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Evaluating the Effect of Telomere Length on Oral and Oropharyngeal Cancer Risk Using Mendelian Randomization. 利用孟德尔随机法评估端粒长度对口腔癌和口咽癌风险的影响
IF 3.2 3区 医学
International dental journal Pub Date : 2024-09-21 DOI: 10.1016/j.identj.2024.07.1218
Li Lan, Ruizhe Zhang, Ya Liang, Huarong Chen, Houyu Zhao, Xianlu Zhuo
{"title":"Evaluating the Effect of Telomere Length on Oral and Oropharyngeal Cancer Risk Using Mendelian Randomization.","authors":"Li Lan, Ruizhe Zhang, Ya Liang, Huarong Chen, Houyu Zhao, Xianlu Zhuo","doi":"10.1016/j.identj.2024.07.1218","DOIUrl":"https://doi.org/10.1016/j.identj.2024.07.1218","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to explore the causal relationship between telomere length and Oral and oropharyngeal cancers by using Mendelian randomization (MR) analysis.</p><p><strong>Methods: </strong>We carried out a 2-sample MR to examine the causal association between telomere length and Oral and oropharyngeal cancers. Two large genome-wide association studies (GWAS) were employed to identify single nucleotide polymorphisms (SNPs) as instrumental variables through statistical and biological approaches. The data on SNP-oral and oropharyngeal cancer risk factor associations were sourced from various consortia/UK Biobank. The inverse variance weighted (IVW) method was employed as the primary approach for overall causal estimation in MR, with sensitivity analyses conducted to assess potential confounding by pleiotropy, heterogeneity, and the leave-one-out analysis.</p><p><strong>Results: </strong>The statistically driven approach indicates limited evidence of a genetically causal effect of telomere length on the risk of oral cavity cancer (OR = 0.999, 95% CI 0.998-1.000, P = .100), oropharyngeal cancer (OR = 0.999, 95% CI 0.998-1.001, P = .650), combined oral and oropharyngeal cancer (OR = 0.999, 95% CI 0.998-1.000, P = .119) in Europeans. The biologically driven approach demonstrated consistent causal effects across all MR methods, thereby further strengthening the reliability of the results. Moreover, the MR-Egger (Q [df] 170.816 [130], P = .009) and inverse variance weighted methods (Q [df] 171.656 [131], P = .010) identified considerable heterogeneity among instrumental variable estimates in Oral cavity cancer, and no evidence of horizontal pleiotropy was detected.</p><p><strong>Conclusions: </strong>No significant causal associations between telomere length and Oral and oropharyngeal cancers were found in this study.</p>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anterior Endocrowns as An Alternative to Core Crown restorations: A Systematic Review. 前牙内冠作为核心冠修复体的替代方案:系统回顾
IF 3.2 3区 医学
International dental journal Pub Date : 2024-09-20 DOI: 10.1016/j.identj.2024.07.1216
Hisham A Mously, Ghada H Naguib, Ahmed O Abougazia, Afaf A Almabadi, Osama A Qutub, Mohamed T Hamed
{"title":"Anterior Endocrowns as An Alternative to Core Crown restorations: A Systematic Review.","authors":"Hisham A Mously, Ghada H Naguib, Ahmed O Abougazia, Afaf A Almabadi, Osama A Qutub, Mohamed T Hamed","doi":"10.1016/j.identj.2024.07.1216","DOIUrl":"https://doi.org/10.1016/j.identj.2024.07.1216","url":null,"abstract":"<p><p>Restoring extensively damaged endodontically treated teeth presents a challenging task due to the state of biomechanical deterioration affecting long-term prognosis. Therefore, the study aims to assess and compare the biomechanical performance of endocrowns and post core-crown restorations in anterior endodontically treated teeth with severe coronal structure loss. Following PRISMA guidelines, a systematic search was conducted using PubMed, Scopus, Web of Science, and Google Scholar for articles published from January 2014 to March 2024. Two independent reviewers screened and selected studies based on the predefined inclusion and exclusion criteria. The included studies were analyzed using the QUIN tool for risk of bias assessment in in-vitro studies. Additionally, the biomechanical outcomes were collected for qualitative comparative analysis. Twelve studies were included in this systematic review. In most studies, Endocrowns demonstrated comparable fatigue