International Current Pharmaceutical Journal最新文献_第4页

In vivo Analgesic activity of methanolic extract of Helianthus annuus seeds 向日葵种子甲醇提取物的体内镇痛活性研究

International Current Pharmaceutical Journal Pub Date : 2016-03-15 DOI: 10.3329/ICPJ.V5I4.27019

R. Islam, Ahmed Tanjimul Islam, M. Hossain, K. Mazumder

引用次数: 10

Analytical method development and validation of Secnidazole in the tablet dosage form by RP-HPLC method 反相高效液相色谱法建立塞克硝唑片剂剂型的分析方法并进行验证

International Current Pharmaceutical Journal Pub Date : 2016-03-15 DOI: 10.3329/ICPJ.V5I4.27020

T. Sharmin, M. Akter, M. S. Hossain

引用次数: 5

Streptomyces: isolation, optimization of culture conditions and extraction of secondary metabolites 链霉菌的分离、培养条件优化及次生代谢产物的提取

International Current Pharmaceutical Journal Pub Date : 2016-02-06 DOI: 10.3329/ICPJ.V5I3.26695

A. Khattab, Eltahir H. Babiker, H. A. S. Supervisor

{"title":"Streptomyces: isolation, optimization of culture conditions and extraction of secondary metabolites","authors":"A. Khattab, Eltahir H. Babiker, H. A. S. Supervisor","doi":"10.3329/ICPJ.V5I3.26695","DOIUrl":"https://doi.org/10.3329/ICPJ.V5I3.26695","url":null,"abstract":"The objectives of this study were to isolate and identify Streptomyces from soil sediments as well as to optimize cultural growth conditions for maximum antibacterial productivity. A total of fifty soil sediments were collected from Red Sea, Sudan. The soil sediments were pretreated and cultivated on agar medium. Promising Streptomyces spp. were isolated by agar overlay method using indicator organisms. Optimization of chemical and physical culture conditions was carried out. The later was judged by assessment of antibacterial activity. Ethyl acetate was used to extract the secondary metabolite compounds. The separation of the active ingredients was performed using both thin layer chromatography (TLC) and gas chromatography-mass spectrometer (GC-MS). The results revealed nine strains of Streptomyces . Of them two (PS1 and PS28) isolates exhibited high activity against pathogenic bacteria. The optimum growth conditions were pH 7.5, temperature at 30°C, soyabean concentration 2.5 g/l, incubation period in 7 days, MgSO 4 .7H 2 O conc. 1g/l and K 2 HPO 4 conc. 2.5g/l. TLC test showed three and two fragments from metabolites of PS1 and PS28 respectively, while the GC-MS analysis revealed eight and eleven compounds with antibacterial activity of PS1 and PS28 respectively. It is concluded that marine is promising source of secondary metabolites. Khattab et al., International Current Pharmaceutical Journal, February 2016, 5(3): 27-32","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"120 1","pages":"27-32"},"PeriodicalIF":0.0,"publicationDate":"2016-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78023353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 48

A Comparative antimicrobial analysis of Tridax procumbens L. various extracts on waterborne bacterial pathogens 原藜不同提取物对水生病原菌抑菌效果的比较分析

International Current Pharmaceutical Journal Pub Date : 2016-02-06 DOI: 10.3329/ICPJ.V5I3.26694

M. Pandey, A. Pandey, R. Kumar, A. Pathak, A. Dikshit

引用次数: 3

Phytochemistry, pharmacological activities and traditional uses of Emblica officinalis: A review 黄刺属植物化学、药理活性及传统用途综述

International Current Pharmaceutical Journal Pub Date : 2016-01-18 DOI: 10.3329/ICPJ.V5I2.26441

