INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH最新文献_第4页

EVALUATION OF ANTI-ULCER ACTIVITY OF METHANOLIC EXTRACT OF LAGENARIA SICERARIA 木槿花甲醇提取物抗溃疡活性评价

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2021-09-27 DOI: 10.31069/japsr.v4i2.4

Vivek Srivastava, Priyanka Gupta, Deepika Sharma

{"title":"EVALUATION OF ANTI-ULCER ACTIVITY OF METHANOLIC EXTRACT OF LAGENARIA SICERARIA","authors":"Vivek Srivastava, Priyanka Gupta, Deepika Sharma","doi":"10.31069/japsr.v4i2.4","DOIUrl":"https://doi.org/10.31069/japsr.v4i2.4","url":null,"abstract":"Introduction: Ulcer is a common gastrointestinal disorder and can be characterized by inflamed lesions of the mucosa and tissue that protect the gastrointestinal tract. These ulcers can develop when the imbalance occurs between the gastroprotective (mucus, bicarbonate, and prostaglandins) and aggressive (acid, pepsin, bile salts, and Helicobacter pylori bacteria). According to research and as other species from genus Lagenaria shows analgesic, anti-inflammatory, immunomodulatory, antihyperlipidemic, diuretic, and antihelmintic activities on the fruit of Lagenaria siceraria. \u0000Methods: The anti-ulcer activity of methanolic extract of Lagenaria siceraria fruits was investigated in pylorus ligation, ethanol-induced, Asprin induced and Cold-restraint stress-induced ulcer models in Wistar rats. In all models, the common parameter determined was the ulcer index. \u0000Results: The extract (100 mg/kg & 200 mg/kg) showed a significant (P<0.005) reduction in gastric volume, free acidity, and ulcer index as compared to control. This present study indicates that Lagenaria siceraria fruit extract has potential anti-ulcer activity in these models. \u0000Discussion: MELS caused a significant decrease in the gastric volume, free acidity, and total acidity compared to the control group, indicating an antisecretory mechanism. Several scientific studies revealed that phytoconstituents like flavonoids, tannins, terpenoids, and saponin were responsible for gastroprotective agents. Further studies are needed to find out their exact mechanism of action on gastric acid secretion and gastric cytoprotection.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89175372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A FIELD SURVEY AFTER COVID-19 IMMUNIZATION PROGRAMME AT GHAZIABAD, INDIA: HIGHLIGHTING ADVERSE EVENTS 印度加济阿巴德COVID-19免疫规划后的实地调查:突出不良事件

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2021-09-27 DOI: 10.31069/japsr.v4i2.3

Sagarika Majhi, Madhu Verma, Iti Chauhan, Raj Kumari, Meenakshi Sharma

{"title":"A FIELD SURVEY AFTER COVID-19 IMMUNIZATION PROGRAMME AT GHAZIABAD, INDIA: HIGHLIGHTING ADVERSE EVENTS","authors":"Sagarika Majhi, Madhu Verma, Iti Chauhan, Raj Kumari, Meenakshi Sharma","doi":"10.31069/japsr.v4i2.3","DOIUrl":"https://doi.org/10.31069/japsr.v4i2.3","url":null,"abstract":"Background: COVID-19 has been named as the third most pathogenic human coronavirus disease till date. The SARS-CoV-2 epidemic is still continued, and the new strain is expected to co-habit with us for a significant duration. The only way of protection from SARS-CoV-2 depends upon public health interventions such as active testing, along with immediate tracking of cases and limited social gatherings until clinically approved vaccines become widely available. Further, personal prophylactic measures such as social interspacing and proper use of quality masks can prevent the spread of this contagious virus. \u0000Objective: The current protocol is aimed to collect data on adverse event, after COVID vaccination and such studies in future can help in prevention and treatment of COVID-19. \u0000Method: The protocol was conducted in selected centres of Uttar Pradesh, India. It was done over a time period of 3 months. A valid protocol includes two shots of immunization procedure for all enrolled participants. Immediate (within 6 hrs), sudden (within 24 hours) and delayed adverse events occurred after 24 hours of vaccine administration were noted. \u0000Conclusion: In India, vaccine pharmacovigilance is still in its developmental stages. Irrespective of whether adverse event (AE) after immunization (AEFI), a steady stream of full information on vaccine-related AE is required. Because there is so few Indian researches on vaccination adverse effects, as a result, need for vaccine pharmacovigilance on a broad scale in India has emerged in recent times.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78192571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF CEFIXIME TRIHYDRATE IN BULK AND DOSAGE FORM BY UV-VISIBLE SPECTROSCOPY 紫外可见光谱法测定三水合头孢克肟原料药和剂型的分析方法

