International dental journal最新文献

筛选
英文 中文
Causal Association Between Microbiome and Oral-Oropharyngeal Cancer: A Mendelian Randomization Study 微生物组与口腔-口咽癌的因果关系:一项孟德尔随机研究。
IF 3.2 3区 医学
International dental journal Pub Date : 2025-02-21 DOI: 10.1016/j.identj.2025.01.017
Zhengrui Li , Xufeng Huang , Qi Wang , Divya Gopinath
{"title":"Causal Association Between Microbiome and Oral-Oropharyngeal Cancer: A Mendelian Randomization Study","authors":"Zhengrui Li ,&nbsp;Xufeng Huang ,&nbsp;Qi Wang ,&nbsp;Divya Gopinath","doi":"10.1016/j.identj.2025.01.017","DOIUrl":"10.1016/j.identj.2025.01.017","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>This study aimed to examine the causal link between oral microbiome and the risk of oral and oropharyngeal squamous cell carcinoma (OOPSCC) using Mendelian randomization (MR).</div></div><div><h3>Methods</h3><div>Utilizing single nucleotide polymorphisms as instrumental variables, we applied the MR inverse-variance weighted approach to assess the impact of salivary and tongue microbiome on OOPSCC. The data were obtained from the CNGBdb database and the UK Biobank, and analytical procedures were performed using the R package ‘TwoSampleMR’. To ensure the robustness of our findings, we conducted sensitivity studies, which included the MR-Egger intercept test, to establish strong correlations and eliminate the phenomenon of horizontal pleiotropy.</div></div><div><h3>Result</h3><div>Our large-scale MR study revealed a genetically predisposed causal relationship between 13 microbial taxa, each from saliva and tongue, with OOPSCC. Notably, microbial taxa from six genera, including <em>Prevotella, Neisseria, Veillonella, Granulicatella, Treponema,</em> and <em>Streptococcus</em>, in both salivary and tongue microbiomes, showed this relationship. Conversely, several taxa, including <em>Hemophilus, Solobacterium, Campylobacter,</em> and <em>Porphyromonas</em>, predominantly demonstrated an inverse relationship, suggesting a protective effect. The robustness of our findings was further confirmed through sensitivity analyses, providing additional confidence in our results.</div></div><div><h3>Conclusion</h3><div>Our MR study indicates that the oral microbiota has a significant causal impact on the risk of oral and oropharyngeal cancers. The microbial biomarkers we identified, which are linked to OOPSCC, have the potential to uncover the underlying mechanisms and pave the way for new therapeutic approaches for targeted treatment of these malignancies.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 3","pages":"Pages 1897-1905"},"PeriodicalIF":3.2,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SONOPS Multicentre Cross-Sectional Study: Study of the Nitrous Oxide Perception and Use in French Dental Students SONOPS多中心横断面研究:法国牙科学生对氧化亚氮感知和使用的研究。
IF 3.2 3区 医学
International dental journal Pub Date : 2025-02-19 DOI: 10.1016/j.identj.2025.02.007
Mélanie Duval , Maud Rodney , Morgane Rousselet , Choosie Jaquin , Elsa Garot , Thomas Marquillier , Ariane Camoin , Marion Strub , Mathieu Marty , Edouard-Jules Laforgue , Caroline Victorri-Vigneau , Tony Prud'homme
{"title":"SONOPS Multicentre Cross-Sectional Study: Study of the Nitrous Oxide Perception and Use in French Dental Students","authors":"Mélanie Duval ,&nbsp;Maud Rodney ,&nbsp;Morgane Rousselet ,&nbsp;Choosie Jaquin ,&nbsp;Elsa Garot ,&nbsp;Thomas Marquillier ,&nbsp;Ariane Camoin ,&nbsp;Marion Strub ,&nbsp;Mathieu Marty ,&nbsp;Edouard-Jules Laforgue ,&nbsp;Caroline Victorri-Vigneau ,&nbsp;Tony Prud'homme","doi":"10.1016/j.identj.2025.02.007","DOIUrl":"10.1016/j.identj.2025.02.007","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>EMONO (equimolar oxygen-nitrous oxide mixture) is widely used in dentistry to achieve sedation for dental care. In addition, pure nonmedical nitrous oxide (N2O) has become a very popular psychoactive substance among health students. Thus, for dental students, the perception of a same substance, N2O, which can either be used as medicine in the form of EMONO in their daily practice, or consumed illegally for recreational purposes in the form of pure nonmedical N2O, is of concern. This study aims to estimate the prevalence of N2O (EMONO and pure nonmedical N2O) use among French dental students.