract":"ABSTRACT The aim of the work is to perform the pharmacognostic study of the leaves of plant Triticum aestivum Linn., Family Poaceae, commonly known as ‘Wheatgrass’. It is cultivated on large scale all over India and also occasionally cultivated in garden. For the present study samples of the Wheatgrass leaves were collected over a specific period of nine days. The drug was cultivated with specific type of hybrid seeds obtained from most reputed institution of India and were scrupulously analysed. For standardization of the herbal drug morphological, phytochemical, physicochemical and microscopical examination was done. The leaves grown were found to be lax, cauline, flat, 0.6 to 0.25 inches (4 to 6 mm) wide, 6-9 inches long and green in color. The chemical compositions of the leaves are proteins, flavonoids, alkaloids, glycosides, terpenoides, saponins, fibers, tannins and phenolic compounds. The specific variety of seeds, specific time of collection made it more specific to be used for further pharmacological studies. DOI:  http://dx.doi.org/10.3329/icpj.v3i6.18760 International Current Pharmaceutical Journal, May 2014, 3(6): 280-285","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"15 1","pages":"280-285"},"PeriodicalIF":0.0,"publicationDate":"2014-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80471273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Formulation and in-vitro bioequivalence evaluation of verapamil hydrochloride matrix tablets with Calan R 盐酸维拉帕米基质片的处方及体外生物等效性评价
International Current Pharmaceutical Journal Pub Date : 2014-05-03 DOI: 10.3329/ICPJ.V3I6.18761
I. Bashir, A. Sethi, M. Zaman, Junaid Qureshi, R. M. Sarfraz, Asif Mahmood, M. Sajid, Talha Jamshaid, M. Akram
{"title":"Formulation and in-vitro bioequivalence evaluation of verapamil hydrochloride matrix tablets with Calan R","authors":"I. Bashir, A. Sethi, M. Zaman, Junaid Qureshi, R. M. Sarfraz, Asif Mahmood, M. Sajid, Talha Jamshaid, M. Akram","doi":"10.3329/ICPJ.V3I6.18761","DOIUrl":"https://doi.org/10.3329/ICPJ.V3I6.18761","url":null,"abstract":"The purpose of the current work was to formulate Verapamil Hydrochloride (VH) sustained release matrix tablets by using natural polymers and comparison with leading national brand Calan SR of Searle Pharmaceuticals. Tragacanth and pectin were used in various concentrations. Pre compression studies i.e. angle of repose, bulk density, tapped density, Carr’s compressibility index and Hausner’s ratio were also performed and found within the Pharmacopoeial limits. Eight formulations (F1-F8) of (VH) were prepared by direct compression method. Post compression studies i.e. Thickness, Hardness, Diameter, Friability and Dissolution studies were conducted. Different kinetic models i.e. zero order, first order, Highuchi model and Korsmeyer Peppas were applied to study release patterns and similarity index was calculated. Dissolution studies were carried out in phosphate buffer of pH 6.8 showed that formulations (F4 and F8) formulated with higher polymers concentration showed comparatively better drug retardation. F5 was the most comparable with the reference product. Verapamil hydrochloride released was observed non-fickian as diffusion following Higuchi model.","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"38 1","pages":"286-290"},"PeriodicalIF":0.0,"publicationDate":"2014-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85023682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Development of lyophilization cycle for direct thrombin Inhibitor and influence of excipients and process parameter during the cycle. 直接凝血酶抑制剂冻干循环的研制及循环中辅料和工艺参数的影响。
International Current Pharmaceutical Journal Pub Date : 2014-04-08 DOI: 10.3329/ICPJ.V3I5.18533
S. Panda, Subas C. Dinda