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2021-09-27 DOI: 10.31069/JAPSR.V4I2.2

A. A. Chowdhury, Masuma Akter Brishti, Giyas Uddin, Fazlul Karim Tipu, Shaila Kabir, Md. Shah Amran

{"title":"ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF CEFIXIME TRIHYDRATE IN BULK AND DOSAGE FORM BY UV-VISIBLE SPECTROSCOPY","authors":"A. A. Chowdhury, Masuma Akter Brishti, Giyas Uddin, Fazlul Karim Tipu, Shaila Kabir, Md. Shah Amran","doi":"10.31069/JAPSR.V4I2.2","DOIUrl":"https://doi.org/10.31069/JAPSR.V4I2.2","url":null,"abstract":"Objective: This work aimed to validate a simple UV-Visible spectrophotometric method for estimating Cefixime trihydrate in bulk and to produce an accurate, precise, repeatable, and cost-effective method. \u0000Material and Methods: The pH 7.4 Phosphate buffer was utilized as the solvent throughout the experiment. The drug’s absorption maxima (max) were discovered to be at 288 nm. Beer’s law was found to be obeyed in the range of 10-45 μg/mL during the quantitative analysis of the substance at 288 nm. In the doses tested, the approach was found to be linear, with the line equation y = 0.035x – 0.002 and a correlation coefficient of 0.999. \u0000Results and Discussion: Cefixime Trihydrate recovery values varied from 99.656 percent to 101.825 percent. Six duplicates of the experiment had a relative standard deviation of less than 2%. The interday precision range was 0.52-1.02%, and the intraday precision range was 0.57-0.995 percent relative standard deviation (RSD percent). The detection and quantification limits were 0.914 and 3.142 μg/mL, respectively. The method’s robustness and ruggedness had a percent relative standard deviation of 0.532-0.827 percent. \u0000Conclusion: As a result, the proposed procedure was precise, accurate, and economical. This method could be used to determine the quantity of medicine in bulk.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85567588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

ISODEOXYELEPHANTOPIN (IDOE) RETARDS TUMOR CELL MIGRATION BY DOWNREGULATING MMP-2/9 EXPRESSION IN TRIPLE NEGATIVE BREAST CANCER 异脱氧象皮素通过下调三阴性乳腺癌中mmp-2/9的表达来延缓肿瘤细胞的迁移

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2021-09-27 DOI: 10.31069/japsr.v4i2.5

Suboj Babykutty, A. George, Subinjit J Vijayan, Soya PK Sidheek, Sudheena Sulfath, Athira GG Moly, J. Thomas, Hima Xavier, Prabhakumari Chellama, Dhanya SN Rajalekshmi

{"title":"ISODEOXYELEPHANTOPIN (IDOE) RETARDS TUMOR CELL MIGRATION BY DOWNREGULATING MMP-2/9 EXPRESSION IN TRIPLE NEGATIVE BREAST CANCER","authors":"Suboj Babykutty, A. George, Subinjit J Vijayan, Soya PK Sidheek, Sudheena Sulfath, Athira GG Moly, J. Thomas, Hima Xavier, Prabhakumari Chellama, Dhanya SN Rajalekshmi","doi":"10.31069/japsr.v4i2.5","DOIUrl":"https://doi.org/10.31069/japsr.v4i2.5","url":null,"abstract":"Introduction: Isodeoxyelephantopin (C19H20O6), plant-derived sesquiterpene, extracted from Elephantopus Scaber Linn., have tremendous contributions in inhibiting the proliferation and metastasis of cancer cells. \u0000Materials and Methods: The cell viability assay was shown to be procured half-maximal inhibitory concentration of isodeoxyelephantopin on the MDA-MB-231cell line. Apoptosis was screened by AO/ EB staining and it was confirmed by annexin V staining. The DNA damaging property of IDOE was examined by comet assay. The cell cycle arrest determined using flow cytometry analysis and the growth inhibition due to the modulation of cell cycle regulatory protein p53 were substantiated by RT PCR. Scratch wound migratory assay was done to evaluate the migratory effect of IDOE on the MDA-MB-231 cell line. RT-PCR analysis showed that expression of MMP-2/9 was inhibited by IDOE treatment. \u0000Result: Anti-proliferative and anti-migratory effect of IDOE was determined by cell cycle analysis and annexin v staining. Cells were arrested in the G2/M phase and it is due to the modulation of cell cycle regulatory protein p53. The mRNA level expression studies of matrix metalloproteinases, MMP-2/9 provide supporting data to prove the anti-migratory property.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80630100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

