International dental journal最新文献

{"title":"Responses to Comments on \"Image-Based Diagnostic Performance of LLMs vs CNNs for Oral Lichen Planus\".","authors":"Paak Rewthamrongsris, Jirayu Burapacheep, Ekarat Phattarataratip, Promphakkon Kulthanaamondhita, Antonin Tichy, Falk Schwendicke, Thanaphum Osathanon, Kraisorn Sappayatosok","doi":"10.1016/j.identj.2025.100889","DOIUrl":"https://doi.org/10.1016/j.identj.2025.100889","url":null,"abstract":"","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":"100889"},"PeriodicalIF":3.2,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ARA290 Attenuates Apical Periodontitis via SIRT1/NF-κB/IL-1β Pathway Modulation","authors":"Yuting Wang ,&nbsp;Yifei Tang ,&nbsp;Mingfei Wang ,&nbsp;Wenlan Li ,&nbsp;Wenli Mu ,&nbsp;Abdelrahman Seyam ,&nbsp;Yating Dai ,&nbsp;Tiezhou Hou ,&nbsp;Xiaoyue Guan","doi":"10.1016/j.identj.2025.100863","DOIUrl":"10.1016/j.identj.2025.100863","url":null,"abstract":"<div><h3>Introduction and Aims</h3><div>Existing research suggests that ARA290 may possess therapeutic potential for apical periodontitis (AP), although the mechanisms involved remain unclear. This study aims to investigate the protective effects and underlying mechanisms of ARA290 in mitigating pro-inflammatory responses of macrophages in the context of AP.</div></div><div><h3>Methods</h3><div>Initially, <em>in vivo</em> models of AP were used to assess the aberrant activation of the SIRT1/NF-κB/IL-1β signalling pathway within periapical lesions. Furthermore, the expression levels of the SIRT1/NF-κB/IL-1β signalling pathway in ARA290-treated AP models, both <em>in vivo</em> and <em>in vitro</em>, were evaluated using immunohistochemistry (IHC), Western blotting, and immunofluorescence (IF) techniques to elucidate the role of ARA290 in modulating this signalling pathway during AP pathogenesis. Subsequently, the SIRT1/NF-κB/IL-1β signalling pathway was inhibited using selisistat, and the resultant changes in inflammatory levels and bone resorption in periapical lesions were assessed through haematoxylin and eosin staining, tartrate-resistant acid phosphatase staining, IHC and micro-computed tomography (Micro CT).</div></div><div><h3>Results</h3><div>The <em>in vivo</em> AP model demonstrated a 50% reduction in SIRT1 expression within periapical lesions, accompanied by a 5-fold increase in the expression of acetylated NF-κB (p65) and IL-1β. Additionally, the administration of ARA290 in the AP mouse model significantly reduced inflammatory infiltration, the number of osteoclasts and the extent of bone loss in the periapical region. Notably, ARA290 treatment enhanced SIRT1 expression by approximately 40% while concurrently decreasing the levels of acetylated NF-κB (p65) by around 75% and IL-1β by approximately 62.5% in both <em>in vivo</em> and <em>in vitro</em> AP models. Importantly, inhibition of the SIRT1/NF-κB/IL-1β signalling pathway negated the beneficial effects of ARA290 in attenuating the progression of AP.</div></div><div><h3>Conclusions</h3><div>ARA290 plays a protective role by modulating the SIRT1/NF-κB/IL-1β signalling pathway in apical periodontitis, which may provide a new direction for the adjuvant treatment of apical periodontitis.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 5","pages":"Article 100863"},"PeriodicalIF":3.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Parental Health Beliefs on Early Childhood Caries: A Two-Year Longitudinal Study","authors":"Yi-Chang Chou ,&nbsp;Feng-Shiang Cheng ,&nbsp;Shih-Han Weng ,&nbsp;Chih-Hao Tseng ,&nbsp;Hsiao-Yun Hu ,&nbsp;Chieh-Hsing Liu","doi":"10.1016/j.identj.2025.100902","DOIUrl":"10.1016/j.identj.2025.100902","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>Early childhood caries (ECC) is a widespread chronic condition that significantly affect children’s health and well-being. Although parental psychosocial factors are key to shaping children’s oral health behaviours, few studies have examined the distinct influences of fathers’ vs mothers’ health beliefs. The Health Belief Model (HBM) – which examines health behaviours through perceived susceptibility, severity, benefits, barriers, and self-efficacy – provides a valuable framework for examining these dynamics. This study applied the HBM to investigate the associations between caregiver beliefs, behaviours, and ECC risk, with a focus on differences between fathers and mothers.