International Current Pharmaceutical Journal最新文献_第6页

Development and validation of UV-spectrophotometric methods for quantitative estimation of Prothionamide in pure and pharmaceutical dosage forms 紫外分光光度法测定纯剂型和药用剂型中丙硫胺含量的方法的建立和验证

International Current Pharmaceutical Journal Pub Date : 2015-06-06 DOI: 10.3329/ICPJ.V4I7.23590

S. Debnath, S. Saisivam, Dillip Kumar Dash, M. Debnath

引用次数: 6

FTIR spectroscopy for estimation of efavirenz in raw material and tablet dosage form FTIR光谱法测定依非韦伦原料药和片剂剂型

International Current Pharmaceutical Journal Pub Date : 2015-05-11 DOI: 10.3329/ICPJ.V4I6.23290

N. P. Reddy, Y. Padmavathi, P. Mounika, Akari Anjali

{"title":"FTIR spectroscopy for estimation of efavirenz in raw material and tablet dosage form","authors":"N. P. Reddy, Y. Padmavathi, P. Mounika, Akari Anjali","doi":"10.3329/ICPJ.V4I6.23290","DOIUrl":"https://doi.org/10.3329/ICPJ.V4I6.23290","url":null,"abstract":"A Fourier transform infrared (FTIR) spectrophotometric method was developed for rapid and direct measurement of efavirenz in pharmaceutical formulations. The method involves extraction of efavirenz from tablets with chloroform by sonication and the direct measurement of the absorbance in liquid phase using a reduced path length cell. In general, the spectrum was measured in transmission mode. The equipment was configured to collect a spectrum at 8 cm -1 resolution and 45 scans per sec .The spectra were collected between 4000 cm -1 and 450cm -1 , the band obtained at 1750cm -1 (carbonyl group) showed intense, clear peak in the liquid phase for quantitation. The method was validated as per ICH guidelines. The method fulfilled most validation requirements in the linearity range 200-1000µg/mL. The coefficient of determination, limit of detection and quantification was found to be 0.993, 49.12μg/mL and 148.84μg/mL respectively. Results of developed FTIR method were compared with the results obtained with the existing UV method statistically by using t-test, which indicated that there is no significant difference between the methods at P=0.05. The proposed FTIR method reduces the solvent consumption and also eliminates the use of reagents. Thus the developed method offers a good alternative for the quantitative estimation of efavirenz in bulk and pharmaceutical dosage forms and also to quantify efavirenz when combined with other API in the same dosage form. International Current Pharmaceutical Journal, May 2015, 4(6): 390-395","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"25 1","pages":"390-395"},"PeriodicalIF":0.0,"publicationDate":"2015-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83090569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Evaluation of cytotoxic and antioxidant activity of different fractions of methanolic extract of Baccaurea ramiflora (Lour.) fruits 花楸果实不同部位甲醇提取物的细胞毒性和抗氧化活性评价

International Current Pharmaceutical Journal Pub Date : 2015-05-11 DOI: 10.3329/ICPJ.V4I6.23288

R. Amin, M. N. Nabi

{"title":"Evaluation of cytotoxic and antioxidant activity of different fractions of methanolic extract of Baccaurea ramiflora (Lour.) fruits","authors":"R. Amin, M. N. Nabi","doi":"10.3329/ICPJ.V4I6.23288","DOIUrl":"https://doi.org/10.3329/ICPJ.V4I6.23288","url":null,"abstract":"Chloroform and petroleum ether soluble fractions of the crude methanolic extract of the fruits of Baccaurea ramiflora (Lour.) have been investigated for the evaluation of cytotoxic and antioxidant activity. Brine shrimp lethality bioassay was used to evaluate the cytotoxic activity and free radical scavenging activity method was used to evaluate antioxidant activity. In brine shrimp lethality bioassay, the chloroform soluble fraction showed greater cytotoxic activity (LC 50 value 74.2 µg/ml) than petroleum ether soluble fraction (LC 50 value 129 µg/ml) compared to the standard drug vincristine sulfate (LC 50 value 0.54 µg/ml). In free radical scavenging activity method (DPPH assay method), the chloroform soluble fraction showed greater antioxidant activity (IC 50 value 49.78 µg/ml) than petroleum ether soluble fraction (IC 50 value 75.31 µg/ml) compared to the standard antioxidant butylated hydroxytoluene (IC 50 value 24.51µg/ml). This study reveals that Baccaurea ramiflora fruit possesses cytotoxic and antioxidant activity hence can be a potential source for the isolation of active principle(s) for different therapies. International Current Pharmaceutical Journal, May 2015, 4(6): 386-389","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"57 1","pages":"386-389"},"PeriodicalIF":0.0,"publicationDate":"2015-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91141503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Determination of Flavonoid and Polyphenol Compounds in Viscum Album and Allium Sativum Extracts 芦荟和葱提取物中黄酮类和多酚类化合物的含量测定

