International dental journal最新文献

{"title":"Ornidazole Regulates Inflammatory Response and Odontogenic Differentiation of Human Dental Pulp Cells","authors":"Jing Yang ,&nbsp;Zikai Li ,&nbsp;Chengcheng Zhang ,&nbsp;Jiaying Xiong ,&nbsp;Xirui Yang ,&nbsp;Dandan Zheng ,&nbsp;Siming Xie ,&nbsp;Haishan Shi","doi":"10.1016/j.identj.2025.02.008","DOIUrl":"10.1016/j.identj.2025.02.008","url":null,"abstract":"<div><h3>Aim</h3><div>This study aimed to explore the potential of ornidazole as an alternative treatment for pulpitis, focusing on its effects on human dental pulp cells (hDPCs) and macrophages. We assessed the cytotoxicity of various concentrations of ornidazole, its safety and efficacy in treating inflamed hDPCs, and its regulatory impact on inflammatory markers during inflammation.</div></div><div><h3>Materials and Methods</h3><div>Inflammation in hDPCs was induced using lipopolysaccharides (LPS), and varying doses of ornidazole were introduced. Cell proliferation, migration, inflammation regulation, and dentinogenesis under inflammatory conditions were evaluated. Additionally, macrophages were cultured with different doses of ornidazole to analyse the expression of inflammatory genes. If statistically significant differences were observed between the control and treatment groups, this was considered evidence of ornidazole's effects on hDPCs. Statistical analysis was performed using SPSS 26.0, with one-way analysis of variance and Tukey's test for comparisons. A <em>P-</em>value of &lt; 0.05 was considered statistically significant.</div></div><div><h3>Results</h3><div>Ornidazole influenced cell proliferation, inflammation regulation, and dentinogenesis. Concentrations below 10 µg/mL did not exhibit significant cytotoxic effects on hDPCs over a 7-day period, and the cytotoxicity of ornidazole was both concentration- and time-dependent. Ornidazole decreased the expression of proinflammatory markers (IL-6 and TNF-α) while enhancing the expression of anti-inflammatory markers (IL-1Ra and IL-8). It also suppressed alkaline phosphatase (ALP) activity but increased the expression of odontogenic differentiation markers at both mRNA and protein levels in the presence of inflammatory stimuli. Furthermore, ornidazole demonstrated immunomodulatory effects on macrophages.</div></div><div><h3>Conclusions</h3><div>Low concentrations of ornidazole were found to be safe for hDPCs. Ornidazole modulated the expression of inflammatory markers (IL-6, TNF-α, IL-8, IL-1Ra) in inflamed hDPCs and regulated odontogenesis-related markers. Furthermore, low concentrations of ornidazole enhanced the immune regulation in macrophages, highlighting its potential as a therapeutic agent for pulpitis.</div></div><div><h3>Clinical Relevance</h3><div>This study aimed to understand the interactions of ornidazole with hDPCs, its anti-inflammatory properties, and its regulatory effects on odontogenic processes. By examining the impact of different concentrations of ornidazole on cells associated with pulp inflammation, this study provides valuable insights into its therapeutic potential for pulpitis and tends to support its clinical application.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 3","pages":"Pages 1522-1531"},"PeriodicalIF":3.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143680251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reassessing the Performance of Large Language Models in Oral Health Questionnaires: Interpretative Considerations","authors":"Carlos M. Ardila,&nbsp;Pradeep Kumar Yadalam","doi":"10.1016/j.identj.2025.02.027","DOIUrl":"10.1016/j.identj.2025.02.027","url":null,"abstract":"","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 3","pages":"Pages 1564-1565"},"PeriodicalIF":3.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143680333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large Language Models Do Not Resolve Controversies Regarding Infective Endocarditis Prophylaxis","authors":"Pedro Diz Dios,&nbsp;Hoda Tayebi Hillali,&nbsp;Marcio Diniz Freitas,&nbsp;Javier Fernández Feijoo","doi":"10.1016/j.identj.2025.03.001","DOIUrl":"10.1016/j.identj.2025.03.001","url":null,"abstract":"","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 3","pages":"Pages 1508-1509"},"PeriodicalIF":3.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143680332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Helicobacter Pylori Infection and Periodontal and Gastric Diseases: A Meta-Analysis","authors":"Qinghua Liu ,&nbsp;Ying Zhang ,&nbsp;Fengxiang Qi","doi":"10.1016/j.identj.2024.12.027","DOIUrl":"10.1016/j.identj.2024.12.027","url":null,"abstract":"<div><h3>Background</h3><div><em>Helicobacter pylori</em> (Hp) infection has been implicated in both gastric and extra-gastric diseases, including periodontitis.</div></div><div><h3>Methods</h3><div>This meta-analysis investigated the association between <em>Helicobacter pylori</em> (Hp) infection and periodontitis by systematically reviewing eight studies. The analysis was conducted using the R package “meta,” employing both fixed effects and random effects models. The level of heterogeneity among the studies was assessed using the I-squared statistic and tau values. Publication bias was evaluated through funnel plots, Begg's rank correlation, and Egger's regression tests to ensure the robustness of the findings.