International dental journal最新文献

{"title":"Plasmonic Optical Fibre–Based Point-of-Care Test for Periodontal MIP-1α Detection: A Validation Study of a Multiplexed Biosensor Prototype","authors":"Marco Annunziata ,&nbsp;Francesco Arcadio ,&nbsp;Emanuela Stampone ,&nbsp;Debora Bencivenga ,&nbsp;Gennaro Cecoro ,&nbsp;Chiara Marzano ,&nbsp;Angelantonio Piccirillo ,&nbsp;Fulvio Della Ragione ,&nbsp;Nunzio Cennamo ,&nbsp;Luigi Zeni ,&nbsp;Adriana Borriello ,&nbsp;Luigi Guida","doi":"10.1016/j.identj.2025.04.010","DOIUrl":"10.1016/j.identj.2025.04.010","url":null,"abstract":"<div><h3>Introduction</h3><div>The aim of this study was to assess the analytical performance of a multiplexed plasmonic optical fibre–based point-of-care test (POCT) in detecting and quantifying salivary macrophage inflammatory protein-1 alpha (MIP-1α) by comparing it with a standard enzyme-linked immunosorbent assay (ELISA).</div></div><div><h3>Methods</h3><div>Three plastic optical fibres (POFs) were modified to host a self-assembled monolayer (SAM) of anti-MIP-1α antibodies. Each of them was interposed between a light source and a spectrometer to detect the variations in the refractive index at the POF-SAM interface caused by surface plasmon resonance (SPR) when the antibody-analyte binding occurred. A dose-response Langmuir fitting curve, with MIP-1α dilutions from 0.25 to 10 pM, was calculated. Fifty salivary samples from consecutively enrolled subjects were tested by the SPR-POF biosensor and ELISA, and the obtained values were compared (Spearman’s rank correlation test). Differences in MIP-1α levels among patients based on age, gender and the presence or absence of periodontitis were also analysed (Mann-Whitney <em>U</em> test).</div></div><div><h3>Results</h3><div>A strong positive correlation between SPR-POF and ELISA measurements was found (Spearman’s r_s = 0.894, <em>P</em> &lt; .001). The SPR-POF limit of detection (LoD) was 0.15 pM, even lower than the ELISA LoD (0.78 pM). Higher (<em>P</em> &lt; .05) MIP-1α levels in periodontitis compared to non-periodontitis patients were found.</div></div><div><h3>Conclusions</h3><div>The developed 3-arm plasmonic POCT performed comparably to ELISA in detecting and quantifying salivary MIP-1α, both in terms of LoD and accuracy, with measurement rapidity and reliability enhanced by the multiplexed 3-arm design.</div></div><div><h3>Clinical Relevance</h3><div>The novel SPR-POF prototype would be of value for future studies related to POCT devices for monitoring of periodontal health and disease.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 4","pages":"Article 100830"},"PeriodicalIF":3.2,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pexidartinib Inhibits Macrophage Senescence Through Glycolysis in Periodontitis Microenvironment","authors":"Jifan Zhan ,&nbsp;Jiabing Kang ,&nbsp;Yan Wei ,&nbsp;Tianjiao Xiao ,&nbsp;Hui Fang ,&nbsp;Li Li ,&nbsp;Yiting Yuan ,&nbsp;Yongchun Zhang ,&nbsp;Jie Zhang ,&nbsp;Ai Tian","doi":"10.1016/j.identj.2025.100843","DOIUrl":"10.1016/j.identj.2025.100843","url":null,"abstract":"<div><h3>Objectives</h3><div>Periodontitis, a chronic inflammatory condition, is caused by complex interactions between periodontopathic bacteria and the local innate immune response. Macrophage senescence, a pivotal contributor to immune dysfunction, has been implicated in periodontitis progression. This research was conducted to clarify how macrophage senescence and glycolysis interact within the periodontal inflammatory microenvironment. Specifically, we investigated whether pexidartinib (PLX3397), known for inhibiting the colony-stimulating factor-1 receptor (CSF-1R), could mitigate macrophage senescence by modulating glycolytic activity, thereby attenuating periodontal inflammation.</div></div><div><h3>Methods</h3><div>We first constructed the experiential periodontitis mouse model. The alveolar bone volume was quantified using Micro-CT, while the periodontal ligament width and the distance from the cementoenamel junction (CEJ) to the alveolar bone crest (ABC) were evaluated using HE staining. The expression levels of macrophage senescence markers, glycolysis-related indicators, and CSF-1R in gingival tissues were assessed by immunofluorescence staining. For in vitro studies, Senescence was induced in RAW264.7 cells by stimulating them with <em>Porphyromonas gingivalis</em> lipopolysaccharide (<em>Pg</em>-LPS) with or without pretreatment of PLX3397 and glycolysis modulators. Cellular senescence rates were evaluated using Senescence-associated β-Galactosidase (SA-β-Gal) staining. The presence of markers indicating senescence, CSF-1R, and glycolysis-related indicators was further analysed by RT-qPCR and Western blotting.