International dental journal最新文献

{"title":"An Oxygen-Releasing Mouthwash Reduces Porphyromonas gingivalis Biofilm and Suppresses fimA and hagA Expression","authors":"Fatemah M. AlAhmari ,&nbsp;Rhodanne Nicole A. Lambarte ,&nbsp;Terrence S. Sumague ,&nbsp;Mary Grace B. Vigilla ,&nbsp;Marwa Y. Shaheen ,&nbsp;Sumaiah Ajlan ,&nbsp;Lamees R. Alssum ,&nbsp;Amani M. Basudan ,&nbsp;Abdurahman A. Niazy","doi":"10.1016/j.identj.2026.109432","DOIUrl":"10.1016/j.identj.2026.109432","url":null,"abstract":"<div><h3>Introduction and Aims</h3><div><em>Porphyromonas gingivalis</em> is a key periodontal pathogen whose biofilm and virulence limit the effectiveness of mouthwashes such as chlorhexidine (CHX). This study evaluated the antibacterial, antibiofilm and virulence effects of an oxygen-releasing mouthwash against <em>P. gingivalis</em>, complemented by in silico docking and cytotoxicity testing on human oral fibroblasts.</div></div><div><h3>Methods</h3><div><em>P. gingivalis</em> ATCC 33277 was grown anaerobically. Minimum inhibitory (MIC), bactericidal (MBC) and biofilm inhibitory concentrations (MBIC) were determined by resazurin-based microdilution and crystal violet biofilm assays, with 0.12% CHX as control. Biofilm structure and viability were analysed by confocal microscopy. Quantitative PCR measured expression of 6 virulence- and biofilm-associated genes. Molecular docking of sodium perborate to protein targets used AutoDock GNINA. Fibroblast cytotoxicity (ISO 10993-5 threshold ≥70% viability) was evaluated over 30 min to 24 h.</div></div><div><h3>Results</h3><div>Bluem mouthwash showed concentration-dependent inhibition of <em>P. gingivalis</em> with minimum inhibitory (MIC), bactericidal (MBC) and biofilm inhibitory concentrations (MBIC) values of 0.78%, 1.56% and 3.12%, respectively. At 0.78%, biofilm biomass decreased to around 45% and at concentrations of ≥3.12% was reduced to ≤20%, with greater reduction than 0.12% CHX. Confocal imaging showed reduced biomass and thickness with a predominance of nonviable cells at higher concentrations. Bluem mouthwash was associated with downregulation of virulence-related genes, with <em>fimA</em> and <em>hagA</em> expression reduced at concentrations ≥0.78%, whereas 0.12% CHX increased <em>fimA</em> expression. Molecular docking predicted moderate binding affinities of sodium perborate with key virulence proteins, including kgp and mfa1. Bluem concentrations ≤0.78% maintained noncytotoxic fibroblast viability, while ≥1.56% and 0.12% CHX were cytotoxic across all tested periods.</div></div><div><h3>Conclusion</h3><div>The oxygen-releasing mouthwash inhibited <em>P. gingivalis</em> biofilm formation, modulated virulence-associated gene expression and showed a wider noncytotoxic range on oral periodontal fibroblasts than chlorhexidine.</div></div><div><h3>Clinical Relevance</h3><div>These findings on an oxygen-releasing mouthwash may help guide concentration selection and inform its potential adjunctive use in periodontal protocols, but clinical outcome studies are still needed before routine use can be recommended.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"76 2","pages":"Article 109432"},"PeriodicalIF":3.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146165249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral Small Vessel Disease as a Novel Risk Indicator for Periodontitis Progression","authors":"Shaobo Han ,&nbsp;Xinyu Chen ,&nbsp;Fei Li ,&nbsp;Xingdong Chen ,&nbsp;Mei Cui ,&nbsp;Katherine Chiu Man Leung ,&nbsp;Yanfeng Jiang ,&nbsp;Edward Chin Man Lo ,&nbsp;Haixia Lu","doi":"10.1016/j.identj.2026.109414","DOIUrl":"10.1016/j.identj.2026.109414","url":null,"abstract":"<div><h3>Background</h3><div>To assess whether cerebral small vessel disease (CSVD) is a risk indicator for accelerated periodontitis progression.</div></div><div><h3>Materials and methods</h3><div>In this prospective cohort study, longitudinal data from 458 participants in the Taizhou Imaging Study (TIS) were analysed. CSVD was defined by the presence of lacunes (LAC), white matter hyperintensities (WMH), and cerebral microbleeds (CMB) on brain magnetic resonance imaging (MRI). Periodontitis progression was reflected by increases in mean probing depth (ΔmeanPD) and clinical attachment loss (ΔmeanCAL), number of teeth lost (ΔTL) and teeth with interproximal attachment loss progression exceeding 3 mm (Tooth_CAL3). Univariable and multivariable analyses evaluated the associations between CSVD markers and periodontitis progression. Two sensitivity analyses were also conducted, one was a model that excluded the variable toothbrushing frequency after multiple imputation, and the other was a conventional model that incorporated variables such as sociodemographic, behavioural, and general health risk indicators.