{"title":"PATIENT COUNSELING: A COMPLETE GUIDE FOR COMPLIANCE","authors":"Abdul Kader Mohiuddin","doi":"10.31069/JAPSR.V1I4.1","DOIUrl":"https://doi.org/10.31069/JAPSR.V1I4.1","url":null,"abstract":"While drugs have the capacity to enhance health, they all have the potential to harm if prescribed inappropriately. For this reason, it is recommended that healthcare professionals who prescribe medications should exercise counseling, as general people have least idea and interest about healthcare settings, use of medicine and their untoward effects. Pharmacists have crucial role plays in both handling prescription and prescribing. A rational prescribing is the sole of patient safety, compliance and patient relief. Patients have an altered mental state mostly driven by emotional disturbance for being ill. Along with that cultural and economic factor gives rise to a question of out of the pocket expense. The sole of this article is to impart necessity of a professional’s assistance that help patient to understand his illness, benefit of treatment and a clear instruction to follow. Other than patients in this materialistic world, all are busy. Mostly prescribers avoid patient counseling and patients have their medication without maintaining proper guidelines. This article should impart an expression of reminder to all providers to be more patient to give more to their patients. Conversely general people should be careful about demanding full assistance of clear instruction for any drug or non-drug treatment procedure. The soul of this article was to detail about patient compliance and therapeutic drug outcomes after a comprehensive patient counseling. Along with students, researchers and professionals of different background and disciplines, e.g. Pharmacists, doctors, nurses, hospital authorities, public representatives, policy makers and regulatory authorities have to acquire much from this article.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83946729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. K. Chaudhari, D. Pathak, Z. Hussain, Prevesh Kumar, V. Yadav
{"title":"IMPORTANCE OF HERBAL DRUG FOR NEW DRUG DEVELOPMENT","authors":"V. K. Chaudhari, D. Pathak, Z. Hussain, Prevesh Kumar, V. Yadav","doi":"10.31069/JAPSR.V1I4.3","DOIUrl":"https://doi.org/10.31069/JAPSR.V1I4.3","url":null,"abstract":"Drug discovery leading to robust and viable lead candidates’ remains a challenging scientific task, which is the transition from a screening hit to a drug candidate, requires expertise and experience. Natural products and their derivatives have been recognized for many years as a source of therapeutic agents and of structural diversity. However, in addition to their chemical structure diversity and their biodiversity, the development of new technologies has revolutionized the screening of natural products in discovering new drugs.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":"25 6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91238042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF GUAZUMA ULMIFOLIA","authors":"Bhawna Damor, K. Gaur, A. Dashora, S. A. Parra","doi":"10.31069/JAPSR.V1I4.4","DOIUrl":"https://doi.org/10.31069/JAPSR.V1I4.4","url":null,"abstract":"\u0000 \u0000 \u0000 \u0000Introduction: Guazuma ulmifolia (Sterculiaceae) is commonly used in folk medicine as a single drug remedy to treat various ailments like; skin diseases, headache, wounds, ulcers, asthma, kidney disease and malaria. However, the use of the herb for treatment of pain and inflammation has not been scientifically investigated. Objective: This study of 80% methanolic crude extract of the leaves of Guazuma ulmifolia was evaluated for its analgesic and anti-inflammatory properties using established animal models. Material and methods: Wister albino rats were randomly divided into four groups of six rats per group. The control group was orally given 2 ml/kg (p.o.) of distilled water. The positive control received standard drug (Diclofenac 10 mg//kg, Indomethacin 20 mg/kg). The rest of the groups were treated with 80% methanolic extract of Guazuma ulmifolia at doses of 250 and 500 mg/kg. Animals were then subjected to tests using hot plate and tail-clip for analgesic activity, for anti-inflammatory activity carrageenan-induced paw edema test and histamine-induced paw edema test was used. Result and Discussion: Guazuma ulmifolia extract showed a dose-dependent significant reduction of pain in analgesia models (p<0.001) with 500 mg/kg dose producing the highest reduction. The extract