International dental journal最新文献

{"title":"Substrate Stiffness Regulates the Osteogenesis of PDLSCs Via ERK-Mediated YAP Nuclear Translocation","authors":"Yuting Fu ,&nbsp;Yijie Wang ,&nbsp;Bo Cheng ,&nbsp;Rui Zou ,&nbsp;Wanting Wan","doi":"10.1016/j.identj.2025.103852","DOIUrl":"10.1016/j.identj.2025.103852","url":null,"abstract":"<div><h3>Objectives</h3><div>Periodontitis is an inflammatory disease and may lead to the progressive destruction of alveolar bone. Periodontal ligament stem cells (PDLSCs) exhibit significant regenerative potential, and their osteogenic differentiation is influenced by the biophysical microenvironment, particularly substrate stiffness. However, the mechanistic pathways through which stiffness modulates PDLSCs osteogenesis remain incompletely understood. This study aimed to elucidate the role of ERK1/2 and YAP signalling pathways in regulating PDLSCs osteogenic differentiation in response to substrate stiffness.</div></div><div><h3>Methods</h3><div>Gelatin methacryloyl (GelMA) hydrogels with varying stiffness were fabricated to culture PDLSCs. Cell viability, spreading, and osteogenic differentiation were evaluated through live/dead staining, immunofluorescence, qRT-PCR, Western blot analysis, and alizarin red staining. The involvement of ERK1/2 and YAP signalling pathways was investigated using specific inhibitors. An <em>in vivo</em> rat periodontitis model was developed to validate <em>in vitro</em> findings, with periodontal ligament stiffness and alveolar bone resorption assessed via nanoindentation and micro-computed tomography (micro-CT).</div></div><div><h3>Results</h3><div>PDLSCs cultured on stiffer substrates exhibited enhanced osteogenic differentiation, as evidenced by upregulated expression of osteogenic markers (RUNX2 and OCN) and increased mineralization. Stiff substrate promoted ERK1/2 phosphorylation and YAP nuclear translocation. Inhibition of ERK1/2 reduced YAP nuclear localization and suppressed osteogenic marker expression. <em>In vivo</em>, periodontitis-associated reductions in periodontal ligament stiffness correlated with decreased YAP nuclear translocation and significant alveolar bone resorption. YAP inhibition mirrored these effects, underscoring its critical role in osteogenesis.</div></div><div><h3>Conclusions</h3><div>Substrate stiffness regulates PDLSCs osteogenesis via ERK-mediated YAP nuclear translocation. These findings advance our understanding of the mechanotransduction mechanisms underlying PDLSCs differentiation and highlight potential therapeutic targets for periodontal regeneration.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 6","pages":"Article 103852"},"PeriodicalIF":3.7,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145266895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral–Systemic Health Burden and Dry Mouth as an Intermediary Factor: A Cross-Sectional Study in Singapore Nursing Homes","authors":"Sayaka Tada,&nbsp;Sarah Koh Mun Yee,&nbsp;Gabriel Lee Keng Yan,&nbsp;Tay Chong Meng,&nbsp;Sim Yu Fan,&nbsp;Clement Lai Wei Ming,&nbsp;Wong Mun Loke","doi":"10.1016/j.identj.2025.103934","DOIUrl":"10.1016/j.identj.2025.103934","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>This cross-sectional study aimed to assess the prevalence of oral and systemic health conditions among older adults in nursing homes (NHs) in Singapore and investigate associations between dry mouth and oral-systemic health factors.</div></div><div><h3>Methods</h3><div>Participants were selected through a stratified cluster sampling method across 8 NHs. Inclusion criteria included age ≥60 years and physical/cognitive ability to undergo oral screening. Data on systemic health (care dependence, malnutrition, multimorbidity, and polypharmacy) and oral health (dry mouth, oral hygiene, dentition, gingival and periodontal condition, and denture quality) were collected in 2024. Bivariate analyses (Mann-Whitney U test and chi-square test) were used to assess associations between dry mouth and other health parameters. Logistic regression models were conducted to examine independent associations with dry mouth. Statistical significance was set at <em>P</em> &lt; .05.