International dental journal最新文献

{"title":"Asarum sieboldii, a Potential Ethnomedicinal Herb in Dentistry and Oral Health","authors":"Kenneth Happy ,&nbsp;Joyce Mudondo ,&nbsp;Nam-Hui Yim ,&nbsp;Youngmin Kang","doi":"10.1016/j.identj.2025.03.025","DOIUrl":"10.1016/j.identj.2025.03.025","url":null,"abstract":"<div><div><em>Asarum sieboldii</em>, a species of wild ginger native to East Asia, has long been recognised as an important herb in Asian traditional medicine. It has been applied in the treatment of toothache, cough, asthma, and sinusitis. <em>A. sieboldii</em> has gained global interest because it offers solutions to multiple health concerns. The plant is renowned for its anti-inflammatory, analgesic, antimicrobial, antifungal, and antioxidant properties. Its roots exhibit a wide range of biological and pharmacological effects. The plant contains several chemical constituents, including methyleugenol, 3,4,5-trimethoxytoluene, and safrole, which contribute to its medicinal benefits. Whereas literature search highlights the potential application of <em>A. sieboldii</em> in herbal medicine, to date its application in dentistry remains largely unexplored, with the existing literature vastly fragmented in various sources. This review therefore, provides a comprehensive overview of the potential application of <em>A. sieboldii</em> in dentistry and oral health. The plant shows considerable promise and appears to be effective for managing common oral diseases such as tooth decay, periodontal diseases, toothache, oral cancer, oral ulcers, and gingivitis. Its ability to inhibit nitric oxide release, along with its neuroprotective effects, further enhances its potential for relieving pain and inflammation. With these therapeutic benefits, <em>A. sieboldii</em> presents a promising natural alternative or a complementary option to conventional dental treatments, capable of addressing a wide range of oral health conditions. The findings from this review could serve as a solid foundation for future research, supporting the development of high-quality, safe, and effective <em>A. sieboldii</em>–based products in dentistry and oral health.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 4","pages":"Article 100816"},"PeriodicalIF":3.2,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Bone Regeneration Using Demineralized Dentin Matrix: A Comparative Study in Alveolar Bone Repair","authors":"Nessma Sultan ,&nbsp;Bassant Mowafey ,&nbsp;Fatma Ata ,&nbsp;Mona H. El-Zekrid ,&nbsp;Soher Nagi Jayash","doi":"10.1016/j.identj.2025.03.026","DOIUrl":"10.1016/j.identj.2025.03.026","url":null,"abstract":"<div><h3>Objectives</h3><div>Alveolar bone resorption following tooth extraction presents significant challenges for implant-supported rehabilitations. Demineralised dentin matrix (DDM) has emerged as a promising scaffold for bone tissue regeneration. This study evaluates the bone-regenerating potential of varying degrees of dentin demineralisation.</div></div><div><h3>Materials and methods</h3><div>Thirty-two male white New Zealand rabbits underwent extraction of the left mandibular anterior tooth and were assigned to 4 groups: undemineralised dentin matrix (UDDM), partially demineralised dentin matrix (PDDM), completely demineralised dentin matrix (CDDM), and a control group with no treatment. At 4 and 8 weeks post extraction, cone-beam computed tomography (CBCT) was used to assess alveolar bone height and width. Histological analyses using H&amp;E and Masson trichrome stains evaluated new bone formation, and immunohistochemistry detected osteopontin expression.</div></div><div><h3>Results</h3><div>CBCT imaging revealed progressive increases in alveolar bone height and width across all groups over time. Histological analysis showed new bone formation in all groups, with the PDDM group demonstrating closer integration of newly formed bone trabeculae compared with the others. IHC results showed higher osteopontin expression in the PDDM group, highlighting its superior bone-inductive potential.</div></div><div><h3>Conclusion</h3><div>Among the tested materials, PDDM exhibited the most effective bone induction and tissue regeneration capabilities, outperforming CDDM and UDDM in promoting alveolar bone repair. These findings position PDDM as a valuable scaffold for enhancing bone tissue regeneration in clinical applications.</div></div><div><h3>Clinical relevance</h3><div>The use of PDDM in tooth extraction sockets significantly promotes efficient and reliable bone regeneration, making it a valuable option for clinical applications in implant dentistry.