</div></div><div><h3>Methods</h3><div>A cross-sectional multicentre study was carried out in six French dental schools. A self-administered questionnaire was offered to 2nd to 6th-year odontology students about their position with regard to N2O and its potential use.</div></div><div><h3>Results</h3><div>The prevalence of N2O use among the 1124 responding students was 50.4%, with heterogeneity according to dental school. 84% of the students who used N2O did so at least once for recreational purpose, while 16% used it only in the context of care and/or training. Students with recreational N2O use were more likely to use other substances than students with care/training use. Nearly three-quarters of the students sought and experienced euphoria and laughter.</div></div><div><h3>Conclusion</h3><div>Nearly half the students in our study reported having used N2O recreationally, most of them regularly, a much higher prevalence than among nonhealthcare students.</div></div><div><h3>Clinical relevance</h3><div>The issue of the correct use of EMONO is particularly important at a time of increasing detour from medical to recreational use. As future healthcare professionals with easy access to this substance, dental students should be well versed in the use and abuse of nitrous oxide in dentistry.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 3","pages":"Pages 1855-1863"},"PeriodicalIF":3.2,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hydroxyapatite-Fluoride Toothpastes on Caries Activity: A Triple-Blind Randomized Clinical Trial 羟基磷灰石氟化物牙膏对龋齿活性的影响:一项三盲随机临床试验。
IF 3.2 3区 医学
International dental journal Pub Date : 2025-02-18 DOI: 10.1016/j.identj.2024.09.037
Fabio Cocco , Claudia Salerno , Richard Johannes Wierichs , Thomas Gerhard Wolf , Antonella Arghittu , Maria Grazia Cagetti , Guglielmo Campus
{"title":"Hydroxyapatite-Fluoride Toothpastes on Caries Activity: A Triple-Blind Randomized Clinical Trial","authors":"Fabio Cocco ,&nbsp;Claudia Salerno ,&nbsp;Richard Johannes Wierichs ,&nbsp;Thomas Gerhard Wolf ,&nbsp;Antonella Arghittu ,&nbsp;Maria Grazia Cagetti ,&nbsp;Guglielmo Campus","doi":"10.1016/j.identj.2024.09.037","DOIUrl":"10.1016/j.identj.2024.09.037","url":null,"abstract":"<div><div>The study aimed to evaluate the remineralizing effect of hydroxyapatite and fluoride containing toothpastes (HAF's) on active caries lesions compared to a fluoridated standard toothpaste in pre/schoolchildren. A total of 610 children (4-5 and 6-7 years old) were enrolled. Four toothpastes, 2 containing fluoride-substituted hydroxyapatite (HAF) (1000 and 1450 ppmF) and magnesium-, strontium-, carbonate-substituted hydroxyapatite, in a chitosan matrix and 2 Mono fluoridated toothpastes (NaMFP) (1000 and 1450 ppmF), were randomly administered for 24 months. The children were instructed to brush for 2 minutes 3 times/day. Caries activities, by clinical surface features, were recorded at baseline and 12- and 24-month follow-ups. A per-protocol analysis was adopted, thus excluding children lost to follow-up. Overall, 518 children completed the trial. Baseline comparisons revealed no significant differences in primary teeth caries rates between HAF and NaMFP groups, both for enamel and dentinal lesions. By the end of the study, the HAF group exhibited a statistically significant reduction in enamel lesions compared to the NaMFP group (<em>P</em> &lt; .01). Of the 40 partially active lesions at baseline in the HAF group, 13 were inactive at the 2-year follow-up. Of the active lesions in the HAF group (n = 78) at baseline, nearly 3-quarters (n = 58) were inactive at the follow-up. The difference between the 2 groups (HAF <em>vs</em> NaMFP) in terms of change of status in primary dentition (active at baseline and inactive at follow-up) was statistically significant (<em>P</em> = .04). Regarding dentinal lesions, both groups presented similar percentages of inactive lesions that were filled at the end of follow-up (<em>P</em> = .08). However, the HAF group demonstrated a higher number of inactivated lesions compared to the NaMFP group. The toothpaste containing biomimetic hydroxyapatite and fluoride may be better for children with active caries lesion in primary dentition.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 2","pages":"Pages 632-642"},"PeriodicalIF":3.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Piezo1 Promotes Odontogenic Differentiation of Dental Pulp Stem Cells Under Stress Conditions Piezo1促进应激条件下牙髓干细胞的成牙性分化。
