International Current Pharmaceutical Journal最新文献

{"title":"Chemical composition, antioxidant and antisalmonella activity of Mangifera indica L. flower and seed kernel extracts","authors":"V. Kamble, Dipali O. Somkuwar, S. J. Wankhade","doi":"10.3329/ICPJ.V5I10.29523","DOIUrl":"https://doi.org/10.3329/ICPJ.V5I10.29523","url":null,"abstract":"The extracts obtained from flower and seed parts of Mangifera indica L. were investigated for antioxidant and antisalmonella activities. Disc diffusion assay and broth macrodilution method were used to determine the antisalmonella activity. However, DPPH assay used to determine antioxidant activities of petroleum ether, chloroform, acetone and ethanol extracts of flower and seed kernel of Mangifera indica L. The mineral content of different parts of Mangifera indica L. was determined using ICP-OES method. Seed kernel and flower were found to be the rich source of Fe with the concentration of 660.50 and 221.75 µg per gram of dry weight. The antioxidant activity of the extracts was determined by DPPH free radical scavenging method. The petroleum ether extract of flower and ethanol extract of flower exhibited the most significant antisalmonella activity with the lowest MIC value of 8 mg/ml. The highest antioxidant activity was recorded in petroleum ether seed kernel and chloroform flower extract with the percentage inhibition of 86.64 ± 2.49 and 79.80 ± 1.28, respectively. Among all the tested combinations chloroform flower and ethanol seed kernel extracts showed greater synergistic effect along with tetracycline against Salmonella typhi isolates. Four different compounds with dual property of antioxidant and antisalmonella were isolated from the petroleum ether seed kernel and acetone flower extracts using thin layer chromatography. GC-MS analysis of acetonic flower extract showed the presence of 1, 2-Benzenedicarboxylic acid, isodecyl octyl ester (Synonym: Phthalic acid). Compounds Oleic acid and eicosyl ester were found in petroleum ether seed kernel extract. The present study revealed that identified compounds are responsible for exhibiting antioxidant and antisalmonella activities in flower and seed kernel. These findings may justify the conventional use of Mangifera indica L. in the treatment of typhoid fever. Kamble et al., International Current Pharmaceutical Journal, September 2016, 5(10): 82-93 http://www.icpjonline.com/documents/Vol5Issue10/02.pdf","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"37 1","pages":"82-93"},"PeriodicalIF":0.0,"publicationDate":"2016-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76954005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and determinants of hypertension among business class community of Lahore, Pakistan","authors":"M. Farooq, S. Rehmat, Ammara Ijaz Rana, M. Farooqui, M. Soban, R. Ali, A. Saleem, Usama Jamshaid, Rabail kanwal, K. Ullah, I. Bashir","doi":"10.3329/ICPJ.V5I10.29522","DOIUrl":"https://doi.org/10.3329/ICPJ.V5I10.29522","url":null,"abstract":"Hypertension is one of the leading health issue in developing countries. There are many factors associated with hypertension like obesity, excessive intake of salt, smoking and drinking alcohol. Current study aims to assess the prevalence and determinants of hypertension among business class community in Lahore. A community based survey in Lahore was conducted to evaluate the prevalence and determinants in business class community aged 20- 45 year. Questionnaire was designed, translated into local language and 400 participants were interviewed as per structured questionnaire, collected data was analyzed using statistical software SPSS 22. The prevalence of hypertension among study population was 37.5%. Results were astonishing only 32% of hypertensive patients were taking antihypertensive pills. Being overweight was strongly associated with hypertension, also excessive salt intake and sedentary life style were the contributing factors. There is dire need of awareness to be related hypertension among business class community counselling them about salt intake, smoking and regular exercise. Farooq et al., International Current Pharmaceutical Journal, September 2016, 5(10): 79-81 http://www.icpjonline.com/documents/Vol5Issue10/01.pdf","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"65 1","pages":"79-81"},"PeriodicalIF":0.0,"publicationDate":"2016-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84468442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, synthesis, molecular docking studies and anti-microbial activity of novel 1,2,3,4-tetrahydrocarbazole derivatives","authors":"S. Padmavathi, M. Tajne","doi":"10.3329/ICPJ.V5I9.29231","DOIUrl":"https://doi.org/10.3329/ICPJ.V5I9.29231","url":null,"abstract":"The heterocyclic compounds naming tetrahydrocarbazoles having the significant biological properties. The newly substituted tetrahydrocarbazole derivatives were prepared from substituted