Microbiological evaluation of antibacterial potentiality of some edible plant extracts against multidrug resistant (MDR) human pathogens

International Current Pharmaceutical Journal Pub Date : 2014-12-06 DOI:10.3329/ICPJ.V4I1.21162

M. El-Sayed, B. Refaat, M. Sharaf

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引用次数: 2

Abstract

Antimicrobial resistance is a subject of great concern in public health and also in the designing of strategies for current therapeutic protocols all over the world. Plants used for traditional medicine contain a wide range of substances which can be used to treat various infectious diseases. Hence, antibacterial activities of aqueous extracts of 10 plant species were studied against 25 multidrug resistant (MDR) clinical isolates using the agar well diffusion method. The most resistant organisms were Acinetobacter baumanii (A. baumanii) (resistant to 16 different antibiotics), Enterococcus faecium (E. faecium) (resistant to 15 different antibiotics), Pseudomonas aeruginosa (P. aeruginosa) (resistant to 15 antibiotics), Gemella morbillorum (G. morbillorum) (resistant to 14 different antibiotics), Enterobacter cloacae (E. cloacae) (resistant to 13 different antibiotics) respectively. Among the tested plant extracts, only extracts of Allium cepa, Allium sativum, Foeniculum vulgare, Matricaria chmomilla, Salvia offcinalis and Thymus Vulgaris showed strong antibacterial activity against MDR isolates with inhibition zones ranging from 8.33 to 26 mm. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the most active plant extracts; Allium cepa and Foeniculum vulgare were ranged from 0.062 to 0.25 mg/ml and 0.031 to 0.125 mg/ml, respectively . Foeniculum vulgare extract was bactericidal for all bacteria while Allium cepa extract was bacteriostatic. Hence, the discovered compounds from these plants can use as templates for the development of new antibacterial agents. DOI: http://dx.doi.org/10.3329/icpj.v4i1.21162 International Current Pharmaceutical Journal, December 2014, 4(1): 336-339

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一些食用植物提取物对多重耐药(MDR)人类病原体抑菌潜力的微生物学评价

抗菌素耐药性是公共卫生和世界各地当前治疗方案策略设计中非常关注的主题。用于传统医学的植物含有多种物质，可用于治疗各种传染病。为此，采用琼脂孔扩散法研究了10种植物水提液对25株临床多药耐药菌株的抑菌活性。耐药最多的微生物分别是鲍曼不动杆菌(A. baumanii)(对16种不同抗生素耐药)、屎肠球菌(E. faecium)(对15种不同抗生素耐药)、铜绿假单胞菌(P. aeruginosa)(对15种抗生素耐药)、莫芽孢杆菌(G. morbillorum)(对14种不同抗生素耐药)、阴沟肠杆菌(E. cloacae)(对13种不同抗生素耐药)。在被试植物提取物中，只有葱、葱、小茴香、苦参、鼠尾草和胸腺提取物对MDR菌株具有较强的抑菌活性，抑菌带范围为8.33 ~ 26 mm。最有效植物提取物的最小抑菌浓度(MIC)和最小杀菌浓度(MBC);大蒜和小茴香的含量分别为0.062 ~ 0.25 mg/ml和0.031 ~ 0.125 mg/ml。小茴香提取物对所有细菌均有杀菌作用，葱提取物对所有细菌均有抑菌作用。因此，从这些植物中发现的化合物可以作为开发新型抗菌剂的模板。DOI: http://dx.doi.org/10.3329/icpj.v4i1.21162国际现代医药杂志，2014年12月，4(1):336-339

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International Current Pharmaceutical Journal

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