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 4","pages":"Article 100817"},"PeriodicalIF":3.2,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Cockle Shell to Bioceramic Root Canal Sealer: The Manufacturing and its Physical and Biological Properties","authors":"Chanathip Chatphatthanasiri ,&nbsp;Thanakorn Wasanapiarnpong ,&nbsp;Theerapat Chanamuangkon ,&nbsp;Pavena Chivatxaranukul ,&nbsp;Pairoj Linsuwanont","doi":"10.1016/j.identj.2025.03.022","DOIUrl":"10.1016/j.identj.2025.03.022","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>Cockle shells, which are discarded as waste by the food industry, have been used in medical fields. This study aimed to manufacture a newly developed cockle shell-derived bioceramic sealer (NDBS) and evaluate its physical and biological properties.</div></div><div><h3>Methods</h3><div>Cockle shell-derived tricalcium silicate (C-C₃S) was synthesized via the solid-state reaction technique and analysed for chemical composition and particle size. NDBS was prepared by mixing C-C₃S with specific additives. The chemical composition and surface morphology of fully set sealers were assessed using X-ray diffraction, Fourier-transform infrared spectroscopy, and scanning electron microscopy. Physical properties were tested according to International Organization for Standardization 6876 standards. For biological testing, both sealers were extracted and diluted for cytotoxicity and proliferation assays on human periodontal ligament cells using the MTT assay. Reverse transcription-quantitative polymerase chain reaction was performed to evaluate changes in proinflammatory (interleukin-6, interleukin-8, tumour necrosis factor-alpha-α) and mineralization (alkaline phosphatase) gene expression.</div></div><div><h3>Results</h3><div>C-C₃S was found to contain 55% tricalcium silicate with a particle size of 5.32 microns. Both fully set sealers contained tricalcium silicate and calcium silicate hydrate. They demonstrated acceptable flowability, setting time, film thickness, and radiopacity, although their solubility exceeded International Organization for Standardization limits. Both sealers maintained a pH above 7, with no significant difference in calcium release after 2 weeks. The MTT assay indicated improved cell viability with increasing dilution. Reverse transcription-quantitative polymerase chain reaction showed that both sealers showed a tendency to reduce proinflammatory gene expression. Both sealers showed a tendency to upregulate alkaline phosphatase gene expression.</div></div><div><h3>Conclusion</h3><div>Within the limitations of this study, it was shown that cockle shells can be used to manufacture NDBS, which demonstrated physical and biological properties comparable to those of iRoot SP.</div></div><div><h3>Clinical relevance</h3><div>This study highlights the potential of NDBS to be further developed as a root canal sealer.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 4","pages":"Article 100813"},"PeriodicalIF":3.2,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing a Smartphone Application for Detection of Oral Bite Force Using Artificial Intelligence","authors":"Jinxia Gao ,&nbsp;Huazheng Zhou ,&nbsp;Longjun Liu","doi":"10.1016/j.identj.2025.03.008","DOIUrl":"10.1016/j.identj.2025.03.008","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>The abnormal bite force plays a crucial role in triggering oral diseases. Currently, the field of bite force remains largely unexplored despite its immense potential. Previous studies have documented various devices for detecting bite force; however, there is a scarcity of corresponding visual applications to facilitate accurate diagnosis and treatment. Therefore, the purpose of this study is to design a smartphone application for intelligent detection of oral bite force.</div></div><div><h3>Methods</h3><div>This study has developed an intelligent program software for analyzing bite force detection, which encompassing modules such as introduction, environment setup, data reception and transmission, analysis processing, installation and uninstallation, as well as user instructions. Bluetooth wireless transmission has been utilized to transmit, store, and analyze bite simulation data.</div></div><div><h3>Results</h3><div>The developed application has presented sensor data in the form of single or multiple line graphs, assisting dentists in the diagnosis and treatment of oral diseases. Additionally, this program application provided feedback by detecting collected data and utilizing various output modes based on pre-set threshold values to prompt patients for self-correction, thereby achieving biofeedback regulation.</div></div><div><h3>Conclusion</h3><div>This intelligent application was designed to provide dentists with real-time monitoring, intelligent feedback, and effective intervention of bite force in their clinical practice. Clinical relevance: By achieving a dynamic equilibrium between bite force and the oral maxillofacial system, it aims to enhance disease diagnosis and treatment to a quantitative, controllable, and predictable level.