International dental journal最新文献

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New Numbering System for Teeth Following Hemisection, Bicuspidisation, and Root Resection.
IF 3.2 3区 医学
International dental journal Pub Date : 2025-04-01 Epub Date: 2025-01-24 DOI: 10.1016/j.identj.2024.12.028
Manali Ramakrishnan Srinivasan, Saravanan Poorni, Liran Levin, Paul Mh Dummer, Venkateshbabu Nagendrababu
{"title":"New Numbering System for Teeth Following Hemisection, Bicuspidisation, and Root Resection.","authors":"Manali Ramakrishnan Srinivasan, Saravanan Poorni, Liran Levin, Paul Mh Dummer, Venkateshbabu Nagendrababu","doi":"10.1016/j.identj.2024.12.028","DOIUrl":"10.1016/j.identj.2024.12.028","url":null,"abstract":"","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":"1452-1454"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to 'COVID-19 severity in patients with apical periodontitis: a case control study' [International Dental Journal, 74/4 (2024), 736-745]. “根尖牙周炎患者COVID-19严重程度的病例对照研究”[国际牙科杂志,74/4(2024),736-745]。
IF 3.2 3区 医学
International dental journal Pub Date : 2025-04-01 Epub Date: 2025-01-02 DOI: 10.1016/j.identj.2024.12.021
Nadya Marouf, Raidan Ba-Hattab, Fatima Al-Sheeb, Amal Diab, Hanan Diab, Maryam Al-Majed, Khalid Al-Haithami, Ghanim Al-Mannai, Noha Barhom, Shailaja Tharupeedikayil, Sok-Ja Janket, Faleh Tamimi
{"title":"Corrigendum to 'COVID-19 severity in patients with apical periodontitis: a case control study' [International Dental Journal, 74/4 (2024), 736-745].","authors":"Nadya Marouf, Raidan Ba-Hattab, Fatima Al-Sheeb, Amal Diab, Hanan Diab, Maryam Al-Majed, Khalid Al-Haithami, Ghanim Al-Mannai, Noha Barhom, Shailaja Tharupeedikayil, Sok-Ja Janket, Faleh Tamimi","doi":"10.1016/j.identj.2024.12.021","DOIUrl":"10.1016/j.identj.2024.12.021","url":null,"abstract":"","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":"1459"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the Information on Dutch Dental Practice Websites Regarding the Treatment of (Frail) Elderly Patients. 荷兰牙科诊所网站对(体弱)老年患者治疗信息的评价。
IF 3.2 3区 医学
International dental journal Pub Date : 2025-04-01 Epub Date: 2024-12-16 DOI: 10.1016/j.identj.2024.10.023
Johanna Margaretha Kroese, Brigitta Yue Zhi Li, Samuel Julian The, Jan Joseph Mathieu Bruers
{"title":"Evaluation of the Information on Dutch Dental Practice Websites Regarding the Treatment of (Frail) Elderly Patients.","authors":"Johanna Margaretha Kroese, Brigitta Yue Zhi Li, Samuel Julian The, Jan Joseph Mathieu Bruers","doi":"10.1016/j.identj.2024.10.023","DOIUrl":"10.1016/j.identj.2024.10.023","url":null,"abstract":"<p><p>The number of elderly people worldwide and their need for dental care increases in a yearly basis. A dental practice website can be a valuable source of information to these patients that may need comprehensive or adjusted care. Therefore, this study aimed to evaluate the information on Dutch general dental practice websites on topics relevant to the treatment of (frail) elderly patients. Websites were selected from (1) a random sample of 217 Dutch general dental practices (sample-group) and (2) dental practices of 130 members of the Dutch Association for Gerodontology (gero-group), and screened for items in 4 categories: website functionality, contact details and accessibility, composition of the dental team, and specific information for elderly patients. Of the selected websites, 196 in the sample-group and 54 in the gero-group were eligible for data collection. Most websites mentioned opening hours, a phone number, and the composition of the dental team. Other information was overall scarce, especially regarding (frail) elderly patients. The gero-group significantly more often mentioned elderly as a specific target patient group (11,1% vs 2,6%), but numbers were overall low. Websites in the gero-group were hardly more informative or adjusted to elderly than in the sample-group; wheelchair accessibility was the only feature mentioned significantly more often (37.0% vs 17.3%). Only one website in the sample-group and 2 websites in the gero-group mentioned the possibility of home visits. In conclusion, dental practice websites lack information in general, and information relevant to elderly patients in particular, and there is room for improvement in website functionality. Additionally, general dental practices seem insufficiently equipped for the treatment of (frail) elderly patients, highlighting the need for improvement of oral healthcare for this specific patient group. This study addresses the insufficiencies in the provision of information on dental practice websites, allowing for targeted future studies towards improvement.</p>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":"1384-1389"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of a Local Drug Delivery System Based on Antimicrobial Peptides in Early Treatment of Peri-implantitis. 基于抗菌肽的局部给药系统在种植体周围炎早期治疗中的有效性。
