International dental journal最新文献

{"title":"Can Large Language Models Serve as Reliable Tools for Information in Dentistry? A Systematic Review","authors":"Nora Alhazmi ,&nbsp;Aram Alshehri ,&nbsp;Fahad BaHammam ,&nbsp;Manju Philip ,&nbsp;Muhammad Nadeem ,&nbsp;Sanjeev Khanagar","doi":"10.1016/j.identj.2025.04.015","DOIUrl":"10.1016/j.identj.2025.04.015","url":null,"abstract":"<div><div>Large language models (LLMs) have gained popularity among dental students for generating subject-related answers. However, their widespread use raises significant concerns about misinformation. This systematic review aims to critically evaluate studies assessing the performance of LLMs in dentistry. A comprehensive electronic search was conducted in PubMed/Medline, Scopus, Embase, Web of Science, Google Scholar, and the Saudi Digital Library to identify studies published up to September 2024. The study quality was assessed using the Prediction Model Risk of Bias Assessment Tool (PROBAST). A total of 2030 studies have been identified. After removing 907 duplicate records, 1123 studies remained for screening. Ultimately, 31 studies met the inclusion criteria. Approximately half of these studies were classified as “high risk,” while the remainder were classified as “low risk.” The applicability of the findings was rated as “low concern.” The primary limitations of LLMs include their inability to specify information sources and their tendency to generate fabricated citations. Based on this review, LLMs hold promise as supplementary educational tools in dentistry. Evidence indicates that students using LLMs may achieve improved academic performance compared to traditional methods. However, concerns about occasional inaccuracies and unreliable citations underscore the need for further research, integration with validated sources, and adherence to ethical guidelines. Ultimately, LLMs should be viewed as complementary tools within dental education, with careful consideration of their limitations.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 4","pages":"Article 100835"},"PeriodicalIF":3.2,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Novel Boron-doped Mesoporous Bioactive Glass Nanoparticles Loaded Alginate Hydrogel in Dogs","authors":"Marwa Samir Naga ,&nbsp;Elbadawy Abdel Aziz Kamoun ,&nbsp;Maha Abdel Moaty ,&nbsp;Ahmed Zaki Ghareeb ,&nbsp;Mona Mohy El Din ,&nbsp;Samia Soliman Abdel Rehim Omar","doi":"10.1016/j.identj.2025.04.008","DOIUrl":"10.1016/j.identj.2025.04.008","url":null,"abstract":"<div><h3>Introduction</h3><div>Dentin regeneration is pivotal to preserve tooth vitality. This study aims to evaluate, histologically, the dentine regenerative potential of a novel injectable boron-doped, mesoporous, bioactive glass nanoparticle (BMBGNPs) loaded alginate hydrogel in dogs</div></div><div><h3>Methods</h3><div>The formulation and optimisation of the novel alginate/BMBG NPs (20 wt. %) loaded composite hydrogel were performed. Next, 66 teeth of 3 dogs were allocated into 3 groups (each including 22 teeth) according to post-operative follow-up period: group I: 2 weeks, group II: 4 weeks, and group III: 8 weeks. Each group was further subdivided according to pulpotomy filling material into two subgroups, with subgroup 1 (alginate/BMBGNPs (20 wt. %) loaded hydrogel) and subgroup 2 mineral trioxide aggregate (MTA). Pulp chambers were mechanically exposed through class V cavities. A complete pulpotomy was executed. The tested materials were positioned on the radicular pulp and finally covered with resin composite restorations. One dog was sacrificed after 2, 4, and 8 weeks. Teeth were prepared for histological evaluation assessing inflammatory cell response, pulp tissue organisation, and dentin bridge formation. The Mann-Whitney <em>U</em> test was employed to evaluate the scores of histological parameters between tested materials (<em>P</em> ≤ .05).