</div></div><div><h3>Results</h3><div>The meta-analysis included a total of 6061 observations, with 1404 cases of periodontitis. The fixed effects model produced an odds ratio (OR) of 2.3392 (95% confidence interval [CI]: 2.0207-2.7078), and the random effects model yielded a similar OR of 2.3220 (95% CI: 2.0050-2.6892). The I-squared statistic indicated low to moderate heterogeneity among the studies. Subgroup analyses demonstrated consistent associations across different Hp diagnostic methods.</div></div><div><h3>Conclusion</h3><div>Hp infection is significantly associated with an increased risk of periodontitis, highlighting its role in both gastric and oral health.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 3","pages":"Pages 1510-1521"},"PeriodicalIF":3.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143680249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patent Analysis of Dental CBCT Machines","authors":"Andy Wai Kan Yeung ,&nbsp;Andrew Nalley ,&nbsp;Kuo Feng Hung ,&nbsp;Anne Caroline Oenning ,&nbsp;Ray Tanaka","doi":"10.1016/j.identj.2025.02.023","DOIUrl":"10.1016/j.identj.2025.02.023","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>Cone Beam Computed Tomography (CBCT) has become a crucial imaging tool in modern dentistry. At present, a review does not exist to provide comprehensive understanding of the technological advancements and the entities driving the innovations of CBCT. This study aimed to analyse the patent records associated with CBCT technology, to gain valuable insights into the trends and breakthroughs, and identify key areas of focus from manufacturers.</div></div><div><h3>Methods</h3><div>The online patent database called The Lens was accessed on 3 January 2025 to identify relevant patent records.</div></div><div><h3>Results</h3><div>A total of 706 patent records were identified and analysed. The majority of over 700 CBCT patents was contributed by CBCT manufacturers. The United States was the jurisdiction with most patent records, followed by Europe and China. Some manufacturers hold patent records for common features of CBCT systems, such as motion artifact correction, metal artifact reduction, reconstruction of panoramic image based on 3D data, and incorporation of artificial intelligence.</div></div><div><h3>Conclusion</h3><div>Patent analysis can offer valuable insights into the development and advancement of CBCT technology, and foster collaboration between manufacturers, researchers, and clinicians.</div></div><div><h3>Clinical Relevance</h3><div>The advancements in CBCT technology, as reflected by patent trends, enhance diagnostic accuracy and treatment planning. Understanding these technological innovations can aid clinicians in selecting the most effective imaging tools for patient care.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 3","pages":"Pages 1493-1498"},"PeriodicalIF":3.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143680335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Intensity Focused Ultrasound Versus Airflow® in Debriding Ti-Attached S. mutans Biofilms","authors":"Minh Dien Tran,&nbsp;Sheetal Maria Rajan,&nbsp;Hien Ngo,&nbsp;Amr Fawzy","doi":"10.1016/j.identj.2024.12.037","DOIUrl":"10.1016/j.identj.2024.12.037","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>Effective management of biofilm-associated peri-implantitis requires the eradication of microbial biofilms to control disease progression and preserve implant osseointegration. However, achieving complete biofilm removal remains a challenge. High-intensity focused ultrasound (HIFU) is an emerging technology offering non-ionizing radiation, no extraneous materials, and minimal residuals or aerosols. This in vitro study compared the effectiveness of HIFU and a commercial air-pressured abrasive method (Airflow®) in removing <em>Streptococcus mutans</em> biofilms attached to Titanium (Ti) discs.</div></div><div><h3>Methods</h3><div>Bacterial biofilms were grown on 36 pairs of machined (M) and roughened (R) Ti discs for 10 days. Biofilms in the test group (12 pairs) were treated with the optimized HIFU for 2 min in a water medium and the residual biofilms were examined using two imaging methods, confocal laser scanning microscopy (CLSM), scanning electron microscopy (SEM), and three quantitative methods including crystal violet (CV), 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) and flow cytometry (FCM) assays for biomass, bacterial viability, and live/dead bacterial counts respectively. The data from the test and the control samples (untreated and Airflow® treated) were subjected to ANOVA followed by post-hoc Tukey's test to determine the statistical differences between the groups.</div></div><div><h3>Results</h3><div>Except the MTT data from M discs, the findings showed that both HIFU and Airflow® methods achieved similar levels of bacterial debridement, removing over 99% of bacteria in FCM assays (99.8 ± 0.16% versus 99.3 ± 0.49% for M discs, 99.96 ± 0.02% versus 99.5 ± 0.37% in for R discs). Complete biofilm removal was noted in HIFU-treated samples compared to the Airflow® in SEM images.