INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH最新文献_第5页

Challenges and Future Prospects of Nanotechnology for Antiviral Drugs 纳米技术用于抗病毒药物的挑战和未来展望

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2021-04-01 DOI: 10.21477/IJAPSR.6.2.2

Kavita Chahal, Renu Mishra

{"title":"Challenges and Future Prospects of Nanotechnology for Antiviral Drugs","authors":"Kavita Chahal, Renu Mishra","doi":"10.21477/IJAPSR.6.2.2","DOIUrl":"https://doi.org/10.21477/IJAPSR.6.2.2","url":null,"abstract":"The emergence and re-emergence of pathogenic viruses during the last few decades are causing several pandemics. This has become a serious public health concern. The major causes could be resistance, latency, and toxicity of the virus. Also, there are other factors like improper diagnosis and immunosuppression caused by antivirals. Hence, the rapid development of antivirals following a conventional protocol of drug development is challenging. However, there is a ray of hope reflected from some alternative approaches such as gene inhibition by RNA interference (RNAi), regulation of gene expression by aptamers, ribozymes, novel drug delivery systems, in silico resources recent advances in nanomedicines. Nanotechnology-based strategies show pinkiepromise to the therapeutic management (diagnosis, treatment, and prevention) of life-threatening viral infections. The basis for the potential pharmaceutical use of nanoparticles includes their interactions with biological interfaces, their particle size, good electrical conductivity, and the Localized Surface Plasmon Resonance effect. This review discusses the strategies, challenges, drawbacks, and prospects of nanotechnology for making effective and safe antiviral drugs.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79939272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR STABILITY INDICATING HPTLC METHOD FOR ASSAY OF STIRIPENTOL IN BULK AND DOSAGE FORM 分析方法的开发和稳定性验证，表明高效液相色谱法测定散装和剂型的斯立戊醇

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2021-01-25 DOI: 10.31069/japsr.v3i4.5

Santosh Kumar Kashid, A. Tapkir, Pravin Choudhari

{"title":"ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR STABILITY INDICATING HPTLC METHOD FOR ASSAY OF STIRIPENTOL IN BULK AND DOSAGE FORM","authors":"Santosh Kumar Kashid, A. Tapkir, Pravin Choudhari","doi":"10.31069/japsr.v3i4.5","DOIUrl":"https://doi.org/10.31069/japsr.v3i4.5","url":null,"abstract":"Introduction: This work is concerned with the stability-indicating method development and validation of Stiripentol in a bulk drug and formulation by high-performance thin-layer chromatographic method (HPTLC). Materials and Methods:The pre-coated silica gel 60 F254 aluminum plate was selected as the stationary phase, and the solvent system consisted of Ethyl acetate: Dichloromethane: Toluene (2:2:6 v/v) used as developing solvents. Analysis of Stiripentol was carried out at 301 nm with Stiripentol being detected at an R(f) of 0.63. The developed method was validated for linearity, accuracy, precision, limit of detection (LoD), limit of quantitation (LoQ), robustness parameters, and stability are determined by force degradation study. Results and Discussion: The correlation coefficient of Stiripentol was 0.994 observed. The calibration plot was linear between 50–300 ng/band, respectively. The average percentage recovery of Stiripentol was found to be 100.25 %. Intra and inter-day precision measured as %RSD was less than 2%. Hence stability study of Stiripentol, it was found to degrade in acidic condition(8.52% - 0.1N HCL for 30 minutes at room temperature), alkali condition(7.47%- 0.1 N NaOH for 30min at room temperature), Hydrolytic condition(4.73%– dist. Water for 30min at room temperature), thermal condition(7.69%-40°C for 30min ), oxidative condition(7.55% - 3% H2O2 for 30min at room temperature) and photolytic UV condition(7.54% -24hr UV radiation) respectively. Stiripentol was unstable in acidic condition and stable in normal dist. Water hydrolytic condition. Conclusion: The proposed method was found to be very sensitive and accurate for the determination of Stiripentol in bulk and formulation.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91117955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

COGNIZANCE FOR COVID 19 VACCINATION: CHOICE OF RECOMBINANT VIRAL VECTOR OR WHOLE VIRION INACTIVATED VACCINE covid - 19疫苗接种的认识:选择重组病毒载体或全病毒粒子灭活疫苗

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2021-01-25 DOI: 10.31069/japsr.v3i4.1

R. Mishra

引用次数: 1

Treatment with Corticosteroids may Link to Higher Risk of COVID-19 Disease? 使用皮质类固醇治疗可能会增加COVID-19疾病的风险?