</div></div><div><h3>Results</h3><div>Multivariable analysis showed CSVD was positively associated with ΔmeanPD (<em>P</em> &lt; .01) and ΔmeanCAL (<em>P</em> &lt; .01); WMH was positively associated with ΔmeanPD (<em>P</em> = .01), ΔmeanCAL (<em>P</em> &lt; .01), and Tooth_CAL3 (<em>P</em> &lt; .01); CMB was positively associated with ΔmeanCAL (<em>P</em> = .03). Sensitivity analyses confirmed the robustness of the results.</div></div><div><h3>Conclusions</h3><div>CSVD may serve as a risk indicator for an accelerated progression of periodontitis in older adults. The specific CSVD markers of WMH and CMB show significant associations with worsening clinical periodontal parameters.</div></div><div><h3>Clinical significance</h3><div>This study emphasises the critical importance of integrating regular periodontal surveillance and preventive care into the clinical management of patients with CSVD.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"76 2","pages":"Article 109414"},"PeriodicalIF":3.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146165198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Practice Guidelines on the Diagnosis and Treatment of Halitosis","authors":"Xiaodi Shang ,&nbsp;Xinxiao Chen ,&nbsp;Chunxu Lv ,&nbsp;Zhen Wang ,&nbsp;Bin Chen ,&nbsp;Jinlong Shao ,&nbsp;Ye Liang ,&nbsp;Aimei Song ,&nbsp;Hongmei Guo ,&nbsp;Yang Yu ,&nbsp;Hongrui Liu ,&nbsp;Mi Du ,&nbsp;Jin Zhang ,&nbsp;Wenyan Kang ,&nbsp;Jianhua Li ,&nbsp;Baojin Ma ,&nbsp;Fuhua Yan ,&nbsp;Yaping Pan ,&nbsp;Faming Chen ,&nbsp;Yan Xu ,&nbsp;Shaohua Ge","doi":"10.1016/j.identj.2026.109436","DOIUrl":"10.1016/j.identj.2026.109436","url":null,"abstract":"<div><div>With growing awareness of oral health and rising social expectations, the management of halitosis has attracted increasing attention, as fresh breath is essential for social etiquette and personal image. Due to the diverse origins and varying clinical manifestations of halitosis, treatment approaches differ significantly. Recent advancements have facilitated the development of more refined diagnostic tools and therapeutic methods. Based on current clinical evidence and practice, a consensus framework has been established to guide the management of halitosis. This consensus systematically outlines the prevalence and classification of halitosis, reviews its aetiology and pathogenesis, and details evidence-based diagnostic methods. Notably, it proposes tailored treatment strategies aligned with specific etiological factors. The goal is to promote the standardization, precision, and optimization of halitosis diagnosis and treatment in clinical practice.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"76 2","pages":"Article 109436"},"PeriodicalIF":3.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146179443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SERPINA1 as a Shared Biomarker in Periodontitis and Oral Squamous Cell Carcinoma","authors":"Jingkun Zhang ,&nbsp;Guangwei Chen ,&nbsp;Qi Wang ,&nbsp;Yali Chi ,&nbsp;Guoxu Han","doi":"10.1016/j.identj.2025.109378","DOIUrl":"10.1016/j.identj.2025.109378","url":null,"abstract":"<div><h3>Objective</h3><div>Periodontitis (PD) and oral squamous cell carcinoma (OSCC) frequently co‑occur in clinical populations. However, shared molecular determinants that could support risk assessment across diseases remain insufficiently defined. This study aimed to identify shared diagnostic biomarkers and potential mechanisms linking PD and OSCC using integrated bioinformatics and machine learning.</div></div><div><h3>Methods</h3><div>PD and OSCC transcriptomic datasets were analysed to identify shared programmed cell death-related biomarkers using differentially expressed genes (DEGs), WGCNA and multiple machine learning algorithms (LASSO, Random Forest, GLM). Diagnostic performance was validated in external cohorts via ROC analysis, while immune landscapes and cellular interactions were characterised using CIBERSORT and single-cell analysis. At the cellular level, we evaluated SERPINA1 expression in an LPS-induced periodontal inflammation model and conducted siRNA-mediated knockdown in CAL27 oral cancer cells to examine its effects on proliferation, migration and invasion.