</div></div><div><h3>Methods</h3><div>We conducted a longitudinal analysis utilizing data from the Taipei Preschool Oral Health Screening Program (2017-2018), including children aged 3-5 years. Eligible participants had complete oral examination records and parental HBM-based questionnaires for 2 consecutive years. Children with incomplete questionnaires were excluded, yielding a final sample of 6902. Generalized estimating equations assessed associations between caregiver oral health beliefs, self-efficacy, perceived barriers, cues to action, behaviours, and ECC risk, stratified by caregiver type (father or mother).</div></div><div><h3>Results</h3><div>Higher parental education, better child oral health behaviours, lower perceived barriers, and greater self-efficacy were significantly correlated with reduced ECC risk. Conversely, higher cues to action were linked to increased ECC risk, indicating a reactive rather than preventive approach. Stratified analyses revealed differing patterns: among fathers, only education and oral health knowledge were significantly protective, whereas among mothers, child oral health behaviours, perceived barriers, and self-efficacy were also significant predictors.</div></div><div><h3>Conclusion</h3><div>Parental psychosocial factors substantially influence ECC risk, with distinct roles for fathers and mothers. These findings highlight the importance of considering caregiver gender in future research and oral health intervention design.</div></div><div><h3>Clinical relevance</h3><div>Family-centred, gender-specific interventions that address caregiver-specific beliefs and behaviours may improve ECC prevention strategies and help reduce oral health disparities in preschool-aged children.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 5","pages":"Article 100902"},"PeriodicalIF":3.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clarifying the Findings of Our Study on Large Language Models and Infective Endocarditis Prophylaxis","authors":"Paak Rewthamrongsris,&nbsp;Jirayu Burapacheep,&nbsp;Vorapat Trachoo,&nbsp;Thantrira Porntaveetus","doi":"10.1016/j.identj.2025.100887","DOIUrl":"10.1016/j.identj.2025.100887","url":null,"abstract":"","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 5","pages":"Article 100887"},"PeriodicalIF":3.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classic Publications in the Field of Dentistry: A Bibliometric Analysis","authors":"Yuh-Shan Ho ,&nbsp;Nikolaos Christidis","doi":"10.1016/j.identj.2025.100909","DOIUrl":"10.1016/j.identj.2025.100909","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>This bibliometric study aimed to identify and analyze the classic articles in the Web of Science category ‘Dentistry, Oral Surgery and Medicine,’ providing insights into the characteristics, citation patterns, and evolving trends that define the field's most influential publications.</div></div><div><h3>Methods</h3><div>Articles published between 1960 and 2020 were extracted from the Science Citation Index Expanded (SCI-EXPANDED) database. Classic articles were defined as those with ≥1000 citations as of the end of 2024. Bibliometric indicators such as total citations (<em>TC₂₀₂₄</em>), citations in 2024 (<em>C₂₀₂₄</em>), citations per publication (<em>CPP₂₀₂₄</em>), and authorship patterns were analyzed. Citation trajectories, author keywords, and institutional and international collaborations were also assessed.</div></div><div><h3>Results</h3><div>A total of 42 classic articles were identified. These publications were most frequently produced in the 1990s and 2000s and originated predominantly from the USA and Sweden. The University of North Carolina and the University of Gothenburg were particularly prominent. Periodontology, implantology, dental materials, and oral epidemiology were common themes. Articles such as Socransky et al. and Schiffman et al. demonstrated both sustained and recent citation influence. Word frequency analysis highlighted topics such as plaque, periodontal disease, and classification systems. Citation histories revealed diverse trajectories, including delayed recognition and rapid recent influence.</div></div><div><h3>Conclusion</h3><div>Classic articles in dental research reflect the field’s shift toward evidence-based practice, interdisciplinary collaboration, and public health relevance. By mapping these highly cited works, this study provides a clearer understanding of the factors contributing to long-term scientific impact in dentistry, oral surgery, and medicine.