榛叶提取物及其组分的降糖尿病和降血脂作用

Asma Ahmed, M. Asad, M. Ahmad, R. Qureshi, Syed Imam Shah, H. Gul, M. Gulfraz
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引用次数: 7

摘要

糖尿病是最常见的人类疾病,在发展中国家,人们对植物治疗糖尿病的兴趣越来越大。本研究对苦楝提取物的抗糖尿病活性进行了分析。在白化小鼠Balb-C体内测试了不同植物部位的粗甲醇提取物对降低血糖、尿素、胆固醇、甘油三酯和糖化血红蛋白的作用。结果表明,窄叶姜对高血糖小鼠的血糖、糖化血红蛋白、甘油三酯和胆固醇具有较好的降血糖作用。以正己烷、乙酸乙酯、氯仿和水为溶剂萃取剂,对活性最高的芦笋叶提取物进行了进一步的分离,并测定了各组分的活性。发现乙酸乙酯部分在空腹和随机条件下降低血糖水平最有效,血糖降低效果与标准降糖药Glucophage相当。本研究表明,拉子叶提取物及其乙酸乙酯部分具有开发抗糖尿病药物的巨大潜力。DOI: http://dx.doi.org/10.3329/icpj.v4i2.21484国际现代医药杂志,2015年1月,4(2):353-361
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antidiabetic and hypolipidemic potential of Rhazya stricta Decne extract and its fractions
Diabetes mellitus is the most common human disease and there is growing interest for plant based therapy in managing diabetes mellitus specifically in the developing world. In the present study, Rhazya stricta Decne extract was analysed for its antidiabetic activities . Crude methanolic extracts of different plant parts were tested in vivo on albino mice Balb-C, for the reduction of blood glucose, urea, cholesterol, triacylglycerides and glycosylated haemoglobin. Results obtained showed that leaves of R. stricta have best antidiabetic effect by reducing blood glucose level, Glycosylated haemoglobin, triacylglycerides and Cholesterol in hyperglycaemic mice. The R. stricta leaves extract being most active was further fractionated by solvent extraction using n- Hexane, ethyl acetate, chloroform and water and all fractions were tested for same activities. It was found that ethyl acetate fraction is most effective in the reduction of blood glucose level at fasting and random conditions and blood glucose reduction was comparable to Glucophage, a standard antidiabetic drug. The present study suggests that Rhazya stricta leaves extract and its ethyl acetate fraction has great potential for development of antidiabetic drug. DOI:  http://dx.doi.org/10.3329/icpj.v4i2.21484 International Current Pharmaceutical Journal, January 2015, 4(2): 353-361
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