IF 3.2 3区 医学
International dental journal Pub Date : 2025-02-17 DOI: 10.1016/j.identj.2025.01.018
Xiaxia Wang , Shaojie Dong , Qianqian Dong , Xuefei Sun
{"title":"Piezo1 Promotes Odontogenic Differentiation of Dental Pulp Stem Cells Under Stress Conditions","authors":"Xiaxia Wang ,&nbsp;Shaojie Dong ,&nbsp;Qianqian Dong ,&nbsp;Xuefei Sun","doi":"10.1016/j.identj.2025.01.018","DOIUrl":"10.1016/j.identj.2025.01.018","url":null,"abstract":"<div><h3>Objectives</h3><div>Mechanical stimuli signals regulate the odontogenic differentiation of dental pulp stem cells (DPSCs), but they are difficult to apply in clinical treatment. Piezo1, a specific mechanically activated ion channel that mediates mechanical transduction, may serve as a potential target for regulating mechanical signals. In the present study, we aimed to investigate the function and potential molecular mechanisms of Piezo1 in the odontogenic differentiation of DPSCs.</div></div><div><h3>Methods</h3><div>Piezo1 expression in human dental pulp and DPSCs was detected by immunofluorescence or immunohistochemistry (IHC). The mechanotransduction of Piezo1 ion channels in DPSCs was determined by fluid shear stress (FSS) detection of calcium fluorescence intensity and whole-cell patch clamp detection. The role of Piezo1 in the odontogenic differentiation of DPSCs was detected by alizarin red staining and Western blotting under hydrostatic pressure (HP). The expression and distribution of the downstream molecules Piezo1, CaN, and YAP were detected through coimmunoprecipitation (co-IP), immunocytochemistry (ICC), and Western blot analysis.</div></div><div><h3>Results</h3><div>The Piezo1 protein was positively expressed in human dental pulp samples, especially in the odontoblast layer. Increased Piezo1 expression was also detected after odontogenic differentiation of DPSCs in vitro. The fluorescence intensity of intracellular calcium ions (Ca<sup>2+</sup>i) increased rapidly with treatment with FSS or Yoda1 (a Piezo1-specific agonist) but did not significantly change after treatment with GsMTx4 (a Piezo1 antagonist) or BAPTA (an extracellular calcium ion chelating agent). A whole-cell patch clamp was used to record the inward current induced by mechanical stimulation of the DPSCs. After Yoda1 treatment, the peak current increased, but the currents nearly completely disappeared after pretreatment with GsMTx4. In addition, we found that blocking CaN or YAP reversed the ability of HP to promote DPSC odontogenic differentiation. Co-IP and ICC revealed that the CaN and YAP proteins colocalized and bound to each other in DPSCs.</div></div><div><h3>Conclusions</h3><div>These findings indicated that the Piezo1 ion channel mediates the mechanical transduction of DPSCs. In addition, Piezo1 promotes odontogenic differentiation of DPSCs through the Ca<sup>2+</sup>/CaN/YAP signalling axis under HP, which provides effective intervention targets for mechanical stimulation-mediated regulation of reparative dentin and vital pulp preservation.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 3","pages":"Pages 1885-1896"},"PeriodicalIF":3.2,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aerosol Dispersion and Efficacy of Protective Strategies During Dental Procedures 牙科治疗过程中气溶胶的分散和防护策略的有效性。
IF 3.2 3区 医学
International dental journal Pub Date : 2025-02-12 DOI: 10.1016/j.identj.2025.01.015
Mustafa Radif, Andrew Young, Eric Salmon, David M. Ojcius, Shika Gupta
