International Current Pharmaceutical Journal最新文献_第5页

Relationship between gestational diabetes and pregnancy induced hypertension (PIH). 妊娠期糖尿病与妊高征的关系。

International Current Pharmaceutical Journal Pub Date : 2015-10-05 DOI: 10.3329/ICPJ.V4I11.25236

S. Perveen, Q. Jabeen, M. Iqbal

引用次数: 5

Effect of HPMC and ethyl cellulose polymeric granules and its combinations in press coated tablets of lornoxicam: fabrication and in vitro characterization HPMC与乙基纤维素聚合物颗粒及其组合在氯诺昔康压片中的作用:制备及体外表征

International Current Pharmaceutical Journal Pub Date : 2015-09-08 DOI: 10.3329/ICPJ.V4I10.24914

S. Dineshmohan, V. Gupta, A. Ramesh, V. Harika, T. Sravani

{"title":"Effect of HPMC and ethyl cellulose polymeric granules and its combinations in press coated tablets of lornoxicam: fabrication and in vitro characterization","authors":"S. Dineshmohan, V. Gupta, A. Ramesh, V. Harika, T. Sravani","doi":"10.3329/ICPJ.V4I10.24914","DOIUrl":"https://doi.org/10.3329/ICPJ.V4I10.24914","url":null,"abstract":"The main objective of the present exploration was to formulate and evaluate chronomodulated press-coated tablets to deliver the NSAID lornoxicam, when a pain in the joints, functional disability persist in the early morning time is typically observed in most Rheumatoid arthritis (RA) patients. Pre formulation studies and drug excipient compatibility studies were carried out for lornoxicam and excipients. Core tablets containing lornoxicam was prepared by direct compression method and the tablets were subjected to various pre-compression and post-compression parameters (C1-C4 formula) based on the above result best core tablet batch was selected and used for press coating processes. HPMC and EC granules were used as controlled release polymers in the outer layer. These tablets were subjected to pre and post compression parameters, finally the tablets were evaluated for lag time and in vitro dissolution. Results of preformulation studies were acceptable limits. No interaction was observed between lornoxicam and excipients by FTIR. The results of pre and post compression studies were within limits. Formulation code CC3 was identified as best formulation that extends a release profile with 6 h lag time followed by complete lornoxicam release after 8 h. From the graphical representation it can be well perceive that this is perfectly fit in to Korsemeyer which had a Regression coefficient (R 2 ) of 0.9431. The results of the in-vitro release data of this layer were fitted to the Korsemeyer-Peppas equation to examine the release pattern of the drug from the polymeric system. The drug release was identified as super case II transport as the “n” value found to be more than 0.89. Dineshmohan et al., International Current Pharmaceutical Journal, September 2015, 4(10): 447-452","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"95 1","pages":"447-452"},"PeriodicalIF":0.0,"publicationDate":"2015-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80745672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Dissolution enhancement of glimepiride dispersion using glyceryl monostearate and β-cyclodextrin as carrier. 单硬脂酸甘油和β-环糊精为载体增强格列美脲分散体的溶出度。

International Current Pharmaceutical Journal Pub Date : 2015-09-08 DOI: 10.3329/ICPJ.V4I10.24912

Abu Shuaib Rafshanjani, Mofizur Rahman, S. Parvin, A. Kader

{"title":"Dissolution enhancement of glimepiride dispersion using glyceryl monostearate and β-cyclodextrin as carrier.","authors":"Abu Shuaib Rafshanjani, Mofizur Rahman, S. Parvin, A. Kader","doi":"10.3329/ICPJ.V4I10.24912","DOIUrl":"https://doi.org/10.3329/ICPJ.V4I10.24912","url":null,"abstract":"Glimepiride is an antidiabetic drug of sulfonylurea group and indicated for the treatment of type 2 diabetes mellitus. The present study was conducted to enhance the dissolution rate of glimepiride solid lipid nano particle dispersions using hot homogenization method and glimepiride solid dispersion by precipitation method. Solid lipid nanoparticles have been used as suitable carriers for delivery of drug with poor solubility. In this investigation glyceryl monostearate and stearic acid were used as solid lipid, Lutrol F-68 as surfactant, Tween 80 as stabilizer and the used polymer were urea crystal and β-cyclodextrin. Three formulations were prepared in different ratios for two methods and were designated as GMLN1 to GMLN3 in case of hot homogenization method and GMP1 to GMP3 for precipitation method. The evaluation of all the dispersions were done by in vitro dissolution studies using US Pharmacopeia type II apparatus (paddle method) in 900ml distilled water at 50 rpm to a temperature of 37°C ± 0.5°C for 45 minutes. In situ and externally sink method revealed the release pattern of drug was found to follow zero order, first order and Korsmeyer-Peppas equations. Improved dissolution profile was observed in all the solid lipid nano particle dispersions as compared to pure drug as well as market preparation. Thus, glyceryl monostearate and β-cyclodextrin can be successfully used as carrier for improvement of dissolution and bioavailability of glimepiride. Rafshanjani et al., International Current Pharmaceutical Journal, September 2015, 4(10): 436-441","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"13 1","pages":"436-441"},"PeriodicalIF":0.0,"publicationDate":"2015-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73828206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Pharmacognostical and phytochemical analysis of Lepidium sativum L. seeds. 枸杞种子的生药学和植物化学分析。