IF 3.2 3区 医学
International dental journal Pub Date : 2025-04-01 Epub Date: 2024-11-30 DOI: 10.1016/j.identj.2024.11.001
Xiling Liu, Lan Liu, Zheng Zeng
{"title":"Effectiveness of a Local Drug Delivery System Based on Antimicrobial Peptides in Early Treatment of Peri-implantitis.","authors":"Xiling Liu, Lan Liu, Zheng Zeng","doi":"10.1016/j.identj.2024.11.001","DOIUrl":"10.1016/j.identj.2024.11.001","url":null,"abstract":"<p><strong>Objective: </strong>To analyse the effects of titanium implants coated with various antimicrobial peptide (AMP) layers on bacterial growth and early biofilm formation around the implants.</p><p><strong>Methods: </strong>A novel AMP mixture was constructed using Type I collagen, sulfonated succinimide 4- (N-Maleimidylphenyl) butyrate, and AMPs. Titanium discs treated with chitosan and hyaluronic acid solutions were reacted with the AMP mixture to obtain AMP-coated titanium discs. The drug release properties and inhibitory effects on the growth and early biofilm formation of Porphyromonasgingivalis (P. gingivalis) ATCC BAA-308 or Staphylococcus aureus (S. aureus) ATCC 25923 were analysed.</p><p><strong>Results: </strong>The antimicrobial activity of the 9-layer AMP-coated titanium discs against P. gingivalis ATCC BAA-308 and S.aureus ATCC 25923 was greatly higher relative to the 3-layer and 6-layer AMP-coated titanium discs (P < .05). The overall optical density and average optical density of titanium discs coated with 6 and 9 layers of AMPs were markedly inferior to those of uncoated titanium discs and discs coated with 3 layers of AMPs (P < .05). The drug release amounts from titanium discs coated with different layers of AMPs increased over time.</p><p><strong>Conclusions: </strong>The prepared AMP-coated titanium discs effectively inhibit the growth of P. gingivalis and S. aureus, as well as early biofilm formation. The drug-laced discs demonstrate good durability and predictability in drug release, which may be beneficial for long-term therapeutic adoption.</p>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":"1400-1408"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Colour Changes and Surface Roughness After Air-Polishing for Tobacco Stain Removal. 烟草污渍空气抛光后的颜色变化和表面粗糙度。
IF 3.2 3区 医学
International dental journal Pub Date : 2025-04-01 Epub Date: 2024-12-20 DOI: 10.1016/j.identj.2024.11.008
Lukas Sigwart, Vera Wiesmüller, Ines Kapferer-Seebacher
{"title":"Colour Changes and Surface Roughness After Air-Polishing for Tobacco Stain Removal.","authors":"Lukas Sigwart, Vera Wiesmüller, Ines Kapferer-Seebacher","doi":"10.1016/j.identj.2024.11.008","DOIUrl":"10.1016/j.identj.2024.11.008","url":null,"abstract":"<p><strong>Introduction and aims: </strong>We aimed to investigate the efficacy of air-polishing in restoring the original tooth colour of standardised tobacco-stained tooth specimens.</p><p><strong>Methods: </strong>Seventy-two specimens consisting of half dentine and half enamel were daily exposed to the smoke of five cigarettes in an automated smoking chamber. Four repetitions of a 14-day smoking cycle were performed. Specimens were cleaned after each cycle, either by air-polishing with erythritol or sodium bicarbonate powder, or with a rubber cup and pumice stone as control. Spectral photometric colour changes (ΔE) and profilometric surface roughness were measured before and after each cycle. All samples were stored for the entirety of the study period in artificial saliva to mimic oral conditions and to establish a pellicle layer on the samples.