{"title":"Aerosol Dispersion and Efficacy of Protective Strategies During Dental Procedures","authors":"Mustafa Radif,&nbsp;Andrew Young,&nbsp;Eric Salmon,&nbsp;David M. Ojcius,&nbsp;Shika Gupta","doi":"10.1016/j.identj.2025.01.015","DOIUrl":"10.1016/j.identj.2025.01.015","url":null,"abstract":"<div><h3>Introduction and Aims</h3><div>Aerosol generation during dental procedures poses significant risks due to the potential for transmitting aerosol-bound microorganisms, including those in dental unit waterlines. This study aimed to quantify aerosol dispersion at various distances from dental procedures using a high-speed electric handpiece, with a focus on the effectiveness of various aerosol mitigation strategies.</div></div><div><h3>Methods</h3><div>Employing a mannequin head with an artificial tooth (typodont), we simulated clinical settings without the use of saliva to solely assess the contribution of dental unit waterlines and mechanical factors to aerosol production. Measurements were taken using a spectrometer at distances of 0, 0.9, and 1.8 meters from the handpiece.</div></div><div><h3>Results</h3><div>The results showed no significant difference in aerosol dispersion between 0.9 and 1.8 meters without evacuation. In contrast, the use of high-volume evacuators, particularly the Isolite system, significantly decreased aerosol dispersion across all distances.</div></div><div><h3>Conclusion</h3><div>We found that any type of high-volume evacuator can decrease aerosol dispersion, but the use of Isolite was the most effective.</div></div><div><h3>Clinical Relevance</h3><div>The results from this study can influence choice of safety measures to minimize aerosol spread during dental procedures.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 3","pages":"Pages 1906-1912"},"PeriodicalIF":3.2,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Poor Oral Hygiene: A Hidden Risk Factor for Helicobacter pylori Infection 口腔卫生不良:幽门螺杆菌感染的潜在危险因素。
IF 3.2 3区 医学
International dental journal Pub Date : 2025-02-12 DOI: 10.1016/j.identj.2025.01.001
Xiao Zhao , Xiao She , Haiyan Yang , Ziqin Zeng , Weicheng Zhi , Yan Jing , Lei Dong , Jun Gong , Haitao Guan , Ping Zhao
{"title":"Poor Oral Hygiene: A Hidden Risk Factor for Helicobacter pylori Infection","authors":"Xiao Zhao ,&nbsp;Xiao She ,&nbsp;Haiyan Yang ,&nbsp;Ziqin Zeng ,&nbsp;Weicheng Zhi ,&nbsp;Yan Jing ,&nbsp;Lei Dong ,&nbsp;Jun Gong ,&nbsp;Haitao Guan ,&nbsp;Ping Zhao","doi":"10.1016/j.identj.2025.01.001","DOIUrl":"10.1016/j.identj.2025.01.001","url":null,"abstract":"<div><h3>Background</h3><div><em>Helicobacter pylori</em> (<em>H. pylori</em>) initially enters the human body through the mouth. The correlation between oral health and <em>H. pylori</em> infection status remains a topic of debate in the scientific literature. To elucidate the relationships between <em>H. pylori</em> infection and oral hygiene status and habits, we performed a cross-sectional study among dyspeptic patients.</div></div><div><h3>Methods</h3><div>Data were collected from 362 subjects with dyspepsia symptoms who underwent the 13C-urea breath test (13C-UBT) and the <em>H. pylori</em> antigen test (HPS) to test for gastric and oral <em>H. pylori</em> infections between May and August 2023 at The Second Affiliated Hospital of Xi'an Jiaotong University. The participants completed questionnaires on sociodemographic characteristics, medical history, dyspepsia symptoms, oral hygiene status, and oral hygiene practices. In addition, the participants underwent oral exams involving the simplified oral hygiene index (OHI-S), the Debris index (DI-S), the simplified calculus index (CI-S), and the decayed, missing, and filled teeth (DMFT) score.</div></div><div><h3>Results</h3><div>Oral <em>H. pylori</em> infection status was not associated with sex, body mass index (BMI), education, oral hygiene habits, place of residence, or income. Considering sex and BMI, being over 60 years of age significantly increased the risk of developing oral <em>H. pylori</em> infection (OR = 5.51, 95% CI: 1.56-19.46, <em>P</em> = .0081), whereas a lack of history of antibiotic use was identified as a protective factor (OR = 0.45, 95% CI: 0.26-0.77, <em>P</em> = .0036). Additionally, DMFT &gt;4 (OR = 2.54, 95% CI: 1.15-5.61, <em>P</em> = .0210), 0.67 &lt; OHI-S ≤ 1.33 (OR = 1.98, 95% CI: 1.09-3.59, <em>P</em> = .0246), and 0.33&lt;DI≤0.67 (OR = 2.00, 95% CI: 1.11-3.62, <em>P</em> = .0215) were identified as independent risk factors for oral <em>H. pylori</em> infection.