</div></div><div><h3>Results</h3><div>A total of 173 NH residents completed oral assessments (mean age: 75.0 ± 9.1 years; 38% female). Systemic health concerns were prevalent: 75.7% were care-dependent, 80.9% were malnourished or at risk, and 84.1% had multimorbidity. Cardio-cerebrovascular diseases (CVD) were the most common disease category (76.4%). Oral health problems were also widespread: 63.6% showed clinical symptoms of dry mouth, 46.6% had poor oral hygiene, 50.8% had at least one untreated coronal and/or root caries, and 89.2% showed gingival inflammation. Multivariate analysis identified CVD (OR = 3.99) as a systemic factor significantly associated with dry mouth. Greater plaque accumulation (OR = 5.09) and root caries (OR = 1.93) were also independently associated with dry mouth.</div></div><div><h3>Conclusions</h3><div>This study provides the first comprehensive report on oral-systemic health burden in NH residents in Singapore. Dry mouth emerged as a potential intermediary factor linking systemic health conditions and dental deterioration. These findings underscore the importance of interprofessional care strategies to address dry mouth and its consequences in this vulnerable population. (292 words)</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 6","pages":"Article 103934"},"PeriodicalIF":3.7,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145266280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy in Diagnosing Periodontitis Using the AAP/EFP 2017 Classification","authors":"Hammam I. Fageeh ,&nbsp;Hytham N. Fageeh ,&nbsp;Wael I. Ibraheem ,&nbsp;Ashok Kumar Bhati ,&nbsp;Bashair Mohammed Wasli ,&nbsp;Hind Ali Abeery ,&nbsp;Elham Ali Tohari ,&nbsp;Lujain K. Mokli ,&nbsp;Shreefah M. Faris","doi":"10.1016/j.identj.2025.103907","DOIUrl":"10.1016/j.identj.2025.103907","url":null,"abstract":"<div><h3>Purpose</h3><div>In the 2017 periodontal classification, periodontitis was diagnosed based on stage, grade and extent. Periodontitis is diagnosed not only by periodontists but also by general dentists. Therefore, the study was conducted to determine and compare the accuracy of periodontists, postgraduate periodontal students, general dentists and undergraduate students in diagnosing the stage, grade, and extent of periodontitis.</div></div><div><h3>Method</h3><div>Four groups of examiners—periodontists, postgraduate periodontal students, general dentists, and undergraduate students (<em>n</em> = 10 each) were included in the study. Five documented periodontitis cases were sent to examiners to determine the stage, grade, and extent of periodontitis. Average score (for stage, grade and extent separately) and overall score (combined score of stage, grade, and extent) were obtained. Intergroup comparisons for staging, extent, and grade were performed using a one-way ANOVA. The correlation between different scores obtained by groups of examiners was assessed using the intraclass correlation coefficient (ICC). <em>P</em> &lt; .05 was considered statistically significant.</div></div><div><h3>Results</h3><div>Substantial agreement was observed for stage (ICC = 0.658) and overall score (ICC = 0.690). Agreement for grade and extent was moderate (ICC = 0.518) and fair (ICC = 0.273), respectively. Significant substantial agreement between periodontists and postgraduates with the assessment of stage (ICC = 0.756) and overall score (ICC = 0.698) was found. For the overall score, periodontists (mean 1.74 ± 0.34) and postgraduates (mean 1.48 ± 0.391) performed better. Undergraduate students (mean 1.42 ± 0.25) performed better than general dentists (mean 1.40 ± 0.45).</div></div><div><h3>Conclusion</h3><div>Periodontists performed better than postgraduate students, undergraduates and general dentists. Undergraduates performed better than general dentists.</div></div><div><h3>Clinical relevance</h3><div>Correct diagnosis is critical for providing the correct treatment plan for treating the disease. Education and training can result in accurate diagnosis of the stage, grade, and extent of periodontitis, thereby providing treatment accordingly.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 6","pages":"Article 103907"},"PeriodicalIF":3.7,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145266285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Electrospun Heparin Modified Nanofiber Membrane Carrying Multiple Growth Factors for Dental Pulp Regeneration","authors":"Xin-Lu Li,&nbsp;Hui Liu,&nbsp;Wei Fan,&nbsp;Bing Fan","doi":"10.1016/j.identj.2025.103919","DOIUrl":"10.1016/j.identj.2025.103919","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>To develop a multifunctional nanofiber membrane carrying angiogenic, dentinogenic, and neurogenic growth factors for dental pulp regeneration.