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 4","pages":"Article 100799"},"PeriodicalIF":3.2,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of an Adult Periodontal Health Knowledge and Belief Questionnaire in Thai Adults","authors":"Patrika Bodhidatta ,&nbsp;Paswach Wiriyakijja ,&nbsp;Pimchanok Sutthiboonyapan","doi":"10.1016/j.identj.2025.04.001","DOIUrl":"10.1016/j.identj.2025.04.001","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>Periodontal diseases pose a significant oral health challenge, with many adults lacking adequate understanding of these conditions. This study aimed to develop and validate a questionnaire, designed for standardized assessment of periodontal health knowledge and beliefs in adults (ALPHABET).</div></div><div><h3>Methods</h3><div>The ALPHABET questionnaire, initially composed of 70 items focusing on periodontal health knowledge (ALPHA-K) and belief (ALPHA-B), underwent thorough development and validation via expert panel review. Structural validity of ALPHA-B was evaluated using confirmatory factor analysis, while convergent validity was confirmed by expected relationship between the scores of ALPHA-K and ALPHA-B, and reliability was assessed through internal consistency. A cross-sectional analysis involving 380 Thai adult dental patients examined the association between ALPHABET scores and patient types, as well as the association with oral health behaviours.</div></div><div><h3>Results</h3><div>After refinement, the final 40-item ALPHABET questionnaire showed a strong fit with the underlying model, confirming its structural validity. The correlations between the scores of ALPHA-K and ALPHA-B were proved its convergent validity. It also demonstrated high reliability, with Cronbach’s alpha coefficients exceeding 0.7, and favourable item-total correlations ranging from 0.406 to 0.773. Patients with a history of periodontal treatment scored significantly higher on all ALPHABET subscales compared to new patients (<em>P</em> &lt; .05). The logistic regression analysis demonstrated association of both knowledge and self-efficacy with both brushing and flossing behaviours.</div></div><div><h3>Conclusions</h3><div>To our knowledge, this questionnaire is the first to validate and assess periodontal health and belief in adults. It should serve as a valuable standardized tool that would potentially drive intervention and raise awareness of the disease and improve periodontal health outcomes.</div></div><div><h3>Clinical relevance</h3><div>This questionnaire should improve clinician insights into patient perspectives on periodontal disease so as to provide individualized oral health education, guiding tailored interventions for better outcomes.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 4","pages":"Article 100820"},"PeriodicalIF":3.2,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"A Patient-Centred Care of Dentist Scale: Perceptions of Dentists' in Thai Community Hospitals: A Multi-Group Analysis\".","authors":"Yutthana Khamnil, Surasak Kao-Iean, Pagaporn Pantuwadee Pisarnturakit","doi":"10.1016/j.identj.2025.02.002","DOIUrl":"https://doi.org/10.1016/j.identj.2025.02.002","url":null,"abstract":"<p><strong>Introduction and aims: </strong>Providing high-quality dental services at the primary care level requires a patient-centred approach. However, there is a lack of specific instruments to measure PCC in this context. This study aimed to develop and validate a tool to assess patient-centred care (PCC) among dentists working in Thailand's primary care settings and to examine how personal characteristics influence PCC.</p><p><strong>Methods: </strong>A set of 61 statements was developed for the Patient-Centred Care of Dentist Scale (PCCDS-D). Responses were collected using a Google Form. The validity and reliability of the scale were assessed through confirmatory factor analysis (CFA), exploratory factor analysis (EFA), Cronbach's alpha, and the intraclass correlation coefficient (ICC). Responses from dentists in large hospitals were compared with those from dentists in small hospitals. The influence of dentist attributes on PCC was examined.</p><p><strong>Results: </strong>The randomized samples for EFA and CFA included 754 and 305 dentists, respectively. The final version of the PCCDS-D contains 36 statements across seven components: dentist-patient relationship, disease-illness, integrated care, communication, shared information and decision-making, holistic, and empathy and anxiety management. The PCCDS-D demonstrated satisfactory reliability and validity, with good model fit and invariance across different dentist groups. The Cronbach's alpha and ICC were 0.94 and 0.93, respectively. The frequency of dentists practicing at primary care units (PCU) was found to influence the delivery of PCC.</p><p><strong>Conclusions: </strong>The PCCDS-D included 36 statements across seven domains and showed consistency among dentists in various-sized hospitals. It demonstrates robust reliability and validity. Additionally, experiences gained from practicing at PCU appear to impact the delivery of PCC.