International dental journal最新文献

{"title":"Craniofacial, Dental, and Upper Airway Morphologic features of Severely Obese Adults with Obstructive Sleep Apnea","authors":"Liang Xia ,&nbsp;Wenxin Jiang ,&nbsp;Kan Yao ,&nbsp;Hongxia Sun ,&nbsp;Xiaofeng Lu ,&nbsp;Wenwen Yu","doi":"10.1016/j.identj.2025.02.021","DOIUrl":"10.1016/j.identj.2025.02.021","url":null,"abstract":"<div><h3>Introduction and Aims</h3><div>Craniofacial and upper airway development are closely associated with obstructive sleep apnea (OSA). This study aimed to analyse craniofacial and upper airway characteristics in adults with severe obesity and OSA to better understand the disease.</div></div><div><h3>Methods</h3><div>Ninety-four severely obese patients (BMI ≥ 35) underwent polysomnography (PSG) and lateral cephalograms to assess craniofacial and upper airway morphology. Cephalometric and airway measurements were analysed combined with PSG findings to evaluate craniofacial and airway features in severe OSA patients.</div></div><div><h3>Results</h3><div>The study included 50 males and 44 females, with a mean age of 33.05 years and an average apnea-hypopnea index (AHI) of 52.22 events/h. Males had significantly higher AHI, neck circumference (NC), waist circumference, and arousal index, along with lower average and minimal oxygen saturation levels compared to females. Cephalometric analysis showed that males had greater mandibular ramus length and Sella-to-condyle vertical distance. Cross-correlation analysis indicated significant associations between AHI and both NC and the mandibular plane to Sella-Nasion line measurement. The Frankfurt horizontal plane to Nasion–Pogonion plane was correlated with BMI, NC, and waist circumference. Hyoid bone position was linked to tongue volume, Y-axis angle, pharyngeal airway space, facial height, and lip length. Tongue volume correlated with mandibular ramus length, upper anterior tooth angle, and upper lip length. Snoring index was associated with pharyngeal airway space and tongue height, while pharyngeal airway space width was related to oxygen saturation levels.</div></div><div><h3>Conclusion</h3><div>Severe obese individuals, particularly males, experience more severe OSA symptoms. A complex interplay exists between OSA, craniofacial morphology, and airway structure.</div></div><div><h3>Clinical Relevance</h3><div>Craniofacial and dental features are consistent in severe obese OSA patients, suggesting that obesity-related fat accumulation has a greater impact on respiratory function than skeletal structure or dental alignment.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Simulation of Glued Contact Sufficient to Simulate Nonlinear Failure Behaviour in Dental Shear Bond Strength Tests?","authors":"Ahmed M. Ismail ,&nbsp;Ahmed ElBanna ,&nbsp;Tamer M. Nassef ,&nbsp;Ludger Keilig ,&nbsp;Christoph Bourauel","doi":"10.1016/j.identj.2025.03.007","DOIUrl":"10.1016/j.identj.2025.03.007","url":null,"abstract":"<div><div>The aim of this study was to develop a numerical model for simulating shear bond strength tests with different specimen sizes and loading techniques. A finite element model was generated consisting of a composite specimen bonded to dentin substrate surrounded by enamel, acrylic resin and polypropylene tube. Four models were created simulating macro (diameter 1.8 mm) and micro (0.8 mm) sized specimens loaded by either a chisel or a wire loop. Experimental data from a previously published study using the identical specimen diameter and shearing tools were used as reference. Four groups were established: macro shear wire loop (group 1), micro shear wire loop (group 2), macro shear chisel (group 3), and micro shear chisel (group 4). In the simulations, contact-based glue failure based on shear contact stresses (series 1) or a combination of shear and normal contact stresses (series 2) were used to simulate the progressive failure of the specimens. Shear and normal failure stress limits were fitted to the experimental results in sensitivity analyses by varying both stresses. Experimental failure forces could be reproduced using group-specific shear stress limits of 71 (group 1), 48 (group 2), 106 (group 3), and 131 MPa (group 4) in series 1. However, when also considering normal stresses, no single, unique pair of shear and normal failure stresses can lead to the experimental failure force values for all groups. In conclusion, no unique pair of shear and normal stresses can provide the same failure force values for different shear setup geometries.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 3","pages":"Pages 1746-1758"},"PeriodicalIF":3.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dentistry and Travel Medicine – What is Keeping Them Apart?","authors":"Irmgard L. Bauer","doi":"10.1016/j.identj.2025.03.014","DOIUrl":"10.1016/j.identj.2025.03.014","url":null,"abstract":"","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 3","pages":"Page 1745"},"PeriodicalIF":3.