resistance under load to failure to post core-crown restorations. Endocrowns without ferrule exhibited a higher rate of debonding but had significantly more repairable failures. Conversely, post core-crown restorations demonstrated higher fracture resistance with the presence of ferrule, but were associated with more catastrophic failure patterns. Additionally, endocrowns generated lower stress levels in both the restorative material and the luting material compared to post core-crown restorations. Among the tested materials, lithium disilicate ceramics provided the best biomechanical properties. Overall, the studies included provided sufficient information for most evaluation criteria of the QUIN risk of bias assessment tool. Endocrowns are a viable and conservative approach for restoring endodontically treated anterior teeth, offering comparable biomechanical performance to traditional post core-crown restorations and less catastrophic failures. The findings of this systematic review suggest that endocrown restorations, especially with lithium disilicate ceramics and proper ferrule design, can improve fracture resistance and longevity of rehabilitated teeth, enhancing patient outcomes for severely damaged anterior endodontically treated teeth.</p>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary Antioxidant Index and the Risk of Recurrent Aphthous Stomatitis. 膳食抗氧化指数与复发性口腔炎的风险
IF 3.2 3区 医学
International dental journal Pub Date : 2024-09-19 DOI: 10.1016/j.identj.2024.08.003
Golsa Khalatbari Mohseni, Fatemeh Azaryan, Majid Kamali, Aryan Tavakoli, Zahra Mahmoudi, Masoomeh Alsadat Mirshafaei, Khadijeh Abbasi Mobarakeh, Saeideh Mohammadi, Zahra Saeedirad, Masoomeh Ataei Kachooei, Sara Khoshdooz, Saeed Omidi, Saeid Doaei, Maryam Gholamalizadeh
{"title":"Dietary Antioxidant Index and the Risk of Recurrent Aphthous Stomatitis.","authors":"Golsa Khalatbari Mohseni, Fatemeh Azaryan, Majid Kamali, Aryan Tavakoli, Zahra Mahmoudi, Masoomeh Alsadat Mirshafaei, Khadijeh Abbasi Mobarakeh, Saeideh Mohammadi, Zahra Saeedirad, Masoomeh Ataei Kachooei, Sara Khoshdooz, Saeed Omidi, Saeid Doaei, Maryam Gholamalizadeh","doi":"10.1016/j.identj.2024.08.003","DOIUrl":"https://doi.org/10.1016/j.identj.2024.08.003","url":null,"abstract":"<p><strong>Background: </strong>Recurrent aphthous stomatitis (RAS) is a common condition that affects the oral mucosa. Antioxidants are crucial in neutralizing free radicals in the body and may have a preventive role against RAS. This study aims to examine the association between dietary antioxidant index (DAI) and RAS occurrence.</p><p><strong>Methods: </strong>This cross-sectional study was conducted on 144 individuals with RAS and 135 individuals without RAS. The dietary intake of the participants was assessed using the food frequency questionnaire. The DAI was applied to measure the antioxidant capacity of the diet. Logistic regression models were applied to assess the link between RAS and DAI after adjusting the confounding variables.</p><p><strong>Results: </strong>There was a significant negative association between RAS and DAI of zinc (OR = 0.639, CI95%: 0.456-0.896, P = .009) and total score of DAI (OR = 0.802, CI95%: 0.682-0.944, P = .008) after adjustment for age. The results remained significant after further adjustment for body mass index and calorie intake.</p><p><strong>Conclusion: </strong>The present study indicated a possible negative association between the risk of RAS and the DAI score as a measure of the antioxidant potential of diet. Further studies are warranted.</p>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Experimental Bleaching Gels With Enzymes on Composite and Enamel. 含酵素的实验性漂白凝胶对复合材料和珐琅质的影响
IF 3.3 3区 医学
International dental journal Pub Date : 2024-09-12 DOI: 10.1016/j.identj.2024.08.014
Amalia Moldovan,Stanca Cuc,Cristina Gasparik,Codruța Sarosi,Marioara Moldovan,Nicoleta Ilie,Ioan Petean,Laura Monica Rusu,Andrei Ionescu,Mihaela Pastrav