</p><p><strong>Results: </strong>The tested cleaning procedures effectively removed tobacco staining from dentine and enamel samples, however, none of the treatments could restore the original colour. Mean [SD] tooth colour of enamel specimens after four cycles was not statistically significantly different between erythritol (E = 77.6 [6.6]) and sodium bicarbonate air-polishing (E = 79.8 [7.0]) (P > .05). ΔE showed no significant differences between the air-polishing groups after four cycles (P > .05) but with the control group (P < .001). On dentine there was no statistically significant difference of ΔE between all three groups (P > .05). No significant differences in enamel and dentine roughness compared to baseline were observed after repeated air-polishing with erythritol (P > .05).</p><p><strong>Conclusions: </strong>Erythritol air-polishing removed smoker's discolourations just as effectively as air-polishing with sodium bicarbonate and polishing with pumice, without altering the roughness of the tooth structures. Tobacco stains do not reoccur faster or stronger after the use of air-polishing devices than after polishing with rubber cup and paste.</p><p><strong>Clinical relevance: </strong>Air-polishing with erythritol emerged as a safe and efficient option for removing extrinsic tooth discolourations with the least abrasive character. These findings support the clinical relevance of incorporating air-polishing devices, particularly with erythritol powder, in dental practice for managing tobacco-induced tooth discolourations.</p>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":"1409-1419"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Pyrroloquinazoline Analogue Regulated Streptococcus mutans and Streptococcus sanguinis Dual-Species Biofilms. 吡咯喹啉类似物调控变形链球菌和血链球菌双种生物膜。
IF 3.2 3区 医学
International dental journal Pub Date : 2025-04-01 Epub Date: 2025-01-09 DOI: 10.1016/j.identj.2024.11.010
Keke Zhang, Mengjia Gao, Gaozhe Zheng, Puxin Xu, Yu Fu, Lili Qiu, Fangzheng Yu, Yan Shen, Min Wang, Xiangyu Hu, Yan Sun, Lingjun Zhang, Yihuai Pan
{"title":"A Pyrroloquinazoline Analogue Regulated Streptococcus mutans and Streptococcus sanguinis Dual-Species Biofilms.","authors":"Keke Zhang, Mengjia Gao, Gaozhe Zheng, Puxin Xu, Yu Fu, Lili Qiu, Fangzheng Yu, Yan Shen, Min Wang, Xiangyu Hu, Yan Sun, Lingjun Zhang, Yihuai Pan","doi":"10.1016/j.identj.2024.11.010","DOIUrl":"10.1016/j.identj.2024.11.010","url":null,"abstract":"<p><strong>Objective: </strong>Selective inhibition of cariogenic bacteria is regarded as a potential strategy against caries. To assess the potential of SCH-79797, one novel promising antibiotic, in microbial equilibrium using a dual-species biofilms model of Streptococcus mutans (S. mutans) and Streptococcus sanguinis (S. sanguinis).</p><p><strong>Methods: </strong>Biofilm biomass and metabolic activity were disclosed using the MTT and crystal violet staining methods. Besides, bacteria/exopolysaccharide staining and anthrone method were applied to measure extracellular polysaccharides (EPS) synthesis, while lactic acid measurement was used to assess acid production. Then, quantitative real-time PCR (qRT-PCR) was employed to investigate gene variation related to polysaccharide production and interspecies competition within dual-species biofilm. The dual-species biofilm configuration was mirrored by fluorescence in situ hybridization (FISH). Growth of the planktonic bacteria was reflected by growth curve. Lastly, bacterial cell membranes were visualized by transmission electron microscope (TEM).</p><p><strong>Results: </strong>Within dual-species biofilm, SCH-79797 not only abated biomass, metabolic activity, EPS as well as acid generation but also decreased the proportion of opportunistic cariogenic S. mutans. Besides, polysaccharides production and competition-related genes (gtfP, spxB) in S. sanguinis were up-regulated, whereas these associated genes (gtfB, gtfC, gtfD, and nlmD) in S. mutans were down-regulated inside dual-species biofilm which displayed decreased S. mutans ratio. Additionally, SCH-79797 had a selective inhibitory effect on S. mutans rather than S. sanguinis, including biofilm's biomass, metabolic activity, acid and polysaccharides generation, bacterial growth, and cell membrane integrity.</p><p><strong>Conclusions: </strong>SCH-79797 showed regulatory effects on controlling dual-species biofilm ecologically, indicating its potential to be a latent anticaries agent.</p>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":"1420-1430"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142964524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary Flavonoid Intake and Periodontitis.