</div></div><div><h3>Conclusion</h3><div>The results of our research indicate a relationship between oral health and oral <em>H. pylori</em> infection, suggesting that poor oral hygiene may be associated with an increased risk of oral <em>H. pylori</em> colonization.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 3","pages":"Pages 2115-2121"},"PeriodicalIF":3.2,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomechanical Evaluation of Cantilevered 2-Unit Implant-Supported Prostheses: A 3D Finite Element Study 悬臂式2单元种植体支撑假体的生物力学评价:三维有限元研究。
IF 3.2 3区 医学
International dental journal Pub Date : 2025-02-11 DOI: 10.1016/j.identj.2025.01.014
Hatem S. Sadek , Noha M. Anany , Al-Hassan Diab , Mohamed I. El-Anwar , Abdulaziz Alhotan , Mostafa Aldesoki , Christoph Bourauel , Tarek M. Elshazly
{"title":"Biomechanical Evaluation of Cantilevered 2-Unit Implant-Supported Prostheses: A 3D Finite Element Study","authors":"Hatem S. Sadek ,&nbsp;Noha M. Anany ,&nbsp;Al-Hassan Diab ,&nbsp;Mohamed I. El-Anwar ,&nbsp;Abdulaziz Alhotan ,&nbsp;Mostafa Aldesoki ,&nbsp;Christoph Bourauel ,&nbsp;Tarek M. Elshazly","doi":"10.1016/j.identj.2025.01.014","DOIUrl":"10.1016/j.identj.2025.01.014","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the biomechanical performance of cantilevered 2-unit implant-supported prostheses with zirconia and polyetherketoneketone (PEKK) under 3 loading conditions.</div></div><div><h3>Method</h3><div>A cone beam computer tomography (CBCT) scan of an edentulous mandible was segmented using Mimics software and refined in 3-Matic software to create trabecular and cortical bone structures. Implant CAD files were integrated using SolidWorks software, generating 4 models with varying implant positions: M1 (first premolar implant supporting a second premolar), M2 (second premolar implant supporting a first premolar), M3 (second premolar implant supporting a first molar), and M4 (first molar implant supporting a second premolar). Prostheses were constructed from zirconia or PEKK. Finite element analysis (FEA) in ANSYS software simulated static loading: vertical (100 N) and oblique (30° and 45°, 50 N). von Mises stress and total deformation were analyzed.</div></div><div><h3>Results</h3><div>Vertical loading showed the highest von Mises stress at cantilever connectors, with M3 displaying the highest cortical bone stress (117 MPa). Zirconia models had slightly higher prosthetic stress, while PEKK models exhibited greater implant and cortical bone stress. Oblique loading caused higher stress in implants and prostheses but remained below yield limits. Maximum deformation was under 25 micrometers for the implant and bone, and 65 micrometers for the prosthesis.</div></div><div><h3>Conclusion</h3><div>Single implants can support 2-unit cantilevered prostheses when additional implants are unfeasible. The location of the cantilever has minimal impact compared to its size, as a larger cantilevered part increases stress. Zirconia better resists bending forces and reduces implant stress compared to PEKK.</div></div><div><h3>Clinical significance</h3><div>This study guides prosthodontists in designing 2-unit implant-supported prostheses, emphasizing that multiple implants optimize stress distribution, and that zirconia is preferable for cantilevered designs.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 3","pages":"Pages 1913-1920"},"PeriodicalIF":3.2,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation Between miR-27a-3p Polymorphisms and Peri-Implantitis Susceptibility: A Case-Control Study miR-27a-3p多态性与种植体周围炎易感性的相关性:一项病例对照研究
IF 3.2 3区 医学
International dental journal Pub Date : 2025-02-10 DOI: 10.1016/j.identj.2025.01.013
Xiaojie Gao , Yanan Ha