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2021-01-01 DOI: 10.21477/IJAPSR.6.1.1

Q. Pirzada, Somia Gul, Faizan Baig

{"title":"Treatment with Corticosteroids may Link to Higher Risk of COVID-19 Disease?","authors":"Q. Pirzada, Somia Gul, Faizan Baig","doi":"10.21477/IJAPSR.6.1.1","DOIUrl":"https://doi.org/10.21477/IJAPSR.6.1.1","url":null,"abstract":"Corticosteroids are one of the important natural hormones released in the body that play a vital role in metabolism due to their intense anti-inflammatory, immunomodulatory and immune suppressive activity. These are most prescribed medications available in various dosage forms like topical formulations, inhalers and injectables. The current outbreak of corona virus disease COVID-19 became a global threat and primary concern worldwide. In respiratory patients, the use of non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids exacerbate the disease symptoms of COVID-19 patients, as they are often regarded as immunosuppressive drugs. Inhaled corticosteroids (ICS) are considered as first line treatment of asthma and chronic obstructive pulmonary disease (COPD). COVID-19 disease led the upper respiratory tract illness. ICS are used in the treatment of early symptoms of COVID-19 disease in low doses. Asthmatic patients or patients with chronic obstructive lung disease, who are on regular use of ICS were found to have a low risk of early symptoms of severely ill COVID-19 disease. Although there appeared to be some evidence that corticosteroid therapy may be beneficial in treatment of corona virus disease, but it is also reported to be applicable only at the early acute phase. The literature records revealed that injectable formulations of corticosteroids are known to suppress the immunity in patients infected with SARS-CoV2. The present review is to study the different formulations of corticosteroids and their possible use in COVID-19 progression.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80603890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Antifungal Finishing of Fabrics with Natural Dyes from Aerial Biomass of Perilla frutescens (L.) Britton 紫苏气生生物质天然染料对织物抗菌整理的研究布里顿

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2021-01-01 DOI: 10.21477/IJAPSR.6.1.2

A. Pál, Rakesh Kumar, Y. C. Tripathi

{"title":"Antifungal Finishing of Fabrics with Natural Dyes from Aerial Biomass of Perilla frutescens (L.) Britton","authors":"A. Pál, Rakesh Kumar, Y. C. Tripathi","doi":"10.21477/IJAPSR.6.1.2","DOIUrl":"https://doi.org/10.21477/IJAPSR.6.1.2","url":null,"abstract":"Increased environmental consciousness coupled with detrimental impacts of synthetic dyes and consumers’ concern over hygiene, cleanliness and protection, the demand for functional textiles has increased in recent years. Antimicrobial finishing imparts protective properties to textiles besides attractive shades. The study was aimed to determine the antifungal activity of colourants from aerial biomass of Perilla frutescens and dyed fabrics against pathogenic fungi infesting textiles materials. Antifungal activity of natural dye extracted from aerial biomass of Perilla frutescens against the selected pathogenic fungi viz., Aspergillus niger, Aspergillus flavus, Fusarium moniliforme, Fusarium solani, and Penicillium decumbens was evaluated by agar-well diffusion method. The MIC of the natural dye against each of the test fungi was determined by broth dilution method. Dyed silk, wool and cotton fabrics were also evaluated for antifungal activity by standard method. The natural dye showed antifungal activity against all the five test fungi in a concentration dependent manner. The treatment dose of 1000μg/ml recorded the highest growth reduction in all the test fungi, nearly at par with the positive control. The MICs of natural dye against the test fungi ranged from 32.39 to 36.50μg/ml. All kinds of dyed fabrics also showed remarkable antifungal efficacy against the test fungi. Dyed wool fabric exhibited the maximum growth reduction followed by silk and cotton. The result of the study demonstrated the remarkable antifungal activity of natural dye from Perilla frutescens aerial biomass and dyed fabrics. Therefore, Perilla frutescens can be considered as a potential source of natural dye with functional properties and can be used in protective finishing of different kinds of textile fabrics.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90211951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