</div></div><div><h3>Results</h3><div>Alginate/BMBG NPs (20 wt. %) loaded hydrogel showed normal pulp configuration at 2 and 4 weeks, which was enhanced after 8 weeks (<em>P</em> ≤ .05). Moderate inflammatory reaction was noted at 2 weeks, which was improved after 4 and 8 weeks (<em>P</em> ≤ .05). MTA group demonstrated less favourable pulpal response and inflammatory reaction with a statistically significant difference across all observational periods (<em>P</em> ≤ .05). After 8 weeks all teeth in group 1 exhibited the thickest dentin bridge (<em>P</em> ≤ .05).</div></div><div><h3>Conclusions</h3><div>Alginate/BMBG NPs (20 wt. %) loaded hydrogel offers the promise of regenerating dentin and maintaining pulp vitality reaching the desired level as an alternative to MTA.</div></div><div><h3>Clinical Relevance</h3><div>Alginate/BMBG NP loaded hydrogel is an alternative, reliable option for vital pulp therapy.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 4","pages":"Article 100828"},"PeriodicalIF":3.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging Roles of Periodontal Pathogen–Derived Outer Membrane Vesicles in NAFLD","authors":"Congcong Lv ,&nbsp;Kaikai Shi ,&nbsp;Yadong Guo,&nbsp;Zixin Guo,&nbsp;Pingchan Luo,&nbsp;Lijing Wang,&nbsp;Zhe Wu,&nbsp;Pei Yu","doi":"10.1016/j.identj.2025.03.029","DOIUrl":"10.1016/j.identj.2025.03.029","url":null,"abstract":"<div><div>The rising incidence of nonalcoholic fatty liver disease (NAFLD) poses a great socioeconomic burden worldwide. Also, periodontitis is the most common chronic inflammatory disease caused by a group of oral pathogens, affecting both oral health and systemic conditions, especially liver disease. Although accumulating evidence has elucidated an association between periodontal pathogens and NAFLD, the role of periodontal pathogen–derived outer membrane vesicles (OMVs) has not yet been clarified. In this comprehensive review, we aim to address this gap by summarising the progression and pathogenesis of NAFLD and revealing the relationship between periodontal disease and NAFLD multidimensionally. Additionally, this review sheds light on the multifunctional roles of periodontal pathogens OMVs and emphasises that periodontal pathogen–derived OMVs promote the development of NAFLD by stimulating Kupffer cells to produce inflammatory factors and inducing the activation of Hepatic stellate cells. However, it is still controversial whether periodontal pathogen–derived OMVs can be transferred to the liver through the bloodstream route or the oral-gut-liver axis. This highlights the pressing need for continued research efforts to develop new and optimised research schemes to observe the formation of the systemic distribution pathway of periodontal pathogen–derived OMVs. Finally, it is notable that there are currently no relevant clinical treatment guidelines to make specific provisions on controlling the level of periodontal pathogen–derived OMVs in patients with NAFLD. Guidelines developed based on our findings may contribute to the standardisation of practices. It can also provide effective strategies and potential therapeutic targets for NAFLD patients with periodontitis to alleviate the development of NAFLD diseases by inhibiting periodontal pathogens OMVs.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 4","pages":"Article 100825"},"PeriodicalIF":3.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facts and Fallacies of the Fluoride Controversy: A Contemporary Perspective","authors":"Lakshman Samaranayake ,&nbsp;Thantrira Porntaveetus ,&nbsp;James Tsoi ,&nbsp;Nozimjon Tuygunov","doi":"10.1016/j.identj.2025.04.013","DOIUrl":"10.1016/j.identj.2025.04.013","url":null,"abstract":"<div><div>Fluoride is a natural element recognized for its dental benefits. Fluoride prevents caries due to its antimicrobial activity, enhancing enamel resistance and promoting remineralization After decades of fluoridation of municipal water supplies to reduce dental caries, an intense debate has resurfaced regarding water fluoridation as a public health strategy to combat caries. This renewed discourse occurs against the backdrop of extensive data that clearly demonstrate the vital role of