</div></div><div><h3>Methods</h3><div>Electrospun gelatin/polycaprolactone (GEL/PCL) nanofiber membranes were modified with heparin (H-GEL/PCL) and loaded with VEGF, BMP-2, and NGF. The physicochemical properties and growth factor release behaviour of the membranes were systematically characterized. Their bioactivity was evaluated by assessing cell viability, proliferation, migration, and differentiation of human dental pulp stem cells in vitro, and a subcutaneous semiorthotopic transplantation model was established to verify the pulp-like tissue regeneration potential in vivo.</div></div><div><h3>Results</h3><div>The H-GEL/PCL membranes exhibited uniform nanofiber morphology, favourable mechanical and hydrophilic properties, sustained degradation, and controlled growth factor release. H-GEL/PCL membranes loaded with VEGF, BMP-2, and NGF enhanced angiogenic, odontogenic, and neurogenic differentiation of dental pulp stem cells in vitro and facilitated vascular and neural ingrowth of dental pulp-like tissue in vivo.</div></div><div><h3>Conclusions</h3><div>The H-GEL/PCL membrane carrying angiogenic, dentinogenic, and neurogenic growth factors effectively promotes angiogenesis and neurogenesis in the regenerated dental pulp-like tissue.</div></div><div><h3>Clinical relevance</h3><div>This multifunctional membrane offers a promising strategy for regenerating vascularized and innervated dental pulp-like tissues, with potential application for regenerative endodontic therapy.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 6","pages":"Article 103919"},"PeriodicalIF":3.7,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145266896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Global Perspective on the Burden of Caries in Permanent Teeth in China (1990-2021): A Population-Based Analysis","authors":"Yuyang Wang ,&nbsp;Lu Fan ,&nbsp;Yueyuan Yu","doi":"10.1016/j.identj.2025.103887","DOIUrl":"10.1016/j.identj.2025.103887","url":null,"abstract":"<div><h3>Objectives</h3><div>The aim of this study was to assess trends in the burden of caries in permanent teeth in China over the past 32 years and compare them with G20 countries, and project future trends up to 2036.</div></div><div><h3>Method</h3><div>Data were obtained from the Global Burden of Disease (GBD) 2021 study. We describe temporal trends in age-standardised incidence, prevalence, and disability-adjusted life years (DALYs) of caries in permanent teeth in China, the Group of Twenty (G20), and globally. Disease burden status was analysed using a combination of age-period-cohort modeling, Joinpoint regression analysis, decomposition analysis, and health inequality analysis. Finally, Bayesian age-period-cohort (BAPC) modeling was applied to predict the burden of permanent dental caries in China by 2036.</div></div><div><h3>Results</h3><div>In 2021, the ASIR, ASPR, and age-standardised DALYs for caries in permanent teeth in China were 19,634.62 cases per 100,000 (95% CI: 16,565.80-23,954.90), 23,759.62 cases per 100,000 (95% CI: 20,403.06-27,675.83), and 19.43 per 100,000 (95% CI: 8.64-37.07), respectively. ASIR and ASPR have declined since 2015. Age-period-cohort analysis identified peak ASIR and ASPR in the 20 to 24 age group. Decomposition analysis indicated that epidemiologic changes and aging drove increased ASIR, while population growth influenced ASPR and age-standardised DALYs. Health inequality analyses showed reduced SDI-related inequality, with a burden concentrated in high SDI countries. A decreasing trend in ASIR and ASPR in China is projected from 2022 to 2036.</div></div><div><h3>Conclusion</h3><div>The study reveals the status of the burden of caries in permanent teeth in China and the gap with other countries.</div></div><div><h3>Clinical significance</h3><div>The burden of permanent dental caries in China is influenced by population aging, growth, and epidemiological shifts. A mismatch between public health systems and economic development necessitates targeted prevention strategies for key populations to reduce health disparities.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 6","pages":"Article 103887"},"PeriodicalIF":3.7,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145266282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated LL-37/FPR2 Axis and its Regulatory Role for Gingival Fibroblasts in Periodontitis","authors":"Tingting Lin ,&nbsp;Zhurong Cui ,&nbsp;Yue Shen,&nbsp;Ruhan Yang,&nbsp;Weijun Yu,&nbsp;Shucheng Hu,&nbsp;Yuanjie Shi,&nbsp;Bin Jiang,&nbsp;Min Jin,&nbsp;Eryi Lu,&nbsp;Yuting Gu","doi":"10.1016/j.identj.2025.103943","DOIUrl":"10.1016/j.identj.2025.103943","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>LL-37, an antimicrobial peptide with dual pro-/anti-inflammatory roles, has been implicated in the pathogenesis of periodontitis, yet its specific action through its receptor Formyl peptide receptor 2 (FPR2) remains unclear. This study aimed to elucidate the expression profile of the LL-37/FPR2 axis in periodontitis and its regulatory effects on gingival fibroblasts (GFs).