</div></div><div><h3>Clinical relevance</h3><div>This study identifies highly cited publications that have shaped clinical practice in periodontology, implantology, temporomandibular disorders, wound healing, and oral-systemic health. These works continue to guide diagnostics, treatment planning, and public health strategies, highlighting the lasting impact of foundational research and the importance of interdisciplinary, evidence-based approaches in dentistry.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 5","pages":"Article 100909"},"PeriodicalIF":3.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASXL2 Modulates Chromatin Remodeling to Direct Osteogenesis and Multiple Cell Fate in hPDLSCs","authors":"Tianle Yang ,&nbsp;Ying Zhou ,&nbsp;Ruohui Han ,&nbsp;Meilin Hu ,&nbsp;Bo Zeng ,&nbsp;Hong Shi ,&nbsp;Dayong Liu","doi":"10.1016/j.identj.2025.100900","DOIUrl":"10.1016/j.identj.2025.100900","url":null,"abstract":"<div><h3>Aims</h3><div>This study investigates the epigenetic role of Additional Sex Combs-Like 2 (ASXL2) in regulating osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs), aiming to address limitations in current strategies for oral and maxillofacial tissue regeneration.</div></div><div><h3>Methods</h3><div>Lentiviral-mediated <em>ASXL2</em> knockdown in hPDLSCs was validated by flow cytometry. Functional impacts were assessed through proliferation/apoptosis assays, alkaline phosphatase (ALP) activity, Alizarin Red mineralization, and qPCR/Western blot analyses of osteogenic markers (RUNX2, ALP, COL1A1, OCN). Global histone modification dynamics (H2AK119ub, H3K27me3, H3K4me3) were detected to elucidate epigenetic mechanisms.</div></div><div><h3>Results</h3><div><em>ASXL2</em> depletion enhanced hPDLSC proliferation and reduced apoptosis, but critically impaired osteogenic differentiation, evidenced by suppressed ALP activity and mineralization. Global downregulation of osteogenic markers is correlated with altered chromatin states: decreased activating H3K4me3 and increased repressive H2AK119ub/H3K27me3.</div></div><div><h3>Conclusion</h3><div>ASXL2 modulates the osteogenic competency of hPDLSCs through epigenetic regulation, wherein its loss disrupts transcriptional accessibility by skewing histone modification balance: suppressing H3K4me3-mediated activation while amplifying H2AK119ub/H3K27me3-dependent repression to downregulate specific osteogenic genes.</div></div><div><h3>Clinical Relevance</h3><div>ASXL2 emerges as a pivotal epigenetic target for craniofacial regeneration. Strategic modulation of ASXL2 activity may optimize hPDLSC-based therapies to restore masticatory, pronunciation, and aesthetic functions.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 5","pages":"Article 100900"},"PeriodicalIF":3.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Candida in Orthodontic Patients Wearing Removable Orthodontic Appliances: A Systematic Review and Meta-Analysis","authors":"Kreaukarn Siripaisanprasert ,&nbsp;Chanwit Prapinjumrune ,&nbsp;Chidsanu Changsiripun","doi":"10.1016/j.identj.2025.100905","DOIUrl":"10.1016/j.identj.2025.100905","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the impact of removable orthodontic appliances (ROA) on oral <em>Candida</em> colonization using a systematic review approach.</div></div><div><h3>Methods</h3><div>We searched for human studies published from inception to April 29, 2024, in PubMed, Scopus, Cochrane central, and the VHL regional portal. Studies on oral <em>Candida</em> colonization in ROA wearers with acrylic components covering the oral mucosa, involving participants aged between 6 and 40 years, were considered eligible. Data on oral <em>Candida</em> colonization categorized by treatment period—before, during, and after ROA use— were the outcomes of interest. Additionally, the data for the treatment period were further subdivided into 4 timeframes: immediate-term (&lt;3 months), short-term (≥3-6 months), mid-term (≥6-12 months), and long-term (≥12 months). The quality of the included studies was assessed using appropriate tools based on their study designs, and a random-effects meta-analysis was conducted to pool the data, reporting odds ratios with 95% confidence intervals.</div></div><div><h3>Results</h3><div>Of the 1,269 records identified, 7 observational studies met the inclusion criteria. These included 3 cross-sectional studies and 4 before-after studies. Based on the follow-up period, no significantly higher prevalence of oral <em>Candida</em> colonization was observed in the immediate-term treatment group compared with the before-treatment group (<em>P = .