M. R. Hasan, Md. Nasirul Islam, M. Islam

{"title":"Phytochemistry, pharmacological activities and traditional uses of Emblica officinalis: A review","authors":"M. R. Hasan, Md. Nasirul Islam, M. Islam","doi":"10.3329/ICPJ.V5I2.26441","DOIUrl":"https://doi.org/10.3329/ICPJ.V5I2.26441","url":null,"abstract":"From the ancient time, plants have been playing a key role for the betterment of mankind presenting as an extraordinary source of natural medicine. The complexity in formulating chemical based drugs as well as their health related side effects and uprising cost has led worldwide researchers to focus on medicinal plant research. Bangladesh has a vast repository of diverse plant species where about five thousand plants species have been claimed as having significant medicinal values. The researched papers on medicinal plants publishing from last few decades mention the activities of different plant bioactive compounds that are used widely in the treatment of various human ailments. Emblica officinalis is reported to possess bioactive compounds like tannins, flavonoids, saponins, terpenoids, ascorbic acids and many other compounds which are confirmed to have diverse pharmacological activities like antimicrobial, antioxidant, anti-inflammatory, radio-protective, hepatoprotective, antitissuive, immunomodulatory, hypolipedemic and many other activities. This medicinal plant is also reported to have anticancer, anti HIV-reverse transcriptase, antidiabetic, antidepressant, antiulcerogenic, wound healing activities and so forth. The current review paper summarizes the phytochemical constituents, pharmacological activities and traditional uses of the plant Emblica officinalis . Hasan et al., International Current Pharmaceutical Journal, January 2016, 5(2): 14-21","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"95 1","pages":"14-21"},"PeriodicalIF":0.0,"publicationDate":"2016-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79453668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 74

Novel core in cup (In-lay) tablets of lamotrigine for mucoadhesive drug delivery system 用于黏附给药系统的新型拉莫三嗪杯芯片

International Current Pharmaceutical Journal Pub Date : 2016-01-18 DOI: 10.3329/ICPJ.V5I2.26440

K. Srinija, P. Lakshmi

{"title":"Novel core in cup (In-lay) tablets of lamotrigine for mucoadhesive drug delivery system","authors":"K. Srinija, P. Lakshmi","doi":"10.3329/ICPJ.V5I2.26440","DOIUrl":"https://doi.org/10.3329/ICPJ.V5I2.26440","url":null,"abstract":"Lamotrigine a BCS class II drug used in treatment of epilepsy has several disadvantages when taken orally (first pass metabolism and increased C max ). The aim of the study is to design core in cup (In lay) buccoadhesive tablets which aims for controlled, unidirectional release, increased patient compliance and decreased side effects. The present study involves the preparation of core in cup tablets containing release retarding polymers like sodium alginate, xanthan gum and HPMC E 15LV in core and HPMC K 15M in cup for mucoadhesion. L9 orthogonal array Taguchi design was constructed for the study. The dependent variable studied for L9 orthogonal array Taguchi runs include % drug release from which the formulation with highest S/N ratio was optimized. All the runs were evaluated for physical parameters, drug release, mucoadhesive studies and assay. L1, L2, L4 and L8 formulations showed controlled release for up-to 8 hours with good assay values. The model dependent kinetics showed zero order kinetics with super case II transport and Hixson Crowell mechanism which indicates unidirectional drug release. Srinija and Lakshmi, International Current Pharmaceutical Journal, January 2016, 5(2): 9-13","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"3 1","pages":"9-13"},"PeriodicalIF":0.0,"publicationDate":"2016-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89234617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Central nervous system activity of the methanol extracts of Helianthus annuus seeds in mice model 向日葵种子甲醇提取物对小鼠中枢神经系统的影响

International Current Pharmaceutical Journal Pub Date : 2015-12-07 DOI: 10.3329/ICPJ.V5I1.25869

R. Islam, Ahmed Tanjimul Islam, M. Hossain, K. Mazumder

引用次数: 5

Vitamin D deficiency in children: A review on prevention and treatment strategy 儿童维生素D缺乏症:防治策略综述

International Current Pharmaceutical Journal Pub Date : 2015-12-07 DOI: 10.3329/ICPJ.V5I1.25870