IF 3.2 3区 医学
International dental journal Pub Date : 2025-04-01 Epub Date: 2025-01-24 DOI: 10.1016/j.identj.2024.12.016
Hinpetch Daungsupawong, Viroj Wiwanitkit
{"title":"Dietary Flavonoid Intake and Periodontitis.","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.1016/j.identj.2024.12.016","DOIUrl":"10.1016/j.identj.2024.12.016","url":null,"abstract":"","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":"1455"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stakeholders’ Perspectives on Quality Measurement of Oral Health Care in the Netherlands: A Qualitative Study
IF 3.2 3区 医学
International dental journal Pub Date : 2025-04-01 DOI: 10.1016/j.identj.2025.03.004
Amy Righolt , Denise Duijster , Kirsten Smits , Anke Oerlemans , Philip van der Wees , Stefan Listl
{"title":"Stakeholders’ Perspectives on Quality Measurement of Oral Health Care in the Netherlands: A Qualitative Study","authors":"Amy Righolt ,&nbsp;Denise Duijster ,&nbsp;Kirsten Smits ,&nbsp;Anke Oerlemans ,&nbsp;Philip van der Wees ,&nbsp;Stefan Listl","doi":"10.1016/j.identj.2025.03.004","DOIUrl":"10.1016/j.identj.2025.03.004","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to identify which barriers and facilitators exist and can be expected when measuring quality of oral health care according to different stakeholders in the Netherlands.</div></div><div><h3>Methods</h3><div>A total of 36 semistructured interviews were conducted with dentists, patients, universities and knowledge institutes, health insurance companies, professional dental associations, and governmental health organisations. Using qualitative content analysis, barriers and facilitators were classified according to the frameworks of Grol and Cabana.</div></div><div><h3>Results</h3><div>In total 70 barrier and 53 facilitating factors were identified in the 5 domains of the frameworks. Various stakeholders found quality measurement challenging because the quality of oral health care is difficult to define with a lack of consensus on what constitutes quality of oral health care. Patients mentioned that, for them, quality of oral health care is difficult to assess. Dentists experienced a fear of being monitored and were apprehensive of the administrative burden of quality measurement. On an organisational level, the isolation of dentistry from the medical field was mentioned as a barrier. Facilitating factors were discussing quality in a trusted environment, and developing more clinical practice guidelines, which include meaningful quality measures.</div></div><div><h3>Discussion</h3><div>This study identified barriers and facilitators for measuring quality of oral health care in the Netherlands. Findings signal the importance of achieving consensus on the definition of quality of oral health care. Further strategy discussions about how quality of oral health care can be made insightful in a way acceptable to all stakeholders are needed to make progressions in quality improvement.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 3","pages":"Pages 1722-1731"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Virtual Articulator Software: Accuracy, Usability, and Clinical Applicability: A Systematic Review
IF 3.2 3区 医学
International dental journal Pub Date : 2025-03-31 DOI: 10.1016/j.identj.2025.03.005
Ravinder S. Saini PhD , Hatim Hashim Alshoail , Masroor Ahmed Kanji , Sunil Kumar Vaddamanu , Seyed Ali Mosaddad , Artak Heboyan
{"title":"Virtual Articulator Software: Accuracy, Usability, and Clinical Applicability: A Systematic Review","authors":"Ravinder S. Saini PhD ,&nbsp;Hatim Hashim Alshoail ,&nbsp;Masroor Ahmed Kanji ,&nbsp;Sunil Kumar Vaddamanu ,&nbsp;Seyed Ali Mosaddad ,&nbsp;Artak Heboyan","doi":"10.1016/j.identj.2025.03.005","DOIUrl":"10.1016/j.identj.2025.03.005","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>Virtual articulator software platforms have gained popularity in dentistry for simulating dental articulations, but a comprehensive comparison of their accuracy, user-friendliness, and clinical relevance is lacking. This study aimed to evaluate various virtual articulator software platforms, focusing on accuracy, user-friendliness, and clinical applicability.</div></div><div><h3>Methods</h3><div>A systematic search was conducted across PubMed, Google Scholar, ScienceDirect, the Cochrane Library, and Scopus, following the PICO/PEO strategy for inclusion and exclusion criteria. Studies comparing virtual articulator software platforms up to 2023 were included. Eligible studies were selected, and relevant data were extracted. The quality of the research was assessed using the QUIN tool for in vitro studies and the Mixed Methods Appraisal Tool (MMAT) tool for non-in vitro studies. Likewise, for the certainty of evidence, the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) framework was utilized.