{"title":"Effect of Experimental Bleaching Gels With Enzymes on Composite and Enamel.","authors":"Amalia Moldovan,Stanca Cuc,Cristina Gasparik,Codruța Sarosi,Marioara Moldovan,Nicoleta Ilie,Ioan Petean,Laura Monica Rusu,Andrei Ionescu,Mihaela Pastrav","doi":"10.1016/j.identj.2024.08.014","DOIUrl":"https://doi.org/10.1016/j.identj.2024.08.014","url":null,"abstract":"INTRODUCTION AND AIMSPotential secondary or toxic effects of peroxide-based whitening gels have driven the search for alternative methods that use natural compounds with gentle action on tooth enamel that provide remineralizing benefits.METHODSThis study introduces four innovative experimental whitening gels (GC, G1, G3, G4) formulated with enzymes (Bromelaine and Papaine) and natural extracts, along with SiO2. The efficacy of these gels was tested on nanohybrid dental composite (EsCOM100, Spident Company) and dental enamel stained with coffee and natural juice (Tedi) over 10 days. The structural changes in samples before and after bleaching were examined using scanning electron microscopy and atomic force microscopy. Additionally, cytotoxicity tests were conducted on the gels using mesenchymal stem cells from human dental pulp (dMSC) and human keratinocytes (HaCaT). Antibacterial activity was assessed on five strains (Streptococcus mutans. Porphyromonas gingivalis; Enterococcus faecalis; Escherichia coli; Staphylococcus aureus).RESULTSCoffee and natural juice stains significantly increase the roughness of composite and enamel surfaces by forming deposits. The enzymatic action of bromelain and papain effectively disorganizes and removes these clusters, significantly reducing surface roughness.CONCLUSIONNotably, the gel containing papain and nanostructured SiO2 proved to be the most effective in removing coffee stains from both composite surfaces and enamel. On the other hand, the gel with bromelain and nanostructured SiO2 was the most efficient in removing natural juice stains. The absence of SiO2 in the experimental gels slightly decreased the enzymes' effectiveness in stain removal. The antibacterial activity observed in the experimental gels is attributed solely to the enzymatic compounds.","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142264431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral Health Status and Dental Services Utilisation Among a Vulnerable Sample of Pregnant Women. 弱势孕妇样本的口腔健康状况和牙科服务使用情况。
IF 3.3 3区 医学
International dental journal Pub Date : 2024-09-11 DOI: 10.1016/j.identj.2024.07.009
Yasaman Mohammadi Kamalabadi,M Karen Campbell,Robert Gratton,Abbas Jessani
{"title":"Oral Health Status and Dental Services Utilisation Among a Vulnerable Sample of Pregnant Women.","authors":"Yasaman Mohammadi Kamalabadi,M Karen Campbell,Robert Gratton,Abbas Jessani","doi":"10.1016/j.identj.2024.07.009","DOIUrl":"https://doi.org/10.1016/j.identj.2024.07.009","url":null,"abstract":"INTRODUCTION AND AIMSOral health conditions during pregnancy can negatively impact both mother and fetus, highlighting the importance of maintaining dental care. In Canada, significant disparities exist between general and dental healthcare access, with limited evidence on oral health status and dental care utilisation among pregnant women. This study aimed to provide initial insights into self-perceived oral health status and dental utilisation patterns among a vulnerable sample of pregnant women in southwestern Ontario.METHODSThis cross-sectional study recruited a convenient sample of pregnant women referred to the Family Medicine and Obstetrics Clinic, serving those without a family physician. Data were collected using a self-administered questionnaire adapted from the Canadian Health Measure Survey, the Canadian Community Health Survey, and the Survey of Maternal Health. Andersen and Newman's framework for health service utilisation was used as the theoretical framework. Descriptive and univariable analyses were conducted, followed by a forward stepwise selection of variables with p-values < 0.1 from the univariable analyses.RESULTSOne-hundred-fifty patients were approached and 130 (86.7%) completed the questionnaire. Of these, 96 (73.9%) reported their oral health as good/excellent while 34 (26.2%) reported having poor/fair oral health. Education level and quality of life were the strongest predictors of oral health status. While 101 (77.7%) visited a dentist within the last 2 years, only 35 (26.9%) had a dental visit during