TOPICAL APPLICATION OF TERMINALIA CHEBULA CREAM INHIBITS ULTRAVIOLET-B-INDUCED PSORIASIS IN RATS 局部应用桔黄乳膏抑制紫外线b诱导的大鼠银屑病

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2020-12-17 DOI: 10.31069/JAPSR.V3I3.4

Aruna Pai, J. Rao, Madhu J. Rajendra, Ashish Jain

{"title":"TOPICAL APPLICATION OF TERMINALIA CHEBULA CREAM INHIBITS ULTRAVIOLET-B-INDUCED PSORIASIS IN RATS","authors":"Aruna Pai, J. Rao, Madhu J. Rajendra, Ashish Jain","doi":"10.31069/JAPSR.V3I3.4","DOIUrl":"https://doi.org/10.31069/JAPSR.V3I3.4","url":null,"abstract":"Introduction: The present study aims at evaluating anti oxidant activity and inhibition of topical application of Terminalia chebula cream in ultraviolet –B-induced psoriasis in rats. Materials &Methods: The seeds of Terminalia chebula were dried and powder was extracted with chloroform, ethyl acetate, ethanol, methanol, and deionized water by cold maceration method. Total phenolic content, total tannin content and total triterpenoid content was determined by different methods. Anti oxidant activity was evaluated by DPPH method and reducing power assay. Cream formulation of the optimized extract was prepared by hot fusion method. Psoriasis was induced by irradiatiating for 30 min at a vertical distance of 20 cm with UV light (385 nm) on the skin. Severity index, hydroxyproline content and epidermal thickness was determined. Results and Discussion: Total Phenol (mg gallic acid/ g) content, Total Tannins (mg catechin/ g) content and Total triterpenoid (mg ursolic acid/ g) content was found to be significant for water extract.The reducing ability of water extract was always higher than methanol extract at all the concentrations. Conclusion: We concluded that cream containing 0.1% water extract of Terminalia chebula seeds possess antioxidant activity along with potent antipsoriatic activity. Further, application of Terminalia chebula cream resulted in decrease in relative epidermal thickness of animal skin as well as other histopathological features. The present investigation aims at the development of potent phytomedicine for treatment of psoriasis from the Terminalia chebula plant.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89861743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ROLE OF KYNURENINE PATHWAY METABOLITES IN DEPRESSION-A REVIEW 犬尿氨酸途径代谢物在抑郁症中的作用综述

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2020-12-17 DOI: 10.31069/JAPSR.V3I3.1

P. Soni, Lubhan Singh, Prabhat K. Singh, Sokindra Kumar

{"title":"ROLE OF KYNURENINE PATHWAY METABOLITES IN DEPRESSION-A REVIEW","authors":"P. Soni, Lubhan Singh, Prabhat K. Singh, Sokindra Kumar","doi":"10.31069/JAPSR.V3I3.1","DOIUrl":"https://doi.org/10.31069/JAPSR.V3I3.1","url":null,"abstract":"Today most common psychiatric problem across the world is depression and stress is main source of ailment. According to World health organization, it will be the main cause of morbidity by 2020 in the world. Depression can critically affects the quality of life as it is characterized by many symptoms like unhappy feeling, lack of interest and pleasure, down energy, inadequacy, regret feeling, slow-down of thoughts or reduction in physical movement, speech can affects, altered appetite or sleep, sad, and increase the risk of suicide. Human body is inadequate to produce tryptophan which is a crucial amino acid; therefore it must be required from diet. After absorption, L-tryptophan crosses the BBB (Blood brain barrier) by non-specific L-type amino acid transporter and act as precursor to various metabolic pathways in central nervous system (CNS). Kynurenine is an important pathway that is associated with tryptophan (TRP) metabolism, where it develops a lot of metabolites such as 3-hydroxykynurenine (3HK), anthranilic acid (AA), kynurenic acid (KYNA), 3-hydroxyanthranilic acid (3HAA) and quinolinic acid (QUIN) known as kynurenines. It is already reported previously that disturbance in neuroprotective and neurotoxic metabolites leads to many psychiatric disorders. This review summarizes the role of kynurenine pathway metabolites in depression. \u0000 ","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89218516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CORONA VIRUS OUTBREAK AND IT’S IMPACT ON THE GLOBAL PHARMACEUTICAL INDUSTRIES 冠状病毒爆发及其对全球制药业的影响