</em>15). However, oral <em>Candida</em> colonization was significantly more prevalent in the short-term and mid-term ROA wearers compared with the before-treatment group (<em>P = .</em>0006 and <em>P = .</em>001, respectively).</div></div><div><h3>Conclusions</h3><div>Wearing removable orthodontic appliances for longer than 3 months increases the prevalence of oral <em>Candida</em> colonization. However, further randomized controlled trials are needed.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 5","pages":"Article 100905"},"PeriodicalIF":3.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Oral Health Education for Nurses and Community Health Workers (Project OHE-NCHeW) in Nigeria","authors":"Abimbola M. Oladayo ,&nbsp;Folake B. Lawal ,&nbsp;Oyinkansola O. Sofola ,&nbsp;Omolara G. Uti ,&nbsp;Afolabi Oyapero ,&nbsp;Adetayo Aborisade ,&nbsp;Mojisola Olujitan ,&nbsp;Omotayo F. Fagbule ,&nbsp;Adeola T. Williams ,&nbsp;Aderonke Dedeke ,&nbsp;Ejiro Idiga ,&nbsp;Yahya-Imam Abdul-Kabir Adegoke ,&nbsp;Ilori Adeniji Oluwagbenga ,&nbsp;Aishatu Baba Mele ,&nbsp;Amina Sani Baffa ,&nbsp;Ifeoluwa Adetula ,&nbsp;Khadija Saad Musa ,&nbsp;Bernal Stewart ,&nbsp;Carlo Amorin Daep ,&nbsp;Deon Hines ,&nbsp;Azeez Butali","doi":"10.1016/j.identj.2025.100891","DOIUrl":"10.1016/j.identj.2025.100891","url":null,"abstract":"<div><h3>Introduction</h3><div>Educating primary healthcare workers (PHCWs) on oral health and its association with systemic health, as well as equipping them with skills to identify common oral diseases for referral to the dentist, is crucial for improving overall health outcomes in underserved regions. However, traditional oral health education programs for PHCWs have yet to increase patient referrals to dental centers significantly, hence the need for competency-based oral health training. This study evaluated the effectiveness of a competency-based oral health training pilot program <strong>–</strong> <em>Project OHE-NCHeW</em> on the oral health knowledge and referral practices of nurses and community health workers (CHWs) in Nigeria.</div></div><div><h3>Methods</h3><div>We utilized a quasi-experimental design with pre-and post-test assessments. One hundred twenty nurses and CHWs (60 intervention, 60 control) across Lagos, Kano, and Ibadan were recruited via cluster sampling. The intervention group underwent a 5-day competency-based oral health training, while the control group received a single-session lecture. Evaluations were conducted immediately after training and 3 months later to assess knowledge, attitudes, and referral practices (KAP) using a validated questionnaire.</div></div><div><h3>Results</h3><div>Overall, the mean age of the participants was 41.4 ± 10.3 years, with an average of 15.3 ± 9.8 years of practice. Both groups had similar baseline KAP scores. Post-training, the intervention group showed significant improvements in oral health knowledge (<em>P</em> &lt; .0001) and practice scores (<em>P</em> = .0096) only. Referral outcomes varied by location, with Kano logging the highest number of referrals (60.0%), and many (57.5%) of the referred patients attended the clinic (57.5%). Decayed teeth (44.1%) and gum diseases (30.8%) were the most common reasons for referral across all sites<strong>.</strong></div></div><div><h3>Conclusion</h3><div>The pilot training significantly enhanced the PHCW's oral knowledge and referral practices, demonstrating the potential to strengthen primary care and inform policies aimed at integrating oral health into primary care frameworks for broader public health impact.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 5","pages":"Article 100891"},"PeriodicalIF":3.2,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occlusal Analysis of Algorithm-designed Restoration Using Different Virtual Articulator Parameters: A Preliminary Study","authors":"Shan-lin Guo ,&nbsp;Xiao He ,&nbsp;Zhi Tang ,&nbsp;Bing-ying Xie ,&nbsp;Min-jie Mao ,&nbsp;Xiao-qing Shen ,&nbsp;Yuan-ming Geng ,&nbsp;Wei Li","doi":"10.1016/j.identj.2025.100901","DOIUrl":"10.1016/j.identj.2025.100901","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>To investigate how different virtual articulator parameter settings influence clinical outcomes of posterior CAD/CAM restorations designed with the CEREC system's biogeneric model, specifically regarding occlusal rehabilitation.