fluoride in caries prevention. Indeed, the Centres for Disease Control and Prevention has stated water fluoridation as 1 of the top ten public health interventions in the twentieth century. The FDI World Dental Federation also advocates systemic fluoride use as a cost-effective caries prevention strategy, and supports its inclusion in public health policies through a number of policy directives. This debate in the US has intensified as a Court concluded that water fluoridation poses unreasonable risks such as reduction of the intelligence quotient (IQ) in children. Additionally, recent statements from the leadership of the US Health and Human Services agency suggest that water fluoridation may cause more harm than good leading some states, like Utah, to revoke fluoridation mandates This article aims to provide a contemporary perspective on fluoride by revisiting its benefits, controversies, and potential risks. It highlights the dual role of fluoride in both individual oral care and public health and underscores the necessity for safe, equitable, and effective delivery strategies tailored to the needs of diverse populations, balancing its preventive advantages with potential health concerns. The review culminates with a summary of policy statements from the FDI World Dental Federation regarding the promotion of oral health through both systemic and topical fluoridation.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 4","pages":"Article 100833"},"PeriodicalIF":3.2,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biodentine Counteracts the Aging Process of Human Dental Pulp Stem Cells Through Wnt/β-Catenin Pathway","authors":"Qi Zhang ,&nbsp;Shujie Cao ,&nbsp;Min Zhang ,&nbsp;Daming Wu ,&nbsp;Chengfei Zhang ,&nbsp;Jin Li","doi":"10.1016/j.identj.2025.03.028","DOIUrl":"10.1016/j.identj.2025.03.028","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to evaluate the effects of Biodentine on human Dental Pulp Stem Cells (hDPSCs) proliferation and senescence and explore the underlying anti-aging mechanism.</div></div><div><h3>Methods</h3><div>hDPSCs were isolated from two groups of patients aged 18 to 27 and 60 to 70 years and treated with Biodentine extract. The optimal concentration of Biodentine extract was determined using the CCK-8 assay. Biodentine treatment on hDPSCs proliferation and aging was assessed using qRT-PCR and Western blot. The small molecule inhibitor XAV939, targeting the Wnt/β-catenin signaling pathway, was added to investigate the anti-aging mechanism of Biodentine in hDPSCs.</div></div><div><h3>Results</h3><div>The isolated hDPSCs exhibited mesenchymal stem cells (MSCs) characteristics, and the proportion of S-phased cells decreased significantly in the aged group. Biodentine promoted hDPSCs proliferation, with the most pronounced effect observed at 0.2 mg/mL. qRT-PCR showed that Biodentine enhanced the expression of odonto/osteogenesis-related genes. Senescence-associated β-galactosidase staining and Western blot analysis further demonstrated the significant anti-aging effect of Biodentine on hDPSCs. Western blot revealed that Biodentine exerted its anti-aging effect through the Wnt/β-catenin signaling pathway.</div></div><div><h3>Conclusion</h3><div>The study demonstrated that Biodentine promotes proliferation and exerts anti-aging effects on hDPSCs through the Wnt/β-catenin pathway.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 4","pages":"Article 100819"},"PeriodicalIF":3.2,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-Driven Dental Caries Management Strategies: From Clinical Practice to Professional Education and Public Self Care","authors":"Yutong Liang ,&nbsp;Dongling Li ,&nbsp;Dongmei Deng ,&nbsp;Chun Hung Chu ,&nbsp;May Lei Mei ,&nbsp;Yunpeng Li ,&nbsp;Na Yu ,&nbsp;Jinzhi He ,&nbsp;Lei Cheng","doi":"10.1016/j.identj.2025.04.007","DOIUrl":"10.1016/j.identj.2025.04.007","url":null,"abstract":"<div><div>Dental caries is one of the most prevalent chronic diseases among both children and adults, despite being largely preventable. This