{"title":"Development of lyophilization cycle for direct thrombin Inhibitor and influence of excipients and process parameter during the cycle.","authors":"S. Panda, Subas C. Dinda","doi":"10.3329/ICPJ.V3I5.18533","DOIUrl":"https://doi.org/10.3329/ICPJ.V3I5.18533","url":null,"abstract":"The objective of this study was to develop stable lyophilized product of Bivalirudin, a direct thrombin inhibitor with good reconstitution time, % yield of good vials and cake quality. The % loss of crystallinity was determined by DSC for any crystallographic changes of the bulking agent after freeze drying. The glass transition temperature of 5% w/v of Bivalirudin, 3% w/v of mannitol and 0.03% of sodium acetate was approximately ‑31°C and the collapse temperature was approximately -28°C. Tubular vials were found to withstand the thermal transition during freeze drying. Water content was inversely proportional to the primary drying set point. Reconstitution time was inversely proportional to annealing temperature and vacuum set point. The % yield of good vials and cake quality was directly proportional to annealing time and primary drying set point. The % loss of crystallinity by DSC was independent of all factors and directly proportional to annealing time. Drying at -10°C results in transition of β form of mannitol, whereas drying at -7.5°C and -5°C results in α and δ form of mannitol respectively. On annealing at -7°C for 54 minutes and drying at -6.5°C at 215mT lyophilized product with less than 2% water content, reconstitution time less than 10 seconds, with high yield of more than 95% yield of good vials with best cake quality was obtained. DOI:  http://dx.doi.org/10.3329/icpj.v3i5.18533 International Current Pharmaceutical Journal, April 2014, 3(5): 259-264","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"371 1","pages":"259-264"},"PeriodicalIF":0.0,"publicationDate":"2014-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84929783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatoprotective effect of Ecballium Elaterium fruit juice against paracetamol induced hepatotoxicity in male albino rats 白化雄性大鼠对扑热息痛肝毒性的保护作用
International Current Pharmaceutical Journal Pub Date : 2014-04-08 DOI: 10.3329/ICPJ.V3I5.18535
M. F. Elmhdwi, Saleh Mosbah Muftah, Salem G El Tumi, Fatma Al-zaroug Elslimani
{"title":"Hepatoprotective effect of Ecballium Elaterium fruit juice against paracetamol induced hepatotoxicity in male albino rats","authors":"M. F. Elmhdwi, Saleh Mosbah Muftah, Salem G El Tumi, Fatma Al-zaroug Elslimani","doi":"10.3329/ICPJ.V3I5.18535","DOIUrl":"https://doi.org/10.3329/ICPJ.V3I5.18535","url":null,"abstract":"This study was designed to investigate the antioxidant and hepatoprotective activity of Ecballium elaterium \"Fruit juice\" extract against paracetamol induced hepatotoxicity in male albino rats. The hepatotoxicity was induced by acetaminophen (PCM) at dose of 400 mg/kg in male albino rats. It was administered orally once a day , every 48 h at the same time for twenty two days. The biochemical liver functional tests ALT, AST, ALP, total bilirubin, total protein, antioxidant enzymes (GR, GPx, CAT, SOD), and histopathological changes were examined. Our results showed that Levels of liver enzymes ALT, AST, ALP, G-GT and total bilirubin and MDA level were significantly enhanced by administration of acetaminophen and level of total protein while antioxidant enzymes \"GR, GPx, CAT, SOD\" were decreased. However, the pretreatment with The E. elaterium \"fruit juice\" at 1 ml/kg orally revealed attenuation of serum ALT, AST, ALP. The histopathological studies also supported the protective properties of E. elaterium \"fruit juice\". The area of necrosis and degeneration of hepatocytes were observed in the toxic group. The prophylactic and curative groups showed a marked protective effect with decreased necrotic zones and hepatocellular degeneration. The present results clearly demonstrate the marked antihepatotoxic effects of E. elaterium \"fruit juice\" extract through its antioxidant activity on acetaminophen induced hepatotoxicity in rats. DOI:  http://dx.doi.org/10.3329/icpj.v3i5.18535 International Current Pharmaceutical Journal, April 2014, 3(5): 270-274","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"6 1","pages":"270-274"},"PeriodicalIF":0.0,"publicationDate":"2014-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79806176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Docking studies of Physalis peruviana ethanol extract using molegro virtual docker on insulin tyrosine kinase receptor as antidiabetic agent 胰岛素酪氨酸激酶受体与molegro虚拟对接剂对紫浆乙醇提取物的降糖剂对接研究
International Current Pharmaceutical Journal Pub Date : 2014-04-08 DOI: 10.3329/ICPJ.V3I5.18534
Ayik R. Puspaningtyas