</div></div><div><h3>Methods</h3><div>Fifty-seven periodontitis patients and fifty-seven healthy controls were included to assess the levels of LL-37 and FPR2 in gingival tissues, gingival crevicular fluid and GFs, as well as to assess their correlation with disease progression. Primary human GFs were isolated and subsequently stimulated with <em>Porphyromonas gingivalis</em> lipopolysaccharide alongside varying concentrations of LL-37. To elucidate the functional role of FPR2 in this system, targeted gene silencing was performed using small interfering RNA.</div></div><div><h3>Results</h3><div>Both LL-37 and FPR2 were upregulated in gingival tissues or gingival crevicular fluid from periodontitis patients, showing a significant positive correlation. FPR2 expression increased in GFs under periodontal inflammatory conditions, and high concentration of LL-37 exacerbated pro-inflammatory response in GFs via FPR2. Clinically, elevated LL-37 and FPR2 correlated with disease severity, particularly in patients with higher LL-37 expression. Patients with co-upregulation of both LL-37 and FPR2 exhibited more severe periodontitis.</div></div><div><h3>Conclusions</h3><div>The LL-37/FPR2 axis was co-upregulated in periodontitis-affected gingival tissues and correlated with disease severity. The LL-37/FPR2 axis exacerbated pro-inflammatory response in GFs under periodontal inflammatory conditions, suggesting its potential as a therapeutic target for mitigating periodontal inflammation.</div></div><div><h3>Clinical Relevance</h3><div>We found that the co-upregulation of LL-37/FPR2 in periodontitis-affected gingival tissues, positively correlates with clinical parameters (PD/CAL). These findings provide new insights into the dual role of LL-37 in periodontal inflammation and suggest novel strategies for targeted therapy by selectively inhibiting high-concentration LL-37/FPR2 signaling.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 6","pages":"Article 103943"},"PeriodicalIF":3.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145266894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Glucose Microenvironment Accelerates Malignant Progression Via O-GlcNAcylation in Oral Squamous Cell Carcinoma","authors":"Zhuang Zhu ,&nbsp;Wenhao Ren ,&nbsp;Xiaohan Yan ,&nbsp;Shaoming Li ,&nbsp;Jingjing Zheng ,&nbsp;Keqian Zhi ,&nbsp;Ling Gao","doi":"10.1016/j.identj.2025.103897","DOIUrl":"10.1016/j.identj.2025.103897","url":null,"abstract":"<div><h3>Background</h3><div>Diabetes mellitus (DM) is a risk factor for oral squamous cell carcinoma (OSCC). O-GlcNAcylation is a specific form of glycosylation modification sensitive to glucose levels and implicated in tumour progression. However, the association between the high-glucose environment, O-GlcNAcylation, and OSCC needs further exploration.</div></div><div><h3>Methods</h3><div>The relationship between DM status and clinicopathological factors was analysed. The Kaplan–Meier analysis was performed to evaluate the effect of DM on OSCC prognosis. The proliferation, migration, invasion, and apoptosis of OSCC cell lines (SCC25 and CAL27) in the high-glucose microenvironment were analysed using CCK8, colony formation, wound healing, transwell assays, flow cytometry, and western blots (WB). Immunohistochemical staining and WB were used to detect O-GlcNAc transferase (OGT) and O-GlcNAcylation levels in OSCC tissues and cells. Changes in cell proliferation, migration, invasion, and apoptosis were analysed in OSCC cells after OGT-shRNA knockdown or adding the OGT inhibitor OSMI-1. The effect of O-GlcNAcylation on the expression of phosphorylated proteins of the PI3K/AKT/mammalian target of rapamycin signalling pathway was analysed by WB.</div></div><div><h3>Results</h3><div>DM status was associated with the clinical T stage, lymph node metastasis, Ki-67, and depth of invasion in OSCC. DM status was significantly associated with prognosis in patients with OSCC. In vitro experiments showed that the high-glucose microenvironment promoted the malignant progression of OSCC cells. OSCC tissues from patients with DM and OSCC cells cultured in high-glucose medium exhibited high O-GlcNAcylation levels. Decreases in hyper-O-GlcNAcylation by knocking down or inhibiting OGT inhibited proliferation and metastasis and promoted the apoptosis of OSCC cells in a high-glucose environment. The hyper-O-GlcNAcylation-mediated protumoural properties partially depended on the PI3K/AKT/mammalian target of rapamycin pathway.