</div></div><div><h3>Results</h3><div>The gingival tissues of mice with periodontitis showed elevated senescent macrophages, which correlated with higher CSF-1R expression and glycolytic activity. Similarly, in <em>Pg</em>-LPS-treated RAW264.7 macrophages, senescence markers were upregulated alongside CSF-1R and glycolysis-related indicators. Meanwhile, modulating glycolysis in vitro directly influences senescence indicators. And PLX3397 treatment reduced glycolytic activity, leading to an improvement in macrophage senescence.</div></div><div><h3>Conclusion</h3><div>Our findings indicate that PLX3397 alleviates periodontal tissue inflammation by inhibiting macrophage senescence via glycolytic modulation, offering potential for immune-regulatory therapies in periodontitis management.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 4","pages":"Article 100843"},"PeriodicalIF":3.2,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Early and Regular Dental Visits on Dental Health Care Costs of Primary School Children in Amsterdam","authors":"Tessa S. van Ligten ,&nbsp;Denise Duijster ,&nbsp;Egija Zaura ,&nbsp;Catherine M.C. Volgenant","doi":"10.1016/j.identj.2025.100839","DOIUrl":"10.1016/j.identj.2025.100839","url":null,"abstract":"<div><h3>Objectives</h3><div>To explore whether dental visits before the age of 4 years and regular dental visits were associated with incurring dental costs at age 9 (proxy for a dental visit), and if so, what were the dental costs for primary school children in Amsterdam associated with those visits.</div></div><div><h3>Methods</h3><div>In this retrospective, longitudinal study, sociodemographic characteristics and dental costs between 2009 and 2017 were obtained from primary school children living in Amsterdam via Statistics Netherlands. Explanatory variables were whether children visited a dentist &lt;4 years of age between 2009 and 2011 (yes/no) and whether children regularly visited a dentist between 2012 and 2016 (yes/no). The outcome was dental costs at age 9 in 2017 (yes/no and the amount).</div></div><div><h3>Results</h3><div>The study population consisted of 9,519 children. Dental costs &lt;4 years of age and consecutive dental costs were associated with incurring dental costs at age 9 (aOR 2.12 [1.83-2.45]; aOR 6.48 [5.56-7.54], respectively). For those with dental costs at age 9, dental costs &lt;4 years of age were not associated with the amount of dental costs (mean difference [MD] 5.16 [-2.69-13.00]). For children incurring consecutive dental costs, dental costs at age 9 were higher than for those without (MD 17.52 [7.35-27.69]).</div></div><div><h3>Conclusions</h3><div>Early and regular dental visits were associated with increased odds of visiting a dentist at age 9 years. For children who visited a dentist at age 9 years, those with early and regular dental visits incurred slightly higher dental costs 5 years later, but mean differences were small and only the latter was significant. Therefore, early or regular dental visits do not lead to lower dental costs in the future.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 4","pages":"Article 100839"},"PeriodicalIF":3.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated Dipeptides and Agrochemicals in the Saliva of Type 2 Diabetes Mellitus Patients: A Dual Origin Metabolomic Insights","authors":"Preethi Balan ,&nbsp;Weiying Lim ,&nbsp;Yong Mong Bee ,&nbsp;Qifan Chen ,&nbsp;Fabio R.M. Leite ,&nbsp;Chaminda Jaya Seneviratne","doi":"10.1016/j.identj.2025.100836","DOIUrl":"10.1016/j.identj.2025.100836","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disorder influenced by internal metabolic disruptions and external exposures, known as exposomes, which increase disease risk. Identifying salivary metabolites is a promising method to detect biomarkers for both endogenous and environmental factors. This study utilised a dual approach to profile salivary endogenous metabolites and exposomes, aiming to provide a comprehensive understanding of T2DM by integrating biological and environmental factors, thereby improving biomarker discovery and risk prediction.</div></div><div><h3>Methods</h3><div>Salivary metabolites were analysed via ultraperformance liquid chromatography coupled with Q-Exactive mass spectrometry in samples from women with T2DM (<em>n</em> = 39) and healthy controls (<em>n</em> = 40). The groups were matched for age, sex, periodontitis, dyslipidaemia, and hypertension. The identified metabolites were mapped to the Human Metabolome Database and the Blood Exposome List using U.S. Environmental Protection Agency resources.