International Current Pharmaceutical Journal Pub Date : 2015-04-04 DOI: 10.3329/ICPJ.V4I5.22861

Svetlana I. Trifunschi, M. Munteanu, Vlad Agotici, S. Pintea, R. Gligor

{"title":"Determination of Flavonoid and Polyphenol Compounds in Viscum Album and Allium Sativum Extracts","authors":"Svetlana I. Trifunschi, M. Munteanu, Vlad Agotici, S. Pintea, R. Gligor","doi":"10.3329/ICPJ.V4I5.22861","DOIUrl":"https://doi.org/10.3329/ICPJ.V4I5.22861","url":null,"abstract":"Ethnopharmacology is a new interdisciplinary science that appeared in Europe of the ‘90, in France, as a necessity claimed by the return to the traditional remedies of each nation. The aim of this study is to identify and quantify the active ingredients of the species Viscum album and Allium sativum , in order to provide a complex chemical characterisation, which is necessary for the use of these plants’ extracts as natural ingredients in the pharmaceutical industry. The following methods were used: (1) the plant material was harvested from the west-side of Romania (Europe) in July 2014; (2) it was dried quickly and the main active principles were extracted using ethylic alcohol solution (50%); (3) the quantitative analyses of the flavonoids and polyphenols were performed according to a procedure described in the Romanian Pharmacopoeia. FT-IR results showed that the Viscum album extract had the highest content of polyphenolic compounds, for both flavonoids and polyphenols. This is the reason why it can be concluded that alcoholic extracts of mistletoe must be used as supplements for diabetics who require diets with flavonoids or for patients with cancers, degenerative diseases, and particularly cardiovascular diseases, who need an increased amount of polyphenols. DOI: http://dx.doi.org/10.3329/icpj.v4i5.22861 International Current Pharmaceutical Journal, April 2015, 4(5): 382-385","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"31 1","pages":"382-385"},"PeriodicalIF":0.0,"publicationDate":"2015-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78047647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Development of new spectrophotometric method for estimation of tenofovir disoproxil fumarate using MBTH reagent MBTH试剂分光光度法测定富马酸替诺福韦二氧吡酯的新方法的建立

International Current Pharmaceutical Journal Pub Date : 2015-03-18 DOI: 10.3329/ICPJ.V4I4.22620

M. Varsha, N. R. Babu, Y. Padmavathi, P. Kumar

引用次数: 10

A comparative study for evaluating flurbiprofen effectiveness in postoperative pain 评价氟比洛芬对术后疼痛疗效的比较研究

International Current Pharmaceutical Journal Pub Date : 2015-02-07 DOI: 10.3329/ICPJ.V4I3.21935