{"title":"Docking studies of Physalis peruviana ethanol extract using molegro virtual docker on insulin tyrosine kinase receptor as antidiabetic agent","authors":"Ayik R. Puspaningtyas","doi":"10.3329/ICPJ.V3I5.18534","DOIUrl":"https://doi.org/10.3329/ICPJ.V3I5.18534","url":null,"abstract":"Physalis peruviana Linn in Indonesia was better known as ciplukan, based on information from urban people in Indonesia is as antidiabetic. In the previeous studies, the levels of blood glucose in animals experimental of Physalis peruviana quantified with glucometer and compared with oral antidiabetic drugs gliclazide, showed that Gliclazide was decrease more levels of glucose significantly than ethanol extract of Physalis peruviana . We have done molecular docking using Molegro Virtual Docker (MVD) on ethanol extract of Physalis peruviana and gliclazide to compare between in silico and in vivo studies. Based on studies before the main content of the ethanol extract of Physalis peruviana were withanolide, 4-OH-withanolide, and perulactone. In this study the results showed that gliclazide had been better bond in insulin tyrosine kinase receptor than main content of Physalis peruviana which can be seen from Moldock score 105.217 and Rerank score -68,2931 means that the energy was lower and more stable binding. Moldock Score of main content Physalis peruviana (withanolide, 4-OH-withanolide, and perulactone) were -93.5472; 70.5843; 88.7881, respectively. Rerank score of main content Physalis peruviana (withanolide, 4-OH-withanolide, and perulactone) were -61.5149; -67.5345; -65.7979, respectively. The hydrogen bonds of withanolide, 4-OH-withanolide, perulactone and gliclazide with amino acid of insulin tyrosine kinase receptor were Phe 1186 and Thr 1186. Finally, in the 3D MVD visualization between main content of ethanol extract of Physalis peruviana and gliclazide can be concluded that interaction of gliclazide was more harmonious than main content of ethanol extract Physalis peruviana . DOI:  http://dx.doi.org/10.3329/icpj.v3i5.18534 International Current Pharmaceutical Journal, April 2014, 3(5): 265-269","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"161 1","pages":"265-269"},"PeriodicalIF":0.0,"publicationDate":"2014-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74771900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Evaluation of anaphylactic reaction as an adverse event for perindopril erbumine tablets 培哚普利乙胺片过敏反应的不良反应评价
International Current Pharmaceutical Journal Pub Date : 2014-03-07 DOI: 10.3329/ICPJ.V3I4.18265
K. Krishnan, Kathiresan Krishnasamy
{"title":"Evaluation of anaphylactic reaction as an adverse event for perindopril erbumine tablets","authors":"K. Krishnan, Kathiresan Krishnasamy","doi":"10.3329/ICPJ.V3I4.18265","DOIUrl":"https://doi.org/10.3329/ICPJ.V3I4.18265","url":null,"abstract":"Perindopril erbumine is a tert-butylamine salt of perindopril used in the treatment of stable coronary artery disease and hypertension. The present study was aimed to evaluate the anaphylactic reaction as an adverse event for perindopril erbumine tablets. Electronic extraction of data from the safety database for this report includes all cases of anaphylactic reaction where perindopril was a primary or co-suspect drug. The study result have shown that there were overall 205 case reports for perindopril in the database, of which 200 cases were assessed as (potentially) perindopril and 05 were assessed as non-perindopril product. From the 200 case reports, 141 were serious and 59 were non-serious. Out of the 141 serious cases, 137 cases were medically confirmed while remaining 04 cases were consumer reports. Of the total 205 case reports there were five cases wherein the patient experienced anaphylactic reaction. The study concludes that three out of five cases entered in the drug safety database suggestive of a possible association between perindopril and anaphylactic reaction. DOI:  http://dx.doi.org/10.3329/icpj.v3i4.18265 International Current Pharmaceutical Journal, March 2014, 3(4): 254-258","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"135 1","pages":"254-258"},"PeriodicalIF":0.0,"publicationDate":"2014-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87580237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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