</div></div><div><h3>Results</h3><div>Principal component analysis revealed distinct clusters for endogenous metabolites and exposomes, leading to separate analyses. In the endogenous metabolite category, 64.5% of the metabolites significantly differing between DM and non-DM groups were dipeptides (false discovery rate &lt;0.05, variable importance for the projection &gt;2). Among the dipeptides, Gln-Trp and Phe-Asn were identified as the top predictors of T2DM, with an area under the curve of 0.87, while His-Phe, His-Tyr, Met-Tyr, and Leu-Gln had area under the curve of 0.85. In the exposome category, univariate regression revealed significant associations between synthetic dipeptides and agrochemical exposomes and fasting plasma glucose levels, with daminozide exhibiting the greatest effect size.</div></div><div><h3>Conclusion</h3><div>Leveraging saliva’s noninvasive collection, these findings underscore the diagnostic potential of salivary dipeptides and emphasise the importance of addressing exposomes in T2DM management.</div></div><div><h3>Clinical relevance</h3><div>By integrating endogenous and exposome profiling, this study offers a novel approach for identifying metabolic and environmental risk factors, advancing biomarker discovery and risk prediction to improve early diagnosis and personalised management of T2DM.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 4","pages":"Article 100836"},"PeriodicalIF":3.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric Assessment of Clinical Factors in Burning Mouth Syndrome Progression","authors":"Ana Garcia-Martinez ,&nbsp;Asta Tvarijonaviciute ,&nbsp;Pia López-Jornet","doi":"10.1016/j.identj.2025.100838","DOIUrl":"10.1016/j.identj.2025.100838","url":null,"abstract":"<div><h3>Objective</h3><div>This study employed psychometric tools to assess the impact of factors such as age, symptom location, and duration on the improvement in burning mouth syndrome (BMS).</div></div><div><h3>Materials and Methods</h3><div>A total of 86 women with BMS were divided into 4 groups: laser plus clonazepam (<em>n</em> = 24), sham laser placebo (<em>n</em> = 20), laser only (<em>n</em> = 22), and clonazepam only (<em>n</em> = 20). Symptom severity was measured using the Visual Analog Scale (VAS), while depression and anxiety were evaluated using the Hospital Anxiety and Depression Scale (HADS). Stress levels were assessed using the Perceived Stress Scale (PSS) and somnolence with the Epworth Somnolence Scale (ESS). Questionnaires were completed at baseline, 1 month post-treatment, and at 3 months of follow-up.</div></div><div><h3>Results</h3><div>Symptom intensity significantly decreased from baseline to study end (<em>P</em> &lt; .001), with minor increases during follow-up. Stress levels also significantly declined (<em>P</em> = .016), while anxiety, depression, and somnolence showed no significant changes (<em>P</em> &gt; .05). Symptom intensity correlated with age (<em>P</em> &lt; .001), and initial anxiety correlated with disease duration (<em>P</em> = .027).</div></div><div><h3>Conclusion</h3><div>Age, disease duration, and symptom location did not significantly influence symptom improvement, psychological state, or somnolence. Further multidisciplinary research is needed.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 4","pages":"Article 100838"},"PeriodicalIF":3.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Accuracy and Trueness of Intraoral Scanners in Neonates With Cleft Lip and Palate: A Comparison of 3D Digital Models","authors":"Piyapat Chatborirak ,&nbsp;Krisadi Phannarus ,&nbsp;Pimsiri Kanpittaya ,&nbsp;Pintu-on Chantarawaratit","doi":"10.1016/j.identj.2025.04.014","DOIUrl":"10.1016/j.identj.2025.04.014","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>Intraoral scanners have recently emerged as a safer and more convenient alternative to traditional impression materials for capturing alveolar morphology in patients with cleft anomalies. This study aimed to assess the accuracy of 3D digital models generated by different intraoral scanners in cleft neonates. Specifically, it focused on evaluating the trueness and precision of these scanners in producing models of unilateral complete cleft lip and palate.</div></div><div><h3>Methods</h3><div>Forty plaster models of unilateral cleft lip and palate from neonates were analyzed. Inter-segment distances, consisting of 37 anterior and 23 posterior parameters, were measured manually with a digital vernier caliper as the reference. The models were scanned using 5 intraoral scanners: 3Shape TRIOS 4, iTero Element 5D, Medit i700, PANDA P2, and Straumann Virtuo Vivo. The differences between tested values (from 3D scans) and reference values were expressed as error per millimeter. Precision was evaluated by performing repeated scans and measurements on 10% of the models. Statistical analyses included 1-sample t-test, Wilcoxon test, and Friedman test, with a significance level of 0.05. Results were further validated through 3D superimposition using Geomagic Control X software.