condition has significant negative impacts on human health and imposes a substantial economic burden. In recent years, scientists and dentists have increasingly started to utilize artificial intelligence (AI), particularly machine learning, to improve the efficiency of dental caries management. This study aims to provide an overview of the current knowledge about the AI-enabled approaches for dental caries management within the framework of personalized patient care. Generally, AI works as a promising tool that can be used by both dental professionals and patients. For dental professionals, it predicts the risk of dental caries by analyzing dental caries risk and protective factors, enabling to formulate personalized preventive measures. AI, especially those based on machine learning and deep learning, can also analyze images to detect signs of dental caries, assist in developing treatment plans, and help to make a risk assessment for pulp exposure during treatment. AI-powered tools can also be used to train dental students through simulations and virtual case studies, allowing them to practice and refine their clinical skills in a risk-free environment. Additionally, AI tracks brushing patterns and provides feedback to improve oral hygiene practices of the patients and the general population, thereby improving their understanding and compliance. This capability of AI can inform future research and the development of new strategies for dental caries management and control.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 4","pages":"Article 100827"},"PeriodicalIF":3.2,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143931503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mucoperiosteal Flap Healing During Vertical Bone Augmentation using Titanium Mesh: A Study in Beagle Dogs","authors":"Lan Wang,&nbsp;Yang Zhou,&nbsp;Renshengjie Zhao,&nbsp;Keming Xiao,&nbsp;Maoyun Zeng,&nbsp;Xinyu Xie,&nbsp;Qiqi Liu,&nbsp;Ke Yu","doi":"10.1016/j.identj.2025.04.004","DOIUrl":"10.1016/j.identj.2025.04.004","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>The periosteal releasing incision (PRI) is often used in guided bone regeneration (GBR) with titanium (Ti) mesh to reduce the tension of mucoperiosteal flaps (MPF) and close the wound, but it can easily lead to keratinized gingiva (KG) narrowing and a high wound dehiscence rate. Therefore, it is necessary to explore alternative methods such as open healing. The aim of this study was to observe whether a MPF without a PRI and primary closure could heal on a titanium membrane surface in vertical bone augmentation and to measure the change in KG width.</div></div><div><h3>Methods</h3><div>The bilateral mandibular second, third, and fourth premolars and first molars were extracted from 6 beagle dogs. After 3 months, 4 sites were prepared on each side of the mandible to perform vertical bone augmentation and divided into 4 groups using a randomized block design. Group A: Bio-oss + Ti-membrane + Bio-gide + PRI and closing MPF; Group B: Bio-oss + Ti-membrane + Bio-oss + Bio-gide + PRI and closing MPF; Group C: Bio-oss + Ti-membrane + Bio-oss + Bio-gide + no PRI and unclosing MPF; and Group D: Ti-membrane + Bio-gide + no PRI and closing MPF. The study parameters were wound healing rate and dehiscence rate, KG widths, histologic analysis of gingiva, and analysis of the Ti-membranes surface.</div></div><div><h3>Results</h3><div>The wound dehiscence rates in groups A, B, and D were 50%, 41.67%, and 8.3%, respectively, and there was no statistical difference between group A and group B (<em>P</em> = 1.000). And in group C, only 1 wound exhibited incomplete soft-tissue closure of the gum (8.3%). The KG width in group C increased by 1.77 ± 0.37 mm, while the KG width in group B decreased by 4.37 ± 0.45 mm, and there was a significantly statistical difference between the 2 groups (<em>P</em> &lt; .001). Compared to group B, the new gingiva in group C had better histological performance.