</div></div><div><h3>Results</h3><div>Transcriptomic analyses of PD and OSCC revealed a shared immune-inflammatory signature with enrichment of programmed cell death pathways. SERPINA1 was consistently prioritised by LASSO, random forest and GLM and showed strong diagnostic performance across training and external validation cohorts (AUC &gt; 0.8). CIBERSORT indicated remodelling of the immune microenvironment associated with SERPINA1 expression, with positive correlations to macrophage and neutrophil abundance. Single-cell analyses localised SERPINA1 to myeloid populations and suggested putative crosstalk with the pro-inflammatory mediator interleukin-1β (IL-1β). In the periodontal inflammation model, SERPINA1 expression was significantly upregulated upon LPS stimulation alongside increased inflammatory mediators such as IL-8 and IL-1β. In contrast, SERPINA1 knockdown in oral cancer cells led to reduced proliferative, migratory and invasive capacities.</div></div><div><h3>Conclusions</h3><div>SERPINA1 emerges as a cross‑disease candidate biomarker linking chronic periodontal inflammation and oral cancer biology. The integrative framework provides a transparent roadmap for identifying clinically meaningful, reproducible biomarkers across oral diseases, going forwards.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"76 2","pages":"Article 109378"},"PeriodicalIF":3.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NLRP12 Alleviated Periodontal Destruction via Suppressing Nuclear Factor Kappa-B Signalling Pathway","authors":"Shuangshuang Xu ,&nbsp;Weiping Wang ,&nbsp;Yuhui Sun,&nbsp;Juefei Wu,&nbsp;Wenting Zhang,&nbsp;Gang Ding","doi":"10.1016/j.identj.2026.109417","DOIUrl":"10.1016/j.identj.2026.109417","url":null,"abstract":"<div><h3>Objective</h3><div>Periodontal ligament stem cells (PDLSCs) have been shown to demonstrate robust tissue regeneration capabilities. NACHT, leucine-rich repeat and PYD-containing 12 (NLRP12) could exerts negative inflammatory regulatory role in various pathological contexts. The effects of NLRP12 on the inflammatory responses and osteogenesis of PDLSCs under inflammatory microenvironment and underlying mechanisms remain unknown.</div></div><div><h3>Methods</h3><div>PDLSCs were isolated, cultured, and characterized, and the expression level of NLRP12 was analysed following lipopolysaccharide (LPS) treatment. Then, <em>NLRP12</em> was overexpressed in PDLSCs via lentivirus transfection. Inflammatory factors were detected by quantitative real-time polymerase chain reaction, osteogenic markers were quantified using quantitative real-time polymerase chain reaction, Western blot, and the capability of osteogenesis was assessed through alkaline phosphatase staining and alizarin red staining. The underlying signalling pathways were examined by Western blot analysis and agonist treatment. Moreover, rat periodontitis models established by ligature method were used to evaluate the regulatory effects of NLRP12 on PDLSC-mediated anti-inflammation and periodontal regeneration <em>in vivo</em>.</div></div><div><h3>Results</h3><div>PDLSCs exhibited mesenchymal stem cell characteristics with multilineage differentiation. NLRP12 was downregulated in LPS-treated PDLSCs. LPS upregulated inflammatory factor expression while downregulating anti-inflammatory factors and suppressing PDLSCs’ osteogenic differentiation, which were reversed by <em>NLRP12</em> overexpression. Mechanistically, nuclear factor kappa-B signalling pathway participated in these processes. Furthermore, microscopic computed tomography scanning, histological analysis, and immunohistochemical staining revealed that NLRP12 ameliorated inflammation and enhanced periodontal regeneration in periodontitis animal models.</div></div><div><h3>Conclusions</h3><div>NLRP12 suppressed inflammatory responses while enhancing osteogenic differentiation of PDLSCs via downregulating the activation of the nuclear factor kappa-B pathway, indicating that NLRP12 is a latent target for enhancing PDLSCs-based periodontal tissue regeneration.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"76 2","pages":"Article 109417"},"PeriodicalIF":3.