</div></div><div><h3>Results</h3><div>Observer reliability was excellent, with an ICC value of 1.000. Significant differences in trueness were found for the Medit i700 scanner, with higher errors for posterior inter-segment distances (<em>P = .</em>021) and anterior distances when compared to other scanners (<em>P = .</em>001 to .013). Precision showed excellent agreement across all scanners (ICC = 0.999 to 1.000).</div></div><div><h3>Conclusion</h3><div>While all scanners met clinical acceptability standards, the Medit i700 demonstrated lower trueness in certain parameters.</div></div><div><h3>Clinical Relevance</h3><div>This study highlights the importance of scanner selection for accurate digital model generation for cleft neonates.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 4","pages":"Article 100834"},"PeriodicalIF":3.2,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144125396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artesunate Promotes Bone Remodeling Through TRAF6-Mediated NF-κB Signaling Under Orthodontic Stress in Diabetic Rats","authors":"Yuxiang Zhan ,&nbsp;Siqin Zhang ,&nbsp;Minjie Yang ,&nbsp;Yuchen Wang ,&nbsp;Jiaquan Li ,&nbsp;Xiaolin Nong","doi":"10.1016/j.identj.2025.04.011","DOIUrl":"10.1016/j.identj.2025.04.011","url":null,"abstract":"<div><h3>Objectives</h3><div>To determine the effects of artesunate (ART) on bone remodeling <em>in vivo</em> under orthodontic stress in diabetic rats and explore the underlying mechanisms <em>in vitro</em>.</div></div><div><h3>Materials and methods</h3><div>A rat model of type 2 diabetes mellitus with orthodontic tooth movement was established. The rats received ART and/or metformin (Met) orally. The effects of ART and Met on periodontium changes were evaluated using tartrate-resistant acid phosphatase and immunohistochemical staining. Molecular docking analyses were employed to investigate the mechanisms of ART action. <em>In vitro,</em> the effects of ART on osteogenic and osteoclastic activity were explored by examining TRAF6 and NF-κB expression under hyperglycemic and static pressure conditions via immunofluorescence and Western blotting.</div></div><div><h3>Results</h3><div>ART enhanced bone metabolism despite hyperglycemia, though mechanical stress still induced bone resorption. Treatment with ART alone or in combination with Met promoted osteogenesis. TRAF6, NF-κB and the OPG/RANKL/RANK signaling pathways have been identified as key mediators of these effects. The expression of the osteogenesis-associated factor OPG increased after ART and Met treatment, while that of TRAF6 and the osteoclast-associated factors RANKL and NF-κB decreased.</div></div><div><h3>Conclusions</h3><div>Increased bone resorption and decreased bone formation are characteristics of type 2 diabetes, impacting orthodontic tooth movement. ART administration alone promotes bone remodeling under static pressure and hyperglycemic conditions. These effects are mediated by lowering blood sugar levels, inhibiting osteoclast function, and improving osteogenesis through mechanisms closely associated with the OPG/TRAF6/NF-κB signaling pathway.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 4","pages":"Article 100831"},"PeriodicalIF":3.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144090276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro Comparison of the Performance of Hydrophilic and Conventional Hydrophobic Resin-Based Fissure Sealants","authors":"Tahsin Hossain Anika ,&nbsp;Choltacha Harnirattisai ,&nbsp;Siriruk Nakornchai ,&nbsp;Varangkanar Jirarattanasopha","doi":"10.1016/j.identj.2025.04.005","DOIUrl":"10.1016/j.identj.2025.04.005","url":null,"abstract":"<div><h3>Background</h3><div>Hydrophilic sealants were developed to overcome hydrophobic sealant moisture sensitivity; however, there is still a limited understanding of their performance. This study aimed to compare microshear bond strength, penetration depth, and microleakage of hydrophilic UltraSeal XT hydro and hydrophobic Clinpro resin-based sealants placed in various surface conditions.</div></div><div><h3>Methods</h3><div>Seventy-two enamel slices and 60 molars were randomly assigned into two groups: Group 1 UltraSeal XT hydro and Group 2 Clinpro, which were further subdivided into three groups based on the enamel surface conditions (dry, slightly moist, and saliva-contaminated). After applying sealant and undergoing 5000 thermocycling cycles, microshear bond strength was tested. Additionally, penetration depth and microleakage were evaluated under a light microscope after staining with 50% silver nitrate solution.