</div></div><div><h3>Conclusion and clinical relevance</h3><div>Our findings indicate that both novel HIFU and traditional Airflow® methods were equally effective in removing the <em>S. mutans</em> biofilms from titanium disc surfaces. Further research is needed to explore the clinical application of HIFU in managing peri-implantitis.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 3","pages":"Pages 1532-1543"},"PeriodicalIF":3.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143680261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Cross-Sectional Study of Quadratic-Linear Correlations Between Cephalometric Measurements and Profile Esthetics in Adult Orthodontic Patients","authors":"Visessan Pornsirianand ,&nbsp;Janeta Chavanavesh ,&nbsp;Pimsiri Kanpittaya ,&nbsp;Anupap Somboonsavatdee","doi":"10.1016/j.identj.2025.02.015","DOIUrl":"10.1016/j.identj.2025.02.015","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>Modern orthodontics prioritises the soft tissue paradigm as the main treatment goal. This study used quadratic and/or linear regression to identify cephalometric variables related to profile attractiveness, expanding on previous bivariate analyses.</div></div><div><h3>Methods</h3><div>This retrospective cross-sectional study comprised 180 post-treatment lateral cephalograms of 18 to 37 year-old orthodontic patients, equally distributed among 3 profile types (concave, straight, and convex), each comprising 60 cases with balanced sex representation. Profile silhouette attractiveness score (dependent variable) was rated by 30 orthodontists and 30 laypeople using a 5-point Likert scale. Cephalometric parameters (105 independent variables) were analyzed using Dolphin and ImageJ software. Factor analysis identified closely related variables, and 41 selected cephalometric variables were used in correlation and multiple regression analyses to explore their relationships with attractiveness scores separately for orthodontists and laypeople using the R programming language.</div></div><div><h3>Results</h3><div>Quadratic correlations were stronger than linear in both groups' perspectives. For laypeople, throat length (linear), facial contour angle, interlip angle, mentolabial angle, and lip-chin-throat angle (quadratic) significantly correlated with attractiveness scores. For orthodontists, nasolabial angle and throat length (linear), upper lip position to facial plane, mentolabial angle, and lip-chin-throat angle (quadratic) significantly correlated with attractiveness scores. Combined quadratic-linear regression models yielded adjusted R² = 0.5628 for laypeople and adjusted R² = 0.5241 for orthodontists.</div></div><div><h3>Conclusion</h3><div>Soft tissue cephalometric variables, including throat length, mentolabial angle, and lip-chin-throat angle, should be the key treatment goals for esthetic facial profiles. Facial contour and interlip angles are also important to laypeople.</div></div><div><h3>Clinical Relevance</h3><div>Orthodontists should focus on modifying the soft tissue cephalometric variables of the lower face area to improve the patient esthetics.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 3","pages":"Pages 1472-1481"},"PeriodicalIF":3.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143680263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KLF2 Promotes Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Regulating Nrf2 Expression","authors":"Jiujiu Chen ,&nbsp;Lichao Deng","doi":"10.1016/j.identj.2025.02.019","DOIUrl":"10.1016/j.identj.2025.02.019","url":null,"abstract":"<div><h3>Objective</h3><div>Periodontal ligament stem cells (PDLSCs) are emerging as a promising source for periodontal regeneration and to manage periodontitis. This study aims to investigate the roles of Krüppel-like factor 2 (KLF2) and nuclear factor erythroid 2-related factor (Nrf2) in mediating osteogenic differentiation of human PDLSCs (hPDLSCs) in the context of lipopolysaccharide (LPS) stimulation.</div></div><div><h3>Methods</h3><div>The osteogenic differentiation potential of hPDLSCs isolated from human premolar root samples were examined by alkaline phosphatase (ALP) staining and ALP activity assay, Alizarin red S staining and quantitative analysis of mineralised matrix. Intracellular reactive oxygen species (ROS) production and glutathione (GSH) concentration were assessed to reflect oxidative stress.</div></div><div><h3>Results</h3><div>KLF2 overexpression influenced Nrf2-regulated transcription, leading to significant increases in GSH concentration, ALP activity, mineralised matrix formation, and RUNX2 expression in LPS-stimulated hPDLSCs, as well as significant reductions in ROS production and cell apoptosis. The subsequent Nrf2 knockdown impaired the protective effect of KLF2 on hPDLSCs against LPS stimulation.</div></div><div><h3>Conclusion</h3><div>The findings of the study demonstrate KLF2 overexpression has the ability to promote the osteogenic differentiation of hPDLSCs by promoting Nrf2 activation, suggesting that KLF2 mediating Nrf2 could be a promising target to facilitate the efficacy of PDLSC-based bone regeneration in periodontitis.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 3","pages":"Pages 1554-1563"},"PeriodicalIF":3.