KNOWLEDGE ATTITUDE AND PERCEPTION ABOUT CONTRACEPTIVES IN FEMALES: A QUANTITATIVE INSIGHT 女性对避孕药具的知识、态度和认知:一项定量研究

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2021-07-09 DOI: 10.31069/JAPSR.V4I1.2

Sagarika Majhi, Muskan Sharma, Pooja Tomar, Pallavi Sharma, Lubhan Singh

{"title":"KNOWLEDGE ATTITUDE AND PERCEPTION ABOUT CONTRACEPTIVES IN FEMALES: A QUANTITATIVE INSIGHT","authors":"Sagarika Majhi, Muskan Sharma, Pooja Tomar, Pallavi Sharma, Lubhan Singh","doi":"10.31069/JAPSR.V4I1.2","DOIUrl":"https://doi.org/10.31069/JAPSR.V4I1.2","url":null,"abstract":"Introduction: In India, the risk of unintended pregnancies and unsafe abortions remains high due to relatively low contraceptive use. There is deficiency of data on knowledge, attitudes, perceptions and practices towards modern contraceptives, sexual and reproductive health especially among the young female students. \u0000Methods and Materials: A survey was conducted onfemales of Meerut region, Uttar Pradesh during February 2019-May 2019. Questionnaire was prepared including knowledge, attitude and perception-based questions and data was collected from females who provided data on socio-demographic characteristics, knowledge, perceptions, attitudes and use of contraceptives, as well as other sexual and reproductive health practices. \u0000Results and Discussion: A total of 83 females responded to the survey; median (IQR) age was 20-25 years, 51.8% in firstyear of study, and nearly three quarters (79.5%) were of Hindu’s faith. Knowledge of any contraceptives was almost universal (99.6 %) but only 22.8 % knew about tubal ligation. In terms of natural methods of contraception known, only (43.3%) were aware about the withdrawal and calendar method of contraception while (33.7%) has knowledge of Lactational amenorrhea method. 68.6%reported lack of knowledge for not using contraception.Overall, 20.4 % reported current contraceptive use, with male condoms being the commonest methods. Overall, 61.4% reported pressure by partner was the reason for the unwanted pregnancy18% ever being pregnant. About 9.63 % of ever pregnant respondents reported ever trying to terminate the pregnancy.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88262193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AN INVESTIGATION ON THE DETECTION OF HUMAN LEUCOCYTE ANTIGEN HLA CLASS I LOCI (A, B, C) AND CLASS II LOCI (DR, DQ) ALLELE FREQUENCY IN NEPALESE POPULATION BY NEXT GENERATION SEQUENCING 尼泊尔人白细胞抗原hla I类位点(a、b、c)和ii类位点(dr、dq)等位基因频率的次世代测序研究

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2021-07-09 DOI: 10.31069/japsr.v4i1.1