Ibrahim Alreshidi, Yu Feng, Xie Han

{"title":"A comparative study for evaluating flurbiprofen effectiveness in postoperative pain","authors":"Ibrahim Alreshidi, Yu Feng, Xie Han","doi":"10.3329/ICPJ.V4I3.21935","DOIUrl":"https://doi.org/10.3329/ICPJ.V4I3.21935","url":null,"abstract":"Aim of the present study was to evaluate the effect of flurbiprofen, which is a member of non-steroidal anti-inflammatory drug group (NSAIDs), on postoperative pain treatment. From September 2013 to May 2014, total of 250 patients were surveyed to perform a systematic evaluation of postoperative pain by comparing flurbiprofen with two other kinds of NSAIDs (diclofenac and ketorolac) and isotonic saline in a double-blind, randomized, placebo-controlled study. Patients were randomized for treatment: 65 cases received flurbiprofen, 60 cases received diclofenac sodium, 60 cases received ketorolac and 65 cases received the placebo (0.9% isotonic saline) (control group). After 24-hours of surgery patients treated with flurbiprofen, ketorolac, and diclofenac showed the lowermost PPI scores compared with those treated with 0.9% isotonic saline (P<0.05). Moreover, flurbiprofen-treated patients also had the lowest PRI(R)T scores (P<0.05). When the pain rating index was examined by subclass, a significantly lower PRI(R)S score was detected in the flurbiprofen group at 24 hours (P<0.05). However, at the 96-hour time point, no differences that were found in PPI and PRI[R] scores between the ketorolac, diclofenac, and flurbiprofen groups, whereas the control group was significantly less effective than the NSAID drugs. Flurbiprofen seemed to be the most effective NSAID for the treatment of pain after internal fixation of fracture, even though at 24 hours after surgery pain was at a maximum. DOI: http://dx.doi.org/10.3329/icpj.v4i3.21935 International Current Pharmaceutical Journal, February 2015, 4(3): 367-369","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"IA-23 1","pages":"367-369"},"PeriodicalIF":0.0,"publicationDate":"2015-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84614352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causes, management and complications of ascites: a review 腹水的原因、处理和并发症综述

International Current Pharmaceutical Journal Pub Date : 2015-02-07 DOI: 10.3329/ICPJ.V4I3.21936

Hirra Tasneem, H. Shahbaz, Bushra Ali Sherazi

{"title":"Causes, management and complications of ascites: a review","authors":"Hirra Tasneem, H. Shahbaz, Bushra Ali Sherazi","doi":"10.3329/ICPJ.V4I3.21936","DOIUrl":"https://doi.org/10.3329/ICPJ.V4I3.21936","url":null,"abstract":"Ascites is the pathological state in which fluid accumulates in the peritoneal cavity. Fluid accumulation may be due to infection and malignancy or due to other diseases like liver disease, heart failure, and renal disease. The ascitic fluid can be graded into Transudative and Exudative fluid based on the serum ascites albumin gradient (SAAG). The prominent cause of ascites is found to be Liver Cirrhosis. The most common symptom of Ascites is recent weight gain, increased abdominal girth and dyspnea. The first line treatment of ascites includes education regarding dietary sodium restriction and oral diuretics. However, other mechanical methods can also be used if the patient is unresponsive to this approach. But, there are some limitations while using these mechanical methods. Ascites is also associated with certain complications like spontaneous bacterial perotinitis, hepatorenal syndrome and dilutional hyponatremia. Ascites itself is not fatal unless it becomes infected. So, early diagnosis and effective treatment should be ensured in order to avoid further complications. This review focuses on the grades, causes, symptoms, management and complications of Ascites. DOI: http://dx.doi.org/10.3329/icpj.v4i3.21936 International Current Pharmaceutical Journal, February 2015, 4(3): 370-377","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"45 1","pages":"370-377"},"PeriodicalIF":0.0,"publicationDate":"2015-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87534704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Pharmacist’s interventions in reducing the incidences of drug related problems in any practice setting 药剂师在任何实践环境中减少药物相关问题发生率的干预措施

International Current Pharmaceutical Journal Pub Date : 2015-01-07 DOI: 10.3329/ICPJ.V4I2.21483

