International Current Pharmaceutical Journal最新文献_第2页

Implementation of experimental design methodology in preparation and characterization of zolmitriptan loaded chitosan nanoparticles 佐米曲坦负载壳聚糖纳米颗粒制备及表征实验设计方法的实施

International Current Pharmaceutical Journal Pub Date : 2017-05-28 DOI: 10.3329/ICPJ.V6I3.32684

S. Mandlik, N. Ranpise

{"title":"Implementation of experimental design methodology in preparation and characterization of zolmitriptan loaded chitosan nanoparticles","authors":"S. Mandlik, N. Ranpise","doi":"10.3329/ICPJ.V6I3.32684","DOIUrl":"https://doi.org/10.3329/ICPJ.V6I3.32684","url":null,"abstract":"The present study investigated the implementation of 3 2 factorial design of experiment and statistical analysis for the optimization of chitosan nanoparticles containing zolmitriptan an antimigraine drug. The influence of chitosan concentration (X 1 ) and sodium tripoly phosphate (X 2 ) on responses namely nanoparticle size (Y 1 ), and entrapment efficiency (Y 2 ), was studied. As per design, nine runs of nanoparticles were prepared by modified ionic gelation method using high speed vortex mixing. The particle size was found in the range of 151-880 nm and entrapment efficiency was 72.3-81.2%. A statistical analysis was performed using licensed design expert software V.8.0 with respect to ANOVA, regression analysis. The contour plots and response surface plots showed visual representation of relationship between the experimental responses and the set of independent variables. Regression model equations were validated by a numerical and graphical optimization method. Further, optimized drug loaded nanoparticles showed +23.7mV zeta potential indicating storage stability, electron micrograph reflects spherical shape and mixed type of drug release followed by Fickian diffusion (n=0.266) was observed. Thus, using systematic factorial design approach, desirable goals can be achieved in shortest possible time with lesser number of experiments which was proven to be an effective tool in quality by design. Mandlik and Ranpise, International Current Pharmaceutical Journal, February 2017, 6(3): 16-22 http://www.icpjonline.com/documents/Vol6Issue3/01.pdf","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"29 1","pages":"16-22"},"PeriodicalIF":0.0,"publicationDate":"2017-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82809279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Designing of nanosized bioflavonoids using biodegradable polymeric nanoparticles by Plackett Burman method 利用可降解聚合物纳米颗粒设计纳米生物类黄酮

International Current Pharmaceutical Journal Pub Date : 2017-01-15 DOI: 10.3329/ICPJ.V6I2.31133

Nandhakumar Loganathan, M. Sellappan

{"title":"Designing of nanosized bioflavonoids using biodegradable polymeric nanoparticles by Plackett Burman method","authors":"Nandhakumar Loganathan, M. Sellappan","doi":"10.3329/ICPJ.V6I2.31133","DOIUrl":"https://doi.org/10.3329/ICPJ.V6I2.31133","url":null,"abstract":"In this present study, dual loaded flavono nanoparticulate systems have been developed for oral delivery of Naringin and Hesperidin to enhance its antioxidant and antidiabetic activities. The fabrication of Dual Loaded Flavono Nanoparticles by suitable method was optimized by Plackett Burman method. Optimization of the formulation requires proper designing of the experiments. For this reason, only in our current study, the placket burman method has been projected for the formulation of nanoparticles biodegradable polymers encompass bioflavonoid isolates for the antidiabetic activity. Ten critical parameters influencing the formulation has been selected and designed in Plackett Burman method of experimentation for 12 runs to assess independent variables influencing the result outcome. The results revealed that the 9th run shows the optimum particle size of 126.1 nm with zeta potential of 29.9 mV. Remarkably significant nanoparticles were obtained by exploiting the Plackett Burman method as designing tool. Loganathan and Sellappan, International Current Pharmaceutical Journal, January 2017, 6(2): 9-15 http://www.icpjonline.com/documents/Vol6Issue2/01.pdf","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"295 1","pages":"9-15"},"PeriodicalIF":0.0,"publicationDate":"2017-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79583620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Stable Angina Treatment Strategies and Current Practices in Lahore, Pakistan: A Cross-Sectional Analysis 巴基斯坦拉合尔稳定心绞痛治疗策略和当前实践:横断面分析

International Current Pharmaceutical Journal Pub Date : 2016-12-24 DOI: 10.3329/ICPJ.V6I1.30793

