International dental journal最新文献

{"title":"Piezo1 Promotes Odontogenic Differentiation of Dental Pulp Stem Cells Under Stress Conditions.","authors":"Xiaxia Wang, Shaojie Dong, Qianqian Dong, Xuefei Sun","doi":"10.1016/j.identj.2025.01.018","DOIUrl":"https://doi.org/10.1016/j.identj.2025.01.018","url":null,"abstract":"<p><strong>Objectives: </strong>Mechanical stimuli signals regulate the odontogenic differentiation of dental pulp stem cells (DPSCs), but they are difficult to apply in clinical treatment. Piezo1, a specific mechanically activated ion channel that mediates mechanical transduction, may serve as a potential target for regulating mechanical signals. In the present study, we aimed to investigate the function and potential molecular mechanisms of Piezo1 in the odontogenic differentiation of DPSCs.</p><p><strong>Methods: </strong>Piezo1 expression in human dental pulp and DPSCs was detected by immunofluorescence or immunohistochemistry (IHC). The mechanotransduction of Piezo1 ion channels in DPSCs was determined by fluid shear stress (FSS) detection of calcium fluorescence intensity and whole-cell patch clamp detection. The role of Piezo1 in the odontogenic differentiation of DPSCs was detected by alizarin red staining and Western blotting under hydrostatic pressure (HP). The expression and distribution of the downstream molecules Piezo1, CaN, and YAP were detected through coimmunoprecipitation (co-IP), immunocytochemistry (ICC), and Western blot analysis.</p><p><strong>Results: </strong>The Piezo1 protein was positively expressed in human dental pulp samples, especially in the odontoblast layer. Increased Piezo1 expression was also detected after odontogenic differentiation of DPSCs in vitro. The fluorescence intensity of intracellular calcium ions (Ca²⁺i) increased rapidly with treatment with FSS or Yoda1 (a Piezo1-specific agonist) but did not significantly change after treatment with GsMTx4 (a Piezo1 antagonist) or BAPTA (an extracellular calcium ion chelating agent). A whole-cell patch clamp was used to record the inward current induced by mechanical stimulation of the DPSCs. After Yoda1 treatment, the peak current increased, but the currents nearly completely disappeared after pretreatment with GsMTx4. In addition, we found that blocking CaN or YAP reversed the ability of HP to promote DPSC odontogenic differentiation. Co-IP and ICC revealed that the CaN and YAP proteins colocalized and bound to each other in DPSCs.</p><p><strong>Conclusions: </strong>These findings indicated that the Piezo1 ion channel mediates the mechanical transduction of DPSCs. In addition, Piezo1 promotes odontogenic differentiation of DPSCs through the Ca²⁺/CaN/YAP signalling axis under HP, which provides effective intervention targets for mechanical stimulation-mediated regulation of reparative dentin and vital pulp preservation.</p>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poor Oral Hygiene: A Hidden Risk Factor for Helicobacter pylori Infection.","authors":"Xiao Zhao, Xiao She, Haiyan Yang, Ziqin Zeng, Weicheng Zhi, Yan Jing, Lei Dong, Jun Gong, Haitao Guan, Ping Zhao","doi":"10.1016/j.identj.2025.01.001","DOIUrl":"https://doi.org/10.1016/j.identj.2025.01.001","url":null,"abstract":"<p><strong>Background: </strong>Helicobacter pylori (H. pylori) initially enters the human body through the mouth. The correlation between oral health and H. pylori infection status remains a topic of debate in the scientific literature. To elucidate the relationships between H. pylori infection and oral hygiene status and habits, we performed a cross-sectional study among dyspeptic patients.</p><p><strong>Methods: </strong>Data were collected from 362 subjects with dyspepsia symptoms who underwent the 13C-urea breath test (13C-UBT) and the H. pylori antigen test (HPS) to test for gastric and oral H. pylori infections between May and August 2023 at The Second Affiliated Hospital of Xi'an Jiaotong University. The participants completed questionnaires on sociodemographic characteristics, medical history, dyspepsia symptoms, oral hygiene status, and oral hygiene practices. In addition, the participants underwent oral exams involving the simplified oral hygiene index (OHI-S), the Debris index (DI-S), the simplified calculus index (CI-S), and the decayed, missing, and filled teeth (DMFT) score.