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exopolysaccharides of Streptococcus mutans Enhance Oral Colonisation and Drug Tolerance in Helicobacter pylori","authors":"Yujia Hao ,&nbsp;Yuqiu Huang ,&nbsp;Ruonan Chen ,&nbsp;Yuqing Li ,&nbsp;Xiaojing Huang","doi":"10.1016/j.identj.2026.109405","DOIUrl":"10.1016/j.identj.2026.109405","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>The oral cavity is an extragastric reservoir for <em>Helicobacter pylori</em> (<em>H. pylori</em>), preventing its gastric eradication and causing recurrence. However, the oral environment is not ideal for <em>H. pylori</em>, and the factors facilitating oral <em>H. pylori</em> survival and colonisation are unclear. We explored how exopolysaccharides (EPSs), the fundamental building blocks of <em>Streptococcus mutans</em> (<em>S. mutans</em>) biofilms, affect <em>H. pylori</em> colonisation and drug tolerance in the oral cavity.</div></div><div><h3>Methods</h3><div>The EPS contents of 3 <em>S. mutans</em> biofilms (UA159, UA159Δ<em>gtfB</em>, and UA159Δ<em>gtfBC</em>) were determined via confocal laser scanning microscopy (CLSM). A coculture system of the <em>H. pylori</em> Sydney strain (SS1) and the 3 biofilms was established. The bacterial morphology and adhesive forces of the coculture systems were detected by scanning electron microscopy (SEM) and atomic force microscopy (AFM), respectively. CLSM observations confirmed the ability of glucosyltransferases (Gtfs) from <em>S. mutans</em> to form EPSs around SS1. The tolerance of SS1 to 2 representative antibiotics in the presence of EPSs was confirmed via colony-forming unit (CFU) counting and <em>in vivo</em> experiments.</div></div><div><h3>Results</h3><div>As the EPS content of the <em>S. mutans</em> biofilms increased, both the adhesive forces between SS1 and the <em>S. mutans</em> biofilms and the number of colonised SS1 cells increased. We extracted active Gtfs from UA159 and confirmed that Gtfs synthesised EPSs around SS1. The EPSs gradually accumulated over time, eventually encapsulating SS1. Both <em>in vitro</em> and <em>in vivo</em> experiments confirmed that <em>S. mutans</em> EPSs help protect SS1 against amoxicillin or clarithromycin, potentially confounding gastric lesion outcomes.</div></div><div><h3>Conclusions</h3><div><em>S. mutans</em> biofilms mediate the adhesion, colonisation, and antibiotic tolerance of oral <em>H. pylori</em> via Gtf-driven EPS biosynthesis.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"76 2","pages":"Article 109405"},"PeriodicalIF":3.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Burden of Lip and Oral Cavity Cancer Attributable to Alcohol Use in 204 Countries and Regions","authors":"Xiangqian Meng,&nbsp;Jie Zhang","doi":"10.1016/j.identj.2025.109359","DOIUrl":"10.1016/j.identj.2025.109359","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>Lip and oral cavity cancer is a significant global health burden. Alcohol use is a major independent risk factor. This study aims to comprehensively quantify the global disease burden of lip and oral cavity cancer attributable to alcohol use from 1990 to 2019 and to identify temporal, geographical, and gender-specific patterns.</div></div><div><h3>Methods</h3><div>This study aims to estimate the trends in age-standardized death rates (ASDR) and disability-adjusted life years (DALYs) for lip and oral cancer attributable to alcohol use in 204 countries and 21 regions. Additionally, we will calculate the estimated annual percentage changes (EAPC) for these trends.</div></div><div><h3>Results</h3><div>Between 1990 and 2019, the global number of deaths and DALYs for lip and oral cancers attributable to alcohol use increased. In 2019, Central Europe had the highest ASDR per 100,000 for lip and oral cancer due to alcohol (EAPC = 1.53, 95% confidence interval [CI]: 1.24-1.83), while East Asia (EAPC = 2.66, 95% CI: 2.32-3.00). Eastern Europe had the highest DALY rate per 100,000 individuals (46.60), and East Asia showed the most significant increase (EAPC = 2.48, 95% CI: 2.15-2.81). Across all measures – including deaths, DALYs, ASDR, and DALY rates – men had considerably higher values than women in both 1990 and 2019.</div></div><div><h3>Conclusion</h3><div>The absolute quantity of lip and oral cancer attributable to alcohol consumption was continuously increasing. Between 1990 and 2019. The findings reveal pronounced geographical disparities, with a particularly heavy burden in Central and Eastern Europe, and the most rapid increase observed in East Asia. A striking gender disparity persists, with males bearing a substantially higher burden than females.</div></div><div><h3>Clinical relevance</h3><div>Healthcare professionals should prioritize screening and interventions for alcohol use, particularly among high-risk populations in regions with increasing burden, to reduce the incidence and mortality of lip and oral cavity cancer.