</div></div><div><h3>Conclusions</h3><div>The findings highlight the elevated expression of O-GlcNAcylation in OSCC in a high-glucose microenvironment and its involvement in tumour malignant progression. The study findings have significant implications for the treatment of patients with OSCC who also have DM.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 6","pages":"Article 103897"},"PeriodicalIF":3.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Head and Neck Cancer Incidence, Mortality, and Disability-Adjusted Life Years From 1990 to 2021-A Systematic Analysis for the Global Burden of Disease Study","authors":"Yue Wang ,&nbsp;Jingjing Zheng ,&nbsp;Wenhao Ren ,&nbsp;Shaoming Li ,&nbsp;Keqian Zhi ,&nbsp;Ling Gao","doi":"10.1016/j.identj.2025.103947","DOIUrl":"10.1016/j.identj.2025.103947","url":null,"abstract":"<div><h3>Objective</h3><div>This study evaluates the global burden of head and neck cancers, analyzing incidence, mortality, and DALYs from 1990 to 2021, across age groups and regions with varying SDI levels.</div></div><div><h3>Materials and Methods</h3><div>Data from the Global Burden of Disease (GBD) database (1990-2021) was utilized to examine incidence, mortality, and DALYs for head and neck cancers. Regional disease trends were analyzed using age-standardized rates (ASR), estimated annual percentage change (EAPC), Joinpoint regression, and the Age-Period-Cohort model. A global map depicted disease burden across 204 countries and territories, 21 GBD regions, and 5 SDI regions.</div></div><div><h3>Results</h3><div>In 2021, there were 421,577 new lip and oral cavity cancer cases and 208,379 deaths, with DALYs totaling 5,874,070 years. EAPC results indicated rising incidence for lip and oral cavity cancers (EAPC: 0.4% [95% CI: 0.33-0.46]) and other pharyngeal cancers (EAPC: 0.68% [95% CI: 0.6-0.75]). The AAPC model showed an overall increase in incidence for lip and oral cavity cancers (AAPC: 0.442 [0.374-0.511]) and other pharyngeal cancers (AAPC: 0.716 [0.607-0.826]). While mortality rates remained stable or declined. Lip and oral cavity cancer incidence rose most in the middle SDI region, followed by low-middle and low SDI regions, while other pharyngeal cancers saw the highest increase in high, low-middle, and low SDI regions. The AAPC model indicated a declining incidence for lip and oral cavity cancers in all regions except the high SDI region (AAPC: -0.012 [-0.17-0.147]), where other pharyngeal cancers had the highest increase (AAPC: 1.034 [0.741-1.329]). Mortality for lip and oral cavity cancers rose in low-middle SDI regions, while other pharyngeal cancers showed increased mortality in low-middle and low SDI regions. South Asia reported the highest incidence, mortality, and DALYs for lip, oral cavity, and oropharyngeal cancers in 2021. Age-cohort analysis showed that incidence rose until age 55, stabilizing or declining afterward, while the burden of lip and oral cavity cancers increased after 55, with mortality highest over 80.</div></div><div><h3>Conclusion</h3><div>Head and neck cancer burden is concentrated in low- and middle-income countries, highlighting the need for prevention, early screening, risk factor control, and improved data monitoring in low-income regions.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 6","pages":"Article 103947"},"PeriodicalIF":3.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Mediterranean Diet Adherence and Periodontal Health Among Junior High School Students in China","authors":"Ying Ying ,&nbsp;Lujin Zhang ,&nbsp;Huan Zhou ,&nbsp;Ruyu Sun ,&nbsp;Jiadan Dai ,&nbsp;Weifang Zhang","doi":"10.1016/j.identj.2025.103922","DOIUrl":"10.1016/j.identj.2025.103922","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to explore the association between Mediterranean diet adherence and periodontal health among junior high school students in China.