</p><p><strong>Results: </strong>Oral H. pylori infection status was not associated with sex, body mass index (BMI), education, oral hygiene habits, place of residence, or income. Considering sex and BMI, being over 60 years of age significantly increased the risk of developing oral H. pylori infection (OR = 5.51, 95% CI: 1.56-19.46, P = .0081), whereas a lack of history of antibiotic use was identified as a protective factor (OR = 0.45, 95% CI: 0.26-0.77, P = .0036). Additionally, DMFT >4 (OR = 2.54, 95% CI: 1.15-5.61, P = .0210), 0.67 < OHI-S ≤ 1.33 (OR = 1.98, 95% CI: 1.09-3.59, P = .0246), and 0.33<DI≤0.67 (OR = 2.00, 95% CI: 1.11-3.62, P = .0215) were identified as independent risk factors for oral H. pylori infection.</p><p><strong>Conclusion: </strong>The results of our research indicate a relationship between oral health and oral H. pylori infection, suggesting that poor oral hygiene may be associated with an increased risk of oral H. pylori colonization.</p>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aerosol Dispersion and Efficacy of Protective Strategies During Dental Procedures.","authors":"Mustafa Radif, Andrew Young, Eric Salmon, David M Ojcius, Shika Gupta","doi":"10.1016/j.identj.2025.01.015","DOIUrl":"https://doi.org/10.1016/j.identj.2025.01.015","url":null,"abstract":"<p><strong>Introduction and aims: </strong>Aerosol generation during dental procedures poses significant risks due to the potential for transmitting aerosol-bound microorganisms, including those in dental unit waterlines. This study aimed to quantify aerosol dispersion at various distances from dental procedures using a high-speed electric handpiece, with a focus on the effectiveness of various aerosol mitigation strategies.</p><p><strong>Methods: </strong>Employing a mannequin head with an artificial tooth (typodont), we simulated clinical settings without the use of saliva to solely assess the contribution of dental unit waterlines and mechanical factors to aerosol production. Measurements were taken using a spectrometer at distances of 0, 0.9, and 1.8 meters from the handpiece.</p><p><strong>Results: </strong>The results showed no significant difference in aerosol dispersion between 0.9 and 1.8 meters without evacuation. In contrast, the use of high-volume evacuators, particularly the Isolite system, significantly decreased aerosol dispersion across all distances.</p><p><strong>Conclusion: </strong>We found that any type of high-volume evacuator can decrease aerosol dispersion, but the use of Isolate was the most effective.</p><p><strong>Clinical relevance: </strong>The results from this study can influence choice of safety measures to minimize aerosol spread during dental procedures.</p>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical Evaluation of Cantilevered 2-Unit Implant-Supported Prostheses: A 3D Finite Element Study.","authors":"Hatem S Sadek, Noha M Anany, Al-Hassan Diab, Mohamed I El-Anwar, Abdulaziz Alhotan, Mostafa Aldesoki, Christoph Bourauel, Tarek M Elshazly","doi":"10.1016/j.identj.2025.01.014","DOIUrl":"https://doi.org/10.1016/j.identj.2025.01.014","url":null,"abstract":"<p><strong>Objective: </strong>To assess the biomechanical performance of cantilevered 2-unit implant-supported prostheses with zirconia and polyetherketoneketone (PEKK) under 3 loading conditions.</p><p><strong>Method: </strong>A cone beam computer tomography (CBCT) scan of an edentulous mandible was segmented using Mimics software and refined in 3-Matic software to create trabecular and cortical bone structures. Implant CAD files were integrated using SolidWorks software, generating 4 models with varying implant positions: M1 (first premolar implant supporting a second premolar), M2 (second premolar implant supporting a first premolar), M3 (second premolar implant supporting a first molar), and M4 (first molar implant supporting a second premolar). Prostheses were constructed from zirconia or PEKK. Finite element analysis (FEA) in ANSYS software simulated static loading: vertical (100 N) and oblique (30° and 45°, 50 N). von Mises stress and total deformation were analyzed.</p><p><strong>Results: </strong>Vertical loading showed the highest von Mises stress at cantilever connectors, with M3 displaying the highest cortical bone stress (117 MPa). Zirconia models had slightly higher prosthetic stress, while PEKK models exhibited greater implant and cortical bone stress. Oblique loading caused higher stress in implants and prostheses but remained below yield limits. Maximum deformation was under 25 micrometers for the implant and bone, and 65 micrometers for the prosthesis.</p><p><strong>Conclusion: </strong>Single implants can support 2-unit cantilevered prostheses when additional implants are unfeasible. The location of the cantilever has minimal impact compared to its size, as a larger cantilevered part increases stress. Zirconia better resists bending forces and reduces implant stress compared to PEKK.