</div></div><div><h3>Conclusion</h3><div>An MPF without PRI and primary closure can heal on the clean surface of the Ti membrane during vertical bone augmentation, and the KG can widen.</div></div><div><h3>Clinical Relevance</h3><div>The results have implications for the postoperative wound management of GBR supported by a titanium membrane.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 4","pages":"Article 100823"},"PeriodicalIF":3.2,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Management Improves Patient Outcomes in Hematopoietic Stem Cell Transplantation","authors":"Mutsuko Moriwaki ,&nbsp;Mikayo Toba ,&nbsp;Makiko Takizawa ,&nbsp;Hiroaki Shimizu ,&nbsp;Haruna Tanaka ,&nbsp;Chihiro Takahashi ,&nbsp;Shinobu Imai ,&nbsp;Masayuki Kakehashi ,&nbsp;Kiyohide Fushimi","doi":"10.1016/j.identj.2025.04.003","DOIUrl":"10.1016/j.identj.2025.04.003","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>Oral bacteria influence bloodstream infections in hematopoietic stem cell transplantation (HSCT). We investigated the effects of oral health management and its relationship with medical care delivery systems.</div></div><div><h3>Methods</h3><div>Patients aged &gt;16 years who underwent HSCT, discharged from Japanese acute care hospitals between April 2018 and March 2022, were categorized into autologous and allogeneic HSCT groups. Multivariable analysis assessed the impact of peri-HSCT oral management on antibiotic use, narcotic injections, and mortality rates.</div></div><div><h3>Results</h3><div>We included 12,248 patients, 5936 autologous and 6312 allogeneic HSCT patients, across 298 hospitals. The defined daily dose (DDD) of antibiotic use within 14 days post-transplantation in the oral and nonoral management groups for allogeneic HSCT patients was 34.10 (standard deviation [SD] 20.35) vs 36.37 (SD 21.33); broad-spectrum antibiotics use was 23.87 (SD 15.82) vs 24.45 (SD 15.76). Within 30 days post-transplantation, the DDD of antibiotic use was 69.13 (SD 40.18) vs 75.16 (SD 43.47) was 45.70 (SD 29.63) vs 47.95 (SD 30.48), respectively. In allogeneic HSCT patients, oral management resulted in lower DDD of antibiotic use by 2.66 within 14 days and 6.74 within 30 days post-transplantation, after adjustment for relevant factors. Broad-spectrum antibiotic use within 30 days post-transplantation showed a lower DDD by 2.79 (<em>P</em> &lt; .01). Narcotic use led to a 0.34 lower DDD (<em>P</em> &lt; .01) within 14 days and 0.70 lower DDD (<em>P</em> &lt; .01) within 30 days. In autologous HSCT patients, oral management did not affect the outcomes. The certification standard for unrelated HSCT, categorized into four classes (no certification and certification levels 1-3), was associated with an 8.41 point increase in hospital oral management implementation per class.</div></div><div><h3>Conclusion</h3><div>Ensuring an appropriate oral environment for allogeneic HSCT patients helps preventing infection, extending life expectancy, and alleviating pain.</div></div><div><h3>Clinical relevance</h3><div>Coordinated care between dental and medical teams is essential to deliver safe, personalized, and high-quality patient outcomes during HSCT.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 4","pages":"Article 100822"},"PeriodicalIF":3.2,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of different surface treatments on the bond strength of different monolithic zirconia with dentin","authors":"Ahmad Abdulkareem Alnazzawi ,&nbsp;Mohammed H. AbdElaziz ,&nbsp;Ahmed E. Farghal ,&nbsp;Mohamed F. Aldamaty ,&nbsp;Sary Borzangy ,&nbsp;Sultan Ainoosah ,&nbsp;Ahmed Yaseen Alqutaibi","doi":"10.1016/j.identj.2025.03.021","DOIUrl":"10.1016/j.identj.2025.03.021","url":null,"abstract":"<div><h3>Aim</h3><div>This study investigates the effects of different surface treatments on the microstructure, topography, and shear bond strength (SBS) of monolithic zirconia with varying yttria content (3Y and 5Y).