International Current Pharmaceutical Journal Pub Date : 2015-09-08 DOI: 10.3329/ICPJ.V4I10.24913

R. Ahmad, M. Mujeeb, F. Anwar, A. Husain, Aftab Ahmad, S. Sharma

{"title":"Pharmacognostical and phytochemical analysis of Lepidium sativum L. seeds.","authors":"R. Ahmad, M. Mujeeb, F. Anwar, A. Husain, Aftab Ahmad, S. Sharma","doi":"10.3329/ICPJ.V4I10.24913","DOIUrl":"https://doi.org/10.3329/ICPJ.V4I10.24913","url":null,"abstract":"Objective of the present study was to carry out the physicochemical and phytochemicals standardization of Lepidium sativum L seeds to establish the standard pharmacognostical parameters of this valuable medicinal plant. Many standardization parameters of Lepidium sativum were analyzed. Standard method was adopted for the preliminary phytochemicals screening. Analysis of pesticides residues, aflatoxin & heavy metals were also performed. The sections of seeds were prepared for quantitative microscopic parameters . The air dried powdered plant material was subjected for determination of physicochemical standardizations like ash value, Extractive value and fluorescence nature of the powder drug using light of short and long wavelength of 254nm and 366nm respectively. Phytochemical screening was performed for the identification of phytoconstituents in the plant which was helpful in the development of analytical profile. The morphological and microscopic examinations of drug were revealed the presence of endosperm cell which are polygonal in shape and contain alerone grains and oil droplet, cell of testa, yellow colouring matter and starch grains. Preliminary phytochemical screening showed the presence of carbohydrates, phenolic compounds, flavonoids, alkaloids, proteins, saponins and lipids in the drug extract and flourescence nature of drug was confirmed by fluorescence analysis in different solvent. Concentrations of heavy metals,ash value and extractive value were determined and found within acceptable Pharmacopoeial limits. Pesticides residues and aflatoxins were also determined but not detected in the tested samples. The physicochemical and phytochemical standards which are outcome of this research may be utilized as substantial data for identification and standardization of L. sativum seed. Ahmad et al., International Current Pharmaceutical Journal, September 2015, 4(10): 442-446","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"01 1","pages":"442-446"},"PeriodicalIF":0.0,"publicationDate":"2015-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86086920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Quality analysis of different marketed brands of paracetamol available in Bangladesh 孟加拉国不同市场品牌扑热息痛的质量分析

International Current Pharmaceutical Journal Pub Date : 2015-08-09 DOI: 10.3329/ICPJ.V4I9.24473

A. Kar, M. Amin, M. S. Hossain, Emdadul Hasan Mukul, Saif Uddin Rashed, Ibrahim

{"title":"Quality analysis of different marketed brands of paracetamol available in Bangladesh","authors":"A. Kar, M. Amin, M. S. Hossain, Emdadul Hasan Mukul, Saif Uddin Rashed, Ibrahim","doi":"10.3329/ICPJ.V4I9.24473","DOIUrl":"https://doi.org/10.3329/ICPJ.V4I9.24473","url":null,"abstract":"Paracetamol is a widely used analgesic and antipyretic drug worldwide. The present study was conducted to analyze the quality of seven marketed brands of paracetamol tablet formulation manufactured by different multinational and national companies. The tablet formulations of different brands were tested for various parameters like weight variation, hardness, friability, disintegration time and dissolution profile using standard techniques to evaluate their quality. The values were compared with the standards. Weight variation value requirement was complied by all brands. All studied samples except two local products complied with the standard specification for tablet hardness. All brands showed impressive friability values and products of multinational companies comparatively exhibited the highest values. Disintegration time for all brands was within 15 minutes also complying the USP (United State of Pharmacopeia) recommendation. Moreover, the release rate of different brands of paracetamol was satisfactory within 45 minutes and ranged from 79.82% to 103.53%. Therefore, it can be concluded that almost all the brands of paracetamol that are available in Bangladesh meet the USP specification for quality control analysis. Kar et al., International Current Pharmaceutical Journal, August 2015, 4(9): 432-435","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"78 1","pages":"432-435"},"PeriodicalIF":0.0,"publicationDate":"2015-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78143226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Formulation of fast disintegrating domperidone tablets using Plantago ovata mucilage by 3 2 full factorial design 采用32全因子设计以车前草黏液配制快速崩解多潘立酮片