</p><p><strong>Clinical significance: </strong>This study guides prosthodontists in designing 2-unit implant-supported prostheses, emphasizing that multiple implants optimize stress distribution, and that zirconia is preferable for cantilevered designs.</p>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Between miR-27a-3p Polymorphisms and Peri-Implantitis Susceptibility: A Case-Control Study.","authors":"Xiaojie Gao, Yanan Ha","doi":"10.1016/j.identj.2025.01.013","DOIUrl":"https://doi.org/10.1016/j.identj.2025.01.013","url":null,"abstract":"<p><strong>Background: </strong>Peri-implantitis (PI) is characterised by a chronic inflammatory response that affects both the soft and bone tissues around dental implants. Inflammatory condition, coupled with alterations in bone metabolism, may be modulated by miR-27a-3p.</p><p><strong>Aim: </strong>This research aims to investigate the relationship between miR-27a-3p rs895819 polymorphism with PI susceptibility, along with its effects and mechanism on inflammatory factors.</p><p><strong>Methods: </strong>Relative miR-27a-3p level was assessed using reverse transcription-polymerase chain reaction (RT-PCR). rs895819 was genotyped by restriction fragment length polymorphism. Enzyme-linked immunosorbent assay (ELISA) kits detected the concentrations of RUNX1, C-reactive protein (CRP), and interleukin-6 (IL-6). Overlapping target genes of miR-27a-3p were identified from databases, including ENCORI, miRDB, and TargetScan databases, which facilitated the selection of target genes of miR-27a-3p. Overlap genes were compiled by the Venn diagram. Functional enrichment analysis for target genes was performed via Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Protein-Protein Interaction (PPI) networks.</p><p><strong>Results: </strong>Underexpressed miR-27a-3p was discovered in PI patients. GG genotype (crude: odds ratio (OR) = 2.898, 95% confidence interval (CI) = 1.419-5.917; adjusted: OR = 2.157, 95% CI = 1.045-4.455) and G allele (P = .003, OR = 1.501, 95% CI = 1.144-1.968) of rs895819 demonstrates a significant association with an enhanced PI susceptibility. The direct target gene RUNX1 has been identified from these databases. PI patients possessing rs895819 GG genotype exhibit diminished level of miR-27a-3p and elevated concentrations of RUNX1 (P < .05), CRP (P < .001), IL-6 (P < .001), and white blood cell (WBC) count (P < .05).</p><p><strong>Conclusion: </strong>These results suggest that rs895819 of miR-27a-3p serves as a significant risk predictor for PI patients. This variant is associated with decreased miR-27a-3p levels, alongside elevated RUNX1 levels and inflammatory factor levels in PI patients.</p>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Cancer Knowledge and Screening Practices Among Dental Professionals in Yemen: a Web-Based Survey.","authors":"Sadeq Ali Al-Maweri, Esam Halboub, Anas Shamala, Abdulrazzaq Ahmed Al-Maweri, Alaa Daud, Ebrahim Almurisi, Asma Saleh Almeslet, Saba Kassim, Mohammed Nasser Alhajj","doi":"10.1016/j.identj.2024.12.034","DOIUrl":"https://doi.org/10.1016/j.identj.2024.12.034","url":null,"abstract":"<p><strong>Background: </strong>Good knowledge and screening practices of dental professionals for oral cancer (OC) will inevitably improve its prognosis. The present study sought to evaluate OC knowledge and practices among dental professionals in Yemen.</p><p><strong>Methods: </strong>This study was conducted among Yemeni dentists. The used tool was a prevalidated online questionnaire composed of items on the knowledge, practices, and barriers of OC screening and early detection. The data were managed and analysed using SPSS Version 28.0.</p><p><strong>Results: </strong>A total of 506 dental professionals completed the questionnaire. The participants showed moderate levels of knowledge on risk factors and clinical signs of OC. While the majority reported tobacco (89.9%) as a potential risk factor, only 76.7% and 57.5% of the subjects reported a potential role for alcohol consumption and old age. Regarding clinical signs, the majority reported that OC can present as nonhealing ulcer (90.3%) or white/red patch (87.2%), yet only 73.7% reported that it can present as swelling/lump, and around 32% reported that teeth attrition is one of its clinical signs. Concerning practices, most of the participants reported asking their patients about their tobacco habits (84%), routinely examine patients' oral mucosa (81.4%), and refer suspicious lesions to specialists (91.3%). Only 44.9% reported feeling confident regarding their knowledge and training on OC. Specialists and those who attended educational courses on OC were more knowledgeable, more confident, and showed better practices than their counterparts. Inadequate knowledge/training, lack of time, and lack of financial compensation were the most reported barriers to OC screening and early detection.