Ali Ahmed, M. Tanveer, N. Bano, G. Khan

{"title":"Stable Angina Treatment Strategies and Current Practices in Lahore, Pakistan: A Cross-Sectional Analysis","authors":"Ali Ahmed, M. Tanveer, N. Bano, G. Khan","doi":"10.3329/ICPJ.V6I1.30793","DOIUrl":"https://doi.org/10.3329/ICPJ.V6I1.30793","url":null,"abstract":"The purpose of the study was to analyze the prescription trends in the treatment of stable angina and to identify the therapeutic agents being prescribed majorly In Pakistan and to analyze that whether the current prescription patterns are in accordance with evidence based guidelines. A concurrent type of study was conducted from 24-01-2015 to 24-04-2015, through collection of data from prescriptions of patients suffering from stable angina in public sector hospitals of Lahore Pakistan. Data observations from the total 200 prescriptions collected from the hospitals of Lahore graphically demonstrate the trends of drug classes per prescription. The study identified that in the treatment of stable angina Antiplatelet are the most frequently prescribed drug class in Lahore and adjacent areas. Followed by CCBs on 2 nd rank and nitrates on 3 rd rank, ACE inhibitors and ARBs on 4 th number, after which statins occupy the 5 th position, lastly comes the position of beta blocker i.e. 6 th and diuretics are the least prescribed class. The anti-platelet blocker drugs were the most prescribed drug class in the management of chronic stable angina followed by calcium channel and vasodilators occupying the second and third rank respectively. The study also revealed that men are 1.5 times more vulnerable to the development of angina than the females. The study is also showing concrete evidence that there is strong need to follow guidelines for proper treatment. Ahmed et al., International Current Pharmaceutical Journal, December 2016, 6(1): 1-5 http://www.icpjonline.com/documents/Vol6Issue1/01.pdf","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"48 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2016-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85184307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Medication Safety in Hospital 医院用药安全

International Current Pharmaceutical Journal Pub Date : 2016-12-24 DOI: 10.3329/icpj.v6i1.30794

Ibrahim Alreshidi

引用次数: 1

Oral Films: A Comprehensive Review 口述电影:综合回顾

International Current Pharmaceutical Journal Pub Date : 2016-11-18 DOI: 10.3329/ICPJ.V5I12.30413

M. Mahboob, Tehseen Riaz, M. Jamshaid, I. Bashir, S. Zulfiqar

{"title":"Oral Films: A Comprehensive Review","authors":"M. Mahboob, Tehseen Riaz, M. Jamshaid, I. Bashir, S. Zulfiqar","doi":"10.3329/ICPJ.V5I12.30413","DOIUrl":"https://doi.org/10.3329/ICPJ.V5I12.30413","url":null,"abstract":"In the late 1970s, rapid disintegrating drug delivery system was developed as an alternative to capsules, tablets and syrups for geriatric and pediatric patients having problems in swallowing. To overcome the need, number of orally disintegrating tablets which disintegrate within one minute in mouth without chewing or drinking water were commercialized. Then later, oral drug delivery technology had been improved from conventional dosage form to modified release dosage form and developed recently rapid disintegrating films rather than oral disintegrating tablets. Oral disintegrating film or strips containing water dissolving polymer retain the dosage form to be quickly hydrated by saliva, adhere to mucosa, and disintegrate within a few seconds, dissolve and releases medication for oro-mucosal absorption when placed in mouth. Oral film technology is the alternative route with first pass metabolism. This review give a comprehensive detail of materials used in ODF, manufacturing process, evaluation tests and marketed products. Mahboob et al., International Current Pharmaceutical Journal, November 2016, 5(12): 111-117 http://www.icpjonline.com/documents/Vol5Issue12/03.pdf","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"31 1","pages":"111-117"},"PeriodicalIF":0.0,"publicationDate":"2016-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72659717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 45

Burn Cases, Their Management and Complications: A Review 烧伤病例，他们的处理和并发症:回顾

International Current Pharmaceutical Journal Pub Date : 2016-11-18 DOI: 10.3329/ICPJ.V5I12.30411

R. Masood, Zafeer Naeem Wain, Rehan Tariq, Muhammad Ullah, I. Bashir

引用次数: 9

Comparative Prevalence Studies of Hepatitis C Patients in Developing Vs Developed Countries 发展中国家与发达国家丙型肝炎患者患病率比较研究

International Current Pharmaceutical Journal Pub Date : 2016-11-18 DOI: 10.3329/ICPJ.V5I12.30412

Umer Tahir, Q. Ain, Rai Waqas, I. Bashir

{"title":"Comparative Prevalence Studies of Hepatitis C Patients in Developing Vs Developed Countries","authors":"Umer Tahir, Q. Ain, Rai Waqas, I. Bashir","doi":"10.3329/ICPJ.V5I12.30412","DOIUrl":"https://doi.org/10.3329/ICPJ.V5I12.30412","url":null,"abstract":"Viral hepatitis is one of the common transmissible causes of chronic liver responsible for increased risk of mortality and morbidity. Hepatitis C disease has worldwide high prevalence which is more fatal because of lack of vaccination availability. Present study was conducted with the aim of to address the comparative prevalence and risk factor of hepatitis C. Secondary objective was to evaluate the prevalence of this disease in Pakistan as compared to other countries. Most of the countries in the world do not have significant studies of population infected with Hepatitis C virus (HCV). During 1990-2016, 232 studies were included; containing 117 countries representing that 90% of the world population have 2.3% prevalence. According to studies, developed countries have low HCV prevalence while developing countries have high prevalence. Pakistan being a developing country has second highest HCV prevalence ranging from 4.5 to 8%. The reason of this high prevalence is unawareness about Hepatitis C in community and lack of successful therapies for patients with HCV. In past, developed countries had high prevalence but now they have low incidence because of proper system and awareness. Pakistan needs such kind of public awareness programs and better treatment facilities at affordable price to community. Tahir et al., International Current Pharmaceutical Journal, November 2016, 5(12): 106-110 http://www.icpjonline.com/documents/Vol5Issue12/02.pdf","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"13 1","pages":"106-110"},"PeriodicalIF":0.0,"publicationDate":"2016-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87332400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prescribing patterns: a key factor in rational use of drugs in Lahore, Pakistan 处方模式:巴基斯坦拉合尔合理用药的一个关键因素