phenylhydrazine and cyclohexanone in glacial acetic acid under reflux. These intermediates on reaction with substituted aromatic acid chlorides in alkaline media finally converted to N-Substituted tetrahydrocarbazoles. Fifteen compounds are synthesized and characterized by their melting point (MP), IR, NMR, MS and elemental analysis. All the compounds were subjected to molecular docking studies for Gln-6-p enzyme (1XFF) inhibition. The results of in silico molecular docking showed that all the derivates have significant binding energies, good affinity with active pocket and it may be reflected as a good inhibitor of GlcN-6-P synthase. The anti-microbial activity was assessed by agar cup plate method and the result showed 8 compounds having the better anti-microbial response against the bacterial and fungal strains. In conclusion, the study helps to give the greater scope of developing these tetrahydrocarbazoles derivatives which help to promote the effective anti-bacterial agents. Padmavathi and Tajne, International Current Pharmaceutical Journal, August 2016, 5(9): 73-78 http://www.icpjonline.com/documents/Vol5Issue9/01.pdf","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"30 1","pages":"73-78"},"PeriodicalIF":0.0,"publicationDate":"2016-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73790784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Target Based Computational Drug Repositioning for Astrocytoma","authors":"M. Manzoor, I. Aslam, S. Azam, Zanib Khan","doi":"10.3329/ICPJ.V5I8.28874","DOIUrl":"https://doi.org/10.3329/ICPJ.V5I8.28874","url":null,"abstract":"Drug reposition is innovative method as it provides new ways to measure drug kinetics, multiplexed assays and others. In drug repositioning already approved drugs are used due to which time is not wasted on initial clinical trials. Market attainment cost for repositioned drugs is far less than the market attainment cost for new drugs. The secondary indications of most of the approved drugs and the availability of approved drug databases can provide an efficient way of searching safer drugs for new indications. Drug repositioning can provide an alternative method to explore the safe anti-cancer agents. Astrocytoma is the one type of Brain tumor. There are four types of Astrocytoma which arise in different part of the brain. The type IV that is Glioblastoma is very aggressive form of it. Many genes are involved in spreading of this disease but it is normally caused by Tp53. Mutations in the Tp53 gene are identified in about 28% of de novo GBM and 65% of secondary , thus indicating that Tp53 abnormalities are common in the progression of disease. The structure for Tp53 protein was obtained from RCSB PDB: RCSB Protein Data Bank. For repositioning Drugs are randomly selected from Drug Bank. Those drugs which have fewer side effects as compared to the drugs for Glioblastoma are selected as a candidate compounds for docking. Patch Dock server was used to perform molecular docking. Then among all selected drugs, some drugs are reposition on the basis of significant binding interactions with target protein TP53. Manzoor et al., International Current Pharmaceutical Journal, July 2016, 5(8): 63-68 http://www.icpjonline.com/documents/Vol5Issue8/01.pdf","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"191 1","pages":"63-68"},"PeriodicalIF":0.0,"publicationDate":"2016-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78315268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors of Cardiovascular Disease in Developing Countries","authors":"F. Rehan, Ali A. Qadeer, I. Bashir, Mohammed Jamshaid","doi":"10.3329/ICPJ.V5I8.28875","DOIUrl":"https://doi.org/10.3329/ICPJ.V5I8.28875","url":null,"abstract":"Cardiovascular diseases (CVDs) have increased the mortality rate both in developing as well as developed countries, however a lower trend in death rates have been seen in developed and high income countries like USA, UK, Australia, Japan and other European countries due to improved life style, better strategic implementation, control of disease both in young and adults and especially reduced smoking habits. In developing countries CVD become an alarming situation due to prevalence of disease in early age that later on become chronic and difficult to control. Various risk factors that can contribute toward CVD in developing countries include smoking, high alcohol and salt intake, dietary factors, diabetes, high blood pressure and psychosocial aspects such as stress, anxiety and depression. Various other factors such as family history and the gender difference also contributing towards the high risk of developing CVD. Rehan et al., International Current Pharmaceutical Journal, July 2016, 5(8): 69-72 http://www.icpjonline.com/documents/Vol5Issue8/02.pdf","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"8 