{"title":"Correlation Between miR-27a-3p Polymorphisms and Peri-Implantitis Susceptibility: A Case-Control Study","authors":"Xiaojie Gao ,&nbsp;Yanan Ha","doi":"10.1016/j.identj.2025.01.013","DOIUrl":"10.1016/j.identj.2025.01.013","url":null,"abstract":"<div><h3>Background</h3><div>Peri-implantitis (PI) is characterised by a chronic inflammatory response that affects both the soft and bone tissues around dental implants. Inflammatory condition, coupled with alterations in bone metabolism, may be modulated by miR-27a-3p.</div></div><div><h3>Aim</h3><div>This research aims to investigate the relationship between miR-27a-3p rs895819 polymorphism with PI susceptibility, along with its effects and mechanism on inflammatory factors.</div></div><div><h3>Methods</h3><div>Relative miR-27a-3p level was assessed using reverse transcription-polymerase chain reaction (RT-PCR). rs895819 was genotyped by restriction fragment length polymorphism. Enzyme-linked immunosorbent assay (ELISA) kits detected the concentrations of RUNX1, C-reactive protein (CRP), and interleukin-6 (IL-6). Overlapping target genes of miR-27a-3p were identified from databases, including ENCORI, miRDB, and TargetScan databases, which facilitated the selection of target genes of miR-27a-3p. Overlap genes were compiled by the Venn diagram. Functional enrichment analysis for target genes was performed via Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Protein-Protein Interaction (PPI) networks.</div></div><div><h3>Results</h3><div>Underexpressed miR-27a-3p was discovered in PI patients. GG genotype (crude: odds ratio (OR) = 2.898, 95% confidence interval (CI) = 1.419-5.917; adjusted: OR = 2.157, 95% CI = 1.045-4.455) and G allele (<em>P</em> = .003, OR = 1.501, 95% CI = 1.144-1.968) of rs895819 demonstrates a significant association with an enhanced PI susceptibility. The direct target gene RUNX1 has been identified from these databases. PI patients possessing rs895819 GG genotype exhibit diminished level of miR-27a-3p and elevated concentrations of RUNX1 (<em>P</em> &lt; .05), CRP (<em>P</em> &lt; .001), IL-6 (<em>P</em> &lt; .001), and white blood cell (WBC) count (<em>P</em> &lt; .05).</div></div><div><h3>Conclusion</h3><div>These results suggest that rs895819 of miR-27a-3p serves as a significant risk predictor for PI patients. This variant is associated with decreased miR-27a-3p levels, alongside elevated RUNX1 levels and inflammatory factor levels in PI patients.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 3","pages":"Pages 1921-1928"},"PeriodicalIF":3.2,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral Cancer Knowledge and Screening Practices Among Dental Professionals in Yemen: a Web-Based Survey 口腔癌知识和筛查实践中牙科专业人员在也门:一个基于网络的调查。
IF 3.2 3区 医学
International dental journal Pub Date : 2025-02-07 DOI: 10.1016/j.identj.2024.12.034
Sadeq Ali Al-Maweri , Esam Halboub , Anas Shamala , Abdulrazzaq Ahmed Al-Maweri , Alaa Daud , Ebrahim Almurisi , Asma Saleh Almeslet , Saba Kassim , Mohammed Nasser Alhajj
{"title":"Oral Cancer Knowledge and Screening Practices Among Dental Professionals in Yemen: a Web-Based Survey","authors":"Sadeq Ali Al-Maweri ,&nbsp;Esam Halboub ,&nbsp;Anas Shamala ,&nbsp;Abdulrazzaq Ahmed Al-Maweri ,&nbsp;Alaa Daud ,&nbsp;Ebrahim Almurisi ,&nbsp;Asma Saleh Almeslet ,&nbsp;Saba Kassim ,&nbsp;Mohammed Nasser Alhajj","doi":"10.1016/j.identj.2024.12.034","DOIUrl":"10.1016/j.identj.2024.12.034","url":null,"abstract":"<div><h3>Background</h3><div>Good knowledge and screening practices of dental professionals for oral cancer (OC) will inevitably improve its prognosis. The present study sought to evaluate OC knowledge and practices among dental professionals in Yemen.</div></div><div><h3>Methods</h3><div>This study was conducted among Yemeni dentists. The used tool was a prevalidated online questionnaire composed of items on the knowledge, practices, and barriers of OC screening and early detection. The data were managed and analysed using SPSS Version 28.0.