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"76 2","pages":"Article 109359"},"PeriodicalIF":3.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145974256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acceptability and Usability of a Digital Medicines Tool for Dental Practitioners in four Southeast Asian Countries","authors":"Leanne Teoh ,&nbsp;Ruby Biezen ,&nbsp;Marietta Taylor ,&nbsp;Nadia Kaunein ,&nbsp;Wendy Thompson ,&nbsp;Charlene Goh ,&nbsp;Jacob Chew ,&nbsp;Yuniardini Septorini Wimardhani ,&nbsp;Mohd Hafiz Arzmi ,&nbsp;Wan NurHazirah Wan Ahmad Kamil ,&nbsp;Sireerat Sooampon ,&nbsp;Benjar Issaranggun Na Ayuthaya ,&nbsp;Michael McCullough","doi":"10.1016/j.identj.2025.109361","DOIUrl":"10.1016/j.identj.2025.109361","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>Antimicrobial resistance is a global public health emergency and a prominent issue in Southeast Asia. There is also a lack of dental-specific drug resources to assist with medication management for dentists. Our dental-specific decision support tool, MIMS Drugs4dent, was developed to assist Australian dentists optimize their prescribing. The aim of this study was to trial MIMS Drugs4dent for acceptability and usability with dental practitioners in Indonesia, Malaysia, Singapore, and Thailand.</div></div><div><h3>Methods</h3><div>This was a cross-sectional study of MIMS Drugs4dent with dental practitioners in Indonesia, Malaysia, Singapore, and Thailand. Dental practitioners were provided access to MIMS Drugs4dent for 1 month. After the intervention period, participants completed an online survey that assessed their perceptions of the tool. The primary outcome was the acceptability and usability of MIMS Drugs4dent, using the Framework for Acceptability and System Usability Scale, respectively. The secondary outcome was to determine the resources used by dental practitioners for drug information. Descriptive statistics and thematic analysis were used for quantitative and qualitative data analysis, respectively.</div></div><div><h3>Results</h3><div>From January to June 2025, 30 dentists from each country participated. Most participants (93.4% and 94.2%) agreed or strongly agreed that MIMS Drugs4dent can improve their ability to prescribe according to guidelines and access dental-relevant drug information, respectively. Most participants (88.3% and 82.5%) agreed or strongly agreed that MIMS Drugs4dent was easy to use and that information could be located quickly. However, participants preferred a local drug database and a mobile-rendered version to improve usability. A wide range of sources (n = 62) were reported to be used for medicines information.</div></div><div><h3>Conclusion</h3><div>MIMS Drugs4dent had high acceptability and usability in this study. With adaptation using country-specific localised drug databases, the tool has potential for use in dentistry in these countries. The study underscores the importance of including dentistry in broader digital health strategies.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"76 2","pages":"Article 109361"},"PeriodicalIF":3.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145974238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A High-Fidelity Framework for 3D Dental Crown Reconstruction Using Intraoral Images","authors":"Ni Liao ,&nbsp;Xinyu Zhang ,&nbsp;Wenkang Chen ,&nbsp;Xuejun Zhang ,&nbsp;Shuixue Mo","doi":"10.1016/j.identj.2025.109379","DOIUrl":"10.1016/j.identj.2025.109379","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>This study aimed to develop a novel framework, DenGaussDiff, which employed three-dimensional (3D) Gaussian neural fields and diffusion priors for precise dental crown reconstruction from 5 intraoral images.</div></div><div><h3>Methods</h3><div>This study collected 1000 clinical cases with 5 intraoral images and paired intraoral scanning (IOS) models and a public dataset was employed. First, images were segmented and enhanced to improve input quality. Next, 3D basic representation of the crowns was constructed using integrated camera pose estimation and an optimised ControlNet++ model. Then, a learnable neural representation was introduced and multiscale Gaussian rendering was applied to optimise the 3D crown representation. Finally, the Iterative Closest Point (ICP) algorithm was used for registration with IOS models.