International dental journal最新文献

{"title":"Making the Right to Oral Health a Reality for Older Adults","authors":"Kakuhiro Fukai, Sophie Dartevelle, Judith Jones, Gerry McKenna, Hirohiko Hirano, FDI World Dental FederationAll authors are member of FDI's Oral Health for an Ageing Population Task Team","doi":"10.1016/j.identj.2025.02.010","DOIUrl":"10.1016/j.identj.2025.02.010","url":null,"abstract":"","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 3","pages":"Pages 1732-1735"},"PeriodicalIF":3.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Somatic Symptoms as Idioms of Distress in East Asian Patients With Differing Temporomandibular Disorder Diagnostic Subtypes","authors":"Adrian Ujin Yap ,&nbsp;Sunghae Kim ,&nbsp;Jung Hwan Jo ,&nbsp;Byeong-min Lee ,&nbsp;Ji Woon Park","doi":"10.1016/j.identj.2025.03.010","DOIUrl":"10.1016/j.identj.2025.03.010","url":null,"abstract":"<div><h3>Objective</h3><div>This cross-sectional study investigated the prevalence/severity of somatic symptoms, their relationship with psychological distress and oral behaviors in different temporomandibular disorder (TMD) diagnostic subtypes, and identified biopsychosocial factors associated with depression, anxiety, and jaw overuse behavior among East Asian patients.</div></div><div><h3>Methods</h3><div>Anonymized data from consecutive new TMD patients at a tertiary oral medicine clinic were evaluated. TMD diagnoses were determined using the DC/TMD methodology, while somatic symptoms, depression, anxiety, and oral behaviors were assessed with the Patient Health Questionnaire (PHQ)-15, PHQ-9, Generalized Anxiety Disorder Scale-7, and Oral Behavior Checklist. Data were examined using the Chi-square/non-parametric tests and multivariate linear regression analysis (α = 0.05).</div></div><div><h3>Results</h3><div>Among the 699 patients, somatic symptoms were present in 36.8%, 54.0%, and 48.2% of individuals with intra-articular (IT), pain-related (PT), and combined (CT) TMDs respectively. Significant differences in somatic symptom burden/depression (PT, CT &gt; IT) and anxiety (CT &gt; IT) were observed. For all TMD subtypes, patients with somatic symptoms showed significantly greater depression, anxiety, and jaw overuse behavior compared to those without somatic symptoms. Somatic symptoms were moderately correlated with depression and anxiety (<em>r_s</em> = 0.51-0.65).</div></div><div><h3>Conclusion</h3><div>Somatic symptom burden was linked to depression and anxiety, supporting the phenomenon of somatization across different TMD subtypes.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 3","pages":"Pages 1713-1721"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circ_0003072 Mediates the Pro-osteogenic Differentiation Effect of Betulinic Acid on Human Periodontal Ligament Stem Cells.","authors":"Yuesun Qi, Chunnan Lin, Chengwei Zhao, Ye Wu","doi":"10.1016/j.identj.2024.10.017","DOIUrl":"10.1016/j.identj.2024.10.017","url":null,"abstract":"<p><strong>Background: </strong>Betulinic acid (BetA) exhibits a good pro-osteogenic differentiation effect on human periodontal ligament stem cells (hPDLSCs), making it a promising supplement for periodontal regeneration. Circular RNAs (circRNAs) have emerged as important regulators of cellular behaviour, and whether circRNAs are involved in the effects of BetA remains unknown.</p><p><strong>Methods: </strong>Bioinformatics analysis was used to screen for dysregulated circRNAs involved in osteogenic differentiation based on public datasets. Osteogenic differentiation was evaluated using quantitative PCR detection of RUNX2, ALPL, COL1A1, and BGLAP levels, alkaline phosphatase staining, and Alizarin Red S staining of calcified nodules. The role of circ_0003072 in the BetA-regulated osteogenic differentiation of hPDLSCs was investigated, and its downstream microRNAs and mRNA were confirmed using RNA-sequencing, competing endogenous RNA network construction, gene ontology analysis, dual-luciferase reporter assays, and functional assays.</p><p><strong>Results: </strong>circ_0003072 showed the highest fold-change among the 18 candidate circRNAs, and knockdown of circ_0003072 inhibited the pro-osteogenic differentiation effect of BetA on hPDLSCs. RNA-sequencing combined with gene ontology analysis identified 11 osteogenesis-relevant genes. Five genes that shared microRNAs between circ_0003072 and two candidate genes (chordin-like 1 [CHRDL1] and XIAP) were screened, and miR-488-3p showed the highest increase after silencing circ_0003072. Knockdown of circ_0003072 inhibited the pro-osteogenic differentiation effect of silencing miR-488-3p. miR-488-3p bound to circ_0003072 and CHRDL1. Furthermore, overexpression of CHRDL1 rescued the miR-488-3p-induced inhibition of osteogenic differentiation.</p><p><strong>Conclusion: </strong>BetA promoted the osteogenic differentiation of hPDLSCs by regulating the circ_0003072/miR-488-3p/CHRDL1 pathway, and circ_0003072 acted as a sponge for miR-488-3p, thus upregulating the level of CHRDL1.