Sensitive Determination of Cetirizine Using CdS Quantum dots as Oxidase Mimic-mediated Chemiluminescence of Sulfite

International Current Pharmaceutical Journal Pub Date : 2016-06-05 DOI:10.3329/ICPJ.V5I7.28037

Reza Hoseinpour Kouhestany, S. N. Azizi, Parmis Shakeri, Shaghyegh Rahmani

{"title":"Sensitive Determination of Cetirizine Using CdS Quantum dots as Oxidase Mimic-mediated Chemiluminescence of Sulfite","authors":"Reza Hoseinpour Kouhestany, S. N. Azizi, Parmis Shakeri, Shaghyegh Rahmani","doi":"10.3329/ICPJ.V5I7.28037","DOIUrl":null,"url":null,"abstract":"A new chemiluminescence (CL) method using cadmium sulfide quantum dots (QDs) as sensitizers is proposed for the chemiluminometric determination of cetirizine pharmaceutical formulation. CdS QDs were synthesized by using water soluble route. The nanoparticles were structurally and optically characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Ultra Violet-Visible (UV–Vis) absorption spectroscopy and scanning electron microscopy (SEM). In this study results shows that CdS quantum dots are enhancers of the weak CL emission. Trace amounts of cetirizine improved the sensitize effect of CdS quantum dots yielding a significant chemiluminescence enhancement of the Ce(IV)–SO 3 2− –CdS QDs system. So, a new CL analysis system was selected for the determination of cetirizine. There is a good linear relationship between the relative chemiluminescence intensity and the concentration of cetirizine in the range of 1×10 −9 – 1×10 −6 molL −1 with a correlation coefficient (R 2 ) of 0.9963 at the optimum conditions. The limit of detection (LOD) of this system was found to be 5×10 −11 M. This method is simple, sensitive and cost effective, and also is accommodating for pharmaceutical applications. Kouhestany et al., International Current Pharmaceutical Journal, June 2016, 5(7): 59-62","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"30 1","pages":"59-62"},"PeriodicalIF":0.0000,"publicationDate":"2016-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"8","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Current Pharmaceutical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3329/ICPJ.V5I7.28037","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 8

Abstract

A new chemiluminescence (CL) method using cadmium sulfide quantum dots (QDs) as sensitizers is proposed for the chemiluminometric determination of cetirizine pharmaceutical formulation. CdS QDs were synthesized by using water soluble route. The nanoparticles were structurally and optically characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Ultra Violet-Visible (UV–Vis) absorption spectroscopy and scanning electron microscopy (SEM). In this study results shows that CdS quantum dots are enhancers of the weak CL emission. Trace amounts of cetirizine improved the sensitize effect of CdS quantum dots yielding a significant chemiluminescence enhancement of the Ce(IV)–SO 3 2− –CdS QDs system. So, a new CL analysis system was selected for the determination of cetirizine. There is a good linear relationship between the relative chemiluminescence intensity and the concentration of cetirizine in the range of 1×10 −9 – 1×10 −6 molL −1 with a correlation coefficient (R 2 ) of 0.9963 at the optimum conditions. The limit of detection (LOD) of this system was found to be 5×10 −11 M. This method is simple, sensitive and cost effective, and also is accommodating for pharmaceutical applications. Kouhestany et al., International Current Pharmaceutical Journal, June 2016, 5(7): 59-62

查看原文本刊更多论文

CdS量子点模拟亚硫酸盐氧化酶化学发光法灵敏测定西替利嗪

提出了一种以硫化镉量子点为增敏剂的化学发光测定西替利嗪制剂的新方法。采用水溶性方法合成了CdS量子点。采用x射线衍射(XRD)、傅里叶变换红外光谱(FTIR)、紫外-可见(UV-Vis)吸收光谱和扫描电镜(SEM)对纳米颗粒进行了结构和光学表征。研究结果表明，CdS量子点是弱CL发射的增强剂。微量的西替利嗪改善了CdS量子点的敏化效果，使Ce(IV) - so32 -CdS量子点体系的化学发光增强。因此，选择了一种新的氯离子分析体系来测定西替利嗪。在最佳条件下，相对化学发光强度与西替利嗪浓度在1×10−9 ~ 1×10−6 mol / l−1范围内呈良好的线性关系，相关系数r2为0.9963。该系统的检出限(LOD)为5×10 - 11 m，该方法简便、灵敏、经济，适用于制药行业。Kouhestany等，国际药学杂志，2016,5(7):59-62

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Current Pharmaceutical Journal

自引率

0.00%

发文量