</div></div><div><h3>Materials and methods</h3><div>A total of 160 zirconia specimens underwent surface treatments, including air-particle abrasion (APA), hydrofluoric acid etching (HF), and hot hydrofluoric acid etching (HHF), with half receiving primer application prior to resin cement bonding. Scanning electron microscopy and X-ray diffraction analyses evaluated surface morphology and crystalline phase composition, while SBS was tested using a universal testing machine.</div></div><div><h3>Results</h3><div>Scanning electron microscopy revealed distinct roughness patterns for each treatment, with APA producing microretentive grooves, HF creating shallow fissures, and HHF forming uniform, deeper grooves, particularly in 5Y zirconia. X-ray diffraction confirmed crystalline alterations due to treatments. SBS values were highest for APA (18.11 ± 10.02 MPa) and HHF (18.02 ± 9.95 MPa) treatments (<em>P</em> ˂ .0001), with primer application significantly enhancing SBS across all groups (<em>P</em> ˂ .0001). 5Y zirconia exhibited superior SBS (15.65 ± 9.05 MPa) compared to 3Y zirconia (13.76 ± 8.66 MPa) (<em>P</em> ˂ .0001). Failure modes transitioned from adhesive in controls to mixed in treated groups.</div></div><div><h3>Conclusion</h3><div>APA and HHF, combined with primer application, were effective methods to enhance the shear bond strength of 3Y and 5Y zirconia. Further research is needed to study their long-term stability under clinical conditions.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 4","pages":"Article 100812"},"PeriodicalIF":3.2,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143918581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Nanoparticle, Fluorescence-Based Rinse for Caries Activity Assessment, an in Vitro Study","authors":"Bruna Leticia Vessoni Menoncin ,&nbsp;Wendy Bloembergen ,&nbsp;Nathan Jones ,&nbsp;Adam Hoxie ,&nbsp;Matthew Finkelman ,&nbsp;Andrea Ferreira Zandona","doi":"10.1016/j.identj.2025.02.003","DOIUrl":"10.1016/j.identj.2025.02.003","url":null,"abstract":"<div><h3>Objectives</h3><div>This in vitro study aimed to compare the agreement of a starch-based nanoparticle fluorescence rinse (FR) (LumiCare™ Caries Detection Rinse, GreenMark Biomedical Inc.) in the assessment of caries activity of initial smooth surface carious lesions with the International Caries Classification and Management System (ICCMS) Lesion Activity Assessment.</div></div><div><h3>Methods</h3><div>A convenience sample of permanent extracted human teeth (N = 57) were scored by visual assessment (VA) using the ICCMS activity criteria by 2 calibrated examiners. VA categories included: sound, inactive and active. For fluorescence assessment (FA), each tooth was fully immersed in FR for 30 seconds, rinsed with water for 10 seconds, compressed air dried and examined under an orange filter while illuminating with a curing light. Fluorescence was assessed as no fluorescence or fluorescence. Both VA and FA were repeated after at least 24 hours and Kappa was calculated for inter- and intra-examiner agreement.</div></div><div><h3>Results</h3><div>Based on VA, 12 teeth (21%) were classified into the active category, while 45 teeth (79%) were classified into the sound (n = 20) or inactive (n = 25) categories. When combining the latter 2 categories, VA and FA’s classifications were concordant in 100% of cases (all 12 teeth in VA’s active category exhibited fluorescence, and all 45 teeth in VA’s sound/inactive category did not exhibit fluorescence according to FA; Kappa = 1).</div></div><div><h3>Conclusion</h3><div>FA with FR demonstrated perfect agreement with VA using ICCMS when comparing active versus inactive and/or sound surfaces suggesting it has potential as an objective indicator of caries activity.</div></div><div><h3>Clinical significance</h3><div>A fluorescence rinse could improve clinical detection of smooth surface caries activity and <strong>c</strong>ould easily be integrated as part of the dental hygiene appointment.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 4","pages":"Article 100764"},"PeriodicalIF":3.2,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143911485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}