</p>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":"1390-1399"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Electronic Cigarettes on Oral Microbiome and Metabolome in 3D Tissue-Engineered Models: Comment.","authors":"Amnuay Kleebayoon, Viroj Wiwanitkit","doi":"10.1016/j.identj.2025.01.004","DOIUrl":"10.1016/j.identj.2025.01.004","url":null,"abstract":"","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":"1450-1451"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron Status and Risk of Periodontitis and Dental Caries: A Mendelian Randomization Study.","authors":"Jiaqi Wu, Ziyang Zheng, Jinghan Wang, Weiwei Xiao, Liang Shi, Liyuan Fan","doi":"10.1016/j.identj.2024.11.018","DOIUrl":"10.1016/j.identj.2024.11.018","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have indicated a potential relationship between iron status and oral health outcomes, specifically periodontitis and dental caries. This study employed Mendelian randomization (MR) to investigate the causal effects of iron status on these oral health conditions. The focus of this study was on key iron biomarkers, namely serum iron, ferritin, transferrin saturation (TSAT), and total iron-binding capacity (TIBC).</p><p><strong>Methods: </strong>This two-sample MR analysis employed genome-wide association study (GWAS) data. The instrumental variables (IVs) were selected based on their genome-wide significance and independence from confounders. The statistical analyses employed the inverse variance weighted (IVW) method, MR-Egger regression, weighted median, and weighted mode. Additionally, sensitivity analyses were conducted to verify the reliability of the causal association results.</p><p><strong>Results: </strong>The MR analysis indicated a suggestive negative causal relationship between TIBC and periodontitis, with an odds ratios of 0.875 and a 95% CI of 0.766-0.998, with a P-value of .047. No significant other associations were found. The results of sensitivity analyses demonstrated the robustness of these findings.</p><p><strong>Conclusion: </strong>This MR study suggested a potential negative association between TIBC and periodontitis, highlighting the importance of considering iron status in the clinical management of chronic periodontitis. However, more standardized, multi-population studies are needed to confirm this causality.</p>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":"1441-1449"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteogenic Induction Activity of Magnesium Chloride on Human Periodontal Ligament Stem Cells.","authors":"Supanat Lumbikananda, Kittiphoj Tikkhanarak, Sarai Pongjantarasatian, Vorapat Trachoo, Worachat Namangkalakul, Thanaphum Osathanon","doi":"10.1016/j.identj.2024.11.013","DOIUrl":"10.1016/j.identj.2024.11.013","url":null,"abstract":"<p><strong>Objectives: </strong>Periodontal ligament stem cells (PDLSCs) are promising for regenerative therapies due to their self-renewal and multilineage differentiation, essential for periodontal tissue repair. Although magnesium plays a vital role in bone metabolism, its specific effects on PDLSCs and potential applications in regeneration are unclear. This study aimed to investigate the effects of magnesium chloride (MgCl₂) on the proliferation and osteogenic differentiation of human PDLSCs (hPDLSCs).</p><p><strong>Methods: </strong>hPDLSCs were isolated, characterised, and treated with 0.1-40 mM MgCl₂. Cell viability and proliferation were assessed using an MTT assay. Cell migration was measured by a scratch assay. Colony-forming unit formation and cell cycle analysis were examined using crystal violet and propidium iodide staining. Osteogenic differentiation was assessed through alkaline phosphatase activity, Alizarin Red S staining, and RT-qPCR for osteogenic-related gene expression. RNA sequencing was performed to evaluate differential gene expression patterns in hPDLSCs treated with 10 mM MgCl₂. All statistical analyses were evaluated at P < .05.</p><p><strong>Results: </strong>hPDLSCs exhibited mesenchymal stem cell characteristics. MgCl₂ concentrations higher than 10 mM were cytotoxic. Significant increases in cell proliferation, colony-forming unit percentages, and active cell cycle activity were observed when treated with 0.1, 0.5, and 1 mM MgCl₂. However, MgCl₂ had no effect on cell migration. Mineralised nodule formation was observed in hPDLSCs treated with 0.1 and 0.5 mM MgCl₂ in osteogenic induction media, mediated by TRPM7 cation channel, along with upregulated expression of osteogenic marker genes. Bioinformatic analysis indicated alterations in chemokine signalling and cellular calcium homeostasis pathways when treated with 10 mM MgCl₂.</p><p><strong>Conclusions: </strong>MgCl₂ at a dose of 0.1 mM is the most effective concentration to promote cell proliferation and stimulate osteogenic differentiation of hPDLSCs in vitro. These findings indicate that MgCl₂ enhances both the proliferation and osteogenic differentiation of hPDLSCs, supporting its potential application in periodontal tissues and alveolar bone regeneration.