International dental journal最新文献

{"title":"Glycolytic Reprogramming in Oral Squamous Cell Carcinoma: Molecular Regulators and Natural Product-Based Therapies","authors":"Ji-Ae Shin","doi":"10.1016/j.identj.2025.103949","DOIUrl":"10.1016/j.identj.2025.103949","url":null,"abstract":"<div><div>Oral squamous cell carcinoma (OSCC), the most common malignancy of the oral cavity, poses significant clinical challenges owing to late-stage diagnosis, frequent recurrence, and therapy resistance. Metabolic reprogramming, particularly the upregulation of aerobic glycolysis, is intricately associated with tumor progression, metastasis, and therapeutic failure. This metabolic alteration not only favors rapid cancer cell proliferation and promotes immune evasion but also results in the formation of a supportive tumor microenvironment (TME). This review synthesizes the current knowledge on the molecular regulators of glycolytic reprogramming in OSCC and elucidates their underlying mechanisms. We also delineated the glycolytic landscape of the OSCC tumor microenvironment, which encompasses cancer-associated fibroblasts (CAFs), CD4⁺ and CD8⁺ T cells, and tumor-associated macrophages (TAMs). Furthermore, we underscore the therapeutic potential of natural product-based strategies that target aerobic glycolysis in OSCC. A deeper understanding of these metabolic pathways may aid in the development of metabolism-targeted interventions for OSCC. This review also offers insights into how targeting glycolytic reprogramming, particularly with natural products, may enhance the efficacy of current chemotherapeutic and immunotherapeutic strategies for OSCC by overcoming resistance and reprogramming the TME.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 6","pages":"Article 103949"},"PeriodicalIF":3.7,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Drugs Associated With Oral Ulcers Based on Pharmacovigilance","authors":"Xinyue Zhang ,&nbsp;Xueqing Li ,&nbsp;Wuda Huoshen ,&nbsp;Shiting Li","doi":"10.1016/j.identj.2025.103957","DOIUrl":"10.1016/j.identj.2025.103957","url":null,"abstract":"<div><h3>Background</h3><div>Oral ulcers are common, painful lesions that significantly affect quality of life. Certain medications, especially antimetabolites and mTOR inhibitors, have been implicated in their development. However, drug-induced oral ulcers have not been systematically evaluated using large-scale real-world data.</div></div><div><h3>Methods</h3><div>The study employed a dual-validation strategy combining pharmacovigilance signal mining and multivariate logistic regression analysis. By querying specific ‘preferred terms’ (PTs), adverse event reports in the FAERS database of the Food and Drugs Adminstration of USA, related to oral ulcers were identified. Signal detection was conducted using four disproportionality analysis methods. For the initially screened candidate drugs, a multivariate logistic regression model was constructed, adjusting for potential confounders such as age, gender, weight, reporter type, reporting country and year, to further validate their independent association with oral ulcer reports (<em>P</em>_FDR &lt; .05).</div></div><div><h3>Results</h3><div>Reports of oral ulcerations have shown a significant and sustained increase since 2010, peaking in 2020. The multi-method validation framework identified 289 statistically significant drug-oral ulceration association signals. Drugs with the highest signal strength included cyclizine, mycophenolate sodium and aredia. Other drugs with significant signals included lactulose, acetaminophen codeine phosphate, leflunomide, omalizumab, everolimus and atezolizumab. Integrating signal detection results, logistic regression analysis further confirmed that multiple drugs were significantly associated with the risk of oral ulcer reports. Drugs with extremely high odds ratios (ORs) included estriol and docetaxel sagent. Strongly associated drugs also included immunosuppressants, antihistamines, combination analgesics, bisphosphonates, sartans and antibiotics.</div></div><div><h3>Conclusion</h3><div>This study systematically identified approximately 289 drugs significantly associated with oral ulcer risk, including immunosuppressants, cardiovascular drugs and bronchodilators. Based on pharmacovigilance signal detection and regression analysis, patients on long-term treatment with these drugs should receive enhanced oral monitoring. As this is an observational study, further prospective and experimental research is needed to confirm causality.