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Making the Right to Oral Health a Reality for Older Adults","authors":"Kakuhiro Fukai,&nbsp;Sophie Dartevelle,&nbsp;Judith Jones,&nbsp;Gerry McKenna,&nbsp;Hirohiko Hirano,&nbsp;FDI World Dental FederationAll authors are member of FDI's Oral Health for an Ageing Population Task Team","doi":"10.1016/j.identj.2025.02.010","DOIUrl":"10.1016/j.identj.2025.02.010","url":null,"abstract":"","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 3","pages":"Pages 1732-1735"},"PeriodicalIF":3.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Somatic Symptoms as Idioms of Distress in East Asian Patients With Differing Temporomandibular Disorder Diagnostic Subtypes","authors":"Adrian Ujin Yap ,&nbsp;Sunghae Kim ,&nbsp;Jung Hwan Jo ,&nbsp;Byeong-min Lee ,&nbsp;Ji Woon Park","doi":"10.1016/j.identj.2025.03.010","DOIUrl":"10.1016/j.identj.2025.03.010","url":null,"abstract":"<div><h3>Objective</h3><div>This cross-sectional study investigated the prevalence/severity of somatic symptoms, their relationship with psychological distress and oral behaviors in different temporomandibular disorder (TMD) diagnostic subtypes, and identified biopsychosocial factors associated with depression, anxiety, and jaw overuse behavior among East Asian patients.</div></div><div><h3>Methods</h3><div>Anonymized data from consecutive new TMD patients at a tertiary oral medicine clinic were evaluated. TMD diagnoses were determined using the DC/TMD methodology, while somatic symptoms, depression, anxiety, and oral behaviors were assessed with the Patient Health Questionnaire (PHQ)-15, PHQ-9, Generalized Anxiety Disorder Scale-7, and Oral Behavior Checklist. Data were examined using the Chi-square/non-parametric tests and multivariate linear regression analysis (α = 0.05).</div></div><div><h3>Results</h3><div>Among the 699 patients, somatic symptoms were present in 36.8%, 54.0%, and 48.2% of individuals with intra-articular (IT), pain-related (PT), and combined (CT) TMDs respectively. Significant differences in somatic symptom burden/depression (PT, CT &gt; IT) and anxiety (CT &gt; IT) were observed. For all TMD subtypes, patients with somatic symptoms showed significantly greater depression, anxiety, and jaw overuse behavior compared to those without somatic symptoms. Somatic symptoms were moderately correlated with depression and anxiety (<em>r_s</em> = 0.51-0.65).</div></div><div><h3>Conclusion</h3><div>Somatic symptom burden was linked to depression and anxiety, supporting the phenomenon of somatization across different TMD subtypes.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 3","pages":"Pages 1713-1721"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circ_0003072 Mediates the Pro-osteogenic Differentiation Effect of Betulinic Acid on Human Periodontal Ligament Stem Cells.","authors":"Yuesun Qi, Chunnan Lin, Chengwei Zhao, Ye Wu","doi":"10.1016/j.identj.2024.10.017","DOIUrl":"10.1016/j.identj.2024.10.017","url":null,"abstract":"<p><strong>Background: </strong>Betulinic acid (BetA) exhibits a good pro-osteogenic differentiation effect on human periodontal ligament stem cells (hPDLSCs), making it a promising supplement for periodontal regeneration. Circular RNAs (circRNAs) have emerged as important regulators of cellular behaviour, and whether circRNAs are involved in the effects of BetA remains unknown.</p><p><strong>Methods: </strong>Bioinformatics analysis was used to screen for dysregulated circRNAs involved in osteogenic differentiation based on public datasets. Osteogenic differentiation was evaluated using quantitative PCR detection of RUNX2, ALPL, COL1A1, and BGLAP levels, alkaline phosphatase staining, and Alizarin Red S staining of calcified nodules. The role of circ_0003072 in the BetA-regulated osteogenic differentiation of hPDLSCs was investigated, and its downstream microRNAs and mRNA were confirmed using RNA-sequencing, competing endogenous RNA network construction, gene ontology analysis, dual-luciferase reporter assays, and functional assays.</p><p><strong>Results: </strong>circ_0003072 showed the highest fold-change among the 18 candidate circRNAs, and knockdown of circ_0003072 inhibited the pro-osteogenic differentiation effect of BetA on hPDLSCs. RNA-sequencing combined with gene ontology analysis identified 11 osteogenesis-relevant genes. Five genes that shared microRNAs between circ_0003072 and two candidate genes (chordin-like 1 [CHRDL1] and XIAP) were screened, and miR-488-3p showed the highest increase after silencing circ_0003072. Knockdown of circ_0003072 inhibited the pro-osteogenic differentiation effect of silencing miR-488-3p. miR-488-3p bound to circ_0003072 and CHRDL1. Furthermore, overexpression of CHRDL1 rescued the miR-488-3p-induced inhibition of osteogenic differentiation.</p><p><strong>Conclusion: </strong>BetA promoted the osteogenic differentiation of hPDLSCs by regulating the circ_0003072/miR-488-3p/CHRDL1 pathway, and circ_0003072 acted as a sponge for miR-488-3p, thus upregulating the level of CHRDL1.