significantly reduced carrageenan-induced inflammation in a dose-independent manner, in which the highest reduction of inflammation was observed at 500 mg/kg. Conclusion: The data collectively indicate that 80% methanolic extract of Guazuma ulmifolia leaves has potential analgesic and anti-inflammatory activities. \u0000 \u0000 \u0000 \u0000 \u0000","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89766829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mixed Mullerian Tumor Primitive of Peritoneum: Report of a Case","authors":"S. Erra, S. L. Mastro, E. Nano","doi":"10.21477/IJAPSR.4.1.1","DOIUrl":"https://doi.org/10.21477/IJAPSR.4.1.1","url":null,"abstract":"Carcinosarcoma is a rare and aggressive cancer that usually affects women in post menopausae; it represents 3% of all uterine neoplasms. Carcinosarcoma is a biphasic tumor characterized by a double component: a carcinomatous and a sarcomatous one, in variable amount of percentage from case to case. In the present article, a very rare case of primitive peritoneal carcinosarcoma is described in an 86-year-old woman, with senile atrophy of the uterus.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86279482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. H. Coulibaly, Y. S. Brou, Sagne Jacques Akpa, J. Creus, A. Trokourey
{"title":"Corrosion Inhibition of Copper in 2M Nitric Acid Solution by 2-(Thiobenzyl)-5-Nitro-1H-Benzimidazole","authors":"N. H. Coulibaly, Y. S. Brou, Sagne Jacques Akpa, J. Creus, A. Trokourey","doi":"10.21477/IJAPSR.3.4.2","DOIUrl":"https://doi.org/10.21477/IJAPSR.3.4.2","url":null,"abstract":"Pickling with nitric acid is commonly practiced in industry for finishing metal surfaces. The use of inhibitors during the pickling operation is of very recent origin. The TBNBI inhibition effect on copper corrosion in 2M nitric acid solution was investigated by weight loss method in relation to the temperature (25 to 40°C) and inhibitor concentration range 10-4 to 5.10-3 M. The results show that TBNBI is a good inhibitor for copper and the inhibition efficiency increases with concentration of TBNBI but decreases with increase in temperature. The adsorption parameters (ΔGa0ds ,ΔHa0ds ,ΔSa0ds ) and the activation ones * * a a a (E ,ΔH ,ΔS ) for the corrosion process in inhibited and uninhibited nitric acid solution were also calculated using Arrhenius equations. It can be concluded that the adsorption of the compound is spontaneous and found to occur through both physisorption and chemisorption processes. The adsorbed film on copper surface was characterized using optic microscopy and Raman spectroscopy. The surface analysis confirmed the inhibition action of TBNBI. Quantum chemical calculations using Gaussian 09 at B3LYP level with 6-31G (d,p) basis set lead to obtain molecular descriptors such as EHOMO (energy of the highest occupied molecular orbital), ELUMO (energy of the lowest unoccupied molecular orbital), ΔE (energy gap) and μ (dipole moment). The global reactivity descriptors such as χ (electronegativity), η (hardness), S (softness) and ω (electrophilicity index) were derived using Koopman’s theorem and analyzed. We used the condensed Fukui function and softness indices, Mulliken population analysis for local reactivity study. The calculated results are consistent with the experimental data.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":"303 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77933304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Y. S. Diki, Gbè Gondo Didier Diomandé, Sagne Jacques Akpa, Augustin Ouedraogo, Lemeyonouin Aliou Guillaume Pohan, P. Niamien, A. Trokourey
{"title":"Aluminum Corrosion Inhibition by 7-(Ethylthiobenzimidazolyl) Theophylline in 1M Hydrochloric Acid: Experimental and DFT Studies","authors":"N. Y. S. Diki, Gbè Gondo Didier Diomandé, Sagne Jacques Akpa, Augustin Ouedraogo, Lemeyonouin Aliou Guillaume Pohan, P. Niamien, A. Trokourey","doi":"10.21477/IJAPSR.3.4.1","DOIUrl":"https://doi.org/10.21477/IJAPSR.3.4.1","url":null,"abstract":"Inhibitive properties of 7-(ethylthiobenzimidazolyl) theophylline (7-ETBT) molecule for the corrosion of aluminum (Al) in one molar hydrochloric acid medium have been investigated using mass loss and Tafel polarization methods. The results suggest spontaneous and predominant physical adsorption of 7-ETBT on the metal surface which obeys Langmuir isotherm model. The studied inhibitor showed excellent inhibition efficiency up to 94.07 % at 298 K for its optimum concentration (2 mM). Moreover, Tafel polarization method revealed that 7-ETBT is a cathodic-type inhibitor. Further investigation on the morphology using scanning electron microscopy (SEM) has confirmed the existence of a protective film of inhibitor molecules on aluminum surface. Theoretical approach for the performance of 7-ETBT as Al corrosion inhibitor is also done using Density Functional Theory (DFT) level with B3LYP exchange correlation functional for 6-31G (d, p) basis set. The results provided by this theoretical study are consistent with the experimental data. All the results have shown an evidence of the effectiveness of the inhibitive effect of 7-ETBT on Al.