Smita Shrestha, Dr. Manish Maurya, D. K. D. Manandhar

{"title":"AN INVESTIGATION ON THE DETECTION OF HUMAN LEUCOCYTE ANTIGEN HLA CLASS I LOCI (A, B, C) AND CLASS II LOCI (DR, DQ) ALLELE FREQUENCY IN NEPALESE POPULATION BY NEXT GENERATION SEQUENCING","authors":"Smita Shrestha, Dr. Manish Maurya, D. K. D. Manandhar","doi":"10.31069/japsr.v4i1.1","DOIUrl":"https://doi.org/10.31069/japsr.v4i1.1","url":null,"abstract":"Introduction:Human Leucocyte antigen (HLA) has offered tremendous contribution to the human population by providing definite and undeniable facts of immense magnitude in relation to human genetics, in disease dynamics and also in transfusion and transplantation. \u0000Materials and Methods: Blood samples of 90 unrelated healthy population residing in kathmandu, a central region of Nepal werecollected .DNA was extracted from the blood samples and the allele frequency for HLA class I loci(HLA –A,-B,-C,) and II loci (DRB1 and DRQ1) was studied byion torrent Next Generation Sequencing platform using GenDxNGSgoRworkflow.Further,the comparison between the most frequently detected HLA alleles in Nepalese population with population of neighboring countries were also done. \u0000Results: A total of 10 HLA *A alleles, 18 HLA*B allels,11 HLA*C alleles,11 HLA*DRB1 and 4 HLA*DQB1 were detected. The most common alleles detected were HLA A*01(16.67%), A *33(31.67%),HLA B*35(13.33%) B*44(11.67%) HLA C* 04(16.67%),C*07(23.33%),C*15(16.67%).HLA - DR*07(16.67%) ,DR*15(25.0%) HLA-DQ *05(38.33%) respectively. Comparison with population of the neighboring countries and Caucasian population revealed that these common alleles were also present in high frequency in North Indian Hindus and in some frequencies with Mongolian and Caucasian population but not with the Chinese population. \u0000Discussion: We believe that this data is the first report of HLA class I loci(HLA A,B,C) and II loci (DR*B1 and DQ*B1) in healthy population from Nepal and this will provide useful information withdiverse applications in Nepal.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73759922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SYNTHESIS AND CHARACTERIZATION OF 4- AMINO-3, 5- DIBROMO- TOLUENE FROM P-TOLUIDINE 对甲苯胺合成4-氨基- 3,5 -二溴-甲苯及表征

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2021-07-09 DOI: 10.31069/JAPSR.V4I1.3

M. Kaur, C. Saini, Amandeep Kaur

{"title":"SYNTHESIS AND CHARACTERIZATION OF 4- AMINO-3, 5- DIBROMO- TOLUENE FROM P-TOLUIDINE","authors":"M. Kaur, C. Saini, Amandeep Kaur","doi":"10.31069/JAPSR.V4I1.3","DOIUrl":"https://doi.org/10.31069/JAPSR.V4I1.3","url":null,"abstract":"Introduction: O-toluidine is an organic compound with the chemical formula CH3C6H4NH2. It is the most important of the three isomer toluidines. It is a colorless liquid although commercial samples are often yellowish. It is a precursor to the herbicides metolachlor and acetochlor. Toluene, formally known as toluol, is a clear, water-insoluble liquid with the typical smell of paint thinners. Materials and Methods: Chemically it is a mono-substituted benzene derivative that is one in which a single hydrogen atom from the benzene molecule has been replaced by a univalent group, in this case, CH3. Toluene reacts as a normal aromatic hydrocarbon towards electrophilic aromatic substitution. Then the mixture is filtered with the help of the filtration method and the product is further dried in a hot air oven and 4- Amino-3, 5- dibromo-toluene is formed as a brominated product. The organic layer was separated and washed once with brine and dried over sodium sulphate to give 4-bromop-toluidine in 98.7% purity. Results and Discussion: The methyl group makes it around 25 times more reactive than benzene in such reactions. The concentrated product’s melting point was 50-52°C. Conclusion: In the face of demands for sustainable and ecologically friendly organic synthesis, clean organic reaction processes which do not use harmful organic solvents are encouraged and are in great demand today. \u0000 ","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84983333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergetic Potential of Combination Probiotic Complex with Phytopharmaceuticals in Valproic Acid Induced Autism: Prenatal Model 益生菌复合物与植物药联合治疗丙戊酸致自闭症的协同作用潜力:产前模型

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2021-07-01 DOI: 10.21477/ijapsr.6.3.02

K. Sunand, G. K. Mohan, V. Bakshi

{"title":"Synergetic Potential of Combination Probiotic Complex with Phytopharmaceuticals in Valproic Acid Induced Autism: Prenatal Model","authors":"K. Sunand, G. K. Mohan, V. Bakshi","doi":"10.21477/ijapsr.6.3.02","DOIUrl":"https://doi.org/10.21477/ijapsr.6.3.02","url":null,"abstract":"Background: Autism spectrum disorder (ASD) is a developing neuronal disorder with hindered social correspondence and repetitive behaviors. Hereditary and ecological factors have been related to this problem, including the introduction of valproic acid during pregnancy. Dysbiosis is the most common comorbid condition in autism, numerous probiotic strains have been known to forestall social impairments in autism. Method: Prenatal autism model was done on 12th embryonic day of pregnancy in Wistar rats with the valproic acid dose 400 mg/kg, i.p. Those offspring exhibiting autistic symptoms were selected for study and were treated with polyphenols, probiotics and their combination for the study period of postnatal day (PND) 08-50. Results: Prenatal model showed significant autistic and dysbiotic symptoms in the animals. With the probiotic and polyphenols treatment combination it was understood that bio-activation of polyphenols are crucial in the correction of neurochemical abnormality, oxidative stress, behavioral deficits and neuroprotection. Probiotic complex with acetyl-l-carnitine combination was also essential for the growth of gut bacteria, functionality of brain. Through this combination study behavioral and biochemical alterations were recovered. Conclusion: Establishing a good ecosystem in the gut with good probiotics and polyphenols-like compounds is essential, gut targeted brain functionality is a remarkable way to challenge autistic disorder, advice on this combination may be helpful in the right way of accessing the gut-brain-axis and useful in amending of autism.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76896497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Iron Oxide Nanoparticles – Characterization and Antimicrobial Studies 氧化铁纳米颗粒-表征和抗菌研究