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143680250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Impact of the COVID-19 Pandemic on Dental Care Delivery in Poland: A Single-Center Retrospective Analysis","authors":"Kacper Łaganowski ,&nbsp;Martyna Ortarzewska ,&nbsp;Agata Czajka-Jakubowska ,&nbsp;Anna Surdacka ,&nbsp;Kacper Nijakowski","doi":"10.1016/j.identj.2025.02.024","DOIUrl":"10.1016/j.identj.2025.02.024","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>The COVID-19 pandemic has significantly impacted healthcare systems, including dentistry. This retrospective analysis aims to evaluate long-term changes in the spectrum of performed dental procedures due to the COVID-19 pandemic based on the example of the university specialized centre in Poznan.</div></div><div><h3>Methods</h3><div>We explored the patient dataset from the University Center of Dentistry and Specialized Medicine (Poznan, Poland) covering the period from 1 January 2017 to 31 December 2023. Services performed during the prepandemic (2017-2019), pandemic (2020), and postpandemic (2021-2023) periods were compared. Selected procedures in restorative dentistry, endodontics, dental surgery, and dental radiology were analyzed in detail, including data for both children and adults.</div></div><div><h3>Results</h3><div>Our study analyzed a total of 342,112 patient medical records, including 158,882 conservative procedures and 101,556 surgical procedures. During the pandemic, there was a significant reduction in conservative procedures, particularly commercial services. In the postpandemic period, the number of refunded restorations and endodontic treatments for anterior teeth increased significantly, which was not observed for commercial procedures. A notable disruption between surgical and conservative procedures occurred during the first wave of the pandemic. The prepandemic period and the first quarter of the year were more conducive to conservative and endodontic treatments.</div></div><div><h3>Conclusion</h3><div>The COVID-19 pandemic has led to a significant long-term shift from preventive and conservative dentistry into surgical interventions. Although the overall number of services provided has increased, more patients are opting for procedures that do not require out-of-pocket expenses.</div></div><div><h3>Clinical Relevance</h3><div>The pandemic has a lasting impact on the clinical decisions made by dental patients, with a greater preference for reimbursed and surgical services.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 3","pages":"Pages 1544-1553"},"PeriodicalIF":3.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143680266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental Arch Development of Chinese Adolescents: A Retrospective Cross-Sectional Study","authors":"Chao Liu ,&nbsp;Jieyi Chen ,&nbsp;Mengjuan Cui ,&nbsp;Zhengliang Wang ,&nbsp;Wentao Shi ,&nbsp;Siyuan Du ,&nbsp;Yang Feng ,&nbsp;Manfei Zhang ,&nbsp;Zhenxia Li ,&nbsp;Shufei Ge ,&nbsp;Bing Fang","doi":"10.1016/j.identj.2025.02.026","DOIUrl":"10.1016/j.identj.2025.02.026","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>Understanding the patterns of dental arch development is crucial for precise diagnosis and management of malocclusion in adolescents. However, large-scale, region-specific analyses based on big data are scarce.This study aimed to identify the dental arch growth patterns of Chinese adolescents to refine early orthodontic treatment strategies.</div></div><div><h3>Methods</h3><div>A retrospective cross-sectional analysis was conducted using 3D digital impressions from 5951 Chinese adolescents, collected between July 2020 and June 2021. AI-assisted measurements delineated dental arch dimensions, which were analyzed using locally weighted regression to chart developmental trends and Lasso regression to explore influencing factors, with a particular focus on geographical variances.</div></div><div><h3>Results</h3><div>Significant differences in dental arch dimensions were observed between genders and across different latitudes. Males generally displayed larger arch dimensions than females of the same age. The dental arches experienced rapid growth before age 13.7 in males and 13.1 in females, with limited growth potential in later years, with regional disparities evident in the magnitude of dental arch dimensions. These variations were prominently associated with geographical latitude, underscoring the influence of environmental factors on dental arch development.</div></div><div><h3>Conclusion</h3><div>This comprehensive study provides valuable regional insights into the dental arch development of Chinese adolescents, facilitated by advanced AI methodologies. The fitted curves of age-specific dental arch offer valuable insights for optimizing early orthodontic treatment strategies. The findings advocate for region-tailored orthodontic planning and highlight the potential of AI in enhancing the precision of orthodontic treatment.</div></div><div><h3>Clinical Relevance</h3><div>Our study of 5951 3D dental models reveals gender and geographical differences in arch growth, highlighting pre-teen rapid growth and later limitations, informing treatment planning.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"75 3","pages":"Pages 1482-1492"},"PeriodicalIF":3.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143680793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}