</div></div><div><h3>Results</h3><div>Group 1 demonstrated significantly higher microshear bond strength than Group 2 across all experimental conditions (<em>P</em> &lt; .001). Both sealants showed the highest microshear bond strengths under dry conditions, followed by slightly moist and saliva-contaminated conditions (<em>P</em> &lt; .001). The penetration depth between the two sealant types was comparable within each surface condition. However, both sealants showed significantly deeper penetration on dry enamel surfaces compared to slightly moist and saliva-contaminated surfaces (<em>P</em> &lt; .001). Similarly, both sealants exhibited significantly less microleakage on dry enamel surfaces compared to slightly moist and saliva-contaminated surfaces (<em>P</em> &lt; .001). While the mean microleakage value was similar between the two sealants under dry and saliva-contaminated conditions, Group 1 showed significantly lower microleakage than Group 2 under moist conditions (<em>P</em> &lt; .001).</div></div><div><h3>Conclusion</h3><div>The hydrophilic UltraSeal XT hydro sealant exhibited superior bond strength compared to the hydrophobic Clinpro sealant across all surface conditions. On slightly moist surfaces, UltraSeal XT hydro showed significantly lower microleakage than Clinpro. Both sealants exhibited superior sealing and retentive ability on dry enamel surface<strong>s</strong> compared to the other surfaces.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 4","pages":"Article 100824"},"PeriodicalIF":3.2,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Levels of Dental Anxiety in Greek Patients","authors":"Metaxia Kritsidima ,&nbsp;Sasha Scambler ,&nbsp;Koula Asimakopoulou","doi":"10.1016/j.identj.2025.04.006","DOIUrl":"10.1016/j.identj.2025.04.006","url":null,"abstract":"<div><h3>Introduction</h3><div>Dental anxiety is the apprehension experienced by an individual when confronted with matters related to dentistry, it impacts individuals' dental experiences and the dental healthcare providers’ professional lives, contributing to increased tension and potentially compromising performance. Levels of dental anxiety differ across cultures.</div></div><div><h3>Objective</h3><div>To collect normative data on levels of dental anxiety in Greece from a representative sample of people attending their usual dentist for a routine dental appointment.</div></div><div><h3>Methods</h3><div>A cross-sectional study was applied. 1313 Adults were recruited, as they attended 1 of 6 different dental settings and were scheduled for a routine dental appointment involving any of the following routine procedures: Check-up, hygiene, restoration, extraction, and pain relief. Their anxiety levels were assessed by applying the Modified Dental Anxiety Scale (MDAS), and by using the cut-off scores of 12 and 19 for assessing moderate and extreme anxiety, respectively.</div></div><div><h3>Results</h3><div>32.6% per cent of the respondents were found to be dentally anxious, out of which 8.2 % experienced high levels of dental anxiety. The mean MDAS score for the total study population was 10.36 (SD= 4.639). The findings indicated that females and first-time dental patients reported significantly higher levels of dental anxiety than males and repeat attendees. However, dental anxiety levels did not vary significantly across different dental procedures, age groups and dental settings. These results are in line with those reported by White in the U.S. population, demonstrating comparable levels of dental anxiety across both populations.</div></div><div><h3>Clinical Significance</h3><div>One in 3 patients visiting the dentist in Greece experience some level of dental anxiety. This finding underscores that dental anxiety is a prevalent public health concern in Greece. Dentists and healthcare providers should consider screening for dental anxiety that could lead to early identification and management.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 4","pages":"Article 100826"},"PeriodicalIF":3.2,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DUWL Disinfectants and Pregnancy: Is Phenyalanine a Cause for Concern?","authors":"Mawj Alalawi,&nbsp;Haider Al-Saffar","doi":"10.1016/j.identj.2025.04.009","DOIUrl":"10.1016/j.identj.2025.04.009","url":null,"abstract":"","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 4","pages":"Article 100829"},"PeriodicalIF":3.2,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}