Effects of Xylitol-laced Sweets on the Accumulation of Dental Plaque : A Systematic Review and Meta-Analysis

IF 3.2 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

International dental journal Pub Date : 2025-06-27 DOI:10.1016/j.identj.2025.100842

Mohammad Mostafazadehbakhtiyary , Sara Majidinia , MohammadHassan Sohouli , Hossein Chalakinia , Atefeh Sadat Langari , Sara Ziaaddini , Reza Shakiba , Shayan Yousefi

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引用次数: 0

Abstract

Background

This meta-analysis was carried out in order to assess the effects of xylitol-laced sweets on the accumulation of dental plaque biofilm.

Methods

Using predetermined keywords, a systematic search was conducted using the original databases published until July 2024 on randomized controlled trials that evaluated the effect of xylitol-laced sweets on the accumulation of dental plaque. The random-effects model was used to obtain the 95% confidence intervals and the pooled weighted mean difference.

Results

A quantitative meta-analysis of 13 treatment arms of the included studies showed that xylitol-laced sweetssignificantly decreased the plaque index (PI) (WMD: −0.41, 95% CI: −0.62, −0.20, P < .001) and the quantity of plaque accumulation (WMD: −7.46 mg, 95% CI: −13.38, −1.53, P = .014) compared with thecontrol groups. The subgroup analysis showed that xylitol causes a greater decrease in plaque accumulation (PI and amount of plaque) in the dose of interventions ≤20 g compared to >20 g and also during the intervention <4 weeks compared to ≥4 weeks . In addition, the subgroup analysis shows a greater effect on PI reduction in those ≤ 18 years of age.

Conclusions

Our findings show the potentially beneficial and significant effects of xylitol-laced sweets either in gummy or candy forms, on reducing plaque accumulation.

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含木糖醇的糖果对牙菌斑积累的影响：一项系统综述和荟萃分析

本荟萃分析是为了评估木糖醇糖果对牙菌斑生物膜积累的影响。方法采用预先确定的关键词，对截至2024年7月发表的原始数据库进行系统检索，以评估木糖醇糖果对牙菌斑积累的影响。随机效应模型用于获得95%置信区间和合并加权平均差。结果纳入研究的13个治疗组的定量荟萃分析显示，添加木糖醇的糖果显著降低斑块指数（PI） (WMD: - 0.41, 95% CI: - 0.62, - 0.20, P <；.001)和斑块堆积数量（WMD:−7.46 mg, 95% CI:−13.38,−1.53,P = 0.014）。亚组分析显示，木糖醇在干预剂量≤20g时比干预剂量≤20g时更能降低斑块积累（PI和斑块数量），在干预剂量≥4周时也比干预剂量≥4周时更能降低斑块积累（PI和斑块数量）。此外，亚组分析显示，在≤18岁的患者中，PI降低的效果更大。结论我们的研究结果表明，含有木糖醇的软糖或糖果对减少斑块积累具有潜在的有益和显著的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International dental journal 医学-牙科与口腔外科

CiteScore

4.80

自引率

6.10%

发文量

159

审稿时长

63 days

期刊介绍： The International Dental Journal features peer-reviewed, scientific articles relevant to international oral health issues, as well as practical, informative articles aimed at clinicians.