</p>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":"100763"},"PeriodicalIF":3.2,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Interdental Cleaning Frequency With Tooth Loss and Self-Rated Oral Health: A Cross-Sectional Study","authors":"Wei Zhou ,&nbsp;Yuhao Liu ,&nbsp;Tao Yin ,&nbsp;Mi He ,&nbsp;Changyun Fang ,&nbsp;Shifang Peng ,&nbsp;Yundong Liu","doi":"10.1016/j.identj.2025.03.012","DOIUrl":"10.1016/j.identj.2025.03.012","url":null,"abstract":"<div><h3>Aims</h3><div>This study investigated the associations of interdental cleaning frequency with lack of functional dentition (missing &gt;8 teeth) and self-rated oral health status.</div></div><div><h3>Methods</h3><div>Data from 14,154 participants aged 30 to 80 years in 2011 to 2020 US National Health and Nutrition Examination Survey were analysed using weighted multivariate Poisson regression.</div></div><div><h3>Results</h3><div>The prevalence rates of lacking functional dentition and poor self-rated oral health were 14.6% and 9.2%, respectively. 25.8% of the participants had never performed interdental cleaning, whereas 41.5% performed interdental cleaning 5 to 7 d/wk. When the never-performed interdental cleaning group was considered as reference group, the prevalence ratio and 95% confidence interval for the associations of interdental cleaning 1 to 4 and 5 to 7 d/wk with lack of functional dentition was 0.54 (0.39, 0.75) and 0.57 (0.42, 0.77), respectively, and significant interactions of interdental cleaning frequency with race, educational levels, and metabolic syndrome were observed. Notably, interdental cleaning exhibited a synergistic relationship with higher school education but an antagonistic relationship with Black ethnicity and metabolic syndrome in association with a lower prevalence of lacking functional dentition. The prevalence ratio and 95% confidence interval for interdental cleaning 1 to 4 and 5 to 7 d/wk for poor self-rated oral health was 0.54 (0.38, 0.77) and 0.43 (0.29, 0.63), respectively. Specifically, there was antagonistic interaction effect between dental visit intervals exceeding 6 months and interdental cleaning on self-rated oral health.</div></div><div><h3>Conclusions</h3><div>More frequent interdental cleaning was associated with more favourable self-rated oral health but not tooth loss. Higher education was synergistic but black ethnicity, metabolic syndrome, and long dental visit intervals were antagonistic with interdental cleaning in maintain natural teeth and better self-rated oral health. Interdental cleaning ≥5 d/wk cleaning, 6-monthly dental visits, and oral health education may decrease tooth loss and promote oral health.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 4","pages":"Article 100803"},"PeriodicalIF":3.2,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Matrix Stiffness Regulates the Osteogenic Differentiation of hPDLSCs via DNA Methylation","authors":"Rong Ding ,&nbsp;Chen Chen ,&nbsp;Ling Wang ,&nbsp;Yijie Wang ,&nbsp;Zhen Chai ,&nbsp;Siyu He ,&nbsp;Qianqian Zhang ,&nbsp;Shuli Cheng ,&nbsp;Rui Zou","doi":"10.1016/j.identj.2025.02.022","DOIUrl":"10.1016/j.identj.2025.02.022","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to examine the influence of matrix stiffness on osteogenic differentiation via epigenetic mechanisms in human periodontal ligament stem cells (hPDLSCs), with implications for understanding orthodontic tooth movement.</div></div><div><h3>Materials and Methods</h3><div>hPDLSCs were cultured on substrates with varying stiffness (soft and stiff). Dot blot and immunofluorescence techniques were employed to measure global DNA methylation levels. RT-qPCR and alkaline phosphatase (ALP) activity assays were conducted to assess differences in DNA methylation and osteogenic potential. Additionally, ELISA was used to quantify DNA methyltransferase content and activity.</div></div><div><h3>Results</h3><div>hPDLSCs on stiffer substrates exhibited increased 5-methylcytosine (5-mC) and higher global DNA methylation levels than those on soft substrates. With increased matrix stiffness, DNMT3A and DNMT3B mRNA expression levels rose. hPDLSCs on stiff matrices also showed elevated DNMT3B enzyme content and osteogenic activity. When global DNA methylation was reduced, mRNA levels of RUNX2, ALP, and Col-1 decreased, along with a notable reduction in ALP staining intensity in the inhibitor group.</div></div><div><h3>Conclusions</h3><div>Matrix stiffness is positively associated with global DNA methylation, with DNMT3B likely mediating this regulation in hPDLSCs. Furthermore, DNA methylation levels are positively linked to the osteogenic capability of hPDLSCs.