International Current Pharmaceutical Journal Pub Date : 2015-07-06 DOI: 10.3329/ICPJ.V4I8.24023

S. Shahidulla, M. Khan, K. Jayaveera

{"title":"Formulation of fast disintegrating domperidone tablets using Plantago ovata mucilage by 3 2 full factorial design","authors":"S. Shahidulla, M. Khan, K. Jayaveera","doi":"10.3329/ICPJ.V4I8.24023","DOIUrl":"https://doi.org/10.3329/ICPJ.V4I8.24023","url":null,"abstract":"The present work was carried out to study the disintegrant property of plantago ovata mucilage . The objective of the work was to formulate Fast disintegrating tablets of Domperidon with a view to enhance patient compliances and dissolution rate by direct compression method using 3² full factorial design. Plantago ovata mucilage (2-10% w/w) was used as natural superdisintegrant and microcrystalline cellulose (0-30% w/w) was used as diluent, along with directly compressible mannitol to enhance mouth feel. The tablets were evaluated for hardness, friability, thickness, drug content uniformity, in vitro dispersion time, wetting time and water absorption ratio. Based on in vitro dispersion time (approximately 10s); the formulation containing 10% w/w Plantago ovata mucilage and 30%w/w microcrystalline cellulose was found to be promising and tested for in vitro drug release pattern (in 0.1 N HCl), short-term stability (at 40o/75% RH for 3 month) and drug-excipient interaction. Surface response plots are presented to graphically represent the effect of independent variables (concentrations of Plantago ovata mucilage and microcrystalline cellulose) on the in vitro dispersion time. The validity of the generated mathematical model was tested by preparing two extra-design check point formulations. The optimized tablet formulation was compared with conventional commercial tablet formulation for drug release profiles. This formulation showed nearly four-fold faster drug release (t 50% 2.85 min) compared to the conventional commercial tablet formulation (t 50% 7.85 min). Short-term stability studies on the formulation indicated that there are no significant changes in drug content and in vitro dispersion time (p < 0.05). Shahidulla et al., International Current Pharmaceutical Journal, July 2015, 4(8): 415-419","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"18 1","pages":"415-419"},"PeriodicalIF":0.0,"publicationDate":"2015-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83827661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Safety and Mechanism of Action of Licensed Vaccine Adjuvants 许可疫苗佐剂的安全性和作用机制

International Current Pharmaceutical Journal Pub Date : 2015-07-06 DOI: 10.3329/ICPJ.V4I8.24024

D. S. Rambe, G. Giudice, S. Rossi, Melvin Sanicas

{"title":"Safety and Mechanism of Action of Licensed Vaccine Adjuvants","authors":"D. S. Rambe, G. Giudice, S. Rossi, Melvin Sanicas","doi":"10.3329/ICPJ.V4I8.24024","DOIUrl":"https://doi.org/10.3329/ICPJ.V4I8.24024","url":null,"abstract":"Vaccines are some of the most effective tools for the prevention of infectious diseases. Adjuvants are included in vaccines for a variety of reasons: to increase the breadth of response, to lower antigen dose, to overcome limited immune response in some populations, or to enable complex combination vaccines. This study aims to review the safety of licensed vaccine adjuvants and describe their mechanism of action. Potential publications for inclusion were identified through a direct search of PubMed/Medline database. Results of online literature searches were supplemented by relevant papers cited in published studies along with the authors' knowledge of published studies. To date, there are 5 licensed vaccine adjuvants in US and Europe: Aluminum salts (EU, US), MF59 (EU), AS03 (EU), AS04 (EU, US), and virosomes (EU). AS03 is not available as an adjuvant in other vaccines but included within the US government's National Stockpile. All vaccines that contain these adjuvants have been proven safe in clinical trials and post-marketing studies, with the exception of the AS03, for which the rare events of narcolepsy have been reported in some countries. Every adjuvant has a complex and often multifactorial immunological mechanism, usually poorly understood in vivo. The safety profile of an adjuvant, including the actual and hypothetical risks, is a critical component that can speed up or impede adjuvant development. The increasing understanding in adjuvant sciences is fundamental to the further development of new adjuvants.","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"102 1","pages":"420-431"},"PeriodicalIF":0.0,"publicationDate":"2015-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80506486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Computational drug Cumintrazole-analog for the treatment of mutant BRCA1 and BRCA2 proteins in breast cancer 计算药物cumintrazole - analogue用于治疗乳腺癌中突变BRCA1和BRCA2蛋白