</p><p><strong>Conclusion: </strong>The present study indicates marked gaps in the knowledge and screening practices of OC among Yemeni dentists. Therefore, conducting periodic continuing courses along with interventional trainings are urgently recommended to address these gaps.</p>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sector-differences in Adults' Dental Care Service Utilisation: 11-year Register-based Observations.","authors":"Miira M Vehkalahti, Ulla Palotie, Sinikka Varsio, Kaija Hiltunen","doi":"10.1016/j.identj.2024.12.035","DOIUrl":"https://doi.org/10.1016/j.identj.2024.12.035","url":null,"abstract":"<p><strong>Objective: </strong>This register-based study evaluated sector-specific differences in adults' utilisation of dental care services in Helsinki, Finland in 2007-2017.</p><p><strong>Methods: </strong>The target population comprised all inhabitants aged 20+ years in Helsinki over an 11-year period, from 2007 to 2017. The data, aggregated into 5-year age groups by treatment year and type of treatment, included inhabitants with at least 1 visit to a dentist in the private or public sector. In 2007-2017, the numbers of all patients ranged between 229,772 and 261,488. The patient age groups were analysed for periodontal, restorative, endodontic, and oral surgery treatment received. Attendance rates (%) refer to the number of patients per number of inhabitants. Proportions (%) of patients receiving various treatment types refer to numbers of patients per all patients. Comparisons between the age groups included percentual change in absolute numbers and percentage points in rates. The treatment-year trends were analysed by applying linear regression models.</p><p><strong>Results: </strong>Attendance rate for all adult patients was 49.5% in 2007 and 48.8% in 2017. During the 11-year period, adults' attendance to private service decreased (31.4%-24.9%) but increased to public service (18.1%-23.9%). Patients receiving periodontal care increased in both the private (67%-72%) and public (36%-45%) sectors, while patients with restorative care decreased in both sectors private (67%-58%) and public (58%-48%). Further, fewer private- than public-sector patients received oral surgery or endodontic treatment.</p><p><strong>Conclusions: </strong>Sector-specific differences in patient treatments may indicate over- or undertreatment choices in restorative and periodontal care.</p>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Occlusion Asymmetry and Temporomandibular Disorders: A Cross-Sectional Study.","authors":"Donghui Guo, Jie Gao, Wen Qin, Xian Wang, Shaoxiong Guo, Zuolin Jin, Meiqing Wang","doi":"10.1016/j.identj.2025.01.003","DOIUrl":"https://doi.org/10.1016/j.identj.2025.01.003","url":null,"abstract":"<p><strong>Background: </strong>The association between occlusion and temporomandibular disorders (TMD) remains obscure. The present purpose was to explore the asymmetrical occlusion feature(s) potentially linked to TMDs.</p><p><strong>Methods: </strong>This study enrolled 148 patients with a chief complaint of malocclusion. Of those, 84 had no signs of TMD (Group-ORD1), and 64 had signs of TMD (Group-ORD2). An additional 84 patients with a chief complaint of TMD symptoms and a history of orthodontic therapy were included (Group-TMD). All patients in the study were female. Asymmetry of six occlusion variables was measured on plaster study casts and recorded as 1 for asymmetry and 0 for symmetry. The variables contain the sagittal asymmetry: the first molar mesial-distal relationship (F1), canine mesial-distal relationship (F2); the horizontal asymmetry: anterior overjet and overbite relationship (F3), posterior overjet and overbite relationship (F4); missing teeth (F5), and the weight of the asymmetrical occluding pair (F6). And logistic regression model was used for data analyses.</p><p><strong>Results: </strong>In the analyses for Group-ORD2 versus Group-ORD1, the F6 variable and the interactions of F1*F2 and F1*F2*F6 were entered into the model (all OR > 2.68). For Group-TMD versus Group-ORD1, the variables were F1, F5, and F6 (all OR > 2.39) and F4 (OR = 0.28), and the interactions were F5*F6, F1*F2*F6, F1*F5*F6, and F1*F2*F5*F6 (all OR > 2.78) and F2*F4, F3*F5, and F2*F4*F6 (all OR < 0.13). For Group-TMD versus Group-ORD2 the variables and interactions were F5, F5*F6, and F1*F5*F6 (all OR > 4.03) and F4, F4*F6 and F2*F4*F6 (all OR < 0.21) (all P < .05).