</div></div><div><h3>Methods</h3><div>Twenty participants (11 females, 9 males; mean age 35.50 ± 5.23 years) each received four crowns designed under one of four protocols: (1) No Virtual Articulator Parameters (NVAP), (2) Mean Virtual Articulator Parameters (MVAP), (3) Partially Personalised Virtual Articulator Parameters (PPVAP), and (4) Fully Personalised Virtual Articulator Parameters (FPVAP). Subjective comfort was assessed via the Visual Analogue Scale and Likert scale. Intraoral scans were analysed using Geomagic Control X 2020 software to assess occlusal contact areas and points at single-tooth and full-arch levels. One-year restoration survival was not recorded.</div></div><div><h3>Results</h3><div>MVAP and FPVAP showed significantly lower Visual Analogue Scale scores than NVAP (<em>P</em> = .0084, <em>P</em> = .0002, respectively). Likert scale ratings did not differ among groups (<em>P</em> = .9921). All crown designs reduced occlusal contact areas compared to the pre-preparation state (<em>P</em> &lt; .05), with FPVAP exhibiting the most favorable outcomes, though not significantly different from other designs. Full-arch analysis revealed no significant changes in contact areas (<em>P</em> = .2645) or contact points (<em>P</em> = .5015). Two NVAP restorations fractured within one year (<em>P</em> = .0348), indicating a trend favoring increased parameter personalization.</div></div><div><h3>Conclusions</h3><div>Mean-value or fully personalised virtual articulator parameters in CAD/CAM crown design yield superior patient comfort and maintain more accurate occlusal relationships compared to non-personalised approaches. Mean-value settings present a practical option for general clinical use, although larger-scale studies with extended follow-up are recommended.</div></div><div><h3>Clinical relevance</h3><div>By integrating mean-value or fully personalised virtual articulator parameters into CAD/CAM restoration workflows, clinicians can significantly enhance patient comfort and occlusal accuracy. These findings highlight the importance of tailoring design parameters in routine practice to improve restoration outcomes and potentially lower the likelihood of failure.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 5","pages":"Article 100901"},"PeriodicalIF":3.2,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144633261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Azithromycin Modified Triple Antibiotic Paste in Resolving Periapical Inflammation","authors":"Tingting Meng ,&nbsp;Zhengyang Wang ,&nbsp;Haocong Li ,&nbsp;Zhaoguang Ouyang ,&nbsp;Chenxi Yang ,&nbsp;Tengye Lian ,&nbsp;Yao Zhang ,&nbsp;Huixu Li ,&nbsp;Pingping Bao ,&nbsp;Dayong Liu","doi":"10.1016/j.identj.2025.100895","DOIUrl":"10.1016/j.identj.2025.100895","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to assess the anti-inflammatory and antibacterial properties of traditional and modified triple antibiotic paste. The 16S rDNA was employed to analyse the root canal microbial community's characteristics pre- and post-treatment.</div></div><div><h3>Methods</h3><div>Rabbits with periapical inflammation (AP) were treated with both pastes. Micro-CT was performed to compare the periapical lesion area, followed by HE staining. Inflammatory factors and microorganism were collected for analysis. T-tests and ANOVA were used to analyse the effects of the 2 pastes on tooth discoloration.</div></div><div><h3>Results</h3><div>Compared with the control group, apical lesions and the expression of inflammatory cytokines was decreased, along with a reduction in bone destruction. Antibacterial experiments showed that the 2 antibiotics had similar effects on the common pathogens of AP. Compared with the TAP, mTAP does not cause discoloration of teeth. 16Sr DNA analysis revealed variations in periapical bacteria composition. The contents of common pathogens of AP in TAP and mTAP groups were lower than those in control group.</div></div><div><h3>Conclusions</h3><div>Azithromycin has the potential to serve as an alternative to minocycline. The 16S rDNA data highlights the intricate nature of the root canal microbiome, promising deeper insights into the correlation between microbes and inflammation.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 5","pages":"Article 100895"},"PeriodicalIF":3.2,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}