International Current Pharmaceutical Journal Pub Date : 2016-11-18 DOI: 10.3329/icpj.v5i12.30414

A. Saleem, M. Farooq, Mufti Ali, Fahad Qureshi, A. Amin

{"title":"Prescribing patterns: a key factor in rational use of drugs in Lahore, Pakistan","authors":"A. Saleem, M. Farooq, Mufti Ali, Fahad Qureshi, A. Amin","doi":"10.3329/icpj.v5i12.30414","DOIUrl":"https://doi.org/10.3329/icpj.v5i12.30414","url":null,"abstract":"Prescribing pattern is the trending topic now days to promote rational use of drug and to make the drug therapy effective. Many factors like lack of knowledge, improper guidelines and personal interest affects the prescribing behaviour of a physician. To access the prescribing pattern and its relevant features which modulates it in the sector of Lahore, A survey was conducted in which physicians of different expertise were engaged from top hospitals of public and private sector. A questionnaire was designed and 100 physicians were interviewed as per structured questionnaire. The collected data was analysed by using analytical software SPSS 22. Pharmacological factors, cost effectiveness, efficacy of drug, recommended guidelines, psychological expectations and patient adherence are some factors which a prescriber keeps in his mind while prescribing a drug. Personal benefits and polypharmacy is strongly prohibited by physicians. physicians of Lahore prefer patient benefits upon their own in prescribing a drug but there are still some drawbacks like socio-economic factor and social culture which cause hindrance for a physician while prescribing. Saleem et al., International Current Pharmaceutical Journal, November 2016, 5(12): 118-119 http://www.icpjonline.com/documents/Vol5Issue12/04.pdf","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"67 1","pages":"118-119"},"PeriodicalIF":0.0,"publicationDate":"2016-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84046666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural remedies for diabetes mellitus 糖尿病的自然疗法

International Current Pharmaceutical Journal Pub Date : 2016-10-09 DOI: 10.3329/ICPJ.V5I11.29902

Rehan Tariq, Khalid Khan, R. Masood, Zafeer Naeem Wain

引用次数: 6

An overview of immunization practices in Pakistan 巴基斯坦免疫实践概况

International Current Pharmaceutical Journal Pub Date : 2016-10-09 DOI: 10.3329/ICPJ.V5I11.29901

Zafeer Naeem Wain, R. Masood, R. Ali, I. Bashir

{"title":"An overview of immunization practices in Pakistan","authors":"Zafeer Naeem Wain, R. Masood, R. Ali, I. Bashir","doi":"10.3329/ICPJ.V5I11.29901","DOIUrl":"https://doi.org/10.3329/ICPJ.V5I11.29901","url":null,"abstract":"Effective immunization practices are invariably a big challenge for Pakistan, facing many problems and barriers to immunize children against vaccine preventable diseases. Immunization coverage in Pakistan requires up-gradation. Barriers in attaining immunization goals are lack of Parent’s acceptance, lack of Parent’s awareness and knowledge about benefits of vaccination, socioeconomic inequity and lack of security for vaccinators. The problems of vaccine procurement are its transportation, storage and administration which also contribute to errors of immunization practices. In Pakistan Expanded Program on Immunization (EPI) with the support of WHO & UNICEF has a significant impact on overcoming these barriers. Expanded Program on Immunization (EPI) is facilitating through many vaccination centers, mobile vaccination sessions and public awareness campaigns, health visitors and EPI trained vaccinators to eradicate the barriers towards poor immunization practices in Pakistan. It is concluded from this study that it is the responsibility of Government and Health Professionals to find solutions to increases vaccination rate and coverage. It is the need of hour to find ways for creating awareness among parents and motivate them to follow complete vaccination schedule for the sake of better child health. Wain et al., International Current Pharmaceutical Journal, October 2016, 5(11): 94-96 http://www.icpjonline.com/documents/Vol5Issue11/01.pdf","PeriodicalId":13811,"journal":{"name":"International Current Pharmaceutical Journal","volume":"17 1","pages":"94-96"},"PeriodicalIF":0.0,"publicationDate":"2016-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81205590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8