International Current Pharmaceutical Journal Pub Date : 2015-07-06 DOI: 10.3329/ICPJ.V4I8.24021

Shehneela Baseer, Sajid Khan, F. Nouroz

{"title":"Computational drug Cumintrazole-analog for the treatment of mutant BRCA1 and BRCA2 proteins in breast cancer","authors":"Shehneela Baseer, Sajid Khan, F. Nouroz","doi":"10.3329/ICPJ.V4I8.24021","DOIUrl":"https://doi.org/10.3329/ICPJ.V4I8.24021","url":null,"abstract":"Breast cancer is the second death causing disease in the world. Breast cancer gene 1 (BRCA1) and Breast cancer gene 2 (BRCA2) are the controlling proteins of this cancer. Real capacity of BRCA1/BRCA2 is to control the cell division, repair the damaged DNA and stabilized the genetic material of the cell. In case of any mutation in these proteins, the division of breast cells will be modified and therefore the cancerous development of cells will start in breast. The essential target of study was to prepare novel synthetic compound to focus on destinations for receptor proteins, located on cells surface, which control the development or stop the multiplication of cancer cells. Subsequent to screening vast measure of information, we outlined novel in-silico medication compound for breast cancer that is able to hinder the uncontrolled development of cells. In docked edifices PHE and GLN are critical communicating build ups for BRCA1 and BRCA2 proteins. Atomic recipe of shad sample totally fulfills the Lipinski rule of five. It shows less symptoms and long resistance against breast cancer cells. We infer that our medication shad sample is better than the business drugs available in business sector. As it is non-toxic in nature and has no reactions. The proposed drug is suitable for reduction of the breast cancer in females. Baseer et al., International Current Pharmaceutical Journal, July 2015, 4(8): 410-414","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"21 1","pages":"410-414"},"PeriodicalIF":0.0,"publicationDate":"2015-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80827354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Computational drug ZINPIP-Analog an ultimate solution to cure conserved domains of mutant EGFR, ALK and BRAF Proteins in NSCLC 计算药物zinip - analog是治愈非小细胞肺癌中突变EGFR、ALK和BRAF蛋白保守结构域的最终解决方案

International Current Pharmaceutical Journal Pub Date : 2015-06-06 DOI: 10.3329/ICPJ.V4I7.23589

Anum Munir, Sajid Khan, S. Azam

{"title":"Computational drug ZINPIP-Analog an ultimate solution to cure conserved domains of mutant EGFR, ALK and BRAF Proteins in NSCLC","authors":"Anum Munir, Sajid Khan, S. Azam","doi":"10.3329/ICPJ.V4I7.23589","DOIUrl":"https://doi.org/10.3329/ICPJ.V4I7.23589","url":null,"abstract":"Mutations in different genes such as EGFR, ALK and BRAF results in non-small cell Lung cancer (NSCLC). The most ordinarily discovered EGFR mutations in patients with NSCLC are deletion in exon 29 or in 21. Mutations initiate the tyrosine kinase activity of EGFR and are connected with the affectability to small molecules results in the formation of NSCLC. The missense mutations of BRAF have been detected in exon 11 and 15. Mutation of ALK occurs as a result of small inversion. The primary objective of study was to design novel chemical compound to block the targeted sites for receptor proteins, present on cells surface which control the growth or stop the proliferation of cancer cells. After screening large amount of data we have designed Novel Insillico drug compound Zinpip analog for NSCLC that blocks the EGFR, ALK, and BRAF. In docked complexes ALA, LYS, and ARG were common interacting residues for EGFR and ALK. ALA and GLY were common for ALK and BRAF mutant protein and Ligand complex interaction. ALA was common among all interactions. Molecular formula of Zinpip analog completely satisfies the Lipinski rules of five. It shows less side effects and long resistance against for non-small cell lung cancer. We conclude that our drug Zinpip analog is superior to commercial drugs available in market. As it is non-toxic in nature and has no side effects. International Current Pharmaceutical Journal, June 2015, 4(7): 396-401","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"71 1","pages":"396-401"},"PeriodicalIF":0.0,"publicationDate":"2015-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79264805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Antimicrobial property and phytochemical study of ginger found in local area of Punjab, Pakistan 巴基斯坦旁遮普当地生姜的抗菌特性和植物化学研究

International Current Pharmaceutical Journal Pub Date : 2015-06-06 DOI: 10.3329/ICPJ.V4I7.23591

H. Riaz, A. Begum, S. Raza, Z. Khan, H. Yousaf, A. Tariq

引用次数: 46