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 6","pages":"Article 103957"},"PeriodicalIF":3.7,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TTK Defines a High-Risk Oral Squamous Cell Carcinoma Subtype Through Dual mTORC1/NF-κB Activation","authors":"Huan Jin ,&nbsp;Tianjie Liu ,&nbsp;Yucheng Guo ,&nbsp;Wenqing Bu ,&nbsp;Fei Liu ,&nbsp;Yuxia Hou","doi":"10.1016/j.identj.2025.103945","DOIUrl":"10.1016/j.identj.2025.103945","url":null,"abstract":"<div><h3>Objective</h3><div>Oral squamous cell carcinoma remains difficult to treat because of its marked tumor heterogeneity, highlighting the need to identify molecular subtypes with distinct therapeutic vulnerabilities. This study aimed to comprehensively characterize OSCC molecular subtypes and identify potential therapeutic targets.</div></div><div><h3>Materials and methods</h3><div>We conducted an integrated analysis combining single-cell and bulk RNA sequencing from 709 OSCC cases. Protein interactions were examined using mass spectrometry and immunoprecipitation assays. The functional roles of key regulators were evaluated through in vitro cell proliferation and invasion assays, RNA sequencing of knockdown cell lines, and in vivo xenograft models. Statistical analyses included differential gene expression analysis, pathway enrichment, and IC50 determination for drug sensitivity.</div></div><div><h3>Results</h3><div>We identified a distinct molecular OSCC subtype marked by concurrent activation of the mTORC1 and NF-κB pathways, with TTK emerging as a central regulator of this co-activation. Patients in this subtype exhibited pronounced genomic instability, reflected by increased tumor mutational burden, higher TP53 mutation frequency, copy number amplifications across multiple genomic regions. Mechanistically, mass spectrometry and co-immunoprecipitation assays showed that TTK directly interacts with the TAK1–TAB protein complex, thereby activating the NF-κB pathway. RNA sequencing of TTK knockdown cell lines demonstrated significant downregulation of both mTOR and NF-κB signaling upon TTK suppression. Functional assays confirmed that TTK inhibition strongly reduced OSCC cell proliferation and invasion and markedly enhanced cisplatin sensitivity in vitro and in vivo.</div></div><div><h3>Conclusion</h3><div>Our findings establish TTK as a pivotal mediator defining a high-risk OSCC molecular subtype characterized by simultaneous activation of the mTORC1 and NF-κB pathways and severe genomic instability. The discovery of a direct interaction between TTK and the TAK1–TAB complex provides novel mechanistic insight into NF-κB activation, while its inhibition significantly improves cisplatin sensitivity. These results warrant further clinical evaluation of TTK inhibitors as a promising therapeutic strategy to improve outcomes in aggressive OSCC.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 6","pages":"Article 103945"},"PeriodicalIF":3.7,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145299993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Data Drift in Dental AI","authors":"Priyanka Gudsoorkar","doi":"10.1016/j.identj.2025.103937","DOIUrl":"10.1016/j.identj.2025.103937","url":null,"abstract":"","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 6","pages":"Article 103937"},"PeriodicalIF":3.7,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of Biocompatibility between Conventional and Computer-Aided Design/Computer-Aided Manufacturing Dental Polymers Using a Golden Hamster Model","authors":"Xia Wei ,&nbsp;Huakun Shangguan ,&nbsp;Ling Wu ,&nbsp;Linjuan Gao ,&nbsp;Yu Pan ,&nbsp;Yiling Cheng ,&nbsp;Hui Cheng ,&nbsp;Yinghui Wang","doi":"10.1016/j.identj.2025.103958","DOIUrl":"10.1016/j.identj.2025.103958","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>Computer-aided design/computer-aided manufacturing (CAD/CAM) dental polymers exhibit superior mechanical properties compared to conventional ones, but their biocompatibility remains controversial. This study aimed to systematically compare <em>in vivo</em> biocompatibility of conventional and CAD/CAM dental polymers using a golden hamster model.</div></div><div><h3>Methods</h3><div>Six dental polymers were evaluated: conventional (VAR) and CAD/CAM (OP) polymethylmethacrylate (PMMA) denture base materials; conventional bis-acrylic (PT) and CAD/CAM PMMA (DM) interim restorative materials; pressed (PB) and CAD/CAM (CB) polyetheretherketone (PEEK) prosthetic framework materials, with polypropylene as control. Disk specimens (<em>n =</em> 6) were sutured in golden hamster buccal pouches for 14- and 28-day mucosal irritation tests. Systemic and local biocompatibility was assessed through hepatic/renal function tests, histopathology (HE staining), apoptosis detection (TUNEL), and apoptosis-related molecular analysis (RT-qPCR and Western blot) of buccal pouch mucosa, liver, and kidney tissues.