</p><p><strong>Conclusions: </strong>Patients with sagittal asymmetry, asymmetrical missing teeth, or asymmetrical weight of contact have a higher prevalence of TMD.</p>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Effect of Different Preoperative Antibiotics on Dental Implant Failure: A Retrospective Cohort Study.","authors":"Georgios S Chatzopoulos, Larry F Wolff","doi":"10.1016/j.identj.2025.01.012","DOIUrl":"https://doi.org/10.1016/j.identj.2025.01.012","url":null,"abstract":"<p><strong>Background: </strong>There is a lack of standardized guidelines for the prescription of antibiotics prior to implant surgery. The purpose of this study was to compare the effect of different antibiotics preoperatively on dental implant treatment outcome.</p><p><strong>Methods: </strong>This retrospective analysis involved a cohort of patients who received dental implant treatment at ten university dental clinics participating in the BigMouth network. All patients records who received antibiotic medication prior to implant surgery including amoxicillin, amoxicillin/clavulanic acid, clindamycin, azithromycin, ciprofloxacin, doxycycline, and metronidazole were analysed. The treatment outcome was assessed as a binary outcome, classified as either survival or failure of the implant.</p><p><strong>Results: </strong>A total of 41,135 implants inserted in 17,483 individuals and followed-up for a mean time of 81 ± 52.33 months. The implant failure rate was 3% at the patient level and 1.6% at the implant level. Hispanic and non-Hispanic ethnic groups showed higher likelihood to have an implant failure than other races, as well as White and African-American races, were more likely to experience implant loss compared to Hispanic patients. Implants placed in patients who received Ciprofloxacin preoperatively showed significantly lower cumulative survival implant time than those who had amoxicillin.</p><p><strong>Conclusions: </strong>Within the limitations of this retrospective study, premedication with Ciprofloxacin led to statistically significant lower implant survival time than with amoxicillin. Future prospective randomized clinical trials are needed to validate the present findings.</p>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soft Tissue Augmentation by Electrospun Membranes embedded With Nano-Hydroxyapatite: Histologic and Volumetric Analyses.","authors":"Yu Zhu, Zuohui Xiao, Yingxin Gu, Qiang Zhi, Zhuoli Huang, Yijie Zhang, Chunan Zhang, Shichong Qiao","doi":"10.1016/j.identj.2025.01.005","DOIUrl":"https://doi.org/10.1016/j.identj.2025.01.005","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to assess the histologic and volumetric alteration in gingival tissues following grafting with electrospinning collagen membranes blended with nanophased hydroxyapatite (nHA) on the buccal side of canine teeth.</p><p><strong>Methods: </strong>Four adult beagle dogs underwent hemisecting of the mandibular premolars, followed by the extraction of the mesial roots. Soft tissue augmentations were randomly conducted with collagen membranes composed of poly (L-Lactic-co-caprolactone) and porcine fibrinogen (PLCL/F-Fg), PLCL/F-Fg membranes blended with nHA (PLCL/F-Fg/nHA), or a sham-operated control. The animals were sacrificed at 12 weeks post-surgery and received volumetric analyses. Histological examinations at the meantime were carried out at five different depths below the crest (0, 1.5, 2.5, 3.5 and 5.5 mm).</p><p><strong>Results: </strong>Histological examinations showed a statistically significant increase in buccal gingival thickness between PLCL/F-Fg/20%nHA and PLCL/F-Fg (3.82 ± 1.56mm vs 1.78 ± 0.20mm (at 3.5 mm); 4.23 ± 0.63mm vs 1.80 ± 0.58mm (at 5.5 mm)) as well as between PLCL/F-Fg/20%nHA and PLCL/F-Fg/10%nHA (4.23 ± 0.63mm vs 1.97 ± 0.73mm (at 5.5 mm)). Volumetric analyses showed a statistically significant decrease in volume reduction between PLCL/F-Fg/20%nHA and PLCL/F-Fg (4.46 ± 2.75mm³ vs 10.27 ± 4.77mm³) as well as between PLCL/F-Fg/20%nHA and PLCL/F-Fg/10%nHA (4.46 ± 2.75mm³ vs 10.57 ± 2.88mm³).</p><p><strong>Conclusion: </strong>PLCL/F-Fg/20%nHA membranes demonstrated effectiveness in the gingival thickness augmentation on the buccal side of canine teeth at 12 weeks postsurgery. The electrospinning collagen membranes blended with nHA rendered an alternative treatment for soft tissue volume augmentations at the pontic site.</p>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}