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2020-12-17 DOI: 10.31069/JAPSR.V3I3.3

Vikas Sharma, C. Majee, R. Kaushik, D. Sharma, Sunita Kumari, Rajni Sawanny, Sharat Chandra Bhardwaj, Baitullah Abdali

{"title":"CORONA VIRUS OUTBREAK AND IT’S IMPACT ON THE GLOBAL PHARMACEUTICAL INDUSTRIES","authors":"Vikas Sharma, C. Majee, R. Kaushik, D. Sharma, Sunita Kumari, Rajni Sawanny, Sharat Chandra Bhardwaj, Baitullah Abdali","doi":"10.31069/JAPSR.V3I3.3","DOIUrl":"https://doi.org/10.31069/JAPSR.V3I3.3","url":null,"abstract":"There is another general wellbeing emergencies undermining the world with the rise and spread of 2019 novel coronavirus (2019-nCoV) or the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The infection started in bats and was transmitted to people through yet obscure go-between creatures in Wuhan, Hubei territory, China in December 2019. There are more than 48,15,484 infected cases all around the globe. This can be transmitted from one to another very quickly only by coughing or sneezing or direct contact with infected person. World Health Organization also has stated that there is no future course of this virus is available till now. As a preventive measure the complete stop on outgoings i.e. lockdown is surrendered. The lockdown all over the country or all around the globe is becoming a huge crisis for the economy and of countries the life cycle of the humans. The lockdown has affected all the businesses, works, private sectors as well as government sectors. The impact of lockdown on the pharmaceutical industries can be a great boon if its taken positively. \u0000Keywords: coronavirus, SARS-CoV 2, wuhan, transmitted, crisis, lockdown, impact.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73408150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

LIPOSOMAL DRUG DELIVERY SYSTEM – A REVIEW 脂质体给药系统研究进展

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2020-12-17 DOI: 10.31069/JAPSR.V3I3.2

A. Srivastava, Amresh Gupta, Arpita Singh

引用次数: 1

SettingsTOPICAL APPLICATION OF TERMINALIA CHEBULA CREAM INHIBITS ULTRAVIOLET-B-INDUCED PSORIASIS IN RATS 目的:临床应用桔梗乳膏抑制紫外线b诱导的大鼠银屑病

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2020-12-01 DOI: 10.31069/10.31069/japsr.v3i3.4

Aruna Pai, J. Rao, Madhu J. Rajendra, Ashish Jain

{"title":"SettingsTOPICAL APPLICATION OF TERMINALIA CHEBULA CREAM INHIBITS ULTRAVIOLET-B-INDUCED PSORIASIS IN RATS","authors":"Aruna Pai, J. Rao, Madhu J. Rajendra, Ashish Jain","doi":"10.31069/10.31069/japsr.v3i3.4","DOIUrl":"https://doi.org/10.31069/10.31069/japsr.v3i3.4","url":null,"abstract":"Introduction: The present study aims at evaluating anti oxidant activity and inhibition of topical application of Terminalia chebula cream inultraviolet –B-induced psoriasis in rats.Materials and Methods: The seeds of Terminalia chebula were dried and powder was extracted with chloroform, ethyl acetate, ethanol,methanol, and deionized water by cold maceration method. Total phenolic content, total tannin content and total triterpenoid content wasdetermined by different methods. Anti oxidant activity was evaluated by DPPH method and reducing power assay. Cream formulation of theoptimized extract was prepared by hot fusion method. Psoriasis was induced by irradiatiating for 30 min at a vertical distance of 20 cm withUV light (385 nm) on the skin. Severity index, hydroxyproline content and epidermal thickness was determined.Results: Total Phenol (mg gallic acid/ g) content, Total Tannins (mg catechin/ g) content and Total triterpenoid (mg ursolic acid/ g) contentwas found to be significant for water extract.The reducing ability of water extract was always higher than methanol extract at all theconcentrations.Conclusion: We concluded that cream containing 0.1% water extract of Terminalia chebula seeds possess antioxidant activity along withpotent antipsoriatic activity. Further, the application of Terminalia chebula cream resulted in decrease in relative epidermal thickness of animalskin as well as other histopathological features. The present investigation aims at the development of potent phytomedicine for treatment ofpsoriasis from the Terminalia chebula plant.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77509694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1