</div></div><div><h3>Results</h3><div>A total of 506 dental professionals completed the questionnaire. The participants showed moderate levels of knowledge on risk factors and clinical signs of OC. While the majority reported tobacco (89.9%) as a potential risk factor, only 76.7% and 57.5% of the subjects reported a potential role for alcohol consumption and old age. Regarding clinical signs, the majority reported that OC can present as nonhealing ulcer (90.3%) or white/red patch (87.2%), yet only 73.7% reported that it can present as swelling/lump, and around 32% reported that teeth attrition is one of its clinical signs. Concerning practices, most of the participants reported asking their patients about their tobacco habits (84%), routinely examine patients’ oral mucosa (81.4%), and refer suspicious lesions to specialists (91.3%). Only 44.9% reported feeling confident regarding their knowledge and training on OC. Specialists and those who attended educational courses on OC were more knowledgeable, more confident, and showed better practices than their counterparts. Inadequate knowledge/training, lack of time, and lack of financial compensation were the most reported barriers to OC screening and early detection.</div></div><div><h3>Conclusion</h3><div>The present study indicates marked gaps in the knowledge and screening practices of OC among Yemeni dentists. Therefore, conducting periodic continuing courses along with interventional trainings are urgently recommended to address these gaps.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 3","pages":"Pages 2034-2041"},"PeriodicalIF":3.2,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sector-differences in Adults’ Dental Care Service Utilisation: 11-year Register-based Observations 成人牙科保健服务利用的部门差异:11年基于登记的观察。
IF 3.2 3区 医学
International dental journal Pub Date : 2025-02-06 DOI: 10.1016/j.identj.2024.12.035
Miira M. Vehkalahti , Ulla Palotie , Sinikka Varsio , Kaija Hiltunen
{"title":"Sector-differences in Adults’ Dental Care Service Utilisation: 11-year Register-based Observations","authors":"Miira M. Vehkalahti ,&nbsp;Ulla Palotie ,&nbsp;Sinikka Varsio ,&nbsp;Kaija Hiltunen","doi":"10.1016/j.identj.2024.12.035","DOIUrl":"10.1016/j.identj.2024.12.035","url":null,"abstract":"<div><h3>Objective</h3><div>This register-based study evaluated sector-specific differences in adults’ utilisation of dental care services in Helsinki, Finland in 2007-2017.</div></div><div><h3>Methods</h3><div>The target population comprised all inhabitants aged 20+ years in Helsinki over an 11-year period, from 2007 to 2017. The data, aggregated into 5-year age groups by treatment year and type of treatment, included inhabitants with at least 1 visit to a dentist in the private or public sector. In 2007-2017, the numbers of all patients ranged between 229,772 and 261,488. The patient age groups were analysed for periodontal, restorative, endodontic, and oral surgery treatment received. Attendance rates (%) refer to the number of patients per number of inhabitants. Proportions (%) of patients receiving various treatment types refer to numbers of patients per all patients. Comparisons between the age groups included percentual change in absolute numbers and percentage points in rates. The treatment-year trends were analysed by applying linear regression models.</div></div><div><h3>Results</h3><div>Attendance rate for all adult patients was 49.5% in 2007 and 48.8% in 2017. During the 11-year period, adults’ attendance to private service decreased (31.4%-24.9%) but increased to public service (18.1%-23.9%). Patients receiving periodontal care increased in both the private (67%-72%) and public (36%-45%) sectors, while patients with restorative care decreased in both sectors private (67%-58%) and public (58%-48%). Further, fewer private- than public-sector patients received oral surgery or endodontic treatment.</div></div><div><h3>Conclusions</h3><div>Sector-specific differences in patient treatments may indicate over- or undertreatment choices in restorative and periodontal care.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 3","pages":"Pages 2025-2033"},"PeriodicalIF":3.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信