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2021-07-01 DOI: 10.21477/ijapsr.6.3.01

Disholin Dennison Priya, T. Rajesh, Rachel Syam Sundar, Chandrasekhar Narendhar

{"title":"Iron Oxide Nanoparticles – Characterization and Antimicrobial Studies","authors":"Disholin Dennison Priya, T. Rajesh, Rachel Syam Sundar, Chandrasekhar Narendhar","doi":"10.21477/ijapsr.6.3.01","DOIUrl":"https://doi.org/10.21477/ijapsr.6.3.01","url":null,"abstract":"Nanotechnology is one of the most promising technologies that give us better outcomes from biological and industrial issues. This work ismainly based on the green synthesis of iron oxide nanoparticles, assisted by the flower extract. The nanoparticles were synthesized and characterized using UV Visible spectroscopy with characteristic absorbance peaks at 300 nm and 310 nm. Prominent Fourier-Transform Infrared Spectroscopy (FTIR) peaks were obtained corresponding to phenols, amide group, aromatic ring, hydroxyl group, and carbonate ions involved in the stabilization of iron oxide nanoparticles formation. Dynamic light scattering analysis of nanoparticles showed the average sizes as 80.7 nm. Scanning electron microscope images revealed that the size of iron nanoparticles in the range of 160-300 nm. The green synthesized iron nanoparticles have promising potential to inhibit the growth of bacteria. Iron oxide nanoparticles inhibit E. coli, B. subtilis, P. aeruginosa was also enumerated as antimicrobial study. The phytochemicals alkaloid, flavonoid, glycoside, terpenoid, and saponin present in theSenna auriculata may be attributed to reducing iron oxidenanoparticles.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82429381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Method Development Technologies for Clopidogrel Bisulphate by Improving Solubility and Bioavailability 方法通过提高溶解度和生物利用度来开发盐酸氯吡格雷的技术

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2021-04-01 DOI: 10.21477/ijapsr.6.2.1

Deevan Paul A., A. Neelima, Chitra Prasanthi, N. Kota

{"title":"Method Development Technologies for Clopidogrel Bisulphate by Improving Solubility and Bioavailability","authors":"Deevan Paul A., A. Neelima, Chitra Prasanthi, N. Kota","doi":"10.21477/ijapsr.6.2.1","DOIUrl":"https://doi.org/10.21477/ijapsr.6.2.1","url":null,"abstract":"Clopidogrel bisulphate (CB) is a crystalline, poorly water-soluble drug of bioavailability less than 50%. The drug is an irreversible inhibitor of the P2Y12 adenosine diphosphate receptor found on the membranes of platelet cells. The present work was performed using different polymers such as Polyvinylpyrrolidone (PVP) K-30 and polyvinyl alcohol with varied surfactants such as Tween 80 in comparison by using superdisintegrants like Sodium Starch Glycolate (SSG) and Microcrystalline Cellulose (MCC). By performing the particle size distribution, the size ranges from 232.6 nm to 995.6 nm and the polydispersity index ranges from 0.11 to 0.96, these ranges indicating the good physical nature of nanoparticles. The drug entrapment efficiency (DEE) of clopidogrel bisulphate nanoparticles was found to be in the range of 30.10% to 94.4%. From the study, it was found that F2 formulation containing PVP K-30 and L-arginine has given the best release in 80mins and the maximum cumulative drug release was 96.8% in comparison with other formulation, and the dissolution studies were performed for the seven formulations of prepared clopidogrel bisulphate granules among which F5 formulation containing crospovidone has given maximum drug release of 91.6% within 80mins. Here we state that the method development technologies improve the solubility and bioavailability studies by producing the nanoparticles.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79826782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0