</div></div><div><h3>Results</h3><div>All groups showed normal physiological conditions throughout the study period. Histological examination revealed normal tissue morphology in all tested organs, with only mild or no mucosal irritation observed. Transient fluctuations were observed in ALB, A/G, BUN and TP at 14 days, but the differences between groups tended to stabilize at 28 days. The results of TUNEL and RT-qPCR demonstrated comparable results across all groups. The expression of Bax and Bcl-2 proteins in buccal pouch mucosa of VAR group were elevated at 28 days compared to 14 days, while only Bax protein was elevated in PB group (<em>P</em> &lt; .05). The expression level of pro Caspase-3 protein in the liver tissue of VAR group and PT group decreased at 28 days (<em>P</em> &lt; .05).</div></div><div><h3>Conclusions</h3><div>Both conventional and CAD/CAM dental polymers exhibited acceptable <em>in vivo</em> biocompatibility, but CAD/CAM dental polymers showed superior temporal stability.</div></div><div><h3>Clinical Relevance</h3><div>The superior temporal stability in the <em>in vivo</em> biocompatibility profile of CAD/CAM dental polymers supports their clinical preference for long-term prosthodontic applications.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 6","pages":"Article 103958"},"PeriodicalIF":3.7,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibroblast Ferroptosis Aggravates Inflammation Response in Dental Pulpitis","authors":"Xiaohui Lv ,&nbsp;Xuan Chen ,&nbsp;Li Lin,&nbsp;Yang Li,&nbsp;Liecong Lin,&nbsp;Bingtao Wang,&nbsp;Xiaoshi Chen,&nbsp;Qianzhou Jiang","doi":"10.1016/j.identj.2025.103927","DOIUrl":"10.1016/j.identj.2025.103927","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>Pulpitis, an inflammatory disorder of dental pulp tissue, represents a common clinical challenge in endodontic pathology. Emerging evidence implicates ferroptosis, a newly recognised iron-dependent form of regulated cell death, in the pathogenesis of inflammatory conditions. However, its functional significance in pulpal inflammation remains poorly characterised. The objectives of this study were to (1) investigate the functional significance of ferroptosis in pulpitis; (2) identify the cell type undergoing ferroptosis; and (3) provide novel insights into therapeutic strategies.</div></div><div><h3>Methods</h3><div>We conducted an investigation combining clinical specimen analysis (human pulp tissues), single-cell transcriptomic profiling and experimental mice models. Co-localisation staining and single-cell RNA sequencing data were analysed to identify the cell type that underwent ferroptosis. Immunofluorescence co-localisation studies and scRNA-seq data analysis were used to identify cellular populations undergoing ferroptosis. The susceptibility of dental pulp fibroblasts to ferroptosis in an inflammatory condition was investigated using <em>in vitro</em> cell cultures.</div></div><div><h3>Results</h3><div>Our findings demonstrate that dental pulp fibroblasts undergo ferroptosis in pulpitis. Pulpitis-induced pro-inflammatory immune responses were characterised by a profound elevation of fibroblast-derived interleukin-6 <em>(</em>IL-6) and interleukin-1β (IL-1β), which was attenuated by ferroptosis inhibition. Pulp inflammation is alleviated by inhibition of fibroblast ferroptosis.</div></div><div><h3>Conclusion</h3><div>This study reveals a previously unrecognised mechanistic link between fibroblast ferroptosis and pulpal immunopathology, providing novel insights into therapeutic strategies for vital pulp preservation.</div></div><div><h3>Clinical Significance</h3><div>The identification of fibroblast ferroptosis as a driver of pulp inflammation and inhibition of inflammation by ferroptosis inhibitors Ferrostatin-1 (Fer-1) in mice models offer potential alternative therapeutic strategies for vital pulp preservation.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 6","pages":"Article 103927"},"PeriodicalIF":3.7,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145266283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Auxiliary Devices on the Accuracy of Complete‑Arch Implant Digital Impressions: An in Vitro Study","authors":"Hao Liu ,&nbsp;Xiangting Zhang ,&nbsp;Ya Gao ,&nbsp;Mengyao Li ,&nbsp;Zhe Qu ,&nbsp;Jiaming Zhao","doi":"10.1016/j.identj.2025.103950","DOIUrl":"10.1016/j.identj.2025.103950","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the effectiveness of the auxiliary device in acquiring implant and soft tissue data using intraoral scanning and its influence on the accuracy of digital impressions for edentulous implants.</div></div><div><h3>Methods</h3><div>Three standardized implant models for edentulism, categorized as 2-4, 2-5 and 2-4-6, were designed and printed based on the distribution of implants. Various auxiliary devices were designed for each model, and an artificial gingiva with cube-like marking points was created to test the completeness of soft tissue information capture. The models were scanned using an extraoral model scanner to obtain accurate baseline data. Intraoral scans (Trios 4) were performed before and after adding auxiliary devices. The scan data were evaluated using inspection software. The linear distances of center point of upper plane between scan body was calculated. The Shapiro–Wilk normality test, independent-samples t test, and Mann–Whitney nonparametric test were used for statistical analysis. Statistical significance was set at α = 0.05.