</div></div><div><h3>Results</h3><div>Out of 3,091 initially identified research articles, 17 met the inclusion criteria. The analysis revealed a diverse range of virtual articulator systems, including Panadent, Ortho CAD™, CT, CAD/CAM, PAN 300, and MATLAB program, serving as alternatives to traditional articulators. The virtual articulator software demonstrated efficiency and user-friendliness, highlighting their potential in dental applications.</div></div><div><h3>Conclusion</h3><div>The diversity of software, platforms, and systems for virtual articulators prevents the formulation of definitive and succinct conclusions. Nevertheless, in a general assessment, virtual articulators demonstrated comparable accuracy and precision when juxtaposed with their traditional counterparts.</div></div><div><h3>Clinical Relevance</h3><div>Virtual articulator software accurately simulates occlusal relationships and mandibular movements, enhancing dental treatment planning and patient outcomes. These tools integrate easily into clinical workflows, improving communication and personalized care. While further research is needed to standardize assessment methods, virtual articulators show comparable precision to traditional methods, supporting their use in diverse clinical scenarios.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 3","pages":"Pages 1691-1704"},"PeriodicalIF":3.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of Adverse Events Associated With Dental Local Anaesthetics Using Food and Drug Administration Adverse Event Reporting System Data
IF 3.2 3区 医学
International dental journal Pub Date : 2025-03-31 DOI: 10.1016/j.identj.2025.03.002
Ferit Bayram , Ahmet Akici , Asli Melda Apari , Volkan Aydin
{"title":"Analysis of Adverse Events Associated With Dental Local Anaesthetics Using Food and Drug Administration Adverse Event Reporting System Data","authors":"Ferit Bayram ,&nbsp;Ahmet Akici ,&nbsp;Asli Melda Apari ,&nbsp;Volkan Aydin","doi":"10.1016/j.identj.2025.03.002","DOIUrl":"10.1016/j.identj.2025.03.002","url":null,"abstract":"<div><h3>Objective</h3><div>Local anaesthetics (LAs), almost indispensable aspect of dental practice for pain-free procedures, occasionally leads to worrisome adverse events (AEs). We aimed to compare serious and nonserious AEs of LAs for dental reasons in the US Food and Drug Administration AE Reporting System.</div></div><div><h3>Methods</h3><div>We retrospectively analysed dental AE reports associated with LAs in the Food and Drug Administration AE Reporting System database from its inception to April 2024. We described AEs by patients’ demographic and clinical characteristics and compared ester and amide LA-associated AEs by their severity.</div></div><div><h3>Results</h3><div>We identified 1956 dental cases with a significant increase of AE reports after 2017. Lidocaine and articaine were the most commonly reported LAs (40.4% and 39.2%, respectively). Serious AEs constituted 46.2%, more commonly in females than males (56.6% vs 43.4%, <em>P</em> &lt; .001) and in those on concomitant medications (70.2% vs 42.2, <em>P</em> &lt; .001). These were also significantly higher in epinephrine-containing LAs (70.1%) than that without (34.2%, <em>P</em> &lt; .01). Ester LAs had increased risk of serious AEs (odds ratios [OR]: 3.86; 95% confidence intervals [CI]: 2.77-5.39), particularly as hospitalization, life-threatening event, or death. The odds of serious AEs were lower with lidocaine (OR: 0.59; 95% CI: 0.48-0.71) and articaine (OR: 0.63; 95% CI: 0.52-0.76).</div></div><div><h3>Conclusion</h3><div>Our study showed higher rate of serious AEs with ester LAs and those with vasoconstrictor-added practices. Besides, serious outcomes appear as more likely in females and those where additional drug use was reported.</div></div><div><h3>Clinical Relevance</h3><div>The integration of clinical evidence with pharmacovigilance data has the potential to influence clinicians’ LA preferences in dental practice, enabling more informed and evidence-based decision-making.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 3","pages":"Pages 1705-1712"},"PeriodicalIF":3.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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