1","pages":"69-72"},"PeriodicalIF":0.0,"publicationDate":"2016-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74008828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitive Determination of Cetirizine Using CdS Quantum dots as Oxidase Mimic-mediated Chemiluminescence of Sulfite","authors":"Reza Hoseinpour Kouhestany, S. N. Azizi, Parmis Shakeri, Shaghyegh Rahmani","doi":"10.3329/ICPJ.V5I7.28037","DOIUrl":"https://doi.org/10.3329/ICPJ.V5I7.28037","url":null,"abstract":"A new chemiluminescence (CL) method using cadmium sulfide quantum dots (QDs) as sensitizers is proposed for the chemiluminometric determination of cetirizine pharmaceutical formulation. CdS QDs were synthesized by using water soluble route. The nanoparticles were structurally and optically characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Ultra Violet-Visible (UV–Vis) absorption spectroscopy and scanning electron microscopy (SEM). In this study results shows that CdS quantum dots are enhancers of the weak CL emission. Trace amounts of cetirizine improved the sensitize effect of CdS quantum dots yielding a significant chemiluminescence enhancement of the Ce(IV)–SO 3 2− –CdS QDs system. So, a new CL analysis system was selected for the determination of cetirizine. There is a good linear relationship between the relative chemiluminescence intensity and the concentration of cetirizine in the range of 1×10 −9 – 1×10 −6 molL −1 with a correlation coefficient (R 2 ) of 0.9963 at the optimum conditions. The limit of detection (LOD) of this system was found to be 5×10 −11  M. This method is simple, sensitive and cost effective, and also is accommodating for pharmaceutical applications. Kouhestany et al., International Current Pharmaceutical Journal, June 2016, 5(7): 59-62","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"30 1","pages":"59-62"},"PeriodicalIF":0.0,"publicationDate":"2016-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80901045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reverse Phase HPLC Profiling of Antioxidant and Antimicrobial Activities of Sarcochlamys pulcherrima (Roxb.) Gaud.","authors":"Pradip Doley, N. M. Devi, C. Singh, Abhishekh Singh","doi":"10.3329/icpj.v5i6.27709","DOIUrl":"https://doi.org/10.3329/icpj.v5i6.27709","url":null,"abstract":"The total phenolics content, total flavonoids content, antioxidant activity and antimicrobial activity of methanol extract and its derived fractions from Sarcochlamys pulcherrima (Roxb.) Gaud. were evaluated. The plant material was initially extracted with methanol. The fractionation was carried out using liquid-liquid extraction with hexane, ethyl acetate, n-butanol, and water. The Folin-Ciocalteu assay was used to quantify total phenolics content, Aluminum Chloride assay to quantify total flavonoids content, DPPH (2, 2-diphenyl-1-picrylhydrazine) and reducing power assay are to determine antioxidant activity. The ethyl acetate fraction was observed to contain high phenolic content (201.37 mg/g) followed by n-butanol fraction (197.76 mg/g), methanol extract (136.93mg), water fraction (55.05mg/g) and hexane fraction (36.94mg/g) respectively. The flavonoids content ranges from 109.48 mg/g to 8.63 mg/g dry extract. The highest antioxidant activity was found in n-butanol fraction (EC 50 =14.69 µg/mL in DPPH and 162.65 µg/mL in reducing power). The antimicrobial activity of the samples was evaluated based on inhibition zone using agar-well diffusion assay and minimal inhibition concentration (MIC) values. Hexane fraction had no antimicrobial effect against test microorganisms. The zone of inhibitions ranged from 11 mm to 6 mm. The n-butanol fraction possessed the highest antimicrobial activity against E. coli among the four fractions with MIC value of 0.781mg/mL. In addition rutin, gallic acid, quercetin and kaempferol were quantified by reverse phase high performance liquid chromatography (HPLC) method. In ethyl acetate and n-butanol fraction, observed large amount rutin (77.53 ± 7.57 mg/g; 77.45 ± 1.71 mg/g) and gallic acid (61.01 ± 2.34 mg/g; 22.75 ± 1.54 mg/g) as compared to the quercetin and kaempferol. Doley et al., International Current Pharmaceutical Journal, May 2016, 5(6): 49-54","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"9 1","pages":"49-54"},"PeriodicalIF":0.0,"publicationDate":"2016-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85039052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Synthetic Nanozeolite Sodalite in Drug Delivery","authors":"Shaghayegh Rahmani, S. N. Azizi, N. Asemi","doi":"10.3329/ICPJ.V5I6.27710","DOIUrl":"https://doi.org/10.3329/ICPJ.V5I6.27710","url":null,"abstract":"In this study nanozeolite sodalite was synthesized from natural volcanic glass (perlite) as silica (Si) source and sodium aluminate as aluminium (Al) source without using any organic template. We use perlite as Si source because it is cost-effective and available source. These nanoparticles of synthesized zeolite were prepared at 170°C in stainless steel reactor