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 4","pages":"Article 100783"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CTSK as a Collagen Degradation Marker Induces Gingival Recession During High-Force Orthodontic Tooth Movement","authors":"Yanfang Wang ,&nbsp;Yili Xu ,&nbsp;Yutong Lu ,&nbsp;Xinying Su ,&nbsp;Yonghua Lei","doi":"10.1016/j.identj.2025.03.019","DOIUrl":"10.1016/j.identj.2025.03.019","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>Gingival recession is a common complication of orthodontic treatment that affects both aesthetics and periodontal health. While traditionally associated with bone resorption, recent research suggests that Cathepsin K (CTSK) play a significant role in collagen fibre degradation within periodontal connective tissues. This study combines animal experiments and clinical research to investigate whether CTSK plays a role in the process of gingival recession during orthodontic tooth movement (OTM).</div></div><div><h3>Methods</h3><div>An OTM model was created using the maxillary first molar in mice. Differences in gingival tissue thickness and height between experimental and control groups were statistically analysed. Additionally, in the clinical study, CTSK expression in gingival crevicular fluid (GCF) was assessed. CTSK mRNA expression in gingival crevicular fluid was evaluated in orthodontic patients, comparing healthy and gingival recession groups.</div></div><div><h3>Results</h3><div>High-force OTM significantly decreased the thickness and height of mesial gingival tissues (<em>P</em> &lt; .005). In the gingival recession group, the number of cells within the region of interest (ROI) decreased, while the number of CTSK+ cells increased significantly (<em>P</em> &lt; .0005). RT-qPCR analysis showed that CTSK mRNA expression in GCF of gingival recession patients was significantly higher than in the control group (<em>P</em> &lt; .05).</div></div><div><h3>Conclusion</h3><div>High-force orthodontic tooth movement induced gingival recession in mice. The results of the animal experiment suggested that CTSK contributes to collagen fibre degradation in gingival connective tissue, leading to recession. Studies of human GCF have further supported the role of CTSK as a marker of collagen degradation in gingival recession.</div></div><div><h3>Clinical relevance</h3><div>These findings may offer new insights for the clinical management of complications such as \"black triangles\" following orthodontic treatment.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 4","pages":"Article 100810"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Serum Albumin and Periodontitis Across Disease Subgroups: A Cross-Sectional Study","authors":"Junwei Xiang ,&nbsp;Yuhang Cai ,&nbsp;Qingping Yu,&nbsp;Zhongqing Zhu,&nbsp;Yuanyin Wang,&nbsp;Ran Chen","doi":"10.1016/j.identj.2025.03.017","DOIUrl":"10.1016/j.identj.2025.03.017","url":null,"abstract":"<div><h3>Purpose</h3><div>This study examines the association between serum albumin (sALB) levels and periodontitis severity, focusing on subgroup differences and nonlinear relationships. It extends previous findings, which were limited to chronic kidney disease (CKD) patients.</div></div><div><h3>Materials and methods</h3><div>This cross-sectional study utilized data from 8352 participants in the NHANES 2009 to 2014 survey cycles. sALB and periodontitis were the exposure and outcome variables. Logistic regression models and restricted cubic spline curves were used to investigate the relationship between the two. Additionally, subgroup and interaction analyses were conducted to assess the stability of the findings. All statistical analyses considered the complex survey design.</div></div><div><h3>Results</h3><div>A significant negative association was observed between sALB and periodontitis status (aOR 0.94, 95% confidence intervals: 0.93-0.96, <em>P</em> value &lt;.001). The strength of this association may be influenced by participants’ gender, CKD status, and hypertension status. Among participants with sALB levels below 35 g/L (defined as hypoalbuminemia), no significant association with periodontitis was observed, even in those with CKD. Restricted cubic spline analysis demonstrated an inverted U-shaped relationship between sALB levels and periodontitis, with a threshold effect at 38 g/L. Above this inflection point, higher sALB levels were significantly associated with a lower prevalence of periodontitis (<em>P</em> &lt; .001).</div></div><div><h3>Conclusions</h3><div>ALB levels were inversely associated with moderate and severe periodontitis, with an inverted U-shaped relationship observed in this study. The differences among subgroups warrant further research.</div></div><div><h3>Clinical relevance</h3><div>Maintaining appropriate sALB levels may be beneficial for periodontal health. Further research is needed to confirm its role in periodontitis prevention and treatment.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 4","pages":"Article 100808"},"PeriodicalIF":3.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}