pregnancy. Toothbrushing frequency was the main predictor of time since last dental visit, with no other predictive factors once toothbrushing was considered.CONCLUSIONThe study sample showed relatively positive self-perceived oral health and dental visit patterns. However, the low rate of dental visits during pregnancy highlights the need for better integration of dental care into prenatal care. To ensure maternal and child health, pregnant women should be a high priority in policies aimed at improving access to dental care.","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142269369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial Intelligence-Related Dental Research: Bibliometric and Altmetric Analysis. 人工智能相关的牙科研究:文献计量学和 Altmetric 分析。
IF 3.3 3区 医学
International dental journal Pub Date : 2024-09-11 DOI: 10.1016/j.identj.2024.08.004
Wei Lu,Xueqian Yu,Yueyang Li,Yi Cao,Yanning Chen,Fang Hua
{"title":"Artificial Intelligence-Related Dental Research: Bibliometric and Altmetric Analysis.","authors":"Wei Lu,Xueqian Yu,Yueyang Li,Yi Cao,Yanning Chen,Fang Hua","doi":"10.1016/j.identj.2024.08.004","DOIUrl":"https://doi.org/10.1016/j.identj.2024.08.004","url":null,"abstract":"BACKGROUNDRecent years have witnessed an explosive surge in dental research related to artificial intelligence (AI). These applications have optimised dental workflows, demonstrating significant clinical importance. Understanding the current landscape and trends of this topic is crucial for both clinicians and researchers to utilise and advance this technology. However, a comprehensive scientometric study regarding this field had yet to be performed.METHODSA literature search was conducted in the Web of Science Core Collection database to identify eligible \"research articles\" and \"reviews.\" Literature screening and exclusion were performed by 2 investigators. Thereafter, VOSviewer was utilised in co-occurrence analysis and CiteSpace in co-citation analysis. R package Bibliometrix was employed to automatically calculate scientific impacts, determining the core authors and journals. Altmetric data were described narratively and supplemented with Spearman correlation analysis.RESULTSA total of 1558 research publications were included. During the past 5 years, AI-related dental publications drastically increased in number, from 36 to 581. Diagnostics and Scientific Reports published the most articles, whereas Journal of Dental Research received the highest number of citations per article. China, the US, and South Korea emerged as the most prolific countries, whilst Germany received the highest number of citations per article (23.29). Charité Universitätsmedizin Berlin was the institution with the highest number of publications and citations per article (29.16). Altmetric Attention Score was correlated with News Mentions (P < .001), and significant associations were observed amongst Dimension Citations, Mendeley Readers, and Web of Science Citations (P < .001).CONCLUSIONSThe publication numbers regarding AI-related dental research have been rising rapidly and may continue their upwards trend. China, the US, South Korea, and Germany had promoted the progress of AI-related dental research. Disease diagnosis, orthodontic applications, and morphology segmentation were current hotspots. Attention mechanism, explainable AI, multimodal data fusion, and AI-generated text assistants necessitate future research and exploration.","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142269912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Silver Nanoparticles' Size on Biofilm Eradication. 纳米银粒子的大小对生物膜消除的影响
IF 3.3 3区 医学
International dental journal Pub Date : 2024-09-11 DOI: 10.1016/j.identj.2024.08.007
Ghazal Fakeeha,Sarah AlHarbi,Sayed Auda,Hanan Balto