</p>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":"1431-1440"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Numbering System for Teeth Following Hemisection, Bicuspidisation, and Root Resection.","authors":"Manali Ramakrishnan Srinivasan, Saravanan Poorni, Liran Levin, Paul Mh Dummer, Venkateshbabu Nagendrababu","doi":"10.1016/j.identj.2024.12.028","DOIUrl":"10.1016/j.identj.2024.12.028","url":null,"abstract":"","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":"1452-1454"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to 'COVID-19 severity in patients with apical periodontitis: a case control study' [International Dental Journal, 74/4 (2024), 736-745].","authors":"Nadya Marouf, Raidan Ba-Hattab, Fatima Al-Sheeb, Amal Diab, Hanan Diab, Maryam Al-Majed, Khalid Al-Haithami, Ghanim Al-Mannai, Noha Barhom, Shailaja Tharupeedikayil, Sok-Ja Janket, Faleh Tamimi","doi":"10.1016/j.identj.2024.12.021","DOIUrl":"10.1016/j.identj.2024.12.021","url":null,"abstract":"","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":"1459"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Information on Dutch Dental Practice Websites Regarding the Treatment of (Frail) Elderly Patients.","authors":"Johanna Margaretha Kroese, Brigitta Yue Zhi Li, Samuel Julian The, Jan Joseph Mathieu Bruers","doi":"10.1016/j.identj.2024.10.023","DOIUrl":"10.1016/j.identj.2024.10.023","url":null,"abstract":"<p><p>The number of elderly people worldwide and their need for dental care increases in a yearly basis. A dental practice website can be a valuable source of information to these patients that may need comprehensive or adjusted care. Therefore, this study aimed to evaluate the information on Dutch general dental practice websites on topics relevant to the treatment of (frail) elderly patients. Websites were selected from (1) a random sample of 217 Dutch general dental practices (sample-group) and (2) dental practices of 130 members of the Dutch Association for Gerodontology (gero-group), and screened for items in 4 categories: website functionality, contact details and accessibility, composition of the dental team, and specific information for elderly patients. Of the selected websites, 196 in the sample-group and 54 in the gero-group were eligible for data collection. Most websites mentioned opening hours, a phone number, and the composition of the dental team. Other information was overall scarce, especially regarding (frail) elderly patients. The gero-group significantly more often mentioned elderly as a specific target patient group (11,1% vs 2,6%), but numbers were overall low. Websites in the gero-group were hardly more informative or adjusted to elderly than in the sample-group; wheelchair accessibility was the only feature mentioned significantly more often (37.0% vs 17.3%). Only one website in the sample-group and 2 websites in the gero-group mentioned the possibility of home visits. In conclusion, dental practice websites lack information in general, and information relevant to elderly patients in particular, and there is room for improvement in website functionality. Additionally, general dental practices seem insufficiently equipped for the treatment of (frail) elderly patients, highlighting the need for improvement of oral healthcare for this specific patient group. This study addresses the insufficiencies in the provision of information on dental practice websites, allowing for targeted future studies towards improvement.</p>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":"1384-1389"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of a Local Drug Delivery System Based on Antimicrobial Peptides in Early Treatment of Peri-implantitis.","authors":"Xiling Liu, Lan Liu, Zheng Zeng","doi":"10.1016/j.identj.2024.11.001","DOIUrl":"10.1016/j.identj.2024.11.001","url":null,"abstract":"<p><strong>Objective: </strong>To analyse the effects of titanium implants coated with various antimicrobial peptide (AMP) layers on bacterial growth and early biofilm formation around the implants.</p><p><strong>Methods: </strong>A novel AMP mixture was constructed using Type I collagen, sulfonated succinimide 4- (N-Maleimidylphenyl) butyrate, and AMPs. Titanium discs treated with chitosan and hyaluronic acid solutions were reacted with the AMP mixture to obtain AMP-coated titanium discs. The drug release properties and inhibitory effects on the growth and early biofilm formation of Porphyromonasgingivalis (P. gingivalis) ATCC BAA-308 or Staphylococcus aureus (S. aureus) ATCC 25923 were analysed.</p><p><strong>Results: </strong>The antimicrobial activity of the 9-layer AMP-coated titanium discs against P. gingivalis ATCC BAA-308 and S.aureus ATCC 25923 was greatly higher relative to the 3-layer and 6-layer AMP-coated titanium discs (P < .05). The overall optical density and average optical density of titanium discs coated with 6 and 9 layers of AMPs were markedly inferior to those of uncoated titanium discs and discs coated with 3 layers of AMPs (P < .05). The drug release amounts from titanium discs coated with different layers of AMPs increased over time.</p><p><strong>Conclusions: </strong>The prepared AMP-coated titanium discs effectively inhibit the growth of P. gingivalis and S. aureus, as well as early biofilm formation. The drug-laced discs demonstrate good durability and predictability in drug release, which may be beneficial for long-term therapeutic adoption.</p>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":"1400-1408"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}