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87997080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Rare Case of Male Breast Metastasis from Previously Removed Renal Cell Carcinoma","authors":"S. Erra, S. L. Mastro, S. Modena","doi":"10.21477/IJAPSR.3.4.3","DOIUrl":"https://doi.org/10.21477/IJAPSR.3.4.3","url":null,"abstract":"Renal cell carcinoma (RCC) is the most lethal pathology affecting the urinary system, especially in people over 65 years and with an incidence of about 2% per year. RCC can be classified according to histological findings, cytogenetic abnormalities, biological features and response to therapy. This article reports an extremely rare case of clear cell RCC in a 73 years old male patient with metastasis in the breast and in the bronchi, presented 15 years after surgical resection of primitive renal tumor.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72737439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Overview of Different Waste Treatment Methods","authors":"N. Khan, N. Jameel, M. Khan","doi":"10.21477/IJAPSR.3.3.2","DOIUrl":"https://doi.org/10.21477/IJAPSR.3.3.2","url":null,"abstract":"Wastes including chlorinated aliphatic hydrocarbons, refractory organic compounds, aromatic derivatives, radionuclides etc., poses a serious threat to the environment. Therefore numerous in situ /ex situ treatment method are formulated to remove or immobilize such contaminates occurring in soil, water or air to minimize its harmful effects.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":"IA-13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84592600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Amulya, N. N. Kumar, C. Mounika, V. Kowmudi, N. Supriya, K. Madhuri
{"title":"Development and Validation of RP-HPLC Method for the Simultaneous Estimation of Haloperidol and Trihexyphenidyl in API and Combined Tablet Dosage Form","authors":"E. Amulya, N. N. Kumar, C. Mounika, V. Kowmudi, N. Supriya, K. Madhuri","doi":"10.21477/IJAPSR.3.3.3","DOIUrl":"https://doi.org/10.21477/IJAPSR.3.3.3","url":null,"abstract":"A rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validated of Trihexyphenidyl and Haloperidol, in its pure form as well as in tablet dosage form. Chromatography was carried out on a Altima C18 (4.6 x 150mm, 5μm) column using a mixture of Methanol: TEA Buffer pH 4.5: Acetonitrile (50:25:25) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 225 nm. The retention time of the Trihexyphenidyl and Haloperidol was 2.102, 3.537±0.02min respectively. The method produce linear responses in the concentration range of 15-75ppm of Trihexyphenidyland 37.5-187.5ppm of Haloperidol. The method precision for the determination of assay was below 2.0%RSD. The method is useful in the quality control of pharmaceutical formulations.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83366025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Sagadevan, R. Ramya, S. Rathishkumar, S. Vijayakumar, L. Surendran, P. Janarthanan, C. Sajith
{"title":"Overview on Common Respiratory Virus","authors":"P. Sagadevan, R. Ramya, S. Rathishkumar, S. Vijayakumar, L. Surendran, P. Janarthanan, C. Sajith","doi":"10.21477/ijapsr.3.3.1","DOIUrl":"https://doi.org/10.21477/ijapsr.3.3.1","url":null,"abstract":"Respiratory viruses have been recognised as causative agents for a wide spectrum of clinical manifestations and severe respiratory compromise in neonates during birth hospitalisation. Early-life respiratory virus infections have also been shown to be associated with adverse long-term consequences. Preventing virus infections by intensifying hygiene measures and cohorting infected infants should be a major goal for neonatal intensive care units, as well as more common use of virus diagnostics.","PeriodicalId":13749,"journal":{"name":"INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72714729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}