</div></div><div><h3>Materials and Methods</h3><div>A cross-sectional study was carried out in Zhejiang Province from March to June 2023. Through multistage stratified sampling, 1,462 eighth-grade students (aged 13-16 years) were recruited. Periodontal health was evaluated by clinical examinations, with participants classified into good and poor periodontal status groups. Mediterranean diet adherence was measured using the 16-item KIDMED questionnaire. Sociodemographic and behavioral covariates were also collected. Chi-square tests were used for univariate analyses, and a multivariable logistic regression model was applied to estimate the associations.</div></div><div><h3>Results</h3><div>A total of 18.42% (269/1,462) of the students had a poor periodontal status. Univariate analyses showed that only 1 child status, parental education, occupation, family income, brushing frequency, and Mediterranean diet adherence were significantly associated with periodontal health. In the multivariable logistic regression, only children had 1.75-fold increased odds of poor periodontal status (aOR = 1.75, 95% CI: 1.26-2.44, <em>P &lt; .</em>001), and low Mediterranean diet adherence independently increased the odds of poor periodontal health by 72% compared to high adherence (aOR = 1.72, 95% CI: 1.04-2.86, <em>P &lt; .</em>05).</div></div><div><h3>Conclusion</h3><div>Non-only child status and low Mediterranean diet adherence are independent risk factors for poor periodontal health among Chinese junior high school students. Family-centered interventions that focus on improving dietary quality and resource allocation in multi-child families are needed.</div></div><div><h3>Clinical Relevance</h3><div>This study highlights the translational importance of integrating dietary assessment into routine adolescent dental care. Promoting Mediterranean-style dietary habits and supporting oral health in multi-child families could help reduce the risk of periodontal disease during a critical developmental stage.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 6","pages":"Article 103922"},"PeriodicalIF":3.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI Acceptability in Dentistry: Insights from Dental Professionals and Students in the Netherlands: A Pilot Study","authors":"Ru-shan Goey ,&nbsp;Leslie Elenbaas ,&nbsp;Erwin Berkhout ,&nbsp;David Anssari Moin ,&nbsp;Rianne van der Kleij ,&nbsp;Tymour Forouzanfar ,&nbsp;Niels H. Chavannes ,&nbsp;María Villalobos-Quesada","doi":"10.1016/j.identj.2025.103933","DOIUrl":"10.1016/j.identj.2025.103933","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>There is an increasing worldwide interest and investment in the application of Artificial Intelligence (AI), and the dental field is no exception. AI shows promise in all dental disciplines. However, uptake in clinical practice is slow, and there is limited understanding of users’ acceptability in the Netherlands. This study aims to provide insights into the acceptability of Dutch dental professionals and students regarding AI in the dental field.</div></div><div><h3>Methods</h3><div>This cross-sectional, observational study was conducted using an anonymous online questionnaire (Qualtrics). Participants included dental students, dentists, and maxillofacial surgeons in the Netherlands. Data collection took place between April and May 2023, and data were analyzed using descriptive statistics.</div></div><div><h3>Results</h3><div>The survey was completed by 166 participants: 61% were dentists, 34% dental students, and 5% maxillofacial surgeons. Overall, respondents were positive about working with AI, regarding it as an opportunity to, for example, save time and improve care in all dental fields. They did not perceive AI as threatening, but as a useful support tool. The tasks for which AI was regarded most useful were: detection of pathologies in the jaws, evaluation of treatment success, planning jaw surgery, detection of caries, endodontic abnormalities, periodontal abnormalities, and 3D implant planning and positioning. AI education was deemed necessary at dental/medical school, postgraduate levels, and conferences.</div></div><div><h3>Conclusion and clinical relevance</h3><div>This study contributes to filling the literature gap regarding AI acceptability in the dental field and provides evidence to justify the structural incorporation of AI education. It is necessary to prepare current and future dental professionals to work with AI, and to play an active role in the co-development, implementation, and sustained adoption of this technology. Only such an integrated strategy will allow us to generate AI that will positively transform clinical practice.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 6","pages":"Article 103933"},"PeriodicalIF":3.7,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}