with hydrothermal method. The synthesized nanozeolite was characterized by X-ray diffraction (XRD), fourier transform infrared (FTIR) and scanning electron microscopy (SEM) techniques. Chemical composition of perlite was determined by X-ray fluorescence (XRF).This nanozeolite was modified with cationic surfactant, hexadecyltrimethylammonium bromide (HDTMAB). In this study adsorption of cetirizine (Cet) as a model drug onto nanozeolite sodalite as a carrier of drug was investigated and Ultra Violet-Visible (UV-Vis) spectrophotometry was used for determination of concentrations of Cet at 230 nm. Adsorption characteristics of Cet on nanozeolite sodalite were examined at different times (0-6 h) and also the analysis was carried at three pH levels 4, 5 and 6. Finally three buffered solutions with different pH (1.2, 6.8 and 7.2) were selected for release medium and the temperature was precisely controlled at 37 ± 0.1°C. Rahmani et al., International Current Pharmaceutical Journal, May 2016, 5(6): 55-58","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"83 1","pages":"55-58"},"PeriodicalIF":0.0,"publicationDate":"2016-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90293592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing antibacterial activity of chitosan against Aeromonas hydrophila and Staphylococcus aureus","authors":"B. Erdem, E. Kariptaş, T. Kaya, Ş. Tulumoğlu, O. Gorgulu","doi":"10.3329/ICPJ.V5I5.27316","DOIUrl":"https://doi.org/10.3329/ICPJ.V5I5.27316","url":null,"abstract":"In this study, the effect of the incubation time, incubation temperature, pH, metal and sodium ions on the antibacterial activity of chitosan against food borne spoilage bacteria focused. Aeromonas hydrophila and Staphylococcus aureus were used as two food borne bacteria. Acetic acid was used dissolving of chitosan. Results showed that chitosan solution at 5 mg/mL significantly inhibited the growth of A. hydrophila and S. aureus in presence of time, pH and metal ions (p 0.01). Chitosan activity increased with increasing incubation time . The influence of below pH 6 on the antibacterial activity of chitosan was significantly influenced (p<0.01). The addition of Ba +2 reduced chitosan activity against A. hydrophila while the addition of Ca +2 have increased chitosan activity against S. aureus . Sodium ions at a concentration of 25 mM reduced chitosan activity against S. aureus . These results show that chitosan can be used food industry to prevent the development of spoilage bacteria. Erdem et al., International Current Pharmaceutical Journal, April 2016, 5(5): 45-48","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"26 1","pages":"45-48"},"PeriodicalIF":0.0,"publicationDate":"2016-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85685446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and evaluation of bio-nanoparticles as novel drug carriers for the delivery of Selegiline","authors":"L. Goswami, N. Madhav, K. Upadhyaya","doi":"10.3329/ICPJ.V5I4.27018","DOIUrl":"https://doi.org/10.3329/ICPJ.V5I4.27018","url":null,"abstract":"The purpose of the present study was to formulate and evaluate Selegiline loaded bio-nanoparticles for effective treatment of Depression. For the preparation of bio-nanoparticles biomaterial was isolated from fruits of Luffa acutangula by an economic method. The biomaterial recovered from the concentrate was subjected for various physicochemical properties like color, solubility, color changing point and chemical test. Bio-nanoparticles were prepared by modified solvent evaporation method in different batches with variable drug/biomaterial ratio. Prepared batches were subjected for various evaluation studies like particle size, zeta potential, SEM, TEM, surface entrapment, in-vitro diffusion, DSC and stability. Particle size and zeta potential result revealed that all nanoformulation were within range of 110 to 152.7 with slight negative in charge. SEM and TEM study report indicate that formulations were spherical in shape with less or no aggregation. Less surface entrapment leads to better drug entrapped inside nanomatrix. Bio-nanoformulations were capable of releasing the drug in a slow sustained manner. From the present investigation, it may be concluded that biomaterial isolated from fruits of Luffa acutangula used in the preparation of bio-nanoparticle act as an efficient carriers for deliver selegiline at a controlled rate. It may significantly improve the ability to cross blood-brain barrier and serve as an effective tool to treat Depression disease. Goswami et al., International Current Pharmaceutical Journal, March 2016, 5(4): 33-37 http://www.icpjonline.com/documents/Vol5Issue4/01.pdf","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"53 1","pages":"33-37"},"PeriodicalIF":0.0,"publicationDate":"2016-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76349877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}