</div></div><div><h3>Results</h3><div>The trueness and precision of most loci improved with the inclusion of auxiliary devices, surpassing their counterparts without such devices. Notably, trueness advanced in: the 2-4 group using 2.5-mm-wide smooth-surface (W2.5-S) for the longest span (#14-#24) [decreased from (0.123 ± 0.034) mm to (0.081 ± 0.033) mm]; the 2-5 group employing 2.5-mm-wide cube-like (W2.5-C) and hemisphere-like(W2.5-H) devices for the longest span (#15-#25), (decreased from [0.155 ± 0.061] mm to [0.028 ± 0.017] mm and [0.035 ± 0.019] mm); and the 2-4-6 group with W2.5-C and W2.5-H devices for loci #16-#24 [decreased from (0.091 ± 0.056) mm to (0.055 ± 0.033 mm and (0.054 ± 0.041) mm] and #16-#26 (decreased from [0.148 ± 0.112] mm to [0.088 ± 0.041] mm and [0.084 ± 0.047] mm) (<em>P &lt; .</em>05). Adding the devices did not affect the root-mean-square values of the soft tissue marker points.</div></div><div><h3>Conclusions</h3><div>The use of auxiliary devices enhances the accuracy of digital impressions for edentulous implant restorations obtained using intraoral scanners while also capturing complete soft tissue information.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 6","pages":"Article 103950"},"PeriodicalIF":3.7,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145266284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Health-Related Quality of Life among Asylum Seekers and Refugees: A Systematic Review","authors":"Win Myat Phyo ,&nbsp;Duangporn Duangthip ,&nbsp;Palinee Detsomboonrat","doi":"10.1016/j.identj.2025.103956","DOIUrl":"10.1016/j.identj.2025.103956","url":null,"abstract":"<div><div>Asylum seekers and refugees (ASRs) often experience poorer oral health outcomes than the most disadvantaged populations in their host countries. Limited information is available on the oral health-related quality of life (OHRQoL) of ASRs. This systematic review synthesized existing research on OHRQoL among ASRs populations. A systematic search was conducted in EBSCOhost (Dentistry &amp; Oral Sciences Source), PubMed, Scopus, and Google Scholar Advanced Search, without language restrictions. Two researchers independently performed the study selection and data extraction, with any discrepancies resolved through discussion with a third researcher. The citations and references of the included studies were also scrutinized to identify additional relevant literature. The inclusion criteria encompassed experimental or observational studies that evaluated OHRQoL among ASRs using at least one OHRQoL tool. Out of 141 identified, 10 studies met the inclusion criteria. All included studies primarily examined refugee populations, and none focused exclusively on asylum seekers without refugee status. These studies, published between 2014 and 2025, were conducted in United States, Turkey, India, New Zealand, Norway, Jordan, Northern Greece, Austria, and South Australia, with 1844 participants aged 4 to 76 years. Five out of ten studies (50%) measured OHRQoL by using the Oral Health Impact Profile-14. Most of the refugees were from Syria, and Arabic-language OHRQoL tools were the most commonly used (33.3%, 7/21). Physical pain domain emerged as the most frequently impacted domain of OHRQoL, ranging from 28.8% to 70.4%, across the included studies. This review highlights that refugees experience substantial impairments in OHRQoL, with the physical pain domain being the most affected. No studies on OHRQoL focusing exclusively on asylum seekers without refugee status are currently available, highlighting the need for future research to address this evidence gap.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 6","pages":"Article 103956"},"PeriodicalIF":3.7,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145266377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibulin1 as a Novel Target for Promoting the Biological Function of Bone Marrow Mesenchymal Stem Cells and Implant Osseointegration in Diabetic Patients","authors":"Yuqing Zhang ,&nbsp;Fangwen Jia ,&nbsp;Kangya Li ,&nbsp;Yuwei Yan ,&nbsp;Xiu Liu ,&nbsp;Wei Geng ,&nbsp;Chao Liang","doi":"10.1016/j.identj.2025.103928","DOIUrl":"10.1016/j.identj.2025.103928","url":null,"abstract":"<div><h3>Background and aims</h3><div>Type 2 diabetes mellitus (T2DM) is recognized as a significant risk factor affecting implant osseointegration. Our previous proteomic study revealed that Fibulin1 (FBLN1) was significantly downregulated in the alveolar bone marrow mesenchymal stem cells (BMSCs) of T2DM patients with implant failure. This study aimed to verify the effects of FBLN1 on the biological function of BMSCs and implant osseointegration in T2DM patients to identify novel intervention targets for the future development of clinical treatments.