{"title":"The Impact of Silver Nanoparticles' Size on Biofilm Eradication.","authors":"Ghazal Fakeeha,Sarah AlHarbi,Sayed Auda,Hanan Balto","doi":"10.1016/j.identj.2024.08.007","DOIUrl":"https://doi.org/10.1016/j.identj.2024.08.007","url":null,"abstract":"INTRODUCTIONEfficient intracanal disinfection is required for a successful regenerative endodontic treatment. Thus, this study aimed to identify the silver nanoparticles' (NPs) size (AgNPs) with the highest antibiofilm efficacy when mixed with calcium hydroxide [Ca(OH)2] to eradicate an in vitro endodontic biofilm.METHODSThe various sizes of AgNPs and mixtures were characterized by scanning electron microscopy, transmission electron microscopy, and ultraviolet-visible spectroscopy. A total of 168 dentin root segments were prepared, sterilized, and inoculated for 3 weeks with Actinomyces naeslundii and Fusobacterium nucleatum. Samples were randomly allocated to 4 experimental groups (n = 28/group): 2 nm AgNPs + 35% Ca(OH)2, 5 nm AgNPs + 35% Ca(OH)2, 10 nm AgNPs + 35% Ca(OH)2, and 35% Ca(OH)2 alone. Samples exposed to saline and triple antibiotic paste (TAP) acted as negative and positive control groups, respectively. After 1 and 2 weeks, samples were stained with LIVE/DEAD BacLight dye and examined under a confocal laser scanning microscope to determine the proportion of dead bacteria.RESULTSThe characterization procedure revealed a spherical NP's structure with minor aggregations. Except for Ca(OH)2 group, all groups had significantly higher antibiofilm efficacy at 2 weeks. Both the 10 nm mixture (99.5%) and TAP (99.2%) exhibited the highest antibiofilm efficacy at 2 weeks and were not significantly different from one another (P > .05). No significant difference was noted between the 2 and 5 nm mixtures at 1 week (81% and 84%) and 2 weeks (89% and 91%).CONCLUSIONThe 10 nm AgNPs (0.02%) + 35% Ca(OH)2 mixture exhibited the highest antibiofilm efficacy at 2 weeks compared to all other mixtures at both observation periods. Interestingly, the 10 nm mixture performed similarly to TAP at 2 weeks. Excluding Ca(OH)2 group, longer application significantly improved the antibiofilm efficacy of all tested medicaments.CLINICAL RELEVANCEThe 10 nm AgNPs + 35% Ca(OH)2 mixture revealed promising results as an intracanal medicament in the regenerative endodontic treatment protocol.","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142264430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrating Artificial Intelligence in Dental Education: An Urgent Call for Dedicated Postgraduate Programs. 将人工智能融入口腔医学教育:紧急呼吁开设专门的研究生课程。
IF 3.2 3区 医学
International dental journal Pub Date : 2024-09-07 DOI: 10.1016/j.identj.2024.08.008
Mahmood Dashti, Shohreh Ghasemi, Zohaib Khurshid
{"title":"Integrating Artificial Intelligence in Dental Education: An Urgent Call for Dedicated Postgraduate Programs.","authors":"Mahmood Dashti, Shohreh Ghasemi, Zohaib Khurshid","doi":"10.1016/j.identj.2024.08.008","DOIUrl":"https://doi.org/10.1016/j.identj.2024.08.008","url":null,"abstract":"","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acceptability of Allogeneic Mesenchymal Stromal Cell-Based Tissue Engineering for the Treatment of Periodontitis: A Qualitative Study in France. 基于异体间充质基质细胞的组织工程用于治疗牙周炎的可接受性:法国定性研究。
IF 3.2 3区 医学
International dental journal Pub Date : 2024-09-07 DOI: 10.1016/j.identj.2024.07.1208
Lucas Riazuelo, Valérie Planat-Bénard, Alexia Vinel, Sara Laurencin, Louis Casteilla, Philippe Kémoun, Mathieu Marty, Paul Monsarrat
{"title":"Acceptability of Allogeneic Mesenchymal Stromal Cell-Based Tissue Engineering for the Treatment of Periodontitis: A Qualitative Study in France.","authors":"Lucas Riazuelo, Valérie Planat-Bénard, Alexia Vinel, Sara Laurencin, Louis Casteilla, Philippe Kémoun, Mathieu Marty, Paul Monsarrat","doi":"10.1016/j.identj.2024.07.1208","DOIUrl":"https://doi.org/10.1016/j.identj.2024.07.1208","url":null,"abstract":"<p><strong>Introduction and aims: </strong>Periodontitis, the main cause of tooth loss in adults, is a public health concern; its incidence increases with age, and its prevalence increases with increasing life expectancy of the population. Innovative therapies such as cell therapy represent promising future solutions for guided tissue regeneration. However, these therapies may be associated with fears and mistrust from the general public. The aim of this study was to estimate the acceptability of an advanced therapy medicinal product combining allogeneic mesenchymal stromal cells from adipose tissue with a natural fibrin hydrogel in the treatment of periodontitis.