</div></div><div><h3>Results</h3><div>On our dental crown dataset, DenGaussDiff outperformed other reconstruction methods, with a 1.33% increase in Peak Signal-to-Noise Ratio (PSNR), a 3.9% increase in Structural Similarity Index (SSIM) and a 4.3% reduction in Learned Perceptual Image Patch Similarity (LPIPS). The point cloud registration results demonstrated a high-precision match between the reconstructed 3D crown model and IOS model. On the public dataset, DenGaussDiff achieved excellent performance among various evaluation indicators in dental plaque, tooth absence and tooth decay. Each key component of our framework was shown to be critical for precise reconstruction in ablation study.</div></div><div><h3>Conclusion</h3><div>The DenGaussDiff framework provides precise 3D dental crown reconstructions from sparse intraoral images, suggesting its potential in orthodontic diagnosis and monitoring. This further facilitates the clinical implementation of digital dentistry.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"76 2","pages":"Article 109379"},"PeriodicalIF":3.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Oral Health Care for Frail, Community-Dwelling Older People: Exploring Barriers and Facilitators for Interprofessional Collaboration","authors":"Mees H.S. de Jong ,&nbsp;Katarina Jerković-Ćosić ,&nbsp;Monique H. van der Veen ,&nbsp;Vanessa R.Y. Hollaar ,&nbsp;Linet F. Weening-Verbree ,&nbsp;Lea Kragt ,&nbsp;Seline (W.E.) Kok ,&nbsp;Fred R. Rozema ,&nbsp;Claar D. van der Maarel-Wierink","doi":"10.1016/j.identj.2025.109346","DOIUrl":"10.1016/j.identj.2025.109346","url":null,"abstract":"<div><h3>Introduction</h3><div>Oral health is an important aspect of overall well-being, especially for frail older people, who are increasingly ageing in place. As this population with associated complex health care needs grows, integrated and collaborative oral health care becomes more urgent. Despite its importance, oral health is often overlooked in both practice and policy. This study aims to identify barriers and facilitators at the micro, meso, and macro levels to improve interprofessional collaboration for oral health care of frail, community-dwelling older people.</div></div><div><h3>Methods</h3><div>This qualitative study was conducted in the Netherlands and comprised two data collection methods: six semistructured interviews and five discipline-specific focus group discussions, involving a total of 38 health care professionals. Each focus group consisted of professionals from a single discipline, including oral health care professionals, general practitioners, home care professionals, pharmacists, and public health professionals. Participants represented health care professionals both within nationally recognized integrated geriatric care networks and those not yet participating in such networks. Data were analysed inductively using thematic analysis in Atlas.ti.</div></div><div><h3>Results</h3><div>At the micro level, barriers included limited awareness, knowledge, and prioritization of oral health, unclear responsibilities, time constraints, and inconsistent referral pathways. At the meso level, participants reported insufficient standardized protocols, lack of interprofessional education, and poor digital integration of medical record systems. At the macro level, key issues were inadequate funding and reimbursement, fragmented policies, and limited support for home-based oral care. Facilitators at the micro and meso level included raising awareness and interprofessional education, practical tools and clear referral pathways, improved ICT systems, and appointing regional coordinators to strengthen multidisciplinary collaboration. At the macro level, national guidance and structural financial incentives were viewed as crucial for sustainable integration.</div></div><div><h3>Conclusion</h3><div>In conclusion, this study, identified critical barriers and facilitators for effective interprofessional collaboration and better oral health care for community-dwelling frail older people at the micro, meso, and macro levels. Improvement requires increasing awareness and education among professionals, better integration of oral health care in multidisciplinary care networks, shared electronic medical record systems, and adequate reimbursement. These findings should inform guidelines and be validated through implementation studies.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"76 2","pages":"Article 109346"},"PeriodicalIF":3.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145883844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}