</p>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":"1390-1399"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Electronic Cigarettes on Oral Microbiome and Metabolome in 3D Tissue-Engineered Models: Comment.","authors":"Amnuay Kleebayoon, Viroj Wiwanitkit","doi":"10.1016/j.identj.2025.01.004","DOIUrl":"10.1016/j.identj.2025.01.004","url":null,"abstract":"","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":"1450-1451"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron Status and Risk of Periodontitis and Dental Caries: A Mendelian Randomization Study.","authors":"Jiaqi Wu, Ziyang Zheng, Jinghan Wang, Weiwei Xiao, Liang Shi, Liyuan Fan","doi":"10.1016/j.identj.2024.11.018","DOIUrl":"10.1016/j.identj.2024.11.018","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have indicated a potential relationship between iron status and oral health outcomes, specifically periodontitis and dental caries. This study employed Mendelian randomization (MR) to investigate the causal effects of iron status on these oral health conditions. The focus of this study was on key iron biomarkers, namely serum iron, ferritin, transferrin saturation (TSAT), and total iron-binding capacity (TIBC).</p><p><strong>Methods: </strong>This two-sample MR analysis employed genome-wide association study (GWAS) data. The instrumental variables (IVs) were selected based on their genome-wide significance and independence from confounders. The statistical analyses employed the inverse variance weighted (IVW) method, MR-Egger regression, weighted median, and weighted mode. Additionally, sensitivity analyses were conducted to verify the reliability of the causal association results.</p><p><strong>Results: </strong>The MR analysis indicated a suggestive negative causal relationship between TIBC and periodontitis, with an odds ratios of 0.875 and a 95% CI of 0.766-0.998, with a P-value of .047. No significant other associations were found. The results of sensitivity analyses demonstrated the robustness of these findings.</p><p><strong>Conclusion: </strong>This MR study suggested a potential negative association between TIBC and periodontitis, highlighting the importance of considering iron status in the clinical management of chronic periodontitis. However, more standardized, multi-population studies are needed to confirm this causality.</p>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":"1441-1449"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteogenic Induction Activity of Magnesium Chloride on Human Periodontal Ligament Stem Cells.","authors":"Supanat Lumbikananda, Kittiphoj Tikkhanarak, Sarai Pongjantarasatian, Vorapat Trachoo, Worachat Namangkalakul, Thanaphum Osathanon","doi":"10.1016/j.identj.2024.11.013","DOIUrl":"10.1016/j.identj.2024.11.013","url":null,"abstract":"<p><strong>Objectives: </strong>Periodontal ligament stem cells (PDLSCs) are promising for regenerative therapies due to their self-renewal and multilineage differentiation, essential for periodontal tissue repair. Although magnesium plays a vital role in bone metabolism, its specific effects on PDLSCs and potential applications in regeneration are unclear. This study aimed to investigate the effects of magnesium chloride (MgCl₂) on the proliferation and osteogenic differentiation of human PDLSCs (hPDLSCs).</p><p><strong>Methods: </strong>hPDLSCs were isolated, characterised, and treated with 0.1-40 mM MgCl₂. Cell viability and proliferation were assessed using an MTT assay. Cell migration was measured by a scratch assay. Colony-forming unit formation and cell cycle analysis were examined using crystal violet and propidium iodide staining. Osteogenic differentiation was assessed through alkaline phosphatase activity, Alizarin Red S staining, and RT-qPCR for osteogenic-related gene expression. RNA sequencing was performed to evaluate differential gene expression patterns in hPDLSCs treated with 10 mM MgCl₂. All statistical analyses were evaluated at P < .05.</p><p><strong>Results: </strong>hPDLSCs exhibited mesenchymal stem cell characteristics. MgCl₂ concentrations higher than 10 mM were cytotoxic. Significant increases in cell proliferation, colony-forming unit percentages, and active cell cycle activity were observed when treated with 0.1, 0.5, and 1 mM MgCl₂. However, MgCl₂ had no effect on cell migration. Mineralised nodule formation was observed in hPDLSCs treated with 0.1 and 0.5 mM MgCl₂ in osteogenic induction media, mediated by TRPM7 cation channel, along with upregulated expression of osteogenic marker genes. Bioinformatic analysis indicated alterations in chemokine signalling and cellular calcium homeostasis pathways when treated with 10 mM MgCl₂.</p><p><strong>Conclusions: </strong>MgCl₂ at a dose of 0.1 mM is the most effective concentration to promote cell proliferation and stimulate osteogenic differentiation of hPDLSCs in vitro. These findings indicate that MgCl₂ enhances both the proliferation and osteogenic differentiation of hPDLSCs, supporting its potential application in periodontal tissues and alveolar bone regeneration.</p>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":"1431-1440"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Numbering System for Teeth Following Hemisection, Bicuspidisation, and Root Resection.","authors":"Manali Ramakrishnan Srinivasan, Saravanan Poorni, Liran Levin, Paul Mh Dummer, Venkateshbabu Nagendrababu","doi":"10.1016/j.identj.2024.12.028","DOIUrl":"10.1016/j.identj.2024.12.028","url":null,"abstract":"","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":"1452-1454"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}