</p><p><strong>Methods: </strong>The methodology was based on a qualitative study conducted through semi-structured interviews with patients followed for periodontitis in the Oral Medicine Department of the Toulouse University Hospital, Toulouse, France. Qualitative studies are essential methodologies to understand the patterns of health behaviours, describe illness experiences, and design health interventions in a humanistic and person-centred way of discovering.</p><p><strong>Results: </strong>Eleven interviews (with 4 men and 7 women) were required to reach thematic saturation. Analysis allowed 4 main themes to emerge: (1) perception of new treatments, science, and caregivers; (2) conditions that the treatment must meet; (3) patient perception of the disease; and (4) factors related to the content of the treatment.</p><p><strong>Conclusions: </strong>Patients find cell therapy for periodontitis to be acceptable. If they express a need to be informed about the benefit/risk ratio, they are not particularly worried about side effects of the treatment, for either allogeneic or blood-derived products. Periodontitis is a prototypical model of chronic inflammatory pathology and is multitissular, with hard- and soft-tissue lesions. In a patient-centred approach, the success of cell therapy will require a bilateral, informed decision, taking into account potential therapeutic effectiveness and patient expectations for regeneration.</p>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global Research Trends in the Detection and Diagnosis of Dental Caries: A Bibliometric Analysis. 龋齿检测和诊断的全球研究趋势:文献计量分析
IF 3.2 3区 医学
International dental journal Pub Date : 2024-09-04 DOI: 10.1016/j.identj.2024.08.010
Jane Ching-Lam Lui, Walter Yu-Hang Lam, Chun-Hung Chu, Ollie Yiru Yu
{"title":"Global Research Trends in the Detection and Diagnosis of Dental Caries: A Bibliometric Analysis.","authors":"Jane Ching-Lam Lui, Walter Yu-Hang Lam, Chun-Hung Chu, Ollie Yiru Yu","doi":"10.1016/j.identj.2024.08.010","DOIUrl":"https://doi.org/10.1016/j.identj.2024.08.010","url":null,"abstract":"<p><p>This study aims to provide an overview of the global research trends in the detection and diagnosis of dental caries in the past 20 years. A literature search was conducted in the Scopus Database to retrieve studies on the diagnostic approaches for dental caries published from January 2003 to December 2023. The diagnostic approaches in the retrieved studies were examined and the studies were categorized according to the diagnostic approaches investigated. Bibliometric data including journals, countries, affiliations, authors, and numbers of citations of the publications were summarised. The publications' keyword co-occurrence was analysed using VOSviewer. This bibliometric analysis included 1879 publications investigating seven categories of caries diagnostic approaches, including visual and/or tactile (n = 459; 19%), radiation-based (n = 662; 27%), light-based (n = 771; 32%), ultrasound-based (n = 28; 1%), electric-based (n = 51; 2%), molecular-based (n = 196; 8%) diagnostic approaches, as well as AI-based diagnostic interpretation aids (n = 265; 11%). An increase in the annual number of publications on caries diagnostic approaches was observed in the past 20 years. Caries Research (n = 103) presented the highest number of publications on caries diagnostic approaches. The country with the highest number of publications was the United States (n = 1092). The University of São Paulo was the institution that published the highest number of articles (n = 195). The publication with the highest citation has been cited 932 times. VOS viewer revealed that the most frequently occurring keywords were 'Deep Learning', 'Artificial Intelligence', 'Laser Fluorescence' and 'Radiography'. This bibliometric analysis highlighted an emerging global research trend in the detection and diagnosis approaches for dental caries in the past 20 years. An evident increase in publications on molecular-based caries diagnostic approaches and AI-based diagnostic interpretation aids was perceived over the last 5 years.</p>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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