Irsa Jamal, F. Amin, A. Jamal, A. Saeed

{"title":"Pharmacist’s interventions in reducing the incidences of drug related problems in any practice setting","authors":"Irsa Jamal, F. Amin, A. Jamal, A. Saeed","doi":"10.3329/ICPJ.V4I2.21483","DOIUrl":"https://doi.org/10.3329/ICPJ.V4I2.21483","url":null,"abstract":"A drug-related problem is an event or circumstance involving drug treatment that actually or potentially interferes with the patient’s experiencing an optimum outcome of medical care. The pharmacists can play key role in reducing the incidences of DRPs by making appropriate intervention at each stage and by working with other healthcare professionals. The aim of this study was to observe the Pharmacist clinical knowledge about DRPs and the extent to which they participate in reducing the incidences of DRPs. A questionnaire based survey was conducted among hundred pharmacists selected by random sampling in different health care settings from Lahore district. According to data collected it was found that 100% of Pharmacists had knowledge about DRPs and Pharmaceutical care. Different types of DRPs were identified by Pharmacists but only 41% of Pharmacists reported these DRPs and 37% of Pharmacists intervened to reduce the incidences of DRPs. Majority of the Pharmacists had knowledge about DRPs, other related terms and also about reporting but most of them did not actively participate to reduce incidences of DRPs because of lack of their acceptance by society and other health care professionals, lack of proper reporting system, lack of incentives and lack of time due to managerial job structure specially in case of retail pharmacy setup. DOI: http://dx.doi.org/10.3329/icpj.v4i2.21483 International Current Pharmaceutical Journal, January 2015, 4(2): 347-352","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"39 1","pages":"347-352"},"PeriodicalIF":0.0,"publicationDate":"2015-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86983365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Hypoglycemic property of cocoa products: potential underlying mechanisms 可可制品的降糖特性:潜在的潜在机制

International Current Pharmaceutical Journal Pub Date : 2015-01-07 DOI: 10.3329/ICPJ.V4I2.21485

A. S. Mubarak, Tang Yiquen

引用次数: 2

Pharmacoepidemiology of ascites and associated complications in hospitalized patients: descriptive observational study 住院患者腹水及相关并发症的药物流行病学:描述性观察性研究

International Current Pharmaceutical Journal Pub Date : 2015-01-07 DOI: 10.3329/ICPJ.V4I2.21482

Hirra Tasneem, H. Shahbaz, Bushra Ali Sherazi

{"title":"Pharmacoepidemiology of ascites and associated complications in hospitalized patients: descriptive observational study","authors":"Hirra Tasneem, H. Shahbaz, Bushra Ali Sherazi","doi":"10.3329/ICPJ.V4I2.21482","DOIUrl":"https://doi.org/10.3329/ICPJ.V4I2.21482","url":null,"abstract":"Ascites is the pathological accumulation of free fluid in peritoneal cavity. The aim of the present study was to observe the prevalence, clinical management and the assessment of complications associated with ascites in hospitalized patients. A Descriptive Observational Study was conducted at two tertiary care hospitals of Lahore. The data was collected on a data collection form containing questions regarding basic patient information, presenting symptoms, clinical management and associated complications. Verbal informed consent was taken and confidentiality was maintained. Pilot study was performed prior to performance of a full-scale research project. The results are expressed in the form of frequency and percentages. A total of fifty (50) ascitic patients were evaluated during two months. It was slightly more common in females (58%) as compared to males (42%). Common causes of Ascites were Liver Cirrhosis (80%), Chronic Renal Failure (10%), Peritoneal Malignancy and Peritoneal Tuberculosis (4%) each and Cardiac Failure (2%). The mainstay for the first line treatment in patients with cirrhosis includes education regarding dietary sodium restriction and oral diuretics. The major complications associated with Ascites were Protein malnutrition (87%), Mental Confusion (73%), Hepatorenal Syndrome (21%) and Spontaneous Bacterial Perotinitis (8%). In most patients ascites was being managed successfully by limiting the salt intake and provision of a diuretic regimen. As, ascites is a starting point for more serious complications; so, its early diagnosis should be ensured. Social media and NGOs should play their role in creating the awareness regarding this deadly disease. DOI: http://dx.doi.org/10.3329/icpj.v4i2.21482 International Current Pharmaceutical Journal, January 2015, 4(2): 343-346","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"32 1","pages":"343-346"},"PeriodicalIF":0.0,"publicationDate":"2015-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79682512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5