Ibrahim Alreshidi

{"title":"Vitamin D deficiency in children: A review on prevention and treatment strategy","authors":"Ibrahim Alreshidi","doi":"10.3329/ICPJ.V5I1.25870","DOIUrl":"https://doi.org/10.3329/ICPJ.V5I1.25870","url":null,"abstract":"As an essential fat-soluble vitamin in human body, the main function of vitamin D (VD) is mediated by its receptor. In the past decade, VD has drawn gradual and consistent attention from the scientific community and health professionals. According to epidemiological survey, approximately one billion people are under the state of vitamin D insufficiency or deficiency in the world. This phenomenon is also very common in China. By participating in calcium and phosphorus absorption from GIT, VD stands as a very important functional immune regulator. It plays a vital role in modulating both innate and adaptive immune responses, mainly through the modulation of growth, differentiation and function of a variety of immune cells, and the influence of secretion of cytokines and antimicrobial peptides. VD deficiency and pediatric diseases such as acute lower respiratory infection and asthma are associated with not only pediatric skeletal disorders (including nutritional rickets，osteomalacla，and osteoporosis), but also pediatric non-skeletal disorders, such as mortality rate, cardiovascular disorders and mortality，metabolic syndrome (including obesity，impaired glucose tolerance (IGT), diabetes mellitus, lipid metabolism disorders and hypertension), cancer，infection，allergy and asthma, neurological and mental diseases，autoimmune diseases，and chronic kidney diseases. Although VD treatment of skeletal disorders has been widely recognized，its efficacy and long-term effect on non-skeletal disorders is not clear. Hence, for the benefit of general children and their families, aim of the present review is to determine some convincing facts of evidence-based medicine about Chinese children, and to discuss certain reasonable, right and effective measures to prevent VD deficiency thereby reducing the risk of rickets. Alreshidi, International Current Pharmaceutical Journal, December 2015, 5(1): 5-8","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"233 1","pages":"5-8"},"PeriodicalIF":0.0,"publicationDate":"2015-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75744969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The analysis of the effectiveness and safety of levofloxacin in the treatment of lower respiratory tract infection. 左氧氟沙星治疗下呼吸道感染的有效性和安全性分析。

International Current Pharmaceutical Journal Pub Date : 2015-11-07 DOI: 10.3329/ICPJ.V4I12.25598

Ibrahim Alreshidi, Khalid M. Al-Mutairi, Xie Han

{"title":"The analysis of the effectiveness and safety of levofloxacin in the treatment of lower respiratory tract infection.","authors":"Ibrahim Alreshidi, Khalid M. Al-Mutairi, Xie Han","doi":"10.3329/ICPJ.V4I12.25598","DOIUrl":"https://doi.org/10.3329/ICPJ.V4I12.25598","url":null,"abstract":"Objective of the current study was to investigate the effectiveness and safety of levofloxacin in the treatment of lower respiratory tract infection. The study was carried out in hospital on 120 patients with lower respiratory tract infection from January 2014 to January 2015. Patients were randomly divided into control and observation groups, each group contained 60 patients. The control group was given the routine dose of levofloxacin, whereas the observation group received the high dose of levofloxacin. The clinical effectiveness and incidence rate of untoward reactions between the two groups were statistically analyzed and evaluated. Patients’ cure rate in the observation group was 53.33%, significantly higher than that of the control group which was only 36.67%. Their differences have statistical significance (P 0.05). This study shows better clinical curative effect of high doses of levofloxacin treating lower respiratory infection with minimum risk. This method, which can significantly improve the quality of patient treatment with low adverse reaction risk, is worth popularizing in clinical use. Alreshidi et al., International Current Pharmaceutical Journal, November 2015, 4(12): 462-464","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"88 1","pages":"462-464"},"PeriodicalIF":0.0,"publicationDate":"2015-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85496077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and in vivo Anti-inflammatory and Analgesic activities of Oxadiazoles clubbed with Benzothiazole nucleus 苯并噻唑核棒状恶二唑的合成及其体内抗炎镇痛活性

International Current Pharmaceutical Journal Pub Date : 2015-11-07 DOI: 10.3329/ICPJ.V4I12.25597

Vishal Kumar, Saurabh Sharma, A. Husain

引用次数: 16