</div></div><div><h3>Materials and methods</h3><div>In in vitro experiments, FBLN1 was overexpressed in BMSCs from diabetic patients via lentiviral transduction. The effects of FBLN1 on the biological functions of BMSCs were assessed via a CCK8 assay, a wound healing assay, a Transwell assay, alkaline phosphatase staining, alizarin red staining, and subcutaneous osteogenesis analysis using nude mice. The molecular mechanism by which FBLN1 acts on BMSCs was verified via RT-qPCR and western blotting. In in vivo experiments, the effect of FBLN1 on implant osseointegration in diabetic GK rats through cell sheet–implant complexes was verified by microcomputed tomography and toluidine blue staining.</div></div><div><h3>Results</h3><div>FBLN1 was expressed in BMSCs at an early stage of the osteogenic process. CCK8, wound healing, and Transwell assays indicated that the overexpression of FBLN1 increased the proliferation and migration of BMSCs. Alkaline phosphatase staining, alizarin red staining and subcutaneous osteogenesis analysis revealed that the overexpression of FBLN1 enhanced the osteogenic differentiation of BMSCs, and RT-qPCR and western blotting revealed that FBLN1 affected this process through the FOXO1/RUNX2 signalling pathway. Microcomputed tomography and toluidine blue staining revealed that after the implantation of cell sheet–implant complexes in rats, overexpressing FBLN1 in BMSCs could restore the level of implant osseointegration in GK rats to a level similar to that in Wistar rats.</div></div><div><h3>Conclusions</h3><div>FBLN1 enhances the proliferation and migration of BMSCs from T2DM patients and promotes osteogenic function through the FOXO1/RUNX2 signalling pathway. Moreover, FBLN1 promotes implant osseointegration in diabetic GK rats, suggesting that FBLN1 is a novel target protein for increasing the success rate of dental implant surgery in T2DM patients.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 6","pages":"Article 103928"},"PeriodicalIF":3.7,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145266898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Oral Health, Oral Behaviours, and Oral Healthcare Utilisation Among Indian Migrants Living in the Netherlands","authors":"Amandeep Pabbla ,&nbsp;Charles Agyemang ,&nbsp;Irene Aartman ,&nbsp;Denise Duijster","doi":"10.1016/j.identj.2025.103946","DOIUrl":"10.1016/j.identj.2025.103946","url":null,"abstract":"<div><h3>Objectives</h3><div>The aim of this study was to assess perceptions on the role of migration on oral health, oral health behaviours, and oral healthcare utilisation among Indian migrants living in the Netherlands.</div></div><div><h3>Design</h3><div>Seven focus group discussions, with a total of 27 participants, were conducted among Indian migrants, using a semistructured interview guide. Interviews were transcribed and data were analysed using an open coding method, based on Andersen’s behavioural model. Using directed content analysis, emerging themes were organised under the main Andersen’s healthcare model.</div></div><div><h3>Results</h3><div>The analysis resulted in six identified themes on changes perceived by Indian migrants in their oral health and oral health behaviours since migrating to the Netherlands, and in seven identified themes on changes perceived in their oral healthcare utilisation and identified barriers and facilitators with oral healthcare. Migrants reported shifts in product use, with some adopting Dutch oral hygiene routines while many also continued Ayurvedic practices. Positive dietary changes, such as reduced sugar consumption, were noted. Experiences with Dutch oral healthcare utilisation were mixed: some participants highlighted facilitators including practitioner honesty, fixed pricing, preventive orientation, and welcoming clinic environments, supported by dental insurance and recall systems. At the same time, barriers emerged, particularly related to limited communication, distrust in Dutch dentists, uncertainties about malpractice procedures, and challenges in navigating the referral system.</div></div><div><h3>Conclusion</h3><div>This research highlights the complex factors associated with oral health behaviours and dental utilisation among Indian migrants in the Netherlands, emphasising the need for comprehensive consideration of cultural, socioeconomic, and environmental factors in future studies and interventions.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 6","pages":"Article 103946"},"PeriodicalIF":3.7,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145266281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}